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Protein homeostasis: A balancing act
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November 11, 2020      Updated: September 15, 2025

How does protein balance affect disease?

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Balancing the level of water in a bathtub is paramount — add too much and it spills over the side, too little, and there’s not enough to keep you warm.

Similarly, the human body must ensure it has the perfect amount of proteins at any given time to function normally through an equalizing process known as protein homeostasis.

Maintaining this balance of proteins is important because both overfilling, or protein accumulation, and underfilling, or protein deficiency, may lead to many diseases, including cancer and neurodegenerative disorders.

Bristol Myers Squibb is using this knowledge to advance innovative science and bring transformational therapies to patients.