Drug Discovery Research
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.
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The Leads Discovery & Optimization (LDO) group is seeking a Research Investigator to support the LDO Kinome Hits-to-Leads platform. The candidate will have responsibility for developing, validating, and executing mechanistic assays and cellular assays to support the high-throughput screening (HTS) and Lead Optimization kinome platform. The candidate will have the responsibility to characterize kinase targets, their inhibitors as well as perform profiling and selectivity assays. The candidate will be responsible for the development and validation of robust, reproducible plate based biochemical and cellular assays including kinetic and mechanistic studies to characterize kinase targets, biochemical pathways, and mechanism of action of lead compounds. The person will be expected to operate standard high throughput liquid handling instruments as well as plate readers. The person will be able to readily adapt bench level assay protocols to full automation by designing and articulating automated assay flow charts. The successful candidate will be expected to work with minimal supervision and have responsibility to research relevant literature to guide assay design, day to day experimentation, analysis and interpretation of data, and be able to effectively organize and present data in project working groups.
Develop and execute kinetic and mechanistic enzyme assays to understand kinase targets, their function and regulation, along with determining mechanism and binding location of inhibitors, and protein/ligand SAR
Design, execute and analyze robust, automated cellular and biochemical assays for support of the LDO Kinome hits-to-leads-platform
Participate on multi-disciplinary teams, including oral presentations of results, and contribution to the understanding of biochemical pathway and mechanism of action of kinase targets
Hands-on design, execution, and troubleshooting of assays to support small molecule drug discovery projects
Collaborate closely with assay scientists to devise optimal strategies for assay development
Ability to manage multiple projects simultaneously and be a strong advisor to team members
Identify, evaluate, and implement new technologies and processes to improve assay quality and efficiency
Review and relevant literature and leverage knowledge to solve problems in a timely fashion
Ph.D. with postdoctoral experience and 3-5 years of small molecule drug discovery experience in an industry setting.
Extensive experience in cellualar and biochemical assay design for enzyme target classes, including mechanism of action and kinetic assay development
Experience in assay design across a broad array of high throughput bioassay techniques including fluorescence, Homogenous Time Resolved Fluorescence, and luminescence
Working knowledge of various approaches for assay automation including workstations and fully automated systems
Experience in miniaturizing assays for a range of modalities
Skilled use of the central IT platforms for data handling, image analysis, data reduction and data reporting
Experience with MS Office, MS SharePoint, Spotfire, MS Project and Mosaic software
An independent, flexible and high-energy scientist
High attention to detail, strong written and verbal communication skills and ability to effectively collaborate across groups at all stages of projects
Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.