Senior Research Investigator I, NGS

Drug Discovery Research

icon-location-marker Cambridge - MA - US
Posted 21 days ago Full_time R1518244

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

 

Join us and make a difference.  We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Senior Research Investigator I

Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together.  Driven to make a difference, from innovative research to hands-on community support.  Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

We seek a highly motivated, detail-oriented leader with broad experience in application of single cell genomics tools in solving complex biological problems. Experience implementing or optimizing methods for single cell RNA-seq, single cell DNA -seq or CITE-seq approaches preferred. The successful candidate will have broad experience in Next Generation Sequencing (NGS) work flows and associated analysis methods. Proficiency in various genomics methods and workflows is essential.

The individual will be part of the Genomics group at our Cambridge site, working as part of an integrated team dedicated to understanding mechanisms of immune resistance in cancer. Primary responsibilities include various single cell genomics-based assay development and implementation in support of drug discovery programs, novel genomic method development and optimization, establishing outreach and collaboration across the Cambridge area, leveraging its vibrant genomics ecosystem.

Responsibilities

Design and implementation of genomic assays in support of various research programs.

Play key role in optimizing existing NGS methods or developing new NGS protocols to suit needs.

Co-ordinate with investigators to execute genomics project data and analysis in a timely manner.

Manage NGS instrument operation and Maintenance.

Manage Research scientists to deliver genomic data to investigators

Coordinate NGS data analysis perform data interpretation

Manage outreach and collaborations with Cambridge genomics community

Maintain lab notebooks, compiles data, and details written experimental instructions, particularly in areas involving new technology and/or novel experimental approaches.

Requirements

The successful candidate will have Ph.D. in Molecular/Cell Biology or Genetics or Biochemistry with at least 2 years or M.S in Molecular/Cell Biology or Genetics with at least 5 years of relevant scientific lab experience with emphasis on applied genomics.

Broad hands-on experience in molecular Biology methods relevant to genomics

Experience applying genomic methods in Disease biology questions

Experience in NGS library generation and associated methods.

Experience in advanced Cell and Molecular Biology technique is essential.

Familiarity with NGS data analysis and data interpretation

Experience in working with FFPE and other clinical sample handling preferred.

Expertise in Cell separation technologies such as FACS/Microfluidics is a plus but not essential.

Ability to communicate effectively and manage projects

Extensive people and project/matrix team experience, with demonstrated ability to work effectively within multidisciplinary teams.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.