Job Details

Director, Biochemistry & Cellular Pharmacology, Leads Discovery and Optimization, Redwood City, CA

Drug Discovery Research

icon-location-marker Redwood City - CA - US
Posted 47 days ago Full_time R1548024

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Director, Biochemistry & Cellular Pharmacology, Leads Discovery and Optimization, Redwood City, CA

Description:

The Leads Discovery & Optimization (LDO) is a dynamic organization that supports the entire continuum of drug discovery (from lead identification to clinical candidate delivery) at Bristol Myers Squibb. The organization leverages state of the art technologies, complemented by deep subject matter expertise and broad scientific knowledge, to deliver innovative and comprehensive preclinical in vitro datasets to support our drug discovery pipeline in disease areas such as cell therapy, oncology, immunology, fibrosis and cardiovascular diseases.

The LDO Redwood City team is seeking an exceptional scientific leader to join our team as Director, and Head of Biochemistry & Cellular Pharmacology group. This qualified individual will have demonstrated track record of success in managing scientists leading biochemistry and cellular pharmacology activities to support drug discovery programs from lead discovery through IND-enabling studies. This leader will mentor and train scientists in different biochemical and cellular assay formats to interrogate target biology, function and pharmacology with a translational line of sight. This individual will also play a leadership role representing LDO function on key strategic governance committees focused on programs within Tumor Microenvironment TRC.

As a Director within LDO, this qualified individual will assume the leadership role for our Biochemistry and Cellular Pharmacology group and set the strategic direction for this critical function. This individual will work with his/her team to propose in vitro assay paradigm for enabling lead discovery, mechanistic studies, and molecular profiling to drive chemistry design and optimization.  This Director will manage the work of a dynamic and multidisciplinary group of scientists developing and implementing medium to high throughput cell-based assays (2D/3D cultures) using cutting edge and innovative technologies. This individual will play a critical role in for progressing a portfolio of programs in support of the Cambridge site drug discovery mission. 

Duties/Responsibilities:

  • Lead and mentor a team of scientists performing in vitro pharmacology studies with the goal of identifying novel drug candidates for supporting BMS RWC site programs
  • Design, develop and direct the execution of physiologically relevant biochemical, biophysical and cell based assays critical to the discovery and evaluation of compound activity and mechanism of action studies
  • Collaborate with key functional stakeholders in Biology, Chemistry, Translational pharmacology, DMPK to bridge LDO activities to critical path decision driving experiments
  • Represent LDO function on site governance and present results and strategic vision to Biology and Chemistry leadership

Qualifications:

  • PhD with 10+ years of relevant industry experience in early drug discovery setting
  • Demonstrated track record of success in small molecule drug discovery and leadership/managerial capabilities in matrix environment
  • Experienced leader with established track record of managing senior level PhD scientists
  • Passionate about leveraging in vitro biochemical and cell-based systems in driving molecular discovery and optimization and bridging in in vitro datasets to in vivo PD/efficacy readouts
  • A commitment to the highest quality research and ability to manage a diverse portfolio of programs with competing priorities
  • Hands-on experience in cell-based assay development and execution, across different cellular assay formats (HTRF, BRET, luminescence, ALPHA technology, ELISA, western, etc.) and nucleic acid-based (RT-qPCR)), with a strong background in de novo assay design, quality control, and high-throughput processes
  • Hands-on experience in developing biochemical assays (enzymatic turnover, protein-protein interactions, radioligand binding, probe displacement, etc.)  across multiple protein classes
  • Strong written and verbal communication skills and demonstrated strength in a matrix organization
  • Established track record of successful multitasking and rapid execution across a portfolio of drug discovery programs with competing priorities

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation.  Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment.  This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

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