What is TMB? Tumor mutational burden is a measurement of mutations carried by tumor cells and is a predictive biomarker being studied to evaluate its association with response to Immuno-Oncology (I-O) therapy.1, 2
How is TMB measured? DNA sequencing, such as Whole Exome Sequencing (WES) is typically used to determine the number of acquired mutations in the tumor.1, 2
Why is TMB important?
Tumor cells with high TMB may have more neoantigens, with an associated increase in cancer-fighting T cells in the tumor microenvironment and periphery. These neoantigens can be recognized by T cells, inciting an anti-tumor response.