Our performance can be measured in two ways. The most important measure of our success as a global biopharmaceutical company is the difference we make in the lives of patients. In tandem, our ability to ensure the sustainability of our business is often measured by our sales growth.

Our products are sold principally to the wholesale and retail trade. Certain products are also sold to other drug manufacturers, hospitals and the medical profession. Bristol-Myers Squibb is also committed to improving access to our medicines for patients who are unable to afford them.

In 2015, we invested $4.04 billion on pharmaceutical Research and Development, an amount that represents 24.3% percent of our pharmaceutical sales.

Taxes Paid

Bristol-Myers Squibb made provision for $446 million in income taxes in 2015. For more information on taxes paid, refer to the Notes to Consolidated Financial Statements of our Annual Report.

Bristol-Myers Squibb's worldwide sales from continuing operations are shown in the following table:

2013 2014 2015 2014-2015 change
$16.4 billion $15.9 billion $16.6

Our products are available in virtually every country in the world. The company's largest markets include the United States, France, Canada, Japan, Italy, Spain, Germany, China and the United Kingdom.

2015 Sales by Region
United States 49%
Europe 21%
Rest of the World 25%
Other* 5%

*"Other" total revenues include royalties and other alliance-related revenues for products not sold by our regional commercial organizations.