Inflammation Gene Signatures

What are inflammation gene signatures? Tumor inflammation gene signatures are gene expression profiles reflective of the presence or absence of immune cells in the tumor microenvironment.^1,2

How are inflammation gene signatures evaluated? Inflammation gene signatures can be measured via targeted mRNA expression profiling and/or RNA-sequencing.^3,4

Why are inflammation gene signatures important? Inflammation gene signatures have been defined for different tumor types.^2-4 Inflammation gene signatures are under investigation as potential biomarkers of response to I-O therapy.⁵

References
1. Galon J et al. Immunity. 2013; 39: 11-26.
2. Linsley PS et al. PLoS One. 2015. Doi: 10.1371/journal.pone.0138726.
3. Hugo W et al. Cell. 2016; 165:35-44.
4. Cesano A. J Immunother Cancer. 2015; 3:42.
5. Gibey GT et al. Lancet Oncol. 2016; 16:e542-e551.