Drug Discovery Research
The Associate Research Scientist will join the Oncology Resistance Biology group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology. The position will utilize cellular biological and immunological techniques to screen and validate targets that confer resistance to immunotherapies.
The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling studies. The candidate will be expected to effectively collaborate with colleagues in the oncology, immunology, immuno-oncology, protein engineering/antibody development and medicinal chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.
- A B.S. with a minimum of 4 years of experience, or an M.S. with a minimum of 2 years of academic/industrial experience with strong scientific knowledge and research experience in cellular biology and/or immunology is required.
- Demonstrated independence in experimental design, execution, data analysis and troubleshooting are required.
- A strong background in Immuno-oncology or immunology is required.
- Hands-on experience with immune cell isolation/propagation and in vitro and ex vivo immune cell-based functional assays or co-culture assays using primary human/murine PBMCs or BMMCs and cancer cells.
- Hands on experience with a wide range of cellular biology and immunology assays, including immune and cancer cell culture, multi-color flow cytometry, western blotting, ELISA, siRNA/shRNA knockdown, CRISPR-mediated genome editing, qPCR, cell proliferation assays, cloning, lentivirus generation and transduction is desired.
- Experience with functional genetic and/or small molecule screens and next generation sequencing library preparation is desired.
- Experience with in vivo/ex vivo pharmacology, including rodent handling and common procedures including tissue processing is desired.
- Proficiency in utilizing software such as Graph Pad, Flowjo, Microsoft office etc. for data analysis and figure generation is highly desired.
- Experience in cancer genome data mining through use of desktop tools/interfaces and public databases (e.g., CBIO, TCGA, CCLE, Genepattern etc) is highly desirable.
- Ability to mentor more junior scientists and colleagues on best practices in the laboratory would be highly valued.
- Attention to detail with excellent organizational and record keeping skills is a requirement.
- Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.
- This position is located in Cambridge, MA. There will be less than 10% travel.