MDSCs

MDSCs

Myeloid-derived suppressor cells (MDSCs) are recruited to the tumor microenvironment to suppress effector cell responses through mechanisms including the promotion of T cell exhaustion and dysfunction.1,2 Increased presence of MDSCs in the tumor microenvironment has been observed in a variety of solid tumors.2 The presence of MDSCs in tumor tissue and blood can be evaluated by cell-sorting technology such as flow cytometry.3

References
1. Joyce JA, Pollard JW. Nat Rev Cancer. 2009;9(4):239-252.
2. Kumar V et al. Trends Immunol. 2016;37(3):208-220.
3. Vasquez-Dunddel D et al. J Clin Invest. 2013;123(4):1580-1589.