Tregs

Tregs

Regulatory T cells (Tregs) or suppressor cellsĀ , suppress the immune response by modulating the activation of effector T cells.1 Tregs are important in maintaining self-tolerance and preventing autoimmunity.1,2 The increased infiltration of Tregs into the tumor microenvironment has been observed in a variety of tumor types.3 The presence and activity of Tregs in tumor tissue and blood can be evaluated by cell-sorting technology such as flow cytometry.4

References
1. Pardoll DM. Nat Rev Cancer. 2012;12(4):252-264.
2. Melero I et al. Nat Rev Cancer. 2015;15(8):457-472.
3. Nishikawa H et al. Curr Opin Immunol. 2014;27:1-7.
4. Santegoets SJ et al. Cancer Immunol Immunother. 2015;64(10):1271-1286.