Inflammation Gene Signatures

Inflammation Gene Signatures

What are inflammation gene signatures? Tumor inflammation gene signatures are gene expression profiles reflective of the presence or absence of immune cells in the tumor microenvironment.1,2

How are inflammation gene signatures evaluated? Inflammation gene signatures can be measured via targeted mRNA expression profiling and/or RNA-sequencing.3,4

Why are inflammation gene signatures important? Inflammation gene signatures have been defined for different tumor types.2-4 Inflammation gene signatures are under investigation as potential biomarkers of response to I-O therapy.5

References
1. Galon J et al. Immunity. 2013; 39: 11-26.
2. Linsley PS et al. PLoS One. 2015. Doi: 10.1371/journal.pone.0138726.
3. Hugo W et al. Cell. 2016; 165:35-44.
4. Cesano A. J Immunother Cancer. 2015; 3:42.
5. Gibey GT et al. Lancet Oncol. 2016; 16:e542-e551.