Purpose/ Objectives of the jobs

The Sr. Mgr., BI&A Analytics / Market Research is responsible for using a combination of analytics tools and market research techniques to holistically answer key business questions in Japan.

In collaboration with the BI&A Lead and peer counterparts, this person develops and executes the integrated insights plan including qualitative / quantitative Market Research as well as data analytics projects (e.g. decision science, forecasting, resource allocation).

Key Responsibilities and Major Duties

• Designs and implements analytics, performance management reporting, and forecasting for planned and ad-hoc needs for Japan brands
• Designs and implements primary Market Research engagements to deliver and help embed customer insights into decision-making for brands
• Builds relationships and effectively influences all senior management stakeholders (GM, BUDs, Marketing, Sales, Medical, BEP and Finance)
• Applies global standards, models, and templates to drive high standards and consistency in analytics and Market Research
• Synthesizes output across research and analytics; presents results of strategic projects (i.e., Resource Allocation, Key Driver Analysis, In-Line Forecasts, Market Research studies) in a coherent, meaningful way
• Contributes to the development and deployment of analytics and Market Research approaches and techniques
• Liaises with Worldwide, other geographies and functional teams for efficient sharing and strategic adoption of learnings and capabilities
• Provides leadership in April and September Projection forecasting process as well as the annual market planning and budgeting process
• Leverages wide variety of Market Research designs and analyses; independently develops non-standard solutions to address complex, multi-faceted issues
• May lead third party contractors

(Disclaimer: The responsibilities listed above are only a summary and other responsibilities will be requirements as assigned)

Requirements

• BA/BS required
• MBA or Master in a quantitative major or concentration preferred
• 5+ years of pharmaceutical/related market experience, including working knowledge of various analytical/Market Research capabilities
• Ability to leverage large, multi-dimensional data sets and qual./quant. Market Research capabilities to drive decisions
• Strong written and verbal (Japanese/English) communication skills: ability to frame issues and present to business stakeholders
• Working knowledge if Microsoft, Excel, Access and PPT
• Preferred: Proficiency and familiarity with analytics/data tools such as SAS, Access, Spotfire, Tableau, SQL, etc.
• Preferred: Knowledge of the pharmaceutical industry and healthcare marketplace dynamics

QA inspector

Description

We are seeking a highly motivated Research Scientist to be part of the IHC & Histology Group in Translational Pathology at the newly opened Cambridge, MA site. Members of this team work on various projects in concert with Discovery, Translational Research, Biomarker, Pathology and Pharmacodiagnostics for further development of the BMS Oncology and other therapeutic area pipelines, contributing to biomarker development, patient stratification strategy for BMS clinical trials and elucidating the mechanism of drug resistance.

The successful candidate will be responsible for the histologic preparation of tissues for evaluation by pathologist(s), including processing, embedding, sectioning and staining with H&E or special stains.   Experience with frozen and FFPE samples is required.  The successful candidate will also be responsible for developing and validating monoplex and multiplex IHC assays, in situ hybridization assays, and image analysis.  She/he will work closely with discovery and translational research scientists, image analysts and pathologists to develop assays, perform disease profiling, and document assay performance in support of their translation to clinical samples. Additional responsibilities include assay technology transfer to CROs and other bioanalytical assays as needed to support Translational Research, as well as contribute to the preparation and presentation of scientific findings.

Job Requirements/Education

• BS required and MS preferred with 3-5 years of relevant experience in life Science discipline. Applicants from academics and industry will be considered. Preference will be given to individuals with previous experience working in the fields of oncology and immunology and working in a GLP or GCLP environment.
• HT or HTL ASCP certification is preferred.  Handling of human tissue samples, both fresh frozen and FFPE is required.
• Proven technical expertise in developing and implementing manual or automated immunohistochemistry and in situ hybridization assays. Experience in whole slide scanning, image analysis and multiplex immunohistochemistry is highly desirable.
• Must be organized and able to work well in a team setting.
• Excellent communication skills, both written and verbal are required.

Bristol-Myers Squibb R&D is a science-driven, passionate organization determined to discover, develop and deliver medicines that have the potential to transform the lives of patients and establish new standards of care in areas of high un-met need. Patients’ needs and scientific discovery are our driving force.   The new Bristol-Myers Squibb research site in Cambridge’s Kendall Square will position our scientific team in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities.  Our scientists will focus on novel targets and pathways for tumors that are refractory to current Immuno-Oncology therapies. These are significant challenges that will require innovative solutions from the biopharma, biotech and academic communities.

Role / Responsibilities

We are seeking an experienced research pathologist to join our Cambridge Translational Pathology group in our new state-of-the-art facility.  The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance the translational medicine efforts. The candidate will play a key role working within a team of histopathology researchers, liaise closely with the Translational Research team to provide pathology and assay development support, and forge strong links across the wider translational medicine, discovery and clinical teams. 

This position requires an MD, or their foreign equivalents, with Board Certification in Anatomic Pathology, or combined Anatomic Pathology/Laboratory Medicine.  A Ph.D. degree in a related field and/or pathology subspecialty certification, in addition to the MD degree, will be highly desirable and a clear demonstration of high quality scholarly productivity in a relevant field of biomedical research is required. We seek candidates with excellent traditional diagnostic pathology skills who demonstrate a strong ability to interpret pathology data in the context of a detailed and current understanding of molecular and cellular biology concepts.  Candidates must have demonstrated their ability to handle several projects at any given time, to work successfully and collaboratively in teams and to communicate clearly both verbally and in writing to a variety of audiences.

Qualifications

• MD/PhD or MD with completion of anatomic pathology and/or clinical pathology residency required. Completion of molecular pathology fellowship is desirable but not essential.
• Experienced pathologist in a translational setting with 2-5+ years’ of post-graduate research experience.
• Participated in clinical studies to better characterize the cellular and molecular underpinnings of therapeutic resistance in patient cohorts and correlation with clinical outcome.
• Strong skill set in developing and implementing multiplexed immunohistochemistry methodologies from antibody selection, staining optimization, pre-analytical variables assessment to downstream digital and imaging strategies with data dissemination and evaluation capabilities.
• Image analysis experience is desired but not a requirement.
• Exposure to cancer immunotherapy including immune-checkpoint blockade with knowledge of current therapeutic landscape is highly desirable.
• Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information, desired but not required.
• Experience with managing CRO relationships and collaborating with KOL’s would be advantageous.
• Excellent interpersonal skills and ability to communicate, both written and oral effectively and efficiently within the BMS organization and with external partners/collaborators.
• Thrives in fast-paced, dynamic work environment, bringing a pro-active mentality to the role.

We follow the science and we will continue to invest in translational medicine research, deepen our understanding of disease biology and uncover insights about predictive biomarkers with the ultimate goal of making precision medicine a reality for more patients.

Summary

The Research Scientist will join the Integrated Oncology Discovery Research team at Bristol-Myers Squibb in Redwood City, CA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology. The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in the oncology, immunology, immuno-oncology, protein engineering/antibody development and medicinal chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.

Position Requirements

• A B.S. degree with a minimum of 8 years or a M.S. degree with a minimum of 6 years of industrial experience with strong scientific knowledge and research experience in cancer biology/cellular and molecular biology as well as experience in immune-oncology.
• Demonstrated independence in experimental design, execution, data analysis and troubleshooting.
• Knowledge of small molecule pre-clinical drug development including knowledge of designing assays and flowcharts to identify and optimize drug candidates.
• Hands on experience with a wide range of in-vitro cellular and biochemical assays, including cell culture, western blotting, immunoprecipitation, ELISAs (MSD), reporter assays, siRNA/shRNA knockdown, CRISPR-mediated genome editing, qPCR, cloning, lentivirus generation and transduction
• Experience with in vivo/ex vivo pharmacology, including working knowledge of in-vivo PK, PD and efficacy studies.
• Experience in data mining through use of desktop tools/interfaces and public databases (e.g., UCSC genome Browser, CBIO, GTex, Oncoland etc).
• Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation.
• Ability to mentor more junior scientists and colleagues on best practices in the laboratory.
• Attention to detail with excellent organizational and record keeping skills.
• Excellent interpersonal skills with ability to interact effectively with people, internally and externally.
• This position is located in Redwood City, CA. There will be less than 10% travel.

Responsibilities:

1.  Performs the assigned activities related to the equipment set-ups, changeovers equipment cleaning, and line clearance to achieve an efficient operation of the different processes and products yield maximizing.

• Operates and understands the preparation, formulation and filling equipment functions and basic troubleshooting activities
• Cleans, sanitize, and sterilize manufacturing area rooms and equipments.
• Runs autoclaves to sterilize equipment to be used in the manufacturing process.
• Performs CIP and SIP (Cleaning in Place and Sterilization in Place) of the tanks.
• Performs integrity test of all filters used in the process before and after each use.
• Receives, handle, verifies and weigh excipients and drug substance and or active ingredient to be used in the formulation process.
• Executes the product formulation as per Batch record and Procedure instructions; this includes pH measurements and adjustments, yield calculations, and volume adjustment.
• Performs sampling of bulk solutions as per batch record requirements.
• Interacts with computer controlled equipment and processes.
• Monitors critical process parameters and proactively takes necessary action to prevent process deviation and/or product losses.
• Verifies calibration status of critical instruments before process operation.
• Operates in an efficient manner of the manufacturing processes to maximize product yield of products.
• Maintains housekeeping within controls and aseptic environments, according to procedures.
• Performs systems integrity test such as isolators, ultra filtration skid, distribution systems, filters and gloves as required. Complete production documentation legible, error free and on time following good documentation practices.

2.   Ensures the completeness and compliance of all required documentation during the manufacturing process.

• Maintains inventory and request all necessary components and operating materials.
• Receives, verifies all production records and transaction documents to be error free and in compliance with established procedures, including computer generated transactions.
• Completes production documentation legible, error free and on time following good documentation practices.
• Audits batch records and documentation, as required.
• Assures that the Compounding equipment is in good working condition, clean, labeled, and calibrated and/or qualified according to applicable SOP’s before performing the formulation process.

Revises and improves procedures and develops new SOPs based on observations and experiences.

3.   Provides assistance and supports to manufacturing related activities

• Initiates, participates, and assists in resolution of quality investigations.
• Assists in “on the job training” for new employees.
• Participates in special projects and during audits and regulatory inspections as required.
• Participates and assists in area validation and qualification activities.
• Supports Environmental Monitoring Program by assuring samples collection on established timeframe.
• Supports Annual Requalification Program by assuring plan execution on established timeframe.     
• Assists manufacturing activities in other areas within operations as required.
• Follows up on progress of activities (e.g. documentation approval) with support departments and inform status to supervision, as requested by supervisor.

4.   Performs GMP Safety and Environmental regulatory tasks required in the manufacturing area.

• Maintains housekeeping within controls and aseptic environments, according to procedures.
• Handles Hazardous and Non hazardous waste according to EHS procedures.
• Attends to all mandatory training meetings for cGMP’s, EHS and Company Policies.

Knowledge/Education/Experience:

• High school diploma with, two (2) years of experience in Parenteral Manufacturing Process  or three (3) years of experience in pharmaceutical manufacturing process.
• Knowledge of preparation, formulation and filling processes.
• Basic writing skills when completing area documentation.
• Basic knowledge on Computerized, PLC control equipment, procedures and new scientific processes.
• Ability to work with minimum supervision.
• Ability to provide job training, theoretical and or On the Job, for new employees following the Parenteral Operations Department Qualification Curriculum.
• Knowledge of all critical process parameters and their impact in product quality.
• Knowledge in steam sterilization, depyrogenation, filtration sterilization, lyophilization and isolators technology. .
• Understanding of Process Equipment set-up and able to perform it repeatedly and according to SOPs.
• Ability to apply critical thinking to resolve complex issues.
• Excellent leadership characteristics, accountability and commitment.
• Team player and collaborating skills.
• Knowledgeable in cGMP’s, process area, documentation, safety, EHS and hygiene practices.
• Skill in performing detailed tasks and documenting information.
• Ability to enter data into a computer and perform complex process transactions.
• Skill in accurate visual inspection (e.g. product and components defects)
• Ability to read procedures and documents in English/Spanish Text (e.g. SOPs, Batch Records, etc.)
• Skill in basic mathematical applications.
• Skill in navigating through and performing transactions in mfg computer systems (HMI, hand held computers).
• Strong organizational skills

The Business Insights & Analytics Rotational Development Program provides recent MS Analytics/MBA graduates with an opportunity to gain valuable work experience while helping various business units meet their objectives.  The program helps to identify potential future business leaders for Bristol-Myers Squibb. 

The BI&A Rotational Development Program spans three years and will include four nine-month assignments, providing exposure to functions across BI&A.  The program ensures associates gain valuable industry and functional experience, contribute meaningfully to teams through challenging assignments, learning opportunities, and networking with senior executives and other employees across the company.  Associates gain experience in the development of business insights & analytics strategies, which they will use to make recommendations with real business impact.  Assignments may include data visualization, market research, data mining, developing data modeling and simulations. 

Upon successful completion of the rotational program, qualified associates will have the opportunity to continue in a full-time role that aligns their area of expertise with business interest.

Position Requirement:

• A Master of Business Administration (MBA) or Masters in Analytics during the current school year, scheduled to graduate in the winter of 2018 or Spring of 2019.
• A minimum of two-three years of relevant business analytics experience preferred.
• An understanding of how to analyze, assess, and provide innovative solutions to broad, complex business issues.
• The ability to draw conclusions from complex situations, then recommend and execute a course of action in both a timely and decisive manner.
• Demonstrated leadership experience either through professional work or in a student, community, or professional organization.
• Excellent written and verbal communication skills, with the ability to organize and present ideas in a convincing and compelling manner to a small or large audience in multiple levels within the organization.
• The ability to work autonomously in small or large teams
• Diverse thinking with innovative ideas and new approaches to maximize opportunities

The Downstream Supervisor leads and drives the execution of commercial manufacturing processes according to established electronic work instructions and production records for the manufacture of therapeutic proteins in accordance with Current Good Manufacturing Practices (cGMP’s). The Supervisor is responsible for management of group whose primary focus is on execution of manufacturing processes, technical assessment of processes, maintaining a culture of compliance, innovation, and within their functional group. The Supervisor is required to guide the personnel in their group with knowledge and technical knowledge to lead troubleshooting activities, provide investigation support, analyze process/equipment data, and identify and implement process improvements.

Responsibilities:

• Provides direct oversight of the execution of manufacturing unit operations. These operations include but are not limited to the use of the following equipment and or systems: i.e. CIP systems, bioreactors, chromatography systems, media/buffer preparation equipment etc.), process automation systems (i.e. Delta V and Syncade Interactions, OSI/Pi Historian) and supporting business systems (i.e. SAP. Trackwise, Maximo etc.).
• Drives right first time (RFT) execution of manufacturing unit operations by providing direct training, guidance, and problem solving on the floor in real time. 
• Responsible for the implementation and execution of Standard Work in all functional areas.
• Takes an active role in selecting and developing the team.  This includes leveraging both internal and external relationships to build the best team possible.
• Takes an active role in developing less experienced Technical Leads.
• Ensures team adherence to Good Manufacturing Practices and standard operating procedures.
• Ensures daily work coordination and distribution as demanded through the manufacturing schedule.
• Is responsible for maintaining schedule adherence and cycle time.
• Reports variances and communicates impact to cross functional groups.
• Manage daily communication to shift personnel.
• Supports and drives shift huddles and functional team meetings. 
• Provides shift handover and Tier communication working with other shift team members.
• Ensures oversight for critical operations through systematic walk down and checks of equipment and functional areas prior to execution.  
• Review critical attributes and drive decisions.
• Act as an area/system owner – a point of contact for all work to be carried out for the area over assigned shift.
• Build partnership with Manufacturing Operational Engineer to ensure daily data review and trends accomplished.
• Provide critical communications upwards, downward and across as deemed fit.
• Manage decisions– acquire feedback, input, and consult as required.
• Ensure shift notes communication is complete and accurate.
• Provide critical update summary to the staff for all safety incidents and significant process deviations.
• Manages performance. Provide coaching, mentoring and development of staff. Conducts powerful conversations and provides meaningful and actionable feedback for staff growth and development. Executes all phases of the performance review process with diligence and on time. Drives continuous improvements through staff engagement
• Demonstrates the ability to lead manufacturing operations teams to achieve objectives. 
• Acts to promote a productive and cooperative climate. 
• Helps to promote team effectiveness by engaging in a trusting, supportive partnership with others. 
• Encourages or facilitates a beneficial resolution of purpose. 
• Resolve conflicts in a constructive manner that allows win/win solution.
• Effectively controls the controllable expenses (OT, Supplies, T&E) within their influence.
• Owns and executes OpEx initiatives including 5S.
• Owns all level 3 investigations occurring on their shift as Lead Investigator.
• Participates as a team member on level 1 and 2 investigations driving and executing appropriate CAPAs.
• Acts as the emergency lead for functional area while on shift.
• Provides direct audit support.
• Acts as a consultant to project teams.

Qualifications:

BS/BA in science – Biology, Biotechnology. Engineering or related discipline - or
        its equivalent is required. 
•    A minimum of 6 years experience in Manufacturing or supporting functions. 
•    Prior supervisory experience preferred. 
•    Extensive knowledge of cGMP regulations and industry best practices. 
•    Demonstrated leadership, interpersonal, communication, motivation skills with strong 
        problem solving and analytical thinking skills. 

Responsibilities:

• Serve as a lead individual contributor within the site Training organization, and a key training resource to the assigned functional area(s).
• Collaborate with functional area representatives, subject matter experts (SMEs) and cross-functional teams to develop and implement key learning strategies and programs in support of site-wide and functionally-driven projects.
• Provide training expertise and consultation in support of the Syracuse training model and process.
• Design and develop training courses as instructor lead and computer based trainings
• Provide guidance, expertise and consulting to functional managers and SMEs in the assessment of training needs, the design of appropriate training and development interventions, the design of implementation plans, and the measurement of training effectiveness.
• Provides guidance around the Electronic Learning Management System functionality.
• Co-facilitates classroom training sessions and learning labs.
• Demonstrates initiative, teamwork, commitment and follow-through with all training initiatives.

Qualifications:

• Knowledge of adult learning and course design generally attained through studies resulting in a Bachelor’s degree in education, instructional design, instructional technology, a related discipline or its equivalent.
• Minimum 2 years relevant life-science industry experience (pharmaceutical/biologics) supporting a manufacturing environment
• Knowledge of biologics manufacturing, GMPs, and support disciplines and the basic principles of each.
• Knowledge and understanding of regulatory and technical training requirements and associated processes.
• 1-2 years experience with utilizing an Electronic Learning Management System, Instructional design, and curricula build experience
• A strong understanding (including practical experience and highly developed skills) with adult learning theory, instructional design and a variety of learning methodologies
• Ability to work collaboratively with all employees at all levels
• Computer skills including MS Word, Excel in Windows NT or higher format with database management
• Project management, problem-solving and decision-making skills
• Ability to perform well in a team-based environment.

We are seeking an Operations/Technical Supervisor I to join the Veterinary Sciences team. As such you will experience a culture that believes in making the animal care and use program a model for the industry. We are focused on providing employees with career development and activities across our entire drug development process.  

Bristol-Myers Squibb is the industry leader in immuno-oncology, Cardiovascular and Fibrosis with life-saving medicines and a rich clinical portfolio of diverse modalities including monoclonal antibody, antibody drug conjugate, fusion protein, and combination regimes.  

Position Responsibilities

Manages the daily operations of multiple animal facilities and specialty area(s) including USDA regulated species, infectious disease/BSL2 areas, and support of in-vivo pharmacology/biology study areas.  

Maintains full ownership of assigned area(s) of responsibility as subject matter expert requiring minimal manager oversight. 

Responsible for upholding regulatory and welfare standards as they pertain to laboratory animal care, husbandry, facilities, and the overall animal macro environment. 

Sets standards and provides guidance on daily operations, animal room preparation, environmental parameters, and relevant reports and takes corrective action as necessary. 

Assists in the oversight of daily activities and development of staff and programs. 

Works with PI’s and staff to optimize workflows for in-vivo studies. 

Reviews staff work assignments and ensures quality performance of assigned tasks.   

Leads the reviews and updates VS Standard Operating Procedures (SOPs) according to the assigned review schedule. 

Manages and develops assigned staff consistent with Company strategy and to achieve departmental objectives. 

Leads supervisory team in developing cross functional capabilities and building team effectiveness.  

Recommends, develops, and delivers training programs for VS employees and research staff on proper techniques required for compliance with research protocols.  

Meets regularly with research staff to assess their research animal needs and appropriately plan for efficient program support. 

Oversees the maintenance, use, disposition, and inventory of equipment for animal care or laboratory activities 

Leverages basic knowledge and understanding of clinical observation and treatment methods to enhance animal care program and health and wellbeing of animals 

Partners with staff to craft development plans in relation to company strategy to achieve departmental objectives.  

Recommends, develops, and delivers training programs to create growth opportunities for VS and research staff  

Supervises the maintenance, use, disposition, and inventory of equipment for animal care or laboratory activities. 

Provides assistance with major project/program activities in the department which may involve multi-site interactions. 

Competencies – Knowledge, Skills, Abilities

The individual is required to have knowledge of experimental methodology, facility operations, and knowledge of regulations and guidelines that govern animal care and use programs. 

Must have mastery of all VS SOPs and a good understanding of related departmental procedures (EH&S, Facilities, etc.) and proficiency in integrating this knowledge with strategic objectives.  

Must have outstanding team building skills and demonstrated leadership and managerial abilities. 

Must have a solid foundation in the care and maintenance of USDA (Animal Welfare Act) regulated species as well as the regulatory requirements for maintaining those animals.  

Must also have a clear understanding accrediting guidelines (The Guide for the Care and Use of Laboratory Animals) and AAALAC for facility operations. 

Experience – Responsibility and minimum number of years

Must have a history of consistent, sustained, high-level performance typically attained with 7-10 years relevant experience in a laboratory animal facility. 

Must have knowledge of the site processes and key contacts such as Medical, HR, investigators, EHS and Facilities required to coordinate project-related activities. 

Must have an excellent understanding of research animal facility operation, to include animal welfare practices, husbandry procedures, animal health and veterinary care, enrichment program, and applicable regulations/accreditations (USDA, AAALAC, OLAW, and site/departmental SOPs). 

Qualifications

Bachelor of Science (BS) in life sciences or an Associates with at least five year of supervisory experience. 

Individual must have AALAS certification at the Laboratory Animal Technologist (LATG) level.  

AALAS Certification at the Certified Manager of Animal Resources (CMAR) is preferred. 

 Masters of Science (MS) in Molecular Biology or Laboratory Animal Science and/or a Masters of Business Administration (MBA) is preferred.