Drug Discovery Research
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Mechanisms of Cancer Resistance Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.
CORE JOB FUNCTION(S):
• LAB BASED role. Using current/new techniques to address questions of drug mechanism of action, drug combinations and sensitivity/resistance. Develop and qualify new PD marker assays
• Set up and utilize a wide range of in vitro oncology models
• Design and execute experiments to characterize small molecule inhibitors
• Interact with project teams and contract laboratories for design and oversight of molecular, cellular and/or in vivo studies
• May be responsible for co-authoring non-clinical pharmacology study reports and scientific publications
• Expected to understand departmental goals and development processes
• Execute experiments independently, troubleshoot as needed
• Interpret and discuss data
• Familiar/keeps current with literature
• Communicate via email, meetings and reports
• Responsible for the completion of assignments that have an impact on functional goals
• At least 5 years of post-college research experience in the field of molecular/cell biology, physiology, toxicology, translational development or pharmacology or another relevant field.
• Industry experience in drug discovery or translational research in the pharma or biotech setting is a plus
• Ability to conduct experimental work independently, with accurate, detailed record-keeping.
• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work
• Ability to summarize and interpret scientific data in a clear, concise and accurate manner
• Extensive experience performing laboratory work, including handling cell cultures and performing analysis of protein and DNA/RNA samples using a variety of methodologies.
• Experienced in the design and development of cell based assays using various technology platforms.
• Experience in oncogenic signaling pathways is a plus.
• Experience in one or more of the following techniques is expected: Flow cytometry, western blotting, cell culture, cell cycle and apoptosis assays in single or multiplexing formats, qPCR/RT-PCR.
• Excellent oral and written communication skills
• Strong problem-solving skills
• Able to be flexible in case of changing priorities
• Should have solid understanding of relevant scientific principles
• Able to identify scientific and technical problems and potential solutions
• Able to work independently and as a part of a team
• Able to provide input into experimental designs
• Able to interpret data/questions independently and articulate recommendations for resolution with strong scientific rationale
• Able to recognize risks and develop contingency plan.
• Able to communicate with peers and supervisors
• Able to begin to contribute to the achievement of workgroup/team goals
• Key contributor to collaborative efforts
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.