Drug Discovery Research
The Research Scientist will join the Integrated Oncology Discovery Research team at Bristol-Myers Squibb in Redwood City, CA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology. The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in the oncology, immunology, immuno-oncology, protein engineering/antibody development and medicinal chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.
- A B.S. degree with a minimum of 8 years or a M.S. degree with a minimum of 6 years of industrial experience with strong scientific knowledge and research experience in cancer biology/cellular and molecular biology as well as experience in immune-oncology.
- Demonstrated independence in experimental design, execution, data analysis and troubleshooting.
- Knowledge of small molecule pre-clinical drug development including knowledge of designing assays and flowcharts to identify and optimize drug candidates.
- Hands on experience with a wide range of in-vitro cellular and biochemical assays, including cell culture, western blotting, immunoprecipitation, ELISAs (MSD), reporter assays, siRNA/shRNA knockdown, CRISPR-mediated genome editing, qPCR, cloning, lentivirus generation and transduction
- Experience with in vivo/ex vivo pharmacology, including working knowledge of in-vivo PK, PD and efficacy studies.
- Experience in data mining through use of desktop tools/interfaces and public databases (e.g., UCSC genome Browser, CBIO, GTex, Oncoland etc).
- Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation.
- Ability to mentor more junior scientists and colleagues on best practices in the laboratory.
- Attention to detail with excellent organizational and record keeping skills.
- Excellent interpersonal skills with ability to interact effectively with people, internally and externally.
- This position is located in Redwood City, CA. There will be less than 10% travel.