Research publications

Efficacy and Safety of Xanomeline-Trospium Chloride in Schizophrenia: A Randomized Clinical Trial.

Kaul I, Sawchak S, Walling DP, Tamminga CA, Breier A, Zhu H, Miller AC, Paul SM, Brannan SK.

JAMA Psychiatry. 2024 May 1:e240785. doi: 10.1001/jamapsychiatry.2024.0785. Online ahead of print.

PMID: 38691387

 

Adjuvant and post-recurrent treatment patterns in patients with resectable gastric cancer in japan: a retrospective database cohort study.

Yoshikawa T, Kikko Y, Makino R, Kimijima Y, Nishiyama E, Matsuda Y, Casaes Teixeira B, Tejada M, Carroll R, Hironaka S.

Gastric Cancer. 2024 Apr 30. doi: 10.1007/s10120-024-01501-w. Online ahead of print.

PMID: 38689045

 

Pathological response in resectable non-small cell lung cancer: a systematic literature review and meta-analysis.

Waser NA, Quintana M, Schweikert B, Chaft JE, Berry L, Adam A, Vo L, Penrod JR, Fiore J, Berry DA, Goring S.

JNCI Cancer Spectr. 2024 Apr 30;8(3):pkae021. doi: 10.1093/jncics/pkae021.

PMID: 38521542

 

Points to consider regarding the use and implementation of virtual controls in nonclinical general toxicology studies.

Palazzi X, Anger LT, Boulineau T, Grevot A, Guffroy M, Henson K, Hoepp N, Jacobsen M, Kale VP, Kreeger J, Lane JH, Li D, Muster W, Paisley B, Ramaiah L, Robertson N, Shultz V, Steger Hartmann T, Westhouse R.

Regul Toxicol Pharmacol. 2024 Apr 27;150:105632. doi: 10.1016/j.yrtph.2024.105632. Online ahead of print.

PMID: 38679316

 

Implementing multi-level network meta-regression for time-to-event outcomes: A case study in relapsed refractory multiple myeloma.

Maciel D, Jansen JP, Klijn SL, Towle K, Dhanda D, Malcolm B, Cope S.

Value Health. 2024 Apr 26: S1098-3015(24)02349-0. doi: 10.1016/j.jval.2024.04.017. Online ahead of print.

PMID: 38679290

 

Mechanistic studies to understand peak tailing due to sulfinic acid- and carboxylic acid-silanophilic interactions in reversed-phase liquid chromatography.

Zhou Y, Ramirez A, Yuill EM, Wang Q.

J Chromatogr A. 2024 Apr 26;1721:464819. doi: 10.1016/j.chroma.2024.464819. Epub 2024 Mar 15.

PMID: 38537485

 

Effect of hydroxy propyl cellulose grade and foam quality on foam granulation of a high drug load formulation.

Koo O, Patel C, Nikfar F.

Int J Pharm. 2024 Apr 25;657:124171. doi: 10.1016/j.ijpharm.2024.124171. Online ahead of print.

PMID: 38677393

 

Plain Language Summary of the KarMMa-3 study of ide-cel or standard of care regimens in people with relapsed or refractory multiple myeloma.

Rodriguez-Otero P, Ailawadhi S, Arnulf B, Patel K, Cavo M, Nooka AK, Manier S, Callander N, Costa LJ, Vij R, Bahlis NJ, Moreau P, Solomon SR, Delforge M, Berdeja J, Truppel-Hartmann A, Yang Z, Favre-Kontula L, Wu F, Piasecki J, Cook M, Giralt S.

Future Oncol. 2024 Apr 23. doi: 10.2217/fon-2023-0954. Online ahead of print.

PMID: 38651976

 

Comparative Pharmacokinetics and Safety Assessment of 1st- and 2nd-Generation Zinpentraxin Alfa Drug Products in Healthy Volunteers: A Randomized Crossover Study.

Mai TH, Yadav R, Arjomandi A, Jung C, Meier MM, Donaldson F, Zhao R, Ding HT, Hsu JC, Kamath N, Pan L.

Clin Pharmacol Drug Dev. 2024 Apr 23. doi: 10.1002/cpdd.1403. Online ahead of print.

PMID: 38651245

 

Overcoming Lot-to-Lot Variability in Protein Activity Using Epitope-Specific Calibration-Free Concentration Analysis.

Harvey IB, Chilewski SD, Bhosale D, Tobia SE, Gray C, Gleason C, Haulenbeek J.

Anal Chem. 2024 Apr 23;96(16):6275-6281. doi: 10.1021/acs.analchem.3c05607. Epub 2024 Apr 10.

PMID: 38600735

 

Nivolumab plus cabozantinib versus sunitinib for first-line treatment of advanced renal cell carcinoma: extended follow-up from the phase III randomised CheckMate 9ER trial.

Powles T, Burotto M, Escudier B, Apolo AB, Bourlon MT, Shah AY, Suárez C, Porta C, Barrios CH, Richardet M, Gurney H, Kessler ER, Tomita Y, Bedke J, George S, Scheffold C, Wang P, Fedorov V, Motzer RJ, Choueiri TK.

ESMO Open. 2024 Apr 19;9(5):102994. doi: 10.1016/j.esmoop.2024.102994. Online ahead of print.

PMID: 38642472

 

The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading.

Sudhakar N, Yan L, Qiryaqos F, Engstrom LD, Laguer J, Calinisan A, Hebbert A, Waters L, Moya K, Bowcut V, Vegar L, Ketcham JM, Ivetac A, Smith CR, Lawson JD, Rahbaek L, Clarine J, Nguyen N, Saechao B, Parker C, Elliott AJ, Vanderpool D, He L, Hover LD, Fernandez-Banet J, Coma S, Pachter JA, Hallin J, Marx MA, Briere DM, Christensen JG, Olson P, Haling J, Khare S.

Mol Cancer Ther. 2024 Apr 19. doi: 10.1158/1535-7163.MCT-23-0870. Online ahead of print.

PMID: 38641404

 

α-Alkylation and Asymmetric Transfer Hydrogenation of Tetralone via Hydrogen Borrowing and Dynamic Kinetic Resolution Strategy Using a Single Iridium(III) Complex.

Kim SW, Foker EA, Wolf WJ, Woltornist RA, Shemet A, McCowen S, Simmons EM, Lin Z, He BL, Menger R, Xu X, Ayers S, Bunner MH, Sarjeant AA.

Org Lett. 2024 Apr 19;26(15):3103-3108. doi: 10.1021/acs.orglett.4c00718. Epub 2024 Apr 8.

PMID: 38588485

 

Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity.

De Alwis D, Foley CM, Herman E, Hill AP, Hoffmann PK, Kanda Y, Kaushik E, Pierson J, Puglisi R, Shi H, Yang X, Pugsley MK.

J Pharmacol Toxicol Methods. 2024 Apr 16:107507. doi: 10.1016/j.vascn.2024.107507. Online ahead of print.

PMID: 38636673

 

Long-Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER-OLE Study.

Masri A, Lester SJ, Stendahl JC, Hegde SM, Sehnert AJ, Balaratnam G, Shah A, Fox S, Wang A.

J Am Heart Assoc. 2024 Apr 16;13(8):e030607. doi: 10.1161/JAHA.123.030607. Epub 2024 Apr 9.

PMID: 38591260

 

Development of Patient and Caregiver Conceptual Models Investigating the Health-Related Quality of Life Impacts of Malignant Pleural Mesothelioma.

Gibson AEJ, Ahmed W, Longworth L, Bennett B, Daumont M, Darlison L.

Patient. 2024 Apr 15. doi: 10.1007/s40271-024-00690-x. Online ahead of print.

PMID: 38619810

 

Simplifying Access to Targeted Protein Degraders via Nickel Electrocatalytic Cross-Coupling.

Neigenfind P, Massaro L, Péter Á, Degnan AP, Emmanuel MA, Oderinde MS, He C, Peters D, El-Hayek Ewing T, Kawamata Y, Baran PS.

Angew Chem Int Ed Engl. 2024 Apr 15;63(16):e202319856. doi: 10.1002/anie.202319856. Epub 2024 Mar 7.

PMID: 38354272

 

Understanding the Impact of Combined Hydrodynamic Shear and Interfacial Dilatational Stress, on Interface-Mediated Particle Formation for Monoclonal Antibody Formulations.

Griffin VP, Pace S, Ogunyankin MO, Holstein M, Hung J, Dhar P.

J Pharm Sci. 2024 Apr 12:S0022-3549(24)00138-2. doi: 10.1016/j.xphs.2024.04.009. Online ahead of print.

PMID: 38615816

 

Human Genetics and Genomics for Drug Target Identification and Prioritization: Open Targets' Perspective.

McDonagh EM, Trynka G, McCarthy M, Holzinger ER, Khader S, Nakic N, Hu X, Cornu H, Dunham I, Hulcoop D.

Annu Rev Biomed Data Sci. 2024 Apr 12. doi: 10.1146/annurev-biodatasci-102523-103838. Online ahead of print.

PMID: 38608311 Review.

 

Balanced Permeability Index: A Multiparameter Index for Improved In Vitro Permeability.

Weiss DR, Baylon JL, Evans ED, Paiva A, Everlof G, Cutrone J, Broccatelli F.

ACS Med Chem Lett. 2024 Mar 19;15(4):457-462. doi: 10.1021/acsmedchemlett.3c00542. eCollection 2024 Apr 11.

PMID: 38628792

 

Hydrolysis of Cellulose Acetate Phthalate and Hydroxypropyl Methylcellulose Phthalate in Amorphous Solid Dispersions.

Li J, Yu D, Zeng C, Mosquera-Giraldo LI, Everlof G, Foster K, Gesenberg C.

J Pharm Sci. 2024 Apr 10:S0022-3549(24)00133-3. doi: 10.1016/j.xphs.2024.04.006. Online ahead of print.

PMID: 38608727

 

(Phenoxyimine)nickel-Catalyzed C(sp²)-C(sp³) Suzuki-Miyaura Cross-Coupling: Evidence for a Recovering Radical Chain Mechanism.

Mills LR, Simmons EM, Lee H, Nester E, Kim J, Wisniewski SR, Pecoraro MV, Chirik PJ.

J Am Chem Soc. 2024 Apr 10;146(14):10124-10141. doi: 10.1021/jacs.4c01474. Epub 2024 Apr 1.

PMID: 38557045

 

A new insight into the mechanism of the tabletability flip phenomenon.

Wang Z, Wang C, Guo Y, Bahl D, Fok A, Sun CC.

Int J Pharm. 2024 Apr 10;654:123956. doi: 10.1016/j.ijpharm.2024.123956. Epub 2024 Feb 28.

PMID: 38428547

 

Behavioral Science: Enhancing Our Approach to the Development of Effective Additional Risk Minimization Strategies.

Treacy J, Morrato EH, Horne R, Wolf MS, Bakhai A, Wilson MC, Lightowler M, Guerler S, Jokinen J.

Drug Saf. 2024 Apr 9. doi: 10.1007/s40264-024-01420-w. Online ahead of print.

PMID: 38594553

 

Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles.

Long SA, Muir VS, Jones BE, Wall VZ, Ylescupidez A, Hocking AM, Pribitzer S, Thorpe J, Fuchs B, Wiedeman AE, Tatum M, Lambert K, Uchtenhagen H, Speake C, Ng B, Heubeck AT, Torgerson TR, Savage AK, Maldonado MA, Ray N, Khaychuk V, Liu J, Linsley PS, Buckner JH.

Front Immunol. 2024 Apr 8;15:1383110. doi: 10.3389/fimmu.2024.1383110. eCollection 2024.

PMID: 38650930

 

Concerted transformation of a hyper-paused transcription complex and its reinforcing protein.

Zuber PK, Said N, Hilal T, Wang B, Loll B, González-Higueras J, Ramírez-Sarmiento CA, Belogurov GA, Artsimovitch I, Wahl MC, Knauer SH.

Nat Commun. 2024 Apr 8;15(1):3040. doi: 10.1038/s41467-024-47368-4.

PMID: 38589445

 

Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer.

Yaeger R, Uboha NV, Pelster MS, Bekaii-Saab TS, Barve M, Saltzman J, Sabari JK, Peguero JA, Paulson AS, Jänne PA, Cruz-Correa M, Anderes K, Velastegui K, Yan X, Der-Torossian H, Klempner SJ, Kopetz SE.

Cancer Discov. 2024 Apr 8:OF1-OF12. doi: 10.1158/2159-8290.CD-24-0217. Online ahead of print.

PMID: 38587856

DeepLoc 2.1: multi-label membrane protein type prediction using protein language models.

Ødum MT, Teufel F, Thumuluri V, Almagro Armenteros JJ, Johansen AR, Winther O, Nielsen H.

Nucleic Acids Res. 2024 Apr 8:gkae237. doi: 10.1093/nar/gkae237. Online ahead of print.

PMID: 38587188

 

Real-World Experience and 36-Week Outcomes of Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten.

Reza N, Dubey A, Carattini T, Marzolf A, Hornsby N, de Feria A, Mahmud N, Schuler P, Owens AT.

JACC Heart Fail. 2024 Apr 7:S2213-1779(24)00263-4. doi: 10.1016/j.jchf.2024.03.009. Online ahead of print.

PMID: 38661589

 

Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis.

Kekessie I, Wegner K, Martinez I, Kopach ME, White TD, Tom JK, Kenworthy MN, Gallou F, Lopez J, Koenig SG, Payne PR, Eissler S, Arumugam B, Li C, Mukherjee S, Isidro-Llobet A, Ludemann-Hombourger O, Richardson P, Kittelmann J, Sejer Pedersen D, van den Bos LJ.

J Org Chem. 2024 Apr 5;89(7):4261-4282. doi: 10.1021/acs.joc.3c01494. Epub 2024 Mar 20.

PMID: 38508870

 

Anhydrous and Stereoretentive Fluoride-Enhanced Suzuki-Miyaura Coupling of Immunomodulatory Imide Drug Derivatives.

Tracy WF, Davies GHM, Grant LN, Ganley JM, Moreno J, Cherney EC, Davies HML.

J Org Chem. 2024 Apr 5;89(7):4595-4606. doi: 10.1021/acs.joc.3c02873. Epub 2024 Mar 7.

PMID: 38452367 

 

Different Development Strategies Affecting Japan's Drug lag between Japan-Based and Foreign-Based Companies.

Hidaka M, Hanaoka H, Uyama Y.

Ther Innov Regul Sci. 2024 Apr 4. doi: 10.1007/s43441-024-00649-y. Online ahead of print.

PMID: 38575785

 

PmWebSpec: An Application to Create and Manage CDISC-Compliant Pharmacometric Analysis Dataset Specifications.

Chen L, Dombrowsky E, Boyle B, Tang C, Thanneer N.

AAPS J. 2024 Apr 3;26(3):39. doi: 10.1208/s12248-024-00910-0.

PMID: 38570385

 

Ozanimod Differentially Impacts Circulating Lymphocyte Subsets in Patients with Moderately to Severely Active Crohn's Disease.

Harris S, Feagan BG, Hanauer S, Vermeire S, Ghosh S, Yan J, Wu C, Hu Y, Maddux R, Wolf DC, D'Haens G.

Dig Dis Sci. 2024 Apr 3. doi: 10.1007/s10620-024-08391-z. Online ahead of print.

PMID: 38568396

 

Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors.

Pecci F, Nakazawa S, Ricciuti B, Harada G, Lee JK, Alessi JV, Barrichello A, Vaz VR, Lamberti G, Di Federico A, Gandhi MM, Gazgalis D, Feng WW, Jiang J, Baldacci S, Locquet MA, Gottlieb FH, Chen MF, Lee E, Haradon D, Smokovich A, Voligny E, Nguyen T, Goel VK, Zimmerman Z, Atwal S, Wang X, Bahcall M, Heist RS, Iqbal S, Gandhi N, Elliott A, Vanderwalde AM, Ma PC, Halmos B, Liu SV, Che J, Schrock AB, Drilon A, Janne PA, Awad MM.

Cancer Discov. 2024 Apr 3. doi: 10.1158/2159-8290.CD-23-1217. Online ahead of print.

PMID: 38564707

 

Assessment of CYP-Mediated Drug Interactions for Enasidenib Based on a Cocktail Study in Patients with Relapse or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome.

Cheng Y, Wang X, Ghosh A, Pu J, Carayannopoulos LN, Li Y.

J Clin Pharmacol. 2024 Apr 2. doi: 10.1002/jcph.2436. Online ahead of print.

PMID: 38563070

 

Abatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19: A Secondary Analysis of the ACTIV-1 IM Randomized Clinical Trial.

Balevic SJ, Benjamin DK Jr, Powderly WG, Smith PB, Gonzalez D, McCarthy MW, Shaw LK, Lindsell CJ, Bozzette S, Williams D, Linas BP, Blamoun J, Javeri H, Hornik CP; ACTIV-1 IM Study Group.

JAMA Netw Open. 2024 Apr 1;7(4):e247615. doi: 10.1001/jamanetworkopen.2024.7615.

PMID: 38662372

 

Scoring PD-L1 Expression in Urothelial Carcinoma: An International Multi-Institutional Study on Comparison of Manual and Artificial Intelligence Measurement Model (AIM-PD-L1) Pathology Assessments.

Rüschoff J, Kumar G, Badve S, Jasani B, Krause E, Rioux-Leclercq N, Rojo F, Martini M, Cheng L, Tretiakova M, Mitchell C, Anders RA, Robert ME, Fahy D, Pyle M, Le Q, Yu L, Glass B, Baxi V, Babadjanova Z, Pratt J, Brutus S, Karasarides M, Hartmann A.

Virchows Arch. 2024 Apr;484(4):597-608. doi: 10.1007/s00428-024-03795-8. Epub 2024 Apr 4.

PMID: 38570364

 

A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic.

Cohen JR, Brych SR, Prabhu S, Bi V, Elbaradei A, Tokuda JM, Xiang C, Hokom M, Cui X, Ly C, Amos N, Sun J, Calamba D, Herskovitz J, Capili A, Nourbakhsh K, Merlo A, Carreon J, Wypych J, Narhi LO, Jawa V, Joubert MK.

Pharm Res. 2024 Apr;41(4):651-672. doi: 10.1007/s11095-024-03678-2. Epub 2024 Mar 22.

PMID: 38519817

 

Defining a standard set of health outcomes for patients with relapsing-remitting multiple sclerosis.

Llaneza González M, Carrascal Rueda P, Delgado Sánchez O, Borges Guerra M, Rodríguez Antigüedad A, Morell Baladrón A, Becerril Ríos N, Rovira À, Meca Lallana V, Benedito-Palos L, Comellas M, Vilanova D, Echeto A, Pérez X, Oreja-Guevara C.

Mult Scler Relat Disord. 2024 Apr;84:105501. doi: 10.1016/j.msard.2024.105501. Epub 2024 Feb 13.

PMID: 38401203

 

Risk of Venous Thromboembolism by Cancer Type: A Network Meta-Analysis.

Betts MB, Liu X, Junqueira DR, Fahrbach K, Neupane B, Ronnebaum S, Dhamane AD.

Semin Thromb Hemost. 2024 Apr;50(3):328-341. doi: 10.1055/s-0044-1779672. Epub 2024 Feb 23.

PMID: 38395064

 

2023 White Paper on Recent Issues in Bioanalysis: ISR for ADA Assays, the Rise of dPCR vs qPCR, International Reference Standards for Vaccine Assays, Anti-AAV TAb Post-Dose Assessment, NanoString Validation, ELISpot as Gold Standard (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccines Immunogenicity & Technologies; Biotherapeutics Immunogenicity & Risk Assessment; ADA/NAb Assay/Reporting Harmonization).

Mora J, Palmer R, Wagner L, Wu B, Partridge M, Meena, Sonderegger I, Smeraglia J, Bivi N, Dakappagari N, Diebold S, Garofolo F, Grimaldi C, Kalina W, Kamerud J, Kar S, Marshall JC, Mayer C, Melton A, Merdek K, Nolan K, Picard S, Shao W, Seitzer J, Tanaka Y, Tounekti O, Vigil A, Walravens K, Xu J, Xu W, Xu Y, Yang L, Zhu L, Verthelyi D, Kubiak RJ, Coble K, Gupta S, Abhari MR, Richards S, Song Y, Ullmann M, Calderon B, Cludts I, Gunn GR, Gupta S, Ishii-Watabe A, Manangeeswaran M, Maxfield K, McCush F, O'Day C, Peng K, Poetzl J, Rasamoelisolo M, Saad OM, Scheibner K, Shubow S, Song S, Thacker S.

Bioanalysis. 2024 Apr;16(7):77-119. doi: 10.4155/bio-2024-0024. Epub 2024 Feb 22.

PMID: 38389403 

 

Influence of the COVID-19 pandemic on patients receiving oral anticoagulants for the treatment of non-valvular atrial fibrillation.

Comín Colet J, Sicras Mainar A, Salazar-Mendiguchía J, Isabel Del Campo Alonso M, Echeto A, Vilanova Larena D, Delgado Sánchez O.

Int J Cardiol Heart Vasc. 2024 Feb 10;51:101358. doi: 10.1016/j.ijcha.2024.101358. eCollection 2024 Apr.

PMID: 38371309 

 

PAR4 Antagonism in Patients With Coronary Artery Disease Receiving Antiplatelet Therapies.

Nash J, Meah MN, Whittington B, Debono S, Raftis J, Miller MR, Sorbie A, Mills NL, Nespoux J, Bruce L, Duffin R, Dhaun N, Brittan M, Chao L, Merali S, Kim M, Wang Z, Zhang Y, Jin S, Wang B, Kozinn M, Newby DE.

Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):987-996. doi: 10.1161/ATVBAHA.123.320448. Epub 2024 Feb 15.

PMID: 38357820 

 

An industry perspective approach and control strategy for implementation of ready-to-use cells in bioassays: survey outcome and recommendations.

White JR, Ahmed S, Amstrup J, Bennington P, Cheng ZJ, Day P, Haenssen KK, Kozminsky-Atias A, Martinez E, Ong EH, Qahwash I, Stokes ES, Wang J.

Biotechniques. 2024 Apr;76(4):135-144. doi: 10.2144/btn-2023-0086. Epub 2024 Feb 9.

PMID: 38334496 

 

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference.

Linz D, Andrade JG, Arbelo E, Boriani G, Breithardt G, Camm AJ, Caso V, Nielsen JC, De Melis M, De Potter T, Dichtl W, Diederichsen SZ, Dobrev D, Doll N, Duncker D, Dworatzek E, Eckardt L, Eisert C, Fabritz L, Farkowski M, Filgueiras-Rama D, Goette A, Guasch E, Hack G, Hatem S, Haeusler KG, Healey JS, Heidbuechel H, Hijazi Z, Hofmeister LH, Hove-Madsen L, Huebner T, Kääb S, Kotecha D, Malaczynska-Rajpold K, Merino JL, Metzner A, Mont L, Ng GA, Oeff M, Parwani AS, Puererfellner H, Ravens U, Rienstra M, Sanders P, Scherr D, Schnabel R, Schotten U, Sohns C, Steinbeck G, Steven D, Toennis T, Tzeis S, van Gelder IC, van Leerdam RH, Vernooy K, Wadhwa M, Wakili R, Willems S, Witt H, Zeemering S, Kirchhof P.

Europace. 2024 Mar 30;26(4):euae070. doi: 10.1093/europace/euae070.

PMID: 38591838 

 

Focused ultrasound-mediated blood-brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma.

Tazhibi M, McQuillan N, Wei HJ, Gallitto M, Bendau E, Webster Carrion A, Berg X, Kokossis D, Zhang X, Zhang Z, Jan CI, Mintz A, Gartrell RD, Syed HR, Fonseca A, Pavisic J, Szalontay L, Konofagou EE, Zacharoulis S, Wu CC.

J Transl Med. 2024 Mar 30;22(1):320. doi: 10.1186/s12967-024-05096-9.

PMID: 38555449

 

Association of Insomnia and Obstructive Sleep Apnea with Worse Oral Mucositis and Quality of Life in Head and Neck Cancer Patients Undergoing Radiation Therapy.

Iovoli AJ, Smith K, Yu H, Kluczynski MA, Jungquist CR, Ray AD, Farrugia MK, Gu F, Singh AK.

Cancers (Basel). 2024 Mar 29;16(7):1335. doi: 10.3390/cancers16071335.

PMID: 38611012 

 

Plain language summary of the TRANSFORM study primary analysis results: lisocabtagene maraleucel as a second treatment regimen for large B-cell lymphoma following failure of the first treatment regimen.

Abramson JS, Solomon SR, Arnason J, Johnston PB, Glass B, Bachanova V, Ibrahimi S, Mielke S, Mutsaers P, Hernandez-Ilizaliturri F, Izutsu K, Morschhauser F, Lunning M, Crotta A, Montheard S, Previtali A, Ogasawara K, Kamdar M.

Future Oncol. 2024 Mar 28. doi: 10.2217/fon-2023-0898. Online ahead of print.

PMID: 38547003 

 

Patient experience of medication administration and development of a Patient Experience and Preference Questionnaire (PEPQ) for patients with advanced or metastatic cancer.

Skalicky A, Bennett B, Raimbourg J, Lonardi S, Correll J, Lugowska I, Dixon M, Sargalo N, Martin ML.

Front Pharmacol. 2024 Mar 27;15:1310546. doi: 10.3389/fphar.2024.1310546. eCollection 2024.

PMID: 38601466 

 

Modeling scalability of impurity precipitation in downstream biomanufacturing.

Guo J, Traylor SJ, Agoub M, Jin W, Hua H, Diemer RB, Xu X, Ghose S, Li ZJ, Lenhoff AM.

Biotechnol Prog. 2024 Mar 27:e3454. doi: 10.1002/btpr.3454. Online ahead of print.

PMID: 38539261

 

Improvements in Patient-Reported Outcomes After Treatment With Deucravacitinib in Patients With Psoriatic Arthritis: Results From a Randomized Phase 2 Trial.

Strand V, Gossec L, Coates LC, Ogdie A, Choi J, Becker B, Zhuo J, Lehman T, Nowak M, Elegbe A, Mease PJ, Deodhar A.

Arthritis Care Res (Hoboken). 2024 Mar 26. doi: 10.1002/acr.25333. Online ahead of print.

PMID: 38529674

 

Directional ΔG Neural Network (DrΔG-Net): A Modular Neural Network Approach to Binding Free Energy Prediction.

Metcalf DP, Glick ZL, Bortolato A, Jiang A, Cheney DL, Sherrill CD.

J Chem Inf Model. 2024 Mar 25;64(6):1907-1918. doi: 10.1021/acs.jcim.3c02054. Epub 2024 Mar 12.

PMID: 38470995 

 

Muscarinic Receptor Activators as Novel Treatments for Schizophrenia.

Paul SM, Yohn SE, Brannan SK, Neugebauer NM, Breier A.

Biol Psychiatry. 2024 Mar 25:S0006-3223(24)01173-9. doi: 10.1016/j.biopsych.2024.03.014. Online ahead of print.

PMID: 38537670 

 

Patient Characteristics, Treatment Patterns, and Outcomes for Patients With Renal Cell Carcinoma in England: A Retrospective Cohort Study.

Das P, Booth A, Donaldson R, Berfeld N, Nordstrom B, Carroll R, Dhokia P, Clark A, Vaz L.

Clin Genitourin Cancer. 2024 Mar 22:102081. doi: 10.1016/j.clgc.2024.102081. Online ahead of print.

PMID: 38641444 

 

SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia.

Moison C, Gracias D, Schmitt J, Girard S, Spinella JF, Fortier S, Boivin I, Mendoza-Sanchez R, Thavonekham B, MacRae T, Mayotte N, Bonneil E, Wittman M, Carmichael J, Ruel R, Thibault P, Hébert J, Marinier A, Sauvageau G.

Sci Adv. 2024 Mar 22;10(12):eadl4018. doi: 10.1126/sciadv.adl4018. Epub 2024 Mar 22.

PMID: 38517966 

 

Challenges of Incorporating Life Cycle Drug Pricing in Cost-Effectiveness Models: A Review of Methods and Modeling Suggestions.

Puls M, Horscroft J, Kearns B, Gladwell D, Church E, Johannesen K, Malcolm B, Borrill J.

Value Health. 2024 Mar 20:S1098-3015(24)00121-9. doi: 10.1016/j.jval.2024.03.006. Online ahead of print.

PMID: 38513883 

 

Safety and Effectiveness of Elotuzumab in Japanese Patients with Relapsed/Refractory Multiple Myeloma: A Post-marketing Surveillance Study.

Kaneko F, Suzuka H, Yoshino T, Hinosugi R.

Intern Med. 2024 Mar 18. doi: 10.2169/internalmedicine.2487-23. Online ahead of print.

PMID: 38494720 

 

Accelerating the development of genetically engineered cellular therapies: a framework for extrapolating data across related products.

Stewart MD, Kalos M, Coutinho V, Better M, Jazayeri J, Yohrling J, Jadlowsky J, Fuchs M, Gidwani S, Goessl C, Hanley PJ, Healy J, Liu W, McKelvey BA, Pearce L, Pilon-Thomas S, Andrews HS, Veldman M, Vong J, Weinbach SP, Allen JD.

Cytotherapy. 2024 Mar 16:S1465-3249(24)00097-5. doi: 10.1016/j.jcyt.2024.03.009. Online ahead of print.

PMID: 38583170 

 

Science- and Risk-Based Stability Strategies to Support Product Lifecycle Changes.

McCaig L, Nowak S, Abbott A, Carhart J, McMahon ME, Debie E, Li H, Maina F, Ji AJ, Fu M, Wu Y, Lennard A, Mazzeo T, Wolfe C, Timpano R, Babayan Y, Gruenig L.

AAPS J. 2024 Mar 14;26(2):34. doi: 10.1208/s12248-024-00903-z.

PMID: 38485849

 

Phase 2, Double-Blind, Placebo-controlled Trial of a c-Jun N-Terminal Kinase Inhibitor in Idiopathic Pulmonary Fibrosis.

Mattos WLLD, Khalil N, Spencer LG, Bonella F, Folz RJ, Rolf JD, Mogulkoc N, Lancaster LH, Jenkins RG, Lynch DA, Noble PW, Maher TM, Cottin V, Senger S, Horan GS, Greenberg S, Popmihajlov Z.

Am J Respir Crit Care Med. 2024 Mar 14. doi: 10.1164/rccm.202310-1907OC. Online ahead of print.

PMID: 38484130

 

Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis.

Zhang X, Jiang W, Richter JM, Bates JA, Reznik SK, Stachura S, Rampulla R, Doddalingappa D, Ulaganathan S, Hua J, Bostwick JS, Sum C, Posy S, Malmstrom S, Dickey J, Harden D, Lawrence RM, Guarino VR, Schumacher WA, Wong P, Yang J, Gordon DA, Wexler RR, Priestley ES.

J Med Chem. 2024 Mar 14;67(5):3571-3589. doi: 10.1021/acs.jmedchem.3c01986. Epub 2024 Feb 22.

PMID: 38385264

 

Modified FOLFOX6 plus bevacizumab with and without nivolumab for first-line treatment of metastatic colorectal cancer: phase 2 results from the CheckMate 9X8 randomized clinical trial.

Lenz HJ, Parikh A, Spigel DR, Cohn AL, Yoshino T, Kochenderfer M, Elez E, Shao SH, Deming D, Holdridge R, Larson T, Chen E, Mahipal A, Ucar A, Cullen D, Baskin-Bey E, Kang T, Hammell AB, Yao J, Tabernero J.

J Immunother Cancer. 2024 Mar 13;12(3):e008409. doi: 10.1136/jitc-2023-008409.

PMID: 38485190 

 

Author Correction: Shallow shotgun sequencing reduces technical variation in microbiome analysis.

La Reau AJ, Strom NB, Filvaroff E, Mavrommatis K, Ward TL, Knights D.

Sci Rep. 2024 Mar 13;14(1):6116. doi: 10.1038/s41598-024-56475-7.

PMID: 38480754 

 

Integrating Full Bayesian Inference and Student's t-Distribution Method for Enhanced Outlier Handling in Caffeine Population Pharmacokinetics: Assessing Drug-Drug Interactions with Enasidenib in Relapsed or Refractory AML and MDS Patients.

Cheng Y, Du S, Hu H, Wang X, Carayannopoulos L, Li Y.

J Clin Pharmacol. 2024 Mar 13. doi: 10.1002/jcph.2426. Online ahead of print.

PMID: 38478303

 

Correction: Complex peptide macrocycle optimization: combining NMR restraints with conformational analysis to guide structure-based and ligand-based design.

Jain AN, Brueckner AC, Jorge C, Cleves AE, Khandelwal P, Cortes JC, Mueller L.

J Comput Aided Mol Des. 2024 Mar 13;38(1):12. doi: 10.1007/s10822-024-00556-2.

PMID: 38472529 

 

Deep Learning-Assisted Automated Multidimensional Single Particle Tracking in Living Cells.

Song D, Zhang X, Li B, Sun Y, Mei H, Cheng X, Li J, Cheng X, Fang N.

Nano Lett. 2024 Mar 13;24(10):3082-3088. doi: 10.1021/acs.nanolett.3c04870. Epub 2024 Feb 28.

PMID: 38416583

 

Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's disease.

Summa KC, Jiang P, González-Rodríguez P, Huang X, Lin X, Vitaterna MH, Dan Y, Surmeier DJ, Turek FW.

NPJ Parkinsons Dis. 2024 Mar 11;10(1):54. doi: 10.1038/s41531-024-00670-w.

PMID: 38467673 

 

A Methodological Study to Compare Alternative Modes of Administration with Value EQ-5D Using Preference-Elicitation Techniques.

Hill SR, Gibson A, Oluboyede Y, Longworth L, Bennett B, Shaw JW.

Value Health. 2024 Mar 10:S1098-3015(24)00093-7. doi: 10.1016/j.jval.2024.02.020. Online ahead of print.

PMID: 38467189

 

Final results of urelumab, an anti-CD137 agonist monoclonal antibody, in combination with cetuximab or nivolumab in patients with advanced solid tumors.

Khushalani NI, Ott PA, Ferris RL, Cascone T, Schadendorf D, Le DT, Sharma MR, Barlesi F, Sharfman W, Luke JJ, Melero I, Lathers D, Neely J, Suryawanshi S, Sanyal A, Holloway JL, Suryawanshi R, Ely S, Segal NH.

J Immunother Cancer. 2024 Mar 7;12(3):e007364. doi: 10.1136/jitc-2023-007364.

PMID: 38458639

 

Deucravacitinib in moderate-to-severe plaque psoriasis: Pooled safety and tolerability over 52 weeks from two phase 3 trials (POETYK PSO-1 and PSO-2).

Strober B, Blauvelt A, Warren RB, Papp KA, Armstrong AW, Gordon KB, Morita A, Alexis AF, Lebwohl M, Foley P, Kisa RM, Colston E, Wang T, Banerjee S, Thaçi D.

J Eur Acad Dermatol Venereol. 2024 Mar 7. doi: 10.1111/jdv.19925. Online ahead of print.

PMID: 38451052

 

Disease-modifying anti-rheumatic drug selection in Japanese patients with rheumatoid arthritis treated with biologics or JAK inhibitors without methotrexate: A retrospective hospital-based administrative claims database study.

Miyakawa N, Tsuritani K, Teixeira BC, Fujio K.

Mod Rheumatol. 2024 Mar 7:roae021. doi: 10.1093/mr/roae021. Online ahead of print.

PMID: 38450776

 

Simplified Modular Access to Enantiopure 1,2-Aminoalcohols via Ni-Electrocatalytic Decarboxylative Arylation.

Sun J, Endo H, Emmanuel MA, Oderinde MS, Kawamata Y, Baran PS.

J Am Chem Soc. 2024 Mar 6;146(9):6209-6216. doi: 10.1021/jacs.3c14119. Epub 2024 Feb 22.

PMID: 38387466

 

Evaluating the effect of inequalities in oral anti-coagulant prescribing on outcomes in people with atrial fibrillation.

Mulholland RJ, Manca F, Ciminata G, Quinn TJ, Trotter R, Pollock KG, Lister S, Geue C.

Eur Heart J Open. 2024 Mar 5;4(2):oeae016. doi: 10.1093/ehjopen/oeae016. eCollection 2024 Mar.

PMID: 38572087

 

A propensity score-integrated approach for leveraging external data in a randomized controlled trial with time-to-event endpoints.

Chen WC, Lu N, Wang C, Li H, Song C, Tiwari R, Xu Y, Yue LQ.

Pharm Stat. 2024 Mar 5. doi: 10.1002/pst.2377. Online ahead of print.

PMID: 38442919

 

Proteomic Associations of Adverse Outcomes in Human Heart Failure.

Dib MJ, Levin MG, Zhao L, Diab A, Wang Z, Ebert C, Salman O, Azzo JD, Gan S, Zamani P, Cohen JB, Gill D, Burgess S, Zagkos L, van Empel V, Richards AM, Doughty R, Rietzschel ER, Kammerhoff K, Kvikstad E, Maranville J, Schafer P, Seiffert DA, Ramirez-Valle F, Gordon DA, Chang CP, Javaheri A, Mann DL, Cappola TP, Chirinos JA.

J Am Heart Assoc. 2024 Mar 5;13(5):e031154. doi: 10.1161/JAHA.123.031154. Epub 2024 Feb 29.

PMID: 38420755 

 

Two-year treatment persistence with subcutaneous abatacept in rheumatoid arthritis: results from the French cohort of the ASCORE study.

Flipo RM, Constantin A, Goupille P, Chartier M, Ohayon A, Mariette X.

Clin Exp Rheumatol. 2024 Mar 3. doi: 10.55563/clinexprheumatol/ddx0fz. Online ahead of print.

PMID: 38436358

 

An innovative hybrid modeling approach for simultaneous prediction of cell culture process dynamics and product quality.

Polak J, Huang Z, Sokolov M, von Stosch M, Butté A, Hodgman CE, Borys M, Khetan A.

Biotechnol J. 2024 Mar;19(3):e2300473. doi: 10.1002/biot.202300473.

PMID: 38528367

 

Ensuring Stakeholder Feedback in the Design and Conduct of Clinical Trials for Rare Diseases: ISCTM Position Paper of the Orphan Disease Working Group.

Pandina GJ, Busner J, Kempf L, Fallon J, Alphs LD, Acosta MT, Berger AK, Day S, Dunn J, Villalta-Gil V, Grabb MC, Horrigan JP, Jacobson W, Kando JC, Macek TA, Singh MK, Stanford AD, Domingo SZ.

Innov Clin Neurosci. 2024 Mar 1;21(1-3):52-60. eCollection 2024 Jan-Mar.

PMID: 38495603 

 

Health-related quality of life in patients with triple-class exposed relapsed and refractory multiple myeloma treated with idecabtagene vicleucel or standard regimens: patient-reported outcomes from the phase 3, randomised, open-label KarMMa-3 clinical trial.

Delforge M, Patel K, Eliason L, Dhanda D, Shi L, Guo S, Marshall TS, Arnulf B, Cavo M, Nooka A, Manier S, Callander N, Giralt S, Einsele H, Ailawadhi S, Popa McKiver M, Cook M, Rodríguez-Otero P.

Lancet Haematol. 2024 Mar;11(3):e216-e227. doi: 10.1016/S2352-3026(24)00005-X.

PMID: 38423700 

 

Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design.

Liu C, Wang W, Feng J, Beno B, Raja T, Swidorski J, Manepalli RKVLP, Vetrichelvan M, Rao Jalagam P, Nair SK, Gupta A, Panda M, Ghosh K, Kaushikkumar Shukla J, Sale H, Shah D, Singh Gautam S, Patel D, Mathur A, Ellsworth BA, Cheng D, Regueiro-Ren A.

Bioorg Med Chem. 2024 Mar 1;101:117638. doi: 10.1016/j.bmc.2024.117638. Epub 2024 Feb 11.

PMID: 38394996

 

An Evaluation of Wet Granulation Process Selection for API Prone to Polymorphic Form Conversion in the Presence of Moisture and Heat.

Arce F, Schuman Y, Gawel J, Garmise R, Abebe A, Desai D.

Pharm Res. 2024 Mar;41(3):595-607. doi: 10.1007/s11095-024-03667-5. Epub 2024 Feb 21.

PMID: 38383934

 

Artificial Intelligence to Automate Network Meta-Analyses: Four Case Studies to Evaluate the Potential Application of Large Language Models.

Reason T, Benbow E, Langham J, Gimblett A, Klijn SL, Malcolm B.

Pharmacoecon Open. 2024 Mar;8(2):205-220. doi: 10.1007/s41669-024-00476-9. Epub 2024 Feb 10.

PMID: 38340277 

 

Artificial Intelligence to Automate Health Economic Modelling: A Case Study to Evaluate the Potential Application of Large Language Models.

Reason T, Rawlinson W, Langham J, Gimblett A, Malcolm B, Klijn S.

Pharmacoecon Open. 2024 Mar;8(2):191-203. doi: 10.1007/s41669-024-00477-8. Epub 2024 Feb 10.

PMID: 38340276 

 

Effectiveness and safety of anticoagulants among patients with venous thromboembolism and active cancer who also had prior bleed or prior renal disease.

Cohen AT, Noxon V, Dhamane AD, Shah S, Hines DM, Alfred T, Chaves J, Luo X.

Curr Med Res Opin. 2024 Mar;40(3):545-553. doi: 10.1080/03007995.2024.2313092. Epub 2024 Feb 13.

PMID: 38332714

 

Perspectives on phenotypic screening-Screen Design and Assay Technology Special Interest Group.

Pak C, Simpson KJ, Weston AD, Cvijic ME, Evans K, Napper AD.

SLAS Discov. 2024 Mar;29(2):100146. doi: 10.1016/j.slasd.2024.02.001. Epub 2024 Feb 2.

PMID: 38311110 

 

Evaluation of antisense oligonucleotide therapy targeting Hsd17b13 in a fibrosis mice model.

Ma Y, Cai H, Smith J, Chu CH, Mercer SE, Boehm S, Mcdonald I, Zinker B, Cheng D.

J Lipid Res. 2024 Mar;65(3):100514. doi: 10.1016/j.jlr.2024.100514. Epub 2024 Feb 2.

PMID: 38309418

 

Disparities in burden of disease in patients with rheumatoid arthritis across racial and ethnic groups.

O'Brien J, Park SH, Blachley T, Marchese M, Middaugh N, Wittstock K, Harrold LR.

Clin Rheumatol. 2024 Mar;43(3):921-927. doi: 10.1007/s10067-024-06869-9. Epub 2024 Jan 25.

PMID: 38267768

 

Overcoming NMR line broadening of nitrogen containing compounds: A simple solution.

Ma J, Ye Q, Green RA, Gurak J, Ayers S, Huang Y, Miller SA.

Magn Reson Chem. 2024 Mar;62(3):198-207. doi: 10.1002/mrc.5432. Epub 2024 Jan 23.

PMID: 38258438

 

Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer.

Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, Reis-Filho JS, Ly A, Harms PW, Gupta RR, Vieth M, Hida AI, Kahila M, Kos Z, van Diest PJ, Verbandt S, Thagaard J, Khiroya R, Abduljabbar K, Acosta Haab G, Acs B, Adams S, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Burgues O, Chardas A, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Fernandez-Martín C, Fineberg S, Fox SB, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hart SN, Hartman J, Hewitt S, Horlings HM, Husain Z, Irshad S, Janssen EA, Kataoka TR, Kawaguchi K, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Akturk G, Scott E, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Kharidehal D, Minhas FUAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rajpoot NM, Rapoport B…

 Pathol. 2024 Mar;262(3):271-288. doi: 10.1002/path.6238. Epub 2024 Jan 17.

PMID: 38230434

 

Model-Based Dose Selection of Subcutaneous Nivolumab in Patients with Advanced Solid Tumors.

Zhao Y, Sanghavi K, Roy A, Murthy B, Bello A, Aras U, Vezina H.

Clin Pharmacol Ther. 2024 Mar;115(3):488-497. doi: 10.1002/cpt.3148. Epub 2024 Jan 28.

PMID: 38115195

 

An Industry Perspective on the use of Forced Degradation Studies to Assess Comparability of Biopharmaceuticals.

Campbell JM, Colombo S, Doyle JL, Filoti DI, Hübner G, Magnenat L, Nowinski AK, Pavon JA, Singh SM, Vo LR, Woods JM, Stokes ESE.

J Pharm Sci. 2024 Mar;113(3):505-512. doi: 10.1016/j.xphs.2023.12.011. Epub 2023 Dec 15.

PMID: 38103689

 

Challenging the Norm: A Multidisciplinary Perspective on Intravenous to Subcutaneous Bridging Strategies for Biologics.

Ait-Oudhia S, Wang YM, Dosne AG, Roy A, Jin JY, Shen J, Kagan L, Musuamba FT, Zhang L, Kijima S, Gastonguay MR, Ouellet D.

Clin Pharmacol Ther. 2024 Mar;115(3):412-421. doi: 10.1002/cpt.3133. Epub 2023 Dec 18.

PMID: 38069528 

 

Real-world use and clinical impact of an electronic patient-reported outcome tool in patients with solid tumors treated with immuno-oncology therapy.

Dickson NR, Beauchamp KD, Perry TS, Roush A, Goldschmidt D, Edwards ML, Blakely LJ.

J Patient Rep Outcomes. 2024 Feb 28;8(1):23. doi: 10.1186/s41687-024-00700-4.

PMID: 38416270 

 

Fed-batch performance profiles for mAb production using different intensified N - 1 seed strategies are CHO cell-line dependent.

Tang Y, Xu J, Xu M, Huang Z, Santos J, He Q, Borys M, Khetan A.

Biotechnol Prog. 2024 Feb 28:e3446. doi: 10.1002/btpr.3446. Online ahead of print.

PMID: 38415506

 

Application of fucosylation inhibitors for production of afucosylated antibody.

Xu P, Ou YC, Smith M, Paulson J, Schmidt MA, Kandari L, Parsons R, Khetan A.

Biotechnol Prog. 2024 Feb 28:e3438. doi: 10.1002/btpr.3438. Online ahead of print.

PMID: 38415431

 

Recommendations for using artificial intelligence in clinical flow cytometry.

Ng DP, Simonson PD, Tarnok A, Lucas F, Kern W, Rolf N, Bogdanoski G, Green C, Brinkman RR, Czechowska K.

Cytometry B Clin Cytom. 2024 Feb 26. doi: 10.1002/cyto.b.22166. Online ahead of print.

PMID: 38407537

 

Translating the regulatory landscape of medical devices to create fit-for-purpose artificial intelligence (AI) cytometry solutions.

Bogdanoski G, Lucas F, Kern W, Czechowska K.

Cytometry B Clin Cytom. 2024 Feb 23. doi: 10.1002/cyto.b.22167. Online ahead of print.

PMID: 38396223 

 

Preclinical Characterization of the Anti-Leukemia Activity of the CD33/CD16a/NKG2D Immune-Modulating TriNKET^® CC-96191.

Lunn-Halbert MC, Laszlo GS, Erraiss S, Orr MT, Jessup HK, Thomas HJ, Chan H, Jahromi MA, Lloyd J, Cheung AF, Chang GP, Dichwalkar T, Fallon D, Grinberg A, Rodríguez-Arbolí E, Lim SYT, Kehret AR, Huo J, Cole FM, Scharffenberger SC, Walter RB.

Cancers (Basel). 2024 Feb 22;16(5):877. doi: 10.3390/cancers16050877.

PMID: 38473239 

 

Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies.

Chan H, Trout CV, Mikolon D, Adams P, Guzman R, Mavrommatis K, Abbasian M, Hadjivassiliou H, Dearth L, Fox BA, Sivakumar P, Cho H, Hariharan K.

Cancer Res Commun. 2024 Feb 22;4(2):505-515. doi: 10.1158/2767-9764.CRC-23-0634.

PMID: 38319147 

 

A community challenge to predict clinical outcomes after immune checkpoint blockade in non-small cell lung cancer.

Mason M, Lapuente-Santana Ó, Halkola AS, Wang W, Mall R, Xiao X, Kaufman J, Fu J, Pfeil J, Banerjee J, Chung V, Chang H, Chasalow SD, Lin HY, Chai R, Yu T, Finotello F, Mirtti T, Mäyränpää MI, Bao J, Verschuren EW, Ahmed EI, Ceccarelli M, Miller LD, Monaco G, Hendrickx WRL, Sherif S, Yang L, Tang M, Gu SS, Zhang W, Zhang Y, Zeng Z, Das Sahu A, Liu Y, Yang W, Bedognetti D, Tang J, Eduati F, Laajala TD, Geese WJ, Guinney J, Szustakowski JD, Vincent BG, Carbone DP.

J Transl Med. 2024 Feb 21;22(1):190. doi: 10.1186/s12967-023-04705-3.

PMID: 38383458 

 

Preexisting antibody assays for gene therapy: Considerations on patient selection cutoffs and companion diagnostic requirements.

Braun M, Lange C, Schatz P, Long B, Stanta J, Gorovits B, Tarcsa E, Jawa V, Yang TY, Lembke W, Miller N, McBlane F, Christodoulou L, Yuill D, Milton M.

Mol Ther Methods Clin Dev. 2024 Feb 20;32(1):101217. doi: 10.1016/j.omtm.2024.101217. eCollection 2024 Mar 14.

PMID: 38496304 

 

First-Line Nivolumab Plus Chemotherapy for Advanced Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma: 3-Year Follow-Up of the Phase III CheckMate 649 Trial.

Janjigian YY, Ajani JA, Moehler M, Shen L, Garrido M, Gallardo C, Wyrwicz L, Yamaguchi K, Cleary JM, Elimova E, Karamouzis M, Bruges R, Skoczylas T, Bragagnoli A, Liu T, Tehfe M, Zander T, Kowalyszyn R, Pazo-Cid R, Schenker M, Feeny K, Wang R, Lei M, Chen C, Nathani R, Shitara K.

J Clin Oncol. 2024 Feb 21:JCO2301601. doi: 10.1200/JCO.23.01601. Online ahead of print.

PMID: 38382001

 

Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions.

Ma W, Del Rio CL, Qi L, Prodanovic M, Mijailovich S, Zambataro C, Gong H, Shimkunas R, Gollapudi S, Nag S, Irving TC.

Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2314914121. doi: 10.1073/pnas.2314914121. Epub 2024 Feb 12.

PMID: 38346202

 

Circulating cancer-specific CD8 T cell frequency is associated with response to PD-1 blockade in Merkel cell carcinoma.

Pulliam T, Jani S, Jing L, Ryu H, Jojic A, Shasha C, Zhang J, Kulikauskas R, Church C, Garnett-Benson C, Gooley T, Chapuis A, Paulson K, Smith KN, Pardoll DM, Newell EW, Koelle DM, Topalian SL, Nghiem P.

Cell Rep Med. 2024 Feb 20;5(2):101412. doi: 10.1016/j.xcrm.2024.101412. Epub 2024 Feb 10.

PMID: 38340723 

 

Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Rodent Carcinogenic Potency.

Snodin DJ, Trejo-Martin A, Ponting DJ, Smith GF, Czich A, Cross K, Custer L, Elloway J, Greene N, Kalgutkar AS, Stalford SA, Tennant RE, Vock E, Zalewski A, Ziegler V, Dobo KL.

Chem Res Toxicol. 2024 Feb 19;37(2):181-198. doi: 10.1021/acs.chemrestox.3c00327. Epub 2024 Feb 5.

PMID: 38316048 

Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates.

Subbaiah MAM, Rautio J, Meanwell NA.

Chem Soc Rev. 2024 Feb 19;53(4):2099-2210. doi: 10.1039/d2cs00957a.

PMID: 38226865 

 

Nickel-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers.

Laudadio G, Neigenfind P, Péter Á, Rubel CZ, Emmanuel MA, Oderinde MS, Ewing TE, Palkowitz MD, Sloane JL, Gillman KW, Ridge D, Mandler MD, Bolduc PN, Nicastri MC, Zhang B, Clementson S, Petersen NN, Martín-Gago P, Mykhailiuk P, Engle KM, Baran PS.

Angew Chem Int Ed Engl. 2024 Feb 19;63(8):e202314617. doi: 10.1002/anie.202314617. Epub 2024 Jan 18.

PMID: 38181042

 

Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation.

Hong SH, Divakaran A, Osa A, Huang OW, Wertz IE, Nomura DK.

ACS Chem Biol. 2024 Feb 16;19(2):442-450. doi: 10.1021/acschembio.3c00642. Epub 2024 Feb 2.

PMID: 38305738

 

PD-1 Expression on Intratumoral Regulatory T Cells Is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear-Cell Renal Cell Carcinoma Patients.

Denize T, Jegede OA, Matar S, El Ahmar N, West DJ, Walton E, Bagheri AS, Savla V, Nabil Laimon Y, Gupta S, Vemula SV, Braun DA, Burke KP, Catalano PJ, Freeman GJ, Motzer RJ, Atkins MB, McDermott DF, Sharpe AH, Choueiri TK, Signoretti S.

Clin Cancer Res. 2024 Feb 16;30(4):803-813. doi: 10.1158/1078-0432.CCR-23-2274.

PMID: 38060202

 

Clinical Impact of Switching or Continuation of Apixaban or Rivaroxaban among Patients with Non-Valvular Atrial Fibrillation.

Deitelzweig S, Kang A, Jiang J, Gao C, Luo X, Atreja N, Han S, Cheng D, Loganathan SR, Lip GYH.

J Clin Med. 2024 Feb 14;13(4):1073. doi: 10.3390/jcm13041073.

PMID: 38398386 

 

The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary.

Baker TK, Van Vleet TR, Mahalingaiah PK, Grandhi TSP, Evers R, Ekert J, Gosset JR, Chacko SA, Kopec AK.

Drug Metab Dispos. 2024 Feb 14;52(3):198-209. doi: 10.1124/dmd.123.001510.

PMID: 38123948

 

Reaction-Initiated Single-Molecule Tracking of Mass Transfer in Core-Shell Mesoporous Silica Particles.

Yang M, Mansour N, Huang T, Heffer D, Pei Y, Huang W, Li J, Dong B, Fang N.

Anal Chem. 2024 Feb 13;96(6):2500-2505. doi: 10.1021/acs.analchem.3c04529. Epub 2024 Jan 22.

PMID: 38252963

 

Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism.

Hatakeyama K, Kikushige Y, Ishihara D, Yamamoto S, Kawano G, Tochigi T, Miyamoto T, Sakoda T, Christoforou A, Kunisaki Y, Fukata M, Kato K, Ito T, Handa H, Akashi K.

Blood Adv. 2024 Feb 13;8(3):785-796. doi: 10.1182/bloodadvances.2023010080.

PMID: 38163319 

 

Effect of Mavacamten in Women Compared With Men With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM.

Cresci S, Bach RG, Saberi S, Owens AT, Spertus JA, Hegde SM, Lakdawala NK, Nilles EK, Wojdyla DM, Sehnert AJ, Wang A.

Circulation. 2024 Feb 13;149(7):498-509. doi: 10.1161/CIRCULATIONAHA.123.065600. Epub 2023 Nov 14.

PMID: 37961906

 

Four-year clinical update and treatment switching-adjusted outcomes with first-line nivolumab plus ipilimumab with chemotherapy for metastatic non-small cell lung cancer in the CheckMate 9LA randomized trial.

Carbone DP, Ciuleanu TE, Schenker M, Cobo M, Bordenave S, Juan-Vidal O, Menezes J, Reinmuth N, Richardet E, Cheng Y, Mizutani H, Felip E, Zurawski B, Alexandru A, Paz-Ares L, Lu S, John T, Zhang X, Mahmood J, Hu N, De T, Santi I, Penrod JR, Yuan Y, Lee A, Reck M.

J Immunother Cancer. 2024 Feb 12;12(2):e008189. doi: 10.1136/jitc-2023-008189.

PMID: 38346853 

 

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5.

Dawson JRD, Wadman GM, Zhang P, Tebben A, Carter PH, Gu S, Shroka T, Borrega-Roman L, Salanga CL, Handel TM, Kufareva I.

bioRxiv [Preprint]. 2024 Feb 12:2023.11.15.567150. doi: 10.1101/2023.11.15.567150.

PMID: 38014122 

 

Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease.

Johnson JL, Sargsyan D, Neiman EM, Hart A, Stojmirovic A, Kosoy R, Irizar H, Suárez-Fariñas M, Song WM, Argmann C, Avey S, Shmuel-Galia L, Vierbuchen T, Bongers G, Sun Y, Edelstein L, Perrigoue J, Towne JE, Hall AO, Fitzgerald KA, Hoebe K.

JCI Insight. 2024 Feb 8;9(3):e168988. doi: 10.1172/jci.insight.168988.

PMID: 38329124 

 

Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research.

Caceres-Cortes J, Falk B, Mueller L, Dhar TGM.

J Med Chem. 2024 Feb 8;67(3):1701-1733. doi: 10.1021/acs.jmedchem.3c02389. Epub 2024 Jan 30.

PMID: 38290426 

 

Is atrial fibrillation in HFpEF a distinct phenotype? Insights from multiparametric MRI and circulating biomarkers.

Dattani A, Brady EM, Kanagala P, Stoma S, Parke KS, Marsh AM, Singh A, Arnold JR, Moss AJ, Zhao L, Cvijic ME, Fronheiser M, Du S, Costet P, Schafer P, Carayannopoulos L, Chang CP, Gordon D, Ramirez-Valle F, Jerosch-Herold M, Nelson CP, Squire IB, Ng LL, Gulsin GS, McCann GP.

BMC Cardiovasc Disord. 2024 Feb 7;24(1):94. doi: 10.1186/s12872-024-03734-0.

PMID: 38326736 

Benchtop Nickel Catalysis Invigorated by Electron-Deficient Diene Ligands.

Rubel CZ, He WJ, Wisniewski SR, Engle KM.

Acc Chem Res. 2024 Feb 6;57(3):312-326. doi: 10.1021/acs.accounts.3c00638. Epub 2024 Jan 18.

PMID: 38236260

 

Recommendations for Method Development and Validation of qPCR and dPCR Assays in Support of Cell and Gene Therapy Drug Development.

Hays A, Wissel M, Colletti K, Soon R, Azadeh M, Smith J, Doddareddy R, Chalfant M, Adamowicz W, Ramaswamy SS, Dholakiya SL, Guelman S, Gullick B, Durham J, Rennier K, Nagilla P, Muruganandham A, Diaz M, Tierney C, John K, Valentine J, Lockman T, Liu HY, Moritz B, Ouedraogo JP, Piche MS, Smet M, Murphy J, Koenig K, Zybura A, Vyhlidal C, Mercier J, Jani N, Kubista M, Birch D, Morse K, Johansson O.

AAPS J. 2024 Feb 5;26(1):24. doi: 10.1208/s12248-023-00880-9.

PMID: 38316745

 

Nivolumab monotherapy or combination with ipilimumab with or without cobimetinib in previously treated patients with pancreatic adenocarcinoma (CheckMate 032).

Callahan M, Amin A, Kaye FJ, Morse MA, Taylor MH, Peltola KJ, Sharma P, O'Reilly EM, Meadows Shropshire S, O'Brien S, Tschaika M, Le DT.

J Immunother Cancer. 2024 Feb 5;12(2):e007883. doi: 10.1136/jitc-2023-007883.

PMID: 38316517 

 

Estimated prevalence, incidence and healthcare costs of Sjögren's syndrome in France: a national claims-based study.

Seror R, Chiche L, Beydon M, Desjeux G, Zhuo J, Vannier-Moreau V, Devauchelle-Pensec V.

RMD Open. 2024 Feb 2;10(1):e003591. doi: 10.1136/rmdopen-2023-003591.

PMID: 38307699

 

Delayed treatment initiation of oral anticoagulants among Medicare patients with atrial fibrillation.

Luo X, Chaves J, Dhamane AD, Dai F, Latremouille-Viau D, Wang A.

Am Heart J Plus. 2024 Feb 2;39:100369. doi: 10.1016/j.ahjo.2024.100369. eCollection 2024 Mar.

PMID: 38510996 

 

Identifying general reaction conditions by bandit optimization.

Wang JY, Stevens JM, Kariofillis SK, Tom MJ, Golden DL, Li J, Tabora JE, Parasram M, Shields BJ, Primer DN, Hao B, Del Valle D, DiSomma S, Furman A, Zipp GG, Melnikov S, Paulson J, Doyle AG.

Nature. 2024 Feb;626(8001):1025-1033. doi: 10.1038/s41586-024-07021-y. Epub 2024 Feb 28.

PMID: 38418912

 

Clinical benefit of anti-PD-(L)1 immunotherapies in advanced cancer in France: a population-based estimate from 2014 to 2021.

Grumberg V, Cotté FE, Giroux-Leprieur E, Gaudin AF, Lebbé C, Borget I.

ESMO Open. 2024 Feb;9(2):102240. doi: 10.1016/j.esmoop.2024.102240. Epub 2024 Feb 9.

PMID: 38335904 

 

Magnetic Resonance Imaging-Guided Frameless Stereotactic Injections of the Bilateral Cerebellar Dentate Nuclei in Nonhuman Primates: Technical Note.

Qiu L, Xu E, Chambule S, LaTourette P 2nd, Dyer CD, Wallace CK, Donocoff R, Wilson JM, Lucas TH, Chen HI.

Oper Neurosurg (Hagerstown). 2024 Feb 1. doi: 10.1227/ons.0000000000001050. Online ahead of print.

PMID: 38310346 

Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction.

Azzo JD, Dib MJ, Zagkos L, Zhao L, Wang Z, Chang CP, Ebert C, Salman O, Gan S, Zamani P, Cohen JB, van Empel V, Richards AM, Javaheri A, Mann DL, Rietzschel ER, Schafer PH, Seiffert DA, Gill D, Burgess S, Ramirez-Valle F, Gordon DA, Cappola TP, Chirinos JA.

Circ Heart Fail. 2024 Feb;17(2):e011146. doi: 10.1161/CIRCHEARTFAILURE.123.011146. Epub 2024 Feb 1.

PMID: 38299345

 

LC-MS bioanalysis of protein biomarkers and protein therapeutics in formalin-fixed paraffin-embedded tissue specimens.

G Jagadeeshaprasad M, Zeng J, Zheng N.

Bioanalysis. 2024 Feb;16(4):245-258. doi: 10.4155/bio-2023-0210. Epub 2024 Jan 16.

PMID: 38226835 

 

Author Correction: Enhanced mapping of small-molecule binding sites in cells.

Wozniak JM, Li W, Governa P, Chen LY, Jadhav A, Dongre A, Forli S, Parker CG.

Nat Chem Biol. 2024 Feb;20(2):261. doi: 10.1038/s41589-024-01546-z.

PMID: 38212579 

 

The Clinical Development of Taldefgrobep Alfa: An Anti-Myostatin Adnectin for the Treatment of Duchenne Muscular Dystrophy.

Muntoni F, Byrne BJ, McMillan HJ, Ryan MM, Wong BL, Dukart J, Bansal A, Cosson V, Dreghici R, Guridi M, Rabbia M, Staunton H, Tirucherai GS, Yen K, Yuan X, Wagner KR; Taldefgrobep Alfa Study Group.

Neurol Ther. 2024 Feb;13(1):183-219. doi: 10.1007/s40120-023-00570-w. Epub 2024 Jan 8.

PMID: 38190001 

 

Structure-function relationship study for sulfated protein therapeutics using hydrophobic interaction chromatography and mass spectrometry.

Luo H, Mahon D, Wong P, Madayiputhiya N, Chen Y, Stauffer T, Tao L, Zeng M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Feb 1;1233:123981. doi: 10.1016/j.jchromb.2023.123981. Epub 2023 Dec 22.

PMID: 38184885

Concurrent administration of serotonergic antidepressants and ozanimod in participants with relapsing multiple sclerosis from the open-label extension DAYBREAK trial.

Naismith RT, Cohen JA, Bar-Or A, Comi G, Selmaj KW, Hartung HP, Sheffield JK, Krakovich A, Tatosian D, Cheng CY, Reardon J, Khaychuk V, Riolo JV, Silva D, Cree BA.

Mult Scler. 2024 Feb;30(2):177-183. doi: 10.1177/13524585231216854. Epub 2023 Dec 21.

PMID: 38130041 

 

Neoadjuvant nivolumab plus chemotherapy in resectable non-small-cell lung cancer in Japanese patients from CheckMate 816.

Mitsudomi T, Ito H, Okada M, Sugawara S, Shio Y, Tomii K, Okami J, Sakakura N, Kubota K, Takamochi K, Atagi S, Tsuboi M, Oizumi S, Ikeda N, Ohde Y, Ntambwe I, Mahmood J, Cai J, Tanaka F.

Cancer Sci. 2024 Feb;115(2):540-554. doi: 10.1111/cas.16030. Epub 2023 Dec 14.

PMID: 38098261 

 

Infection outcomes in patients with rheumatoid arthritis treated with abatacept and other disease-modifying antirheumatic drugs: Results from a 10-year international post-marketing study.

Simon TA, Suissa S, Skovron ML, Frisell T, Askling J, Michaud K, Pedro S, Strangfeld A, Meissner Y, Boers M, Hoffman V, Dominique A, Gomez A, Hochberg MC.

Semin Arthritis Rheum. 2024 Feb;64:152313. doi: 10.1016/j.semarthrit.2023.152313. Epub 2023 Nov 10.

PMID: 38044241

 

Treatment patterns of systemic drug use in Japanese patients with plaque psoriasis: A retrospective chart review.

Tada Y, Komine M, Okubo Y, Habiro K, Tsuritani K, Morita A.

J Dermatol. 2024 Feb;51(2):210-222. doi: 10.1111/1346-8138.17038. Epub 2023 Nov 30.

PMID: 38031882

 

CFD-based bioreactor model with proportional-integral-derivative controller functionality for dissolved oxygen and pH.

Oliveira CL, Pace Z, Thomas JA, DeVincentis B, Sirasitthichoke C, Egan S, Lee J.

Biotechnol Bioeng. 2024 Feb;121(2):655-669. doi: 10.1002/bit.28598. Epub 2023 Nov 30.

PMID: 38031493

 

An IQ Consortium Perspective on Best Practices for Bioanalytical and Immunogenicity Assessment Aspects of CAR-T and TCR-T Cellular Therapies Development.

Gokemeijer J, Balasubramanian N, Ogasawara K, Grudzinska-Goebel J, Upreti VV, Mody H, Kasar S, Vepachedu VR, Xu W, Gupta S, Tarcsa E, Dodge R, Herr K, Yang TY, Tourdot S, Jawa V.

Clin Pharmacol Ther. 2024 Feb;115(2):188-200. doi: 10.1002/cpt.3111. Epub 2023 Dec 17.

PMID: 37983584

 

Mechanistic modeling of empty-full separation in recombinant adeno-associated virus production using anion-exchange membrane chromatography.

Gomis-Fons J, Zee B, Hurwit D, Woo J, Moscariello J, Nilsson B.

Biotechnol Bioeng. 2024 Feb;121(2):719-734. doi: 10.1002/bit.28595. Epub 2023 Nov 9.

PMID: 37942560

Publisher Correction: Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial.

Kirkwood JM, Del Vecchio M, Weber J, Hoeller C, Grob JJ, Mohr P, Loquai C, Dutriaux C, Chiarion-Sileni V, Mackiewicz J, Rutkowski P, Arenberger P, Quereux G, Meniawy TM, Ascierto PA, Menzies AM, Durani P, Lobo M, Campigotto F, Gastman B, Long GV.

Nat Med. 2024 Feb;30(2):607. doi: 10.1038/s41591-023-02661-5.

PMID: 37923838 

 

Luspatercept stimulates erythropoiesis, increases iron utilization, and redistributes body iron in transfusion-dependent thalassemia.

Garbowski MW, Ugidos M, Risueño A, Shetty JK, Schwickart M, Hermine O, Porter JB, Thakurta A, Vodala S.

Am J Hematol. 2024 Feb;99(2):182-192. doi: 10.1002/ajh.27102. Epub 2023 Oct 2.

PMID: 37782758

 

Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus.

Aevermann BD, Di Domizio J, Olah P, Saidoune F, Armstrong JM, Bachelez H, Barker J, Haniffa M, Julia V, Juul K, Krishnaswamy JK, Litman T, Parsons I, Sarin KY, Schmuth M, Sierra M, Simpson M, Homey B, Griffiths CEM, Scheuermann RH, Gilliet M.

J Invest Dermatol. 2024 Feb;144(2):252-262.e4. doi: 10.1016/j.jid.2023.06.211. Epub 2023 Aug 19.

PMID: 37598867 

 

Treatment patterns and outcomes with luspatercept in patients with lower-risk myelodysplastic syndromes: A retrospective US cohort analysis.

Mukherjee S, Brown-Bickerstaff C, Falkenstein A, Makinde AY, Bland E, Laney J, Garretson M, Huggar D, McBride A.

Hemasphere. 2024 Jan 30;8(1):e38. doi: 10.1002/hem3.38. eCollection 2024 Jan.

PMID: 38434524 

 

Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1).

Qiao JX, Witmer MR, Lee V, Wang TC, Reid PC, Arioka Y, Farr G, Hill-Drzewi M, Schweizer L, Yamniuk A, Cheng L, Abramczyk B, Corbett M, Calambur D, Szapiel N, Ryseck R, Ponath P, Poss MA, Carter P.

Bioorg Med Chem Lett. 2024 Jan 15;98:129589. doi: 10.1016/j.bmcl.2023.129589. Epub 2023 Dec 13.

PMID: 38097140

 

A Bayesian phase II proof-of-concept design for clinical trials with longitudinal endpoints.

Zhang W, Laird G, Chen J, Yuan Y.

Stat Med. 2024 Jan 15;43(1):173-183. doi: 10.1002/sim.9948. Epub 2023 Nov 8.

PMID: 37937591

 

Efficacy and safety of the muscarinic receptor agonist KarXT (xanomeline-trospium) in schizophrenia (EMERGENT-2) in the USA: results from a randomised, double-blind, placebo-controlled, flexible-dose phase 3 trial.

Kaul I, Sawchak S, Correll CU, Kakar R, Breier A, Zhu H, Miller AC, Paul SM, Brannan SK.

Lancet. 2024 Jan 13;403(10422):160-170. doi: 10.1016/S0140-6736(23)02190-6. Epub 2023 Dec 14.

PMID: 38104575 

 

Electroreductive Synthesis of Nickel(0) Complexes.

Rubel CZ, Cao Y, El-Hayek Ewing T, Laudadio G, Beutner GL, Wisniewski SR, Wu X, Baran PS, Vantourout JC, Engle KM.

Angew Chem Int Ed Engl. 2024 Jan 8;63(2):e202311557. doi: 10.1002/anie.202311557. Epub 2023 Dec 11.

PMID: 37984444

 

Predictive mechanistic modeling of loading and elution in protein A chromatography.

Bhoyar S, Kumar V, Foster M, Xu X, Traylor SJ, Guo J, Lenhoff AM.

J Chromatogr A. 2024 Jan 4;1713:464558. doi: 10.1016/j.chroma.2023.464558. Epub 2023 Dec 4.

PMID: 38096684

 

Development of a Predictive Multiple Reaction Monitoring (MRM) Model for High-Throughput ADME Analyses Using Learning-to-Rank (LTR) Techniques.

Adalia R, Patel S, Paiva A, Kaufman T, Zamora I, Cai X, Sanjuan G, Shou WZ.

J Am Soc Mass Spectrom. 2024 Jan 3;35(1):131-139. doi: 10.1021/jasms.3c00363. Epub 2023 Nov 28.

PMID: 38014625

 

Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies.

Keenan C, Al-Haddawi M, Bienvenu JG, Bradley AE, Brown P, Chen H, Colman K, Elwell M, Gatto N, Goodman D, Jacob B, Lanning L, McKinney L, Muhlbradt E, Perry R, Piaia A, Potenta D, Regan KS, Sefing B, Thibodeau M, Tibbs-Slone E, Woicke J, Zwickl CM.

Toxicol Pathol. 2024 Jan;52(1):13-20. doi: 10.1177/01926233241230553. Epub 2024 Mar 6.

PMID: 38445634

 

Fixed and random effect selections in generalized linear mixed models.

Lu SE, Kim S, Cheng JQ, Lin C, Goyal S, Jabbour SK.

Stat Methods Med Res. 2024 Jan;33(1):3-23. doi: 10.1177/09622802231221201. Epub 2023 Dec 28.

PMID: 38155567

 

United States Value Set for the Functional Assessment of Cancer Therapy-General Eight Dimensions (FACT-8D), a Cancer-Specific Preference-Based Quality of Life Instrument.

King MT, Revicki DA, Norman R, Müller F, Viney RC, Pickard AS, Cella D, Shaw JW; MAUCa Consortium.

Pharmacoecon Open. 2024 Jan;8(1):49-63. doi: 10.1007/s41669-023-00448-5. Epub 2023 Dec 7.

PMID: 38060096 

 

Impact of vasodilators on diuretic response in patients with congestive heart failure: A mechanistic trial of cimlanod (BMS-986231).

Pellicori P, Cleland JGF, Borentain M, Taubel J, Graham FJ, Khan J, Bruzzese D, Kessler P, McMurray JJV, Voors AA, O'Connor CM, Teerlink JR, Felker GM.

Eur J Heart Fail. 2024 Jan;26(1):142-151. doi: 10.1002/ejhf.3077. Epub 2023 Dec 28.

PMID: 37990754 

 

Small molecule. Big biology. Dual phosphatase inhibitor enters the immunotherapy fray.

Wilson NS, Huntington ND.

Immunol Cell Biol. 2024 Jan;102(1):8-11. doi: 10.1111/imcb.12711. Epub 2023 Nov 19.

PMID: 37982351

 

Apixaban versus no anticoagulation for the prevention of venous thromboembolism in children with newly diagnosed acute lymphoblastic leukaemia or lymphoma (PREVAPIX-ALL): a phase 3, open-label, randomised, controlled trial.

O'Brien SH, Rodriguez V, Lew G, Newburger JW, Schultz CL, Orgel E, Derr K, Ranalli MA, Esbenshade AJ, Hochberg J, Kang HJ, Dinikina Y, Mills D, Donovan M, Dyme JL, Favatella NA, Mitchell LG; PREVAPIX-ALL investigators.

Lancet Haematol. 2024 Jan;11(1):e27-e37. doi: 10.1016/S2352-3026(23)00314-9. Epub 2023 Nov 16.

PMID: 37980924 

 

No Recipe for Quantitative Systems Pharmacology Model Validation, but a Balancing Act Between Risk and Cost.

Lemaire V, Hu C, van der Graaf PH, Chang S, Wang W.

Clin Pharmacol Ther. 2024 Jan;115(1):25-28. doi: 10.1002/cpt.3082. Epub 2023 Nov 9.

PMID: 37943003 

 

Real-world outcomes with immuno-oncology therapies in advanced melanoma: final results of the OPTIMIzE registry study.

Kirkwood JM, Kottschade LA, McWilliams RR, Khushalani NI, Jang S, Hallmeyer S, McDermott DF, Tawbi H, Che M, Lee CH, Ritchings C, Le TK, Park B, Ramsey S.

Immunotherapy. 2024 Jan;16(1):29-42. doi: 10.2217/imt-2022-0292. Epub 2023 Nov 8.

PMID: 37937397 

 

Stabilization effects of saccharides in protein formulations: A review of sucrose, trehalose, cyclodextrins and dextrans.

Li J, Wang H, Wang L, Yu D, Zhang X.

Eur J Pharm Sci. 2024 Jan 1;192:106625. doi: 10.1016/j.ejps.2023.106625. Epub 2023 Nov 2.

PMID: 37918545 

 

Considerations for Colorectal Neoplasia Detection in Inflammatory Bowel Disease Clinical Trials.

Yang MM, Usiskin K, Ahmad HA, Ather S, Sreih A, Canavan JB, Farraye FA, Ma C.

Dig Dis. 2024;42(1):12-24. doi: 10.1159/000533395. Epub 2023 Sep 27.

PMID: 37757769 

 

Cost-effectiveness of nivolumab versus surveillance for the adjuvant treatment of patients with urothelial carcinoma who are at high risk of recurrence: a US payer perspective.

Brodtkorb TH, Knight C, Kamgar F, Teitsson S, Kurt M, Patel MY, Poretta T, Mamtani R, Palmer S.

J Med Econ. 2024 Jan-Dec;27(1):543-553. doi: 10.1080/13696998.2024.2329019. Epub 2024 Apr 4.

PMID: 38470512

 

Challenges, considerations, and approaches for developing a cost-effectiveness model for the adjuvant treatment of muscle-invasive urothelial carcinoma: with a spotlight on nivolumab versus placebo.

Teitsson S, Brodtkorb TH, Kurt M, Patel MY, Poretta T, Knight C, Kamgar F, Palmer S.

J Med Econ. 2024 Jan-Dec;27(1):473-481. doi: 10.1080/13696998.2024.2322394. Epub 2024 Mar 25.

PMID: 38385621

 

A Pilot Study to Assess the Suitability of Riboflavin as A Surrogate Marker of Breast Cancer Resistance Protein (BCRP) in Healthy Participants.

Shen H, Huo R, Zhang Y, Wang L, Tong N, Chen W, Paris AJ, Mensah K, Chen M, Xue Y, Li W, Sinz M.

J Pharmacol Exp Ther. 2024 Jan 31:JPET-AR-2023-002015. doi: 10.1124/jpet.123.002015. Online ahead of print.

PMID: 38296646 

 

Model-Informed Clinical Pharmacology Profile of a Novel Fixed-Dose Combination of Nivolumab and Relatlimab in Adult and Adolescent Patients with Solid Tumors.

Zhao Y, Hu Z, Bathena SP, Keidel S, Miller-Moslin K, Statkevich P, Bello A, Roy A, Suryawanshi S.

Clin Cancer Res. 2024 Jan 31. doi: 10.1158/1078-0432.CCR-23-2396. Online ahead of print.

PMID: 38295151

 

Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning.

Román Ivorra JA, Trallero-Araguas E, Lopez Lasanta M, Cebrián L, Lojo L, López-Muñíz B, Fernández-Melon J, Núñez B, Silva-Fernández L, Veiga Cabello R, Ahijado P, De la Morena Barrio I, Costas Torrijo N, Safont B, Ornilla E, Restrepo J, Campo A, Andreu JL, Díez E, López Robles A, Bollo E, Benavent D, Vilanova D, Luján Valdés S, Castellanos-Moreira R.

RMD Open. 2024 Jan 30;10(1):e003353. doi: 10.1136/rmdopen-2023-003353.

PMID: 38296310 

 

Is the price right? Paying for value today to get more value tomorrow.

Ramagopalan SV, Diaz J, Mitchell G, Garrison LP Jr, Kolchinsky P.

BMC Med. 2024 Jan 30;22(1):45. doi: 10.1186/s12916-024-03262-w.

PMID: 38287326 

 

The Relationship Between Health-Related Quality of Life and Overall Survival in Patients With Advanced Renal Cell Carcinoma in CheckMate 214.

Cella D, Choueiri TK, Hamilton M, Blum SI, Ivanescu C, Karu K, Ejzykowicz F, Motzer RJ.

Oncologist. 2024 Jan 27:oyae003. doi: 10.1093/oncolo/oyae003. Online ahead of print.

PMID: 38280218 

 

Payer approval and rejection of oral anticoagulant prescriptions and prescription abandonment patterns among patients with venous thromboembolism.

Hines DM, Doshi R, Anupindi VR, Dai F, Russ C, Stellhorn R, Cheng D, Deeba S, Wang Y, DeKoven M.

J Manag Care Spec Pharm. 2024 Jan 26:1-15. doi: 10.18553/jmcp.2024.23194. Online ahead of print.

PMID: 38277234

 

First-line nivolumab plus ipilimumab with or without chemotherapy for Japanese patients with non-small cell lung cancer: LIGHT-NING study.

Imai H, Kijima T, Azuma K, Kishi K, Saito H, Yamaguchi T, Tanizaki J, Yoneshima Y, Fujita K, Watanabe S, Kitazono S, Fukuhara T, Hataji O, Toi Y, Mizutani H, Hamakawa Y, Maemondo M, Ohsugi T, Suzuki K, Horinouchi H, Ohe Y.

Jpn J Clin Oncol. 2024 Jan 25:hyad195. doi: 10.1093/jjco/hyad195. Online ahead of print.

PMID: 38271158

 

A High-Fidelity Combined ATC-Rxnorm Drug Hierarchy for Large-Scale Observational Research.

Ostropolets A, Talapova P, De Wilde M, Abedtash H, Rijnbeek P, Reich CG.

Stud Health Technol Inform. 2024 Jan 25;310:53-57. doi: 10.3233/SHTI230926.

PMID: 38269764

 

Trends in Neosubstrate Degradation by Cereblon-Based Molecular Glues and the Development of Novel Multiparameter Optimization Scores.

Szewczyk SM, Verma I, Edwards JT, Weiss DR, Chekler ELP.

J Med Chem. 2024 Jan 25;67(2):1327-1335. doi: 10.1021/acs.jmedchem.3c01872. Epub 2024 Jan 3.

PMID: 38170610

 

Nivolumab Plus 5-Azacitidine in Pediatric Relapsed/Refractory Acute Myeloid Leukemia (AML): Phase I/II Trial Results from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium.

Verma A, Chi YY, Malvar J, Lamble A, Chaudhury S, Agarwal A, Li HT, Liang G, Leong R, Brown PA, Kaplan J, Schafer ES, Slone T, Pauly M, Chang BH, Stieglitz E, Wayne AS, Hijiya N, Bhojwani D.

Cancers (Basel). 2024 Jan 24;16(3):496. doi: 10.3390/cancers16030496.

PMID: 38339248 

 

Recent Developments in Tyrosine Kinase Inhibitor-based Nanotherapeutics for EGFR-resistant Non-small Cell Lung Cancer.

Kole E, Jadhav K, Singh R, Mandpe S, Abhang A, Verma RK, Naik J.

Curr Drug Deliv. 2024 Jan 24. doi: 10.2174/0115672018278617231207051907. Online ahead of print.

PMID: 38275043

 

Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in Japanese patients with moderate to severe plaque, erythrodermic, or generalized pustular psoriasis: Efficacy and safety results from an open-label, phase 3 trial.

Imafuku S, Okubo Y, Tada Y, Ohtsuki M, Colston E, Napoli A, Shao Y, Banerjee S, Morita A.

J Dermatol. 2024 Jan 24. doi: 10.1111/1346-8138.17074. Online ahead of print.

PMID: 38268101

 

Pregnancy Outcomes in the Ozanimod Clinical Development Program in Patients With Ulcerative Colitis, Crohn's Disease, and Relapsing Multiple Sclerosis.

Dubinsky MC, Charles L, Selmaj KW, Comi G, Krakovich A, Rosen M, van der Woude CJ, Mahadevan U.

Inflamm Bowel Dis. 2024 Jan 24:izae011. doi: 10.1093/ibd/izae011. Online ahead of print.

PMID: 38267826

 

Determining the Impact of Roller Compaction Processing Conditions on Granulate and API Properties: Impact of Formulation API Load.

Clarke J, Gamble JF, Jones JW, Tobyn M, Ingram A, Greenwood R.

AAPS PharmSciTech. 2024 Jan 24;25(1):24. doi: 10.1208/s12249-024-02744-7.

PMID: 38267745

 

Membrane transporters in drug development and as determinants of precision medicine.

Galetin A, Brouwer KLR, Tweedie D, Yoshida K, Sjöstedt N, Aleksunes L, Chu X, Evers R, Hafey MJ, Lai Y, Matsson P, Riselli A, Shen H, Sparreboom A, Varma MVS, Yang J, Yang X, Yee SW, Zamek-Gliszczynski MJ, Zhang L, Giacomini KM.

Nat Rev Drug Discov. 2024 Jan 24. doi: 10.1038/s41573-023-00877-1. Online ahead of print.

PMID: 38267543

 

Administering selected subscales of patient-reported outcome questionnaires to reduce patient burden and increase relevance: a position statement on a modular approach.

Serrano D, Cella D, Husereau D, King-Kallimanis B, Mendoza T, Salmonson T, Stone A, Zaleta A, Dhanda D, Moshyk A, Liu F, Shields AL, Taylor F, Spite S, Shaw JW, Braverman J.

Qual Life Res. 2024 Jan 24. doi: 10.1007/s11136-023-03587-8. Online ahead of print.

PMID: 38265747

 

ACCORD (ACcurate COnsensus Reporting Document): A reporting guideline for consensus methods in biomedicine developed via a modified Delphi.

Gattrell WT, Logullo P, van Zuuren EJ, Price A, Hughes EL, Blazey P, Winchester CC, Tovey D, Goldman K, Hungin AP, Harrison N.

PLoS Med. 2024 Jan 23;21(1):e1004326. doi: 10.1371/journal.pmed.1004326. eCollection 2024 Jan.

PMID: 38261576 

 

Nivolumab Plus Chemotherapy in Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small-Cell Lung Cancer After Disease Progression on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Final Results of CheckMate 722.

Mok T, Nakagawa K, Park K, Ohe Y, Girard N, Kim HR, Wu YL, Gainor J, Lee SH, Chiu CH, Kim SW, Yang CT, Wu CL, Wu L, Lin MC, Samol J, Ichikado K, Wang M, Zhang X, Sylvester J, Li S, Forslund A, Yang JC.

J Clin Oncol. 2024 Jan 22:JCO2301017. doi: 10.1200/JCO.23.01017. Online ahead of print.

PMID: 38252907

 

Evaluating Treatment Choice in Patients with Moderate to Severe Psoriasis in the United States: Results from a US Patient Survey.

Armstrong AW, Jayade S, Rege S, Joshi N, Patel V, Kalirai S, Wolin D, Boyle K, Patel D, Seigel L.

Dermatol Ther (Heidelb). 2024 Jan 22. doi: 10.1007/s13555-023-01089-6. Online ahead of print.

PMID: 38252376

 

Comparative effectiveness of abatacept versus TNF inhibitors in rheumatoid arthritis patients who are ACPA and shared epitope positive.

Harrold LR, Wittstock K, Kelly S, Han X, Zhuo J, Schrader A, Middaugh N, Moore PC, Khaychuk V.

Adv Rheumatol. 2024 Jan 19;64(1):10. doi: 10.1186/s42358-024-00352-4.

PMID: 38243281

 

Real-world safety of first-line immuno-oncology combination therapies for advanced non-small-cell lung cancer.

Betts KA, Gao S, Ray S, Schoenfeld AJ.

Future Oncol. 2024 Jan 19. doi: 10.2217/fon-2023-0612. Online ahead of print.

PMID: 38240151 

 

Safety and effectiveness of abatacept in juvenile idiopathic arthritis: results from the PRINTO/PRCSG registry.

Lovell DJ, Tzaribachev N, Henrickson M, Simonini G, Griffin TA, Alexeeva E, Bohnsack JF, Zeft A, Horneff G, Vehe RK, Staņēviča V, Tarvin S, Trachana M, Del Río AQ, Huber AM, Kietz D, Orbán I, Dare J, Foeldvari I, Quartier P, Dominique A, Simon TA, Martini A, Brunner HI, Ruperto N.

Rheumatology (Oxford). 2024 Jan 18:keae025. doi: 10.1093/rheumatology/keae025. Online ahead of print.

PMID: 38243722

 

Treatment patterns and costs among US patients with diffuse large B-cell lymphoma not treated with 2L stem cell transplantation.

Acheampong T, Gu T, Le TK, Keating SJ.

Future Oncol. 2024 Jan 17. doi: 10.2217/fon-2023-0385. Online ahead of print.

PMID: 38230990 

 

Deucravacitinib in plaque psoriasis: 2-year safety and efficacy results from the phase 3 poetyk trials.

Lebwohl M, Warren RB, Sofen H, Imafuku S, Paul C, Szepietowski JC, Spelman L, Passeron T, Vritzali E, Napoli A, Kisa RM, Buck A, Banerjee S, Thaçi D, Blauvelt A.

Br J Dermatol. 2024 Jan 16:ljae014. doi: 10.1093/bjd/ljae014. Online ahead of print.c

PMID: 38226713

 

Circulating Biomarker Analyses in a Longitudinal Cohort of Patients with IPF.

Ebert C, Walsh AM, Sereda L, Wilson C, Schafer PH, Fischer A, Zhao L, Ramirez-Valle F, Gordon D, Schnapp LM.

Am J Physiol Lung Cell Mol Physiol. 2024 Jan 16. doi: 10.1152/ajplung.00222.2023. Online ahead of print.

PMID: 38226605

 

A Future European Scientific Dialogue Regulatory Framework: Connecting the Dots.

Hey C, Hunter A, Muller M, Roux NL, Bennett S, Nowok K, Oliveira L.

Clin Ther. 2024 Jan 15:S0149-2918(23)00494-0. doi: 10.1016/j.clinthera.2023.12.006. Online ahead of print.

PMID: 38228459 

 

Randomised, siteless study to compare systematic atrial fibrillation screening using enrichment by a risk prediction model with standard care in a Swedish population aged ≥ 65 years: CONSIDERING-AF study design.

Etminani F, Sandgren E, Holm J, Magnusson P, Modica A, Moberg K, Davidsson T, Stalpe L, Kiflemariam S, Younan N, Parikh P, Wadhwa M, Sundin A, Engdahl J.

BMJ Open. 2024 Jan 12;14(1):e080639. doi: 10.1136/bmjopen-2023-080639.

PMID: 38216189

 

Drug Utilization Studies in Pregnant Women for Newly Licensed Medicinal Products: A Contribution from IMI ConcePTION.

Lopez-Leon S, Geldhof A, Scotto J, Wurst K, Sabidó M, Mo J, Molgaard-Nielsen D, Bergman JEH, Phi XA, Jordan S.

J Pregnancy. 2024 Jan 11;2024:8862801. doi: 10.1155/2024/8862801. eCollection 2024.

PMID: 38250012 

 

Miniaturized CAR knocked onto CD3ε extends TCR function with CAR specificity under control of endogenous TCR signaling cascade.

Manske K, Dreßler L, Fräßle SP, Effenberger M, Tschulik C, Cletiu V, Benke E, Wagner M, Schober K, Müller TR, Stemberger C, Germeroth L, Busch DH, Poltorak MP.

J Immunol Methods. 2024 Jan 11;526:113617. doi: 10.1016/j.jim.2024.113617. Online ahead of print.

PMID: 38215900 

 

Repotrectinib in ROS1 Fusion-Positive Non-Small-Cell Lung Cancer.

Drilon A, Camidge DR, Lin JJ, Kim SW, Solomon BJ, Dziadziuszko R, Besse B, Goto K, de Langen AJ, Wolf J, Lee KH, Popat S, Springfeld C, Nagasaka M, Felip E, Yang N, Velcheti V, Lu S, Kao S, Dooms C, Krebs MG, Yao W, Beg MS, Hu X, Moro-Sibilot D, Cheema P, Stopatschinskaja S, Mehta M, Trone D, Graber A, Sims G, Yuan Y, Cho BC; TRIDENT-1 Investigators.

N Engl J Med. 2024 Jan 11;390(2):118-131. doi: 10.1056/NEJMoa2302299.

PMID: 38197815 

 

Abatacept and non-melanoma skin cancer in patients with rheumatoid arthritis: a comprehensive evaluation of randomised controlled trials and observational studies.

Simon TA, Dong L, Suissa S, Michaud K, Pedro S, Hochberg M, Boers M, Askling J, Frisell T, Strangfeld A, Meissner Y, Khaychuk V, Dominique A, Maldonado MA.

Ann Rheum Dis. 2024 Jan 11;83(2):177-183. doi: 10.1136/ard-2023-224356.

PMID: 37932010 

 

A Systematic Literature Review of Health-Related Quality of Life Outcomes and Associated Utility Values in Relapsed and/or Refractory Large B Cell Lymphoma.

Liu FF, Bartlett M, Craigie S.

Pharmacoecon Open. 2024 Jan 10. doi: 10.1007/s41669-023-00464-5. Online ahead of print.

PMID: 38198111 

 

Effectiveness and safety of anticoagulants among patients with venous thromboembolism and common cancers or cancers with high venous thromboembolism risk.

Cohen AT, Noxon V, Dhamane AD, Shah S, Hines DM, Alfred T, Luo X.

Future Oncol. 2024 Jan 10. doi: 10.2217/fon-2022-1254. Online ahead of print.

PMID: 38197229 

 

Interval estimation of relative risks for combined unilateral and bilateral correlated data.

Wang K, Ma CX.

J Biopharm Stat. 2024 Jan 9:1-24. doi: 10.1080/10543406.2023.2297789. Online ahead of print.

PMID: 38196244

 

Novel Independent Trans- and Cis-Genetic Variants Associated with CYP2D6 Expression and Activity in Human Livers.

Smith D, He B, Shi J, Zhu HJ, Wang X.

Drug Metab Dispos. 2024 Jan 9;52(2):143-152. doi: 10.1124/dmd.123.001548.

PMID: 38050015

 

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.

He L, Zhang MY, Cox M, Zhang Q, Donnell AF, Zhang Y, Tarby C, Gill P, Subbaiah MAM, Ramar T, Reddy M, Puttapaka V, Li YX, Sivaprakasam P, Critton D, Mulligan D, Xie C, Ramakrishnan R, Nagar J, Dudhgaonkar S, Murtaza A, Oderinde MS, Schieven GL, Mathur A, Gavai AV, Vite G, Gangwar S, Poudel YB.

ACS Med Chem Lett. 2024 Jan 9;15(2):189-196. doi: 10.1021/acsmedchemlett.3c00456. eCollection 2024 Feb 8.

PMID: 38352849

 

ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma.

Neri P, Barwick BG, Jung D, Patton JC, Maity R, Tagoug I, Stein CK, Tilmont R, Leblay N, Ahn S, Lee H, Welsh SJ, Riggs DL, Stong N, Flynt E, Thakurta A, Keats JJ, Lonial S, Bergsagel PL, Boise LH, Bahlis NJ.

Blood Cancer Discov. 2024 Jan 8;5(1):56-73. doi: 10.1158/2643-3230.BCD-23-0061.

PMID: 37934799 

 

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.

Poudel YB, He L, Cox M, Zhang Q, Johnson WL, Cong Q, Cheng H, Chowdari NS, Tarby C, Donnell AF, Broekema M, O'Malley DP, Zhang Y, A M Subbaiah M, Kumar BV, Subramani L, Wang B, Li YX, Sivaprakasam P, Critton D, Mulligan D, Sandhu B, Xie C, Ramakrishnan R, Nagar J, Dudhgaonkar S, Oderinde MS, Murtaza A, Schieven GL, Mathur A, Gavai AV, Vite G, Gangwar S.

ACS Med Chem Lett. 2024 Jan 8;15(2):181-188. doi: 10.1021/acsmedchemlett.3c00455. eCollection 2024 Feb 8.

PMID: 38352830

 

Author Correction: Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial.

Kirkwood JM, Del Vecchio M, Weber J, Hoeller C, Grob JJ, Mohr P, Loquai C, Dutriaux C, Chiarion-Sileni V, Mackiewicz J, Rutkowski P, Arenberger P, Quereux G, Meniawy TM, Ascierto PA, Menzies AM, Durani P, Lobo M, Campigotto F, Gastman B, Long GV.

Nat Med. 2024 Jan 4. doi: 10.1038/s41591-023-02775-w. Online ahead of print.

PMID: 38177857

 

Adaptive modeling optimized by the data fusion strategy: Real-time dying cell percentage prediction using capacitance spectroscopy.

Wu S, Ketcham SA, Corredor C, Both D, Zhao Y, Drennen JK, Anderson CA.

Biotechnol Prog. 2024 Jan 4:e3424. doi: 10.1002/btpr.3424. Online ahead of print.

PMID: 38178645

 

Corrigendum to "Disease-free Survival Analysis for Patients with High-risk Muscle-invasive Urothelial Carcinoma from the Randomized CheckMate 274 Trial by PD-L1 Combined Positive Score and Tumor Cell Score" [Eur. Urol. 83(5) (2024) 432-440].

Galsky MD, Bajorin DF, Witjes JA, Gschwend JE, Tomita Y, Nasroulah F, Li J, Collette S, Valderrama BP, Grimm MO, Appleman L, Gravis G, Necchi A, Ye D, Stenner F, Wind-Rotolo M, Zhang J, Ünsal-Kaçmaz K.

Eur Urol. 2024 Jan 3:S0302-2838(23)03306-7. doi: 10.1016/j.eururo.2023.12.013. Online ahead of print.

PMID: 38176992 

 

Enhanced mapping of small-molecule binding sites in cells.

Wozniak JM, Li W, Governa P, Chen LY, Jadhav A, Dongre A, Forli S, Parker CG.

Nat Chem Biol. 2024 Jan 2. doi: 10.1038/s41589-023-01514-z. Online ahead of print.

PMID: 38167919

 

Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers.

Pollock KG, Dickerson C, Kainth M, Lawton S, Hurst M, Sugrue DM, Arden C, Davies DW, Martin AC, Sandler B, Gordon J, Farooqui U, Clifton D, Mallen C, Rogers J, Hill NR, Camm AJ, Cohen AT.

BMC Prim Care. 2024 Jan 2;25(1):7. doi: 10.1186/s12875-023-02246-8.

PMID: 38166641 

 

MRCK as a Potential Target for Claudin-Low Subtype of Breast Cancer.

Yamaguchi H, Chang LC, Chang OS, Chen YF, Hsiao YC, Wu CS, Hung MC.

Int J Biol Sci. 2024 Jan 1;20(1):1-14. doi: 10.7150/ijbs.88285. eCollection 2024.

PMID: 38164185 

 

Acute myeloid leukemia: Current understanding and management.

Becker M, Farina KA, Mascarenhas J.J

AAPA. 2024 Jan 1;37(1):34-39. doi: 10.1097/01.JAA.0000995680.52352.b5.

PMID: 38128137

 

Corrigendum to "Real-world clinical outcomes with enasidenib in relapsed or refractory acute myeloid leukemia" [Leuk. Res. (2022) 106946].

Klink AJ, Gajra A, Knoth RL, Marshall L, Hou Y, McBride A, Copher R.

Leuk Res. 2024 Jan;136:107430. doi: 10.1016/j.leukres.2023.107430. Epub 2024 Jan 9.

PMID: 38199929 

 

Mavacamten Treatment for Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results From the MAVA-LTE Study, EXPLORER-LTE Cohort.

Rader F, Oręziak A, Choudhury L, Saberi S, Fermin D, Wheeler MT, Abraham TP, Garcia-Pavia P, Zwas DR, Masri A, Owens A, Hegde SM, Seidler T, Fox S, Balaratnam G, Sehnert AJ, Olivotto I.

JACC Heart Fail. 2024 Jan;12(1):164-177. doi: 10.1016/j.jchf.2023.09.028.

PMID: 38176782 

 

Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial.

Sharma M, Molina CA, Toyoda K, Bereczki D, Bangdiwala SI, Kasner SE, Lutsep HL, Tsivgoulis G, Ntaios G, Czlonkowska A, Shuaib A, Amarenco P, Endres M, Yoon BW, Tanne D, Toni D, Yperzeele L, von Weitzel-Mudersbach P, Sampaio Silva G, Avezum A, Dawson J, Strbian D, Tatlisumak T, Eckstein J, Ameriso SF, Weber JR, Sandset EC, Goar Pogosova N, Lavados PM, Arauz A, Gailani D, Diener HC, Bernstein RA, Cordonnier C, Kahl A, Abelian G, Donovan M, Pachai C, Li D, Hankey GJ.

Lancet Neurol. 2024 Jan;23(1):46-59. doi: 10.1016/S1474-4422(23)00403-9.

PMID: 38101902 

 

Clinical characteristics, treatment patterns, and outcomes among African American and White patients with multiple myeloma in the United States.

Saunders A, Slaff S, Subbiah K, Gu T, Ang KK, Quan MA, Rosenberg AS.

Leuk Lymphoma. 2024 Jan;65(1):109-117. doi: 10.1080/10428194.2023.2273746. Epub 2024 Jan 10.

PMID: 37917858

 

CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin's lymphoma.

Zhu D, Hadjivassiliou H, Jennings C, Mikolon D, Ammirante M, Acharya S, Lloyd J, Abbasian M, Narla RK, Piccotti JR, Stamp K, Cho H, Hariharan K.

MAbs. 2024 Jan-Dec;16(1):2310248. doi: 10.1080/19420862.2024.2310248. Epub 2024 Feb 13.

PMID: 38349008

Evidence of trospium's ability to mitigate cholinergic adverse events related to xanomeline: phase 1 study results.

Breier A, Brannan SK, Paul SM, Miller AC.

Psychopharmacology (Berl). 2023 May;240(5):1191-1198. doi: 10.1007/s00213-023-06362-2. Epub 2023 Apr 10.

PMID: 37036495 

 

Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders.

Baglaenko Y, Wagner C, Bhoj VG, Brodin P, Gershwin ME, Graham D, Invernizzi P, Kidd KK, Korsunsky I, Levy M, Mammen AL, Nizet V, Ramirez-Valle F, Stites EC, Williams MS, Wilson M, Rose NR, Ladd V, Sirota M.

Camb Prism Precis Med. 2023 May 11;1:e25. doi: 10.1017/pcm.2023.14. eCollection 2023.

PMID: 38550937

 

Towards in vitro models for reducing or replacing the use of animals in drug testing.

Stresser DM, Kopec AK, Hewitt P, Hardwick RN, Van Vleet TR, Mahalingaiah PKS, O'Connell D, Jenkins GJ, David R, Graham J, Lee D, Ekert J, Fullerton A, Villenave R, Bajaj P, Gosset JR, Ralston SL, Guha M, Amador-Arjona A, Khan K, Agarwal S, Hasselgren C, Wang X, Adams K, Kaushik G, Raczynski A, Homan KA.

Nat Biomed Eng. 2023 Dec 27. doi: 10.1038/s41551-023-01154-7. Online ahead of print.

PMID: 38151640 

 

Nivolumab in sorafenib-naive and sorafenib-experienced patients with advanced hepatocellular carcinoma: 5-year follow-up from CheckMate 040.

El-Khoueiry AB, Trojan J, Meyer T, Yau T, Melero I, Kudo M, Hsu C, Kim TY, Choo SP, Kang YK, Yeo W, Chopra A, Soleymani S, Yao J, Neely J, Tschaika M, Welling TH, Sangro B.

Ann Oncol. 2023 Dec 25:S0923-7534(23)05115-3. doi: 10.1016/j.annonc.2023.12.008. Online ahead of print.

PMID: 38151184 

 

Conformational states of the microtubule nucleator, the γ-tubulin ring complex.

Romer B, Travis SM, Mahon BP, McManus CT, Jeffrey PD, Coudray N, Raghu R, Rale MJ, Zhong ED, Bhabha G, Petry S.

bioRxiv. 2023 Dec 21:2023.12.19.572162. doi: 10.1101/2023.12.19.572162. Preprint.

PMID: 38187763 

 

Unanchored Population-Adjusted Indirect Comparison Methods for Time-to-Event Outcomes Using Inverse Odds Weighting, Regression Adjustment, and Doubly Robust Methods With Either Individual Patient or Aggregate Data.

Park JE, Campbell H, Towle K, Yuan Y, Jansen JP, Phillippo D, Cope S.

Value Health. 2023 Dec 20:S1098-3015(23)06235-6. doi: 10.1016/j.jval.2023.11.011. Online ahead of print.

PMID: 38135212 

 

Development, Characterization, and Radiation Dosimetry Studies of ¹⁸F-BMS-986229, a ¹⁸F-Labeled PD-L1 Macrocyclic Peptide PET Tracer.

Kim J, Donnelly DJ, Tran T, Pena A, Shorts AO, Petrone TV, Zhang Y, Boy KM, Scola PM, Tenney DJ, Poss MA, Soars MG, Bonacorsi SJ Jr, Cole EL, Grootendorst DJ, Chow PL, Meanwell NA, Du S.

Mol Imaging Biol. 2023 Dec 20. doi: 10.1007/s11307-023-01889-4. Online ahead of print.

PMID: 38123744

 

Adult stem cell activity in naked mole rats for long-term tissue maintenance.

Montazid S, Bandyopadhyay S, Hart DW, Gao N, Johnson B, Thrumurthy SG, Penn DJ, Wernisch B, Bansal M, Altrock PM, Rost F, Gazinska P, Ziolkowski P, Hayee B, Liu Y, Han J, Tessitore A, Koth J, Bodmer WF, East JE, Bennett NC, Tomlinson I, Irshad S.

Nat Commun. 2023 Dec 20;14(1):8484. doi: 10.1038/s41467-023-44138-6.

PMID: 38123565 

 

Meaningful Change Thresholds for the Psoriasis Symptoms and Signs Diary: A Secondary Analysis of a Randomized Clinical Trial.

Papp KA, Gordon K, Strober B, Zhuo J, Becker B, Zhong Y, Beaumont JL, Pham TP, Kisa R, Napoli AA, Banerjee S, Armstrong AW.

JAMA Dermatol. 2023 Dec 20:e235058. doi: 10.1001/jamadermatol.2023.5058. Online ahead of print.

PMID: 38117487 

 

Nivolumab and ipilimumab population pharmacokinetics in support of pediatric dose recommendations-Going beyond the body-size effect.

Hu Z, Liu S, Zhao Y, Du S, Hamuro L, Shen J, Roy A, Zhu L.

CPT Pharmacometrics Syst Pharmacol. 2023 Dec 19. doi: 10.1002/psp4.13098. Online ahead of print.

PMID: 38115545 

 

Deucravacitinib, a selective, allosteric tyrosine kinase 2 inhibitor, in scalp psoriasis: A subset analysis of two phase 3 randomized trials in plaque psoriasis.

Blauvelt A, Rich P, Sofen H, Strober B, Merola JF, Lebwohl M, Morita A, Szepietowski JC, Lambert J, Hippeli L, Colston E, Balagula E, Banerjee S, Thaçi D.

J Am Acad Dermatol. 2023 Dec 18:S0190-9622(23)03374-1. doi: 10.1016/j.jaad.2023.11.060. Online ahead of print.

PMID: 38122848 

 

Immune-related colitis is associated with fecal microbial dysbiosis and can be mitigated by fecal microbiota transplantation.

Elkrief A, Waters NR, Smith N, Dai A, Slingerland J, Aleynick N, Febles B, Gogia P, Socci ND, Lumish M, Giardina PA, Chaft JE, Eng J, Motzer RJ, Mendelsohn RB, Markey KA, Zhuang M, Li Y, Yang Z, Hollmann TJ, Rudin CM, van den Brink MRM, Shia J, DeWolf S, Schoenfeld AJ, Hellmann MD, Babady NE, Faleck DM, Peled JU.

Cancer Immunol Res. 2023 Dec 18. doi: 10.1158/2326-6066.CIR-23-0498. Online ahead of print.

PMID: 38108398

 

Phenoxythiazoline (FTz)-Cobalt(II) Precatalysts Enable C(sp² )-C(sp³ ) Bond-Formation for Key Intermediates in the Synthesis of Toll-like Receptor 7/8 Antagonists.

Mills LR, Di Mare F, Gygi D, Lee H, Simmons EM, Kim J, Wisniewski SR, Chirik PJ.

Angew Chem Int Ed Engl. 2023 Dec 18;62(51):e202313848. doi: 10.1002/anie.202313848. Epub 2023 Nov 20.

PMID: 37917119

 

The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity.

Kalkreuter E, Kautsar SA, Yang D, Teijaro CN, Bader CD, Fluegel LL, Davis CM, Simpson JR, Steele AD, Gui C, Meng S, Li G, Viehrig K, Ye F, Su P, Kiefer AF, Lauterbach L, Nichols A, Cepeda AJ, Yan W, Fan B, Jiang Y, Adhikari A, Zheng CJ, Shen B.

bioRxiv. 2023 Dec 15:2023.12.14.571759. doi: 10.1101/2023.12.14.571759. Preprint.

PMID: 38168313 

 

Free Energy Perturbation Approach for Accurate Crystalline Aqueous Solubility Predictions.

Hong RS, Rojas AV, Bhardwaj RM, Wang L, Mattei A, Abraham NS, Cusack KP, Pierce MO, Mondal S, Mehio N, Bordawekar S, Kym PR, Abel R, Sheikh AY.

J Med Chem. 2023 Dec 14;66(23):15883-15893. doi: 10.1021/acs.jmedchem.3c01339. Epub 2023 Nov 28.

PMID: 38016916

 

Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2).

Chen Y, Whitefield B, Nevius E, Hill M, DelRosario J, Sinitsyna N, Shanmugasundaram V, Mukherjee D, Shi L, Mayne CG, Rousseau AM, Bernard SM, Buenviaje J, Khambatta G, El Samin M, Wallace M, Nie Z, Sivakumar P, Hamann LG, McDonnell DP, D'Agostino LA.

J Med Chem. 2023 Dec 14;66(23):15750-15760. doi: 10.1021/acs.jmedchem.3c01137. Epub 2023 Nov 27.

PMID: 38009718

 

Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation.

Norris S, Ba X, Rhodes J, Huang D, Khambatta G, Buenviaje J, Nayak S, Meiring J, Reiss S, Xu S, Shi L, Whitefield B, Alexander M, Horn EJ, Correa M, Tehrani L, Hansen JD, Papa P, Mortensen DS.

J Med Chem. 2023 Dec 14;66(23):16388-16409. doi: 10.1021/acs.jmedchem.3c01848. Epub 2023 Nov 22.

PMID: 37991844

 

A Review of the Use of EQ-5D for Clinical Outcome Assessment in Health Technology Assessment, Regulatory Claims, and Published Literature.

Shaw C, Longworth L, Bennett B, McEntee-Richardson L, Shaw JW.

Patient. 2023 Dec 12. doi: 10.1007/s40271-023-00662-7. Online ahead of print.

PMID: 38085457 

 

Apixaban for Prevention of Thromboembolism in Pediatric Heart Disease.

Payne RM, Burns KM, Glatz AC, Male C, Donti A, Brandão LR, Balling G, VanderPluym CJ, Bu'Lock F, Kochilas LK, Stiller B, Cnota JF 2nd, Rahkonen O, Khan A, Adorisio R, Stoica S, May L, Burns JC, Saraiva JFK, McHugh KE, Kim JS, Rubio A, Chía-Vazquez NG, Meador MR, Dyme JL, Reedy AM, Ajavon-Hartmann T, Jarugula P, Carlson-Taneja LE, Mills D, Wheaton O, Monagle P.

J Am Coll Cardiol. 2023 Dec 12;82(24):2296-2309. doi: 10.1016/j.jacc.2023.10.010.

PMID: 38057072 

 

Titanium Dioxide (E171 Grade) and the Search For Replacement Opacifiers and Colorants: Supplier Readiness Survey, Case Studies and Regulatory Perspective.

Hancock B, Harris D, Kaye J, Meehan L, Melnick J, Tobyn M, Gibbard B, Grou J, Guarino CT, Halota M, Howard M, Marshall CL, Varghese S, Khaled H, Butterworth P.

J Pharm Sci. 2023 Dec 11:S0022-3549(23)00515-4. doi: 10.1016/j.xphs.2023.12.006. Online ahead of print.

PMID: 38092288

 

Lisocabtagene Maraleucel in Relapsed/Refractory Mantle Cell Lymphoma: Primary Analysis of the Mantle Cell Lymphoma Cohort From TRANSCEND NHL 001, a Phase I Multicenter Seamless Design Study.

Wang M, Siddiqi T, Gordon LI, Kamdar M, Lunning M, Hirayama AV, Abramson JS, Arnason J, Ghosh N, Mehta A, Andreadis C, Solomon SR, Kostic A, Dehner C, Espinola R, Peng L, Ogasawara K, Chattin A, Eliason L, Palomba ML.

J Clin Oncol. 2023 Dec 10:JCO2302214. doi: 10.1200/JCO.23.02214. Online ahead of print.

PMID: 38072625

 

Meeting Report on the 3rd Chinese American Society for Mass Spectrometry Conference-Advancing Biological and Pharmaceutical Mass Spectrometry.

Chen H, Fu Y, Han M, Han X, Hao L, Huan T, Huang L, Huang M, Ji Q, Jiang T, Jiang Y, Li L, Li L, Liang X, Lih M, Lin Y, Liu X, Liu T, Liu Y, Ma S, Peng J, Qi YA, Qu J, Shou W, Sun L, Wang M, Wang S, Wu R, Wu S, Yan X, Yang J, Yang W, Yang Z, Yu Y, Zhang H, Zhang H, Zhao S, Zhu J, Zhu Y, Wang Y, Weng N.

Biomed Chromatogr. 2023 Dec 10:e5795. doi: 10.1002/bmc.5795. Online ahead of print.

PMID: 38071756

 

Inhibiting stromal Class I HDACs curbs pancreatic cancer progression.

Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM.

Nat Commun. 2023 Dec 6;14(1):7791. doi: 10.1038/s41467-023-42178-6.

PMID: 38057326 

 

The discovery and evaluation of [¹⁸F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement.

Donnelly DJ, Kim J, Tran T, Scola PM, Tenney D, Pena A, Petrone T, Zhang Y, Boy KM, Poss MA, Cole EL, Soars MG, Johnson BM, Cohen D, Batalla D, Chow PL, Shorts AO, Du S, Meanwell NA, Bonacorsi SJ Jr.

Eur J Nucl Med Mol Imaging. 2023 Dec 5. doi: 10.1007/s00259-023-06527-3. Online ahead of print.

PMID: 38049658

 

Immunomodulation of NK, NKT and B/T cell subtypes in relapsed/refractory multiple myeloma patients treated with pomalidomide along with velcade and dexamethasone and its association with improved progression-free survival.

Prabhala R, Pierceall WE, Samur M, Potluri LB, Hong K, Peluso T, Talluri S, Wang A, Katiki A, Vangala SD, Buonopane M, Bade V, Seah H, Krogman A, Derebail S, Fulciniti M, Lazo SB, Richardson P, Anderson K, Corre J, Avet-Loiseau H, Thakurta A, Munshi N.

Front Oncol. 2023 Dec 4;13:1271807. doi: 10.3389/fonc.2023.1271807. eCollection 2023.

PMID: 38111533 

 

Increased mortality in patients with RA-associated interstitial lung disease: data from a French administrative healthcare database.

Juge PA, Wemeau L, Ottaviani S, Desjeux G, Zhuo J, Vannier-Moreau V, Flipo RM, Crestani B, Dieudé P.

RMD Open. 2023 Dec 1;9(4):e003491. doi: 10.1136/rmdopen-2023-003491.

PMID: 38053461 

 

Cloud security in a bioanalytical world: considerations for use of third-party cloud services for bioanalysis.

Davis S, Mitra-Kaushik S, Woolf E, Evens J, Dawes M, Kentner J, Subbarao N, Sundman P, Rusnak D.

Bioanalysis. 2023 Dec;15(24):1461-1468. doi: 10.4155/bio-2023-0164. Epub 2023 Dec 4.

PMID: 38044848 

 

Nivolumab plus chemotherapy in first-line metastatic non-small-cell lung cancer: results of the phase III CheckMate 227 Part 2 trial.

Borghaei H, O'Byrne KJ, Paz-Ares L, Ciuleanu TE, Yu X, Pluzanski A, Nagrial A, Havel L, Kowalyszyn RD, Valette CA, Brahmer JR, Reck M, Ramalingam SS, Zhang L, Ntambwe I, Rabindran SK, Nathan FE, Balli D, Wu YL.

ESMO Open. 2023 Dec;8(6):102065. doi: 10.1016/j.esmoop.2023.102065. Epub 2023 Nov 20.

PMID: 37988950

 

Risk profiles and incidence of cardiovascular events across different cancer types.

Mitchell JD, Laurie M, Xia Q, Dreyfus B, Jain N, Jain A, Lane D, Lenihan DJ.

ESMO Open. 2023 Dec;8(6):101830. doi: 10.1016/j.esmoop.2023.101830. Epub 2023 Nov 17.

PMID: 37979325 

 

Understanding the lived experience of chronic pain: A systematic review and synthesis of qualitative evidence syntheses.

van Rysewyk S, Blomkvist R, Chuter A, Crighton R, Hodson F, Roomes D, Smith BH, Toye F.

Br J Pain. 2023 Dec;17(6):592-605. doi: 10.1177/20494637231196426. Epub 2023 Aug 25.

PMID: 37969135 

 

Neoadjuvant nivolumab plus chemotherapy versus chemotherapy for resectable NSCLC: subpopulation analysis of Chinese patients in CheckMate 816.

Wang C, Chen KN, Chen Q, Wu L, Wang Q, Li X, Ying K, Wang W, Zhao J, Liu L, Fu J, Zhang C, Liu J, Hu Y, Ntambwe I, Cai J, Bushong J, Tran P, Lu S.

ESMO Open. 2023 Dec;8(6):102040. doi: 10.1016/j.esmoop.2023.102040. Epub 2023 Nov 1.

PMID: 37922691  

 

First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants.

Merali S, Wang Z, Frost C, Meadows-Shropshire S, Hawthorne D, Yang J, Seiffert D.

Platelets. 2023 Dec;34(1):2222846. doi: 10.1080/09537104.2023.2222846.

PMID: 37394920

 

Real-world treatment patterns and healthcare costs in patients with psoriasis taking systemic oral or biologic therapies.

Thai S, Zhuo J, Zhong Y, Xia Q, Chen X, Bao Y, Dhanda D, Priya L, Wu JJ.

J Dermatolog Treat. 2023 Dec;34(1):2176708. doi: 10.1080/09546634.2023.2176708.

PMID: 36794863

 

Current approaches to evaluate the function of cytotoxic T-cells in non-human primates.

Kamperschroer C, Frank B, Genell C, Lebrec H, Mitchell-Ryan S, Molinier B, Newsome C, Piche MS, Weinstock D, Collinge M, Freebern W, Rubio D.

J Immunotoxicol. 2023 Dec;20(1):2176952. doi: 10.1080/1547691X.2023.2176952.

PMID: 36788724 

 

Treatment patterns and healthcare costs among patients with psoriasis initiating apremilast or biologics: a retrospective claims database cohort analysis.

Wu JJ, Wang CA, Jobson G, Davidson D, Kalirai S, Zhu J, Suryavanshi M, Mittal M, Patel V, Seigel L.

J Dermatolog Treat. 2023 Dec;34(1):2177095. doi: 10.1080/09546634.2023.2177095.

PMID: 36736349 

 

Pharmacokinetics and Safety of the Tyrosine Kinase 2 Inhibitor Deucravacitinib in Healthy Chinese Subjects.

Jing S, Lin Y, Dockens R, Marchisin D, He B, Girgis IG, Chimalakonda A, Murthy B, Aras U.

Dermatol Ther (Heidelb). 2023 Dec;13(12):3153-3164. doi: 10.1007/s13555-023-01050-7. Epub 2023 Nov 19.

PMID: 37981596 

 

Evaluating stored platelet shape change using imaging flow cytometry.

Özpolat T, Yakovenko O, Stratiievska A, Bailey SL, Miles J, Usaneerungrueng C, Byrne D, Wu X, Stolla M.

Platelets. 2023 Dec;34(1):2136646. doi: 10.1080/09537104.2022.2136646. Epub 2022 Nov 2.

PMID: 36325604

 

Cardiovascular Safety of Ozanimod in Patients With Ulcerative Colitis: True North and Open-Label Extension Analyses.

Armuzzi A, Cross RK, Lichtenstein GR, Hou J, Deepak P, Regueiro M, Wolf DC, Akukwe L, Ahmad HA, Jain A, Kozinn M, Wu H, Petersen A, Charles L, Long M.

Clin Gastroenterol Hepatol. 2023 Nov 30:S1542-3565(23)00956-4. doi: 10.1016/j.cgh.2023.11.018. Online ahead of print.

PMID: 38040274 

 

Evaluation of tissue- and plasma-derived tumor mutational burden (TMB) and genomic alterations of interest in CheckMate 848, a study of nivolumab combined with ipilimumab and nivolumab alone in patients with advanced or metastatic solid tumors with high TMB.

He J, Kalinava N, Doshi P, Pavlick DC, Albacker LA, Ebot EM, Tukachinsky H, Pratt J, Fusaro G, Oxnard GR, Green G, Fabrizio D, Baden J.

J Immunother Cancer. 2023 Nov 30;11(11):e007339. doi: 10.1136/jitc-2023-007339.

PMID: 38035725

 

Survival Outcomes and Health-Related Quality of Life in Older Adults Diagnosed with Acute Myeloid Leukemia Receiving Frontline Therapy in Daily Practice.

Ramos F, Hermosín ML, Fuertes-Núñez M, Martínez P, Rodriguez-Medina C, Barrios M, Ibáñez F, Bernal T, Olave MT, Álvarez MÁ, Vahí M, Caballero-Velázquez T, González B, Altés A, García L, Fernández P, Durán MA, López R, Rafel M, Serrano J.

J Pers Med. 2023 Nov 28;13(12):1667. doi: 10.3390/jpm13121667.

PMID: 38138894 

 

Trends in cardiac rehabilitation rates among patients admitted for acute heart failure in Japan, 2009-2020.

Kim J, Jiang J, Shen S, Setoguchi S.

PLoS One. 2023 Nov 28;18(11):e0294844. doi: 10.1371/journal.pone.0294844. eCollection 2023.

PMID: 38015991 

 

Propensity score-incorporated adaptive design approaches when incorporating real-world data.

Lu N, Chen WC, Li H, Song C, Tiwari R, Wang C, Xu Y, Yue LQ.

Pharm Stat. 2023 Nov 28. doi: 10.1002/pst.2347. Online ahead of print.

PMID: 38014753

 

Controlled synthesis of polycarbonate diols and their polylactide block copolymers using amino-bis(phenolate) chromium hydroxide complexes.

Ni K, Dawe LN, Sarjeant AA, Kozak CM.

Dalton Trans. 2023 Nov 28;52(46):17249-17257. doi: 10.1039/d3dt03168c.

PMID: 37966801

 

Real-World Treatment Patterns and Effectiveness of Patients With Advanced Renal Cell Carcinoma: A Nationwide Observational Study.

Albigès L, Bellera C, Branchoux S, Arnaud M, Gouverneur A, Néré S, Gaudin AF, Durand-Zaleski I, Négrier S.

Clin Genitourin Cancer. 2023 Nov 24:S1558-7673(23)00263-X. doi: 10.1016/j.clgc.2023.11.012. Online ahead of print.

PMID: 38105152 

 

Accelerating development of engineered T cell therapies in the EU: current regulatory framework for studying multiple product versions and T2EVOLVE recommendations.

Ammar D, Schapitz I, Luu M, Hudecek M, Meyer M, Taps T, Schröder B, Ivics Z, Sanges C, Franz P, Koehl U, Negre H, Johanna I, Awigena-Cook J.

Front Immunol. 2023 Nov 24;14:1280826. doi: 10.3389/fimmu.2023.1280826. eCollection 2023.

PMID: 38077331  

 

Zanubrutinib in Mantle Cell Lymphoma Management: A Comprehensive Review.

Alsuhebany N, Pan C, Holovac E, Do B, McBride A.

Blood Lymphat Cancer. 2023 Nov 24;13:67-76. doi: 10.2147/BLCTT.S426588. eCollection 2023.

PMID: 38034984

 

DGKα/ζ inhibition lowers the TCR affinity threshold and potentiates antitumor immunity.

Kureshi R, Bello E, Kureshi CTS, Walsh MJ, Lippert V, Hoffman MT, Dougan M, Longmire T, Wichroski M, Dougan SK.

Sci Adv. 2023 Nov 24;9(47):eadk1853. doi: 10.1126/sciadv.adk1853. Epub 2023 Nov 24.

PMID: 38000024 

 

Real-world outcomes with fedratinib therapy in patients who discontinued ruxolitinib for primary myelofibrosis.

Passamonti F, Lou Y, Chevli M, Abraham P.

Future Oncol. 2023 Nov 22. doi: 10.2217/fon-2022-1256. Online ahead of print.

PMID: 37991002 

 

Ligand-Enabled Carboamidation of Unactivated Alkenes through Enhanced Organonickel Electrophilicity.

Hwang Y, Wisniewski SR, Engle KM.

J Am Chem Soc. 2023 Nov 22;145(46):25293-25303. doi: 10.1021/jacs.3c08855. Epub 2023 Nov 8.

PMID: 37938051

 

The Association between Direct Oral Anticoagulants Prescribing Behavior and Non-Valvular Atrial Fibrillation Outcomes: An Instrumental Variable Analysis of Real-World Data.

Atreja N, Severtson SG, Jiang J, Gao C, Hines DM, Cheng D, Hagan M, Breeze JL, Paulus JK, Secemsky EA.

J Clin Med. 2023 Nov 20;12(22):7190. doi: 10.3390/jcm12227190.

PMID: 38002802 

 

Real-World Utilization of Radiation Therapy in Multiple Myeloma: An Analysis of the Connect MM Registry.

Ballas L, Ailawadhi S, Narang M, Gasparetto CJ, Lee HC, Hardin JW, Durie BGM, Toomey K, Omel J, Wagner LI, Abonour R, Terebelo HR, Joshi P, Yu E, Liu L, Rifkin RM, Jagannath S.

Pract Radiat Oncol. 2023 Nov 19:S1879-8500(23)00300-4. doi: 10.1016/j.prro.2023.11.004. Online ahead of print.

PMID: 37984714

 

Use of patient-reported outcomes (PRO) data to complement exposure-response analysis in early clinical cancer drug development.

Xia H, Booth BP, Wang Y, Fan C, Bhatnagar V, Kluetz P, Fourie Zirkelbach J.

J Patient Rep Outcomes. 2023 Nov 17;7(1):116. doi: 10.1186/s41687-023-00651-2.

PMID: 37975967 

 

Relative bioavailability of fedratinib through various alternative oral administration methods in healthy adults.

Chen Y, Wyatt D, Attanasio M, Thomas M, Thomas M, He B, Nishii R, Liu L, Shan V, Xue Y, Carayannopoulos LN, Ogasawara K, Krishna G.

Cancer Chemother Pharmacol. 2023 Nov 13. doi: 10.1007/s00280-023-04612-w. Online ahead of print.

PMID: 37955741

 

The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution-A Theoretical Investigation Using Permeability-Limited, Physiologically Based Pharmacokinetic Modeling.

Gaohua L, Zhang M, Sychterz C, Chang M, Schmidt BJ.

Int J Mol Sci. 2023 Nov 12;24(22):16224. doi: 10.3390/ijms242216224.

PMID: 38003416 

 

Survival outcomes in patients with acute myeloid leukaemia who received subsequent therapy for relapse in QUAZAR AML-001.

Ravandi F, Döhner H, Wei AH, Montesinos P, Pfeilstöcker M, Papayannidis C, Lai Y, Wang K, See WL, de Menezes DL, Petrlik E, Prebet T, Roboz GJ.

Br J Haematol. 2023 Nov 12. doi: 10.1111/bjh.19202. Online ahead of print.

PMID: 37952982

 

Selection of a statistical analysis method for the Glasgow Outcome Scale-Extended endpoint for estimating the probability of favorable outcome in future severe TBI clinical trials.

Wang Y, Yeatts SD, Martin RH, Silbergleit R, Rockswold GL, Barsan WG, Korley FK, Rockswold S, Gajewski BJ.

Stat Med. 2023 Nov 10;42(25):4582-4601. doi: 10.1002/sim.9877. Epub 2023 Aug 20.

PMID: 37599009

 

Brentuximab vedotin with dacarbazine or nivolumab as frontline cHL therapy in older patients ineligible for chemotherapy.

Friedberg JW, Bordoni RE, Patel-Donnelly D, Larson T, Goldschmidt J, Boccia R, Cline VJM, Mamidipalli A, Liu J, Akyol A, Yasenchak C.

Blood. 2023 Nov 9:blood.2022019536. doi: 10.1182/blood.2022019536. Online ahead of print.

PMID: 37946283

 

Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase.

Jeyaraju DV, Alapa M, Polonskaia A, Risueño A, Subramanyam P, Anand A, Ghosh K, Kyriakopoulos C, Hemerich D, Hurren R, Wang X, Gronda M, Ahsan A, Chiu H, Thomas G, Lind EF, Menezes DL, Schimmer AD, Hagner PR, Gandhi A, Thakurta AG.

Haematologica. 2023 Nov 9. doi: 10.3324/haematol.2023.283437. Online ahead of print.

PMID: 37941406 

 

Pomalidomide, Bortezomib, and Dexamethasone in Lenalidomide-Pretreated Multiple Myeloma: A Subanalysis of OPTIMISMM by Frailty and Bortezomib Dose Adjustment.

Oriol A, Dimopoulos M, Schjesvold F, Beksac M, Facon T, Dhanasiri S, Guo S, Mu Y, Hong K, Gentili C, Galli M, Yagci M, Larocca A, Richardson P, Weisel K.

Clin Lymphoma Myeloma Leuk. 2023 Nov 8:S2152-2650(23)02157-2. doi: 10.1016/j.clml.2023.10.009. Online ahead of print.

PMID: 38072743 

 

A mean-field description for the expansion kinetics of activated T cell populations.

Straube R, Schmidt BJ.

Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2305774120. doi: 10.1073/pnas.2305774120. Epub 2023 Nov 1.

PMID: 37910551

 

Essential team science skills for biostatisticians on collaborative research teams.

Slade E, Brearley AM, Coles A, Hayat MJ, Kulkarni PM, Nowacki AS, Oster RA, Posner MA, Samsa G, Spratt H, Troy J, Pomann GM.

J Clin Transl Sci. 2023 Nov 6;7(1):e243. doi: 10.1017/cts.2023.676. eCollection 2023.

PMID: 38033706 

 

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.

de Las Fuentes L, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJ, Munroe PB, Miller CL, Aschard H, Aslibekyan S, Bartz TM, Bielak LF, Chai JF, Cheng CY, Dorajoo R, Feitosa MF, Guo X, Hartwig FP, Horimoto A, Kolčić I, Lim E, Liu Y, Manning AK, Marten J, Musani SK, Noordam R, Padmanabhan S, Rankinen T, Richard MA, Ridker PM, Smith AV, Vojinovic D, Zonderman AB, Alver M, Boissel M, Christensen K, Freedman BI, Gao C, Giulianini F, Harris SE, He M, Hsu FC, Kühnel B, Laguzzi F, Li X, Lyytikäinen LP, Nolte IM, Poveda A, Rauramaa R, Riaz M, Robino A, Sofer T, Takeuchi F, Tayo BO, van der Most PJ, Verweij N, Ware EB, Weiss S, Wen W, Yanek LR, Zhan Y, Amin N, Arking DE, Ballantyne C, Boerwinkle E, Brody JA, Broeckel U, Campbell A, Canouil M, Chai X, Chen YI, Chen X, Chitrala KN, Concas MP, de Faire U, de Mutsert R, de Silva HJ, de Vries PS, Do A, Faul JD, Fisher V, Floyd JS, Forrester T, Friedlander Y, Girotto G, Gu CC, Hallmans G, Heikkinen S, Heng CK, Homuth G, Hunt S, Ikram MA, Jacobs DR Jr, Kavousi M, Khor CC, Kilpeläinen TO, Koh WP, Komulainen P, Langefeld CD, Liang J, Liu K, Liu J, Lohman K, Mägi R, Manichaikul AW, McKenzie CA, Meitinger T, Milaneschi Y, Nauck M, Nelson CP, O…See abstract for full author list ➔

Front Genet. 2023 Nov 2;14:1235337. doi: 10.3389/fgene.2023.1235337. eCollection 2023.

PMID: 38028628 

 

Integrated analysis of randomized controlled trials evaluating bortezomib + lenalidomide + dexamethasone or bortezomib + thalidomide + dexamethasone induction in transplant-eligible newly diagnosed multiple myeloma.

Rosiñol L, Hebraud B, Oriol A, Colin AL, Ríos Tamayo R, Hulin C, Blanchard MJ, Caillot D, Sureda A, Hernández MT, Arnulf B, Mateos MV, Macro M, San-Miguel J, Belhadj K, Lahuerta JJ, Garelik MB, Bladé J, Moreau P.

Front Oncol. 2023 Nov 2;13:1197340. doi: 10.3389/fonc.2023.1197340. eCollection 2023.

PMID: 38023148 

 

Covalent Degrader of the Oncogenic Transcription Factor β-Catenin.

Gowans FA, Forte N, Hatcher J, Huang OW, Wang Y, Poblano BEA, Wertz IE, Nomura DK.

bioRxiv. 2023 Nov 2:2023.10.31.565018. doi: 10.1101/2023.10.31.565018. Preprint.

PMID: 37961622 

 

Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation.

Hong SH, Osa A, Huang OW, Wertz IE, Nomura DK.

bioRxiv. 2023 Nov 2:2023.10.20.563371. doi: 10.1101/2023.10.20.563371. Preprint.

PMID: 37904950  

 

Proteomic Correlates of the Urinary Protein/Creatinine Ratio in Heart Failure With Preserved Ejection Fraction.

Gan S, Zhao L, Salman O, Wang Z, Ebert C, Azzo JD, Dib MJ, Zamani P, Cohen JB, Kammerhoff K, Schafer P, Seiffert DA, Ramirez-Valle F, Gordon DA, Cvijic ME, Gunawardhana K, Liu L, Chang CP, Cappola TP, Chirinos JA.

Am J Cardiol. 2023 Nov 1;206:312-319. doi: 10.1016/j.amjcard.2023.08.146. Epub 2023 Sep 19.

PMID: 37734292

 

The Importance of Assessing Drug Pharmacokinetics and Pharmacodynamics in the Obese Population During Drug Development.

Moore KT, Zannikos PN, Masters JC, Willmann S, Shen J, Frost C.

J Clin Pharmacol. 2023 Nov;63 Suppl 2:S78-S84. doi: 10.1002/jcph.2361.

PMID: 37942912

 

Correction to: Matching-Adjusted Indirect Comparison of the Long-Term Efficacy of Deucravacitinib Versus Adalimumab for Moderate to Severe Plaque Psoriasis.

Armstrong AW, Park SH, Patel V, Hogan M, Wang WJ, Davidson D, Chirikov V.

Dermatol Ther (Heidelb). 2023 Nov;13(11):2605-2607. doi: 10.1007/s13555-023-01043-6.

PMID: 37853229 

 

Short-, Mid-, and Long-Term Efficacy of Deucravacitinib Versus Biologics and Nonbiologics for Plaque Psoriasis: A Network Meta-Analysis.

Armstrong AW, Warren RB, Zhong Y, Zhuo J, Cichewicz A, Kadambi A, Junqueira D, Westley T, Kisa R, Daamen C, Augustin M.

Dermatol Ther (Heidelb). 2023 Nov;13(11):2839-2857. doi: 10.1007/s13555-023-01034-7. Epub 2023 Oct 6.

PMID: 37801281 

 

Long-term utilization and benefit of luspatercept in transfusion-dependent, erythropoiesis-stimulating agent-refractory or -intolerant patients with lower-risk myelodysplastic syndromes with ring sideroblasts.

Platzbecker U, Santini V, Komrokji RS, Zeidan AM, Garcia-Manero G, Buckstein R, Miteva D, Keeperman K, Holot N, Nadal JA, Lai Y, Vodala S, Rosettani B, Giuseppi AC, Yucel A, Fenaux P.

Leukemia. 2023 Nov;37(11):2314-2318. doi: 10.1038/s41375-023-02031-7. Epub 2023 Sep 26.

PMID: 37752285

 

Dynamic Regulatory Assessment: Unpacking the Process Reveals Readiness to Pilot for Europe-An EFPIA View.

Todd I, Faust R, Herrero-Martinez E, Hussain N, Kawinski A, Lennard A, Roux NL, Macdonald J, Mayer M, Palacios R, Dangy-Caye A.

Clin Ther. 2023 Nov;45(11):1142-1147. doi: 10.1016/j.clinthera.2023.08.006. Epub 2023 Sep 11.

PMID: 37704457 

 

Azacitidine (Vidaza^®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015).

Rubio-San-Simón A, van Eijkelenburg NKA, Hoogendijk R, Hasle H, Niemeyer CM, Dworzak MN, Zecca M, Lopez-Yurda M, Janssen JM, Huitema ADR, van den Heuvel-Eibrink MM, Laille EJ, van Tinteren H, Zwaan CM.

Paediatr Drugs. 2023 Nov;25(6):719-728. doi: 10.1007/s40272-023-00588-5. Epub 2023 Sep 11.

PMID: 37695474 

 

A Meta-Analysis of the Efficacy of Pomalidomide-Based Regimens for the Treatment of Relapsed/Refractory Multiple Myeloma After Lenalidomide Exposure.

Davies FE, Leleu X, Vogel P, Dhanasiri S, Le Nouveau P, Weisel K.

Clin Lymphoma Myeloma Leuk. 2023 Nov;23(11):829-837.e1. doi: 10.1016/j.clml.2023.07.010. Epub 2023 Aug 6.

PMID: 37684184 

 

Integration of peripheral blood- and tissue-based biomarkers of response to immune checkpoint blockade in urothelial carcinoma.

Vanguri RS, Smithy JW, Li Y, Zhuang M, Maher CA, Aleynick N, Peng X, Al-Ahmadie H, Funt SA, Rosenberg JE, Iyer G, Bajorin D, Mathews JC, Nadeem S, Panageas KS, Shen R, Callahan MK, Hollmann TJ.

J Pathol. 2023 Nov;261(3):349-360. doi: 10.1002/path.6197. Epub 2023 Sep 5.

PMID: 37667855

 

Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations.

He MM, Zhu SX, Cannon JR, Christensen JK, Duggal R, Gunduz M, Hilgendorf C, Hughes A, Kekessie I, Kullmann M, Leung D, Terjung C, Wang K, Wesche F.

Drug Metab Dispos. 2023 Nov;51(11):1436-1450. doi: 10.1124/dmd.123.001437. Epub 2023 Aug 17.

PMID: 37591731 

 

Complex peptide macrocycle optimization: combining NMR restraints with conformational analysis to guide structure-based and ligand-based design.

Jain AN, Brueckner AC, Jorge C, Cleves AE, Khandelwal P, Cortes JC, Mueller L.

J Comput Aided Mol Des. 2023 Nov;37(11):519-535. doi: 10.1007/s10822-023-00524-2. Epub 2023 Aug 3.

PMID: 37535171 

 

Geographic variation in clinical outcomes and anticoagulation among medicare beneficiaries with non-valvular atrial fibrillation.

Atwater BD, Di Fusco M, Keshishian A, Delinger R, Ferri M, Jiang J, Seigel L, Yuce H, Guo JD.

J Thromb Thrombolysis. 2023 Nov;56(4):626-634. doi: 10.1007/s11239-023-02855-1. Epub 2023 Aug 2.

PMID: 37530954

 

Cortical laminar necrosis mimicking leptomeningeal recurrence in a child with medulloblastoma and epilepsy.

Mironova D, Benjamin P, Zacharoulis S, Stapleton S, Bridges LR, Jacques TS, Mandeville H, Carceller F.

Pediatr Blood Cancer. 2023 Nov;70(11):e30641. doi: 10.1002/pbc.30641. Epub 2023 Aug 29.

PMID: 37644658

Real-world treatment patterns and survival outcomes for patients with stage III non-small cell lung cancer in Spain: a nationwide cohort study.

Provencio M, Carcereny E, López Castro R, Calvo V, Rodríguez Abreu D, Cobo M, Ortega AL, Bernabé R, Guirado M, Massutí B, Del Barco-Morillo E, Bosch-Barrera J, Camps C, Carroll R, Rault C, Chaib C, Penrod J, Vo L, Ralphs E, Daumont MJ.

Transl Lung Cancer Res. 2023 Oct 31;12(10):2113-2128. doi: 10.21037/tlcr-23-176. Epub 2023 Oct 27.

PMID: 38025806 

 

Real-world evidence for regulatory decision-making: updated guidance from around the world.

Burns L, Le Roux N, Kalesnik-Orszulak R, Christian J, Dudinak J, Rockhold F, Khozin S, O'Donnell J.

Front Med (Lausanne). 2023 Oct 30;10:1236462. doi: 10.3389/fmed.2023.1236462. eCollection 2023.

PMID: 38020096 

 

Reproductive justice advocacy efforts among genetic counselors and family planning providers.

Johnstonbaugh HZ, Lee JK, Semesky P, Sagaser KG.

J Genet Couns. 2023 Oct 25. doi: 10.1002/jgc4.1806. Online ahead of print.

PMID: 37877499

 

Snap-on Adaptor for Microtiter Plates to Enable Continuous-Flow Microfluidic Screening and Harvesting of Crystalline Materials.

Coliaie P, Bhawnani RR, Ali R, Kelkar MS, Korde A, Langston M, Liu C, Nazemifard N, Patience DB, Rosenbaum T, Skliar D, Nere NK, Singh MR.

ACS Omega. 2023 Oct 23;8(44):41502-41511. doi: 10.1021/acsomega.3c05478. eCollection 2023 Nov 7.

PMID: 37969966 

 

Real-World Effectiveness of Dasatinib Versus Imatinib in Newly Diagnosed Patients With Chronic Myeloid Leukemia.

Klink AJ, Keating SJ, Brokars J, Feinberg B, Jabbour E.

Clin Lymphoma Myeloma Leuk. 2023 Oct 20:S2152-2650(23)02149-3. doi: 10.1016/j.clml.2023.10.005. Online ahead of print.

PMID: 38135632

 

Bempegaldesleukin Plus Nivolumab in Untreated Advanced Melanoma: The Open-Label, Phase III PIVOT IO 001 Trial Results.

Diab A, Gogas H, Sandhu S, Long GV, Ascierto PA, Larkin J, Sznol M, Franke F, Ciuleanu TE, Pereira C, Muñoz Couselo E, Bronzon Damian F, Schenker M, Perfetti A, Lebbe C, Quéreux G, Meier F, Curti BD, Rojas C, Arriaga Y, Yang H, Zhou M, Ravimohan S, Statkevich P, Tagliaferri MA, Khushalani NI.

J Clin Oncol. 2023 Oct 20;41(30):4756-4767. doi: 10.1200/JCO.23.00172. Epub 2023 Aug 31.

PMID: 37651676  

 

Patient-Level Artificial Intelligence-Enhanced Electrocardiography in Hypertrophic Cardiomyopathy: Longitudinal Treatment and Clinical Biomarker Correlations.

Siontis KC, Abreau S, Attia ZI, Barrios JP, Dewland TA, Agarwal P, Balasubramanyam A, Li Y, Lester SJ, Masri A, Wang A, Sehnert AJ, Edelberg JM, Abraham TP, Friedman PA, Olgin JE, Noseworthy PA, Tison GH.

JACC Adv. 2023 Oct;2(8):100582. doi: 10.1016/j.jacadv.2023.100582. Epub 2023 Sep 13.

PMID: 38076758

 

Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma.

Toner K, Allen CE, Jain S, Kahl B, Leonard J, Wasserstrom H, Friedberg JW, Seibel NL, Kelly K.

EJHaem. 2023 Sep 7;4(4):921-926. doi: 10.1002/jha2.787. eCollection 2023 Nov.

PMID: 38024612 

 

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.

Campagne S, Jutzi D, Malard F, Matoga M, Romane K, Feldmuller M, Colombo M, Ruepp MD, Allain FH.

Nat Commun. 2023 Sep 4;14(1):5366. doi: 10.1038/s41467-023-40254-5.

PMID: 37666821

 

Development and validation of a psoriasis treatment acceptability measure through group concept mapping.

Hudgens S, Howerter A, Keith S, Evans C, Pelletier C.

Health Qual Life Outcomes. 2023 Aug 8;21(1):83. doi: 10.1186/s12955-023-02162-6.

PMID: 37553594 

 

Refinement of Multiconformer Ensemble Models from Multi-temperature X-ray Diffraction Data.

Du S, Wankowicz SA, Yabukarski F, Doukov T, Herschlag D, Fraser JS.

bioRxiv. 2023 May 5:2023.05.05.539620. doi: 10.1101/2023.05.05.539620. Preprint.

PMID: 37205593 

 

Evaluation of BMS-986142, a reversible Bruton's tyrosine kinase inhibitor, for the treatment of rheumatoid arthritis: a phase 2, randomised, double-blind, dose-ranging, placebo-controlled, adaptive design study.

Conaghan PG, Nowak M, Du S, Luo Y, Landis J, Pachai C, Fura A, Catlett IM, Grasela DM, Østergaard M.

Lancet Rheumatol. 2023 May;5(5):e263-e273. doi: 10.1016/S2665-9913(23)00089-9.

PMID: 38251590  

 

Overall Survival and Response with Nivolumab and Relatlimab in Advanced Melanoma.

Long GV, Stephen Hodi F, Lipson EJ, Schadendorf D, Ascierto PA, Matamala L, Salman P, Castillo Gutiérrez E, Rutkowski P, Gogas HJ, Lao CD, Janoski De Menezes J, Dalle S, Arance A, Grob JJ, Keidel S, Shaikh A, Sobiesk AM, Dolfi S, Tawbi HA.

NEJM Evid. 2023 Apr;2(4):EVIDoa2200239. doi: 10.1056/EVIDoa2200239. Epub 2023 Mar 22.

PMID: 38320023 

 

Mass Spectrometry-Based Approaches for the Analysis of Protein Higher Order Structure.

Liu XR, Huang Y.

J Vis Exp. 2023 Mar 3;(193). doi: 10.3791/64979.

PMID: 37602868

 

Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.

Chien HT, Prior H, Andrews L, van Aerts L, Cauvin A, Clarke DO, Datta K, Dempster M, Dybdal N, Freebern W, de Haan L, Herzyk D, Hey A, Kissner T, Kronenberg S, Leach MW, Lee D, Schutte K, Sewell F, Trouba K, Ulrich P, Weir L, van Meer P.

Regul Toxicol Pharmacol. 2023 Feb;138:105329. doi: 10.1016/j.yrtph.2022.105329. Epub 2022 Dec 30.

PMID: 36592682 

 

Treatment Patterns, Survival, Quality of Life, and Healthcare Resource Use Among Patients With Triple-Class Refractory Multiple Myeloma in US Clinical Practice: Findings From the Connect MM Disease Registry.

Lee HC, Ramasamy K, Weisel K, Abonour R, Hardin JW, Rifkin RM, Ailawadhi S, Terebelo HR, Durie BGM, Tang D, Joshi P, Liu L, Jou YM, Che M, Hernandez G, Narang M, Toomey K, Gasparetto C, Wagner LI, Jagannath S.

Clin Lymphoma Myeloma Leuk. 2023 Feb;23(2):112-122. doi: 10.1016/j.clml.2022.11.008. Epub 2022 Nov 23.

PMID: 36567211 

 

Delaying clinical events among patients with non-valvular atrial fibrillation treated with oral anticoagulants: Insights from the ARISTOPHANES study.

Deitelzweig S, Keshishian A, Kang A, Jenkins A, Atreja N, Schuler P, Jiang J, Yuce H, Sun X, Lip GYH.

Eur J Intern Med. 2023 Feb;108:37-42. doi: 10.1016/j.ejim.2022.10.021. Epub 2022 Nov 28.

PMID: 36456387 

 

Physicians' experience in blood supply shortages and the top factors that impact the clinical, economic, and humanistic outcomes of patients with myelodysplastic syndromes in 5 European countries.

Gupta S, Kulasekararaj AG, Costantino H, Grisolano J, Tang J, Jones S, Tang D.

Curr Med Res Opin. 2023 Feb;39(2):239-247. doi: 10.1080/03007995.2022.2151735. Epub 2022 Dec 7.

PMID: 36453466

 

An Intercompany Perspective on Practical Experiences of Predicting, Optimizing and Analyzing High Concentration Biologic Therapeutic Formulations.

Desai PG, Garidel P, Gbormittah FO, Kamen DE, Mills BJ, Narasimhan CN, Singh S, Stokes ESE, Walsh ER.

J Pharm Sci. 2023 Feb;112(2):359-369. doi: 10.1016/j.xphs.2022.11.020. Epub 2022 Nov 25.

PMID: 36442683

 

Long-term survival with first-line nivolumab plus ipilimumab in patients with advanced non-small-cell lung cancer: a pooled analysis.

Borghaei H, Ciuleanu TE, Lee JS, Pluzanski A, Caro RB, Gutierrez M, Ohe Y, Nishio M, Goldman J, Ready N, Spigel DR, Ramalingam SS, Paz-Ares LG, Gainor JF, Ahmed S, Reck M, Maio M, O'Byrne KJ, Memaj A, Nathan F, Tran P, Hellmann MD, Brahmer JR.

Ann Oncol. 2023 Feb;34(2):173-185. doi: 10.1016/j.annonc.2022.11.006. Epub 2022 Nov 19.

PMID: 36414192 

 

SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma.

Leeksma AC, Derks IAM, Garrick B, Jongejan A, Colombo M, Bloedjes T, Trowe T, Leisten JC, Howarth M, Malek M, Mortensen DS, Blease K, Groza MC, Narla RK, Loos R, Kersten MJ, Moerland PD, Guikema JEJ, Kater AP, Eldering E, Filvaroff EH.

Mol Oncol. 2023 Feb;17(2):284-297. doi: 10.1002/1878-0261.13343. Epub 2022 Dec 16.

PMID: 36400430 

 

Current nonclinical approaches for immune assessments of immuno-oncology biotherapeutics.

Grimaldi C, Ibraghimov A, Kiessling A, Rattel B, Ji C, Fuller CL, Brennan FR, Regenass-Lechner F, Shenton J, Price KD, Piché MS, Steeves MA, Prell R, Dudal S, Kronenberg S, Freebern W, Blanset D.

Drug Discov Today. 2023 Feb;28(2):103440. doi: 10.1016/j.drudis.2022.103440. Epub 2022 Nov 12.

PMID: 36375739

 

Deucravacitinib, a Tyrosine Kinase 2 Inhibitor, in Systemic Lupus Erythematosus: A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial.

Morand E, Pike M, Merrill JT, van Vollenhoven R, Werth VP, Hobar C, Delev N, Shah V, Sharkey B, Wegman T, Catlett I, Banerjee S, Singhal S.

Arthritis Rheumatol. 2023 Feb;75(2):242-252. doi: 10.1002/art.42391. Epub 2022 Nov 11.

PMID: 36369798

 

Development of UV-Vis Imaging Compatible Chromatographic Matrix with Application for Injectable Formulation Characterization.

Bock F, Hu A, Cicale V, Larsen SW, Lu X, Østergaard J.

Anal Chem. 2023 Oct 31;95(43):15861-15866. doi: 10.1021/acs.analchem.3c03648. Epub 2023 Oct 19.

PMID: 37857348

 

Association between pathologic response and survival after neoadjuvant therapy in lung cancer.

Deutsch JS, Cimino-Mathews A, Thompson E, Provencio M, Forde PM, Spicer J, Girard N, Wang D, Anders RA, Gabrielson E, Illei P, Jedrych J, Danilova L, Sunshine J, Kerr KM, Tran M, Bushong J, Cai J, Devas V, Neely J, Balli D, Cottrell TR, Baras AS, Taube JM.

Nat Med. 2023 Oct 30. doi: 10.1038/s41591-023-02660-6. Online ahead of print.

PMID: 37903504

 

Cardiovascular outcomes by time-varying New York Heart Association class among patients with obstructive hypertrophic cardiomyopathy: A retrospective cohort study.

Wang Y, Gao W, Han X, Jiang J, Sandler B, Li X, Zema C.

J Med Econ. 2023 Oct 30:1-16. doi: 10.1080/13696998.2023.2277076. Online ahead of print.

PMID: 37902966

 

An integrated approach for early in vitro seizure prediction utilizing hiPSC neurons and human ion channel assays.

Rockley K, Roberts R, Jennings H, Jones K, Davis M, Levesque P, Morton M.

Toxicol Sci. 2023 Oct 30;196(1):126-140. doi: 10.1093/toxsci/kfad087.

PMID: 37632788

 

Two-year follow-up of lisocabtagene maraleucel in relapsed or refractory large B-cell lymphoma in TRANSCEND NHL 001.   

Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang ML, Arnason JE, Purev E, Maloney DG, Andreadis CB, Sehgal A, Solomon SR, Ghosh N, Dehner C, Kim Y, Ogasawara K, Kostic A, Siddiqi T.

Blood. 2023 Oct 27:blood.2023020854. doi: 10.1182/blood.2023020854. Online ahead of print.

PMID: 37890149

 

Molecular complexes of drug combinations: a review of cocrystals, salts, coamorphous systems and amorphous solid dispersions.

Li J, Wang X, Yu D, Zhoujin Y, Wang K.

Int J Pharm. 2023 Oct 25:123555. doi: 10.1016/j.ijpharm.2023.123555. Online ahead of print.

PMID: 37890646

 

DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity.

Wichroski M, Benci J, Liu SQ, Chupak L, Fang J, Cao C, Wang C, Onorato J, Qiu H, Shan Y, Banas D, Powles R, Locke G, Witt A, Stromko C, Qi H, Zheng X, Martin S, Ding M, Gentles R, Meanwell N, Velaparthi U, Olson R, Wee S, Tenney D, Parker CG, Cravatt BF, Lawrence M, Borzilleri R, Lees E.

Sci Transl Med. 2023 Oct 25;15(719):eadh1892. doi: 10.1126/scitranslmed.adh1892. Epub 2023 Oct 25.

PMID: 37878674

 

Industry Review of Best Practices for Risk Management of Drug-Induced Liver Injury from Development to Real-World Use.

Marquez L, Raheja R, Chan-Liston M, Marcinak J, Estilo A, Pineda Salgado L, Jiang J, Chang C, Beninger P.

Drug Saf. 2023 Oct 24. doi: 10.1007/s40264-023-01360-x. Online ahead of print.

PMID: 37874451

 

Cereblon influences the timing of muscle differentiation in Ciona tadpoles.

Long J, Mariossi A, Cao C, Mo Z, Thompson JW, Levine MS, Lemaire LA.

Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2309989120. doi: 10.1073/pnas.2309989120. Epub 2023 Oct 19.

PMID: 37856545

 

Nivolumab for relapsed/refractory classical Hodgkin lymphoma: 5-year survival from the pivotal phase 2 CheckMate 205 study.

Ansell SM, Bröckelmann PJ, von Keudell G, Lee HJ, Santoro A, Zinzani PL, Collins GP, Cohen JB, de Boer JP, Kuruvilla J, Savage KJ, Trněný M, Provencio M, Jäger U, Willenbacher W, Wen R, Akyol A, Mikita-Geoffroy J, Shipp MA, Engert A, Armand P.

Blood Adv. 2023 Oct 24;7(20):6266-6274. doi: 10.1182/bloodadvances.2023010334.

PMID: 37530622

 

Assessing the Content Validity of Preference-Based Measures in Cancer.

Gibson A, Longworth L, Bennett B, Pickard AS, Shaw JW.

Value Health. 2023 Oct 23:S1098-3015(23)06152-1. doi: 10.1016/j.jval.2023.10.006. Online ahead of print.

PMID: 37879402

 

Pediatric model-based dose optimization using a pooled exposure-response safety analysis for nivolumab and nivolumab plus ipilimumab combination in melanoma.

Du S, Zhao Y, Hu Z, Liu S, Roy A, Shen J, Zhu L, Hamuro L.

CPT Pharmacometrics Syst Pharmacol. 2023 Oct 23. doi: 10.1002/psp4.13070. Online ahead of print.

PMID: 37873561

 

A study to assess the efficacy of enasidenib and risk-adapted addition of azacitidine in newly diagnosed IDH2-mutant AML.

Cai SF, Huang Y, Lance JR, Mao HCC, Dunbar A, McNulty S, Druley TE, Li Y, Baer MR, Stock W, Kovacsovics T, Blum W, Schiller GJ, Olin RL, Foran JM, Litzow MR, Lin TL, Patel PA, Foster MC, Boyiadzis M, Collins RH Jr, Chervin J, Shoben AB, Vergilio JA, Heerema NA, Rosenberg L, Chen TL, Yocum AO, Druggan F, Marcus S, Stefanos M, Druker BJ, Mims AS, Borate U, Burd A, Byrd JC, Levine RL, Stein EM.

Blood Adv. 2023 Oct 23:bloodadvances.2023010563. doi: 10.1182/bloodadvances.2023010563. Online ahead of print.

PMID: 37871309

 

Nivolumab plus Gemcitabine-Cisplatin in Advanced Urothelial Carcinoma.

van der Heijden MS, Sonpavde G, Powles T, Necchi A, Burotto M, Schenker M, Sade JP, Bamias A, Beuzeboc P, Bedke J, Oldenburg J, Chatta G, Ürün Y, Ye D, He Z, Valderrama BP, Ku JH, Tomita Y, Filian J, Wang L, Purcea D, Patel MY, Nasroulah F, Galsky MD; CheckMate 901 Trial Investigators.

N Engl J Med. 2023 Oct 22. doi: 10.1056/NEJMoa2309863. Online ahead of print.

PMID: 37870949

 

Enhancing quality and impact of early phase dose-finding clinical trial protocols: SPIRIT Dose-finding Extension (SPIRIT-DEFINE) guidance.

Yap C, Rekowski J, Ursino M, Solovyeva O, Patel D, Dimairo M, Weir CJ, Chan AW, Jaki T, Mander A, Evans TRJ, Peck R, Hayward KS, Calvert M, Rantell KR, Lee S, Kightley A, Hopewell S, Ashby D, Garrett-Mayer E, Isaacs J, Golub R, Kholmanskikh O, Richards DP, Boix O, Matcham J, Seymour L, Ivy SP, Marshall LV, Hommais A, Liu R, Tanaka Y, Berlin J, Espinasse A, de Bono J.

BMJ. 2023 Oct 20;383:e076386. doi: 10.1136/bmj-2023-076386.

PMID: 37863491

 

Enhancing reporting quality and impact of early phase dose-finding clinical trials: CONSORT Dose-finding Extension (CONSORT-DEFINE) guidance.

Yap C, Solovyeva O, de Bono J, Rekowski J, Patel D, Jaki T, Mander A, Evans TRJ, Peck R, Hayward KS, Hopewell S, Ursino M, Rantell KR, Calvert M, Lee S, Kightley A, Ashby D, Chan AW, Garrett-Mayer E, Isaacs JD, Golub R, Kholmanskikh O, Richards D, Boix O, Matcham J, Seymour L, Ivy SP, Marshall LV, Hommais A, Liu R, Tanaka Y, Berlin J, Espinasse A, Dimairo M, Weir CJ.

BMJ. 2023 Oct 20;383:e076387. doi: 10.1136/bmj-2023-076387.

PMID: 37863501

 

Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates.

Zhang HJ, Ociepa M, Nassir M, Zheng B, Lewicki SA, Salmaso V, Baburi H, Nagel J, Mirza S, Bueschbell B, Al-Hroub H, Perzanowska O, Lin Z, Schmidt MA, Eastgate MD, Jacobson KA, Müller CE, Kowalska J, Jemielity J, Baran PS.

Nat Chem. 2023 Oct 19. doi: 10.1038/s41557-023-01347-2. Online ahead of print.

PMID: 37857844

 

Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O-H Activation and Lewis Acid-Catalyzed Fluoride Shuttling.

Moon HW, Lavagnino MN, Lim S, Palkowitz MD, Mandler MD, Beutner GL, Drance MJ, Lipshultz JM, Scola PM, Radosevich AT.

J Am Chem Soc. 2023 Oct 18;145(41):22735-22744. doi: 10.1021/jacs.3c08373. Epub 2023 Oct 9.

PMID: 37812176

 

The best of both worlds: Blending cutting-edge research with clinical processes for a productive exome clinic.

Sullivan JA, Spillmann RC, Schoch K, Walley N, Alkelai A, Stong N, Shea PR, Petrovski S, Jobanputra V, McConkie-Rosell A, Shashi V.

Clin Genet. 2023 Oct 18. doi: 10.1111/cge.14437. Online ahead of print.

PMID: 37853563

 

A Paradigm Shift in Catalysis: Electro- and Photomediated Nickel-Catalyzed Cross-Coupling Reactions.

Palkowitz MD, Emmanuel MA, Oderinde MS.

Acc Chem Res. 2023 Oct 17;56(20):2851-2865. doi: 10.1021/acs.accounts.3c00479. Epub 2023 Sep 29.

PMID: 37772915

 

Best Practices for Microbial Challenge In-use Studies to Evaluate the Microbial Growth Potential of Parenteral Biological Products; Industry and Regulatory Considerations.

Zamiri C, Leiske DL, Hughes PF, Kirwan JP, Der E, Cox E, Warburton R, Goss M, Weiser S, Perez-Brown J, Gopalrathnam G, Liu J, Mehta SB, Shereefa S, Specht S, Aedo SJ, Goldbach P, Jia F, Kuehnle B, Page S, Voeten L, Yi L, Zhu C.

PDA J Pharm Sci Technol. 2023 Oct 17:pdajpst.2022.012806. doi: 10.5731/pdajpst.2022.012806. Online ahead of print.

PMID: 37848203

 

Safety and Effectiveness of Apixaban Versus Warfarin in Japanese Patients with Nonvalvular Atrial Fibrillation Stratified by Renal Function: A Retrospective Cohort Study.

Morimoto T, Hoshino H, Matsuo Y, Ibuki T, Miyata K, Koretsune Y.

Am J Cardiovasc Drugs. 2023 Oct 17. doi: 10.1007/s40256-023-00611-7. Online ahead of print.

PMID: 37847442

 

Acquired CD38 Gene Deletion as a Mechanism of Tumor Antigen Escape in Multiple Myeloma.

Portuguese AJ, Fang M, Tuazon SA, Pont M, Qu X, Shasha C, Comstock ML, Lyons J, Cole G, Newell EW, Glynn E, Soma LA, Green DJ.

Blood Adv. 2023 Oct 16:bloodadvances.2023011295. doi: 10.1182/bloodadvances.2023011295. Online ahead of print.

PMID: 37844282

 

Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial.

Kirkwood J, Del Vecchio M, Weber J, Hoeller C, Grob JJ, Mohr P, Loquai C, Dutriaux C, Chiarion-Sileni V, Mackiewicz J, Rutkowski P, Arenberger P, Quereux G, Meniawy TM, Ascierto PA, Menzies AM, Durani P, Lobo M, Campigotto F, Gastman B, Long GV.

Nat Med. 2023 Oct 16. doi: 10.1038/s41591-023-02583-2. Online ahead of print.

PMID: 37845511

 

Reproducibility and Robustness of a Liver Microphysiological System PhysioMimix LC12 under Varying Culture Conditions and Cell Type Combinations.

Lim AY, Kato Y, Sakolish C, Valdiviezo A, Han G, Bajaj P, Stanko J, Ferguson SS, Villenave R, Hewitt P, Hardwick RN, Rusyn I.

Bioengineering (Basel). 2023 Oct 14;10(10):1195. doi: 10.3390/bioengineering10101195.

PMID: 37892925

 

Reduced Relapse-Free Survival in Colorectal Cancer Patients with Elevated Soluble CD40 Ligand Levels Improved by Vitamin D Supplementation.

Fujimoto H, Fukuzato S, Kanno K, Akutsu T, Ohdaira H, Suzuki Y, Urashima M.

Nutrients. 2023 Oct 13;15(20):4361. doi: 10.3390/nu15204361.

PMID: 37892436

 

Mavacamten for Obstructive Hypertrophic Cardiomyopathy With or Without Hypertension: Post-Hoc Analysis of the EXPLORER-HCM Trial.

Wang A, Spertus JA, Wojdyla DM, Abraham TP, Nilles EK, Owens AT, Saberi S, Cresci S, Sehnert A, Lakdawala NK.

JACC Heart Fail. 2023 Oct 12:S2213-1779(23)00522-X. doi: 10.1016/j.jchf.2023.07.030. Online ahead of print.

PMID: 37855754

 

Changes in the cis-trans isomer selectivity of a reversed-phase liquid chromatography column during use with acidic mobile phase conditions.

Dahlseid T, Florea A, Schulte G, Cash K, Xu X, Tattersall P, Wang Q, Stoll D.

J Chromatogr A. 2023 Oct 11;1708:464371. doi: 10.1016/j.chroma.2023.464371. Epub 2023 Sep 7.

PMID: 37725873

 

Non-contact Laser Interferometer Method to Characterize Tablet Punches: New Methodology to Assess Surface Roughness.

Hughes H, Leane M, Wray PS, Tobyn M.

AAPS PharmSciTech. 2023 Oct 10;24(7):209. doi: 10.1208/s12249-023-02664-y.

PMID: 37817056

Delayed Solid Tumor Presentations in Adolescent and Young Adults Patients in the Bronx.

Offenbacher R, Norris S, Loeb DM, Levy A.

J Adolesc Young Adult Oncol. 2023 Oct 9. doi: 10.1089/jayao.2023.0078. Online ahead of print.

PMID: 37870570

 

Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.

Tomlinson L, Ramsden D, Leite SB, Beken S, Bonzo JA, Brown P, Candarlioglu PL, Chan TS, Chen E, Choi CK, David R, Delrue N, Devine PJ, Ford K, Garcia MI, Gosset JR, Hewitt P, Homan K, Irrechukwu O, Kopec AK, Liras JL, Mandlekar S, Raczynski A, Sadrieh N, Sakatis MZ, Siegel J, Sung K, Sunyovszki I, Van Vleet TR, Ekert JE, Hardwick RN.

Adv Biol (Weinh). 2023 Oct 9:e2300131. doi: 10.1002/adbi.202300131. Online ahead of print.

PMID: 37814378

 

Characteristics, management, and healthcare resources of patients with advanced non-small-cell lung cancer surviving 5 years after nivolumab treatment initiation: A national database analysis.

Assié JB, Grumberg V, Reynaud D, Gaudin AF, Batisse A, Jolivel R, Jouaneton B, Cotté FE, Chouaïd C.

Respir Med Res. 2023 Oct 6;84:101051. doi: 10.1016/j.resmer.2023.101051. Online ahead of print.

PMID: 37897879

 

Can we collect health-related quality of life information from anticoagulated atrial fibrillation participants who have recently experienced a bleed? An observational feasibility study in primary and secondary care in Wales and through a UK online forum.

Hutchings HA, Lanyon KJ, Holland G, Alikhan R, Jenkins R, Laing H, Hughes A, Lobban T, Pollock K, Tod D, Lister S.

BMJ Open. 2023 Oct 6;13(10):e075335. doi: 10.1136/bmjopen-2023-075335.

PMID: 37802619

 

Promoting Catalytic C-Selective Sulfonylation of Cyclopropanols against Conventional O-Sulfonylation Using Readily Available Sulfonyl Chlorides.

Ramar T, Ilangovan A, A M Subbaiah M.

J Org Chem. 2023 Oct 6;88(19):13553-13567. doi: 10.1021/acs.joc.3c01230. Epub 2023 Sep 14.

PMID: 37708032

 

Monitoring of Visible Particles in Parenteral Products by Manual Visual Inspection-Reassessing Size Threshold and Other Particle Characteristics that Define Particle Visibility.

Mazaheri M, Saggu M, Wuchner K, Koulov AV, Nikels F, Chalus P, Das TK, Cash PW, Finkler C, Levitskaya-Seaman SV, Case J, Parsons J, Gonzalez K.

J Pharm Sci. 2023 Oct 5:S0022-3549(23)00411-2. doi: 10.1016/j.xphs.2023.10.002. Online ahead of print.

PMID: 37802369

Antiplatelet Treatment Patterns and Outcomes for Secondary Stroke Prevention in the United Kingdom.

Liu X, Jiang J, Li D, Horrow J, Tamada H, Kahl A, Hariharan V, Avinav A, Li X.

Cardiol Ther. 2023 Oct 4. doi: 10.1007/s40119-023-00332-7. Online ahead of print.

PMID: 37789237

 

Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling.

Zhang B, He J, Gao Y, Levy L, Oderinde MS, Palkowitz MD, Dhar TGM, Mandler MD, Collins MR, Schmitt DC, Bolduc PN, Chen T, Clementson S, Petersen NN, Laudadio G, Bi C, Kawamata Y, Baran PS.

Nature. 2023 Oct 3. doi: 10.1038/s41586-023-06677-2. Online ahead of print.

PMID: 37788684

 

Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 56 Results From the VALOR-HCM Randomized Clinical Trial.

Desai MY, Owens A, Wolski K, Geske JB, Saberi S, Wang A, Sherrid M, Cremer PC, Lakdawala NK, Tower-Rader A, Fermin D, Naidu SS, Smedira NG, Schaff H, McErlean E, Sewell C, Mudarris L, Gong Z, Lampl K, Sehnert AJ, Nissen SE.

JAMA Cardiol. 2023 Oct 1;8(10):968-977. doi: 10.1001/jamacardio.2023.3342.

PMID: 37639243

 

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.

Baumgartner CK, Ebrahimi-Nik H, Iracheta-Vellve A, Hamel KM, Olander KE, Davis TGR, McGuire KA, Halvorsen GT, Avila OI, Patel CH, Kim SY, Kammula AV, Muscato AJ, Halliwill K, Geda P, Klinge KL, Xiong Z, Duggan R, Mu L, Yeary MD, Patti JC, Balon TM, Mathew R, Backus C, Kennedy DE, Chen A, Longenecker K, Klahn JT, Hrusch CL, Krishnan N, Hutchins CW, Dunning JP, Bulic M, Tiwari P, Colvin KJ, Chuong CL, Kohnle IC, Rees MG, Boghossian A, Ronan M, Roth JA, Wu MJ, Suermondt JSMT, Knudsen NH, Cheruiyot CK, Sen DR, Griffin GK, Golub TR, El-Bardeesy N, Decker JH, Yang Y, Guffroy M, Fossey S, Trusk P, Sun IM, Liu Y, Qiu W, Sun Q, Paddock MN, Farney EP, Matulenko MA, Beauregard C, Frost JM, Yates KB, Kym PR, Manguso RT.

Nature. 2023 Oct;622(7984):850-862. doi: 10.1038/s41586-023-06575-7. Epub 2023 Oct 4.

PMID: 37794185 

 

Plasma proteomic associations with genetics and health in the UK Biobank.

Sun BB, Chiou J, Traylor M, Benner C, Hsu YH, Richardson TG, Surendran P, Mahajan A, Robins C, Vasquez-Grinnell SG, Hou L, Kvikstad EM, Burren OS, Davitte J, Ferber KL, Gillies CE, Hedman ÅK, Hu S, Lin T, Mikkilineni R, Pendergrass RK, Pickering C, Prins B, Baird D, Chen CY, Ward LD, Deaton AM, Welsh S, Willis CM, Lehner N, Arnold M, Wörheide MA, Suhre K, Kastenmüller G, Sethi A, Cule M, Raj A; Alnylam Human Genetics; AstraZeneca Genomics Initiative; Biogen Biobank Team; Bristol Myers Squibb; Genentech Human Genetics; GlaxoSmithKline Genomic Sciences; Pfizer Integrative Biology; Population Analytics of Janssen Data Sciences; Regeneron Genetics Center; Burkitt-Gray L, Melamud E, Black MH, Fauman EB, Howson JMM, Kang HM, McCarthy MI, Nioi P, Petrovski S, Scott RA, Smith EN, Szalma S, Waterworth DM, Mitnaul LJ, Szustakowski JD, Gibson BW, Miller MR, Whelan CD.

Nature. 2023 Oct;622(7982):329-338. doi: 10.1038/s41586-023-06592-6. Epub 2023 Oct 4.

PMID: 37794186 

 

DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies.

Johnson R, Otway R, Chin E, Horvat C, Ohanian M, Wilcox JAL, Su Z, Prestes P, Smolnikov A, Soka M, Guo G, Rath E, Chakravorty S, Chrzanowski L, Hayward CS, Keogh AM, Macdonald PS, Giannoulatou E, Chang ACY, Oates EC, Charchar F, Seidman JG, Seidman CE, Hegde M, Fatkin D.

Circ Genom Precis Med. 2023 Oct;16(5):421-430. doi: 10.1161/CIRCGEN.123.004221. Epub 2023 Sep 6.

PMID: 37671549

 

Comparative effectiveness of treatments for rheumatoid arthritis in clinical practice: A systematic review.

Sparks JA, Harrold LR, Simon TA, Wittstock K, Kelly S, Lozenski K, Khaychuk V, Michaud K.

Semin Arthritis Rheum. 2023 Oct;62:152249. doi: 10.1016/j.semarthrit.2023.152249. Epub 2023 Aug 6.

PMID: 37573754 

 

SARS-CoV-2 vaccination and infection in ozanimod-treated participants with relapsing multiple sclerosis.

Cree BAC, Maddux R, Bar-Or A, Hartung HP, Kaur A, Brown E, Li Y, Hu Y, Sheffield JK, Silva D, Harris S.

Ann Clin Transl Neurol. 2023 Oct;10(10):1725-1737. doi: 10.1002/acn3.51862. Epub 2023 Aug 7.

PMID: 37550942

 

Model based assessment of food and acid reducing agent effects on oral absorption of mezigdomide (CC-92480), a novel cereblon E3 ligase modulator.

Wu F, Liu L, Gaudy A, Wang X, Carayannopoulos L, Pourdehnad M, Lamba M.

CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1473-1484. doi: 10.1002/psp4.13024. Epub 2023 Sep 13.

PMID: 37705327

 

Pharmacokinetics, safety, and tolerability of BMS-986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment.

Qosa H, de Oliveira CHMC, Cizza G, Lawitz EJ, Colletti N, Wetherington J, Charles ED, Tirucherai GS.

Clin Transl Sci. 2023 Oct;16(10):1791-1802. doi: 10.1111/cts.13581. Epub 2023 Aug 31.

PMID: 37654022

 

Compliance and regulatory considerations for the implementation of the multi-attribute-method by mass spectrometry in a quality control laboratory.

Gervais A, Dirksen EHC, Pohl T, Bechtold-Peters K, Burkitt W, D'Alessio V, Greven S, Lennard A, Li X, Lössner C, Niu B, Reusch D, O'Riordan T, Shearer JW, Spencer D, Xu W, Yi L.

Eur J Pharm Biopharm. 2023 Oct;191:57-67. doi: 10.1016/j.ejpb.2023.08.008. Epub 2023 Aug 13.

PMID: 37582411

 

Absolute and Relative Bioavailability of Oral Solid Dosage Formulations of Deucravacitinib in Humans.

Chimalakonda A, Li W, Marchisin D, He B, Singhal S, Deshpande P, Brown J, Aras U, Murthy B.

Clin Pharmacol Drug Dev. 2023 Oct;12(10):956-965. doi: 10.1002/cpdd.1308. Epub 2023 Aug 16.

PMID: 37587797

 

Post-infusion Costs Associated with Idecabtagene Vicleucel Treatment for Patients with Relapsed/Refractory Multiple Myeloma in the KarMMa Trial.

McGarvey N, Ung B, Carattini T, Imanak K, Lee A, Campbell TB, Patwardhan P.

Adv Ther. 2023 Oct;40(10):4626-4638. doi: 10.1007/s12325-023-02623-w. Epub 2023 Aug 19.

PMID: 37597153

 

Correction to: First-line nivolumab plus ipilimumab in metastatic non-small cell lung cancer: 5-year outcomes in Japanese patients from CheckMate 227 Part 1.

Nishio M, Ohe Y, Ikeda S, Yokoyama T, Hayashi H, Fukuhara T, Sato Y, Tanaka H, Hotta K, Sugawara S, Daga H, Okamoto I, Kasahara K, Naito T, Li L, Gupta RG, Bushong J, Mizutani H.

Int J Clin Oncol. 2023 Oct;28(10):1369-1370. doi: 10.1007/s10147-023-02408-9.

PMID: 37684530

 

First-line nivolumab plus ipilimumab in metastatic non-small cell lung cancer: 5-year outcomes in Japanese patients from CheckMate 227 Part 1.

Nishio M, Ohe Y, Ikeda S, Yokoyama T, Hayashi H, Fukuhara T, Sato Y, Tanaka H, Hotta K, Sugawara S, Daga H, Okamoto I, Kasahara K, Naito T, Li L, Gupta RG, Bushong J, Mizutani H.

Int J Clin Oncol. 2023 Oct;28(10):1354-1368. doi: 10.1007/s10147-023-02390-2. Epub 2023 Aug 7.

PMID: 37548831

 

Real-World Effectiveness, Safety, and Health-Related Quality of Life in Patients Receiving Adjuvant Nivolumab for Melanoma in Belgium and Luxembourg: Results of PRESERV MEL.

Rogiers A, Willemot L, McDonald L, Van Campenhout H, Berchem G, Jacobs C, Blockx N, Rorive A, Neyns B.

Cancers (Basel). 2023 Sep 30;15(19):4823. doi: 10.3390/cancers15194823.

PMID: 37835517

 

Correction to: An IQ consortium analysis of starting dose selection for oncology small molecule first‑in‑patient trials suggests an alternative NOAEL‑based method can be safe while reducing time to the recommended phase 2 dose.

Jessen BA, Cornwell P, Redmond S, Visalli T, Lemper M, Bunch T, Hart T.

Cancer Chemother Pharmacol. 2023 Sep 29. doi: 10.1007/s00280-023-04595-8. Online ahead of print.

PMID: 37773538

 

Effectiveness of a treat-to-target strategy in patients with moderate to severely active rheumatoid arthritis treated with abatacept.

Bessette L, Haraoui B, Rampakakis E, Dembowy J, Trépanier MO, Pope J.

Arthritis Res Ther. 2023 Sep 28;25(1):183. doi: 10.1186/s13075-023-03151-2.

PMID: 37759330

 

Transgenic Mice Expressing Functional TCRs Specific to Cardiac Myhc-α 334-352 on Both CD4 and CD8 T Cells Are Resistant to the Development of Myocarditis on C57BL/6 Genetic Background.

Sur M, Rasquinha MT, Arumugam R, Massilamany C, Gangaplara A, Mone K, Lasrado N, Yalaka B, Doiphode A, Gurumurthy C, Steffen D, Reddy J.

Cells. 2023 Sep 25;12(19):2346. doi: 10.3390/cells12192346.

PMID: 37830560

 

Real-World Use of Fedratinib for Myelofibrosis Following Prior Ruxolitinib Failure: Patient Characteristics, Treatment Patterns, and Clinical Outcomes.

Mascarenhas J, Harrison C, Schuler TA, Liassou D, Garretson M, Miller TA, Mahadevan S, McBride A, Tang D, DeGutis IS, Abraham P, Kish J, Feinberg BA, Gerds AT.

Clin Lymphoma Myeloma Leuk. 2023 Sep 29:S2152-2650(23)02130-4. doi: 10.1016/j.clml.2023.09.008. Online ahead of print.

PMID: 37839939

 

Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models.

Ruiu R, Cossu C, Iacoviello A, Conti L, Bolli E, Ponzone L, Magri J, Rumandla A, Calautti E, Cavallo F.

J Exp Clin Cancer Res. 2023 Sep 29;42(1):254. doi: 10.1186/s13046-023-02830-x.

PMID: 37770957

 

The Importance of Tracking "Missing" Metabolites: How and Why?

Wang S, Ballard TE, Christopher LJ, Foti RS, Gu C, Khojasteh SC, Liu J, Ma S, Ma B, Obach RS, Schadt S, Zhang Z, Zhang D.

J Med Chem. 2023 Sep 28. doi: 10.1021/acs.jmedchem.3c01293. Online ahead of print.

PMID: 37769129 Review.

Effects of Omeprazole and Verapamil on the Pharmacokinetics, Safety, and Tolerability of Mavacamten: Two Drug-Drug Interaction Studies in Healthy Participants.

Perera V, Gretler DD, Seroogy JD, Chiang M, Palmisano M, Florea V.

Clin Pharmacol Drug Dev. 2023 Sep 28. doi: 10.1002/cpdd.1332. Online ahead of print.

PMID: 37771180

 

Diversity in clinical trials in Europe and the USA: a review of a pharmaceutical company's data collection, reporting, and interpretation of race and ethnicity.

Candelario NM, Major J, Dreyfus B, Sattler D, Paulucci D, Misra S, Micsinai M, Kuri L.

Ann Oncol. 2023 Sep 27:S0923-7534(23)03945-5. doi: 10.1016/j.annonc.2023.09.3107. Online ahead of print.

PMID: 37774795

 

Industry Perspective on Temperature Cycling Studies to Meet Regulatory Temperature Excursion Support Requirements: Survey Outcome and Recommendations.

Arana C, Ji J, Krug E, Liu J, McCaig L, Rozaieski B, Santos C, Sloan J, St Charles AM, Wiegeshoff F.

J Pharm Sci. 2023 Sep 27:S0022-3549(23)00378-7. doi: 10.1016/j.xphs.2023.09.014. Online ahead of print.

PMID: 37774951 

Utilization of OATP1B Biomarker Coproporphyrin-I to Guide Drug-Drug Interaction Risk Assessment: Evaluation by the Pharmaceutical Industry.

Kikuchi R, Chothe PP, Chu X, Huth F, Ishida K, Ishiguro N, Jiang R, Shen H, Stahl SH, Varma MVS, Willemin ME, Morse BL.

Clin Pharmacol Ther. 2023 Sep 26. doi: 10.1002/cpt.3062. Online ahead of print.

PMID: 37750401

 

ACOEM Guidance Statement Update Role and Value of the Corporate Medical Director.

Stave GM, Burton WN, Heron RJL, Hudson TW, Pawlecki JB, Roomes D, Sepulveda MJ, Rendel M, Hymel PA; ACOEM Corporate Medicine Section Task Force.

J Occup Environ Med. 2023 Sep 25. doi: 10.1097/JOM.0000000000002979. Online ahead of print.

PMID: 37757772

 

Lack of improvement in anorectal manometry parameters after implementation of a pelvic floor/anal sphincter biofeedback in persons with motor-incomplete spinal cord injury.

Aloysius MM, Korsten MA, Radulovic M, Singh K, Lyons BL, Cummings T, Hobson J, Kahal S, Spungen AM, Bauman WA.

Neurogastroenterol Motil. 2023 Sep 25:e14667. doi: 10.1111/nmo.14667. Online ahead of print.

PMID: 37743783

 

Nivolumab Plus Chemotherapy for Advanced Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma: Analysis of Number Needed To Treat and Number Needed To Harm.

Sugarman R, Betts KA, Nie X, Hartman J, Nguyen H.

Clin Ther. 2023 Sep 23:S0149-2918(23)00318-1. doi: 10.1016/j.clinthera.2023.08.014. Online ahead of print.

PMID: 37748935

 

Harmonisation of read-across methodology for drug substance extractables and leachables (E&Ls).

Masuda-Herrera M, Rosen HT, Burild A, Broschard T, Bell T, Graham J, Griffin T, Hillegass J, Leavitt P, Huta B, Parris P, Bruen U, Cruz M, Bercu J.

Regul Toxicol Pharmacol. 2023 Sep 23;145:105494. doi: 10.1016/j.yrtph.2023.105494. Online ahead of print.

PMID: 37748702

 

Comprehensive immunophenotyping of solid tumor-infiltrating immune cells reveals the expression characteristics of LAG-3 and its ligands.

Garman B, Jiang C, Daouti S, Kumar S, Mehta P, Jacques MK, Menard L, Manjarrez-Orduno N, Dolfi S, Mukherjee P, Rai SC, Lako A, Koenitzer JD, David JM.

Front Immunol. 2023 Sep 19;14:1151748. doi: 10.3389/fimmu.2023.1151748. eCollection 2023.

PMID: 37795090

 

Neoadjuvant nivolumab + palbociclib + anastrozole for oestrogen receptor-positive/human epidermal growth factor receptor 2-negative primary breast cancer: Results from CheckMate 7A8.

Jerusalem G, Prat A, Salgado R, Reinisch M, Saura C, Borrego MR, Nikolinakos P, Ades F, Filian J, Huang N, Mazzei-Abba A, Tolaney SM.

Breast. 2023 Sep 15;72:103580. doi: 10.1016/j.breast.2023.103580. Online ahead of print.

PMID: 37741273

 

Health-Related Quality of Life With Nivolumab Plus Chemotherapy Versus Chemotherapy in Patients With Advanced Gastric/Gastroesophageal Junction Cancer or Esophageal Adenocarcinoma From CheckMate 649.

Moehler M, Xiao H, Blum SI, Elimova E, Cella D, Shitara K, Ajani JA, Janjigian YY, Garrido M, Shen L, Yamaguchi K, Liu T, Schenker M, Kowalyszyn R, Bragagnoli AC, Bruges R, Montesarchio V, Pazo-Cid R, Hunter S, Davenport E, Wang J, Kondo K, Li M, Wyrwicz L.

J Clin Oncol. 2023 Sep 15:JCO2300170. doi: 10.1200/JCO.23.00170. Online ahead of print.

PMID: 37713657

 

Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma.

Richardson PG, Trudel S, Popat R, Mateos MV, Vangsted AJ, Ramasamy K, Martinez-Lopez J, Quach H, Orlowski RZ, Arnao M, Lonial S, Karanes C, Pawlyn C, Kim K, Oriol A, Berdeja JG, Rodríguez Otero P, Casas-Avilés I, Spirli A, Poon J, Li S, Gong J, Wong L, Lamba M, Pierce DW, Amatangelo M, Peluso T, Maciag P, Katz J, Pourdehnad M, Bahlis NJ; CC-92480-MM-001 Study Investigators.

N Engl J Med. 2023 Sep 14;389(11):1009-1022. doi: 10.1056/NEJMoa2303194. Epub 2023 Aug 30.

PMID: 37646702.

 

Modelling Health State Utilities as a Transformation of Time to Death in Patients with Non-Small Cell Lung Cancer.

Hatswell AJ, Chaudhary MA, Monnickendam G, Moreno-Koehler A, Frampton K, Shaw JW, Penrod JR, Lawrance R.

Pharmacoeconomics. 2023 Sep 14. doi: 10.1007/s40273-023-01314-2. Online ahead of print.

PMID: 37707719

 

Orange Light-Driven C(sp²)-C(sp³) Cross-Coupling via Spin-Forbidden Ir(III) Metallaphotoredox Catalysis.

Xie KA, Bednarova E, Joe CL, Lin C, Sherwood TC, Simmons EM, Lainhart BC, Rovis T.

J Am Chem Soc. 2023 Sep 13;145(36):19925-19931. doi: 10.1021/jacs.3c06285. Epub 2023 Aug 29.

PMID: 37642382

 

Splenic iron decreases without change in volume or liver parameters during luspatercept therapy.

Denton CC, Vodala S, Veluswamy S, Hofstra TC, Coates TD, Wood JC.

Blood. 2023 Sep 13:blood.2023021839. doi: 10.1182/blood.2023021839. Online ahead of print.

PMID: 37704579

 

A quantum chemical interaction energy dataset for accurately modeling protein-ligand interactions.

Spronk SA, Glick ZL, Metcalf DP, Sherrill CD, Cheney DL.

Sci Data. 2023 Sep 12;10(1):619. doi: 10.1038/s41597-023-02443-1.

PMID: 37699937

 

A Novel Risk Prediction Score for Clinically Significant Bleeding in Patients Anticoagulated for Venous Thromboembolism with Active Cancer.

Cohen AT, Wallenhorst C, Choudhuri S, Nassar A, Pollock KG, Martinez C.

Thromb Haemost. 2023 Sep 11. doi: 10.1055/a-2145-7238. Online ahead of print.

PMID: 37527782

 

Recent advances in upstream process development for production of recombinant adeno-associated virus.

Ou J, Tang Y, Xu J, Tucci J, Borys MC, Khetan A.

Biotechnol Bioeng. 2023 Sep 10. doi: 10.1002/bit.28545. Online ahead of print.

PMID: 37691172 

 

Pharmaceutical Forced Degradation (Stress Testing) Endpoints: A Scientific Rationale and Industry Perspective.

Zelesky T, Baertschi SW, Foti C, Allain LR, Hostyn S, Franca JR, Li Y, Marden S, Mohan S, Ultramari M, Huang Z, Adams N, Campbell JM, Jansen PJ, Kotoni D, Laue C.

J Pharm Sci. 2023 Sep 9:S0022-3549(23)00362-3. doi: 10.1016/j.xphs.2023.09.003. Online ahead of print.

PMID: 37690775

 

Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis.

FitzGerald O, Behrens F, Barton A, Bertheussen H, Boutouyrie-Dumont B, Coates L, Davies O, de Wit M, Fagni F, Goodyear CS, Gurke R, Hahnefeld L, Huppertz C, Ioannidis V, Ibberson M, Katz A, Klippstein M, Koehm M, Korish S, Mackay S, Martin DA, O'Sullivan D, Patel K, Rueping S, Schett G, Scholich K, Schwenk JM, Siebert S, Simon D, Vivekanantham A, Pennington SR.

Ther Adv Musculoskelet Dis. 2023 Sep 8;15:1759720X231192315. doi: 10.1177/1759720X231192315. eCollection 2023.

PMID: 37694182

 

Patient Preferences for Adjuvant Treatment in Muscle-Invasive Urothelial Carcinoma: A Multi-Country Discrete Choice Experiment.

King-Concialdi K, Beusterien K, Senglaub SS, Will O, Jaffe DH, Patel MY, Harrison MR.

Patient Prefer Adherence. 2023 Sep 8;17:2237-2248. doi: 10.2147/PPA.S411751. eCollection 2023.

PMID: 37706208

 

Development of a Crystallization-Induced Diastereomer Transformation of Oxime Isomers for the Asymmetric Synthesis of (1S,6R)-3,9-Diazabicyclo[4.2.1]nonane.

Lisnyak VG, Tan Y, Ramirez A, Wisniewski SR, Sarjeant AA.

J Org Chem. 2023 Sep 1;88(17):12493-12501. doi: 10.1021/acs.joc.3c01228. Epub 2023 Aug 23.

PMID: 37610241

 

Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model.

Geerts H, Bergeler S, Walker M, van der Graaf PH, Courade JP.

Sci Rep. 2023 Sep 1;13(1):14342. doi: 10.1038/s41598-023-41382-0.

PMID: 37658103

 

Adverse event costs associated with first-line therapy for advanced non-small cell lung cancer in the United States: An analysis of clinical trials of immune checkpoint inhibitors.

Stenehjem D, Lubinga SJ, Wu A, Betts KA.

J Manag Care Spec Pharm. 2023 Sep;29(9):1054-1064. doi: 10.18553/jmcp.2023.29.9.1054.

PMID: 37610116

 

Summary of Research: Adjuvant Nivolumab Plus Ipilimumab Versus Placebo for Localized Renal Cell Carcinoma After Nephrectomy (CheckMate 914): A Double-Blind, Randomized, Phase 3 Trial.

Motzer RJ, Russo P, Grünwald V, Tomita Y, Zurawski B, Parikh O, Buti S, Barthélémy P, Goh JC, Ye D, Lingua A, Lattouf JB, Albigès L, George S, Shuch B, Sosman J, Staehler M, Vázquez Estévez S, Simsek B, Spiridigliozzi J, Chudnovsky A, Bex A.

Target Oncol. 2023 Sep;18(5):639-641. doi: 10.1007/s11523-023-00987-1. Epub 2023 Sep 2.

PMID: 37659025

 

Subcutaneous abatacept for the treatment of rheumatoid arthritis in routine clinical practice in Germany, Austria, and Switzerland: 2-year retention and efficacy by treatment line and serostatus.

Alten R, Tony HP, Bannert B, Nüßlein H, Rauch C, Connolly SE, Chartier M, Lozenski K, Hackl R, Forster A, Peichl P.

Clin Rheumatol. 2023 Sep;42(9):2321-2334. doi: 10.1007/s10067-023-06649-x. Epub 2023 Jun 14.

PMID: 37314665

 

Idecabtagene vicleucel for relapsed and refractory multiple myeloma: post hoc 18-month follow-up of a phase 1 trial.

Lin Y, Raje NS, Berdeja JG, Siegel DS, Jagannath S, Madduri D, Liedtke M, Rosenblatt J, Maus MV, Massaro M, Petrocca F, Yeri A, Finney O, Caia A, Yang Z, Martin N, Campbell TB, Rytlewski J, Fuller J, Hege K, Munshi NC, Kochenderfer JN.

Nat Med. 2023 Sep;29(9):2286-2294. doi: 10.1038/s41591-023-02496-0. Epub 2023 Aug 17.

PMID: 37592106

 

Lisocabtagene maraleucel for second-line relapsed or refractory large B-cell lymphoma: patient-reported outcomes from the PILOT study.

Gordon LI, Liu FF, Braverman J, Hoda D, Ghosh N, Hamadani M, Hildebrandt GC, Peng L, Guo S, Shi L, Sehgal A.

Haematologica. 2023 Aug 31. doi: 10.3324/haematol.2023.283162. Online ahead of print.

PMID: 37646670

 

Efficacy and safety of approximately 3 years of continuous ozanimod in moderately to severely active ulcerative colitis: interim analysis of the True North open-label extension.

Danese S, Panaccione R, Abreu MT, Rubin DT, Ghosh S, Dignass A, Afzali A, Wolf DC, Chiorean MV, Vermeire S, Jain A, Charles L, Lawlor G, Osterman MT, Wu H, Canavan JB, Petersen AK, Colombel JF, Regueiro M.

J Crohns Colitis. 2023 Aug 31:jjad146. doi: 10.1093/ecco-jcc/jjad146. Online ahead of print.

PMID: 37651686 

 

Retrospective Comparison of Survival Projections for CAR T-Cell Therapies in Large B-Cell Lymphoma.

Peterse EFP, Verburg-Baltussen EJM, Stewart A, Liu FF, Parker C, Treur M, Malcolm B, Klijn SL.

Pharmacoecon Open. 2023 Aug 31. doi: 10.1007/s41669-023-00435-w. Online ahead of print.

PMID: 37651087

 

Staff experiences of the use of virtual consultations in non-surgical oncology systemic anticancer therapy services.

Warnock C, Pelton J, Hilton A.X

Support Care Cancer. 2023 Aug 30;31(9):541. doi: 10.1007/s00520-023-08005-w.

PMID: 37646821

 

3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering.

Tabriz AG, Gonot-Munck Q, Baudoux A, Garg V, Farnish R, Katsamenis OL, Hui HW, Boersen N, Roberts S, Jones J, Douroumis D.

Pharmaceutics. 2023 Aug 29;15(9):2230. doi: 10.3390/pharmaceutics15092230.

PMID: 37765199

 

Engaging an HIV vaccine target through the acquisition of low B cell affinity.

Ronsard L, Yousif AS, Nait Mohamed FA, Feldman J, Okonkwo V, McCarthy C, Schnabel J, Caradonna T, Barnes RM, Rohrer D, Lonberg N, Schmidt A, Lingwood D.

Nat Commun. 2023 Aug 28;14(1):5249. doi: 10.1038/s41467-023-40918-2.

PMID: 37640732

 

The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes.

Billups M, Minervini M, Holstein M, Feroz H, Ranjan S, Hung J, Zydney AL.

Biotechnol J. 2023 Aug 28:e2300265. doi: 10.1002/biot.202300265. Online ahead of print.

PMID: 37641433

 

Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited via inotropic effectors.

Ma W, Del Rio CL, Qi L, Prodanovic M, Mijailovich S, Zambataro C, Gong H, Shimkunas R, Gollapudi S, Nag S, Irving TC.

bioRxiv. 2023 Aug 28:2023.04.10.536292. doi: 10.1101/2023.04.10.536292. Preprint.

PMID: 37090664 

 

Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity: Prespecified Subgroup Analysis of the ANNEXA-4 Study in Japan.

Toyoda K, Arakawa S, Ezura M, Kobayashi R, Tanaka Y, Hasegawa S, Yamashiro S, Komatsu Y, Terasawa Y, Masuno T, Kobayashi H, Oikawa S, Yasaka M.

J Atheroscler Thromb. 2023 Aug 26. doi: 10.5551/jat.64223. Online ahead of print.

PMID: 37635060

 

Demonstration of Physicochemical and Functional Similarity of Biosimilar Adalimumab-aqvh to Adalimumab.

Jiang Y, Arora T, Klakamp S, Davis J, Chandrasekher YA, Young G, Du Y, Yu B, Miller KJ.

Drugs R D. 2023 Aug 26. doi: 10.1007/s40268-023-00437-3. Online ahead of print.

PMID: 37632627

 

Analysis of cellularity in H&E-stained rat bone marrow tissue via deep learning.

Shiffman S, Rios Piedra EA, Adedeji AO, Ruff CF, Andrews RN, Katavolos P, Liu E, Forster A, Brumm J, Fuji RN, Sullivan R.

J Pathol Inform. 2023 Aug 25;14:100333. doi: 10.1016/j.jpi.2023.100333. eCollection 2023.

PMID: 37743975

 

Contribution of the factors to EuroQol 5 Dimensions in rheumatoid arthritis patients achieving low disease activity/remission with abatacept treatment: post-hoc subgroup analyses of the Japanese real-world observational "ORIGAMI" study.

Harigai M, Tanaka E, Inoue E, Tamura N, Misaki K, Azuma T, Hirata S, Hirano F, Taniguchi Y, Mitsuhashi M, Kondo M, Oribe M, Aoki K, Kadode M, Tsuritani K, Yamanaka H.

Mod Rheumatol. 2023 Aug 25:road082. doi: 10.1093/mr/road082. Online ahead of print.

PMID: 37624029

 

Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease.

Tan SPF, Willemin ME, Snoeys J, Shen H, Rostami-Hodjegan A, Scotcher D, Galetin A.

Clin Pharmacol Ther. 2023 Aug 24. doi: 10.1002/cpt.3029. Online ahead of print.

PMID: 37620246

 

Imidazophenothiazine-Based Thermally Activated Delayed Fluorescence Materials with Ultra-Long-Lived Excited States for Energy Transfer Photocatalysis.

Hojo R, Bergmann K, Elgadi SA, Mayder DM, Emmanuel MA, Oderinde MS, Hudson ZM.Y

J Am Chem Soc. 2023 Aug 23;145(33):18366-18381. doi: 10.1021/jacs.3c04132. Epub 2023 Aug 9.

PMID: 37556344

 

In Vitro 3D Spheroid Culture System Displays Sustained T Cell-dependent CLL Proliferation and Survival.

Haselager MV, van Driel BF, Perelaer E, de Rooij D, Lashgari D, Loos R, Kater AP, Moerland PD, Eldering E.

Hemasphere. 2023 Aug 23;7(9):e938. doi: 10.1097/HS9.0000000000000938. eCollection 2023 Sep.

PMID: 37637994

 

Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants.

Hollingsworth SA, Noland CL, Vroom K, Saha A, Sam M, Gao Q, Zhou H, Grandy DU, Singh S, Wen Z, Warren C, Ma XS, Malashock D, Galli J, Go G, Eddins M, Mayhood T, Sathiyamoorthy K, Fridman A, Raoufi F, Gomez-Llorente Y, Patridge A, Tang Y, Chen SJ, Bailly M, Ji C, Kingsley LJ, Cheng AC, Geierstanger BH, Gorman DM, Zhang L, Pande K.

Sci Rep. 2023 Aug 22;13(1):13668. doi: 10.1038/s41598-023-40919-7.

PMID: 37608223

 

Effects of Additives on the Physical Stability and Dissolution of Polymeric Amorphous Solid Dispersions: a Review.

Li J, Wang Y, Yu D.

AAPS PharmSciTech. 2023 Aug 21;24(7):175. doi: 10.1208/s12249-023-02622-8.

PMID: 37603110 

 

Comparative Evaluation of the Powder and Tableting Properties of Regular and Direct Compression Hypromellose from Different Vendors.

Mawla N, Alshafiee M, Gamble J, Tobyn M, Liu L, Walton K, Conway BR, Timmins P, Asare-Addo K.

Pharmaceutics. 2023 Aug 17;15(8):2154. doi: 10.3390/pharmaceutics15082154.

PMID: 37631368

 

Nitrous Oxide Reduced Suicidal Ideation in Treatment-Resistant Major Depression in Exploratory Analysis.

de Leon VC, Kumar A, Nagele P, Palanca BJ, Gott B, Janski A, Zorumski CF, Conway CR.

J Clin Psychiatry. 2023 Aug 16;84(5):22br14725. doi: 10.4088/JCP.22br14725.

PMID: 37585253 

 

Stopper Movement and Headspace (Air Bubble Size) Limitations for 2.25mL Prefilled Syringe.

Evans CM, Oni Y, Paniagua D, Franck J, Dahlheim C, Kulshrestha A.

PDA J Pharm Sci Technol. 2023 Aug 14:pdajpst.2022.012749. doi: 10.5731/pdajpst.2022.012749. Online ahead of print.

PMID: 37580129

 

Adaptive designs for best treatment identification with top-two Thompson sampling and acceleration.

Wang J, Tiwari R.

Pharm Stat. 2023 Aug 12. doi: 10.1002/pst.2331. Online ahead of print.

PMID: 37571869

 

First-Line, Fixed-Duration Nivolumab Plus Ipilimumab Followed by Nivolumab in Clinically Diverse Patient Populations With Unresectable Stage III or IV Melanoma: CheckMate 401.

Dummer R, Corrie P, Gutzmer R, Meniawy TM, Del Vecchio M, Lebbé C, Guida M, Dutriaux C, Dreno B, Meyer N, Ferrucci PF, Dalle S, Khattak MA, Grob JJ, Briscoe K, Larkin J, Mansard S, Lesimple T, Guidoboni M, Sabatini S, Richtig E, Herbst R, Lobo M, Askelson M, Ascierto PA, Maio M.

J Clin Oncol. 2023 Aug 10;41(23):3917-3929. doi: 10.1200/JCO.22.02199. Epub 2023 Jun 12.

PMID: 37307514 

 

Mechanistic Investigations of Phenoxyimine-Cobalt(II)-Catalyzed C(sp²)-C(sp³) Suzuki-Miyaura Cross-Coupling.

Mills LR, Gygi D, Simmons EM, Wisniewski SR, Kim J, Chirik PJ.

J Am Chem Soc. 2023 Aug 9;145(31):17029-17041. doi: 10.1021/jacs.3c02103. Epub 2023 Jul 25.

PMID: 37490763

 

Erratum to "Aligning tumor mutational burden (TMB) quantification across diagnostic platforms: phase II of the Friends of Cancer Research TMB Harmonization Project": [Annals of Oncology 32 (2021) 1626-1636].

Vega DM, Yee LM, McShane LM, Williams PM, Chen L, Vilimas T, Fabrizio D, Funari V, Newberg J, Bruce LK, Chen SJ, Baden J, Carl Barrett J, Beer P, Butler M, Cheng JH, Conroy J, Cyanam D, Eyring K, Garcia E, Green G, Gregersen VR, Hellmann MD, Keefer LA, Lasiter L, Lazar AJ, Li MC, MacConaill LE, Meier K, Mellert H, Pabla S, Pallavajjalla A, Pestano G, Salgado R, Samara R, Sokol ES, Stafford P, Budczies J, Stenzinger A, Tom W, Valkenburg KC, Wang XZ, Weigman V, Xie M, Xie Q, Zehir A, Zhao C, Zhao Y, Stewart MD, Allen J; TMB Consortium.

Ann Oncol. 2023 Aug 7:S0923-7534(23)00770-6. doi: 10.1016/j.annonc.2023.07.005. Online ahead of print.

PMID: 37558578

 

Estimating the Cost per Clinical Outcome of Second-Line Liso-Cel Versus Autologous Stem Cell Transplantation in Patients with Transplantation-Intended Relapsed/Refractory Large B Cell Lymphoma.

Saeedian M, Badaracco J, Botros A, Gitlin M, Keating SJ.

Transplant Cell Ther. 2023 Aug 5:S2666-6367(23)01437-9. doi: 10.1016/j.jtct.2023.08.001. Online ahead of print.

PMID: 37544410

 

Proteomic profiling across breast cancer cell lines and models.

Kalocsay M, Berberich MJ, Everley RA, Nariya MK, Chung M, Gaudio B, Victor C, Bradshaw GA, Eisert RJ, Hafner M, Sorger PK, Mills CE, Subramanian K.

Sci Data. 2023 Aug 4;10(1):514. doi: 10.1038/s41597-023-02355-0.

PMID: 37542042

 

The Value of Pharmaceutical Industry-Sponsored Patient Registries in Oncology Clinical Research.

Flick ED, Terebelo HR, Fish S, Kitali A, Mahajan V, Nifenecker M, Sullivan K, Thaler P, Ussery S, Grinblatt DL.

Oncologist. 2023 Aug 3;28(8):657-663. doi: 10.1093/oncolo/oyad110.

PMID: 37285045 

 

Behavior of host-cell-protein-rich aggregates in antibody capture and polishing chromatography.

Herman CE, Min L, Choe LH, Maurer RW, Xu X, Ghose S, Lee KH, Lenhoff AM.

J Chromatogr A. 2023 Aug 2;1702:464081. doi: 10.1016/j.chroma.2023.464081. Epub 2023 May 18.

PMID: 37244165

 

Temporal trends in anticoagulation use and clinical outcomes among medicare beneficiaries with non-valvular atrial fibrillation.

Atwater BD, Guo JD, Keshishian A, Delinger R, Russ C, Rosenblatt L, Jiang J, Yuce H, Ferri M.

J Thromb Thrombolysis. 2023 Aug 2. doi: 10.1007/s11239-023-02838-2. Online ahead of print.

PMID: 37530955

 

Assessment of Oxygen Pulse in Hypertrophic Cardiomyopathy-Reply.

Wheeler MT, Chen YM, Myers J.

JAMA Cardiol. 2023 Aug 1;8(8):796-797. doi: 10.1001/jamacardio.2023.1889.

PMID: 37405726 

 

Organizational Impact of Immunotherapies in Advanced Cancers in France.

Grumberg V, Chouaïd C, Gaudin AF, Le Tourneau C, Marabelle A, Bongiovanni-Delarozière I, Cotté FE, Borget I.

JCO Glob Oncol. 2023 Aug;9:e2300026. doi: 10.1200/GO.23.00026.

PMID: 37595168

Systemic and Intracranial Outcomes With First-Line Nivolumab Plus Ipilimumab in Patients With Metastatic NSCLC and Baseline Brain Metastases From CheckMate 227 Part 1.

Reck M, Ciuleanu TE, Lee JS, Schenker M, Zurawski B, Kim SW, Mahave M, Alexandru A, Peters S, Pluzanski A, Caro RB, Linardou H, Burgers JA, Nishio M, Martinez-Marti A, Azuma K, Axelrod R, Paz-Ares LG, Ramalingam SS, Borghaei H, O'Byrne KJ, Li L, Bushong J, Gupta RG, Grootendorst DJ, Eccles LJ, Brahmer JR.

J Thorac Oncol. 2023 Aug;18(8):1055-1069. doi: 10.1016/j.jtho.2023.04.021. Epub 2023 May 3.

PMID: 37146754

 

Journal of Pharmaceutical Sciences Topic Cluster on Co-Processed Active Pharmaceutical Ingredients (APIs).

Erdemir D, Ferguson S, Marziano I, Hancock B.

J Pharm Sci. 2023 Aug;112(8):2009. doi: 10.1016/j.xphs.2023.05.020. Epub 2023 Jun 4.

PMID: 37279837 

 

Treatment of plaque psoriasis with deucravacitinib (POETYK PSO-1 study): a plain language summary.

Armstrong AW, Gooderham M, Warren RB, Papp KA, Strober B, Thaçi D, Morita A, Szepietowski JC, Imafuku S, Colston E, Throup J, Kundu S, Schoenfeld S, Linaberry M, Banerjee S, Blauvelt A.

Immunotherapy. 2023 Aug;15(12):963-973. doi: 10.2217/imt-2023-0061. Epub 2023 May 7.

PMID: 37150952 

 

Treatment of plaque psoriasis with deucravacitinib (POETYK PSO-2 study): a plain language summary.

Strober B, Thaçi D, Sofen H, Kircik L, Gordon KB, Foley P, Rich P, Paul C, Bagel J, Colston E, Throup J, Kundu S, Sekaran C, Linaberry M, Banerjee S, Papp KA.

Immunotherapy. 2023 Aug;15(11):787-797. doi: 10.2217/imt-2023-0062. Epub 2023 May 7.

PMID: 37150956

 

Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.

Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, Khiroya R, Kos Z, Abduljabbar K, Acosta Haab G, Acs B, Akturk G, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Bouchmaa N, Burgues O, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Ely S, Fernandez-Martín C, Fineberg S, Fox SB, Gallagher WM, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hardas A, Hart SN, Hartman J, Hewitt S, Hida AI, Horlings HM, Husain Z, Hytopoulos E, Irshad S, Janssen EA, Kahila M, Kataoka TR, Kawaguchi K, Kharidehal D, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Ly A, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Minhas FUAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rahman A, Rajpoot NM, Rapoport BL, Rau TT, Reis-Filho JS, Ribeiro JM, Rimm…See abstract for full author list ➔

J Pathol. 2023 Aug;260(5):514-532. doi: 10.1002/path.6165. Epub 2023 Aug 23.

PMID: 37608771

 

Challenges in conducting fractional polynomial and standard parametric network meta-analyses of immune checkpoint inhibitors for first-line advanced renal cell carcinoma.

Petersohn S, McGregor B, Klijn SL, May JR, Ejzykowicz F, Kurt M, Dyer M, Malcolm B, Branchoux S, Nickel K, George S, Kroep S.

J Comp Eff Res. 2023 Aug;12(8):e230004. doi: 10.57264/cer-2023-0004. Epub 2023 Jul 11.

PMID: 37431849

 

Healthcare resources and costs associated with nonvalvular atrial fibrillation in Spain: apixaban versus acenocoumarol.

Colet JC, Mainar AS, Salazar-Mendiguchía J, Del Campo Alonso MI, Echeto A, Larena DV, Sánchez OD.

J Comp Eff Res. 2023 Aug;12(8):e230007. doi: 10.57264/cer-2023-0007. Epub 2023 Jul 25.

PMID: 37489950

 

Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.

Thagaard J, Broeckx G, Page DB, Jahangir CA, Verbandt S, Kos Z, Gupta R, Khiroya R, Abduljabbar K, Acosta Haab G, Acs B, Akturk G, Almeida JS, Alvarado-Cabrero I, Amgad M, Azmoudeh-Ardalan F, Badve S, Baharun NB, Balslev E, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Bouchmaa N, Burgues O, Chardas A, Chon U Cheang M, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dahl AB, Dantas Portela FL, Deman F, Demaria S, Doré Hansen J, Dudgeon SN, Ebstrup T, Elghazawy M, Fernandez-Martín C, Fox SB, Gallagher WM, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hart SN, Hartman J, Hauberg S, Hewitt S, Hida AI, Horlings HM, Husain Z, Hytopoulos E, Irshad S, Janssen EA, Kahila M, Kataoka TR, Kawaguchi K, Kharidehal D, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Ly A, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Minhas FUAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rahman A, Rajpoot NM, …See abstract for full author list ➔

J Pathol. 2023 Aug;260(5):498-513. doi: 10.1002/path.6155. Epub 2023 Aug 23.

PMID: 37608772

 

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases.

Weeks EM, Ulirsch JC, Cheng NY, Trippe BL, Fine RS, Miao J, Patwardhan TA, Kanai M, Nasser J, Fulco CP, Tashman KC, Aguet F, Li T, Ordovas-Montanes J, Smillie CS, Biton M, Shalek AK, Ananthakrishnan AN, Xavier RJ, Regev A, Gupta RM, Lage K, Ardlie KG, Hirschhorn JN, Lander ES, Engreitz JM, Finucane HK.

Nat Genet. 2023 Aug;55(8):1267-1276. doi: 10.1038/s41588-023-01443-6. Epub 2023 Jul 13.

PMID: 37443254

 

Impact of diabetes on remodelling, microvascular function and exercise capacity in aortic stenosis.

Dattani A, Brady EM, Alfuhied A, Gulsin GS, Steadman CD, Yeo JL, Aslam S, Banovic M, Jerosch-Herold M, Xue H, Kellman P, Costet P, Cvijic ME, Zhao L, Ebert C, Liu L, Gunawardhana K, Gordon D, Chang CP, Arnold JR, Yates T, Kelly D, Hogrefe K, Dawson D, Greenwood J, Ng LL, Singh A, McCann GP.

Open Heart. 2023 Aug;10(2):e002441. doi: 10.1136/openhrt-2023-002441.

PMID: 37586847

 

Oral prednisone regulates human skin T cells in delayed-type hypersensitivity reaction elicited by diphencyprone.

Mehta H, Jack C, Maari C, Proulx ÉS, Bissonnette R, Ramirez-Valle F, Sarfati M.

Allergy. 2023 Aug;78(8):2255-2265. doi: 10.1111/all.15764. Epub 2023 May 19.

PMID: 37163280 

 

Safety, Pharmacokinetics, and Antifibrotic Activity of CC-90001 (BMS-986360), a c-Jun N-Terminal Kinase Inhibitor, in Pulmonary Fibrosis.

Horan G, Ye Y, Adams M, Parton A, Cedzik D, Tang S, Brown EA, Liu L, Nissel J, Carayannopoulos LN, Gaudy A, Schafer P, Palmisano M, Ramirez-Valle F.

Clin Pharmacol Drug Dev. 2023 Aug;12(8):779-789. doi: 10.1002/cpdd.1294. Epub 2023 Jun 28.

PMID: 37378860

 

2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization Part 1B - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).

Szapacs M, Jian W, Spellman D, Cunliffe J, Verburg E, Kaur S, Kellie J, Li W, Mehl J, Qian M, Qiu X, Sirtori FR, Rosenbaum AI, Sikorski T, Surapaneni S, Wang J, Wilson A, Zhang J, Xue Y, Post N, Huang Y, Goykhman D, Yuan L, Fang K, Casavant E, Chen L, Fu Y, Huang M, Ji A, Johnson J, Lassman M, Li J, Saad O, Sarvaiya H, Tao L, Wang Y, Zheng N, Dasgupta A, Abhari MR, Ishii-Watabe A, Saito Y, Mendes Fernandes DN, Bower J, Burns C, Carleton K, Cho SJ, Du X, Fjording M, Garofolo F, Kar S, Kavetska O, Kossary E, Lu Y, Mayer A, Palackal N, Salha D, Thomas E, Verhaeghe T, Vinter S, Wan K, Wang YM, Williams K, Woolf E, Yang L, Yang E, Bandukwala A, Hopper S, Maher K, Xu J, Brodsky E, Cludts I, Irwin C, Joseph J, Kirshner S, Manangeeswaran M, Maxfield K, Pedras-Vasconcelos J, Solstad T, Thacker S, Tounekti O, Verthelyi D, Wadhwa M, Wagner L, Yamamoto T, Zhang L, Zhou L.

Bioanalysis. 2023 Aug;15(16):955-1016. doi: 10.4155/bio-2023-0167. Epub 2023 Aug 31.

PMID: 37650500

 

2022 White Paper on Recent Issues in Bioanalysis: Enzyme Assay Validation, BAV for Primary End Points, Vaccine Functional Assays, Cytometry in Tissue, LBA in Rare Matrices, Complex NAb Assays, Spectral Cytometry, Endogenous Analytes, Extracellular Vesicles Part 2 - Recommendations on Biomarkers/CDx, Flow Cytometry, Ligand-Binding Assays Development & Validation; Emerging Technologies; Critical Reagents Deep Characterization.

Sumner G, Keller S, Huleatt J, Staack RF, Wagner L, Azadeh M, Bandukwala A, Cao L, Du X, Salinas GF, Garofolo F, Harris S, Hopper S, Irwin C, Ji Q, Joseph J, King L, Kinhikar A, Lu Y, Luo R, Mabrouk O, Malvaux L, Marshall JC, McGuire K, Mikol V, Neely R, Qiu X, Saito Y, Salaun B, Scully I, Smeraglia J, Solstad T, Stoop J, Tang H, Teixeira P, Wang Y, Wright M, Mendez L, Beaver C, Eacret J, Au-Yeung A, Decman V, Dessy F, Eck S, Goihberg P, Alcaide EG, Gonneau C, Grugan K, Hedrick MN, Kar S, Sehra S, Stevens E, Stevens C, Sun Y, McCush F, Williams L, Fischer S, Wu B, Jordan G, Burns C, Cludts I, Coble K, Grimaldi C, Henderson N, Joyce A, Lotz G, Lu Y, Luo L, Neff F, Sperinde G, Stubenrauch KG, Wang Y, Ware M, Xu W.

Bioanalysis. 2023 Aug;15(15):861-903. doi: 10.4155/bio-2023-0151. Epub 2023 Aug 16.

PMID: 37584363

 

Benefits of Autoantibody Enrichment in Early Rheumatoid Arthritis: Analysis of Efficacy Outcomes in Four Pooled Abatacept Trials.

Michaud K, Conaghan PG, Park SH, Lozenski K, Fillbrunn M, Khaychuk V, Swallow E, Vaile J, Lane H, Nguyen H, Pope J.

Rheumatol Ther. 2023 Aug;10(4):951-967. doi: 10.1007/s40744-023-00552-2. Epub 2023 May 25.

PMID: 37231194

 

Real-world relationship of early end points to survival end points in patients with resectable non-small-cell lung cancer.

Nadler E, Vasudevan A, Wentworth C, Robert N, Penrod JR, Fiore J, Vo L.

Future Oncol. 2023 Aug;19(26):1785-1800. doi: 10.2217/fon-2023-0170. Epub 2023 Sep 4.

PMID: 37665271

 

Genomic Data Heterogeneity across Molecular Diagnostic Laboratories: A Real-World Connect Myeloid Disease Registry Perspective on Variabilities in Genomic Assay Methodology and Reporting.

Patel JL, Erba HP, Savona MR, Grinblatt DL, Clark M, Clive TC, Smart TB, Makinde AY, DeGutis IS, Yu E, Eggington JM, George TI.

J Mol Diagn. 2023 Aug;25(8):611-618. doi: 10.1016/j.jmoldx.2023.05.002.

PMID: 37517825

 

Comparison of Preferences and Data Quality between Discrete Choice Experiments Conducted in Online and Face-to-Face Respondents.

Jiang R, Pullenayegum E, Shaw JW, Mühlbacher A, Lee TA, Walton S, Kohlmann T, Norman R, Pickard AS.

Med Decis Making. 2023 Aug;43(6):667-679. doi: 10.1177/0272989X231171912. Epub 2023 May 18.

PMID: 37199407

 

Correction to: Venetoclax plus azacitidine compared with intensive chemotherapy as induction for patients with acute myeloid leukemia: retrospective analysis of an electronic medical record database in the United States.

Zeidan AM, Pollyea DA, Borate U, Vasconcelos A, Potluri R, Rotter D, Kiendrebeogo Z, Gaugler L, Prebet T, Strocchia M, Bonifacio G, Chen C.

Ann Hematol. 2023 Aug;102(8):2299. doi: 10.1007/s00277-023-05327-x.

PMID: 37341779

 

International Society for Quality of Life Research commentary on the US Food and Drug Administration draft guidance for industry on core patient-reported outcomes in cancer clinical trials.

Brady KJS, Peipert JD, Atkinson TM, Pompili C, Pinto M, Shaw JW, Roydhouse J; International Society for Quality of Life Research Clinical Practice Special Interest Group, the International Society for Quality of Life Research Clinical Practice Special Interest Group, the International Society for Quality of Life Research Regulatory Health, Technology Assessment Engagement Special Interest Group, and the International Society for Quality of Life Research Psychometrics Special Interest Group.

Qual Life Res. 2023 Aug;32(8):2155-2163. doi: 10.1007/s11136-023-03396-z. Epub 2023 May 23.

PMID: 37217665

 

Molecular magnetic resonance imaging of liver inflammation using an oxidatively activated probe.

Jordan VC, Sojoodi M, Shroff S, Pagan PG, Barrett SC, Wellen J, Tanabe KK, Chung RT, Caravan P, Gale EM.

JHEP Rep. 2023 Jul 18;5(10):100850. doi: 10.1016/j.jhepr.2023.100850. eCollection 2023 Oct.

PMID: 37818152

 

2022 White Paper on Recent Issues in Bioanalysis: FDA Draft Guidance on Immunogenicity Information in Prescription Drug Labeling, LNP & Viral Vectors Therapeutics/Vaccines Immunogenicity, Prolongation Effect, ADA Affinity, Risk-based Approaches, NGS, qPCR, ddPCR Assays (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccines Immunogenicity & Technologies; Immunogenicity & Risk Assessment of Biotherapeutics and Novel Modalities; NAb Assays Integrated Approach).

Pan L, Mora J, Walravens K, Wagner L, Hopper S, Loo L, Bettoun D, Bond S, Dessy F, Downing S, Garofolo F, Gupta S, Henderson N, Irwin C, Ishii-Watabe A, Kar S, Jawa V, Joseph J, Malvaux L, Marshall JC, McDevitt J, Mohapatra S, Seitzer J, Smith J, Solstad T, Sugimoto H, Tounekti O, Wu B, Wu Y, Xu Y, Xu J, Yamamoto T, Yang L, Torri A, Kirshner S, Maxfield K, Vasconcelos JP, Abhari MR, Verthelyi D, Brodsky E, Carrasco-Triguero M, Kamerud J, Andisik M, Baltrukonis D, Bivi N, Cludts I, Coble K, Gorovits B, Gunn GR, Gupta S, Millner AH, Joyce A, Kubiak RJ, Kumar S, Liao K, Manangeeswaran M, Partridge M, Pine S, Poetzl J, Rajadhyaksha M, Rasamoelisolo M, Richards S, Song Y, Swanson S, Thacker S, Wadhwa M, Wolf A, Zhang L, Zhou L.

Bioanalysis. 2023 Jul;15(14):773-814. doi: 10.4155/bio-2023-0135. Epub 2023 Aug 1.

PMID: 37526071

 

Association Between Psoriasis and Obesity Among US Adults in the 2009-2014 National Health and Nutrition Examination Survey.

Smith B, Devjani S, Collier MR, Maul JT, Wu JJ.

Cutis. 2023 Jul;112(1):49-51. doi: 10.12788/cutis.0807.

PMID: 37611301

 

Real-world complication burden and disease management paradigms in transfusion-related β-thalassaemia in Greece: Results from ULYSSES, an epidemiological, multicentre, retrospective cross-sectional study.

Kattamis A, Voskaridou E, Delicou S, Klironomos E, Lafiatis I, Petropoulou F, Diamantidis MD, Lafioniatis S, Evliati L, Kapsali E, Karvounis-Marolachakis K, Timotheatou D, Deligianni C, Viktoratos P, Kourakli A.

EJHaem. 2023 May 23;4(3):569-581. doi: 10.1002/jha2.695. eCollection 2023 Aug.

PMID: 37601860

 

Cost-effectiveness of nivolumab and ipilimumab versus pembrolizumab and axitinib in advanced renal cell carcinoma with intermediate or poor prognostic risk: a Brazilian private healthcare system perspective.

Dhanji N, Decimoni TC, Dyer MTD, May JR, van de Wetering G, Petersohn S, Nickel K, Silva A, Muniz DQB, Casagrande D Oliveira AP.

J Med Econ. 2023 Jan-Dec;26(1):1108-1121. doi: 10.1080/13696998.2023.2252716.

PMID: 37632452

 

Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity.

Lietz CB, Deyanova E, Cho Y, Cordia J, Franc S, Kabro S, Wang S, Mikolon D, Banks DD.

MAbs. 2023 Jan-Dec;15(1):2259289. doi: 10.1080/19420862.2023.2259289. Epub 2023 Sep 24.

PMID: 37742207

 

Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT.

Diong SJ, Jashnani A, Drake AW, Bee C, Findeisen F, Dollinger G, Wang F, Rajpal A, Strop P, Lee PS.

MAbs. 2023 Jan-Dec;15(1):2253788. doi: 10.1080/19420862.2023.2253788.

PMID: 37675979

 

An Analysis of Dasatinib Treatment Patterns in Patients with Chronic Myeloid Leukemia after Experiencing Pleural Effusion during Dasatinib Therapy.

McBride A, Brokars J, Reddy SR, Chang E, Tarbox MH, LeBlanc TW.

Acta Haematol. 2023;146(4):259-266. doi: 10.1159/000530512. Epub 2023 Apr 10.

PMID: 37037194

 

Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data.

Du S, Wankowicz SA, Yabukarski F, Doukov T, Herschlag D, Fraser JS.

Methods Enzymol. 2023;688:223-254. doi: 10.1016/bs.mie.2023.06.009. Epub 2023 Jul 27.

PMID: 37748828 

Matching-Adjusted Indirect Comparison of the Long-Term Efficacy of Deucravacitinib Versus Adalimumab for Moderate to Severe Plaque Psoriasis.

Armstrong AW, Park SH, Patel V, Hogan M, Wang WJ, Davidson D, Chirikov V.

Dermatol Ther (Heidelb). 2023 Jul 31. doi: 10.1007/s13555-023-00977-1. Online ahead of print.

PMID: 37525000

 

Analysis of the bile acid composition in a fibroblast growth factor 19-expressing liver-humanized mouse model and its use for CYP3A4-mediated drug-drug interaction studies.

Mezler M, Jones RS, Sangaraju D, Goldman DC, Hoffmann M, Heikkinen AT, Mannila J, Chang JH, Foquet L, Pusalkar S, Chothe PP, Scheer N.

Drug Metab Dispos. 2023 Jul 31:DMD-AR-2023-001398. doi: 10.1124/dmd.123.001398. Online ahead of print.

PMID: 37524541 

 

PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper.

Kavita U, Sun K, Braun M, Lembke W, Mody H, Kamerud J, Yang TY, Braun IV, Fang X, Gao W, Gupta S, Hofer M, Liao MZ, Loo L, McBlane F, Menochet K, Stubenrauch KG, Upreti VV, Vigil A, Wiethoff CM, Xia CQ, Zhu X, Jawa V, Chemuturi N.

AAPS J. 2023 Jul 31;25(5):78. doi: 10.1208/s12248-023-00842-1.

PMID: 37523051 

 

Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions.

Chu J, Panfen E, Wang L, Marino A, Chen XQ, Fancher RM, Landage R, Patil O, Desai SD, Shah D, Xue Y, Sinz M, Shen H.

Pharm Res. 2023 Jul 31. doi: 10.1007/s11095-023-03563-4. Online ahead of print.

PMID: 37523014

 

Payer formulary tier increases of apixaban: how patients respond and potential implications.

Deitelzweig S, Terasawa E, Atreja N, Kang A, Hines DM, Dhamane AD, Hagan M, Noman A, Luo X.

Curr Med Res Opin. 2023 Jul 31:1-9. doi: 10.1080/03007995.2023.2232636. Online ahead of print.

PMID: 37519272

 

The safety profile of nivolumab plus ipilimumab combination therapy in Japanese patients with renal cell carcinoma: results from post-marketing surveillance.

Uemura H, Shinohara N, Tomita Y, Nonomura N, Yamada T, Yoshida A, Komoto A.J

pn J Clin Oncol. 2023 Jul 31;53(8):730-737. doi: 10.1093/jjco/hyad034.

PMID: 37151051 

 

Early Discontinuation of Apremilast in Patients with Psoriasis and Gastrointestinal Comorbidities: Rates and Associated Risk Factors.

Schmidt L, Wang CA, Patel V, Davidson D, Kalirai S, Panda A, Seigel L.

Dermatol Ther (Heidelb). 2023 Jul 30. doi: 10.1007/s13555-023-00975-3. Online ahead of print.

PMID: 37517029

 

Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.

Platzbecker U, Della Porta MG, Santini V, Zeidan AM, Komrokji RS, Shortt J, Valcarcel D, Jonasova A, Dimicoli-Salazar S, Tiong IS, Lin CC, Li J, Zhang J, Giuseppi AC, Kreitz S, Pozharskaya V, Keeperman KL, Rose S, Shetty JK, Hayati S, Vodala S, Prebet T, Degulys A, Paolini S, Cluzeau T, Fenaux P, Garcia-Manero G.

Lancet. 2023 Jul 29;402(10399):373-385. doi: 10.1016/S0140-6736(23)00874-7. Epub 2023 Jun 10.

PMID: 37311468

 

A phase Ib/II study of galunisertib in combination with nivolumab in solid tumors and non-small cell lung cancer.

Nadal E, Saleh M, Aix SP, Ochoa-de-Olza M, Patel SP, Antonia S, Zhao Y, Gueorguieva I, Man M, Estrem ST, Liu J, Avsar E, Lin WH, Benhadji KA, Gandhi L, Guba SC, Diaz IA.

BMC Cancer. 2023 Jul 28;23(1):708. doi: 10.1186/s12885-023-11153-1.

PMID: 37507657  

 

Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients.

Nag S, Gollapudi SK, Del Rio CL, Spudich JA, McDowell R.

Sci Adv. 2023 Jul 28;9(30):eabo7622. doi: 10.1126/sciadv.abo7622. Epub 2023 Jul 28.

PMID: 37506209  

 

An IQ consortium analysis of starting dose selection for oncology small molecule first-in-patient trials suggests an alternative NOAEL-based method can be safe while reducing time to the recommended phase 2 dose.

Jessen BA, Cornwell P, Redmond S, Visalli T, Lemper M, Bunch T, Hart T.

Cancer Chemother Pharmacol. 2023 Jul 28. doi: 10.1007/s00280-023-04570-3. Online ahead of print.

PMID: 37505272

 

Quantitative Systems Toxicology Identifies Independent Mechanisms for Hepatotoxicity and Bilirubin Elevations Due to AKR1C3 Inhibitor BAY1128688.

Battista C, Shoda LKM, Watkins PB, Groettrup-Wolfers E, Rottmann A, Raschke M, Generaux GT.

Clin Pharmacol Ther. 2023 Jul 28. doi: 10.1002/cpt.3010. Online ahead of print.

PMID: 37501650

 

Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.

Zhuo X, Howell BA, Shen H, Woodhead JL, Mosure K, Zhang Y, Scialis RJ, Iyer R, Sun Y, Boy KM, Lentz KA, Denton RR, Soars MG, Johnson BM, Humphreys WG.

Toxicol Sci. 2023 Jul 28;194(2):235-245. doi: 10.1093/toxsci/kfad057.

PMID: 37261863

 

An indirect treatment comparison of efficacy and health-related quality of life following treatment with idecabtagene vicleucel versus belantamab mafodotin in triple-class exposed relapsed/refractory patients with multiple myeloma.

Rodríguez Otero P, Towle K, Cope S, Caisip C, Davies FE, Delforge M, Weisel K, Marshall TS, Karampampa K, Ayers D, Mojebi A, Braverman J, Farrell J, Dhanda D.

Leuk Lymphoma. 2023 Jul 27:1-6. doi: 10.1080/10428194.2023.2235042. Online ahead of print.

PMID: 37497883

 

Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse.

DeWolf S, Elhanati Y, Nichols K, Waters NR, Nguyen CL, Slingerland JB, Rodriguez N, Lyudovyk O, Giardina PA, Kousa AI, Andrlová H, Ceglia N, Fei T, Kappagantula R, Li Y, Aleynick N, Baez P, Murali R, Hayashi A, Lee N, Gipson B, Rangesa M, Katsamakis Z, Dai A, Blouin AG, Arcila M, Masilionis I, Chaligne R, Ponce DM, Landau HJ, Politikos I, Tamari R, Hanash AM, Jenq RR, Giralt SA, Markey KA, Zhang Y, Perales MA, Socci ND, Greenbaum BD, Iacobuzio-Donahue CA, Hollmann TJ, van den Brink MRM, Peled JU.

Sci Transl Med. 2023 Jul 26;15(706):eabq0476. doi: 10.1126/scitranslmed.abq0476. Epub 2023 Jul 26.

PMID: 37494469

 

Lenalidomide treatment of Japanese patients with myelodysplastic syndromes with 5q deletion: a post-marketing surveillance study.

Uno S, Motegi Y, Minehata K, Aoki Y.

Int J Hematol. 2023 Jul 26. doi: 10.1007/s12185-023-03634-7. Online ahead of print.

PMID: 37493867

 

Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia: A Randomized

O'Halloran JA, Ko ER, Anstrom KJ, Kedar E, McCarthy MW, Panettieri RA Jr, Maillo M, Nunez PS, Lachiewicz AM, Gonzalez C, Smith PB, de Tai SM, Khan A, Lora AJM, Salathe M, Capo G, Gonzalez DR, Patterson TF, Palma C, Ariza H, Lima MP, Blamoun J, Nannini EC, Sprinz E, Mykietiuk A, Alicic R, Rauseo AM, Wolfe CR, Witting B, Wang JP, Parra-Rodriguez L, Der T, Willsey K, Wen J, Silverstein A, O'Brien SM, Al-Khalidi HR, Maldonado MA, Melsheimer R, Ferguson WG, McNulty SE, Zakroysky P, Halabi S, Benjamin DK Jr, Butler S, Atkinson JC, Adam SJ, Chang S, LaVange L, Proschan M, Bozzette SA, Powderly WG; ACTIV-1 IM Study Group Members.

JAMA. 2023 Jul 25;330(4):328-339. doi: 10.1001/jama.2023.11043.

PMID: 37428480

 

The ubiquity of the tabletability flip phenomenon.

Wang Z, Wang C, Bahl D, Sun CC.

Int J Pharm. 2023 Jul 24;643:123262. doi: 10.1016/j.ijpharm.2023.123262. Online ahead of print.

PMID: 37495026

 

Time-dependent prognostic value of serological and measurable residual disease assessments after idecabtagene vicleucel.

Paiva B, Manrique I, Rytlewski J, Campbell T, Kazanecki CC, Martin N, Anderson LD, Berdeja JG, Lonial S, Raje NS, Lin Y, Moreau P, San-Miguel JF, Munshi NC, Kaiser S.

Blood Cancer Discov. 2023 Jul 24:BCD-23-0044. doi: 10.1158/2643-3230.BCD-23-0044. Online ahead of print.

PMID: 37486974

 

Remote C-H Olefination of Heterocyclic Biaryls Enabled by Reversibly Bound Templates.

Liu LY, Fan Z, Hoque ME, Qian S, Meng G, Chekshin N, Tanaka K, Qiao JX, Yeung KS, Yu JQ.

Angew Chem Int Ed Engl. 2023 Jul 20:e202307581. doi: 10.1002/anie.202307581. Online ahead of print.

PMID: 37470111

 

Epidemiology and clinical characteristics of interstitial lung disease in patients with rheumatoid arthritis from the JointMan database.

Zhuo J, Lama S, Knapp K, Gutierrez C, Lovett K, Thai S, Craig GL.

Sci Rep. 2023 Jul 19;13(1):11678. doi: 10.1038/s41598-023-37452-y.

PMID: 37468565 

 

MYD88L265P Augments Proximal B-Cell Receptor Signaling in Large B-Cell Lymphomas Via an Interaction with DOCK8.

Mandato E, Yan Q, Ouyang J, Paczkowska J, Qin Y, Hao Y, Bojarczuk K, Hansen J, Chapuy B, Rodig SJ, Khan SJ, Redd RA, Shipp MA.

Blood. 2023 Jul 19:blood.2023019865. doi: 10.1182/blood.2023019865. Online ahead of print.

PMID: 37467575

 

Physiologically Based Pharmacokinetic Modeling and Simulation of Mavacamten Exposure with Drug-Drug Interactions from CYP Inducers and Inhibitors by CYP2C19 Phenotype.

Chiang M, Sychterz C, Perera V, Merali S, Palmisano M, Templeton IE, Gaohua L.

Clin Pharmacol Ther. 2023 Jul 19. doi: 10.1002/cpt.3005. Online ahead of print.

PMID: 37467157

 

Stereocontrolled Radical Thiophosphorylation.

Nassir M, Ociepa M, Zhang HJ, Grant LN, Simmons BJ, Oderinde MS, Kawamata Y, Cauley AN, Schmidt MA, Eastgate MD, Baran PS.

J Am Chem Soc. 2023 Jul 19;145(28):15088-15093. doi: 10.1021/jacs.3c05655. Epub 2023 Jul 3.

PMID: 37399078

 

A rank-based approach to improve the efficiency of inferential seamless phase 2/3 clinical trials with dose optimization.

Wang X, Chen M, Chu S, Fan R, Chan ISF.

Contemp Clin Trials. 2023 Jul 17;132:107300. doi: 10.1016/j.cct.2023.107300. Online ahead of print.

PMID: 37467949

 

Unmet Needs in Real-World Advanced Therapy-Naïve and -Experienced Patients with Moderately to Severely Active Ulcerative Colitis in the United States.

Afzali A, Lukanova R, Hennessy F, Kakehi S, Knight H, Milligan G, Gupte-Singh K.

Adv Ther. 2023 Jul 17. doi: 10.1007/s12325-023-02605-y. Online ahead of print.

PMID: 37458875

 

Platform trials to evaluate the benefit-risk of COVID-19 therapeutics: Successes, learnings, and recommendations for future pandemics.

Buenconsejo J, Liao R, Lin J, Singh P, Cooner F, Ghosh S, Gamalo M, Russek-Cohen E, Zariffa N.

Contemp Clin Trials. 2023 Jul 16;132:107292. doi: 10.1016/j.cct.2023.107292. Online ahead of print.

PMID: 37454729 

 

Abatacept as Monotherapy and in Combination with Methotrexate in Patients with Juvenile Idiopathic Arthritis: Analysis of 2 Phase III Trials.

Ruperto N, Lovell DJ, Berman A, Anton J, Viola DO, Lauwerys B, Rama ME, Bohnsack J, Breedt J, Fischbach M, Lutz T, Minden K, Ally M, Rubio-Pérez N, Gervais E, Van Zyl R, Wong R, Askelson M, Martini A, Brunner HI; Pediatric Rheumatology Collaborative Study Group (PRCSG) and the Paediatric Rheumatology INternational Trials Organisation (PRINTO).

J Rheumatol. 2023 Jul 15:jrheum.2022-1320. doi: 10.3899/jrheum.2022-1320. Online ahead of print.

PMID: 37453737

 

Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations.

Xiao Z, Yang MG, Liu C, Sherwood T, Gilmore JL, Lin J, Li P, Wu DR, Tokarski J, Li S, Cheng L, Xie C, Fan J, Dierks E, Strnad J, Cvijic ME, Khan J, Ruzanov M, Galella M, Khandelwal P, Dyckman AJ, Mathur A, Lombardo LJ, Macor JE, Carter PH, Aranibar N, Burke JR, Weinstein DS.

Bioorg Med Chem Lett. 2023 Jul 15;91:129373. doi: 10.1016/j.bmcl.2023.129373. Epub 2023 Jun 12.

PMID: 37315697

 

Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders.

Moore F, Wang W, Zhao G, Mignone J, Meng W, Chu CH, Ma Z, Azzara A, Cullen MJ, Pelleymounter MA, Appiah K, Cvijic ME, Dierks E, Chang S, Foster K, Kopcho L, O'Malley K, Li YX, Khandelwal P, Whaley JM, Mathur A, Hou X, Wu DR, Robl JA, Cheng D, Devasthale P.

Bioorg Med Chem Lett. 2023 Jul 15;91:129362. doi: 10.1016/j.bmcl.2023.129362. Epub 2023 Jun 8.

PMID: 37295614

 

Smarca2 genetic ablation is phenotypically benign in a safety assessment of tamoxifen-inducible conditional knockout rats.

Maher J, Stagg N, Cain G, Andaya R, Katavolos P, Gallardo-Chang F, Pham A, Ye X, Januario T, Alcantar T, Caothien R, Roose-Girma M, Zhang D, Li R, Chen S, Yauch RL.

Toxicol Appl Pharmacol. 2023 Jul 14;475:116627. doi: 10.1016/j.taap.2023.116627. Online ahead of print.

PMID: 37453479 

 

Understanding the Non-Equivalency of Bio-Fluorescent Particle Counts versus the Colony Forming Unit.

Salvas J, Merker P, Dingle M, Joossen C, Knutsen C, Govezensky D, Cannon J, Villari P, Cundell AM, Navarro V, Franz-Riethdorf M, Scott A.

PDA J Pharm Sci Technol. 2023 Jul 14:pdajpst.2022.012790. doi: 10.5731/pdajpst.2022.012790. Online ahead of print.

PMID: 37451837

 

A comprehensive strategy for the identification of biologics by liquid-chromatography-mass spectrometry for release testing in a regulated environment.

Morales A, Candreva J, Jayarathne T, Esterman AL, Voruganti S, Flagg SC, Slaney T, Liu P, Adamo M, Patel S, Das TK, Zeng M, Li X.

J Pharm Biomed Anal. 2023 Jul 13;234:115580. doi: 10.1016/j.jpba.2023.115580. Online ahead of print.

PMID: 37478550

  

Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases.

Reese-Petersen AL, Genovese F, Zhao L, Banks G, Gordon DA, Karsdal MA.

Front Mol Biosci. 2023 Jul 12;10:1228232. doi: 10.3389/fmolb.2023.1228232. eCollection 2023.

PMID: 37503538 

 

Smoking, blood DNA methylation sites and lung cancer risk.

Domingo-Relloso A, Joehanes R, Rodriguez-Hernandez Z, Lahousse L, Haack K, Fallin MD, Herreros-Martinez M, Umans JG, Best LG, Huan T, Liu C, Ma J, Yao C, Jerolon A, Bermudez JD, Cole SA, Rhoades DA, Levy D, Navas-Acien A, Tellez-Plaza M.

Environ Pollut. 2023 Jul 11;334:122153. doi: 10.1016/j.envpol.2023.122153. Online ahead of print.

PMID: 37442331

 

Economic burden during remission and after relapse among older patients with newly diagnosed acute myeloid leukemia without hematopoietic stem cell transplant: A retrospective study using the SEER-Medicare database.

Brunner AM, Huggar D, Copher R, Zhou ZY, Zichlin ML, Anderson A, Downes N, McBride A.

Leuk Res. 2023 Jul 10;132:107353. doi: 10.1016/j.leukres.2023.107353. Online ahead of print.

PMID: 37562330 

 

Genome-Wide Association Study for the Genetic Determinants of Thiopurine Methyltransferase Protein Expression in Human Livers and Racial Differences.

Smith LS, Wang X, Shi J, He B, Zhu HJ.

Pharm Res. 2023 Jul 10. doi: 10.1007/s11095-023-03558-1. Online ahead of print.

PMID: 37430149

 

Phase 4 Multinational Multicenter Retrospective and Prospective Real-World Study of Nivolumab in Recurrent and Metastatic Squamous Cell Carcinoma of the Head and Neck.

Gogate A, Bennett B, Poonja Z, Stewart G, Medina Colmenero A, Szturz P, Carrington C, Castro C, Gemmen E, Lau A, Carral Maseda A, Winquist E, Arrazubi V, Hao D, Cook A, Martinez Galan J, Ugidos L, Fernández Garay D, Gutierrez Abad D, Metcalf R.

Cancers (Basel). 2023 Jul 9;15(14):3552. doi: 10.3390/cancers15143552.

PMID: 37509217 

 

Population Pharmacokinetics of Oral Azacitidine, and Exposure-Response Analysis in Acute Myeloid Leukemia.

Gaudy A, Laille E, Bailey R, Zhou S, Skikne B, Beach CL.

Clin Pharmacol Ther. 2023 Jul 8. doi: 10.1002/cpt.2982. Online ahead of print.

PMID: 37422689

 

Bioanalytical Methods for Characterization of CAR-T Cellular Kinetics: Comparison of PCR Assays and Matrices.

Masilamani M, Jawa V, Dai Y, Das R, Park A, Lamba M, Wu F, Zheng X, Lu E, Gleason C, Mack T, Mora J, Surapaneni S.

Clin Pharmacol Ther. 2023 Jul 8. doi: 10.1002/cpt.2991. Online ahead of print.

PMID: 37422675

 

Neutralizing Antibody Validation Testing and Reporting Harmonization.

Myler H, Pedras-Vasconcelos J, Lester T, Civoli F, Xu W, Wu B, Vainshtein I, Luo L, Hassanein M, Liu S, Ramaswamy SS, Mora J, Pennucci J, McCush F, Lavelle A, Jani D, Ambakhutwala A, Baltrukonis D, Barker B, Carmean R, Chung S, Dai S, DeWall S, Dholakiya SL, Dodge R, Finco D, Yan H, Hays A, Hu Z, Inzano C, Kamen L, Lai CH, Meyer E, Nelson R, Paudel A, Phillips K, Poupart ME, Qu Q, Abhari MR, Ryding J, Sheldon C, Spriggs F, Warrino D, Wu Y, Yang L, Pasas-Farmer S.

AAPS J. 2023 Jul 8;25(4):69. doi: 10.1208/s12248-023-00830-5.

PMID: 37421491

 

Perspectives on Patient-Reported Outcome Data After Treatment Discontinuation in Cancer Clinical Trials.

King-Kallimanis BL, Calvert M, Cella D, Cocks K, Coens C, Fairclough D, Howie L, Jonsson P, Mahendraratnam N, Maues J, Sarac S, Shaw J, Stigger N, Trask P, Wieseler B.

Value Health. 2023 Jul 6:S1098-3015(23)03036-X. doi: 10.1016/j.jval.2023.06.019. Online ahead of print.

PMID: 37422075

 

Trapping mode two-dimensional liquid chromatography for quantitative low-level impurity enrichment in pharmaceutical development.

Lin Z, Wang Q, Zhou Y, Shackman JG.

J Chromatogr A. 2023 Jul 5;1700:464043. doi: 10.1016/j.chroma.2023.464043. Epub 2023 May 3.

PMID: 37172541

 

Factors associated with oral anticoagulant prescription status among patients with a new diagnosis of atrial fibrillation.

Manning E, Burns K, Laurie M, Patten L, Ho M, Sandhu A.

Clin Cardiol. 2023 Jul 4. doi: 10.1002/clc.24077. Online ahead of print.

PMID: 37401357 

 

Interlaboratory Variability in the Madin-Darby Canine Kidney Cell Proteome.

Harwood MD, Zettl K, Weinheimer M, Pilla-Reddy V, Shen H, Jacobs F, Chu X, Huth F, Nakakariya M, Chothe PP, Neuhoff S, Wiśniewski JR.

Mol Pharm. 2023 Jul 3;20(7):3505-3518. doi: 10.1021/acs.molpharmaceut.3c00108. Epub 2023 Jun 7.

PMID: 37283406 

 

Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma.

Apollonio B, Spada F, Petrov N, Cozzetto D, Papazoglou D, Jarvis P, Kannambath S, Terranova-Barberio M, Amini RM, Enblad G, Graham C, Benjamin R, Phillips E, Ellis R, Nuamah R, Saqi M, Calado DP, Rosenquist R, Sutton LA, Salisbury J, Zacharioudakis G, Vardi A, Hagner PR, Gandhi AK, Bacac M, Claus C, Umana P, Jarrett RF, Klein C, Deutsch A, Ramsay AG.

J Clin Invest. 2023 Jul 3;133(13):e166070. doi: 10.1172/JCI166070.

PMID: 37219943 

Best Practices and Considerations for Clinical Pharmacology and Pharmacometric Aspects for Optimal Development of CAR-T and TCR-T Cell Therapies: An Industry Perspective.

Mody H, Ogasawara K, Zhu X, Miles D, Shastri PN, Gokemeijer J, Liao MZ, Kasichayanula S, Yang TY, Chemuturi N, Gupta S, Jawa V, Upreti VV.

Clin Pharmacol Ther. 2023 Jul 2. doi: 10.1002/cpt.2986. Online ahead of print.

PMID: 37393588 

 

Harmonization of criteria and terminology in fetal rat skeletal evaluations.

Posobiec LM, Kopp C, Murzyn SM, Olitan T, Rendemonti J, French J, Tamborini E, Campey J, Longo M, Danberry T, Vaillancourt M, Nowland W, Daoud M, Qualls C, Harris SB.

Birth Defects Res. 2023 Jul 1;115(12):1109-1119. doi: 10.1002/bdr2.2189. Epub 2023 May 26.

PMID: 37243321

 

γ-Secretase inhibitor in combination with BCMA chimeric antigen receptor T-cell immunotherapy for individuals with relapsed or refractory multiple myeloma: a phase 1, first-in-human trial.

Cowan AJ, Pont MJ, Sather BD, Turtle CJ, Till BG, Libby EN 3rd, Coffey DG, Tuazon SA, Wood B, Gooley T, Wu VQ, Voutsinas J, Song X, Shadman M, Gauthier J, Chapuis AG, Milano F, Maloney DG, Riddell SR, Green DJ.

Lancet Oncol. 2023 Jul;24(7):811-822. doi: 10.1016/S1470-2045(23)00246-2.

PMID: 37414012 

 

Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial.

Hunger SP, Tran TH, Saha V, Devidas M, Valsecchi MG, Gastier-Foster JM, Cazzaniga G, Reshmi SC, Borowitz MJ, Moorman AV, Heerema NA, Carroll AJ, Martin-Regueira P, Loh ML, Raetz EA, Schultz KR, Slayton WB, Cario G, Schrappe M, Silverman LB, Biondi A.

Lancet Haematol. 2023 Jul;10(7):e510-e520. doi: 10.1016/S2352-3026(23)00088-1.

PMID: 37407142 

 

Erratum to High Interobserver Variability Among Pathologists Using Combined Positive Score to Evaluate PD-L1 Expression in Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma [Modern Pathology 36(5) (2023) 100154].

Robert ME, Rüschoff J, Jasani B, Graham RP, Badve SS, Rodriguez-Justo M, Kodach LL, Srivastava A, Wang HL, Tang LH, Troncone G, Rojo F, Van Treeck BJ, Pratt J, Shnitsar I, Kumar G, Karasarides M, Anders RA.

Mod Pathol. 2023 Jul;36(7):100238. doi: 10.1016/j.modpat.2023.100238. Epub 2023 Jun 14.

PMID: 37327723  

 

HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin.

Muretta JM, Rajasekaran D, Blat Y, Little S, Myers M, Nair C, Burdekin B, Yuen SL, Jimenez N, Guhathakurta P, Wilson A, Thompson AR, Surti N, Connors D, Chase P, Harden D, Barbieri CM, Adam L, Thomas DD.

SLAS Discov. 2023 Jul;28(5):223-232. doi: 10.1016/j.slasd.2023.06.001. Epub 2023 Jun 10.

PMID: 37307989 

   

Lipidation of a bioactive cyclotide-based CXCR4 antagonist greatly improves its pharmacokinetic profile in vivo.

Chaudhuri D, Lu T, Jacob B, Abraham S, Shankar P, Poss MA, Neamati N, Camarero JA.

J Control Release. 2023 Jul;359:26-32. doi: 10.1016/j.jconrel.2023.05.026. Epub 2023 May 30.

PMID: 37236320

 

Statistical Considerations on the Use of RWD/RWE for Oncology Drug Approvals: Overview and Lessons Learned.

Ro SK, Zhang W, Jiang Q, Li XN, Liu R, Lu CC, Marchenko O, Sun L, Zhao J.

Ther Innov Regul Sci. 2023 Jul;57(4):899-910. doi: 10.1007/s43441-023-00528-y. Epub 2023 May 13.

PMID: 37179264  

 

Health-related quality of life with nivolumab plus relatlimab versus nivolumab monotherapy in patients with previously untreated unresectable or metastatic melanoma: RELATIVITY-047 trial.

Schadendorf D, Tawbi H, Lipson EJ, Stephen Hodi F, Rutkowski P, Gogas H, Lao CD, Grob JJ, Moshyk A, Lord-Bessen J, Hamilton M, Guo S, Shi L, Keidel S, Long GV.

Eur J Cancer. 2023 Jul;187:164-173. doi: 10.1016/j.ejca.2023.03.014. Epub 2023 Mar 22.

PMID: 37167764  

 

Technical considerations for the implementation of the multi-attribute-method by mass spectrometry in a quality control laboratory.

Pohl T, Gervais A, Dirksen EHC, D'Alessio V, Bechtold-Peters K, Burkitt W, Cao L, Greven S, Lennard A, Li X, Lössner C, Niu B, Reusch D, O'Riordan T, Shearer JW, Spencer D, Xu W, Yi L.

Eur J Pharm Biopharm. 2023 Jul;188:231-242. doi: 10.1016/j.ejpb.2023.04.024. Epub 2023 May 3.

PMID: 37146738

 

Cost-Effectiveness of Nivolumab Plus Ipilimumab for the First-Line Treatment of Intermediate/Poor-Risk Advanced and/or Metastatic Renal Cell Carcinoma in Switzerland.

Çakar E, Oniangue-Ndza C, Schneider RP, Klijn SL, Vogl UM, Rothermundt C, May JR.

Pharmacoecon Open. 2023 Jul;7(4):567-577. doi: 10.1007/s41669-023-00395-1. Epub 2023 Feb 9.

PMID: 36757568 

 

Malignancy outcomes in patients with rheumatoid arthritis treated with abatacept and other disease-modifying antirheumatic drugs: Results from a 10-year international post-marketing study.

Simon TA, Suissa S, Boers M, Hochberg MC, Skovron ML, Askling J, Michaud K, Strangfeld A, Pedro S, Frisell T, Meissner Y, Dominique A, Gomez A.

Semin Arthritis Rheum. 2023 Jun 30:152240. doi: 10.1016/j.semarthrit.2023.152240. Online ahead of print.

PMID: 37500379 

 

Medical Needs and Therapeutic Options for Melanoma Patients Resistant to Anti-PD-1-Directed Immune Checkpoint Inhibition.

Hassel JC, Zimmer L, Sickmann T, Eigentler TK, Meier F, Mohr P, Pukrop T, Roesch A, Vordermark D, Wendl C, Gutzmer R.

Cancers (Basel). 2023 Jun 30;15(13):3448. doi: 10.3390/cancers15133448.

PMID: 37444558  

 

SpatialSort: a Bayesian model for clustering and cell population annotation of spatial proteomics data.

Lee E, Chern K, Nissen M, Wang X; IMAXT Consortium; Huang C, Gandhi AK, Bouchard-Côté A, Weng AP, Roth A.

Bioinformatics. 2023 Jun 30;39(39 Suppl 1):i131-i139. doi: 10.1093/bioinformatics/btad242.

PMID: 37387130 

 

Treatment patterns and outcomes of patients with metastatic non-small cell lung cancer in five European countries: a real-world evidence survey.

Bailey H, Lee A, Eccles L, Yuan Y, Burlison H, Forshaw C, Varol N.

BMC Cancer. 2023 Jun 30;23(1):603. doi: 10.1186/s12885-023-11074-z.

PMID: 37386452 

 

External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real World Data Sources.

Swaminathan AC, Snyder LD, Hong H, Stevens SR, Long AS, Yanchenko E, Qiu Y, Liu R, Zhang H, Fischer A, Burns L, Wruck LM, Palmer SM.

Am J Respir Crit Care Med. 2023 Jun 29. doi: 10.1164/rccm.202210-1947OC. Online ahead of print.

PMID: 37384378

 

A quantitative assessment of deformation energy in intermolecular interactions: How important is it?

Sargent CT, Kasera R, Glick ZL, Sherrill CD, Cheney DL.

J Chem Phys. 2023 Jun 28;158(24):244106. doi: 10.1063/5.0155895.

PMID: 37352421

 

Drug-Drug Interaction Potential of Mavacamten with Oral Contraceptives: Results from a Clinical Pharmacokinetic Study and a Physiologically Based Pharmacokinetic Model.

Chiang M, Sychterz C, Gaohua L, Perera V, Gretler DD, Florea V, Merali S.

J Clin Pharmacol. 2023 Jun 27. doi: 10.1002/jcph.2298. Online ahead of print.

PMID: 37376778

 

Beyond Amide Bond Formation: TCFH as a Reagent for Esterification.

Luis NR, Chung KK, Hickey MR, Lin Z, Beutner GL, Vosburg DA.

Org Lett. 2023 Jun 26. doi: 10.1021/acs.orglett.3c01611. Online ahead of print.

PMID: 37364890

 

Nivolumab combined with brentuximab vedotin for R/R primary mediastinal large B-cell lymphoma: a 3-year follow-up.

Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Lisano JM, Wen R, Akyol A, Moskowitz AJ.

Blood Adv. 2023 Jun 23:bloodadvances.2023010254. doi: 10.1182/bloodadvances.2023010254. Online ahead of print.

PMID: 37352266

 

Perception of Nursing Activities That Contribute to the Quality of Care: Validity and Reliability Testing of the French Version.

Estefania C, Silvia FC, Rosa L, Teresa M, Narcisa GM, Manuela MM.

J Nurs Meas. 2023 Jun 22:JNM-2022-0090.R1. doi: 10.1891/JNM-2022-0090. Online ahead of print.

PMID: 37348891

Postmarketing surveillance of nivolumab plus ipilimumab combination therapy in Japanese patients with unresectable malignant melanoma.

Yamazaki N, Kiyohara Y, Uhara H, Tsuchida T, Yoshida A, Yamada T, Komoto A.

J Dermatol. 2023 Jun 22. doi: 10.1111/1346-8138.16820. Online ahead of print.

PMID: 37350027

 

Metallaphotoredox-Mediated Decarboxylative Cross-Coupling of α-Oxy Morpholine Carboxylic Acids and (Hetero)Aryl Halides.

Sloane JL, Santos AB, Simmons EM, Sherwood TC.

Org Lett. 2023 Jun 16;25(23):4219-4224. doi: 10.1021/acs.orglett.3c01478. Epub 2023 Jun 6.

PMID: 37279441

 

Streamlining Food Effect Assessment - Are Repeated Food Effect Studies Needed? An IQ Analysis.

Kesisoglou F, Basu S, Belubbi T, Bransford P, Chung J, Dodd S, Dolton M, Heimbach T, Kulkarni P, Lin W, Moir A, Parrott N, Pepin X, Ren X, Sharma P, Stamatopoulos K, Tistaert C, Vaidhyanathan S, Wagner C, Riedmaier AE.

AAPS J. 2023 Jun 15;25(4):60. doi: 10.1208/s12248-023-00822-5.

PMID: 37322223

 

The implementation of value-based frameworks, clinical care pathways, and alternative payment models for cancer care in the United States.

Panchal R, Brendle M, Ilham S, Kharat A, Schmutz HW, Huggar D, McBride A, Copher R, Au T, Willis C, Brixner D.

J Manag Care Spec Pharm. 2023 Jun 15:1-10. doi: 10.18553/jmcp.2023.22352. Online ahead of print.

PMID: 37321967

 

Data-driven strategies for increasing patient diversity in Bristol Myers Squibb-sponsored US oncology clinical trials.

Kuri L, Setru S, Liu G, Reed DM, Weigand D, Surampudi A, Berger S, Paulucci D, Rai A, Sethuraman V, Vito B, Kellar-Wood H, Balan MM.

Clin Trials. 2023 Jun 13:17407745231180506. doi: 10.1177/17407745231180506. Online ahead of print.

PMID: 37309819

 

Safety outcomes in patients with rheumatoid arthritis treated with abatacept: results from a multinational surveillance study across seven European registries.

Dominique A, Hetland ML, Finckh A, Gottenberg JE, Iannone F, Caporali R, Kou TD, Nordstrom D, Hernandez MV, Sánchez-Piedra C, Sánchez-Alonso F, Pavelka K, Bond TC, Simon TA.

Arthritis Res Ther. 2023 Jun 12;25(1):101. doi: 10.1186/s13075-023-03067-x.

PMID: 37308978 

 

Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization.

Chupak L, Wichroski M, Zheng X, Ding M, Martin S, Allard C, Shi J, Gentles R, Meanwell NA, Fang J, Tenney D, Tokarski J, Cao C, Wee S.

ACS Med Chem Lett. 2023 Jun 12;14(7):929-935. doi: 10.1021/acsmedchemlett.3c00063. eCollection 2023 Jul 13.

PMID: 37465293

 

A Real-World Evaluation of Primary Medication Nonadherence in Patients with Nonvalvular Atrial Fibrillation Prescribed Oral Anticoagulants in the United States.

Hernandez I, Divino V, Xie L, Hood DW, DeKoven M, Kariuki W, Bell G, Russ C, Cheng D, Cato M, Atreja N, Hines DM.

Am J Cardiovasc Drugs. 2023 Jun 10. doi: 10.1007/s40256-023-00588-3. Online ahead of print.

PMID: 37301789

Identification and validation of G protein-coupled receptors modulating flow-dependent signaling pathways in vascular endothelial cells.

Qiu D, Xu K, Chung N, Robbins J, Luo R, Lawrence M, He A, Yu F, Alt A, Miller MM, Hangeland J, Feder JN, Seiffert D, Arey BJ.

Front Mol Biosci. 2023 Jun 8;10:1198079. doi: 10.3389/fmolb.2023.1198079. eCollection 2023.

PMID: 37363403

 

Correction: Harmonizing Biopredictive Methodologies Through the Product Quality Research Institute (PQRI) Part I: Biopredictive Dissolution of Ibuprofen and Dipyridamole Tablets.

Tsume Y, Ashworth L, Bermejo M, Cheng J, Cicale V, Dressman J, Fushimi M, Gonzalez-Alvarez I, Guo Y, Jankovsky C, Lu X, Matsui K, Patel S, Sanderson N, Sun CC, Thakral NK, Yamane M, Zöller L.

AAPS J. 2023 Jun 8;25(4):58. doi: 10.1208/s12248-023-00827-0.

PMID: 37291273 

 

Medicaid coverage practices for approved gene and cell therapies: Existing barriers and proposed policy solutions.

Allen J, Berry D, Cook F, Hume A, Rouce R, Srirangam A, Wellman J, McCombs C.

Mol Ther Methods Clin Dev. 2023 May 16;29:513-521. doi: 10.1016/j.omtm.2023.05.015. eCollection 2023 Jun 8.

PMID: 37287748  

 

Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.

Hartz RA, Ahuja VT, Luo G, Chen L, Sivaprakasam P, Xiao H, Krause CM, Clarke WJ, Xu S, Tokarski JS, Kish K, Lewis H, Szapiel N, Ravirala R, Mutalik S, Nakmode D, Shah D, Burton CR, Macor JE, Dubowchik GM.

J Med Chem. 2023 Jun 8;66(11):7534-7552. doi: 10.1021/acs.jmedchem.3c00364. Epub 2023 May 26.

PMID: 37235865

 

Predictors of Lenalidomide Refractory Relapse Timing With Newly Diagnosed Multiple Myeloma: A FIRST Trial Subanalysis.

Manier S, Dimopoulos M, Hulin C, Leleu X, Delforge M, Weisel K, Mouro J, Costa B, Sturniolo M, Facon T.

Clin Lymphoma Myeloma Leuk. 2023 Jun 7:S2152-2650(23)00183-0. doi: 10.1016/j.clml.2023.06.002. Online ahead of print.

PMID: 37393121

 

Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes.

Mandler MD, Mignone J, Jurica EA, Palkowitz MD, Aulakh D, Cauley AN, Farley CA, Zhang S, Traeger SC, Sarjeant A, Paiva A, Perez HL, Ellsworth BA, Regueiro-Ren A.

Org Lett. 2023 Jun 7. doi: 10.1021/acs.orglett.3c01417. Online ahead of print.

PMID: 37284784

 

Screening Clones for Monoclonal Antibody Production Using Droplet Microfluidics Interfaced to Electrospray Ionization Mass Spectrometry.

D'Amico CI, Robbins G, Po I, Fang Z, Slaney TR, Tremml G, Tao L, Ruotolo BT, Kennedy RT.

J Am Soc Mass Spectrom. 2023 Jun 7;34(6):1117-1124. doi: 10.1021/jasms.3c00055. Epub 2023 May 16.

PMID: 37192521

 

Lisocabtagene maraleucel in chronic lymphocytic leukaemia and small lymphocytic lymphoma (TRANSCEND CLL 004): a multicentre, open-label, single-arm, phase 1-2 study.

Siddiqi T, Maloney DG, Kenderian SS, Brander DM, Dorritie K, Soumerai J, Riedell PA, Shah NN, Nath R, Fakhri B, Stephens DM, Ma S, Feldman T, Solomon SR, Schuster SJ, Perna SK, Tuazon SA, Ou SS, Papp E, Peiser L, Chen Y, Wierda WG.

Lancet. 2023 Jun 5:S0140-6736(23)01052-8. doi: 10.1016/S0140-6736(23)01052-8. Online ahead of print.

PMID: 37295445

 

Activation-inducible CAR expression enables precise control over engineered CAR T cell function.

Fraessle SP, Tschulik C, Effenberger M, Cletiu V, Gerget M, Schober K, Busch DH, Germeroth L, Stemberger C, Poltorak MP.

Commun Biol. 2023 Jun 5;6(1):604. doi: 10.1038/s42003-023-04978-w.

PMID: 37277433 

 

Cellular Composition and 5hmC Signature Predict the Treatment Response of AML Patients to Azacitidine Combined with Chemotherapy.

Liang G, Wang L, You Q, Cahill K, Chen C, Zhang W, Fulton N, Stock W, Odenike O, He C, Han D.

Adv Sci (Weinh). 2023 Jun 4:e2300445. doi: 10.1002/advs.202300445. Online ahead of print.

PMID: 37271891

 

Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.

Dzierba CD, Dasgupta B, Karageorge G, Kostich W, Hamman B, Allen J, Esposito KM, Padmanabha R, Grace J, Lentz K, Morrison J, Morgan D, Easton A, Bourin C, Browning MR, Rajamani R, Good A, Parker DD, Muckelbauer JK, Khan J, Camac D, Ghosh K, Halan V, Lippy JS, Santone KS, Denton RR, Westphal R, Bristow LJ, Conway CM, Bronson JJ, Macor JE.

Med Chem Res. 2023 Jun 3:1-7. doi: 10.1007/s00044-023-03079-x. Online ahead of print.

PMID: 37362320 

 

Survey Outcome on Immunogenicity Risk Assessment Tools for Biotherapeutics: an Insight into Consensus on Methods, Application, and Utility in Drug Development.

Gokemeijer J, Wen Y, Jawa V, Mitra-Kaushik S, Chung S, Goggins A, Kumar S, Lamberth K, Liao K, Lill J, Phung Q, Walsh R, Roberts BJ, Swanson M, Singh I, Tourdot S, Kroenke MA, Rup B, Goletz TJ, Gupta S, Malherbe L, Pattijn S.

AAPS J. 2023 Jun 2;25(4):55. doi: 10.1208/s12248-023-00820-7.

PMID: 37266912

 

Examining the Scope of Deriving β-Aryl Enones from Enol Silanes as Ketone Equivalents via Pd(II)-Mediated Sequential Dehydrosilylation and Arylation.

Polimera SR, Ilangovan A, Subbaiah MAM.

J Org Chem. 2023 Jun 2;88(11):7256-7271. doi: 10.1021/acs.joc.3c00502. Epub 2023 May 16.

PMID: 37192466

 

Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer.

Barrera C, Corredor G, Viswanathan VS, Ding R, Toro P, Fu P, Buzzy C, Lu C, Velu P, Zens P, Berezowska S, Belete M, Balli D, Chang H, Baxi V, Syrigos K, Rimm DL, Velcheti V, Schalper K, Romero E, Madabhushi A.

NPJ Precis Oncol. 2023 Jun 1;7(1):52. doi: 10.1038/s41698-023-00403-x.

PMID: 37264091 

 

Enabling Efficient Design of Biological Formulations through Advanced Characterizations.

Chen K, Cheung JK, Kim HA, Leone A, Mallela K, Su Y.

Pharm Res. 2023 Jun;40(6):1313-1316. doi: 10.1007/s11095-023-03557-2.

PMID: 37407877 

 

Exceptional Response to Bromodomain and Extraterminal Domain Inhibitor Therapy With BMS-986158 in BRD4-NUTM1 NUT Carcinoma Harboring a BRD4 Splice Site Mutation.

Cheng ML, Huang Y, Luong N, LoPiccolo J, Nishino M, Sholl LM, Chirieac LR, Santucci AD, Rabin MS, Jänne PA, Coker S, Diamond JR, Hilton J, Shapiro GI, French CA.

JCO Precis Oncol. 2023 Jun;7:e2200633. doi: 10.1200/PO.22.00633.

PMID: 37384867 

 

Analysis of Cancer Research Projects in Sub-Saharan Africa: A Quantitative Perspective on Unmet Needs and Opportunities.

Davies L, Milner DA Jr, Shulman LN, Kyokunda L, Bedada A, Vuylsteke P, Masalu N, Jackson P, Jennings N, Odunlami A, Mtshali P, Dugan U.

JCO Glob Oncol. 2023 Jun;9:e2200203. doi: 10.1200/GO.22.00203.

PMID: 37290022

  

Suboptimal Clinical and Quality of Life Outcomes in Patients with Psoriasis Undertreated with Oral Therapies: International Physician and Patient Survey.

Thai S, Barlow S, Lucas J, Piercy J, Zhong Y, Zhuo J, Wu JJ.

Dermatol Ther (Heidelb). 2023 Jun;13(6):1289-1303. doi: 10.1007/s13555-023-00927-x. Epub 2023 May 31.

PMID: 37253874 

 

General population reference values for the Functional Assessment of Cancer Therapy-Lung and PROMIS-29.

Mohindra NA, Peipert JD, Blum SI, Shaw JW, Penrod JR, Cella D.

Cancer Med. 2023 Jun;12(11):12765-12776. doi: 10.1002/cam4.5920. Epub 2023 May 6.

PMID: 37148552 

 

Safety and Effectiveness of Vedolizumab in Patients with Moderate-to-Severe Ulcerative Colitis: An Interim Analysis of a Japanese Post-Marketing Surveillance Study.

Matsuoka K, Hisamatsu T, Mikami Y, Yamamoto T, Motoya S, Shinzaki S, Iwakiri R, Sugiura K, Nishimura K, Kajita M, Fernandez JL.

Adv Ther. 2023 Jun;40(6):2902-2914. doi: 10.1007/s12325-023-02500-6. Epub 2023 May 4.

PMID: 37140705 

 

Quantifying The Burden of Persistent Musculoskeletal Pain in Employees at Rolls-Royce in The United Kingdom: A Real-World Cross-Sectional Survey.

Abraham L, Russell R, Sanchez-Riera L, Emir B, Roomes D, Green K, Taylor-Stokes G, Mirams L, Wallis H, Burton K.

J Occup Environ Med. 2023 Jun 1;65(6):e424-e434. doi: 10.1097/JOM.0000000000002845. Epub 2023 Mar 25.

PMID: 36977358 

 

Predictors of 30-day readmission, mortality, and length of stay for hospitalized U.S. patients with Alzheimer's and related dementias from 2010 to 2015.

Sanogo V, Chen Z, Almutairi RD, Hong X, Diaby V.

Expert Rev Pharmacoecon Outcomes Res. 2023 Jun;23(5):555-559. doi: 10.1080/14737167.2023.2195628. Epub 2023 Mar 29.

PMID: 36974630

 

Sustained Remission and Outcomes with Abatacept plus Methotrexate Following Stepwise Dose De-escalation in Patients with Early Rheumatoid Arthritis.

Emery P, Tanaka Y, Bykerk VP, Huizinga TWJ, ra G, Bingham CO 3rd, Banerjee S, Soule BP, Nys M, Connolly SE, Lozenski KL, Zhuo J, Wong R, Huang KG, Fleischmann R.

Rheumatol Ther. 2023 Jun;10(3):707-727. doi: 10.1007/s40744-022-00519-9. Epub 2023 Mar 3.

PMID: 36869251 

 

Peripheral Blood Monocytosis Is Associated With Long-Term Disease Severity in Pediatric-Onset Inflammatory Bowel Disease.

Zhang X, Ramos-Rivers C, Prathapan K, Wang X, Tang G, Kim S, Binion DG.

J Pediatr Gastroenterol Nutr. 2023 Jun 1;76(6):756-762. doi: 10.1097/MPG.0000000000003755. Epub 2023 Feb 23.

PMID: 36827967

 

Comparative Effectiveness of Abatacept vs. Tofacitinib in Rheumatoid Arthritis Patients who are CCP.

Harrold LR, Wittstock K, Kelly S, Han X, Shan Y, Guo L, Moore PC, Khaychuk V.

Rheumatol Ther. 2023 Jun;10(3):575-587. doi: 10.1007/s40744-022-00523-z. Epub 2023 Feb 7.

PMID: 36749478 

 

Minimal residual disease predicts outcomes in KMT2A-rearranged but not KMT2A-germline infant acute lymphoblastic leukemia: Report from Children's Oncology Group study AALL0631.

Faulk KE, Kairalla JA, Dreyer ZE, Carroll AJ, Heerema NA, Devidas M, Carroll WL, Raetz EA, Loh ML, Hunger SP, Borowitz M, Wang C, Guest E, Brown PA.

Pediatr Blood Cancer. 2023 May 31:e30467. doi: 10.1002/pbc.30467. Online ahead of print.

PMID: 37259259

 

Children's Oncology Group AALL1331: Phase III Trial of Blinatumomab in Children, Adolescents, and Young Adults With Low-Risk B-Cell ALL in First Relapse.

Hogan LE, Brown PA, Ji L, Xu X, Devidas M, Bhatla T, Borowitz MJ, Raetz EA, Carroll A, Heerema NA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Hunger SP, Loh ML.

J Clin Oncol. 2023 May 31:JCO2202200. doi: 10.1200/JCO.22.02200. Online ahead of print.

PMID: 37257143

 

Survival outcomes among patients with multiple myeloma in the era of novel agents: exploratory assessment using an electronic medical record database in Japan.

Uno S, Midorikawa S, Inoue K, Ichikawa D, Ito T, Kuroda J, Suzuki K.

PLoS One. 2023 May 31;18(5):e0285947. doi: 10.1371/journal.pone.0285947. eCollection 2023.

PMID: 37256880 

 

Measurement of Moisture Content in Pharmaceutical Tablets by Handheld Near-Infrared Spectrometer: Adopting Quality by Design Approach to Analytical Method Lifecycle Management.

Patel A, Jin C, Handzo B, Kalyanaraman R.

J Pharm Biomed Anal. 2023 May 30;229:115381. doi: 10.1016/j.jpba.2023.115381. Epub 2023 Apr 5.

PMID: 37058983

 

Real-world effectiveness of nivolumab and subsequent therapy in Japanese patients with metastatic renal cell carcinoma (POST-NIVO study): 36-month follow-up results of a clinical chart

Yonese J, Hinata N, Masui S, Nakai Y, Shirotake S, Takeuchi A, Inamoto T, Nozawa M, Ueda K, Etsunaga T, Osawa T, Uemura M, Kimura G, Numakura K, Yamana K, Miyake H, Fukasawa S, Morishima N, Ito H, Uemura H.

Int J Urol. 2023 May 29. doi: 10.1111/iju.15206. Online ahead of print.

PMID: 37248753

 

Treatment-free remission after dasatinib in patients with chronic myeloid leukaemia in chronic phase with deep molecular response: Final 5-year analysis of DASFREE.

Shah NP, García-Gutiérrez V, Jiménez-Velasco A, Larson SM, Saussele S, Rea D, Mahon FX, Levy MY, Gómez-Casares MT, Mauro MJ, Sy O, Martin-Regueira P, Lipton JH.

Br J Haematol. 2023 May 29. doi: 10.1111/bjh.18883. Online ahead of print.

PMID: 37246588

 

MRI Features and Their Association With Outcomes in Children With Anti-NMDA Receptor Encephalitis.

Gombolay G, Brenton JN, Yang JH, Stredny CM, Kammeyer R, Otten CE, Vu N, Santoro JD, Robles-Lopez K, Christiana A, Steriade C, Morris M, Gorman M, Moodley M, Hardy D, Kornbluh AB, Kahn I, Sepeta LN, Yeshokumar A; Conquering Neuroinflammation and Epilepsies Consortium (CONNECT).

Neurol Neuroimmunol Neuroinflamm. 2023 May 26;10(4):e200130. doi: 10.1212/NXI.0000000000200130. Print 2023 Jul.

PMID: 37236807 

 

Associations of disease duration and anti-citrullinated peptide antibody status with the effectiveness of abatacept in biologic-naïve patients with rheumatoid arthritis: Post-hoc analysis of a multicentre, real-world observational study in Japan (ORIGAMI).

Misaki K, Tamura N, Azuma T, Shinoda K, Tanaka M, Fujiwara H, Tsuboi H, Kasama T, Yoshimi R, Hanyu T, Kusaka Y, Hirao M, Onishi M, Uchino A, Izumiyama T, Yang KS, Ogawa N, Matsui K, Kurasawa K, Kawai S, Yasuoka H, Okumura N, Ueda Y, Tanaka E, Inoue E, Tsuritani K, Matsumoto S, Yamanaka H, Harigai M.

Mod Rheumatol. 2023 May 26:road045. doi: 10.1093/mr/road045. Online ahead of print.

PMID: 37233722

 

A review of HTA guidelines on societal and novel value elements.

Breslau RM, Cohen JT, Diaz J, Malcolm B, Neumann PJ.

Int J Technol Assess Health Care. 2023 May 25;39(1):e31. doi: 10.1017/S026646232300017X.

PMID: 37226807 

 

Long-Term Maintenance of Clinical Responses by Individual Patients With Polyarticular-Course Juvenile Idiopathic Arthritis Treated With Abatacept.

Brunner HI, Tzaribachev N, Louw I, Calvo Penades I, Avila-Zapata F, Horneff G, Foeldvari I, Kingsbury DJ, Paz Gastanaga ME, Wouters C, Breedt J, Wong R, Askelson M, Zhuo J, Martini A, Lovell DJ, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG) investigators.

Arthritis Care Res (Hoboken). 2023 May 23. doi: 10.1002/acr.25156. Online ahead of print.

PMID: 37221146

 

Adaptively leveraging external data with robust meta-analytical-predictive prior using empirical Bayes.

Zhang H, Shen Y, Li J, Ye H, Chiang AY.

Pharm Stat. 2023 May 23. doi: 10.1002/pst.2315. Online ahead of print.

PMID: 37220997

 

Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles.

Wang N, Lan C, Lu H, Li L, Liao D, Xu K, Sun H, Tang Y, Wang Y, Mei J, Wei M, Wu T, Zhu H.

PLoS One. 2023 May 19;18(5):e0285216. doi: 10.1371/journal.pone.0285216. eCollection 2023.

PMID: 37205684 

 

Clinical Benefit From Immunotherapy in Patients With SCLC Is Associated With Tumor Capacity for Antigen Presentation.

Rudin CM, Balli D, Lai WV, Richards AL, Nguyen E, Egger JV, Choudhury NJ, Sen T, Chow A, Poirier JT, Geese WJ, Hellmann MD, Forslund A.

J Thorac Oncol. 2023 May 18:S1556-0864(23)00554-3. doi: 10.1016/j.jtho.2023.05.008. Online ahead of print.

PMID: 37210008

 

Understanding preclinical and clinical immunogenicity risks in novel biotherapeutics development.

Sauna ZE, Jawa V, Balu-Iyer S, Chirmule N.

Front Immunol. 2023 May 12;14:1151888. doi: 10.3389/fimmu.2023.1151888. eCollection 2023.

PMID: 37251396 

 

Shallow shotgun sequencing reduces technical variation in microbiome analysis.

La Reau AJ, Strom NB, Filvaroff E, Mavrommatis K, Ward TL, Knights D.

Sci Rep. 2023 May 11;13(1):7668. doi: 10.1038/s41598-023-33489-1.

PMID: 37169816 

 

Exposure-response analysis for nivolumab plus ipilimumab combination therapy in patients with advanced hepatocellular carcinoma (CheckMate 040).

Sangro B, Yau T, El-Khoueiry AB, Kudo M, Shen Y, Tschaika M, Roy A, Feng Y, Gao L, Aras U.

Clin Transl Sci. 2023 May 11. doi: 10.1111/cts.13544. Online ahead of print.

PMID: 37165980

 

Cabozantinib plus Nivolumab and Ipilimumab in Renal-Cell Carcinoma.

Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators.

N Engl J Med. 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851.

PMID: 37163623 

 

Engineering protein A ligands to mitigate antibody loss during high-pH washes in protein A chromatography.

Bhoyar S, Foster M, Oh YH, Xu X, Traylor SJ, Guo J, Ghose S, Lenhoff AM.

J Chromatogr A. 2023 May 10;1696:463962. doi: 10.1016/j.chroma.2023.463962. Epub 2023 Apr 3.

PMID: 37043977

 

HIV and AIDS prevention: knowledge, attitudes, practices and health literacy of older persons in the Western Cape and KwaZulu-Natal Provinces, South Africa and in Lesotho.

Kalula SZ, Blouws T, Ramathebane M, Sayed AR.

BMC Geriatr. 2023 May 8;23(1):279. doi: 10.1186/s12877-023-04009-7.

PMID: 37158837 

 

Investigation of Unusual N-(Triphenyl-λ⁵-phosphanylidene) Amide Fragmentation Observed upon MS/MS Collision-Induced Dissociation.

Kurmi M, Kadambar VK, Srinivas P, Reddi Y, Panda M, Peddicord M, Miller SA, Young J, Bhutani H, Bajpai L.

J Am Soc Mass Spectrom. 2023 May 3;34(5):969-976. doi: 10.1021/jasms.3c00051. Epub 2023 Apr 5.

PMID: 37018737

 

Correlation between pathologic complete response, event-free survival/disease-free survival and overall survival in neoadjuvant and/or adjuvant HR+/HER2-breast cancer.

Gogate A, Ranjan S, Kumar A, Bhandari H, Papademetriou E, Kim I, Potluri R.

Front Oncol. 2023 May 2;13:1119102. doi: 10.3389/fonc.2023.1119102. eCollection 2023.

PMID: 37205193 

 

Ion Mobility-Mass Spectrometry and Collision-Induced Unfolding of Designed Bispecific Antibody Therapeutics.

Villafuerte-Vega RC, Li HW, Slaney TR, Chennamsetty N, Chen G, Tao L, Ruotolo BT.

Anal Chem. 2023 May 2;95(17):6962-6970. doi: 10.1021/acs.analchem.3c00344. Epub 2023 Apr 17.

PMID: 37067470

  

Small-Area Analysis of Treatment and Clinical Outcomes in Patients with Venous Thromboembolism in Denmark: A Nationwide Cohort Study.

Johnsen SP, Jensen M, Münster AM, Frost L, Harboe L, Poulsen PB, Albertsen IE, Vinter N, Grove EL, Larsen TB.

Thromb Haemost. 2023 May 1. doi: 10.1055/a-2073-4336. Online ahead of print.

PMID: 37054981

 

A Gene Panel Associated With Abemaciclib Utility in ESR1-Mutated Breast Cancer After Prior Cyclin-Dependent Kinase 4/6-Inhibitor Progression.

Brett JO, Dubash TD, Johnson GN, Niemierko A, Mariotti V, Kim LSL, Xi J, Pandey A, Dunne S, Nasrazadani A, Lloyd MR, Kambadakone A, Spring LM, Micalizzi DS, Onozato ML, Che D, Nayar U, Brufsky A, Kalinsky K, Ma CX, O'Shaughnessy J, Han HS, Iafrate AJ, Ryan LY, Juric D, Moy B, Ellisen LW, Maheswaran S, Wagle N, Haber DA, Bardia A, Wander SA.

JCO Precis Oncol. 2023 May;7:e2200532. doi: 10.1200/PO.22.00532.

PMID: 37141550

 

Addressing resistance to PD-1/PD-(L)1 pathway inhibition: considerations for combinatorial clinical trial designs.

Zhang T, Forde PM, Sullivan RJ, Sharon E, Barksdale E, Selig W, Ebbinghaus S, Fusaro G, Gunenc D, Battle D, Burns R, Hurlbert MS, Stewart M, Atkins MB.

J Immunother Cancer. 2023 May;11(5):e006555. doi: 10.1136/jitc-2022-006555.

PMID: 37137552 

 

Efficacy and safety of the selective TYK2 inhibitor, deucravacitinib, in Japanese patients with moderate to severe plaque psoriasis: Subgroup analysis of a randomized, double-blind, placebo-controlled, global phase 3 trial.

Imafuku S, Tada Y, Hippeli L, Banerjee S, Morita A, Ohtsuki M.

J Dermatol. 2023 May;50(5):588-595. doi: 10.1111/1346-8138.16740. Epub 2023 Mar 7.

PMID: 36882942 

 

Disease-free Survival Analysis for Patients with High-risk Muscle-invasive Urothelial Carcinoma from the Randomized CheckMate 274 Trial by PD-L1 Combined Positive Score and Tumor Cell Score.

Galsky MD, Bajorin DF, Witjes JA, Gschwend JE, Tomita Y, Nasroulah F, Li J, Collette S, Valderrama BP, Grimm MO, Appleman L, Gravis G, Necchi A, Ye D, Stenner F, Wind-Rotolo M, Zhang J, Ünsal-Kaçmaz K.

Eur Urol. 2023 May;83(5):432-440. doi: 10.1016/j.eururo.2023.01.016. Epub 2023 Mar 2.

PMID: 36868932 

 

SAIL study of stroke, systemic embolism and bleeding outcomes with warfarin anticoagulation in non-valvular atrial fibrillation (S⁴-BOW-AF).

Harris DE, Torabi F, Mallory D, Akbari A, Thayer D, Wang T, Grundy S, Gravenor M, Alikhan R, Lister S, Halcox J.

Eur Heart J Open. 2023 Apr 13;3(3):oead037. doi: 10.1093/ehjopen/oead037. eCollection 2023 May.

PMID: 37143610 

 

Integrated model of the vertebrate augmin complex.

Travis SM, Mahon BP, Huang W, Ma M, Rale MJ, Kraus J, Taylor DJ, Zhang R, Petry S.

Nat Commun. 2023 Apr 13;14(1):2072. doi: 10.1038/s41467-023-37519-4.

PMID: 37055408 

 

An Update on Anti-thrombotic Therapy Following Transcatheter Aortic Valve Implantation: Expert Cardiologist Opinion from a UK and Ireland Delphi Group.

Zaman A, Prendergast B, Hildick-Smith D, Blackman D, Anderson R, Spence MS, Mylotte D, Smith D, Wilding B, Chapman C, Atkins K, Pollock KG, Qureshi AC, Banning A.

Interv Cardiol. 2023 Apr 10;18:e13. doi: 10.15420/icr.2022.11. eCollection 2023.

PMID: 37398870  

 

Real-world outcomes in metastatic HR+/HER2-, HER2+ and triple negative breast cancer after start of first-line therapy.

W DeClue R, Fisher MD, Gooden K, Walker MS, Le TK.

Future Oncol. 2023 Apr;19(13):909-923. doi: 10.2217/fon-2022-0894. Epub 2023 May 16.

PMID: 37191097 

 

Defining ruxolitinib failure and transition to next-line therapy for patients with myelofibrosis: a modified Delphi panel consensus study.

Mascarenhas J, Nguyen H, Saunders A, Oliver L, Tomkinson H, Perry R, McBride A.

Future Oncol. 2023 Apr;19(11):763-773. doi: 10.2217/fon-2022-1298. Epub 2023 May 10.

PMID: 37161798 

 

Use of a real-world synthetic control arm for direct comparison of lisocabtagene maraleucel and conventional therapy in relapsed/refractory large B-cell lymphoma.

Van Le H, Van Naarden Braun K, Nowakowski GS, Sermer D, Radford J, Townsend W, Ghesquieres H, Menne T, Porpaczy E, Fox CP, Schusterbauer C, Liu FF, Yue L, De Benedetti M, Hasskarl J.

Leuk Lymphoma. 2023 Mar;64(3):573-585. doi: 10.1080/10428194.2022.2160200. Epub 2023 Feb 8.

PMID: 36755418 

 

Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats.

Witchey SK, Sutherland V, Collins B, Roberts G, Shockley KR, Vallant M, Krause J, Cunny H, Waidyanatha S, Mylchreest E, Sparrow B, Moyer R, Behl M.

Toxicol Sci. 2023 Feb 17;191(2):374-386. doi: 10.1093/toxsci/kfac135.

PMID: 36562586 

 

A systematic review of commercial high concentration antibody drug products approved in the US: formulation composition, dosage form design and primary packaging considerations.

Ghosh I, Gutka H, Krause ME, Clemens R, Kashi RS.

MAbs. 2023 Jan-Dec;15(1):2205540. doi: 10.1080/19420862.2023.2205540.

PMID: 37243580 

 

Ranking mAb-excipient interactions in biologics formulations by NMR spectroscopy and computational approaches.

Zhang C, Gossert ST, Williams J, Little M, Barros M, Dear B, Falk B, Kanthe AD, Garmise R, Mueller L, Ilott A, Abraham A.

MAbs. 2023 Jan-Dec;15(1):2212416. doi: 10.1080/19420862.2023.2212416.

PMID: 37218059 

 

Frequency and clinicoeconomic impact of delays to definitive diagnosis of obstructive hypertrophic cardiomyopathy in the United States.

Naidu SS, Sutton MB, Gao W, Fine JT, Xie J, Desai NR, Owens AT.

J Med Econ. 2023 Jan-Dec;26(1):682-690. doi: 10.1080/13696998.2023.2208966.

PMID: 37170479 

Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.

Hu Z, Sitkoff D, Glunz PW, Zou Y, Wang C, Muckelbauer JK, Adam LP, Wexler RR, Quan ML.
Bioorg Med Chem Lett. 2023 Apr 28;88:129304. doi: 10.1016/j.bmcl.2023.129304. Online ahead of print.

PMID: 37119973

 

Applications of single-cell RNA sequencing in drug discovery and development.

Van de Sande B, Lee JS, Mutasa-Gottgens E, Naughton B, Bacon W, Manning J, Wang Y, Pollard J, Mendez M, Hill J, Kumar N, Cao X, Chen X, Khaladkar M, Wen J, Leach A, Ferran E.

Nat Rev Drug Discov. 2023 Apr 28:1-25. doi: 10.1038/s41573-023-00688-4. Online ahead of print.

PMID: 37117846 

 

An adaptive modeling approach using spiking-augmentation method to improve chemometric model performance in bioprocess monitoring.

Zhao Y, Tang Y, Wasalathanthri D, Xu J, Ding J.

Biotechnol Prog. 2023 Apr 27:e3349. doi: 10.1002/btpr.3349. Online ahead of print.

PMID: 37102507
 

Evaluation of Cellular Immune Response to Adeno-Associated Virus-Based Gene Therapy.

Gorovits B, Azadeh M, Buchlis G, Fiscella M, Harrison T, Havert M, Janetzki S, Jawa V, Long B, Mahnke YD, McDermott A, Milton M, Nelson R, Vettermann C, Wu B.

AAPS J. 2023 Apr 26;25(3):47. doi: 10.1208/s12248-023-00814-5.

PMID: 37101079 
 

Development of tandem-column liquid chromatographic methods for pharmaceutical compounds using simulations based on hydrophobic subtraction model parameters.

Liu Z, Zhou Y, Wang Q, Foley JP, Stoll DR, Shackman JG.

J Chromatogr A. 2023 Apr 26;1695:463925. doi: 10.1016/j.chroma.2023.463925. Epub 2023 Mar 12.

PMID: 36965284
 

Evaluation of oncology infusion pharmacy practices: A nationwide survey.

Boyd AM, Sue C, Khandoobhai A, Vinson B, Shaikh H, Sorenson S, Patel V, Snyder B, Bondarenk C, Koukounas Y, Earl M, Jenkins M.

J Oncol Pharm Pract. 2023 Apr 25:10781552231170358. doi: 10.1177/10781552231170358. Online ahead of print.

PMID: 37122190

 

Meeting Report on the 2^nd Chinese American Society for Mass Spectrometry (CASMS) Conference Advancing Biological and Pharmaceutical Mass Spectrometry.

Chen Y, Ge Y, Han X, Hao L, Huan T, Li L, Li L, Li W, Liang X, Lin Y, Liu X, Liu Y, Ma S, Peng J, Shou W, Sun L, Tao WA, Tian Y, Wang YK, Wang Y, Wu R, Wu S, Xia J, Yang Z, Zhang H, Zhang H, Zhao S, Weng N, Huang L.

Mol Cell Proteomics. 2023 Apr 25:100559. doi: 10.1016/j.mcpro.2023.100559. Online ahead of print.

PMID: 37105363 

 

Caregivers of patients with malignant pleural mesothelioma: who provides care, what care do they provide and what burden do they experience?

Moore A, Bennett B, Taylor-Stokes G, Daumont MJ.

Qual Life Res. 2023 Apr 25. doi: 10.1007/s11136-023-03410-4. Online ahead of print.

PMID: 37097405

 

Health-related quality of life in patients with β-thalassemia: Data from the phase 3 BELIEVE trial of luspatercept.

Cappellini MD, Taher AT, Piga A, Shah F, Voskaridou E, Viprakasit V, Porter JB, Hermine O, Neufeld EJ, Thompson AA, Tang D, Yucel A, Lord-Bessen J, Yu P, Guo S, Shetty JK, Miteva D, Zinger T, Backstrom JT, Oliva EN.

Eur J Haematol. 2023 Apr 24. doi: 10.1111/ejh.13975. Online ahead of print.

PMID: 37095595

 

On Ternary Complex Stability in Protein Degradation: In Silico Molecular Glue Binding Affinity Calculations.

Weiss DR, Bortolato A, Sun Y, Cai X, Lai C, Guo S, Shi L, Shanmugasundaram V.

J Chem Inf Model. 2023 Apr 24;63(8):2382-2392. doi: 10.1021/acs.jcim.2c01386. Epub 2023 Apr 10.

PMID: 37037192

 

The trajectory of clinical responses in patients with early rheumatoid arthritis who achieve sustained remission in response to abatacept: subanalysis of AVERT-2, a randomized phase IIIb study.

Emery P, Tanaka Y, Bykerk VP, Bingham CO, Huizinga TWJ, Citera G, Huang KG, Wu C, Connolly SE, Elbez Y, Wong R, Lozenski K, Fleischmann R.

Arthritis Res Ther. 2023 Apr 22;25(1):67. doi: 10.1186/s13075-023-03038-2.

PMID: 37087459 

 

Pegbelfermin in patients with nonalcoholic steatohepatitis and compensated cirrhosis (FALCON 2): a randomized phase 2b study.

Abdelmalek MF, Sanyal AJ, Nakajima A, Neuschwander-Tetri BA, Goodman ZD, Lawitz EJ, Harrison SA, Jacobson IM, Imajo K, Gunn N, Halegoua-DeMarzio D, Akahane T, Boone B, Yamaguchi M, Chatterjee A, Tirucherai GS, Shevell DE, Du S, Charles ED, Loomba R.

Clin Gastroenterol Hepatol. 2023 Apr 21:S1542-3565(23)00311-7. doi: 10.1016/j.cgh.2023.04.012. Online ahead of print.

PMID: 37088458

 

Pegbelfermin in patients with nonalcoholic steatohepatitis and stage 3 fibrosis (FALCON 1): a randomized phase 2b study.

Loomba R, Sanyal AJ, Nakajima A, Neuschwander-Tetri BA, Goodman ZD, Harrison SA, Lawitz EJ, Gunn N, Imajo K, Ravendhran N, Akahane T, Boone B, Yamaguchi M, Chatterjee A, Tirucherai GS, Shevell DE, Du S, Charles ED, Abdelmalek MF.

Clin Gastroenterol Hepatol. 2023 Apr 21:S1542-3565(23)00310-5. doi: 10.1016/j.cgh.2023.04.011. Online ahead of print.

PMID: 37088457

 

Harmonizing Biopredictive Methodologies Through the Product Quality Research Institute (PQRI) Part I: Biopredictive Dissolution of Ibuprofen and Dipyridamole Tablets.

Tsume Y, Ashworth L, Bermejo M, Cheng J, Cicale V, Dressman J, Fushimi M, Gonzalez-Alvarez I, Guo Y, Jankovsky C, Lu X, Matsui K, Patel S, Sanderson N, Sun CC, Thakral NK, Yamane M, Zöller L.

AAPS J. 2023 Apr 21;25(3):45. doi: 10.1208/s12248-023-00793-7.

PMID: 37085637

 

Transplant Referral Patterns for Patients with Newly Diagnosed Higher-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia at Academic and Community Sites in the Connect® Myeloid Disease Registry: Potential Barriers to Care.

Tomlinson B, de Lima M, Cogle CR, Thompson MA, Grinblatt DL, Pollyea DA, Komrokji RS, Roboz GJ, Savona MR, Sekeres MA, Abedi M, Garcia-Manero G, Kurtin SE, Maciejewski JP, Patel JL, Revicki DA, George TI, Flick ED, Kiselev P, Louis CU, DeGutis IS, Nifenecker M, Erba HP, Steensma DP, Scott BL.

Transplant Cell Ther. 2023 Apr 20:S2666-6367(23)01243-5. doi: 10.1016/j.jtct.2023.04.011. Online ahead of print.

PMID: 37086851

 

The AAPS Journal Theme Issue: Compendium of Immunogenicity Risk Assessments: an Industry Guidance Built on Experience and Published Work.

Mora JR, Richards SM.

AAPS J. 2023 Apr 20;25(3):43. doi: 10.1208/s12248-023-00796-4.

PMID: 37081214

 

Comparison of Protein Particle Formation in IgG1 mAbs Formulated with PS20 Vs. PS80 When Subjected to Interfacial Dilatational Stress.

Vaclaw C, Merritt K, Griffin VP, Whitaker N, Gokhale M, Volkin DB, Ogunyankin MO, Dhar P.

AAPS PharmSciTech. 2023 Apr 20;24(5):104. doi: 10.1208/s12249-023-02561-4.

PMID: 37081185 

 

Exposure-Response Analysis to Assess the Concentration-QTc Relationship of Iberdomide.

Cheng Y, Gaudy A, Liu L, Ye Y, Thomas M, Xue Y, Zhou S, Li Y.

Clin Pharmacol Drug Dev. 2023 Apr 20. doi: 10.1002/cpdd.1254. Online ahead of print.

PMID: 37079714

 

An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots.

Wiesner R, Zagst H, Lan W, Bigelow S, Holper P, Hübner G, Josefsson L, Lancaster C, Lo L, Lößner C, Lu H, Neusüß C, Rüttiger C, Schlecht J, Schürrle P, Selsam A, van der Burg D, Wang SC, Zhu Y, Wätzig H, Sänger-van de Griend C.

Electrophoresis. 2023 Apr 20. doi: 10.1002/elps.202200284. Online ahead of print.

PMID: 37079448

 

Health-state utilities in long-term advanced melanoma survivors comparable with the general population.

Egeler MD, van de Poll-Franse LV, Tissier R, Rogiers A, Boers-Sonderen MJ, van den Eertwegh AJ, Hospers GA, de Groot JWB, Aarts MJB, Kapiteijn E, Piersma D, Vreugdenhil G, van der Veldt AA, Suijkerbuijk KPM, Neyns B, Janssen KJ, Blank CU, Retèl VP, Boekhout AH.

Qual Life Res. 2023 Apr 20. doi: 10.1007/s11136-023-03427-9. Online ahead of print.

PMID: 37079262

 

Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.

Cherry C, Andorko JI, Krishnan K, Mejías JC, Nguyen HH, Stivers KB, Gray-Gaillard EF, Ruta A, Han J, Hamada N, Hamada M, Sturmlechner I, Trewartha S, Michel JH, Davenport Huyer L, Wolf MT, Tam AJ, Peña AN, Keerthivasan S, Le Saux CJ, Fertig EJ, Baker DJ, Housseau F, van Deursen JM, Pardoll DM, Elisseeff JH.

Geroscience. 2023 Apr 20. doi: 10.1007/s11357-023-00785-7. Online ahead of print.

PMID: 37079217

 

Heart Failure Across the Range of Mildly Reduced and Preserved Ejection Fraction in the United States.

Greene SJ, Spertus JA, Tang W, Kang A, Zhong Y, Myers MC, Shen S, Jiang J, Liu X, Steffen DR, Viola MG, Felker GM.

Circ Heart Fail. 2023 Apr 20:e010430. doi: 10.1161/CIRCHEARTFAILURE.123.010430. Online ahead of print.

PMID: 37078276 

 

Artificial intelligence in inflammatory bowel disease: implications for clinical practice and future directions.

Ahmad HA, East JE, Panaccione R, Travis S, Canavan JB, Usiskin K, Byrne MF.

Intest Res. 2023 Apr 20. doi: 10.5217/ir.2023.00020. Online ahead of print.

PMID: 37075809

 

Adjuvant Nivolumab Versus Ipilimumab in Resected Stage III/IV Melanoma: 5-Year Efficacy and Biomarker Results From CheckMate 238.

Larkin J, Del Vecchio M, Mandala M, Gogas H, Arance AM, Dalle S, Cowey CL, Schenker M, Grob JJ, Chiarion-Sileni V, Marquez-Rodas I, Butler MO, Di Giacomo AM, Middleton MR, Lutzky J, de la Cruz-Merino L, Arenberger P, Atkinson V, Hill AG, Fecher LA, Millward M, Nathan PD, Khushalani NI, Queirolo P, Ritchings C, Lobo M, Askelson M, Tang H, Dolfi S, Ascierto PA, Weber J.

Clin Cancer Res. 2023 Apr 14:CCR-22-3145. doi: 10.1158/1078-0432.CCR-22-3145. Online ahead of print.

PMID: 37058595

 

Integrated model of the vertebrate augmin complex.

Travis SM, Mahon BP, Huang W, Ma M, Rale MJ, Kraus J, Taylor DJ, Zhang R, Petry S.

Nat Commun. 2023 Apr 13;14(1):2072. doi: 10.1038/s41467-023-37519-4.

PMID: 37055408 

 Effectiveness and safety of anticoagulants among venous thromboembolism cancer patients with and without brain cancer.

Cohen A, Noxon V, Dhamane A, Bruette R, Shah S, Hines DM, Alfred T, Luo X.

Thromb Res. 2023 Apr 13;226:117-126. doi: 10.1016/j.thromres.2023.04.009. Online ahead of print.

PMID: 37146438

 

Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin as a Breast Cancer Resistance Protein -Specific Endogenous Biomarker that Demonstrates Prediction of Transporter Activity In Vivo.

Zhang Y, Shipkova PA, Warrack BM, Nelson DM, Wang L, Huo R, Chen J, Panfen E, Chen XQ, Fancher M, Ruan Q, Christopher LJ, Xue Y, Sinz M, Shen H.

Drug Metab Dispos. 2023 Apr 13:DMD-AR-2023-001284. doi: 10.1124/dmd.123.001284. Online ahead of print.

PMID: 37055191

 

Enantioselective Total Synthesis of (+)-KB343.

Bi C, Wang Y, He C, Baran PS.

J Am Chem Soc. 2023 Apr 12;145(14):7753-7757. doi: 10.1021/jacs.3c01991. Epub 2023 Mar 30.

PMID: 36995337

 

Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.

Markwalder JA, Balog AJ, Williams DK, Nara SJ, Reddy R, Roy S, Kanyaboina Y, Li X, Johnston K, Fan Y, Lewis H, Marsilio F, Yan C, Critton D, Newitt JA, Traeger SC, Wu DR, Jure-Kunkel MN, Jayaraman L, Lin TA, Sinz MW, Hunt JT, Seitz SP.

Bioorg Med Chem Lett. 2023 Apr 11;88:129280. doi: 10.1016/j.bmcl.2023.129280. Online ahead of print.

PMID: 37054759

 

Decentralized clinical trials and rare diseases: a Drug Information Association Innovative Design Scientific Working Group (DIA-IDSWG) perspective.

Ghadessi M, Di J, Wang C, Toyoizumi K, Shao N, Mei C, Demanuele C, Tang RS, McMillan G, Beckman RA.

Orphanet J Rare Dis. 2023 Apr 11;18(1):79. doi: 10.1186/s13023-023-02693-7.

PMID: 37041605 

 

Guest editors' note on special issue on application of estimand.

Seifu Y, Wang W.

J Biopharm Stat. 2023 Apr 11:1-2. doi: 10.1080/10543406.2023.2199835. Online ahead of print.

PMID: 37039452

 

Prior anti-CTLA-4 therapy impacts molecular characteristics associated with anti-PD-1 response in advanced melanoma.

Campbell KM, Amouzgar M, Pfeiffer SM, Howes TR, Medina E, Travers M, Steiner G, Weber JS, Wolchok JD, Larkin J, Hodi FS, Boffo S, Salvador L, Tenney D, Tang T, Thompson MA, Spencer CN, Wells DK, Ribas A.

Cancer Cell. 2023 Apr 10;41(4):791-806.e4. doi: 10.1016/j.ccell.2023.03.010.

PMID: 37037616 

 

Therapy effect on AI-derived thalamic atrophy using clinical routine MRI protocol: A longitudinal, multi-center, propensity-matched multiple sclerosis study.

Jakimovski D, Silva D, Niels Bergsland, Dwyer MG, Weinstock-Guttman B, Benedict RH, Riolo J, Zivadinov R; DeepGRAI Registry Study group.

Mult Scler Relat Disord. 2023 Apr 9;74:104708. doi: 10.1016/j.msard.2023.104708. Online ahead of print.

PMID: 37084495

 

The association between brain volume loss and disability in multiple sclerosis: A systematic review.

Matthews PM, Gupta D, Mittal D, Bai W, Scalfari A, Pollock KG, Sharma V, Hill N.

Mult Scler Relat Disord. 2023 Apr 9;74:104714. doi: 10.1016/j.msard.2023.104714. Online ahead of print.

PMID: 37068369 

 

Strategies for controlling afucosylation in monoclonal antibodies during upstream manufacturing.

Rish AJ, Siddiquee K, Huang Z, Xu J, Anderson CA, Borys MC, Khetan A.

Biotechnol J. 2023 Apr 7:e2200604. doi: 10.1002/biot.202200604. Online ahead of print.

PMID: 37029472 

 

Cross-platform dataset of multiplex fluorescent cellular object image annotations.

Aleynick N, Li Y, Xie Y, Zhang M, Posner A, Roshal L, Pe'er D, Vanguri RS, Hollmann TJ.

Sci Data. 2023 Apr 7;10(1):193. doi: 10.1038/s41597-023-02108-z.

PMID: 37029126 

 

Regorafenib plus nivolumab in patients with mismatch repair-proficient/microsatellite stable metastatic colorectal cancer: a single-arm, open-label, multicentre phase 2 study.

Fakih M, Raghav KPS, Chang DZ, Larson T, Cohn AL, Huyck TK, Cosgrove D, Fiorillo JA, Tam R, D'Adamo D, Sharma N, Brennan BJ, Wang YA, Coppieters S, Zebger-Gong H, Weispfenning A, Seidel H, Ploeger BA, Mueller U, Oliveira CSV, Paulson AS.

EClinicalMedicine. 2023 Apr 6;58:101917. doi: 10.1016/j.eclinm.2023.101917. eCollection 2023 Apr.

PMID: 37090438 

 

Gamma secretase inhibition: Effects on fertility and embryo-fetal development in rats.

Sivaraman L, Sanderson T.

Toxicol Appl Pharmacol. 2023 Apr 6;469:116512. doi: 10.1016/j.taap.2023.116512. Online ahead of print.

PMID: 37030625 

 

Efficacy and Safety of Nivolumab Plus Ipilimumab vs Nivolumab Alone for Treatment of Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: The Phase 2 CheckMate 714 Randomized Clinical Trial.

Harrington KJ, Ferris RL, Gillison M, Tahara M, Argiris A, Fayette J, Schenker M, Bratland Å, Walker JWT, Grell P, Even C, Chung CH, Redman R, Coutte A, Salas S, Grant C, de Azevedo S, Soulières D, Hansen AR, Wei L, Khan TA, Miller-Moslin K, Roberts M, Haddad R.

JAMA Oncol. 2023 Apr 6:e230147. doi: 10.1001/jamaoncol.2023.0147. Online ahead of print.

PMID: 37022706

 

3D Printed Flavor-Rich Chewable Pediatric Tablets Fabricated Using Microextrusion for Point of Care Applications.

Tabriz AG, Hui HW, Boersen N, Roberts S, Jones J, Douroumis D.

Mol Pharm. 2023 Apr 6. doi: 10.1021/acs.molpharmaceut.2c01061. Online ahead of print.

PMID: 37022302

 

High-dose melphalan treatment significantly increases mutational burden at relapse in multiple myeloma.

Samur MK, Roncador M, Aktas Samur A, Fulciniti M, Bazarbachi AH, Szalat R, Shammas MA, Sperling AS, Richardson PG, Magrangeas F, Minvielle S, Perrot A, Corre J, Moreau P, Thakurta A, Parmigiani G, Anderson KC, Avet-Loiseau H, Munshi NC.

Blood. 2023 Apr 6;141(14):1724-1736. doi: 10.1182/blood.2022017094.

PMID: 36603186

 

Analytical characterization of host-cell-protein-rich aggregates in monoclonal antibody solutions.

Herman CE, Min L, Choe LH, Maurer RW, Xu X, Ghose S, Lee KH, Lenhoff AM.

Biotechnol Prog. 2023 Apr 5:e3343. doi: 10.1002/btpr.3343. Online ahead of print.

PMID: 37020359

 

Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication.

Liu Y, Klein J, Bajpai R, Dong L, Tran Q, Kolekar P, Smith JL, Ries RE, Huang BJ, Wang YC, Alonzo TA, Tian L, Mulder HL, Shaw TI, Ma J, Walsh MP, Song G, Westover T, Autry RJ, Gout AM, Wheeler DA, Wan S, Wu G, Yang JJ, Evans WE, Loh M, Easton J, Zhang J, Klco JM, Meshinchi S, Brown PA, Pruett-Miller SM, Ma X.

Nat Commun. 2023 Apr 5;14(1):1739. doi: 10.1038/s41467-023-37438-4.

PMID: 37019972 

 

Greetings from the ASMS Publications Committee.

Valentine S, Phelan V, Zhou M, Thomas S, Cannon J.

J Am Soc Mass Spectrom. 2023 Apr 5;34(4):519-520. doi: 10.1021/jasms.3c00094.

PMID: 37016835 

 

Determining sequential micellization steps of bile salts with multi-CMC modeling.

Rovnyak D, He J, Kong S, Eckenroad KW, Manley GA, Geffert RM, Krout MR, Strein TG.

J Colloid Interface Sci. 2023 Apr 5;644:496-508. doi: 10.1016/j.jcis.2023.03.146. Online ahead of print.

PMID: 37146486

 

Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.

Jurica EA, Wu X, Williams KN, Haque LE, Rampulla RA, Mathur A, Zhou M, Cao G, Cai H, Wang T, Liu H, Xu C, Kunselman LK, Antrilli TM, Hicks MB, Sun Q, Dierks EA, Apedo A, Moore DB, Foster KA, Cvijic ME, Panemangalore R, Khandelwal P, Wilkes JJ, Zinker BA, Robertson DG, Janovitz EB, Galella M, Li YX, Li J, Ramar T, Jalagam PR, Jayaram R, Whaley JM, Barrish JC, Robl JA, Ewing WR, Ellsworth BA.

Bioorg Med Chem. 2023 Apr 4;85:117273. doi: 10.1016/j.bmc.2023.117273. Online ahead of print.

PMID: 37030194

 

Analysis of patient-reported experiences up to 2 years after receiving idecabtagene vicleucel (ide-cel, bb2121) for relapsed or refractory multiple myeloma: Longitudinal findings from the phase 2 KarMMa trial.

Delforge M, Otero PR, Shah N, Moshkovich O, Braverman J, Dhanda DS, Lanar S, Devlen J, Miera M, Gerould H, Campbell TB, Munshi NC.

Leuk Res. 2023 Apr 3;129:107074. doi: 10.1016/j.leukres.2023.107074. Online ahead of print.

PMID: 37087950 

 

Surface ID: a geometry-aware system for protein molecular surface comparison.

Riahi S, Lee JH, Sorenson T, Wei S, Jager S, Olfati-Saber R, Park A, Wendt M, Minoux H, Qiu Y.

Bioinformatics. 2023 Apr 3;39(4):btad196. doi: 10.1093/bioinformatics/btad196.

PMID: 37067488 

 

Corrigendum to real-world treatment patterns and clinical outcomes among patients with advanced urothelial carcinoma in the United States [Urologic oncology: Seminars and original investigations 40 (2022) 195.e1-195.e11].

Geynisman DM, Broughton E, Hao Y, Zhang Y, Le T, Huo S.

Urol Oncol. 2023 Apr 3:S1078-1439(23)00086-8. doi: 10.1016/j.urolonc.2023.03.001. Online ahead of print.

PMID: 37019763 

 

Comparison of Pre-existing Anti-AAV8 Total Antibody Screening and Confirmatory Assays with a Cell-Based Neutralizing Assay in Normal Human Serum.

Dai Y, Dong H, Gleason C, Mora J, Kolaitis G, Balasubramanian N, Surapaneni S, Kozhich A, Jawa V.

AAPS J. 2023 Apr 3;25(3):35. doi: 10.1208/s12248-023-00805-6.

PMID: 37012501

 

Effect of light source and UVA quotient on monoclonal antibody stability during ambient light exposure studies.

More HT, Bindra DS, Zumba A, Zhou K, Carvalho T, Mantri R.

Eur J Pharm Biopharm. 2023 Apr;185:177-182. doi: 10.1016/j.ejpb.2023.03.001. Epub 2023 Mar 7.

PMID: 36894037

 

First-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone (four cycles) in metastatic non-small cell lung cancer: CheckMate 9LA 2-year patient-reported outcomes.

Reck M, Ciuleanu TE, Cobo M, Schenker M, Zurawski B, Menezes J, Richardet E, Bennouna J, Felip E, Juan-Vidal O, Alexandru A, Cheng Y, Sakai H, Paz-Ares L, Lu S, John T, Sun X, Moisei A, Taylor F, Lawrance R, Zhang X, Sylvester J, Yuan Y, Blum SI, Penrod JR, Carbone DP.

Eur J Cancer. 2023 Apr;183:174-187. doi: 10.1016/j.ejca.2023.01.015. Epub 2023 Jan 28.

PMID: 36871487

 

Pharmacodynamic activity of BMS-986156, a glucocorticoid-induced TNF receptor-related protein agonist, alone or in combination with nivolumab in patients with advanced solid tumors.

Wang R, Baxi V, Li Z, Locke D, Hedvat C, Sun Y, Walsh AM, Shao X, Basavanhally T, Greenawalt DM, Patah P, Novosiadly R.

ESMO Open. 2023 Apr;8(2):100784. doi: 10.1016/j.esmoop.2023.100784. Epub 2023 Feb 28.

PMID: 36863094 

 

Evaluation of safety, pharmacokinetics, and pharmacodynamics of apixaban in pediatric subjects at risk of venous or arterial thrombotic disorder.

Merali SJ, Byon W, Patel YT, Elsrougy A, Marchisin D, Perera V, Chen W, He B, Murthy B.

CPT Pharmacometrics Syst Pharmacol. 2023 Apr;12(4):500-512. doi: 10.1002/psp4.12935. Epub 2023 Mar 5.

PMID: 36861188 

 

Trends and factors associated with outpatient anticoagulant treatment initiation among VTE patients with active cancer.

Dhamane AD, Shah S, Noxon V, Bruette R, Ferri M, Liu X, Jiang J, Luo X.

Thromb Res. 2023 Apr;224:52-59. doi: 10.1016/j.thromres.2023.02.001. Epub 2023 Feb 15.

PMID: 36848784

 

Incidence of second primary malignancies in relapsed/refractory B-cell non-Hodgkin's lymphoma patients in England.

Miret M, Anderson A, Hindocha P, Cirneanu L, Lymperopoulou C, Markov E, Kizito W, Vegni FE.

Leuk Res. 2023 Apr;127:107042. doi: 10.1016/j.leukres.2023.107042. Epub 2023 Feb 14.

PMID: 36812661

 

Effectiveness and Safety of Apixaban vs Warfarin in Patients with Venous Thromboembolism with Risk Factors for Bleeding or for Recurrences.

Cohen AT, Sah J, Dhamane AD, Hines DM, Lee T, Rosenblatt L, Emir B, Keshishian A, Yuce H, Luo X.

Adv Ther. 2023 Apr;40(4):1705-1735. doi: 10.1007/s12325-023-02440-1. Epub 2023 Feb 22.

PMID: 36811795 

 

Perspectives on Treatment Burden for Methotrexate and Tumor Necrosis Factor Inhibitors Among Patients With Psoriatic Arthritis and Rheumatoid Arthritis: A Qualitative Study.

Ogdie A, Shaw Y, Almonte M, Maksabedian Hernandez EJ, Stolshek B, Michaud K.

ACR Open Rheumatol. 2023 Apr;5(4):167-172. doi: 10.1002/acr2.11530. Epub 2023 Feb 10.

PMID: 36762609 

 

Venetoclax plus azacitidine compared with intensive chemotherapy as induction for patients with acute myeloid leukemia: retrospective analysis of an electronic medical record database in the United States.

Zeidan AM, Pollyea DA, Borate U, Vasconcelos A, Potluri R, Rotter D, Kiendrebeogo Z, Gaugler L, Prebet T, Strocchia M, Bonifacio G, Chen C.

Ann Hematol. 2023 Apr;102(4):749-754. doi: 10.1007/s00277-023-05109-5. Epub 2023 Feb 3.

PMID: 36732419

 

Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features.

Rodriguez L, Tomer Y, Carson P, Dimopoulos T, Zhao M, Chavez K, Iyer S, Huang L, Ebert C, Sereda L, Murthy A, Trujillo G, Beers MF, Katzen J.

Am J Respir Cell Mol Biol. 2023 Apr;68(4):358-365. doi: 10.1165/rcmb.2022-0203MA.

PMID: 36473455

 

Cost Per Relapse Avoided for Ozanimod Versus Other Selected Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis in the United States.

Kantor D, Pham T, Patterson-Lomba O, Swallow E, Dua A, Gupte-Singh K.

Neurol Ther. 2023 Mar 31. doi: 10.1007/s40120-023-00463-y. Online ahead of print.

PMID: 37000386

 

A Systematic Review of the Economic and Health-Related Quality of Life Impact of Advanced Therapies Used to Treat Moderate-to-Severe Ulcerative Colitis.

Cichewicz A, Tencer T, Gupte-Singh K, Egodage S, Burnett H, Kumar J.

Adv Ther. 2023 Mar 31;40(5):2116-46. doi: 10.1007/s12325-023-02488-z. Online ahead of print.

PMID: 37000363 

 

Evolving regulatory perspectives on digital health technologies for medicinal product development.

Colloud S, Metcalfe T, Askin S, Belachew S, Ammann J, Bos E, Kilchenmann T, Strijbos P, Eggenspieler D, Servais L, Garay C, Konstantakopoulos A, Ritzhaupt A, Vetter T, Vincenzi C, Cerreta F.

NPJ Digit Med. 2023 Mar 29;6(1):56. doi: 10.1038/s41746-023-00790-2.

PMID: 36991116 

 

Oral azacitidine modulates the bone marrow microenvironment in patients with acute myeloid leukaemia in remission: A subanalysis from the QUAZAR AML-001 trial.

Menezes DL, See WL, Risueño A, Tsai KT, Lee JK, Ma J, Khan R, Prebet T, Skikne B, Beach CL, Thakurta A, Gandhi A.

Br J Haematol. 2023 Mar 29. doi: 10.1111/bjh.18783. Online ahead of print.

PMID: 36990798

 

SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol.

Espinasse A, Solovyeva O, Dimairo M, Weir C, Jaki T, Mander A, Kightley A, Evans J, Lee S, Bedding A, Hopewell S, Rantell K, Liu R, Chan AW, De Bono J, Yap C.

BMJ Open. 2023 Mar 29;13(3):e068173. doi: 10.1136/bmjopen-2022-068173.

PMID: 36990492 

 

Morphological distribution mapping: Utilisation of modelling to integrate particle size and shape distributions.

Gamble JF, Akseli I, Ferreira AP, Leane M, Thomas S, Tobyn M, Wadams RC.

Int J Pharm. 2023 Mar 25;635:122743. doi: 10.1016/j.ijpharm.2023.122743. Epub 2023 Feb 17.

PMID: 36804520

 

TACH101, a first-in-class pan-inhibitor of KDM4 histone demethylase.

Chandhasin C, Dang V, Perabo F, Del Rosario J, Chen YK, Filvaroff E, Stafford JA, Clarke M.

Anticancer Drugs. 2023 Mar 24. doi: 10.1097/CAD.0000000000001514. Online ahead of print.

PMID: 37067993

 

Variables associated with joint involvement and development of a prediction rule for arthritis in patients with psoriasis. An analysis of the Italian PsoReal database.

Heidemeyer K, Cazzaniga S, Dondi L, Ronconi G, Pedrini A, Bellatreccia A, Zhong Y, Martini N, Naldi L.

J Am Acad Dermatol. 2023 Mar 23:S0190-9622(23)00500-5. doi: 10.1016/j.jaad.2023.02.059. Online ahead of print.

PMID: 36965671

 

Development and validation of a measure of adolescent and young adult goal-based quality of life (MAYA-GQOL).

Darabos K, Tucker CA, Brumley L, King-Dowling S, Butler E, Stevens E, O'Hagan B, Henry-Moss D, Deatrick JA, Szalda D, Barakat LP, Schwartz LA.

Qual Life Res. 2023 Mar 23. doi: 10.1007/s11136-023-03392-3. Online ahead of print.

PMID: 36952075

 

Survival outcomes with oral azacitidine maintenance in patients with acute myeloid leukemia in remission by receipt of initial chemotherapy: subgroup analyses from the phase 3 QUAZAR AML-001 trial.

Wei AH, Roboz GJ, Dombret H, Dohner H, Schuh AC, Montesinos P, Selleslag D, Bondarenko SN, Prebet T, Lai Y, Skikne B, Beach CL, Ravandi F.

Haematologica. 2023 Mar 23. doi: 10.3324/haematol.2022.282296. Online ahead of print.

PMID: 36951156 

 

Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors.

Hartz RA, Ahuja VT, Sivaprakasam P, Xiao H, Krause CM, Clarke WJ, Kish K, Lewis H, Szapiel N, Ravirala R, Mutalik S, Nakmode D, Shah D, Burton CR, Macor JE, Dubowchik GM.

J Med Chem. 2023 Mar 23;66(6):4231-4252. doi: 10.1021/acs.jmedchem.3c00133. Epub 2023 Mar 9.

PMID: 36950863

 

Psychometric evaluation of the NTDT-PRO questionnaire for assessing symptoms in patients with non-transfusion-dependent beta-thalassaemia.

Taher AT, Musallam KM, Viprakasit V, Kattamis A, Lord-Bessen J, Yucel A, Guo S, Pelligra C, Shields AL, Shetty JK, Miteva D, Bueno LM, Cappellini MD.

BMJ Open. 2023 Mar 22;13(3):e066683. doi: 10.1136/bmjopen-2022-066683.

PMID: 36948565 

  

Cost-Effectiveness of Lisocabtagene Maraleucel Versus Axicabtagene Ciloleucel and Tisagenlecleucel in the Third-Line or Later Treatment Setting for Relapsed or Refractory Large B-cell Lymphoma in the United States.

Parker C, Liu FF, Deger KA, Franco-Villalobos C, Proskorovsky I, Keating SJ, Sorensen S.

Adv Ther. 2023 Mar 22;40(5):2355-74. doi: 10.1007/s12325-023-02444-x. Online ahead of print.

PMID: 36947328 

 

Comparing treatment and outcomes in advanced esophageal, gastroesophageal junction, and gastric adenocarcinomas: a population-based study.

Pape M, Vissers PAJ, Dijksterhuis WPM, Bertwistle D, McDonald L, Mostert B, Derks S, Oving IM, Verhoeven RHA, van Laarhoven HWM.

Ther Adv Med Oncol. 2023 Mar 21;15:17588359231162576. doi: 10.1177/17588359231162576. eCollection 2023.

PMID: 36970109 

 

Characterization of serum and tissue oxytocinase and tissue oxytocin in the pregnant and non-pregnant mare.

Diel de Amorim M, Dong L, Byron M, Foster RA, Klein C, Saleh M, Saleh T, Card C.

Sci Rep. 2023 Mar 21;13(1):4616. doi: 10.1038/s41598-023-31540-9.

PMID: 36944665 

 

Quality-adjusted time without symptoms or toxicity analysis of nivolumab plus chemotherapy versus chemotherapy alone for the management of previously untreated patients with advanced gastric cancer, gastroesophageal junction cancer, or esophageal adenocarcinoma.

Lin D, Nguyen H, Shah R, Qiao Y, Hartman J, Sugarman R.

Gastric Cancer. 2023 Mar 21;26(3):415-24. doi: 10.1007/s10120-023-01372-7. Online ahead of print.

PMID: 36943511 

 

Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins.

Chu LK, Borujeni EE, Xu X, Ghose S, Zydney AL.

Biotechnol Bioeng. 2023 Mar 16. doi: 10.1002/bit.28386. Online ahead of print.

PMID: 36929487

 

Population characteristics, management, and survival outcomes in muscle-invasive urothelial carcinoma undergoing radical resection: the MINOTAUR study.

Roupret M, Brouquet A, Colrat F, Diez-Andreu P, Prudent A, Chartier M, Gaudin AF, Bugnard F, Chillotti L, Bénard S, Branchoux S, Bellera C, Negrier S.

World J Urol. 2023 Mar 16:1-7. doi: 10.1007/s00345-023-04335-w. Online ahead of print.

PMID: 36929410 

 

Modeling unmeasured baseline information in observational time-to-event data subject to delayed study entry.

Stegherr R, Beyersmann J, Bramlage P, Bluhmki T.

Stat Methods Med Res. 2023 Mar 16:9622802231163334. doi: 10.1177/09622802231163334. Online ahead of print.

PMID: 36924264 

 

A strategy for evaluation of isotopic enrichment and structural integrity of deuterium labelled compounds by using HR-MS and NMR.

Kumar S, Gajjela R, Kumar H, Arulraj RA, Subramaniam S, Kothandaramachandran T, Sudhir V S, Chauthe SK, Gupta A, Mathur A, Roy A, Bagadi M, Caceres-Cortes J.

Anal Methods. 2023 Mar 16;15(11):1470-1477. doi: 10.1039/d2ay01980a.

PMID: 36876453

 

Ide-cel or Standard Regimens in Relapsed and Refractory Multiple Myeloma.

Rodriguez-Otero P, Ailawadhi S, Arnulf B, Patel K, Cavo M, Nooka AK, Manier S, Callander N, Costa LJ, Vij R, Bahlis NJ, Moreau P, Solomon SR, Delforge M, Berdeja J, Truppel-Hartmann A, Yang Z, Favre-Kontula L, Wu F, Piasecki J, Cook M, Giralt S.

N Engl J Med. 2023 Mar 16;388(11):1002-1014. doi: 10.1056/NEJMoa2213614. Epub 2023 Feb 10.c

PMID: 36762851 

 

Machine Learning and Assay Development for Image-based Phenotypic Profiling of Drug Treatments.

Sexton JZ, Fursmidt R, O’Meara MJ, Omta W, Rao A, Egan DA, Haney SA.

2023 Mar 15. 

In: Markossian S, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Haas JV, Hall MD, Hoare S, Inglese J, Iversen PW, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Saradjian P, Sittampalam GS, Tarselli M, Trask OJ Jr, Wang Y, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–.

PMID: 36921077 

 

A plain language summary of the CheckMate 649 study: nivolumab in combination with chemotherapy compared to chemotherapy alone for untreated advanced or metastatic cancer of the stomach or esophagus.

Janjigian YY, Shitara K, Moehler M, Garrido M, Salman P, Wyrwicz L, Yamaguchi K, Skoczylas T, Bragagnoli AC, Liu T, Schenker M, Yanez P, Tehfe M, Kowalyszyn R, Karamouzis MV, Bruges R, Zander T, Pazo-Cid R, Hitre E, Feeney K, Cleary JM, Poulart V, Cullen D, Lei M, Xiao H, Kondo K, Li M, Ajani JA.

Future Oncol. 2023 Mar 15. doi: 10.2217/fon-2022-1149. Online ahead of print.

PMID: 36919706 

 

Role of the gradient slope during the product internal recycling for the multicolumn countercurrent solvent gradient purification of PEGylated proteins.

Kim TK, Bham AA, Fioretti I, Angelo J, Xu X, Ghose S, Morbidelli M, Sponchioni M.

J Chromatogr A. 2023 Mar 15;1692:463868. doi: 10.1016/j.chroma.2023.463868. Epub 2023 Feb 10.

PMID: 36803771

 

High Interobserver Variability among Pathologists Using Combined Positive Score to Evaluate PD-L1 Expression in Gastric, Gastroesophageal Junction and Esophageal Adenocarcinoma.

Robert ME, Rüschoff J, Jasani B, Graham RP, Badve SS, Rodriguez-Justo M, Kodach LL, Srivastava A, Wang HL, Tang LH, Troncone G, Rojo F, Van Treeck BJ, Pratt J, Shnitsar I, Kumar G, Karasarides M, Anders RA.

Mod Pathol. 2023 Mar 14:100154. doi: 10.1016/j.modpat.2023.100154. Online ahead of print.

PMID: 36925069

 

Capillary blood collection: exploring a new method to promote noninvasive prenatal screening access.

Ehrich M, Sagaser KG, Porreco RP, Bellesheim D, Patil AS, Shulman LP, Van Den Boom D.

Am J Obstet Gynecol. 2023 Mar 13:S0002-9378(23)00153-9. doi: 10.1016/j.ajog.2023.03.008. Online ahead of print.

PMID: 36921913 

 

BET inhibitor trotabresib in heavily pretreated patients with solid tumors and diffuse large B-cell lymphomas.

Moreno V, Vieito M, Sepulveda JM, Galvao V, Hernández-Guerrero T, Doger B, Saavedra O, Carlo-Stella C, Michot JM, Italiano A, Magagnoli M, Carpio C, Pinto A, Sarmiento R, Amoroso B, Aronchik I, Filvaroff E, Hanna B, Wei X, Nikolova Z, Braña I.

Nat Commun. 2023 Mar 13;14(1):1359. doi: 10.1038/s41467-023-36976-1.

PMID: 36914652 

 

Adjuvant nivolumab plus ipilimumab versus placebo for localised renal cell carcinoma after nephrectomy (CheckMate 914): a double-blind, randomised, phase 3 trial.

Motzer RJ, Russo P, Grünwald V, Tomita Y, Zurawski B, Parikh O, Buti S, Barthélémy P, Goh JC, Ye D, Lingua A, Lattouf JB, Albigès L, George S, Shuch B, Sosman J, Staehler M, Vázquez Estévez S, Simsek B, Spiridigliozzi J, Chudnovsky A, Bex A.

Lancet. 2023 Mar 11;401(10379):821-832. doi: 10.1016/S0140-6736(22)02574-0. Epub 2023 Feb 9.

PMID: 36774933 

 

Nivolumab combined with brentuximab vedotin for relapsed/refractory mediastinal gray zone lymphoma.

Santoro A, Moskowitz AJ, Ferrari S, Carlo-Stella C, Lisano JM, Francis S, Wen R, Akyol A, Savage KJ.

Blood. 2023 Mar 10:blood.2022017951. doi: 10.1182/blood.2022017951. Online ahead of print.

PMID: 36898084 

 

Sex Differences in Oral Anticoagulation Therapy in Patients Hospitalized With Atrial Fibrillation: A Nationwide Cohort Study.

Lee KK, Doudesis D, Bing R, Astengo F, Perez JR, Anand A, McIntyre S, Bloor N, Sandler B, Lister S, Pollock KG, Qureshi AC, McAllister DA, Shah ASV, Mills NL.

J Am Heart Assoc. 2023 Mar 7;12(5):e027211. doi: 10.1161/JAHA.122.027211. Epub 2023 Mar 2.

PMID: 36864741 

 

Safety and immunogenicity of a thermostable ID93 + GLA-SE tuberculosis vaccine candidate in healthy adults.

Sagawa ZK, Goman C, Frevol A, Blazevic A, Tennant J, Fisher B, Day T, Jackson S, Lemiale F, Toussaint L, Kalisz I, Jiang J, Ondrejcek L, Mohamath R, Vergara J, Lew A, Beckmann AM, Casper C, Hoft DF, Fox CB.

Nat Commun. 2023 Mar 6;14(1):1138. doi: 10.1038/s41467-023-36789-2.

PMID: 36878897 

 

Silver Nanoparticles in Dental Applications: A Descriptive Review.

Mallineni SK, Sakhamuri S, Kotha SL, AlAsmari ARGM, AlJefri GH, Almotawah FN, Mallineni S, Sajja R.

Bioengineering (Basel). 2023 Mar 5;10(3):327. doi: 10.3390/bioengineering10030327.

PMID: 36978718 

 

Bayesian optimal phase II designs with dual-criterion decision making.

Zhao Y, Li D, Liu R, Yuan Y.

Pharm Stat. 2023 Mar 5. doi: 10.1002/pst.2296. Online ahead of print.

PMID: 36871961

 

Principled leveraging of external data in the evaluation of diagnostic devices via the propensity score-integrated composite likelihood approach.

Song C, Li H, Chen WC, Lu N, Tiwari R, Wang C, Xu Y, Yue LQ.

Pharm Stat. 2023 Mar 5. doi: 10.1002/pst.2295. Online ahead of print.

PMID: 36871949

 

HLH-like toxicities predict poor survival following use of tisagenlecleucel in children and young adults with B-ALL.

McNerney KO, Si Lim S, Ishikawa K, Dreyzin A, Vatsayan A, Chen JJ, Baggott C, Prabhu S, Pacenta HL, Phillips CL, Rossoff J, Stefanski HE, Talano JA, Moskop A, Verneris MR, Myers D, Karras NA, Brown PA, Bonifant CL, Qayed M, Hermiston ML, Satwani P, Krupski C, Keating AK, Baumeister SHC, Fabrizio VA, Chinnabhandar V, Egeler E, Mavroukakis S, Curran KJ, Mackall CL, Laetsch TW, Schultz LM.

Blood Adv. 2023 Mar 1:bloodadvances.2022008893. doi: 10.1182/bloodadvances.2022008893. Online ahead of print.

PMID: 36857419

 

Contemporary prevalence estimates of undiagnosed and diagnosed atrial fibrillation in the United States.

Turakhia MP, Guo JD, Keshishian A, Delinger R, Sun X, Ferri M, Russ C, Cato M, Yuce H, Hlavacek P.

Clin Cardiol. 2023 Mar 1. doi: 10.1002/clc.23983. Online ahead of print.

PMID: 36855960 

 

Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors.

Kluger H, Barrett JC, Gainor JF, Hamid O, Hurwitz M, LaVallee T, Moss RA, Zappasodi R, Sullivan RJ, Tawbi H, Sharon E.

J Immunother Cancer. 2023 Mar;11(3):e005921. doi: 10.1136/jitc-2022-005921.

PMID: 36918224 

 

Economic Evaluation of Nivolumab Versus Docetaxel for the Treatment of Advanced Squamous and Non-squamous Non-small Cell Lung Cancer After Prior Chemotherapy in China.

Hu S, Tang Z, Harrison JP, Hertel N, Penrod JR, May JR, Juarez-Garcia A, Holdgate O.

Pharmacoecon Open. 2023 Mar;7(2):273-284. doi: 10.1007/s41669-022-00383-x. Epub 2023 Mar 10.

PMID: 36897427 

 

Harnessing imaging tools to guide immunotherapy trials: summary from the National Cancer Institute Cancer Imaging Steering Committee workshop.

Shankar LK, Schöder H, Sharon E, Wolchok J, Knopp MV, Wahl RL, Ellingson BM, Hall NC, Yaffe MJ, Towbin AJ, Farwell MD, Pryma D, Poussaint TY, Wright CL, Schwartz L, Harisinghani M, Mahmood U, Wu AM, Leung D, de Vries EGE, Tang Y, Beach G, Reeves SA.

Lancet Oncol. 2023 Mar;24(3):e133-e143. doi: 10.1016/S1470-2045(22)00742-2.

PMID: 36858729 

 

Estimating long-term progression-free and overall survival in patients with peripheral T-cell lymphoma: A US population-based oncology simulation model based on 5-year results from the ECHELON-2 trial.

Burke JM, Yu KS, Mordi U, Bloudek B, Liu N, Phillips T.

J Manag Care Spec Pharm. 2023 Mar;29(3):314-323. doi: 10.18553/jmcp.2023.29.3.314.

PMID: 36840956

 

Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population.

Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, Loukola A, Lahtela E, Mattsson H, Laiho P, Della Briotta Parolo P, Lehisto AA, Kanai M, Mars N, Rämö J, Kiiskinen T, Heyne HO, Veerapen K, Rüeger S, Lemmelä S, Zhou W, Ruotsalainen S, Pärn K, Hiekkalinna T, Koskelainen S, Paajanen T, Llorens V, Gracia-Tabuenca J, Siirtola H, Reis K, Elnahas AG, Sun B, Foley CN, Aalto-Setälä K, Alasoo K, Arvas M, Auro K, Biswas S, Bizaki-Vallaskangas A, Carpen O, Chen CY, Dada OA, Ding Z, Ehm MG, Eklund K, Färkkilä M, Finucane H, Ganna A, Ghazal A, Graham RR, Green EM, Hakanen A, Hautalahti M, Hedman ÅK, Hiltunen M, Hinttala R, Hovatta I, Hu X, Huertas-Vazquez A, Huilaja L, Hunkapiller J, Jacob H, Jensen JN, Joensuu H, John S, Julkunen V, Jung M, Junttila J, Kaarniranta K, Kähönen M, Kajanne R, Kallio L, Kälviäinen R, Kaprio J; FinnGen; Kerimov N, Kettunen J, Kilpeläinen E, Kilpi T, Klinger K, Kosma VM, Kuopio T, Kurra V, Laisk T, Laukkanen J, Lawless N, Liu A, Longerich S, Mägi R, Mäkelä J, Mäkitie A, Malarstig A, Mannermaa A, Maranville J, Matakidou A, Meretoja T, Mozaffari SV, Niemi MEK, Niemi M, Niiranen T, O Donnell CJ, Obeidat…See abstract for full author list ➔

Nature. 2023 Mar;615(7952):E19. doi: 10.1038/s41586-023-05837-8.

PMID: 36829046 

 

Contrived Materials and a Data Set for the Evaluation of Liquid Biopsy Tests: A Blood Profiling Atlas in Cancer (BLOODPAC) Community Study.

Hernandez KM, Bramlett KS, Agius P, Baden J, Cao R, Clement O, Corner AS, Craft J, Dean DA 2nd, Dry JR, Grigaityte K, Grossman RL, Hicks J, Higa N, Holzer TR, Jensen J, Johann DJ, Katz S, Kolatkar A, Keynton JL, Lee JSH, Maar D, Martini JF, Meyer CG, Roberts PC, Ryder M, Salvatore L, Schageman JJ, Somiari S, Stetson D, Stern M, Xu L, Leiman LC.

J Mol Diagn. 2023 Mar;25(3):143-155. doi: 10.1016/j.jmoldx.2022.12.003.

PMID: 36828596 

 

Plain language summary of the CheckMate 816 study results: nivolumab plus chemotherapy given before surgery for non-small-cell lung cancer.

Forde PM, Spicer J, Lu S, Provencio M, Mitsudomi T, Awad MM, Felip E, Broderick SR, Brahmer JR, Swanson SJ, Kerr K, Wang C, Ciuleanu TE, Saylors GB, Tanaka F, Ito H, Chen KN, Liberman M, Vokes EE, Taube JM, Dorange C, Cai J, Fiore J, Jarkowski A, Balli D, Sausen M, Pandya D, Calvet CY, Girard N.

Future Oncol. 2023 Mar;19(8):549-557. doi: 10.2217/fon-2023-0007. Epub 2023 Feb 23.

PMID: 36815433 

 

Comparative efficacy and safety of ozanimod and ponesimod for relapsing multiple sclerosis: A matching-adjusted indirect comparison.

Swallow E, Pham T, Patterson-Lomba O, Yin L, Gomez-Lievano A, Liu J, Tencer T, Gupte-Singh K.

Mult Scler Relat Disord. 2023 Mar;71:104551. doi: 10.1016/j.msard.2023.104551. Epub 2023 Feb 6.

PMID: 36791623 

 

Use of a real-world synthetic control arm for direct comparison of lisocabtagene maraleucel and conventional therapy in relapsed/refractory large B-cell lymphoma.

Van Le H, Van Naarden Braun K, Nowakowski GS, Sermer D, Radford J, Townsend W, Ghesquieres H, Menne T, Porpaczy E, Fox CP, Schusterbauer C, Liu FF, Yue L, De Benedetti M, Hasskarl J.Leuk Lymphoma. 2023 Mar;64(3):573-585. doi: 10.1080/10428194.2022.2160200. Epub 2023 Feb 8.

PMID: 36755418 

 

Long-term comparative efficacy and safety of nivolumab plus ipilimumab relative to other first-line therapies for advanced non-small-cell lung cancer: A systematic literature review and network meta-analysis.

O'Byrne K, Popoff E, Badin F, Lee A, Yuan Y, Lozano-Ortega G, Eccles LJ, Varol N, Waser N, Penrod JR, Goring S.

Lung Cancer. 2023 Mar;177:11-20. doi: 10.1016/j.lungcan.2023.01.006. Epub 2023 Jan 11.

PMID: 36669321 

Baseline risk factors associated with immune related adverse events and atezolizumab.

Madjar K, Mohindra R, Durán-Pacheco G, Rasul R, Essioux L, Maiya V, Chandler GS.

Front Oncol. 2023 Feb 28;13:1138305. doi: 10.3389/fonc.2023.1138305. eCollection 2023.

PMID: 36925916 

 

A Phase 1, Multicenter, Open-Label Study to Evaluate the Pharmacokinetics of Iberdomide in Subjects with Mild, Moderate, or Severe Hepatic Impairment Compared with Healthy Subjects.

Cheng Y, Ye Y, Gaudy A, Ghosh A, Xue Y, Wang A, Zhou S, Li Y.

Clin Pharmacol. 2023 Feb 28;15:9-19. doi: 10.2147/CPAA.S397826. eCollection 2023.

PMID: 36880014 

 

Residue-Level Characterization of Antibody Binding Epitopes Using Carbene Chemical Footprinting.

Hogan JM, Lee PS, Wong SC, West SM, Morishige WH, Bee C, Tapia GC, Rajpal A, Strop P, Dollinger G.

Anal Chem. 2023 Feb 28;95(8):3922-3931. doi: 10.1021/acs.analchem.2c03091. Epub 2023 Feb 15.

PMID: 36791402

 

Peripheral blood monocytosis is associated with long-term disease severity in pediatric-onset inflammatory bowel disease.

Zhang X, Ramos-Rivers C, Prathapan K, Wang X, Tang G, Kim S, Binion DG.

J Pediatr Gastroenterol Nutr. 2023 Feb 27:e003755. doi: 10.1097/MPG.0000000000003755. Online ahead of print

.PMID: 36827967

 

Rate of castration-induced prostate stroma regression is reduced in a mouse model of benign prostatic hyperplasia.

Zhang R, Singh S, Pan C, Xu B, Kindblom J, Eng KH, Krolewski JJ, Nastiuk KL.

Am J Clin Exp Urol. 2023 Feb 25;11(1):12-26. eCollection 2023.

PMID: 36923722 

 

A Matching-adjusted Indirect Comparison of Nivolumab Plus Cabozantinib Versus Pembrolizumab Plus Axitinib in Patients with Advanced Renal Cell Carcinoma.

McGregor B, Geynisman DM, Burotto M, Suárez C, Bourlon MT, Barata PC, Gulati S, Huo S, Ejzykowicz F, Blum SI, Del Tejo V, Hamilton M, May JR, Du EX, Wu A, Kral P, Ivanescu C, Chin A, Betts KA, Lee CH, Choueiri TK, Cella D, Porta C.

Eur Urol Oncol. 2023 Feb 24:S2588-9311(23)00031-7. doi: 10.1016/j.euo.2023.01.012. Online ahead of print.

PMID: 36842942 

 

Impact of Elotuzumab Plus Pomalidomide/Dexamethasone on Health-related Quality of Life for Patients With Relapsed/Refractory Multiple Myeloma: Final Data From the Phase 2 ELOQUENT-3 Trial.

Weisel K, Dimopoulos MA, San-Miguel J, Paner A, Engelhardt M, Taylor F, Lord-Bessen J, Yip C, Greenwood M, Tang J, Cavo M.

Hemasphere. 2023 Feb 24;7(3):e843. doi: 10.1097/HS9.0000000000000843. eCollection 2023 Mar.

PMID: 36860268 

 

Global retrospective analysis of clinician- and patient-reported clinical characteristics and humanistic burden of patients with gastroesophageal cancers on first-line treatment.

Xiao H, Bertwistle D, Khela K, Middleton-Dalby C, Hall J.

BMC Cancer. 2023 Feb 23;23(1):186. doi: 10.1186/s12885-023-10553-7.

PMID: 36823552 

 

Systematic Literature Review of Real-World Evidence on Dose Escalation and Treatment Switching in Ulcerative Colitis.

Singh H, Wilson L, Tencer T, Kumar J.

Clinicoecon Outcomes Res. 2023 Feb 22;15:125-138. doi: 10.2147/CEOR.S391413. eCollection 2023.

PMID: 36855750 

 

Artificial Intelligence in Inflammatory Bowel Disease Endoscopy: Implications for Clinical Trials.

Ahmad HA, East JE, Panaccione R, Travis S, Canavan JB, Usiskin K, Byrne MF.

J Crohns Colitis. 2023 Feb 22:jjad029. doi: 10.1093/ecco-jcc/jjad029. Online ahead of print.

PMID: 36812142

 

Current State and Opportunities with Long-acting Injectables: Industry Perspectives from the Innovation and Quality Consortium "Long-Acting Injectables" Working Group.

Bauer A, Berben P, Chakravarthi SS, Chattorraj S, Garg A, Gourdon B, Heimbach T, Huang Y, Morrison C, Mundhra D, Palaparthy R, Saha P, Siemons M, Shaik NA, Shi Y, Shum S, Thakral NK, Urva S, Vargo R, Koganti VR, Barrett SE.

Pharm Res. 2023 Feb 22. doi: 10.1007/s11095-022-03391-y. Online ahead of print.

PMID: 36811809 Review.

 

Combinatorial biomarker for predicting outcomes to anti-PD-1 therapy in patients with metastatic clear cell renal cell carcinoma.

Deutsch JS, Lipson EJ, Danilova L, Topalian SL, Jedrych J, Baraban E, Ged Y, Singla N, Choueiri TK, Gupta S, Motzer RJ, McDermott D, Signoretti S, Atkins M, Taube JM.

Cell Rep Med. 2023 Feb 21;4(2):100947. doi: 10.1016/j.xcrm.2023.100947.

PMID: 36812889 

 

Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment.

Szabo PM, Vajdi A, Kumar N, Tolstorukov MY, Chen BJ, Edwards R, Ligon KL, Chasalow SD, Chow KH, Shetty A, Bolisetty M, Holloway JL, Golhar R, Kidd BA, Hull PA, Houser J, Vlach L, Siemers NO, Saha S.

Sci Rep. 2023 Feb 21;13(1):3051. doi: 10.1038/s41598-023-28480-9.

PMID: 36810872 

 

Health outcomes and healthcare resource utilization among Veterans with stage IV non-small cell lung cancer treated with second-line chemotherapy versus immunotherapy.

Williams CD, Allo MA, Gu L, Vashistha V, Press A, Kelley M.

PLoS One. 2023 Feb 21;18(2):e0282020. doi: 10.1371/journal.pone.0282020. eCollection 2023.

PMID: 36809528 

 

Isolation and characterization of pseudo degradation products of acalabrutinib using ESI-HRMS/MS and NMR: Formation of possible geometrical isomers.

Panda S, Das M, Kandula RR, Gajjela R, Ravuri NDH, Kumar H, Kalamse S, Mathur A, Roy A, Bagadi M.

J Pharm Biomed Anal. 2023 Feb 20;225:115214. doi: 10.1016/j.jpba.2022.115214. Epub 2022 Dec 29.

PMID: 36621281

 

A discrete choice experiment on oral and injection treatment preferences among moderate-to-severe psoriasis patients in Japan.

Komine M, Kim H, Yi J, Zhong Y, Sakai Y, Crawford B, Habiro K, Hikichi Y, Feldman SR.

J Dermatol. 2023 Feb 20. doi: 10.1111/1346-8138.16746. Online ahead of print.

PMID: 36808765

 

Nivolumab With or Without Ipilimumab in Pediatric Patients With High-Grade CNS Malignancies: Safety, Efficacy, Biomarker, and Pharmacokinetics: CheckMate 908.

Dunkel IJ, Doz F, Foreman NK, Hargrave D, Lassaletta A, André N, Hansford JR, Hassall T, Eyrich M, Gururangan S, Bartels U, Gajjar A, Howell L, Warad D, Pacius M, Tam R, Wang Y, Zhu L, Cohen K.

Neuro Oncol. 2023 Feb 20:noad031. doi: 10.1093/neuonc/noad031. Online ahead of print.

PMID: 36808285

 

Structurally Diverse Bench-Stable Nickel(0) Pre-Catalysts: A Practical Toolkit for In Situ Ligation Protocols.

Tran VT, Kim N, Rubel CZ, Wu X, Kang T, Jankins TC, Li ZQ, Joannou MV, Ayers S, Gembicky M, Bailey J, Sturgell EJ, Sanchez BB, Chen JS, Lin S, Eastgate MD, Wisniewski SR, Engle KM.

Angew Chem Int Ed Engl. 2023 Feb 20;62(9):e202211794. doi: 10.1002/anie.202211794. Epub 2023 Jan 18.

PMID: 36524997

 

In Support of Early-Career Researchers.

Bandichhor R, Borovik AS, Bettencourt-Dias A, Eastgate MD, Radu NS, Shi F, McElwee-White L.

J Org Chem. 2023 Feb 17;88(4):1923-1927. doi: 10.1021/acs.joc.3c00130. Epub 2023 Feb 2.

PMID: 36727963 

 

Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats.

Witchey SK, Sutherland V, Collins B, Roberts G, Shockley KR, Vallant M, Krause J, Cunny H, Waidyanatha S, Mylchreest E, Sparrow B, Moyer R, Behl M.Toxicol Sci. 2023 Feb 17;191(2):374-386. doi: 10.1093/toxsci/kfac135.PMID: 36562586 

 

Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions.

Fisher KJ, Kinsey R, Mohamath R, Phan T, Liang H, Orr MT, Lykins WR, Guderian JA, Bakken J, Argilla D, Ramer-Denisoff G, Larson E, Qi Y, Sivananthan S, Smolyar K, Carter D, Paddon CJ, Fox CB.

NPJ Vaccines. 2023 Feb 16;8(1):14. doi: 10.1038/s41541-023-00608-y.

PMID: 36797262 

 

In vitro assessment of the binding and functional responses of ozanimod and its plasma metabolites across human sphingosine 1-phosphate receptors.

Selkirk JV, Yan YG, Ching N, Paget K, Hargreaves R.

Eur J Pharmacol. 2023 Feb 15;941:175442. doi: 10.1016/j.ejphar.2022.175442. Epub 2022 Dec 5.

PMID: 36470447 

 

Characterizing the exposure-response relationship of idecabtagene vicleucel in patients with relapsed/refractory multiple myeloma.

Connarn JN, Witjes H, van Zutphen-van Geffen M, de Greef R, Campbell TB, Hege K, Zhou S, Lamba M.

CPT Pharmacometrics Syst Pharmacol. 2023 Feb 15. doi: 10.1002/psp4.12922. Online ahead of print.

PMID: 36794354 

 

Nivolumab and Relatlimab in Patients With Advanced Melanoma That Had Progressed on Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy: Results From the Phase I/IIa RELATIVITY-020 Trial.

Ascierto PA, Lipson EJ, Dummer R, Larkin J, Long GV, Sanborn RE, Chiarion-Sileni V, Dréno B, Dalle S, Schadendorf D, Callahan MK, Nyakas M, Atkinson V, Gomez-Roca CA, Yamazaki N, Tawbi HA, Sarkis N, Warad D, Dolfi S, Mitra P, Suryawanshi S, Grob JJ.

J Clin Oncol. 2023 Feb 13:JCO2202072. doi: 10.1200/JCO.22.02072. Online ahead of print.

PMID: 36780608

 

In Support of Early-Career Researchers.

Bandichhor R, Borovik AS, Bettencourt-Dias A, Eastgate MD, Radu NS, Shi F, McElwee-White L.

Inorg Chem. 2023 Feb 13;62(6):2489-2493. doi: 10.1021/acs.inorgchem.3c00207. Epub 2023 Feb 2.

PMID: 36727951 

 

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab.

Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, Brahmer JR, Lawrence DP, Atkins MB, Powderly JD, Leming PD, Lipson EJ, Puzanov I, Smith DC, Taube JM, Wigginton JM, Kollia GD, Gupta A, Pardoll DM, Sosman JA, Hodi FS.

J Clin Oncol. 2023 Feb 10;41(5):943-954. doi: 10.1200/JCO.22.02272.

PMID: 36750016

 

In Support of Early-Career Researchers.

Bandichhor R, Borovik AS, Bettencourt-Dias A, Eastgate MD, Radu NS, Shi F, McElwee-White L.

Org Lett. 2023 Feb 10;25(5):715-719. doi: 10.1021/acs.orglett.3c00187. Epub 2023 Feb 2.

PMID: 36727953 

 

Cost-Effectiveness of Nivolumab Plus Ipilimumab for the First-Line Treatment of Intermediate/Poor-Risk Advanced and/or Metastatic Renal Cell Carcinoma in Switzerland.

Çakar E, Oniangue-Ndza C, Schneider RP, Klijn SL, Vogl UM, Rothermundt C, May JR.

Pharmacoecon Open. 2023 Feb 9. doi: 10.1007/s41669-023-00395-1. Online ahead of print

.PMID: 36757568 

 

Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.

Gillis EP, Parcella K, Bowsher M, Cook JH, Iwuagwu C, Naidu BN, Patel M, Peese K, Huang H, Valera L, Wang C, Kieltyka K, Parker DD, Simmermacher J, Arnoult E, Nolte RT, Wang L, Bender JA, Frennesson DB, Saulnier M, Wang AX, Meanwell NA, Belema M, Hanumegowda U, Jenkins S, Krystal M, Kadow JF, Cockett M, Fridell R.

J Med Chem. 2023 Feb 9;66(3):1941-1954. doi: 10.1021/acs.jmedchem.2c01732. Epub 2023 Jan 31.

PMID: 36719971

 

A Distributional Model of Bound Ligand Conformational Strain: From Small Molecules up to Large Peptidic Macrocycles.

Jain AN, Brueckner AC, Cleves AE, Reibarkh M, Sherer EC.

J Med Chem. 2023 Feb 9;66(3):1955-1971. doi: 10.1021/acs.jmedchem.2c01744. Epub 2023 Jan 26.

PMID: 36701387 

 

Experimental and computational characterization of mass transfer in high turndown bioreactors.

Schlaich EM, Thomas JA, Kandari L, Tremml G, Khetan A.

Biotechnol Prog. 2023 Feb 8:e3330. doi: 10.1002/btpr.3330. Online ahead of print.

PMID: 36751946

 

Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma.

Kurata K, James-Bott A, Tye MA, Yamamoto L, Samur MK, Tai YT, Dunford J, Johansson C, Senbabaoglu F, Philpott M, Palmer C, Ramasamy K, Gooding S, Smilova M, Gaeta G, Guo M, Christianson JC, Payne NC, Singh K, Karagoz K, Stokes ME, Ortiz M, Hagner P, Thakurta A, Cribbs A, Mazitschek R, Hideshima T, Anderson KC, Oppermann U.

Blood Cancer J. 2023 Feb 7;13(1):24. doi: 10.1038/s41408-023-00793-y.

PMID: 36746923 

 

Treatment patterns and outcomes among patients with small-cell lung cancer (SCLC) in Europe: a retrospective cohort study.

Blackhall F, Girard N, Livartowski A, McDonald L, Roset M, Lara N, Juarez García A.

BMJ Open. 2023 Feb 6;13(2):e052556. doi: 10.1136/bmjopen-2021-052556.

PMID: 36746549 

 

Measurement of LAG-3 Expression Across Multiple Staining Platforms With the 17B4 Antibody Clone.

Wojcik JB, Desai K, Avraam K, Vandebroek A, Dillon LM, Giacomazzi G, Rypens C, Benci JL.

Arch Pathol Lab Med. 2023 Feb 6. doi: 10.5858/arpa.2022-0082-OA. Online ahead of print.

PMID: 36745202 

 

Follow Your Nose: Repeat Nasal Bone Evaluation in First-Trimester Screening for Down Syndrome.

Miller KA, Sagaser KG, Hertenstein CB, Blakemore KJ, Forster KR, Lawson CS, Jelin AC.

J Ultrasound Med. 2023 Feb 6. doi: 10.1002/jum.16190. Online ahead of print.

PMID: 36744578

 

Amorphous Drug-Polymer Salts: Maximizing Proton Transfer to Enhance Stability and Release.

Neusaenger AL, Yao X, Yu J, Kim S, Hui HW, Huang L, Que C, Yu L.

Mol Pharm. 2023 Feb 6;20(2):1347-1356. doi: 10.1021/acs.molpharmaceut.2c00942. Epub 2023 Jan 20.

PMID: 36668815 

 

Declining enrolment and other challenges in IBD clinical trials: Causes and potential solutions.

Uzzan M, Bouhnik Y, Abreu M, Ahmad HA, Adsul S, Carlier H, Dubinsky M, Germinaro M, Jairath V, Modesto I, Mortensen E, Narula N, Neimark E, Oortwijn A, Protic M, Rubin DT, Oh YS, Wichary J, Peyrin-Biroulet L, Reinisch W.

J Crohns Colitis. 2023 Feb 4:jjad020. doi: 10.1093/ecco-jcc/jjad020. Online ahead of print.

PMID: 36738443

 

Structure-activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors.

Luo G, Chen L, Jacutin-Porte S, Han Y, Burton CR, Xiao H, Krause CM, Cao Y, Liu N, Kish K, Lewis HA, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2023 Feb 1;81:129143. doi: 10.1016/j.bmcl.2023.129143. Epub 2023 Jan 18.

PMID: 36669575

 

Treatment of muscle-invasive urothelial cancer with nivolumab (CheckMate 274 study): a plain language summary.

Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Antonio JN Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD.

Future Oncol. 2023 Feb;19(6):413-426. doi: 10.2217/fon-2022-1294. Epub 2023 Mar 15.

PMID: 36919916 

 

First-line nivolumab plus ipilimumab for metastatic non-small cell lung cancer, including patients with ECOG performance status 2 and other special populations: CheckMate 817.

Ready NE, Audigier-Valette C, Goldman JW, Felip E, Ciuleanu TE, Rosario García Campelo M, Jao K, Barlesi F, Bordenave S, Rijavec E, Urban L, Aucoin JS, Zannori C, Vermaelen K, Arén Frontera O, Curioni Fontecedro A, Sánchez-Gastaldo A, Juan-Vidal O, Linardou H, Poddubskaya E, Spigel DR, Ahmed S, Maio M, Li S, Chang H, Fiore J, Acevedo A, Paz-Ares L.

J Immunother Cancer. 2023 Feb;11(2):e006127. doi: 10.1136/jitc-2022-006127.

PMID: 36725084 

 

The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.

Prior H, Andrews L, Cauvin A, Chien H, Clarke DO, Datta K, Dempster M, Dybdal N, Freebern W, de Haan L, Herzyk D, Hey A, Kissner T, Kronenberg S, Leach MW, Lee D, Reid K, Schutte K, Sewell F, Trouba K, Ulrich P, van Aerts L, van Meer P, Weir L.

Regul Toxicol Pharmacol. 2023 Feb;138:105339. doi: 10.1016/j.yrtph.2023.105339. Epub 2023 Jan 14.

PMID: 36649820 

 

Improved benefit of continuing luspatercept therapy: sub-analysis of patients with lower-risk MDS in the MEDALIST study.

Germing U, Fenaux P, Platzbecker U, Buckstein R, Santini V, Díez-Campelo M, Yucel A, Tang D, Fabre S, Zhang G, Zoffoli R, Ha X, Miteva D, Hughes C, Komrokji RS, Zeidan AM, Garcia-Manero G.

Ann Hematol. 2023 Feb;102(2):311-321. doi: 10.1007/s00277-022-05071-8. Epub 2023 Jan 13.

PMID: 36635381

 

Development and Clinical Evaluation of a Rapid Point of Care Test for Ebola Virus Infection in Humans.

Wang Z, Bennett RS, Roehler M, Guillon G, Fischl MJ, Donadi MC, Makovetz J, Holmes N, Zaveri T, Toolan E, Gontz HL, Yearwood GD, Logue J, Bohannon JK, Mistretta L, Byrum R, Ragland D, St Claire M, Kurtz LA, Miller T, Reed MR, Young J, Lee J, Hensley LE, Kardos K, Berry JD.

Viruses. 2023 Jan 25;15(2):336. doi: 10.3390/v15020336.

PMID: 36851550 

 

Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury.

Guo Z, Valenzuela Ripoll C, Picataggi A, Rawnsley DR, Ozcan M, Chirinos JA, Chendamarai E, Girardi A, Riehl T, Evie H, Diab A, Kovacs A, Hyrc K, Ma X, Asnani A, Shewale SV, Scherrer-Crosbie M, Cowart LA, Parks JS, Zhao L, Gordon D, Ramirez-Valle F, Margulies KB, Cappola TP, Desai AA, Pedersen LN, Bergom C, Stitziel NO, Rettig MP, DiPersio JF, Hajny S, Christoffersen C, Diwan A, Javaheri A.

JACC Basic Transl Sci. 2023 Jan 4;8(3):340-355. doi: 10.1016/j.jacbts.2022.09.010. eCollection 2023 Mar.

PMID: 37034289 

 

Effect of pegbelfermin on NASH and fibrosis-related biomarkers and correlation with histological response in the FALCON 1 trial.

Brown EA, Minnich A, Sanyal AJ, Loomba R, Du S, Schwarz J, Ehman RL, Karsdal M, Leeming DJ, Cizza G, Charles ED.

JHEP Rep. 2023 Jan 7;5(4):100661. doi: 10.1016/j.jhepr.2022.100661. eCollection 2023 Apr.

PMID: 36866389 

 

Evaluating process utilities for the treatment burden of chemotherapy in multiple myeloma in Japan: a time trade-off valuation study.

Ishida T, Nakakoji M, Murata T, Matsuyama F, Iida S.

J Med Econ. 2023 Jan-Dec;26(1):565-573. doi: 10.1080/13696998.2023.2197811.

PMID: 37010489 

 

Long-term outcomes of stage IIB-IV melanoma patients: nationwide data from Norway.

Winge-Main A, Robsahm TE, Nyakas M, Festervoll G, Torkilseng E, Thybo S, Pati S, Carroll R.

Future Oncol. 2023 Jan;19(3):205-215. doi: 10.2217/fon-2022-0969. Epub 2023 Mar 28.

PMID: 36974621 

 

Neoadjuvant treatment and survival outcomes by pathologic complete response in HER2-negative early breast cancers.

Crosbie A, Le TK, Zhang Y, Das R, Ades F, Davis C, Gogate A.

Future Oncol. 2023 Jan;19(3):229-244. doi: 10.2217/fon-2022-0801. Epub 2023 Mar 28.

PMID: 36974619 

 

Caregiver survey in glioblastoma focused on cognitive dysfunction: development and results from a multicenter study.

Au TH, Willis C, Reblin M, Peters KB, Nghiemphu PL, Taylor JW, Colman H, Cohen AL, Ormond DR, Neil EC, Chakravarti A, Willmarth N, Balajonda BC, Menon J, Ma J, Bauer H, Nelson RS, Tan MS, Singh P, Marshall A, Korytowsky B, Stenehjem D, Brixner D.

Future Oncol. 2023 Jan;19(2):173-188. doi: 10.2217/fon-2022-0904. Epub 2023 Mar 28.

PMID: 36974606

 

In Vitro Generation of Human Cross-Presenting Type 1 Conventional Dendritic Cells (cDC1s) and Plasmacytoid Dendritic Cells (pDCs).

Luo X, Balan S, Arnold-Schrauf C, Dalod M.

Methods Mol Biol. 2023;2618:133-145. doi: 10.1007/978-1-0716-2938-3_10.

PMID: 36905514
 

Outcome following nivolumab treatment in patients with advanced non-small cell lung cancer and comorbid interstitial lung disease in a real-world setting.

Assié JB, Chouaïd C, Nunes H, Reynaud D, Gaudin AF, Grumberg V, Jolivel R, Jouaneton B, Cotté FE, Duchemann B.

Ther Adv Med Oncol. 2023 Jan 31;15:17588359231152847. doi: 10.1177/17588359231152847. eCollection 2023.

PMID: 36743523

 

Single-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients.

Huuhtanen J, Kasanen HH, Peltola K, Lönnberg T, Glumoff V, Brück O, Dufva O, Peltonen K, Vikkula J, Jokinen E, Ilander M, Lee MH, Mäkelä S, Nyakas M, Li B, Hernberg M, Bono P, Lähdesmäki H, Kreutzman A, Mustjoki S.

J Clin Invest. 2023 Jan 31:e164809. doi: 10.1172/JCI164809. Online ahead of print.

PMID: 36719749

 

Past, present and future of Focused Ultrasound as an adjunct or complement to DIPG/DMG therapy: A consensus of the 2021 FUSF DIPG meeting.

Parekh K, LeBlang S, Nazarian J, Mueller S, Zacharoulis S, Hynynen K, Powlovich L.

Neoplasia. 2023 Jan 27;37:100876. doi: 10.1016/j.neo.2023.100876. Online ahead of print.

PMID: 36709715

 

Clinical Outcomes, Resource Utilization, and Treatment Over the Disease Course of Symptomatic Obstructive Hypertrophic Cardiomyopathy in the United States.

Desai NR, Sutton MB, Xie J, Fine JT, Gao W, Owens AT, Naidu SS.

Am J Cardiol. 2023 Jan 27;192:16-23. doi: 10.1016/j.amjcard.2022.12.030. Online ahead of print.

PMID: 36709525

 

Paving the Road for CAR-Ts: ASTCT 80/20 Task Force consensus on challenges and solutions to improving efficiency of clinical center certification and maintenance of operations for commercially approved immune effector cell therapies.

Nikiforow S, Frigault MJ, Frey NV, Gardner RA, Komanduri KV, Perales MA, Kebriaei P, Warkentin PI, Pasquini M, Aho JL, Levine BL, Heslop HE, Hlucky TL, Habucky K, Gharibo M, Jagasia M, Locke FL.

Transplant Cell Ther. 2023 Jan 26:S2666-6367(23)00045-3. doi: 10.1016/j.jtct.2023.01.021. Online ahead of print.

PMID: 36709800

 

Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection.

Tawaraishi T, Ochida A, Akao Y, Itono S, Kamaura M, Akther T, Shimada M, Canan S, Chowdhury S, Cao Y, Condroski K, Engkvist O, Francisco A, Ghosh S, Kaki R, Kelly JM, Kimura C, Kogej T, Nagaoka K, Naito A, Pairaudeau G, Radu C, Roberts I, Shum D, Watanabe NA, Xie H, Yonezawa S, Yoshida O, Yoshida R, Mowbray C, Perry B.

J Med Chem. 2023 Jan 26;66(2):1221-1238. doi: 10.1021/acs.jmedchem.2c00775. Epub 2023 Jan 6.

PMID: 36607408

 

Rapid Sterility Test Systems in the Pharmaceutical Industry: Applying a Structured Approach to their Evaluation, Validation and Global Implementation.

Deutschmann S, Paul M, Claassen-Willemse M, van den Berg J, IJzerman-Boon P, Grunert da Fonseca V, Brunbech E, Johnson L, Knutsen C, Plourde L, Salvas J, Villari P, Wysocki L, Franz-Riethdorf M.

PDA J Pharm Sci Technol. 2023 Jan 25:pdajpst.2021.012672. doi: 10.5731/pdajpst.2021.012672. Online ahead of print.

PMID: 36697213

 

Recent advances in the in vitro and in vivo methods to assess impact of P-glycoprotein and breast cancer resistance protein transporters in central nervous system drug disposition.

Chatterjee S, Deshpande AA, Shen H.

Biopharm Drug Dispos. 2023 Jan 24. doi: 10.1002/bdd.2345. Online ahead of print.

PMID: 36692150

 

Sequencing antigen-targeting antibodies and cellular therapies in adults with relapsed/refractory B-cell acute lymphoblastic leukemia.

Aldoss I, Shah BD, Park JH, Muffly L, Logan AC, Brown P, Stock W, Jabbour EJ.

Am J Hematol. 2023 Jan 24. doi: 10.1002/ajh.26853. Online ahead of print.

PMID: 36691748 

 

 

Phase 2 results of idecabtagene vicleucel (ide-cel, bb2121) in Japanese patients with relapsed and refractory multiple myeloma.

Minakata D, Ishida T, Ando K, Suzuki R, Tanaka J, Hagiwara S, Ananthakrishnan R, Kuwayama S, Nishio M, Kanda Y, Suzuki K.

Int J Hematol. 2023 Jan 24. doi: 10.1007/s12185-023-03538-6. Online ahead of print.

PMID: 36690910

 

Correction to: Individual Case Safety Report Replication: An Analysis of Case Reporting Transmission Networks.

van Stekelenborg J, Kara V, Haack R, Vogel U, Garg A, Krupp M, Gofman K, Dreyfus B, Hauben M, Bate A.

Drug Saf. 2023 Jan 23. doi: 10.1007/s40264-023-01272-w. Online ahead of print.

PMID: 36689132

 

A consensus viewpoint on the role of direct factor Xa inhibitors in the management of cancer-associated venous thromboembolism in the UK.

Cohen AT, Benson G, Bradbury CA, Choudhuri S, Hutchinson Jones N, Maraveyas A, Venugopal B, Young AM, Chapman C, McIntyre S, Burney D, Pollock KG, Morgan AR, Gabb PD, Alikhan R.

Curr Med Res Opin. 2023 Jan 23:1-13. doi: 10.1080/03007995.2023.2167441. Online ahead of print.

PMID: 36629478 Review.

 

Assessing the Impact of Open-Label Designs in Patient-Reported Outcomes: Investigation in Oncology Clinical Trials.

Lord-Bessen J, Signorovitch J, Yang M, Georgieva M, Roydhouse J.

JNCI Cancer Spectr. 2023 Jan 20:pkad002. doi: 10.1093/jncics/pkad002. Online ahead of print.

PMID: 36661326

 

Long-term survival with oral azacitidine for patients with acute myeloid leukemia in first remission after chemotherapy: Updated results from the randomized, placebo-controlled, phase 3 QUAZAR AML-001 trial.

Wei AH, Döhner H, Sayar H, Ravandi F, Montesinos P, Dombret H, Selleslag D, Porkka K, Jang JH, Skikne B, Beach CL, Prebet T, Zhang G, Risueño A, Ugidos M, See WL, Menezes D, Roboz GJ.

Am J Hematol. 2023 Jan 19. doi: 10.1002/ajh.26847. Online ahead of print.

PMID: 36655608

 

A fast and powerful linear mixed model approach for genotype-environment interaction tests in large-scale GWAS.

Zhong W, Chhibber A, Luo L, Mehrotra DV, Shen J.

Brief Bioinform. 2023 Jan 19;24(1):bbac547. doi: 10.1093/bib/bbac547.

PMID: 36545787

 

Effects of Mavacamten on Measures of Cardiopulmonary Exercise Testing Beyond Peak Oxygen Consumption: A Secondary Analysis of the EXPLORER-HCM Randomized Trial.

Wheeler MT, Olivotto I, Elliott PM, Saberi S, Owens AT, Maurer MS, Masri A, Sehnert AJ, Edelberg JM, Chen YM, Florea V, Malhotra R, Wang A, Oreziak A, Myers J.

JAMA Cardiol. 2023 Jan 18:e225099. doi: 10.1001/jamacardio.2022.5099. Online ahead of print.

PMID: 36652223

 

Phosphine-Dependent Photoinitiation of Alkyl Thiols under Near-UV Light Facilitates User-Friendly Peptide Desulfurization.

Venneti NM, Samala G, Morsy RMI, Mendoza LG, Isidro-Llobet A, Tom JK, Mukherjee S, Kopach ME, Stockdill JL.

J Am Chem Soc. 2023 Jan 18;145(2):1053-1061. doi: 10.1021/jacs.2c10625. Epub 2023 Jan 5.

PMID: 36602440

 

Authentication of Human and Mouse Cell Lines by Short Tandem Repeat (STR) DNA Genotype Analysis.

Almeida JL, Korch CT.

2023 Jan 17. In: Markossian S, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Haas JV, Hall MD, Hoare S, Inglese J, Iversen PW, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Saradjian P, Sittampalam GS, Tarselli M, Trask OJ Jr, Wang Y, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–.

PMID: 23805434

 

Real-world Retention and Clinical Effectiveness of Secukinumab for Axial Spondyloarthritis: Results from the CanSpA Research Network.

Inman RD, Choquette D, Khraishi M, Gladman D, Hussein S, Neish D, Leclerc P.

J Rheumatol. 2023 Jan 15:jrheum.220824. doi: 10.3899/jrheum.220824. Online ahead of print.

PMID: 36642434

 

Baseline radiomic signature to estimate overall survival in patients with non-small cell lung cancer.

Dercle L, Fronheiser M, Rizvi NA, Hellmann MD, Maier S, Hayes W, Yang H, Guo P, Fojo T, Schwartz LH, Zhao B, Leung DK.

J Thorac Oncol. 2023 Jan 13:S1556-0864(22)01995-5. doi: 10.1016/j.jtho.2022.12.019. Online ahead of print.

PMID: 36646209

 

Evolution of treatment patterns and survival outcomes in patients with advanced non-small cell lung cancer treated at Frankfurt University Hospital in 2012-2018.

Wolf A, Stratmann JA, Shaid S, Niklas N, Calleja A, Ubhi H, Munro R, Waldenberger D, Carroll R, Daumont MJ, Penrod JR, Lacoin L, Rohde G.

BMC Pulm Med. 2023 Jan 13;23(1):16. doi: 10.1186/s12890-022-02288-1.

PMID: 36639770

 

A Novel BCMA Immunohistochemistry Assay Reveals a Heterogenous and Dynamic BCMA Expression Profile in Multiple Myeloma.

Zhang M, Gray F, Cushman I, Wurmser A, Chan H, Couto S, Wang M, Nakayama Y, Hagner P, Al-Masri H, Williams S, Hersey S.

Mod Pathol. 2023 Jan 12;36(4):100050. doi: 10.1016/j.modpat.2022.100050. Online ahead of print.

PMID: 36788077

 

Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma.

Kurata K, James-Bott A, Tye MA, Yamamoto L, Samur MK, Tai YT, Dunford J, Johansson C, Senbabaoglu F, Philpott M, Palmer C, Ramasamy K, Gooding S, Smilova M, Gaeta G, Guo M, Christianson JC, Payne NC, Singh K, Karagoz K, Stokes ME, Ortiz M, Hagner P, Thakurta A, Cribbs A, Mazitschek R, Hideshima T, Anderson KC, Oppermann U.

Blood Cancer J. 2023 Jan 12;13(1):12. doi: 10.1038/s41408-023-00787-w.

PMID: 36631435

 

Correction: End-to-End Approach to Surfactant Selection, Risk Mitigation, and Control Strategies for Protein-Based Therapeutics.

Morales AM, Sreedhara A, Buecheler J, Brosig S, Chou D, Christian T, Das T, de Jong I, Fast J, Jagannathan B, Moussa EM, Nejadnik MR, Prajapati I, Radwick A, Rahman Y, Singh S.

AAPS J. 2023 Jan 11;25(1):15. doi: 10.1208/s12248-023-00780-y.

PMID: 36631711

 

Trends in direct oral anticoagulant (DOAC) prescribing in English primary care (2014-2019).

Joy M, Williams J, Emanuel S, Kar D, Fan X, Delanerolle G, Field BC, Heiss C, Pollock KG, Sandler B, Arora J, Sheppard JP, Feher M, Hobbs FR, de Lusignan S.

Heart. 2023 Jan 11;109(3):195-201. doi: 10.1136/heartjnl-2022-321377.

PMID: 36371664

 

FDA/M-CERSI Co-Processed API Workshop Proceedings.

Schenck L, Patel P, Sood R, Bonaga L, Capella P, Dirat O, Erdemir D, Ferguson S, Gazziola C, Gorka LS, Graham L, Ho R, Hoag S, Hunde E, Kline B, Lee SL, Madurawe R, Marziano I, Merritt JM, Page S, Polli J, Ramanadham M, Sapru M, Stevens B, Watson T, Zhang H.

J Pharm Sci. 2023 Jan 10:S0022-3549(23)00007-2. doi: 10.1016/j.xphs.2023.01.006. Online ahead of print.

PMID: 36638959

 

Understanding the Impact of Microstructures on Reconstitution and Drying Kinetics of Lyophilized Cake Using X-ray Microscopy and Image-Based Simulation.

Pu YE, Ma L, Dear B, Zhu A, Li J, Zhang S, Shi W.

J Pharm Sci. 2023 Jan 7:S0022-3549(23)00004-7. doi: 10.1016/j.xphs.2023.01.002. Online ahead of print.

PMID: 36627053

 

Emulating Randomized Controlled Trials with Hybrid Control Arms in Oncology: A Case Study.

Sengupta S, Ntambwe I, Tan K, Liang Q, Paulucci D, Castellanos E, Fiore J, Lane S, Micsinai Balan M, Viraswami-Apanna K, Sethuraman V, Samant M, Tiwari R.

Clin Pharmacol Ther. 2023 Jan 6. doi: 10.1002/cpt.2841. Online ahead of print.

PMID: 36606735

 

The burden of red blood cell transfusions in patients with lower-risk myelodysplastic syndromes and ring sideroblasts: an analysis of the prospective MDS-CAN registry.

Buckstein R, Chodirker L, Yee KWL, Geddes M, Leitch HA, Christou G, Banerji V, Leber B, Khalaf D, St-Hilaire E, Finn N, Nevill T, Keating MM, Storring J, Parmentier A, Thambipillai A, Tang D, Westcott C, Cameron C, Spin P.

Leuk Lymphoma. 2023 Jan 6:1-11. doi: 10.1080/10428194.2022.2156793. Online ahead of print.

PMID: 36606533

 

Coupling-Condensation Strategy for the Convergent Synthesis of an Imidazole-Fused 2-Aminoquinoline NLRP3 Agonist.

Bi C, Chadwick J, Davies ML, DelMonte AJ, Geng P, Glace AW, Green RA, Gurak JA Jr, Haley MW, He BL, Inankur B, Jamison CR, Joe CL, Kolotuchin S, Lin D, Lou S, Nye J, Ortiz A, Purdum GE, Rosso VW, Shah M, Simmons EM, Stevens JM, Strotman NA, Tan Y, Zhang L.

J Org Chem. 2023 Jan 6;88(1):384-394. doi: 10.1021/acs.joc.2c02395. Epub 2022 Dec 14.

PMID: 36516991

 

Treatment of De Novo Renal Transplant Recipients With Calcineurin Inhibitor-free, Belatacept Plus Everolimus-based Immunosuppression.

Peddi VR, Marder B, Gaite L, Oberholzer J, Goldberg R, Pearson T, Yang H, Allamassey L, Polinsky M, Formica RN.

Transplant Direct. 2023 Jan 6;9(2):e1419. doi: 10.1097/TXD.0000000000001419. eCollection 2023 Feb.

PMID: 36700062

 

A Cartographic Tool to Predict Disease Risk-associated Pseudo-Dynamic Networks from Tissue-specific Gene Expression.

Chen C, Shen B, Zhang L, Yu T, Wang M, Wu R.

Bio Protoc. 2023 Jan 5;13(1):e4583. doi: 10.21769/BioProtoc.4583. eCollection 2023 Jan 5.

PMID: 36789091 

 

Understanding the Association between Red Blood Cell Transfusion Utilization and Humanistic and Economic Burden in Patients with β-Thalassemia from the Patients' Perspective.

Knoth RL, Gupta S, Perkowski K, Costantino H, Inyart B, Ashka L, Clapp K.

J Clin Med. 2023 Jan 4;12(2):414. doi: 10.3390/jcm12020414.

PMID: 36675342 

 

Regulatory utility of physiologically based pharmacokinetic modeling for assessing food impact in bioequivalence studies: A workshop summary report.

Al Shoyaib A, Riedmaier AE, Kumar A, Roy P, Parrott NJ, Fang L, Tampal N, Yang Y, Jereb R, Zhao L, Wu F.

CPT Pharmacometrics Syst Pharmacol. 2023 Jan 3. doi: 10.1002/psp4.12913. Online ahead of print.

PMID: 36597353 

 

The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2.

Vierbuchen T, Agarwal S, Johnson JL, Galia L, Lei X, Stein K, Olagnier D, Gaede KI, Herzmann C, Holm CK, Heine H, Pai A, O'Hara Hall A, Hoebe K, Fitzgerald KA.

Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2213715120. doi: 10.1073/pnas.2213715120. Epub 2022 Dec 28.

PMID: 36577072

 

Exploration of Tumor Biopsy Gene Signatures to Understand the Role of the Tumor Microenvironment in Outcomes to Lisocabtagene Maraleucel.

Olson NE, Ragan SP, Reiss DJ, Thorpe J, Kim Y, Abramson JS, McCoy C, Newhall KJ, Fox BA.

Mol Cancer Ther. 2023 Jan 3:MCT-21-0506. doi: 10.1158/1535-7163.MCT-21-0506. Online ahead of print.

PMID: 36595660

 

Association of Body Mass Index With the Safety Profile of Nivolumab With or Without Ipilimumab.

McQuade JL, Hammers H, Furberg H, Engert A, André T, Blumenschein G Jr, Tannir N, Baron A, Larkin J, El-Khoueiry A, Carbone DP, Thomas JM, Hennicken D, Coffey M, Motzer RJ.

JAMA Oncol. 2023 Jan 1;9(1):102-111. doi: 10.1001/jamaoncol.2022.5409.

PMID: 36480191

 

Trends in Disease Severity Among Critically Ill Children With Severe Acute Respiratory Syndrome Coronavirus 2: A Retrospective Multicenter Cohort Study in the United States.

Ross CE, Burns JP, Grossestreuer AV, Bhattarai P, McKiernan CA, Franks JD, Lehmann S, Sorcher JL, Sharron MP, Wai K, Al-Wahab H, Boukas K, Hall MW, Ru G, Sen AI, Rajasekhar HR, Kleinman LC, McGuire JK, Arrington AS, Munoz-Rivas F, Osborne CM, Shekerdemian LS.

Pediatr Crit Care Med. 2023 Jan 1;24(1):25-33. doi: 10.1097/PCC.0000000000003105. Epub 2022 Nov 17.

PMID: 36516349 

 

Venous thromboembolism incidence and risk factors associated with immune checkpoint inhibitors among patients with advanced non-small cell lung cancer.

Khorana AA, Palaia J, Rosenblatt L, Pisupati R, Huang N, Nguyen C, Barron J, Gallagher K, Bond TC.

J Immunother Cancer. 2023 Jan;11(1):e006072. doi: 10.1136/jitc-2022-006072.

PMID: 36657815

 

Individual Case Safety Report Replication: An Analysis of Case Reporting Transmission Networks.

van Stekelenborg J, Kara V, Haack R, Vogel U, Garg A, Krupp M, Gofman K, Dreyfus B, Hauben M, Bate A.

Drug Saf. 2023 Jan;46(1):39-52. doi: 10.1007/s40264-022-01251-7. Epub 2022 Dec 24.

PMID: 36565374 

 

The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer.

Pafiakis A, Armenante P, Gogos CG.

Pharm Dev Technol. 2023 Jan;28(1):1-17. doi: 10.1080/10837450.2022.2156539. Epub 2022 Dec 30.

PMID: 36533900

  

Patient-Reported Distress and Clinical Outcomes with Immuno-Oncology Agents in Metastatic Non-Small Cell Lung Cancer (mNSCLC): A Real-World Retrospective Cohort Study.

Bodd MH, Locke SC, Wolf SP, Antonia S, Crawford J, Hartman J, Herring KW, Ready NE, Stinchcombe TE, Troy JD, Williams C, Clarke JM, LeBlanc TW.

Lung Cancer. 2023 Jan;175:17-26. doi: 10.1016/j.lungcan.2022.11.010. Epub 2022 Nov 21.

PMID: 36442383

 

Prognostic implications of mono-hit and multi-hit TP53 alterations in patients with acute myeloid leukemia and higher risk myelodysplastic syndromes treated with azacitidine-based therapy.

Zeidan AM, Bewersdorf JP, Hasle V, Shallis RM, Thompson E, de Menezes DL, Rose S, Boss I, Halene S, Haferlach T, Fox B.

Leukemia. 2023 Jan;37(1):240-243. doi: 10.1038/s41375-022-01766-z. Epub 2022 Nov 27.

PMID: 36437356 

 

Economic Burden of Comorbidities in Patients with Psoriasis in the USA.

Wu JJ, Suryavanshi M, Davidson D, Patel V, Jain A, Seigel L.

Dermatol Ther (Heidelb). 2023 Jan;13(1):207-219. doi: 10.1007/s13555-022-00832-9. Epub 2022 Nov 19.

PMID: 36402940 

 

Improvements to in silico skin sensitisation predictions through privacy-preserving data sharing.

Macmillan DS, Chilton ML, Hillegass J.

Regul Toxicol Pharmacol. 2023 Jan;137:105292. doi: 10.1016/j.yrtph.2022.105292. Epub 2022 Nov 15.

PMID: 36400282 

 

Mass spectrometry in gene therapy: Challenges and opportunities for AAV analysis.

Serrano MAC, Furman R, Chen G, Tao L.

Drug Discov Today. 2023 Jan;28(1):103442. doi: 10.1016/j.drudis.2022.103442. Epub 2022 Nov 14.

PMID: 36396118

 

First-in-human study of deucravacitinib: A selective, potent, allosteric small-molecule inhibitor of tyrosine kinase 2.

Catlett IM, Aras U, Hansen L, Liu Y, Bei D, Girgis IG, Murthy B.

Clin Transl Sci. 2023 Jan;16(1):151-164. doi: 10.1111/cts.13435. Epub 2022 Nov 22.

PMID: 36325947

 

FinnGen provides genetic insights from a well-phenotyped isolated population.

Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, Loukola A, Lahtela E, Mattsson H, Laiho P, Della Briotta Parolo P, Lehisto AA, Kanai M, Mars N, Rämö J, Kiiskinen T, Heyne HO, Veerapen K, Rüeger S, Lemmelä S, Zhou W, Ruotsalainen S, Pärn K, Hiekkalinna T, Koskelainen S, Paajanen T, Llorens V, Gracia-Tabuenca J, Siirtola H, Reis K, Elnahas AG, Sun B, Foley CN, Aalto-Setälä K, Alasoo K, Arvas M, Auro K, Biswas S, Bizaki-Vallaskangas A, Carpen O, Chen CY, Dada OA, Ding Z, Ehm MG, Eklund K, Färkkilä M, Finucane H, Ganna A, Ghazal A, Graham RR, Green EM, Hakanen A, Hautalahti M, Hedman ÅK, Hiltunen M, Hinttala R, Hovatta I, Hu X, Huertas-Vazquez A, Huilaja L, Hunkapiller J, Jacob H, Jensen JN, Joensuu H, John S, Julkunen V, Jung M, Junttila J, Kaarniranta K, Kähönen M, Kajanne R, Kallio L, Kälviäinen R, Kaprio J; FinnGen; Kerimov N, Kettunen J, Kilpeläinen E, Kilpi T, Klinger K, Kosma VM, Kuopio T, Kurra V, Laisk T, Laukkanen J, Lawless N, Liu A, Longerich S, Mägi R, Mäkelä J, Mäkitie A, Malarstig A, Mannermaa A, Maranville J, Matakidou A, Meretoja T, Mozaffari SV, Niemi MEK, Niemi M, Niiranen T, O Donnell CJ, Obeidat ME, Okafo G, Ollila HM, Palomäki A, Palotie T, Partanen J, Paul DS, Pelkonen M, Pendergrass RK, Petrovski S, Pitkäranta A, Platt A, Pulford D, Punkka E, Pussinen P, Raghavan N, Rahimov F, Rajpal D, Renaud NA, Riley-Gillis B, Rodosthenous R, Saarentaus E, Salminen A, Salminen E, Salomaa V, Schleutker J, Serpi R, Shen HY, Siegel R, Silander K, Siltanen S, Soini S, Soininen H, Sul JH, Tachmazidou I, Tasanen K, Tienari P, Toppila-Salmi S, Tukiainen T, Tuomi T, Turunen JA, Ulirsch JC, Vaura F, Virolainen P, Waring J, Waterworth D, Yang R, Nelis M, Reigo A, Metspalu A, Milani L, Esko T, Fox C, Havulinna AS, Perola M, Ripatti S, Jalanko A, Laitinen T, Mäkelä TP, Plenge R, McCarthy M, Runz H, Daly MJ, Palotie A.

Nature. 2023 Jan;613(7944):508-518. doi: 10.1038/s41586-022-05473-8. Epub 2023 Jan 18.

PMID: 36653562

 

Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction.

Qiu J, Xu B, Ye D, Ren D, Wang S, Benci JL, Xu Y, Ishwaran H, Beltra JC, Wherry EJ, Shi J, Minn AJ.

Nat Cancer. 2023 Jan;4(1):43-61. doi: 10.1038/s43018-022-00490-y. Epub 2023 Jan 16.

PMID: 36646856

 

Probing the effect of glycosaminoglycan depletion on integrin interactions with collagen I fibrils in the native extracellular matrix environment.

Roth J, Hoop CL, Williams JK, Hayes R, Baum J.

Protein Sci. 2023 Jan;32(1):e4508. doi: 10.1002/pro.4508.

PMID: 36369695

 

Cost-effectiveness of idecabtagene vicleucel compared with conventional care in triple-class exposed relapsed/refractory multiple myeloma patients in Canada and France.

Karampampa K, Zhang W, Venkatachalam M, Cotte FE, Dhanda D.

J Med Econ. 2023 Jan-Dec;26(1):243-253. doi: 10.1080/13696998.2023.2173466.

PMID: 36705644 

 

Warfarin Time in Therapeutic INR Range and Direct Oral Anticoagulant Adherence for Venous Thromboembolism Across the Spectrum of Weight and Body Mass Index: Findings from Veterans Health Administration.

Din N, Fan J, Schmitt S, Guo JD, Hlavacek P, Pundi K, Russ C, Emir B, Turakhia MP, Perino AC.

Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231152474. doi: 10.1177/10760296231152474.

PMID: 36694957

Safety and tolerability of KarXT (xanomeline-trospium) in a phase 2, randomized, double-blind, placebo-controlled study in patients with schizophrenia.

Correll CU, Angelov AS, Miller AC, Weiden PJ, Brannan SK.Schizophrenia (Heidelb). 2022 Dec 3;8(1):109. doi: 10.1038/s41537-022-00320-1.PMID: 36463237 

 

A hidden Markov modeling approach combining objective measure of activity and subjective measure of self-reported sleep to estimate the sleep-wake cycle.

Ogbagaber SB, Cui Y, Li K, Iannotti RJ, Albert PS.

J Appl Stat. 2022 Dec 1;51(2):370-387. doi: 10.1080/02664763.2022.2151576. eCollection 2024.

PMID: 38283049

 

Muscarinic acetylcholine receptors for psychotic disorders: bench-side to clinic.

Yohn SE, Weiden PJ, Felder CC, Stahl SM.

Trends Pharmacol Sci. 2022 Dec;43(12):1098-1112. doi: 10.1016/j.tips.2022.09.006.

Epub 2022 Oct 20.PMID: 36273943

 

Effectiveness of KarXT (xanomeline-trospium) for cognitive impairment in schizophrenia: post hoc analyses from a randomised, double-blind, placebo-controlled phase 2 study.

Sauder C, Allen LA, Baker E, Miller AC, Paul SM, Brannan SK.

Transl Psychiatry. 2022 Nov 21;12(1):491. doi: 10.1038/s41398-022-02254-9.

PMID: 36414626  Clinical Trial.

 

Cost-effectiveness of atrial fibrillation screening in Canadian community practice.

Andrade JG, Shah A, Godin R, Lanitis T, Kongnakorn T, Brown L, Dhanda D, Dhamane A, Nault I.

Heart Rhythm O2. 2022 Nov 17;4(2):103-110. doi: 10.1016/j.hroo.2022.11.003. eCollection 2023 Feb.

PMID: 36873310

 

Accuracy and Safety of Novel Designs for Phase I Drug-Combination Oncology Trials.

Liu R, Yuan Y, Sen S, Yang X, Jiang Q, Li XN, Lu CC, Göneng M, Tian H, Zhou H, Lin R, Marchenko O.

Stat Biopharm Res. 2022;14(3):270-282. doi: 10.1080/19466315.2022.2081602. Epub 2022 Aug 2.

PMID: 37275462

 

Adverse events and clinical outcomes in patients treated with PD-(L)1 blockade for advanced non-small-cell lung cancer.

Zhang Y, Doran C, Le TK, Dreyfus B, Kola N, Sylvester BE, Lal L, Penrod JR, Meadows Shropshire S.

Future Oncol. 2022 Dec;18(40):4509-4523. doi: 10.2217/fon-2022-1117. Epub 2023 Mar 21.

PMID: 36942686 

 

PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell.

Bergman D, Marazzi L, Chowkwale M, Maheshvare M D, Bidanta S, Mapder T, Li J.

GigaByte. 2022 Nov 30;2022:gigabyte72. doi: 10.46471/gigabyte.72. eCollection 2022.

PMID: 36950142 

 

Principles and Procedures for Assessment of Acute Toxicity Incorporating In Silico Methods.

Zwickl CM, Graham J, Jolly R, Bassan A, Ahlberg E, Amberg A, Anger LT, Barton-Maclaren T, Beilke L, Bellion P, Brigo A, Cronin MTD, Custer L, Devlin A, Burleigh-Flayers H, Fish T, Glover K, Glowienke S, Gromek K, Jones D, Karmaus A, Kemper R, Piparo EL, Madia F, Martin M, Masuda-Herrera M, McAtee B, Mestre J, Milchak L, Moudgal C, Mumtaz M, Muster W, Neilson L, Patlewicz G, Paulino A, Roncaglioni A, Ruiz P, Suarez D, Szabo DT, Valentin JP, Vardakou I, Woolley D, Myatt G.

Comput Toxicol. 2022 Nov;24:100237. doi: 10.1016/j.comtox.2022.100237. Epub 2022 Jul 14.

PMID: 36818760

 

The CCL2 rs4586 SNP Is Associated with Slower Amyloid-β Deposition and Faster Tau Accumulation of Alzheimer's Disease.

Gao F, Zhang PF, Gao J, Song J, Chi S; Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2022;90(4):1647-1657. doi: 10.3233/JAD-220716.

PMID: 36314210

 

Network-based assessment of HDAC6 activity predicts preclinical and clinical responses to the HDAC6 inhibitor ricolinostat in breast cancer.

Zeleke TZ, Pan Q, Chiuzan C, Onishi M, Li Y, Tan H, Alvarez MJ, Honan E, Yang M, Chia PL, Mukhopadhyay P, Kelly S, Wu R, Fenn K, Trivedi MS, Accordino M, Crew KD, Hershman DL, Maurer M, Jones S, High A, Peng J, Califano A, Kalinsky K, Yu J, Silva J.

Nat Cancer. 2022 Dec 30. doi: 10.1038/s43018-022-00489-5. Online ahead of print.

PMID: 36585452

 

Evaluation of the outcomes of newly diagnosed patients with high-risk myelodysplastic syndrome according to the initial therapeutical strategies chosen in usual clinical practice.

Montoro MJ, Pomares H, Coll R, Bernal Del Castillo T, Tormo M, Jiménez A, Brunet S, Casaño J, Oiartzabal I, Díez-Campelo M, Ramos F, Romero R, Salido-Fiérrez E, Pedro C, Bargay J, Muñoz-Novas C, López R, Rafel M, Valcárcel D; ERASME study group.

Leuk Lymphoma. 2022 Dec 28:1-12. doi: 10.1080/10428194.2022.2154604. Online ahead of print.

PMID: 36577016

 

Imaging Non-alcoholic Fatty Liver Disease Model Using H-1 and F-19 MRI.

Lister D, Blizard G, Hosseini M, Messer K, Wellen J, Sirlin CB, Ahrens ET.

Mol Imaging Biol. 2022 Dec 27. doi: 10.1007/s11307-022-01798-y. Online ahead of print.

PMID: 36575339

 

Analyzing dental fluorosis data using a novel Bayesian model for clustered longitudinal ordinal outcomes with an inflated category.

Kang T, Gaskins J, Levy S, Datta S.

Stat Med. 2022 Dec 27. doi: 10.1002/sim.9641. Online ahead of print.

PMID: 36574753

 

The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1.

Haddad Derafshi B, Danko T, Chanda S, Batista PJ, Litzenburger U, Lee QY, Ng YH, Sebin A, Chang HY, Südhof TC, Wernig M.

Sci Rep. 2022 Dec 27;12(1):22425. doi: 10.1038/s41598-022-23614-x.

PMID: 36575212 

 

Effectiveness of taxanes following nivolumab in patients with advanced esophageal squamous cell carcinoma: a retrospective chart review of patients in ATTRACTION-3.

Chin K, Yamamoto S, Takahashi M, Kadowaki S, Kubota Y, Amanuma Y, Okada M, Kanda M, Kimura Y, Nogi Y, Arimitsu Y, Kitagawa Y.

Esophagus. 2022 Dec 23. doi: 10.1007/s10388-022-00972-z. Online ahead of print.

PMID: 36564602

 

Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor.

Perera V, Wang Z, Lubin S, Christopher LJ, Chen W, Xu S, Seiffert D, DeSouza M, Murthy B.

Sci Rep. 2022 Dec 23;12(1):22239. doi: 10.1038/s41598-022-25936-2.

PMID: 36564395

 

Nivolumab, Brentuximab Vedotin, +/- Bendamustine For R/R Hodgkin Lymphoma in Children, Adolescents, and Young Adults.

Harker-Murray P, Mauz-Körholz C, Leblanc TM, Mascarin M, Michel G, Cooper S, Beishuizen A, Leger KJ, Amoroso L, Buffardi S, Rigaud C, Hoppe BS, Lisano JM, Francis S, Sacchi M, Cole PD, Drachtman RA, Kelly KM, Daw S.

Blood. 2022 Dec 23:blood.2022017118. doi: 10.1182/blood.2022017118. Online ahead of print.

PMID: 36564047

 

A single-arm phase 2 trial of Sitravatinib in advanced well-differentiated/dedifferentiated liposarcoma.

Ingham M, Lee S, Van Tine BA, Choy E, Oza J, Doshi S, Ge L, Oppelt P, Cote G, Corgiat B, Sender N, Sta Ana S, Panchalingam L, Petricoin E, Schwartz GK.

Clin Cancer Res. 2022 Dec 22:CCR-22-3351. doi: 10.1158/1078-0432.CCR-22-3351. Online ahead of print.

PMID: 36548343

 

Design of paediatric trials with benefit-risk endpoints using a composite score of adverse events of interest (AEI) and win-statistics.

Seifu Y, Mt-Isa S, Duke K, Gamalo-Siebers M, Wang W, Dong G, Kolassa J.

J Biopharm Stat. 2022 Dec 22:1-12. doi: 10.1080/10543406.2022.2153202. Online ahead of print.

PMID: 36545791

 

Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of phase 3 TRANSFORM study.

Abramson JS, Solomon SR, Arnason JE, Johnston PB, Glass B, Bachanova V, Ibrahimi S, Mielke S, Mutsaers PGNJ, Hernandez-Ilizaliturri FJ, Izutsu K, Morschhauser F, Lunning MA, Crotta A, Montheard S, Previtali A, Ogasawara K, Kamdar M.

Blood. 2022 Dec 21:blood.2022018730. doi: 10.1182/blood.2022018730. Online ahead of print.

PMID: 36542826

 

Dysphagia Days as an Assessment of Clinical Treatment Outcome in Eosinophilic Esophagitis.

Hirano I, Rothenberg ME, Zhang S, de Oliveira C, Charriez CM, Coyne KS, Bacci ED, Dellon ES.

Am J Gastroenterol. 2022 Dec 20. doi: 10.14309/ajg.0000000000002094. Online ahead of print.

PMID: 36647838

 

Correction to: Nivolumab versus placebo as adjuvant therapy for resected stage III melanoma: a propensity weighted indirect treatment comparison and number needed to treat analysis for recurrence-free survival and overall survival.

Weber JS, Poretta T, Stwalley BD, Sakkal LA, Du EX, Wang T, Chen Y, Wang Y, Betts KA, Shoushtari AN.

Cancer Immunol Immunother. 2022 Dec 20. doi: 10.1007/s00262-022-03351-w. Online ahead of print.

PMID: 36538061

 

Using Digestion by IdeS Protease to Improve Quantification of Degradants in Monoclonal Antibodies by Non-Reducing Capillary Gel Electrophoresis.

McClain A, Zhang Y, Yin Y, Wang Q, Hwang LY, Gu Y, Beckman J, Ludwig R.

Anal Chem. 2022 Dec 20;94(50):17388-17395. doi: 10.1021/acs.analchem.2c02630. Epub 2022 Dec 6.

PMID: 36472948

 

Effect of solution condition on the binding behaviors of monoclonal antibody and fusion protein therapeutics in Protein A chromatography.

Guo J, Noyes S, Jin W, Curtis H, Xu X, Ghose S.

J Chromatogr A. 2022 Dec 20;1686:463652. doi: 10.1016/j.chroma.2022.463652. Epub 2022 Nov 16.

PMID: 36434831

 

Effectiveness and Safety of Direct Oral Anticoagulants Among Patients with Non-valvular Atrial Fibrillation and Multimorbidity.

Dhamane AD, Ferri M, Keshishian A, Russ C, Atreja N, Gutierrez C, Emir B, Yuce H, Di Fusco M.

Adv Ther. 2022 Dec 17. doi: 10.1007/s12325-022-02387-9. Online ahead of print.

PMID: 36527598

 

Adjuvant nab-Paclitaxel + Gemcitabine in Resected Pancreatic Ductal Adenocarcinoma: Results From a Randomized, Open-Label, Phase III Trial.

Tempero MA, Pelzer U, O'Reilly EM, Winter J, Oh DY, Li CP, Tortora G, Chang HM, Lopez CD, Bekaii-Saab T, Ko AH, Santoro A, Park JO, Noel MS, Frassineti GL, Shan YS, Dean A, Riess H, Van Cutsem E, Berlin J, Philip P, Moore M, Goldstein D, Tabernero J, Li M, Ferrara S, Le Bruchec Y, Zhang G, Lu B, Biankin AV, Reni M; APACT Investigators.

J Clin Oncol. 2022 Dec 15:JCO2201134. doi: 10.1200/JCO.22.01134. Online ahead of print.

PMID: 36521097

 

Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates via the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines.

Zhao R, Hong Z, Wang B, Kempson J, Cornelius L, Li J, Li YX, Mathur A.

Org Biomol Chem. 2022 Dec 14;20(48):9746-9752. doi: 10.1039/d2ob02006h.

PMID: 36444969

 

Overcoming Photochemical Limitations in Metallaphotoredox Catalysis: Red-Light-Driven C-N Cross-Coupling.

Goldschmid SL, Soon Tay NE, Joe CL, Lainhart BC, Sherwood TC, Simmons EM, Sezen-Edmonds M, Rovis T.

J Am Chem Soc. 2022 Dec 14;144(49):22409-22415. doi: 10.1021/jacs.2c09745. Epub 2022 Nov 23.

PMID: 36417474

Effectiveness of Nivolumab in Second-Line and Later in Patients with Advanced Non-Small Cell Lung Cancer in Real-Life Practice in France and Germany: Analysis of the ESME-AMLC and CRISP Cohorts.

Chouaid C, Thomas M, Debieuvre D, Durand-Zaleski I, Zacharias S, Bosquet L, Groth A, Fleitz A, Calleja A, Patel S, Lacoin L, Daumont MJ, Penrod JR, Carroll R, Waldenberger D, Cotté FE, Audigier-Valette C, Griesinger F.

Cancers (Basel). 2022 Dec 13;14(24):6148. doi: 10.3390/cancers14246148.

PMID: 36551632

 

Nivolumab Plus Cabozantinib With or Without Ipilimumab for Advanced Hepatocellular Carcinoma: Results From Cohort 6 of the CheckMate 040 Trial.

Yau T, Zagonel V, Santoro A, Acosta-Rivera M, Choo SP, Matilla A, He AR, Cubillo Gracian A, El-Khoueiry AB, Sangro B, Eldawy TE, Bruix J, Frassineti GL, Vaccaro GM, Tschaika M, Scheffold C, Koopmans P, Neely J, Piscaglia F.

J Clin Oncol. 2022 Dec 13:JCO2200972. doi: 10.1200/JCO.22.00972. Online ahead of print.

PMID: 36512738

 

Indirect treatment comparison of oral versus injectable azacitidine as maintenance therapy for acute myeloid leukemia.

Tabah A, Huggar D, Wang ST, Johnson SJ, Copher RM, O'Connell T, McBride A, LeBlanc TW.

Future Oncol. 2022 Dec 12. doi: 10.2217/fon-2022-0820. Online ahead of print.

PMID: 36507931

 

Collaborative Assessment of Molecular Geometries and Energies from the Open Force Field.

D'Amore L, Hahn DF, Dotson DL, Horton JT, Anwar J, Craig I, Fox T, Gobbi A, Lakkaraju SK, Lucas X, Meier K, Mobley DL, Narayanan A, Schindler CEM, Swope WC, In 't Veld PJ, Wagner J, Xue B, Tresadern G.

J Chem Inf Model. 2022 Dec 12;62(23):6094-6104. doi: 10.1021/acs.jcim.2c01185. Epub 2022 Nov 26.

PMID: 36433835

 

Strategies for Managing Solid Form Transformation Risk in Drug Product.

Kestur U, Patel A, Badawy S, Mathias N, Zhang L.

J Pharm Sci. 2022 Dec 10:S0022-3549(22)00565-2. doi: 10.1016/j.xphs.2022.12.002. Online ahead of print.

PMID: 36513146

 

A Comparison of Alternative Network Meta-Analysis Methods in the Presence of Nonproportional Hazards: A Case Study in First-Line Advanced or Metastatic Renal Cell Carcinoma.

Cope S, Chan K, Campbell H, Chen J, Borrill J, May JR, Malcolm W, Branchoux S, Kupas K, Jansen JP.

Value Health. 2022 Dec 9:S1098-3015(22)04749-0. doi: 10.1016/j.jval.2022.11.017. Online ahead of print.

PMID: 36503035

 

Role of the Clinical Data Managers during the COVID-19 Pandemic: An Overview.

Sajja R.

Rev Recent Clin Trials. 2022 Dec 8. doi: 10.2174/1574887118666221208123724. Online ahead of print.

PMID: 36503462

 

Pulmonary Thromboembolism Developed During Hospitalization: A Nationwide Retrospective Observational Study Using Claims Data.

Imura M, Yamamoto T, Hiasa KI.

Cardiol Ther. 2022 Dec 8:1-15. doi: 10.1007/s40119-022-00290-6. Online ahead of print.

PMID: 36482141

 

Therapeutic Protein Drug Interactions: A White Paper From the International Consortium for Innovation and Quality in Pharmaceutical Development.

Coutant DE, Boulton DW, Dahal UP, Deslandes A, Grimaldi C, Pereira JNS, Säll C, Sarvaiya H, Schiller H, Tai G, Umehara K, Yuan Y, Dallas S.

Clin Pharmacol Ther. 2022 Dec 8. doi: 10.1002/cpt.2814. Online ahead of print.

PMID: 36477720

 

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.

Hartz RA, Xu L, Sit SY, Chen J, Venables BL, Lin Z, Zhang S, Li Z, Parker D, Simmons TS, Jenkins S, Hanumegowda UM, Dicker I, Krystal M, Meanwell NA, Regueiro-Ren A.

J Med Chem. 2022 Dec 8;65(23):15935-15966. doi: 10.1021/acs.jmedchem.2c01618. Epub 2022 Nov 28.

PMID: 36441509

 

Biomarkers predictive of response to pembrolizumab in head and neck cancer.

Pfister DG, Haddad RI, Worden FP, Weiss J, Mehra R, Chow LQM, Liu SV, Kang H, Saba NF, Wirth LJ, Sukari A, Massarelli E, Ayers M, Albright A, Webber AL, Mogg R, Lunceford J, Huang L, Cristescu R, Cheng J, Seiwert TY, Bauml JM.

Cancer Med. 2022 Dec 7. doi: 10.1002/cam4.5434. Online ahead of print.

PMID: 36479637

 

Capacitance spectroscopy enables real-time monitoring of early cell death in mammalian cell culture.

Wu S, Ketcham SA, Corredor CC, Both D, Drennen JK, Anderson CA.

Biotechnol J. 2022 Dec 7:e2200231. doi: 10.1002/biot.202200231. Online ahead of print.

PMID: 36479620

 

Targeting RARA Overexpression with Tamibarotene, a Potent and Selective RARα Agonist, is a Novel Approach in AML.

de Botton S, Cluzeau T, Vigil CE, Cook R, Rousselot P, Rizzieri DA, Liesveld JL, Fenaux P, Braun T, Banos A, Jurcic JG, Sekeres MA, Savona MR, Roboz GJ, Bixby D, Madigan K, Volkert A, Stephens K, Kang-Fortner Q, Baker K, Paul S, McKeown MR, Carulli JP, Eaton ML, Hodgson G, Fiore C, Kelly M, Roth DA, Stein EM.

Blood Adv. 2022 Dec 7:bloodadvances.2022008806. doi: 10.1182/bloodadvances.2022008806. Online ahead of print.

PMID: 36477975

 

Nivolumab Plus Ipilimumab Versus EXTREME Regimen as First-Line Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: The Final Results of CheckMate 651.

Haddad RI, Harrington K, Tahara M, Ferris RL, Gillison M, Fayette J, Daste A, Koralewski P, Zurawski B, Taberna M, Saba NF, Mak M, Kawecki A, Girotto G, Alvarez Avitia MA, Even C, Toledo JGR, Guminski A, Müller-Richter U, Kiyota N, Roberts M, Khan TA, Miller-Moslin K, Wei L, Argiris A.

J Clin Oncol. 2022 Dec 6:JCO2200332. doi: 10.1200/JCO.22.00332. Online ahead of print.

PMID: 36473143

 

Addendum: Real-world survival analysis by tumor mutational burden in non-small cell lung cancer: a multisite U.S. study.

Willis C, Bauer H, Au TH, Menon J, Unni S, Tran D, Rivers Z, Akerley W, Schabath MB, Badin F, Sekhon A, Patel M, Xia B, Gustafson B, Villano JL, Thomas JM, Lubinga SJ, Cantrell MA, Brixner D, Stenehjem D.

Oncotarget. 2022 Dec 6;13:1306. doi: 10.18632/oncotarget.28318.

PMID: 36473137

 

Apixaban for Patients With Atrial Fibrillation on Hemodialysis: A Multicenter Randomized Controlled Trial.

Pokorney SD, Chertow GM, Al-Khalidi HR, Gallup D, Dignacco P, Mussina K, Bansal N, Gadegbeku CA, Garcia DA, Garonzik S, Lopes RD, Mahaffey KW, Matsuda K, Middleton JP, Rymer JA, Sands GH, Thadhani R, Thomas KL, Washam JB, Winkelmayer WC, Granger CB; RENAL-AF Investigators.

Circulation. 2022 Dec 6;146(23):1735-1745. doi: 10.1161/CIRCULATIONAHA.121.054990. Epub 2022 Nov 6.

PMID: 36335914

 

Quantitative spatial evaluation of tumor-immune interactions in the immunotherapy setting of metastatic melanoma lymph nodes.

Maus RLG, Leontovich AA, Moore RM, Fogarty Z, Guo R, Davidson TM, Tekin B, Atherton C, Schimke JM, Dicke BA, Chen BJ, Markovic SN.

Front Immunol. 2022 Dec 5;13:1024039. doi: 10.3389/fimmu.2022.1024039. eCollection 2022.PMID: 36544759

 

Long-term safety and erythroid response with luspatercept treatment in patients with β-thalassemia.

Piga A, Longo F, Gamberini MR, Voskaridou E, Ricchi P, Caruso V, Pietrangelo A, Zhang X, Shetty JK, Attie KM, Tartaglione I.

Ther Adv Hematol. 2022 Dec 5;13:20406207221134404. doi: 10.1177/20406207221134404. eCollection 2022.

PMID: 36505885

 

End-to-End Approach to Surfactant Selection, Risk Mitigation, and Control Strategies for Protein-Based Therapeutics.

Morales AM, Sreedhara A, Buecheler J, Brosig S, Chou D, Christian T, Das T, de Jong I, Fast J, Jagannathan B, Moussa EM, Nejadnik MR, Prajapati I, Radwick A, Rahman Y, Singh S.

AAPS J. 2022 Dec 5;25(1):6. doi: 10.1208/s12248-022-00773-3.

PMID: 36471030 

Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model.

Zhu H, Lan C, Zhao D, Wang N, Du D, Luo H, Lu H, Peng Z, Wang Y, Qiao Z, Huang Y, Sun B.

NPJ Sci Food. 2022 Dec 5;6(1):55. doi: 10.1038/s41538-022-00170-2.

PMID: 36470888

 

Immunopurification Reagents and Their Application in Biologics and Biomarker Quantitation Using LC-MS/MS in Drug Discovery.

Gautam SS, Singh SP.

J Chromatogr Sci. 2022 Dec 5:bmac096. doi: 10.1093/chromsci/bmac096. Online ahead of print.

PMID: 36469494

 

Cardiac myosin filaments are directly regulated by calcium.

Ma W, Nag S, Gong H, Qi L, Irving TC.

J Gen Physiol. 2022 Dec 5;154(12):e202213213. doi: 10.1085/jgp.202213213. Epub 2022 Nov 1.

PMID: 36327149

 

Continuous feeding and blending demonstration with co-processed drug substance.

Erdemir D, Gawel J, Yohannes B, Yates P, Tang D, Ha K, Breza B, DiMaso E, Abebe A, Zombek J.

J Pharm Sci. 2022 Dec 1:S0022-3549(22)00535-4. doi: 10.1016/j.xphs.2022.11.023. Online ahead of print.

PMID: 36462708

 

iCoreDrop: A robust immune monitoring spectral cytometry assay with six open channels for biomarker flexibility.

Jensen HA, Kim J.

Cytometry A. 2022 Dec 1. doi: 10.1002/cyto.a.24708. Online ahead of print.

PMID: 36458334

 

Management of Concomitant Inflammatory Bowel Disease or Uveitis in Patients With Psoriatic Arthritis: An Updated Review Informing the 2021 GRAPPA Treatment Recommendations.

Jadon DR, Corp N, van der Windt DA, Coates LC, Soriano ER, Kavanaugh A, Raine T, Rieder F, Siebert S, Zummer M, Schwartzman S, Rosenbaum JT, Michelsen B, Laxminarayan R, Wu D, Gupta L, Ng B, Jethwa H, De Windt N, Gudu T, Hutton J, O'Sullivan D, Luchetti MM, Stoll M, Singh JA, Peluso R, Rademacher J, Husni ME.

J Rheumatol. 2022 Dec 1:jrheum.220317. doi: 10.3899/jrheum.220317. Online ahead of print.

PMID: 36455946

 

One-Third of European Patients with Axial Spondyloarthritis Reach Pain Remission With Routine Care Tumor Necrosis Factor Inhibitor Treatment.

Ørnbjerg LM, Rugbjerg K, Georgiadis S, Rasmussen SH, Lindström U, Pavelka K, Yilmaz N, Favalli EG, Nissen MJ, Michelsen B, Vieira-Sousa E, Jones GT, Ionescu R, Relas H, Sanchez-Piedra C, Tomšič M, Geirsson AJ, van der Horst-Bruinsma I, Askling J, Loft AG, Nekvindova L, Direskeneli H, Iannone F, Ciurea A, Fagerli KM, Santos MJ, Macfarlane GJ, Codreanu C, Eklund K, Pombo-Suarez M, Rotar Z, Gudbjornsson B, Rusman T, Østergaard M, Hetland ML.

J Rheumatol. 2022 Dec 1:jrheum.220459. doi: 10.3899/jrheum.220459. Online ahead of print.

PMID: 36455943

 

Trotabresib, an oral potent bromodomain and extraterminal inhibitor, in patients with high-grade gliomas: a phase I, "windowofopportunity" study.

Moreno V, Sepulveda JM, Reardon DA, Pérez-Núñez Á, González León P, Hanna B, Filvaroff E, Aronchik I, Chang H, Amoroso B, Zuraek M, Sanchez-Perez T, Mendez C, Stephens D, Nikolova Z, Vogelbaum MA.

Neuro Oncol. 2022 Dec 1:noac263. doi: 10.1093/neuonc/noac263. Online ahead of print.

PMID: 36455228

 

A multi-omic single cell sequencing approach to develop a CD8 T cell specific gene signature for anti-PD1 response in solid tumors.

Kumar N, Papillon-Cavanagh S, Tang H, Wang S, Stromko C, Ho CP, Soni-Sheth S, Vasquez-Grinnell S, Broz ML, Tenney DJ, Wichroski MJ, Walsh AM, Hu Y, Benci JL.

Int J Cancer. 2022 Dec 1;151(11):2043-2054. doi: 10.1002/ijc.34218. Epub 2022 Aug 6.

PMID: 35932450

 

Baseline serum levels of cross-linked carboxy-terminal telopeptide of type I collagen predict abatacept treatment response in methotrexate-naive, anticitrullinated protein antibody-positive patients with early rheumatoid arthritis.

Wu C, Hu Y, Schafer P, Connolly SE, Wong R, Nielsen SH, Bay-Jensen AC, Emery P, Tanaka Y, Bykerk VP, Bingham CO, Huizinga TW, Fleischmann R, Liu J.

RMD Open. 2022 Dec;8(2):e002683. doi: 10.1136/rmdopen-2022-002683.

PMID: 36585217

 

Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma.

Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM.

J Immunother Cancer. 2022 Dec;10(12):e005445. doi: 10.1136/jitc-2022-005445.

PMID: 36549781

 

Ovarian cancer mutational processes drive site-specific immune evasion.

Vázquez-García I, Uhlitz F, Ceglia N, Lim JLP, Wu M, Mohibullah N, Niyazov J, Ruiz AEB, Boehm KM, Bojilova V, Fong CJ, Funnell T, Grewal D, Havasov E, Leung S, Pasha A, Patel DM, Pourmaleki M, Rusk N, Shi H, Vanguri R, Williams MJ, Zhang AW, Broach V, Chi DS, Da Cruz Paula A, Gardner GJ, Kim SH, Lennon M, Long Roche K, Sonoda Y, Zivanovic O, Kundra R, Viale A, Derakhshan FN, Geneslaw L, Issa Bhaloo S, Maroldi A, Nunez R, Pareja F, Stylianou A, Vahdatinia M, Bykov Y, Grisham RN, Liu YL, Lakhman Y, Nikolovski I, Kelly D, Gao J, Schietinger A, Hollmann TJ, Bakhoum SF, Soslow RA, Ellenson LH, Abu-Rustum NR, Aghajanian C, Friedman CF, McPherson A, Weigelt B, Zamarin D, Shah SP.

Nature. 2022 Dec;612(7941):778-786. doi: 10.1038/s41586-022-05496-1. Epub 2022 Dec 14.

PMID: 36517593

 

Overview of Clinical Pharmacology Packages of New Drug Applications Approved for the Treatment of Rare Diseases.

Qosa H, Hassan HE, Younis IR.

J Clin Pharmacol. 2022 Dec;62 Suppl 2:S72-S78. doi: 10.1002/jcph.2167.

PMID: 36461747

 

Myosin Inhibition and Left Ventricular Diastolic Function in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy: Insights From the VALOR-HCM Study.

Cremer PC, Geske JB, Owens A, Jaber WA, Harb SC, Saberi S, Wang A, Sherrid M, Naidu SS, Schaff H, Smedira NG, Wang Q, Wolski K, Lampl KL, Sehnert AJ, Nissen SE, Desai MY.

Circ Cardiovasc Imaging. 2022 Dec;15(12):e014986. doi: 10.1161/CIRCIMAGING.122.014986. Epub 2022 Nov 6.

PMID: 36335645

 

Nivolumab plus ipilimumab plus cabozantinib triplet combination for patients with previously untreated advanced renal cell carcinoma: Results from a discontinued arm of the phase III CheckMate 9ER trial.

Apolo AB, Powles T, Escudier B, Burotto M, Zhang J, Simsek B, Scheffold C, Motzer RJ, Choueiri TK.

Eur J Cancer. 2022 Dec;177:63-71. doi: 10.1016/j.ejca.2022.09.020. Epub 2022 Oct 4.

PMID: 36327527

 

The Dog as a Second Species for Toxicology Testing Provides Value to Drug Development.

Bower N, Achanzar WE, Boulifard V, Brinck PR, Kittel B, Vahle JL.

Int J Toxicol. 2022 Dec;41(6):431-441. doi: 10.1177/10915818221125670. Epub 2022 Sep 15.

PMID: 36112859

 

Rejoinder: Improving the performance of Bayesian logistic regression model with overdose control in oncology dose-finding studies.

Zhang H, Chiang AY, Wang J.

Stat Med. 2022 Nov 30;41(27):5497-5500. doi: 10.1002/sim.9561.

PMID: 36394103

 

SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response.

Ibáñez-Molero S, van Vliet A, Pozniak J, Hummelink K, Terry AM, Monkhorst K, Sanders J, Hofland I, Landeloos E, Van Herck Y, Bechter O, Kuilman T, Zhong W, Marine JC, Wessels L, Peeper DS.

Oncoimmunology. 2022 Nov 29;11(1):2139074. doi: 10.1080/2162402X.2022.2139074. eCollection 2022.

PMID: 36465485

 

Evaluation of Novel Urinary Biomarkers in Beagle Dogs With Amphotericin B-Induced Kidney Injury.

Adedeji AO, Sonee M, Chen Y, Lynch K, Peron K, King N, McDuffie JE, Vinken P.

Int J Toxicol. 2022 Nov 25:10915818221142542. doi: 10.1177/10915818221142542. Online ahead of print.

PMID: 36427267

 

Effect of beta-blocker therapy on the response to mavacamten in patients with symptomatic obstructive hypertrophic cardiomyopathy.

Wheeler MT, Jacoby D, Elliott PM, Saberi S, Hegde SM, Lakdawala NK, Myers J, Sehnert AJ, Edelberg JM, Li W, Olivotto I.

Eur J Heart Fail. 2022 Nov 20. doi: 10.1002/ejhf.2737. Online ahead of print.

PMID: 36404399

 

An open label, safety study of Asian patients with advanced non-small-cell lung cancer receiving second-line nivolumab monotherapy (CheckMate 870).

Lu S, Cheng Y, Zhou J, Wang M, Zhao J, Wang B, Chen G, Feng J, Ma Z, Wu L, Wang C, Ma K, Zhang S, Liang J, Song Y, Wang J, Wu YL, Li A, Huang Y, Chang J.

Ther Adv Med Oncol. 2022 Nov 19;14:17588359221138380. doi: 10.1177/17588359221138380. eCollection 2022.

PMID: 36425873

 

Ceramic hydroxyapatite chromatography plays a critical role in bispecific antibody purification process for impurity removal.

Waller JA, Zheng J, Dyer R, Slaney T, Wu W, Tao L, Ghose S.

Antib Ther. 2022 Nov 19;6(1):30-37. doi: 10.1093/abt/tbac030. eCollection 2023 Jan.

PMID: 36683764

 

First-line nivolumab plus ipilimumab or chemotherapy versus chemotherapy alone in advanced esophageal squamous cell carcinoma: a Japanese subgroup analysis of open-label, phase 3 trial (CheckMate 648/ONO-4538-50).

Kato K, Doki Y, Ogata T, Motoyama S, Kawakami H, Ueno M, Kojima T, Shirakawa Y, Okada M, Ishihara R, Kubota Y, Amaya-Chanaga C, Chen T, Matsumura Y, Kitagawa Y.

Esophagus. 2022 Nov 19. doi: 10.1007/s10388-022-00970-1. Online ahead of print.

PMID: 36401133

 

The challenges inherent with anchor-based approaches to the interpretation of important change in clinical outcome assessments.

Wyrwich KW, Norman GR.

Qual Life Res. 2022 Nov 18. doi: 10.1007/s11136-022-03297-7. Online ahead of print.

PMID: 36396874

 

Risk and response adapted therapy following autologous stem cell transplant in patients with newly diagnosed multiple myeloma (RADAR (UK-MRA Myeloma XV Trial): study protocol for a phase II/III randomised controlled trial.

Royle KL, Coulson AB, Ramasamy K, Cairns DA, Hockaday A, Quezada S, Drayson M, Kaiser M, Owen R, Auner HW, Cook G, Meads D, Olivier C, Barnard L, Lambkin R, Paterson A, Dawkins B, Chapman M, Pratt G, Popat R, Jackson G, Bygrave C, Sive J, de Tute R, Chantry A, Parrish C, Cook M, Asher S, Yong K.

BMJ Open. 2022 Nov 17;12(11):e063037. doi: 10.1136/bmjopen-2022-063037.

PMID: 36396306

 

Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study.

de la Rubia J, González B, Cruz-Jentoft AJ, Iglesias L, Jarque I, Persona EP, Lluch R, Marrero C, Zudaire M, Gironella M, Hernández-Rivas JÁ, Arnan M, Olivier C, Encinas C, Soler JA, Payer ÁR, Casado A, Fernández P, Vilanova D, Bonanad S.

J Geriatr Oncol. 2022 Nov 17:S1879-4068(22)00520-3. doi: 10.1016/j.jgo.2022.10.016. Online ahead of print.

PMID: 36404260

 

Cost-consequence of abatacept as first-line therapy in Japanese rheumatoid arthritis patients using IORRA real-world data.

Tanaka E, Inoue E, Shoji A, Nilsson J, Papagiannopoulos C, Dhanda D, Yoshizawa Y, Abe M, Saka K, Sugano E, Sugitani N, Ochiai M, Yamaguchi R, Ikari K, Yamanaka H, Harigai M.

PLoS One. 2022 Nov 16;17(11):e0277566. doi: 10.1371/journal.pone.0277566. eCollection 2022.

PMID: 36383610

 

Assessment of spatial transcriptomics for oncology discovery.

Lyubetskaya A, Rabe B, Fisher A, Lewin A, Neuhaus I, Brett C, Brett T, Pereira E, Golhar R, Kebede S, Font-Tello A, Mosure K, Van Wittenberghe N, Mavrakis KJ, MacIsaac K, Chen BJ, Drokhlyansky E.

Cell Rep Methods. 2022 Nov 15;2(11):100340. doi: 10.1016/j.crmeth.2022.100340. eCollection 2022 Nov 21.

PMID: 36452860

 

Noninvasive Moisture Detection in Lyophilized Drug Product Using NIR Spectrometer and Headspace Moisture Analyzer.

Pu YE, Li Y, Xiang D.

J Pharm Sci. 2022 Nov 15:S0022-3549(22)00524-X. doi: 10.1016/j.xphs.2022.11.009. Online ahead of print.

PMID: 36395899

 

Etanercept Withdrawal and Retreatment in Nonradiographic Axial Spondyloarthritis: Results of RE-EMBARK, an Open-Label Phase IV Trial.

Van den Bosch F, Wei JC, Nash P, Blanco FJ, Graham D, Zang C, Arthur E, Borlenghi C, Tsekouras V, Vlahos B, Deodhar A.

J Rheumatol. 2022 Nov 15:jrheum.220353. doi: 10.3899/jrheum.220353. Online ahead of print.

PMID: 36379575

 

Frailty in Inflammatory Arthritis: A Fragile Construct.

van Onna M, Boonen A.

J Rheumatol. 2022 Nov 15:jrheum.220954. doi: 10.3899/jrheum.220954. Online ahead of print.

PMID: 36379574

 

Assessing fatigue and sleep in chronic diseases using physiological signals from wearables: A pilot study.

Antikainen E, Njoum H, Kudelka J, Branco D, Rehman RZU, Macrae V, Davies K, Hildesheim H, Emmert K, Reilmann R, Janneke van der Woude C, Maetzler W, Ng WF, O'Donnell P, Van Gassen G, Baribaud F, Pandis I, Manyakov NV, van Gils M, Ahmaniemi T, Chatterjee M.

Front Physiol. 2022 Nov 14; 13:968185. doi: 10.3389/fphys.2022.968185. eCollection 2022.

PMID: 36452041

 

Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop.

Mills CE, Subramanian K, Hafner M, Niepel M, Gerosa L, Chung M, Victor C, Gaudio B, Yapp C, Nirmal AJ, Clark N, Sorger PK.

Nat Commun. 2022 Nov 14;13(1):6918. doi: 10.1038/s41467-022-34536-7.

PMID: 36376301

 

Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution.

Sodir NM, Pellegrinet L, Kortlever RM, Campos T, Kwon YW, Kim S, Garcia D, Perfetto A, Anastasiou P, Swigart LB, Arends MJ, Littlewood TD, Evan GI.

Nat Commun. 2022 Nov 9;13(1):6782. doi: 10.1038/s41467-022-34079-x.

PMID: 36351945

 

Facile Amide Bond Formation with TCFH-NMI in an Organic Laboratory Course.

M Baldwin OW, Conrad-Marut LH, Beutner GL, Vosburg DA.

J Chem Educ. 2022 Nov 8;99(11):3747-3751. doi: 10.1021/acs.jchemed.2c00760. Epub 2022 Oct 3.

PMID: 36398314

 

An epitope-enriched immunogen expands responses to a conserved viral site.

Caradonna TM, Ronsard L, Yousif AS, Windsor IW, Hecht R, Bracamonte-Moreno T, Roffler AA, Maron MJ, Maurer DP, Feldman J, Marchiori E, Barnes RM, Rohrer D, Lonberg N, Oguin TH 3rd, Sempowski GD, Kepler TB, Kuraoka M, Lingwood D, Schmidt AG.

Cell Rep. 2022 Nov 8;41(6):111628. doi: 10.1016/j.celrep.2022.111628.

PMID: 36351401

 

Dose-Blinded Myosin Inhibition in Patients with Obstructive HCM Referred for Septal Reduction Therapy: Outcomes Through 32-Weeks.

Desai MY, Owens AT, Geske JB, Wolski K, Saberi S, Wang A, Sherrid MV, Cremer PC, Naidu SS, Smedira N, Schaff HV, McErlean E, Sewell C, Balasubramanyam A, Lampl K, Sehnert AJ, Nissen SE.

Circulation. 2022 Nov 6. doi: 10.1161/CIRCULATIONAHA.122.062534. Online ahead of print.

PMID: 36335531

 

Molecular glue CELMoD compounds are regulators of cereblon conformation.

Watson ER, Novick S, Matyskiela ME, Chamberlain PP, H de la Peña A, Zhu J, Tran E, Griffin PR, Wertz IE, Lander GC.

Science. 2022 Nov 4;378(6619):549-553. doi: 10.1126/science.add7574. Epub 2022 Nov 3.

PMID: 36378961

 

Practice patterns and outcomes for triple-class exposed patients with relapsed/refractory multiple myeloma in Japan.

Iida S, Nakakoji M, Spanopoulos D, Okazuka K, Parulekar V, Ishida T.

Future Oncol. 2022 Nov 4. doi: 10.2217/fon-2022-0846. Online ahead of print.

PMID: 36331578

 

Quantum Cascade Laser Based Infrared Spectroscopy: A New Paradigm for Protein Secondary Structure Measurement.

Jin C, Patel A, Peters J, Hodawadekar S, Kalyanaraman R.

Pharm Res. 2022 Nov 3. doi: 10.1007/s11095-022-03422-8. Online ahead of print.

PMID: 36329374

 

On the use of extreme value tail modeling for generalized pairwise comparisons with censored outcomes.

De Backer M, Legrand C, Péron J, Lambert A, Buyse M.

Pharm Stat. 2022 Nov 2. doi: 10.1002/pst.2271. Online ahead of print.

PMID: 36321470

 

A Multi-Objective Active Learning Platform and Web App for Reaction Optimization.

Torres JAG, Lau SH, Anchuri P, Stevens JM, Tabora JE, Li J, Borovika A, Adams RP, Doyle AG.

J Am Chem Soc. 2022 Nov 2;144(43):19999-20007. doi: 10.1021/jacs.2c08592. Epub 2022 Oct 19.

PMID: 36260788

 

Quantification of Utilization Management Barriers for Patients Initiating Therapy to Lower Lipid Levels.

O'Neil A, Calderbank S, Brown J, Vandigo J, Yin P, Bratti K, Howell S.

JAMA Netw Open. 2022 Nov 1;5(11): e2240513. doi: 10.1001/jamanetworkopen.2022.40513.

PMID: 36346635

 

MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.

Cheng D, Zinker BA, Luo Y, Shipkova P, De Oliveira CH, Krishna G, Brown EA, Boehm SL, Tirucherai GS, Gu H, Ma Z, Chu CH, Onorato JM, Kopcho LM, Ammar R, Smith J, Devasthale P, Lawrence RM, Stryker SA, Dierks EA, Azzara AV, Carayannopoulos L, Charles ED, Lentz KA, Gordon DA.

Cell Metab. 2022 Nov 1;34(11):1732-1748.e5. doi: 10.1016/j.cmet.2022.10.007.

PMID: 36323235

 

Management of Nail Disease in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations.

Laheru D, Antony A, Carneiro S, Di Lernia V, Garg A, Love TJ, Del Rocio Macias Garcia K, Mendonça JA, Mukherjee S, Olteanu R, Perez-Chada L, Rosen CF, Tannenbaum R, Yazbek MA.

J Rheumatol. 2022 Nov 1: jrheum.220313. doi: 10.3899/jrheum.220313. Online ahead of print.

PMID: 36319021

 

Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations.

Campanholo CB, Maharaj AB, Corp N, Bell S, Costa L, de Vlam K, Gullick NJ, Khraishi M, Kishimoto M, Palmou-Fontana N, Reddy S, Scarpa R, Vega L, Duarte GV, Zisman D, van der Windt DA, Duruoz MT, Ogdie A.

J Rheumatol. 2022 Nov 1: jrheum.220310. doi: 10.3899/jrheum.220310. Online ahead of print.

PMID: 36319003

 

Pseudoprolines as stereoelectronically tunable proline isosteres.

Kashif Khan R, Meanwell NA, Hager HH.

Bioorg Med Chem Lett. 2022 Nov 1; 75:128983. doi: 10.1016/j.bmcl.2022.128983. Epub 2022 Sep 9.

PMID: 36096342

 

The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer.

Padmakar Darne C, Velaparthi U, Saulnier M, Frennesson D, Liu P, Huang A, Tokarski J, Fura A, Spires T, Newitt J, Spires VM, Obermeier MT, Elzinga PA, Gottardis MM, Jayaraman L, Vite GD, Balog A.

Bioorg Med Chem Lett. 2022 Nov 1; 75:128951. doi: 10.1016/j.bmcl.2022.128951. Epub 2022 Aug 27.

PMID: 36031020

 

Proceedings From the ASCO/College of American Pathologists Immune Checkpoint Inhibitor Predictive Biomarker Summit.

Hayes DF, Herbst RS, Myles JL, Topalian SL, Yohe SL, Aronson N, Bellizzi AM, Basu Roy U, Bradshaw G, Edwards RH, El-Gabry EA, Elvin J, Gajewski TF, McShane LM, Oberley M, Philip R, Rimm DL, Rosenbaum JN, Rubin EH, Schlager L, Sherwood SW, Stewart M, Taube JM, Thurin M, Vasalos P, Laser J.

JCO Precis Oncol. 2022 Nov;6: e2200454. doi: 10.1200/PO.22.00454.

PMID: 36446042

 

FRACTION-RCC: nivolumab plus ipilimumab for advanced renal cell carcinoma after progression on immuno-oncology therapy.

Choueiri TK, Kluger H, George S, Tykodi SS, Kuzel TM, Perets R, Nair S, Procopio G, Carducci MA, Castonguay V, Folefac E, Lee CH, Hotte SJ, Miller WH Jr, Saggi SS, Lee CW, Desilva H, Bhagavatheeswaran P, Motzer RJ, Escudier B.

J Immunother Cancer. 2022 Nov;10(11): e005780. doi: 10.1136/jitc-2022-005780.

PMID: 36328377

 

MAPK activated kinase 2 inhibition shifts the chemokine signature in arthritis synovial fluid mononuclear cells from CXCR3 to CXCR2.

Kragstrup TW, Sørensen AS, Brüner M, Lomholt S, Nielsen MA, Schafer P, Deleuran B.

Int Immunopharmacol. 2022 Nov; 112:109267. doi: 10.1016/j.intimp.2022.109267. Epub 2022 Sep 28.

PMID: 36179420

 

Correction: Thrombotic and bleeding events, mortality, and anticoagulant use among 546,656 hospitalized patients with COVID‑19 in the United States: a retrospective cohort study.

Deitelzweig S, Luo X, Nguyen JL, Malhotra D, Emir B, Russ C, Li X, Lee TC, Ferri M, Wiederkehr D, Reimbaeva M, Barnes GD, Piazza G.

J Thromb Thrombolysis. 2022 Nov;54(4):696. doi: 10.1007/s11239-022-02708-3. Epub 2022 Sep 19.

PMID: 36121539

 

Real-world clinical outcomes with enasidenib in relapsed or refractory acute myeloid leukemia.

Klink AJ, Gajra A, Knoth RL, Marshall L, Hou Y, McBride A, Copher R.

Leuk Res. 2022 Nov; 122:106946. doi: 10.1016/j.leukres.2022.106946. Epub 2022 Sep 5.

PMID: 36108427

 

Factors Affecting the Clinical Course of Follicular Lymphoma: A Multistate Survival Analysis Using Individual Patient Data from Eight Multicenter Randomized Clinical Trials.

Dixon JG, Çağlayan Ç, Chihara D, Nielsen T, Dimier N, Zheng J, Wall AK, Salles G, Morschhauser F, Marcus R, Herold M, Kimby E, Blum KA, Ghielmini M, Shi Q, Flowers CR.

Clin Lymphoma Myeloma Leuk. 2022 Nov;22(11): e1009-e1018. doi: 10.1016/j.clml.2022.07.015. Epub 2022 Aug 3.

PMID: 36045021

 

PD-L1 protein expression in relation to recurrence score values in early-stage ER + breast cancer.

Rozenblit M, Blenman K, Harigopal M, Reisenbichler E, Singh K, Qing T, Ibrahim E, Ramkissoon S, Asmelash S, Lin HK, Roberts M, Ross J, Huang RSP, Pusztai L.

Breast Cancer Res Treat. 2022 Nov;196(1):221-227. doi: 10.1007/s10549-022-06712-2. Epub 2022 Aug 26.

PMID: 36028784

 

Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines.

Trejo-Martin A, Bercu JP, Thresher A, Tennant RE, Thomas RF, Cross K, Czich A, Waese K, Nicolette JJ, Murray J, Sonders P, Kondratiuk A, Cheung JR, Thomas D, Lynch A, Harvey J, Glowienke S, Custer L, Escobar PA.

Regul Toxicol Pharmacol. 2022 Nov; 135:105247. doi: 10.1016/j.yrtph.2022.105247. Epub 2022 Aug 23.

PMID: 35998738

 

The Role of Titanium Dioxide (E171) and the Requirements for Replacement Materials in Oral Solid Dosage Forms: An IQ Consortium Working Group Review.

Blundell R, Butterworth P, Charlier A, Daurio D, Degenhardt M, Harris D, Hancock B, Johnston M, Kasina R, Kaye J, Kelly R, Lienbacher P, Meehan L, Melnick J, Ojakovo P, Schoell J, Schimmelle B, Tobyn M, Wagner-Hattler L, Wakeman J, Wiedey R.

J Pharm Sci. 2022 Nov;111(11):2943-2954. doi: 10.1016/j.xphs.2022.08.011. Epub 2022 Aug 13.

PMID: 35973604

 

Treatment patterns, healthcare resource utilization, and costs in patients with moderate-to-severe psoriasis treated with systemic therapy in Japan: A retrospective claims database study.

Tada Y, Kim H, Spanopoulos D, Habiro K, Tsuritani K, Yamada Y, Mandal A, Zhong Y, Hikichi Y.

J Dermatol. 2022 Nov;49(11):1106-1117. doi: 10.1111/1346-8138.16543. Epub 2022 Aug 10.

PMID: 35946343

 

Developability Assessments of Monoclonal Antibody Candidates to Minimize Aggregation During Large-Scale Ultrafiltration and Diafiltration (UF-DF) Processing.

Whitaker N, Pace SE, Merritt K, Tadros M, Khossravi M, Deshmukh S, Cheng Y, Joshi SB, Volkin DB, Dhar P.

J Pharm Sci. 2022 Nov;111(11):2998-3008. doi: 10.1016/j.xphs.2022.08.001. Epub 2022 Aug 5.

PMID: 35940242

 

Trotabresib (CC-90010) in combination with adjuvant temozolomide or concomitant temozolomide plus radiotherapy in patients with newly diagnosed glioblastoma.

Vieito M, Simonelli M, de Vos F, Moreno V, Geurts M, Lorenzi E, Macchini M, van den Bent MJ, Del Conte G, de Jonge M, Martín-Soberón MC, Amoroso B, Sanchez-Perez T, Zuraek M, Hanna B, Aronchik I, Filvaroff E, Chang H, Mendez C, Arias Parro M, Wei X, Nikolova Z, Sepulveda JM.

Neurooncol Adv. 2022 Oct 28;4(1):vdac146. doi: 10.1093/noajnl/vdac146. eCollection 2022 Jan-Dec.

PMID: 36382109

 

Tracking the Progeny of Virus-specific T-cell Products in Patients Post-Transplant using TCR-Sequencing.

Huisman W, Roex MCJ, Hageman L, Koster EAS, Veld SAJ, Hoogstraten C, van Balen P, van Egmond HME, Van Bergen CAM, Einsele H, Germeroth L, Amsen D, Falkenburg JHF, Jedema I.

Blood Adv. 2022 Sep 19:bloodadvances.2022007270. doi: 10.1182/bloodadvances.2022007270. Online ahead of print.

PMID: 36121440

 

Preclinical target validation for non-addictive therapeutics development for pain.

Hargreaves R, Akinsanya K, Ajit SK, Dhruv NT, Driscoll J, Farina P, Gavva N, Gill M, Houghton A, Iyengar S, Jones C, Kavelaars A, Kaykas A, Koroshetz WJ, Laeng P, Laird JM, Lo DC, Luthman J, Munro G, Oshinsky ML, Sittampalam GS, Woller SA, Tamiz AP.

Expert Opin Ther Targets. 2022 Sep;26(9):811-822. doi: 10.1080/14728222.2022.2147063.

PMID: 36424892

 

BMS-986012, an Anti-Fucosyl-GM1 Monoclonal Antibody as Monotherapy or in Combination With Nivolumab in Relapsed/Refractory SCLC: Results From a First-in-Human Phase 1/2 Study.

Chu Q, Leighl NB, Surmont V, van Herpen C, Sibille A, Markman B, Clarke S, Juergens RA, Rivera MA, Andelkovic V, Rudin CM, Snow S, Kim DW, Sanatani M, Lin H, Sanghavi K, Tannenbaum-Dvir S, Basciano P, Lathers D, Urbanska K, Kollia G, He C, DiPiero A, Liu Y, Ready N.

JTO Clin Res Rep. 2022 Aug 27;3(11):100400. doi: 10.1016/j.jtocrr.2022.100400. eCollection 2022 Nov.

PMID: 36275912

 

Patient-Reported Outcomes Among Patients Ages Two to Seventeen Years With Polyarticular-Course Juvenile Idiopathic Arthritis Treated With Subcutaneous Abatacept: Two-Year Results From an International Phase III Study.

Ruperto N, Lovell DJ, Berman A, Ávila-Zapata F, Horneff G, Alessio M, Becker ML, Belot A, Burgos-Vargas R, Gamir ML, Goldenstein-Schainberg C, Scheibel IM, Terreri MT, Zemel L, Zhuo J, Askelson M, Wong R, Martini A, Brunner HI; Pediatric Rheumatology Collaborative Study Group and the Paediatric Rheumatology International Trials Organisation.

Arthritis Care Res (Hoboken). 2022 Aug 3. doi: 10.1002/acr.24989. Online ahead of print.

PMID: 36710243

 

Identification of undiagnosed atrial fibrillation using a machine learning risk-prediction algorithm and diagnostic testing (PULsE-AI) in primary care: a multi-centre randomized controlled trial in England.

Hill NR, Groves L, Dickerson C, Ochs A, Pang D, Lawton S, Hurst M, Pollock KG, Sugrue DM, Tsang C, Arden C, Wyn Davies D, Martin AC, Sandler B, Gordon J, Farooqui U, Clifton D, Mallen C, Rogers J, Camm AJ, Cohen AT.

Eur Heart J Digit Health. 2022 Mar 23;3(2):195-204. doi: 10.1093/ehjdh/ztac009. eCollection 2022 Jun.

PMID: 36713002 

 

Ru-Catalyzed Enantioselective Hydrogenation of 2-Pyridyl-Substituted Alkenes and Substrate-Mediated H/D Exchange.

Hao W, Joe CL, Ayers S, Darù A, Daley RA, Chen JS, Domanski M, Schmidt MA, Blackmond DG.

ACS Catal. 2022 Jan 21;12(2):1150-1160. doi: 10.1021/acscatal.1c05061. Epub 2022 Jan 4.

PMID: 36386561

 

Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper.

Ménochet K, Yu H, Wang B, Tibbitts J, Hsu CP, Kamath AV, Richter WF, Baumann A.

MAbs. 2022 Jan-Dec;14(1):2145997. doi: 10.1080/19420862.2022.2145997.

PMID: 36418217

 

Measurement and valuation of the attributes of innovation of healthcare technologies: a systematic review.

Syeed MS, Poudel N, Ngorsuraches S, Diaz J, Chaiyakunapruk N.

J Med Econ. 2022 Jan-Dec;25(1):1176-1184. doi: 10.1080/13696998.2022.2143170.

PMID: 36346390

 

Major variation in hepatocellular carcinoma treatment and outcomes in England: a retrospective cohort study.

Beecroft S, O'Connell M, Nassar A, Noon K, Pollock KG, Palmer D, Cross TJS.

Frontline Gastroenterol. 2022 May 9;14(1):19-24. doi: 10.1136/flgastro-2022-102142. eCollection 2023.

PMID: 36561791

 

Anti-drug Antibody Sample Testing and Reporting Harmonization.

Jani D, Marsden R, Gunsior M, Hay LS, Ward B, Cowan KJ, Azadeh M, Barker B, Cao L, Closson KR, Coble K, Dholakiya SL, Dusseault J, Hays A, Herl C, Hodsdon ME, Irvin SC, Kirshner S, Kolaitis G, Kulagina N, Kumar S, Lai CH, Lipari F, Liu S, Merdek KD, Moldovan IR, Mozaffari R, Pan L, Place C, Snoeck V, Manning MS, Stocker D, Tary-Lehmann M, Turner A, Vainshtein I, Verthelyi D, Williams WT, Yan H, Yan W, Yang L, Yang L, Zemo J, Zhong ZD.

AAPS J. 2022 Oct 28;24(6):113. doi: 10.1208/s12248-022-00762-6.

PMID: 36307592

 

Economic burden in US patients with newly diagnosed acute myeloid leukemia receiving intensive induction chemotherapy.

Huggar D, Knoth RL, Copher R, Cao Z, Lipkin C, McBride A, LeBlanc TW.

Future Oncol. 2022 Oct 28. doi: 10.2217/fon-2022-0706. Online ahead of print.

PMID: 36305495

 

Meta-Analysis of the Test-Retest Repeatability of [18F]-Fluorodeoxyglucose Standardized Uptake Values: Implications for Assessment of Tumor Response.

Shankar LK, Huang E, Litière S, Hoekstra OS, Schwartz L, Collette S, Boellaard R, Bogaerts J, Seymour L, de Vries EGE.

Clin Cancer Res. 2022 Oct 27:CCR-21-3143. doi: 10.1158/1078-0432.CCR-21-3143. Online ahead of print.

PMID: 36302172

 

Increased CaMKK2 expression is an adaptive response that maintains the fitness of tumor-infiltrating natural killer cells.

Juras PK, Racioppi L, Mukherjee D, Artham S, Gao X, D'Agostino LA, Chang CY, McDonnell DP.

Cancer Immunol Res. 2022 Oct 27:CIR-22-0391. doi: 10.1158/2326-6066.CIR-22-0391. Online ahead of print.

PMID: 36301267

 

Embryo-fetal Exposure and Developmental Outcome of Lenalidomide Following Oral Administration to Pregnant Cynomolgus Monkeys.

Hui JY, Fuchs A, Kumar G.

Reprod Toxicol. 2022 Oct 26:S0890-6238(22)00155-1. doi: 10.1016/j.reprotox.2022.10.005. Online ahead of print.

PMID: 36309155

 

Adjuvant nivolumab versus placebo following radical surgery for high-risk muscle-invasive urothelial carcinoma: a subgroup analysis of Japanese patients enrolled in the phase 3 CheckMate 274 trial.

Tomita Y, Kobayashi K, Kimura G, Oya M, Uemura H, Nishiyama H, Galsky MD, Nasroulah F, Collette S, Broughton E, Ünsal-Kaçmaz K, Kamisuki Y, Bajorin DF.

Jpn J Clin Oncol. 2022 Oct 26:hyac155. doi: 10.1093/jjco/hyac155. Online ahead of print.

PMID: 36300304

 

Synthetic Access to α-Oxoketene Aminals by the Nucleophilic Addition of Enol Silane-Derived Palladium(II) Enolates to Carbodiimides.

Polimera SR, Ilangovan A, Meanwell NA, Subbaiah MAM.J Org Chem. 2022 Oct 26. doi: 10.1021/acs.joc.2c02107. Online ahead of print.

PMID: 36285601

 

Three-Component Asymmetric Ni-Catalyzed 1,2-Dicarbofunctionalization of Unactivated Alkenes via Stereoselective Migratory Insertion.

Apolinar O, Kang T, Alturaifi TM, Bedekar PG, Rubel CZ, Derosa J, Sanchez BB, Wong QN, Sturgell EJ, Chen JS, Wisniewski SR, Liu P, Engle KM.

J Am Chem Soc. 2022 Oct 26;144(42):19337-19343. doi: 10.1021/jacs.2c06636. Epub 2022 Oct 12.

PMID: 36222701

 

Autoimmune gene expression profiling of fingerstick whole blood in Chronic Fatigue Syndrome.

Wang Z, Waldman MF, Basavanhally TJ, Jacobs AR, Lopez G, Perichon RY, Ma JJ, Mackenzie EM, Healy JB, Wang Y, Hersey SA.

J Transl Med. 2022 Oct 25;20(1):486. doi: 10.1186/s12967-022-03682-3.

PMID: 36284352 

 

From Cold to Hot: Changing Perceptions and Future Opportunities for Quantitative Systems Pharmacology (QSP) Modeling in Cancer Immunotherapy.

Lemaire V, Bassen D, Reed M, Song R, Khalili S, Lien YTK, Huang L, Singh AP, Stamatelos S, Bottino D, Hua F.

Clin Pharmacol Ther. 2022 Oct 25. doi: 10.1002/cpt.2770. Online ahead of print.

PMID: 36282521

 

Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen.

Mandler MD, Suss N, Ramirez A, Farley CA, Aulakh D, Zhu Y, Traeger SC, Sarjeant A, Davies ML, Ellsworth BA, Regueiro-Ren A.

Org Lett. 2022 Oct 21;24(41):7643-7648. doi: 10.1021/acs.orglett.2c03133. Epub 2022 Oct 10.

PMID: 36214755

 

Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21.

Sychterz C, Gardner I, Chiang M, Rachumallu R, Neuhoff S, Perera V, Merali S, Schmidt BJ, Gaohua L.

Metabolites. 2022 Oct 20;12(10):1001. doi: 10.3390/metabo12101001.

PMID: 36295903

 

Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer.

Furcht C, VanSeveren M, Holstein M, Feroz H, Ghose S.

Biotechnol Prog. 2022 Oct 20:e3306. doi: 10.1002/btpr.3306. Online ahead of print.

PMID: 36264017

 

A Model to Estimate Cytokine Release Syndrome and Neurological Event Management Costs Associated With CAR T-Cell Therapy.

Badaracco J, Gitlin M, Keating SJ.

Transplant Cell Ther. 2022 Oct 19:S2666-6367(22)01704-3. doi: 10.1016/j.jtct.2022.10.009. Online ahead of print.

PMID: 36272529

 

Particle Property Characterization and Data Curation for Effective Powder Property Modeling in the Pharmaceutical Industry.

Wadams RC, Akseli I, Albrecht J, Ferreira AP, Gamble JF, Leane M, Thomas S, Schuman Y, Taylor L, Tobyn M.

AAPS PharmSciTech. 2022 Oct 19;23(8):286. doi: 10.1208/s12249-022-02434-2.

PMID: 36261755

 

The Effectiveness of Patient Training in Inflammatory Bowel Disease Knowledge via Instagram: Randomized Controlled Trial.

Blunck D, Kastner L, Nissen M, Winkler J.

J Med Internet Res. 2022 Oct 19;24(10):e36767. doi: 10.2196/36767.

PMID: 36260385

 

Use of Advanced Flexible Modeling Approaches for Survival Extrapolation from Early Follow-up Data in two Nivolumab Trials in Advanced NSCLC with Extended Follow-up.

Chaudhary MA, Edmondson-Jones M, Baio G, Mackay E, Penrod JR, Sharpe DJ, Yates G, Rafiq S, Johannesen K, Siddiqui MK, Vanderpuye-Orgle J, Briggs A.

Med Decis Making. 2022 Oct 19:272989X221132257. doi: 10.1177/0272989X221132257. Online ahead of print.

PMID: 36259353

 

Unexpected Stability of a Prodrug to Enzymatic Hydrolysis within a Hydrated HPMC Matrix Tablet.

Hanley S, Brown J, Timmins P, Davies C, Dennis A.

Pharmaceutics. 2022 Oct 18;14(10):2222. doi: 10.3390/pharmaceutics14102222.

PMID: 36297657

 

In-process Vapor Composition Monitoring in Application to Lyophilization of Ammonium Salt Formulations.

Strongrich AD, Tobyn M, Iyer L, Park Y, Hong J, Alexeenko AA.

J Pharm Sci. 2022 Oct 18:S0022-3549(22)00456-7. doi: 10.1016/j.xphs.2022.10.004. Online ahead of print.

PMID: 36270539

 

Safety, Pharmacokinetics, and Pharmacodynamics of CC-90001 (BMS-986360), a c-Jun N-terminal Kinase Inhibitor, in Phase 1 Studies in Healthy Participants.

Ye Y, Gaudy A, Thomas M, Reyes J, Burkhardt B, Horan G, Liu L, Chen J, Ghosh A, Carayannopoulos LN, Tatosian DA, Palmisano M.

Clin Pharmacol Drug Dev. 2022 Oct 18. doi: 10.1002/cpdd.1178. Online ahead of print.

PMID: 36256505

 

Identification of Rodent Husbandry Refinement Opportunities through Benchmarking and Collaboration.

Bratcher NA, Allen CM, McLahan CL, O'Connell DM, Burr HN, Keen JN, Stanislawczyk LM, Burns MA.

J Am Assoc Lab Anim Sci. 2022 Oct 17. doi: 10.30802/AALAS-JAALAS-21-000099. Online ahead of print.

PMID: 36253074

 

Structured expert elicitation to inform long-term survival extrapolations using alternative parametric distributions: a case study of CAR T therapy for relapsed/ refractory multiple myeloma.

Ayers D, Cope S, Towle K, Mojebi A, Marshall T, Dhanda D.

BMC Med Res Methodol. 2022 Oct 15;22(1):272. doi: 10.1186/s12874-022-01745-z.

PMID: 36243687

 

Prologue: Evidence Informing the GRAPPA 2021 Treatment Recommendations, by Domain.

Soriano ER, Kavanaugh A, Coates LC.

J Rheumatol. 2022 Oct 15:jrheum.220486. doi: 10.3899/jrheum.220486. Online ahead of print.

PMID: 36243414

 

Drs. Bessette and Kinch reply.

Bessette L, Kinch CD.

J Rheumatol. 2022 Oct 15:jrheum.220909. doi: 10.3899/jrheum.220909. Online ahead of print.

PMID: 36243412

 

Management of Peripheral Arthritis in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations.

Leung YY, Korotaeva TV, Candia L, Pedersen SJ, Molano WB, Ruderman EM, Bisoendial R, Perez-Alamino R, Olsder W, Möller B, Grazio S, Gudu T, Mody GM, Pineda C, Raffayova H, Rohekar S, Goldenstein-Schainberg C, Gutierrez Urena SR, Casasola Vargas JC, Meghnathi B, Prasad R, Richette P, Miranda JRS, Malliotis N, Lindqvist U, Simon D, Ezeonyeji A, Soriano ER, FitzGerald O.

J Rheumatol. 2022 Oct 15:jrheum.220315. doi: 10.3899/jrheum.220315. Online ahead of print.

PMID: 36243409 

 

Personalised paediatric chewable Ibuprofen tablets fabricated using 3D micro-extrusion printing technology.

Tabriz AG, Nandi U, Scoutaris N, Sanfo K, Alexander B, Gong Y, Hui HW, Kumar S, Douroumis D.

Int J Pharm. 2022 Oct 15;626:122135. doi: 10.1016/j.ijpharm.2022.122135. Epub 2022 Aug 24.

PMID: 36028083

 

NMR spectroscopy as a characterization tool enabling biologics formulation development.

Ma J, Pathirana C, Liu DQ, Miller SA.

J Pharm Biomed Anal. 2022 Oct 14;223:115110. doi: 10.1016/j.jpba.2022.115110. Online ahead of print.

PMID: 36308923 

 

Determination of ICH-Q3D Elemental Impurity Leachables in Glass Vials by Inductively Coupled Plasma-Mass Spectrometry.

Breckenridge L, Oni Y, Evans C, Franck J, Wood S, Xu M, Sahin E, Zacour B.

PDA J Pharm Sci Technol. 2022 Oct 14:pdajpst.2021.012655. doi: 10.5731/pdajpst.2021.012655. Online ahead of print.

PMID: 36241213

 

Payer formulary exclusions of apixaban: how patients respond and potential implications.

Deitelzweig S, Terasawa E, Kang A, Atreja N, Hines DM, Noman A, Luo X.

Curr Med Res Opin. 2022 Oct 14:1-6. doi: 10.1080/03007995.2022.2128189. Online ahead of print.

PMID: 36164763

 

Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents.

Torrens L, Puigvehí M, Torres-Martín M, Wang H, Maeda M, Haber PK, Leonel T, García-López M, Esteban-Fabró R, Leow WQ, Montironi C, Torrecilla S, Varadarajan AR, Taik P, Campreciós G, Enkhbold C, Taivanbaatar E, Yerbolat A, Villanueva A, Pérez-Del-Pulgar S, Thung S, Chinburen J, Letouzé E, Zucman-Rossi J, Uzilov A, Neely J, Forns X, Roayaie S, Sia D, Llovet JM.

Clin Cancer Res. 2022 Oct 14;28(20):4509-4520. doi: 10.1158/1078-0432.CCR-22-0632.

PMID: 35998012

 

Treatment patterns for advanced non-small cell lung cancer in the US: A systematic review of observational studies.

Lee A, Yuan Y, Eccles L, Chitkara A, Dalén J, Varol N.

Cancer Treat Res Commun. 2022 Oct 13;33:100648. doi: 10.1016/j.ctarc.2022.100648. Online ahead of print.

PMID: 36270164

 

Toxicologic Pathology Forum: Opinion on Not Euthanizing Control Animals in the Recovery Phase of Non-Rodent Toxicology Studies.

Janardhan KS, Sura R, Salian-Mehta S, Flandre T, Palazzi X, Zane D, Singh B, Jacob B, Hukkanen RR, Al-Haddawi M, Bennet B, Laast V, Lee D, Peterson R 2nd, Romeike A, Schorsch F, Guffroy M.

Toxicol Pathol. 2022 Oct 13:1926233221129214. doi: 10.1177/01926233221129214. Online ahead of print.

PMID: 36226581

 

Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay.

Cai X, Patel S, Huang C, Paiva A, Sun Y, Barker G, Weller H, Shou W.

Xenobiotica. 2022 Oct 13:1-9. doi: 10.1080/00498254.2022.2133648. Online ahead of print.

PMID: 36217915

 

Prognostic impact of NPM1 and FLT3 mutations in patients with AML in first remission treated with oral azacitidine.

Döhner H, Wei AH, Roboz GJ, Montesinos P, Thol FR, Ravandi F, Dombret H, Porkka K, Sandhu I, Skikne B, See WL, Ugidos M, Risueño A, Chan ET, Thakurta A, Beach CL, Lopes de Menezes D.

Blood. 2022 Oct 13;140(15):1674-1685. doi: 10.1182/blood.2022016293.

PMID: 35960871

 

Design of a Re-dispersible High Drug Load Amorphous Formulation.

Oberoi HS, Arce F, Purohit HS, Yu M, Fowler CA, Zhou D, Law D.

J Pharm Sci. 2022 Oct 12:S0022-3549(22)00455-5. doi: 10.1016/j.xphs.2022.10.002. Online ahead of print.

PMID: 36243131

 

Computational prediction of blend time in a large-scale viral inactivation process for monoclonal antibodies biomanufacturing.

Sirasitthichoke C, Hoang D, Phalak P, Armenante PM, Barnoon BI, Shandil I.

Biotechnol Bioeng. 2022 Oct 12. doi: 10.1002/bit.28264. Online ahead of print.

PMID: 36224707

 

Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.

Ansari-Pour N, Samur MK, Flynt E, Gooding S, Towfic F, Stong N, Ortiz Estevez M, Mavrommatis K, Walker BA, Morgan GJ, Munshi NC, Avet Loiseau H, Thakurta A.

Blood. 2022 Oct 12:blood.2022017010. doi: 10.1182/blood.2022017010. Online ahead of print.

PMID: 36223594

 

Five-Year Survival Outcomes With Nivolumab Plus Ipilimumab Versus Chemotherapy as First-Line Treatment for Metastatic Non-Small Cell Lung Cancer in CheckMate 227.

Brahmer JR, Lee JS, Ciuleanu TE, Caro RB, Nishio M, Urban L, Audigier-Valette C, Lupinacci L, Sangha R, Pluzanski A, Burgers J, Mahave M, Ahmed S, Schoenfeld AJ, Paz-Ares LG, Reck M, Borghaei H, O'Byrne KJ, Gupta RG, Bushong J, Li L, Blum SI, Eccles LJ, Ramalingam SS.

J Clin Oncol. 2022 Oct 12:101200JCO2201503. doi: 10.1200/JCO.22.01503. Online ahead of print.

PMID: 36223558

 

A Sterically Tuned Directing Auxiliary Promotes Catalytic 1,2-Carbofluorination of Alkenyl Carbonyl Compounds.

Liu Z, Oxtoby LJ, Sun J, Li ZQ, Kim N, Davies GHM, Engle KM.

Angew Chem Int Ed Engl. 2022 Oct 11. doi: 10.1002/anie.202214153. Online ahead of print.

PMID: 36221812

 

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in Acute Myeloid Leukemia.

Moujalled DM, Brown FC, Chua CC, Dengler MA, Pomilio G, Anstee NS, Litalien V, Thompson ER, Morley TD, MacRaild S, Tiong IS, Morris R, Dun K, Zordan AC, Shah JS, Banquet S, Halilovic E, Morris EJ, Herold MJ, Lessene GL, Adams JM, Huang DCS, Roberts AW, Blombery P, Wei AH.

Blood. 2022 Oct 11:blood.2022016090. doi: 10.1182/blood.2022016090. Online ahead of print.

PMID: 36219880

 

Design and economic investigation of a Multicolumn Countercurrent Solvent Gradient Purification unit for the separation of an industrially relevant PEGylated protein.

Kim TK, Sechi B, Romero Conde JJ, Angelo J, Xu X, Ghose S, Morbidelli M, Sponchioni M.

J Chromatogr A. 2022 Oct 11;1681:463487. doi: 10.1016/j.chroma.2022.463487. Epub 2022 Sep 7.

PMID: 36115185

 

Surface-induced protein aggregation and particle formation in biologics: current understanding of mechanisms, detection and mitigation strategies.

Kopp MRG, Grigolato F, Zürcher D, Das TK, Chou D, Wuchner K, Arosio P.

J Pharm Sci. 2022 Oct 9:S0022-3549(22)00459-2. doi: 10.1016/j.xphs.2022.10.009. Online ahead of print.

PMID: 36223809

Iberdomide plus dexamethasone in heavily pretreated late-line relapsed or refractory multiple myeloma (CC-220-MM-001): a multicentre, multicohort, open-label, phase 1/2 trial.

Lonial S, Popat R, Hulin C, Jagannath S, Oriol A, Richardson PG, Facon T, Weisel K, Larsen JT, Minnema MC, Abdallah AO, Badros AZ, Knop S, Stadtmauer EA, Cheng Y, Amatangelo M, Chen M, Nguyen TV, Amin A, Peluso T, van de Donk NWCJ.

Lancet Haematol. 2022 Oct 6:S2352-3026(22)00290-3. doi: 10.1016/S2352-3026(22)00290-3. Online ahead of print.

PMID: 36209764

 

Detection of bisphenols in Indian surface water, tap water, and packaged drinking water using dispersive liquid-liquid microextraction: exposure assessment for health risk.

Karsauliya K, Bhateria M, Sonker AK, Yahavi C, Gautam SS, Karsauliya S, Singh SP.

Environ Sci Pollut Res Int. 2022 Oct 6. doi: 10.1007/s11356-022-23293-1. Online ahead of print.

PMID: 36201081

 

Estimating the prevalence, clinical characteristics, and treatment patterns of hypertrophic cardiomyopathy in Japan: A nationwide medical claims database study.

Terasaka N, Spanopoulos D, Miyagoshi H, Kubo T, Kitaoka H.

J Cardiol. 2022 Oct 5:S0914-5087(22)00247-7. doi: 10.1016/j.jjcc.2022.09.015. Online ahead of print.

PMID: 36208832 

 

Ozanimod as a novel oral small molecule therapy for the treatment of Crohn's disease: The YELLOWSTONE clinical trial program.

Feagan BG, Schreiber S, Afzali A, Rieder F, Hyams J, Kollengode K, Pearlman J, Son V, Marta C, Wolf DC, D'Haens GG.

Contemp Clin Trials. 2022 Oct 5;122:106958. doi: 10.1016/j.cct.2022.106958. Online ahead of print.

PMID: 36208720

 

Nivolumab versus placebo as adjuvant therapy for resected stage III melanoma: a propensity weighted indirect treatment comparison and number needed to treat analysis for recurrence-free survival and overall survival.

Weber JS, Poretta T, Stwalley BD, Sakkal LA, Du EX, Wang T, Chen Y, Wang Y, Betts KA, Shoushtari AN.

Cancer Immunol Immunother. 2022 Oct 5. doi: 10.1007/s00262-022-03302-5. Online ahead of print.

PMID: 36197494

 

Ligand-Enabled C-H Hydroxylation with Aqueous H2O2 at Room Temperature.

Li Z, Park HS, Qiao JX, Yeung KS, Yu JQ.

J Am Chem Soc. 2022 Oct 5;144(39):18109-18116. doi: 10.1021/jacs.2c08332. Epub 2022 Sep 22.

PMID: 36137252

 

Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab.

Thudium K, Selby M, Zorn JA, Rak G, Wang XT, Bunch RT, Hogan JM, Strop P, Korman AJ.

Cancer Immunol Res. 2022 Oct 4;10(10):1175-1189. doi: 10.1158/2326-6066.CIR-22-0057.

PMID: 35981087

 

Coexisting Alterations of MHC Class I Antigen Presentation and IFNγ Signaling Mediate Acquired Resistance of Melanoma to Post-PD-1 Immunotherapy.

Nielsen M, Presti M, Sztupinszki Z, Jensen AWP, Draghi A, Chamberlain CA, Schina A, Yde CW, Wojcik J, Szallasi Z, Crowther MD, Svane IM, Donia M.

Cancer Immunol Res. 2022 Oct 4;10(10):1254-1262. doi: 10.1158/2326-6066.CIR-22-0326.

PMID: 35969233

 

Synthesizing secondary data into survival analysis to improve estimation efficiency.

Chen C, Yu T, Shen B, Wang M.

Biom J. 2022 Oct 3. doi: 10.1002/bimj.202100326. Online ahead of print.

PMID: 36192158

 

Electrophilic Hydrazination of Cyclopropanols Using Azodicarboxylates via Copper(II) Catalysis: An Umpolung Strategy to Access β-Hydrazino Ketone Motifs.

Ramar T, Ilangovan A, Meanwell NA, Subbaiah MAM.

J Org Chem. 2022 Oct 3. doi: 10.1021/acs.joc.2c01980. Online ahead of print.

PMID: 36190309

 

Drug Survival of Apremilast for Psoriatic Arthritis in a Real-World Setting: A Single-Center Experience.

Foti R, Visalli E, Amato G, Dal Bosco Y, Foti R, Baccano G.

J Rheumatol. 2022 Oct 1:jrheum.220333. doi: 10.3899/jrheum.220333. Online ahead of print.

PMID: 36182113

 

A perspective on the current use of the phase distribution model for predicting milk-to-plasma drug concentration ratio.

Zhang M, Sychterz C, Chang M, Huang L, Schmidt BJ, Gaohua L.

CPT Pharmacometrics Syst Pharmacol. 2022 Oct 1. doi: 10.1002/psp4.12865. Online ahead of print.

PMID: 36181346

 

Six-Year Results From RELEVANCE: Lenalidomide Plus Rituximab (R2) Versus Rituximab-Chemotherapy Followed by Rituximab Maintenance in Untreated Advanced Follicular Lymphoma.

Morschhauser F, Nastoupil L, Feugier P, Schiano de Colella JM, Tilly H, Palomba ML, Bachy E, Fruchart C, Libby EN, Casasnovas RO, Flinn IW, Haioun C, Maisonneuve H, Ysebaert L, Bartlett NL, Bouabdallah K, Brice P, Ribrag V, Le Gouill S, Daguindau N, Guidez S, Pica GM, García-Sancho AM, López-Guillermo A, Larouche JF, Ando K, Gomes da Silva M, André M, Kalung W, Sehn LH, Izutsu K, Cartron G, Gkasiamis A, Crowe R, Xerri L, Fowler NH, Salles G.

J Clin Oncol. 2022 Oct 1;40(28):3239-3245. doi: 10.1200/JCO.22.00843. Epub 2022 Aug 10.

PMID: 35947804 

 

MPN-036 Treatment Failure and Transition to Next-Line Therapy in Myelofibrosis: A Modified Delphi Panel Approach.

Mascarenhas J, Nguyen H, Saunders A, Oliver L, Tomkinson H, Perry R, McBride A.

Clin Lymphoma Myeloma Leuk. 2022 Oct;22 Suppl 2:S323. doi: 10.1016/S2152-2650(22)01431-8.

PMID: 36163980

 

Rationale and design of the AXIOMATIC-SSP phase II trial: Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events for Secondary Stroke Prevention.

Sharma M, Molina CA, Toyoda K, Bereczki D, Kasner SE, Lutsep HL, Tsivgoulis G, Ntaios G, Czlonkowska A, Shuaib A, Amarenco P, Endres M, Diener HC, Gailani D, Kahl A, Donovan M, Perera V, Li D, Hankey GJ.

J Stroke Cerebrovasc Dis. 2022 Oct;31(10):106742. doi: 10.1016/j.jstrokecerebrovasdis.2022.106742. Epub 2022 Aug 27.

PMID: 36037679

 

Luspatercept for the treatment of anaemia in non-transfusion-dependent β-thalassaemia (BEYOND): a phase 2, randomised, double-blind, multicentre, placebo-controlled trial.

Taher AT, Cappellini MD, Kattamis A, Voskaridou E, Perrotta S, Piga AG, Filosa A, Porter JB, Coates TD, Forni GL, Thompson AA, Tartaglione I, Musallam KM, Backstrom JT, Esposito O, Giuseppi AC, Kuo WL, Miteva D, Lord-Bessen J, Yucel A, Zinger T, Shetty JK, Viprakasit V; BEYOND Investigators.

Lancet Haematol. 2022 Oct;9(10):e733-e744. doi: 10.1016/S2352-3026(22)00208-3. Epub 2022 Aug 22.

PMID: 36007538

 

Impact of immune checkpoint inhibitors on the management of locally advanced or metastatic non-small cell lung cancer in real-life practice in patients initiating treatment between 2015 and 2018 in France and Germany.

Griesinger F, Pérol M, Girard N, Durand-Zaleski I, Zacharias S, Bosquet L, Jänicke M, Quantin X, Groth A, Fleitz A, Calleja A, Patel S, Lacoin L, Daumont MJ, Penrod JR, Carroll R, Waldenberger D, Reynaud D, Thomas M, Chouaid C.

Lung Cancer. 2022 Oct;172:65-74. doi: 10.1016/j.lungcan.2022.08.001. Epub 2022 Aug 6.

PMID: 36007281 

 

Effect of fluconazole on the pharmacokinetics of a single dose of fedratinib in healthy adults.

Chen Y, Ogasawara K, Wood-Horrall R, Thomas M, Thomas M, He B, Liu L, Xue Y, Surapaneni S, Carayannopoulos LN, Zhou S, Palmisano M, Krishna G.

Cancer Chemother Pharmacol. 2022 Oct;90(4):325-334. doi: 10.1007/s00280-022-04464-w. Epub 2022 Aug 24.

PMID: 36001108

 

Real World-Evidence for Regulatory Use Decision Aid: An Interactive Tool To Inform Clinical Development and Regulatory Strategies.

Burns L, Kalesnik-Orszulak R, Spring R, Zeegers F, Rutstein M, Hukkelhoven M, Wruck L, O'Donnell J.

Adv Ther. 2022 Oct;39(10):4772-4778. doi: 10.1007/s12325-022-02257-4. Epub 2022 Aug 16.

PMID: 35972721

 

Analysis of cellular kinetic models suggest that physiologically based model parameters may be inherently, practically unidentifiable.

Brown LV, Coles MC, McConnell M, Ratushny AV, Gaffney EA.

J Pharmacokinet Pharmacodyn. 2022 Oct;49(5):539-556. doi: 10.1007/s10928-022-09819-7. Epub 2022 Aug 6.

PMID: 35933452

 

Association between Human Leukocyte Antigen Polymorphism and Human Papillomavirus Infection in Brazilian Women.

de Araujo-Souza PS, El-Zein M, Bolpetti ADN, Maciag PC, Rabachini T, Franco EL, Villa LL.

Sex Transm Dis. 2022 Sep 30. doi: 10.1097/OLQ.0000000000001718. Online ahead of print.

PMID: 36194829

 

Delayed type hypersensitivity reactions to various allergens may differently model inflammatory skin diseases.

Pavel AB, Del Duca E, Cheng J, Wu J, Ungar B, Estrada YD, Jack C, Maari C, Proulx ÉS, Ramirez-Valle F, Krueger JG, Bissonnette R, Guttman-Yassky E.

Allergy. 2022 Sep 30. doi: 10.1111/all.15538. Online ahead of print.

PMID: 36178084

 

Comparative non-persistence in the first year of treatment with oral anticoagulants in patients with atrial fibrillation: A French comprehensive nationwide study.

Danchin N, Steg G, Mahé I, Hanon O, Jacoud F, Nolin M, Dalon F, Cotte FE, Gollety S, Van Ganse E, Belhassen M.

Arch Cardiovasc Dis. 2022 Sep 29:S1875-2136(22)00174-7. doi: 10.1016/j.acvd.2022.06.006. Online ahead of print.

PMID: 36257903

 

Design and conduct considerations for studies in patients with hepatic impairment.

Ravenstijn P, Chetty M, Manchandani P, Elmeliegy M, Qosa H, Younis I.

Clin Transl Sci. 2022 Sep 29. doi: 10.1111/cts.13428. Online ahead of print.

PMID: 36176049

 

Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis.

Palkowitz MD, Laudadio G, Kolb S, Choi J, Oderinde MS, Ewing TE, Bolduc PN, Chen T, Zhang H, Cheng PTW, Zhang B, Mandler MD, Blasczak VD, Richter JM, Collins MR, Schioldager RL, Bravo M, Dhar TGM, Vokits B, Zhu Y, Echeverria PG, Poss MA, Shaw SA, Clementson S, Petersen NN, Mykhailiuk PK, Baran PS.

J Am Chem Soc. 2022 Sep 28;144(38):17709-17720. doi: 10.1021/jacs.2c08006. Epub 2022 Sep 15.

PMID: 36106767

 

Adjuvant Therapy of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Patients With Resected Stage IIIB-D or Stage IV Melanoma (CheckMate 915).

Weber JS, Schadendorf D, Del Vecchio M, Larkin J, Atkinson V, Schenker M, Pigozzo J, Gogas H, Dalle S, Meyer N, Ascierto PA, Sandhu S, Eigentler T, Gutzmer R, Hassel JC, Robert C, Carlino MS, Di Giacomo AM, Butler MO, Muñoz-Couselo E, Brown MP, Rutkowski P, Haydon A, Grob JJ, Schachter J, Queirolo P, de la Cruz-Merino L, van der Westhuizen A, Menzies AM, Re S, Bas T, de Pril V, Braverman J, Tenney DJ, Tang H, Long GV.

J Clin Oncol. 2022 Sep 26:JCO2200533. doi: 10.1200/JCO.22.00533. Online ahead of print.

PMID: 36162037

 

Role of harvest depth filtration in controlling product-related impurities for a bispecific antibody.

Espah Borujeni E, Jin W, Shao C, Chennamsetty N, Xu X, Ghose S.

Antib Ther. 2022 Sep 26;5(4):268-279. doi: 10.1093/abt/tbac023. eCollection 2022 Oct.

PMID: 36299416 

 

Health-related quality of life with lisocabtagene maraleucel vs standard of care in relapsed or refractory LBCL.

Abramson JS, Johnston PB, Kamdar M, Ibrahimi S, Izutsu K, Arnason JE, Glass B, Mutsaers PGNJ, Lunning M, Braverman J, Liu FF, Crotta A, Montheard S, Previtali A, Guo S, Shi L, Solomon SR.

Blood Adv. 2022 Sep 23:bloodadvances.2022008106. doi: 10.1182/bloodadvances.2022008106. Online ahead of print.

PMID: 36149968

 

Effectiveness and safety of apixaban vs warfarin among venous thromboembolism patients at high-risk of bleeding.

Cohen AT, Sah J, Dhamane AD, Lee T, Rosenblatt L, Hlavacek P, Emir B, Keshishian A, Yuce H, Luo X.

PLoS One. 2022 Sep 23;17(9):e0274969. doi: 10.1371/journal.pone.0274969. eCollection 2022.

PMID: 36149864

 

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

Regueiro-Ren A, Sit SY, Chen Y, Chen J, Swidorski JJ, Liu Z, Venables BL, Sin N, Hartz RA, Protack T, Lin Z, Zhang S, Li Z, Wu DR, Li P, Kempson J, Hou X, Gupta A, Rampulla R, Mathur A, Park H, Sarjeant A, Benitex Y, Rahematpura S, Parker D, Phillips T, Haskell R, Jenkins S, Santone KS, Cockett M, Hanumegowda U, Dicker I, Meanwell NA, Krystal M.

J Med Chem. 2022 Sep 22;65(18):11927-11948. doi: 10.1021/acs.jmedchem.2c00879. Epub 2022 Aug 31.

PMID: 36044257

 

Preclinical Characterization and Phase 1 Study of an Anti-HER2-TLR7 Immune-Stimulator Antibody Conjugate in Patients with HER2+ Malignancies.

Janku F, Han SW, Doi T, Amatu A, Ajani JA, Kuboki Y, Cortez A, Cellitti SE, Mahling PC, Subramanian K, Schoenfeld HA, Choi SM, Iaconis LA, Lee LH, Pelletier MR, Dranoff G, Askoxylakis V, Siena S.

Cancer Immunol Res. 2022 Sep 21:CIR-21-0722. doi: 10.1158/2326-6066.CIR-21-0722. Online ahead of print.

PMID: 36129967

 

Leveraging patient-centric sampling for clinical drug development and decentralized clinical trials: Promise to reality.

Maass KF, Barfield MD, Ito M, James CA, Kavetska O, Kozinn M, Kumar P, Lepak M, Leuthold LA, Li W, Mikhailov D, Patel S, Perez NL, Jackson Rudd D, Vakkalagadda B, Williams TM, Zha J, Zhang X, Anderson MD.

Clin Transl Sci. 2022 Sep 21. doi: 10.1111/cts.13411. Online ahead of print.

PMID: 36129129

 

Is Intention to Treat Still the Gold Standard or Should Health Technology Assessment Agencies Embrace a Broader Estimands Framework?: Insights and Perspectives From the National Institute for Health and Care Excellence and Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen on the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use E9 (R1) Addendum.

Morga A, Latimer NR, Scott M, Hawkins N, Schlichting M, Wang J.

Value Health. 2022 Sep 20:S1098-3015(22)02148-9. doi: 10.1016/j.jval.2022.08.008. Online ahead of print.

PMID: 36150999

Grade 3/4 Adverse Event Costs of Immuno-oncology Combination Therapies for Previously Untreated Advanced Renal Cell Carcinoma.

McGregor B, Geynisman DM, Burotto M, Porta C, Suarez C, Bourlon MT, Del Tejo V, Du EX, Yang X, Sendhil SR, Betts KA, Huo S.

Oncologist. 2022 Sep 19:oyac186. doi: 10.1093/oncolo/oyac186. Online ahead of print.

PMID: 36124890

 

First-line nivolumab plus chemotherapy vs chemotherapy in patients with advanced gastric, gastroesophageal junction and esophageal adenocarcinoma: CheckMate 649 Chinese subgroup analysis.

Liu T, Bai Y, Lin X, Li W, Wang J, Zhang X, Pan H, Bai C, Bai L, Cheng Y, Zhang J, Zhong H, Ba Y, Hu W, Xu R, Guo W, Qin S, Yang N, Lu J, Shitara K, Lei M, Li M, Bao N, Chen T, Shen L.

Int J Cancer. 2022 Sep 19. doi: 10.1002/ijc.34296. Online ahead of print.

PMID: 36121651

 

Deep learning reveals predictive sequence concepts within immune repertoires to immunotherapy.

Sidhom JW, Oliveira G, Ross-MacDonald P, Wind-Rotolo M, Wu CJ, Pardoll DM, Baras AS.

Sci Adv. 2022 Sep 16;8(37):eabq5089. doi: 10.1126/sciadv.abq5089. Epub 2022 Sep 16.

PMID: 36112691

 

Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade.

Johannet P, Liu W, Fenyo D, Wind-Rotolo M, Krogsgaard M, Mehnert JM, Weber JS, Zhong J, Osman I.

Clin Cancer Res. 2022 Sep 15;28(18):4121-4130. doi: 10.1158/1078-0432.CCR-22-0404.

PMID: 36106402

 

Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, phase 3 POETYK PSO-2 trial.

Strober B, Thaçi D, Sofen H, Kircik L, Gordon KB, Foley P, Rich P, Paul C, Bagel J, Colston E, Throup J, Kundu S, Sekaran C, Linaberry M, Banerjee S, Papp KA.

J Am Acad Dermatol. 2022 Sep 14:S0190-9622(22)02643-3. doi: 10.1016/j.jaad.2022.08.061. Online ahead of print.

PMID: 36115523

 

Safety and efficacy of first-line nivolumab plus ipilimumab alternating with nivolumab monotherapy in patients with advanced renal cell carcinoma: the non-randomised, open-label, phase IIIb/IV CheckMate 920 trial.

George DJ, Spigel DR, Gordan LN, Kochuparambil ST, Molina AM, Yorio J, Rezazadeh Kalebasty A, McKean H, Tchekmedyian N, Tykodi SS, Zhang J, Askelson M, Johansen JL, Hutson TE.

BMJ Open. 2022 Sep 14;12(9):e058396. doi: 10.1136/bmjopen-2021-058396.

PMID: 36104138

 

Molecular Mechanisms of Desensitization Underlying the Differential Effects of Formyl Peptide Receptor 2 Agonists on Cardiac Structure-Function Post Myocardial Infarction.

Lupisella J, St-Onge S, Carrier M, Cook EM, Wang T, Sum C, Fernando G, Apgar K, Zhang R, Carson N, Snyder BJ, Ryan CS, Ma X, Dierks EA, Little S, Kick EK, Wurtz NR, Bouvier M, Héroux M, Garcia RA.

ACS Pharmacol Transl Sci. 2022 Sep 14;5(10):892-906. doi: 10.1021/acsptsci.2c00042. eCollection 2022 Oct 14.

PMID: 36268126

 

Photochemical Identification of Auxiliary Severe Acute Respiratory Syndrome Coronavirus 2 Host Entry Factors Using μMap.

Suzuki S, Geri JB, Knutson SD, Bell-Temin H, Tamura T, Fernández DF, Lovett GH, Till NA, Heller BL, Guo J, MacMillan DWC, Ploss A.

J Am Chem Soc. 2022 Sep 14;144(36):16604-16611. doi: 10.1021/jacs.2c06806. Epub 2022 Sep 1.

PMID: 36049228

 

Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus.

Sangesland M, Torrents de la Peña A, Boyoglu-Barnum S, Ronsard L, Mohamed FAN, Moreno TB, Barnes RM, Rohrer D, Lonberg N, Ghebremichael M, Kanekiyo M, Ward A, Lingwood D.Immunity. 2022 Sep 13;55(9):1693-1709.e8. doi: 10.1016/j.immuni.2022.07.006. Epub 2022 Aug 10.PMID: 35952670

 

A natural history of lower-risk myelodysplastic syndromes with ring sideroblasts: an analysis of the MDS-CAN registry.

Buckstein R, Chodirker L, Mozessohn L, Yee KWL, Geddes M, Zhu N, Shamy A, Leitch HA, Christou G, Banerji V, Brian L, Khalaf D, St-Hilaire E, Finn N, Nevill T, Keating MM, Storring J, Delage R, Parmentier A, Thambipillai A, Siddiqui M, Westcott C, Cameron C, Mamedov A, Spin P, Tang D.

Leuk Lymphoma. 2022 Sep 12:1-10. doi: 10.1080/10428194.2022.2109154. Online ahead of print.

PMID: 36095125

 

Attribute Analytics Performance Metrics from the MAM Consortium Interlaboratory Study.

Mouchahoir T, Schiel JE, Rogers R, Heckert A, Place BJ, Ammerman A, Li X, Robinson T, Schmidt B, Chumsae CM, Li X, Manuilov AV, Yan B, Staples GO, Ren D, Veach AJ, Wang D, Yared W, Sosic Z, Wang Y, Zang L, Leone AM, Liu P, Ludwig R, Tao L, Wu W, Cansizoglu A, Hanneman A, Adams GW, Perdivara I, Walker H, Wilson M, Brandenburg A, DeGraan-Weber N, Gotta S, Shambaugh J, Alvarez M, Yu XC, Cao L, Shao C, Mahan A, Nanda H, Nields K, Nightlinger N, Niu B, Wang J, Xu W, Leo G, Sepe N, Liu YH, Patel BA, Richardson D, Wang Y, Tizabi D, Borisov OV, Lu Y, Maynard EL, Gruhler A, Haselmann KF, Krogh TN, Sönksen CP, Letarte S, Shen S, Boggio K, Johnson K, Ni W, Patel H, Ripley D, Rouse JC, Zhang Y, Daniels C, Dawdy A, Friese O, Powers TW, Sperry JB, Woods J, Carlson E, Sen KI, Skilton SJ, Busch M, Lund A, Stapels M, Guo X, Heidelberger S, Kaluarachchi H, McCarthy S, Kim J, Zhen J, Zhou Y, Rogstad S, Wang X, Fang J, Chen W, Yu YQ, Hoogerheide JG, Scott R, Yuan H.

J Am Soc Mass Spectrom. 2022 Sep 7;33(9):1659-1677. doi: 10.1021/jasms.2c00129. Epub 2022 Aug 26.

PMID: 36018776

 

Kinetics of Surface Enrichment of a Polymer in a Glass-Forming Molecular Liquid.

Yu J, Yao X, Que C, Huang L, Hui HW, Gong Y, Qian F, Yu L.

Mol Pharm. 2022 Sep 5;19(9):3350-3357. doi: 10.1021/acs.molpharmaceut.2c00484. Epub 2022 Aug 19.

PMID: 35985030

 

How Dangerous Is Too Dangerous? A Perspective on Azide Chemistry.

Treitler DS, Leung S.

J Org Chem. 2022 Sep 2;87(17):11293-11295. doi: 10.1021/acs.joc.2c01402.

PMID: 36052475

 

Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.

Paul SM, Yohn SE, Popiolek M, Miller AC, Felder CC.

Am J Psychiatry. 2022 Sep;179(9):611-627. doi: 10.1176/appi.ajp.21101083. Epub 2022 Jun 27.

PMID: 35758639

 

Treatment and disease management patterns for bacillus Calmette-Guérin unresponsive nonmuscle invasive bladder cancer in North America, Europe and Asia: A real-world data analysis.

Broughton EI, Chun DS, Gooden KM, Mycock KL, Rajkovic I, Taylor-Stokes G.

Curr Urol. 2022 Sep;16(3):147-153. doi: 10.1097/CU9.0000000000000072. Epub 2022 Aug 2.

PMID: 36204362 

 

Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction.

Javaheri A, Diab A, Zhao L, Qian C, Cohen JB, Zamani P, Kumar A, Wang Z, Ebert C, Maranville J, Kvikstad E, Basso M, van Empel V, Richards AM, Doughty RN, Rietzschel E, Kammerhoff K, Gogain J, Schafer P, Seiffert DA, Gordon DA, Ramirez-Valle F, Mann DL, Cappola TP, Chirinos JA.

Circ Heart Fail. 2022 Sep;15(9):e009693. doi: 10.1161/CIRCHEARTFAILURE.121.009693. Epub 2022 Aug 9.

PMID: 36126144

 

Epilogue to the Gerald Maggiora Festschrift: a tribute to an exemplary mentor, colleague, collaborator, and innovator.

Shanmugasundaram V, Bajorath J, Christoffersen RE, Petke JD, Howe WJ, Johnson MA, Agrafiotis DK, Lee P, Kuhn LA, Goodwin JT, Holloway MK, Doman TN, Walters WP, Schreyer S, Medina-Franco JL, Martinez-Mayorga K, Restifo LL.

J Comput Aided Mol Des. 2022 Sep;36(9):623-638. doi: 10.1007/s10822-022-00473-2. Epub 2022 Sep 17.

PMID: 36114380

 

Is IQWiG's 15% Threshold Universally Applicable in Assessing the Clinical Relevance of Patient-Reported Outcomes Changes? An ISPOR Special Interest Group Report.

Schlichting M, Hennig M, Rudell K, McLeod L, Bennett B, Shaw J, Doward L, Molsen-David E, Chassany O.

Value Health. 2022 Sep;25(9):1463-1468. doi: 10.1016/j.jval.2022.07.010.

PMID: 36049796

 

Cost-Utility of Nivolumab Plus Ipilimumab in First-Line Treatment of Advanced Melanoma in the United States: An Analysis Using Long-Term Overall Survival Data from Checkmate 067.

Baker T, Johnson H, Kotapati S, Moshyk A, Hamilton M, Kurt M, Paly VF.

Pharmacoecon Open. 2022 Sep;6(5):697-710. doi: 10.1007/s41669-022-00348-0. Epub 2022 Aug 25.

PMID: 36006606 

 

Adjuvant nivolumab versus ipilimumab (CheckMate 238 trial): Reassessment of 4-year efficacy outcomes in patients with stage III melanoma per AJCC-8 staging criteria.

Larkin J, Weber J, Del Vecchio M, Gogas H, Arance AM, Dalle S, Cowey CL, Schenker M, Grob JJ, Chiarion-Sileni V, Márquez-Rodas I, Butler MO, Di Giacomo AM, Middleton MR, De la Cruz-Merino L, Arenberger P, Atkinson V, Hill A, Fecher LA, Millward M, Khushalani NI, Queirolo P, Long GV, Lobo M, Askelson M, Ascierto PA, Mandalá M.

Eur J Cancer. 2022 Sep;173:285-296. doi: 10.1016/j.ejca.2022.06.041. Epub 2022 Aug 11.

PMID: 35964471

 

Treatment Patterns for Targeted Therapies, Non-Targeted Therapies, and Drug Holidays in Patients with Psoriasis.

Armstrong A, Xia Q, John AR, Patel V, Seigel L.

Dermatol Ther (Heidelb). 2022 Sep;12(9):2087-2103. doi: 10.1007/s13555-022-00775-1. Epub 2022 Aug 10.

PMID: 35947341 

 

Biomarkers and heart failure events in patients with atrial fibrillation in the ARISTOTLE trial evaluated by a multi-state model.

Aulin J, Hijazi Z, Lindbäck J, Alexander JH, Gersh BJ, Granger CB, Hanna M, Horowitz J, Lopes RD, McMurray JJV, Oldgren J, Siegbahn A, Wallentin L; ARISTOTLE Investigators.

Am Heart J. 2022 Sep;251:13-24. doi: 10.1016/j.ahj.2022.03.009. Epub 2022 May 13.

PMID: 35569564

 

Impact of apixaban treatment discontinuation on the risk of hospitalization among patients with nonvalvular atrial fibrillation and COVID-19.

Deitelzweig S, Zhu J, Jiang J, Luo X, Keshishian A, Ferri M, Rosenblatt L, Schuler P, Gutierrez C, Dhamane AD.

Curr Med Res Opin. 2022 Aug 30:1-6. doi: 10.1080/03007995.2022.2112871. Online ahead of print.

PMID: 36000258

 

Risk of stroke/systemic embolism, major bleeding, and associated costs in non-valvular atrial fibrillation patients who initiated apixaban, dabigatran, or rivaroxaban compared with warfarin in the United States medicare population: updated analysis.

Amin A, Keshishian A, Hines DM, Dina O, Le H, Rosenblatt L, Liu X, Zhang Q, Vo L.

Curr Med Res Opin. 2022 Aug 30:1-10. doi: 10.1080/03007995.2022.2115772. Online ahead of print.

PMID: 35993487

 

Safety of First-line Nivolumab Plus Ipilimumab in Patients With Metastatic Non-Small Cell Lung Cancer: A Pooled Analysis of CheckMate 227, CheckMate 568, and CheckMate 817.

Paz-Ares LG, Ciuleanu T, Pluzanski A, Lee JS, Gainor JF, Otterson GA, Audigier-Valette C, Ready N, Schenker M, Linardou H, Caro RB, Provencio M, Zurawski B, Lee KH, Kim SW, Caserta C, Ramalingam SS, Spigel DR, Brahmer JR, Reck M, O'Byrne KJ, Girard N, Popat S, Peters S, Memaj A, Nathan F, Aanur N, Borghaei H.

J Thorac Oncol. 2022 Aug 29:S1556-0864(22)01556-8. doi: 10.1016/j.jtho.2022.08.014. Online ahead of print.

PMID: 36049658

 

Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations.

Wang X, Kopec AK, Collinge M, David R, Grant C, Hardwick RN, Navratil A, Patel N, Rowan W, Marshall N.

ALTEX. 2022 Aug 29. doi: 10.14573/altex.2205311. Online ahead of print.

PMID: 36044561

 

New Development in Understanding Drug-Polymer Interactions in Pharmaceutical Amorphous Solid Dispersions from Solid-State Nuclear Magnetic Resonance.

Pugliese A, Tobyn M, Hawarden LE, Abraham A, Blanc F.

Mol Pharm. 2022 Aug 29. doi: 10.1021/acs.molpharmaceut.2c00479. Online ahead of print.

PMID: 36037249

 

Apixaban versus other anticoagulants in patients with nonvalvular fibrillation: a comparison of all-cause and event-related costs in real-life setting in France.

Belhassen M, Hanon O, Steg PG, Mahé I, Née M, Jacoud F, Dalon F, Cotté FE, Guitard-Dehoux D, Marant-Micallef C, Van Ganse E, Danchin N.

Eur J Health Econ. 2022 Aug 28. doi: 10.1007/s10198-022-01513-2. Online ahead of print.

PMID: 36030485

 

A Combined Rheological and Thermomechanical Analysis Approach for the Assessment of Pharmaceutical Polymer Blends.

Isreb M, Chalkia M, Gough T, Forbes RT, Timmins P.

Polymers (Basel). 2022 Aug 27;14(17):3527. doi: 10.3390/polym14173527.

PMID: 36080602 

 

Changes in primary care management of atrial fibrillation patients following the shift from warfarin to non-vitamin K antagonist oral anticoagulants: a Norwegian population based study.

Halvorsen S, Smith JA, Söderdahl F, Thuresson M, Solli O, Ulvestad M, Jonasson C.

BMC Prim Care. 2022 Aug 25;23(1):214. doi: 10.1186/s12875-022-01824-6.

PMID: 36008778 

 

Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.

Hawryluk N, Robinson D, Shen Y, Kyne G, Bedore M, Menon S, Canan S, von Geldern T, Townson S, Gokool S, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Dalvie D, Specht S, Hübner MP, Scandale I.

J Med Chem. 2022 Aug 25;65(16):11388-11403. doi: 10.1021/acs.jmedchem.2c00960. Epub 2022 Aug 16.

PMID: 35972896 

 

Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.

Liu C, Jalagam PR, Feng J, Wang W, Raja T, Sura MR, Manepalli RKVLP, Aliphedi BR, Medavarapu S, Nair SK, Muthalagu V, Natesan R, Gupta A, Beno B, Panda M, Ghosh K, Shukla JK, Sale H, Haldar P, Kalidindi N, Shah D, Patel D, Mathur A, Ellsworth BA, Cheng D, Regueiro-Ren A.

J Med Chem. 2022 Aug 25;65(16):11084-11099. doi: 10.1021/acs.jmedchem.2c00517. Epub 2022 Aug 15.

PMID: 35969688

 

Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.

A M Subbaiah M, Subramani L, Ramar T, Desai S, Sinha S, Mandlekar S, Kadow JF, Jenkins S, Krystal M, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Meanwell NA.

J Med Chem. 2022 Aug 25;65(16):11150-11176. doi: 10.1021/acs.jmedchem.2c00632. Epub 2022 Aug 11.

PMID: 35952307

 

BMS-986158, a Small Molecule Inhibitor of the Bromodomain and Extraterminal Domain Proteins, in Patients with Selected Advanced Solid Tumors: Results from a Phase 1/2a Trial.

Hilton J, Cristea M, Postel-Vinay S, Baldini C, Voskoboynik M, Edenfield W, Shapiro GI, Cheng ML, Vuky J, Corr B, Das S, Apfel A, Xu K, Kozicki M, Ünsal-Kaçmaz K, Hammell A, Wang G, Ravindran P, Kollia G, Esposito O, Coker S, Diamond JR.

Cancers (Basel). 2022 Aug 23;14(17):4079. doi: 10.3390/cancers14174079.

PMID: 36077617 

 

Long-Term Efficacy and Safety of Luspatercept for Anemia Treatment in Patients With Lower-Risk Myelodysplastic Syndromes: The Phase II PACE-MDS Study.

Platzbecker U, Götze KS, Kiewe P, Germing U, Mayer K, Radsak M, Wolff T, Chromik J, Sockel K, Oelschlägel U, Haase D, Illmer T, Al-Ali HK, Silling G, Reynolds JG, Zhang X, Attie KM, Shetty JK, Giagounidis A.

J Clin Oncol. 2022 Aug 23:JCO2102476. doi: 10.1200/JCO.21.02476. Online ahead of print.

PMID: 35998303

 

Population-based study of treatment and outcome of recurrent oesophageal or junctional cancer.

Pape M, Vissers PAJ, Bertwistle D, McDonald L, Beerepoot LV, van Berge Henegouwen MI, Lagarde SM, Mook S, Mohammad NH, Jeene PM, van Laarhoven HWM, Verhoeven RHA.

Br J Surg. 2022 Aug 23:znac290. doi: 10.1093/bjs/znac290. Online ahead of print.

PMID: 35998093

 

Identification of cognitive impairment, depression, and fatigue among multiple sclerosis patients in a large comprehensive care center: A mixed-methods, qualitative study.

Tornatore C, Ahmad A, Pham T, Gupte-Singh K, Wahid N, Lynch J, Pratt KJ.

Mult Scler Relat Disord. 2022 Aug 20;68:104117. doi: 10.1016/j.msard.2022.104117. Online ahead of print.

PMID: 36037754

 

Container Closure Integrity of Vial Primary Packaging Systems under Frozen Storage Conditions: A Case Study.

Oni Y, Franck J, Evans C, Paniagua D, Kulshrestha A, Mantri RV.

PDA J Pharm Sci Technol. 2022 Aug 19:pdajpst.2021.012719. doi: 10.5731/pdajpst.2021.012719. Online ahead of print.

PMID: 35987519

 

Location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of high-risk NDMM patients.

Stong N, Ortiz Estevez M, Towfic F, Samur MK, Agarwal A, Corre J, Flynt E, Munshi NC, Avet-Loiseau H, Thakurta A.

Blood. 2022 Aug 19:blood.2022016212. doi: 10.1182/blood.2022016212. Online ahead of print.

PMID: 35984902

 

CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production.

Gaur R, Mensah KA, Stricker J, Adams M, Parton A, Cedzik D, Connarn J, Thomas M, Horan G, Schafer P, Mair S, Palmisano M, Ramírez-Valle F.

Arthritis Res Ther. 2022 Aug 18;24(1):199. doi: 10.1186/s13075-022-02850-6.

PMID: 35982464

 

Model-based analysis for the population pharmacokinetics of iberdomide and its major active metabolite in healthy subjects and patients with relapsed and refractory multiple myeloma.

Cheng Y, Xue Y, Chen L, Masin M, Maciag P, Peluso T, Zhou S, Li Y.

Br J Clin Pharmacol. 2022 Aug 18. doi: 10.1111/bcp.15498. Online ahead of print.

PMID: 35981078

 

Prospective cohort study of psoriatic arthritis risk in patients with psoriasis in a real-world psoriasis registry.

Ogdie A, Harrison RW, McLean RR, Lin TC, Lebwohl M, Strober BE, Zhuo J, Patel V, Mease PJ.

J Am Acad Dermatol. 2022 Aug 17:S0190-9622(22)02543-9. doi: 10.1016/j.jaad.2022.07.060. Online ahead of print.

PMID: 35987397

 

Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease.

Venkataraman AV, Mansur A, Rizzo G, Bishop C, Lewis Y, Kocagoncu E, Lingford-Hughes A, Huiban M, Passchier J, Rowe JB, Tsukada H, Brooks DJ, Martarello L, Comley RA, Chen L, Schwarz AJ, Hargreaves R, Gunn RN, Rabiner EA, Matthews PM.

Sci Transl Med. 2022 Aug 17;14(658):eabk1051. doi: 10.1126/scitranslmed.abk1051. Epub 2022 Aug 17.

PMID: 35976998

 

Intensive behavioural interventions based on applied behaviour analysis (ABA) for young children with autism: A cost-effectiveness analysis.

Hodgson R, Biswas M, Palmer S, Marshall D, Rodgers M, Stewart L, Simmonds M, Rai D, Le Couteur A.

PLoS One. 2022 Aug 16;17(8):e0270833. doi: 10.1371/journal.pone.0270833. eCollection 2022.

PMID: 35972929 

 

Prevalence of psoriatic arthritis among patients with psoriasis in Italy.

Cazzaniga S, Heidemeyer K, Dondi L, Ronconi G, Pedrini A, Bellatreccia A, Zhong Y, Naldi L, Martini N.

J Eur Acad Dermatol Venereol. 2022 Aug 16. doi: 10.1111/jdv.18528. Online ahead of print.

PMID: 35972199

 

Women With Psoriatic Arthritis Experience Higher Disease Burden Than Men: Findings From a Real-World Survey in the United States and Europe.

Gossec L, Walsh JA, Michaud K, Peterson S, Holdsworth EA, Karyekar CS, Booth N, Chakravarty SD, Ogdie A.

J Rheumatol. 2022 Aug 15:jrheum.220154. doi: 10.3899/jrheum.220154. Online ahead of print.

PMID: 35970531

 

Impact of Physician-Defined Flares on Quality of Life and Work Impairment: An International Survey of 2,238 Psoriatic Arthritis Patients.

Orbai AM, Tillett W, Grieb S, Peterson S, Holdsworth E, Booth N, Chakravarty S, Gossec L.

J Rheumatol. 2022 Aug 15:jrheum.211302. doi: 10.3899/jrheum.211302. Online ahead of print.

PMID: 35970528

 

A Guide to Selecting Flexible Survival Models to Inform Economic Evaluations of Cancer Immunotherapies.

Palmer S, Borget I, Friede T, Husereau D, Karnon J, Kearns B, Medin E, Peterse EFP, Klijn SL, Verburg-Baltussen EJM, Fenwick E, Borrill J.

Value Health. 2022 Aug 13:S1098-3015(22)02105-2. doi: 10.1016/j.jval.2022.07.009. Online ahead of print.

PMID: 35970706

 

Investigating the feasibility of recruitment to an observational, quality-of-life study of patients diagnosed with atrial fibrillation (AF) who have experienced a bleed while anticoagulated: EQUAL-AF feasibility study protocol.

Hutchings HA, Lanyon K, Lister S, Alikhan R, Halcox J, Holland G, Hughes A, Jenkins R, Laing H, Lobban T, Owen D, Pollock KG, Todd C, Wareham K.

Pilot Feasibility Stud. 2022 Aug 12;8(1):180. doi: 10.1186/s40814-022-01135-8.

PMID: 35962446 

 

Elotuzumab Plus Pomalidomide and Dexamethasone for Relapsed/Refractory Multiple Myeloma: Final Overall Survival Analysis From the Randomized Phase II ELOQUENT-3 Trial.

Dimopoulos MA, Dytfeld D, Grosicki S, Moreau P, Takezako N, Hori M, Leleu X, LeBlanc R, Suzuki K, Raab MS, Richardson PG, Popa McKiver M, Jou YM, Yao D, Das P, San-Miguel J.

J Clin Oncol. 2022 Aug 12:JCO2102815. doi: 10.1200/JCO.21.02815. Online ahead of print.

PMID: 35960908

 

Ni/Photoredox-Catalyzed C(sp2)-C(sp3) Cross-Coupling of Alkyl Pinacolboronates and (Hetero)Aryl Bromides.

Cauley AN, Ramirez A, Barhate CL, Donnell AF, Khandelwal P, Sezen-Edmonds M, Sherwood TC, Sloane JL, Cavallaro CL, Simmons EM.

Org Lett. 2022 Aug 12;24(31):5663-5668. doi: 10.1021/acs.orglett.2c01942. Epub 2022 Aug 3.

PMID: 35920644

 

Neural Net Modeling of Checkpoint Inhibitor Related Myocarditis and Steroid Response.

Stefanovic F, Gomez-Caminero A, Jacobs DM, Subramanian P, Puzanov I, Chilbert MR, Feuerstein SG, Yatsynovich Y, Switzer B, Schentag JJ.

Clin Pharmacol. 2022 Aug 10;14:69-90. doi: 10.2147/CPAA.S369008. eCollection 2022.

PMID: 35975122

 

The win odds: statistical inference and regression.

Song J, Verbeeck J, Huang B, Hoaglin DC, Gamalo-Siebers M, Seifu Y, Wang D, Cooner F, Dong G.

J Biopharm Stat. 2022 Aug 10:1-11. doi: 10.1080/10543406.2022.2089156. Online ahead of print.

PMID: 35946932

 

Association between transfusion status and clinical and economic outcomes in patients with myelodysplastic syndromes from the physicians' perspective.

Gupta S, Kulasekararaj AG, Costantino H, Grisolano J, Tang J, Jones S, Tang D.

Cancer Rep (Hoboken). 2022 Aug 9:e1680. doi: 10.1002/cnr2.1680. Online ahead of print.

PMID: 35942648

 

Higher doses of tisagenlecleucel associate with improved outcomes: a report from the pediatric real-world CAR consortium.

Stefanski H, Eaton A, Baggott C, Rossoff J, Verneris MR, Keating AK, Prabhu S, Pacenta HL, Phillips CL, Talano JA, Moskop A, Margossian SP, Myers GD, Karras NA, Brown PA, Qayed M, Hermiston ML, Satwani P, Krupski C, Wilcox R, Rabik CA, Fabrizio VA, Chinnabhandar V, Goksenin AY, Egeler E, Mavroukakis S, Curran KJ, Mackall CL, Laetsch TW, Schultz LM.

Blood Adv. 2022 Aug 8:bloodadvances.2022007246. doi: 10.1182/bloodadvances.2022007246. Online ahead of print.

PMID: 35938863

 

ELIMINATOR: essentiality analysis using multisystem networks and integer programming.

Antoranz A, Ortiz M, Pey J.

BMC Bioinformatics. 2022 Aug 6;23(1):324. doi: 10.1186/s12859-022-04855-z.

PMID: 35933325

 

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.

Easton A, Jensen ML, Wang C, Hagedorn PH, Li Y, Weed M, Meredith JE, Guss V, Jones K, Gill M, Krause C, Brown JM, Hunihan L, Natale J, Fernandes A, Lu Y, Polino J, Bookbinder M, Cadelina G, Benitex Y, Sane R, Morrison J, Drexler D, Mercer SE, Bon C, Pandya NJ, Jagasia R, Ou Yang TH, Distler T, Grüninger F, Meldgaard M, Terrigno M, Macor JE, Albright CF, Loy J, Hoeg AM, Olson RE, Cacace AM.

Mol Ther Nucleic Acids. 2022 Aug 4;29:625-642. doi: 10.1016/j.omtn.2022.07.027. eCollection 2022 Sep 13.

PMID: 36090761

 

Real-world effectiveness of nivolumab plus ipilimumab and second-line therapy in Japanese untreated patients with metastatic renal cell carcinoma: 2-year analysis from a multicenter retrospective clinical study (J-cardinal study).

Kojima T, Kato R, Sazuka T, Yamamoto H, Fukuda S, Yamana K, Nakaigawa N, Sugino Y, Hamamoto S, Ito H, Murakami H, Obara W.

Jpn J Clin Oncol. 2022 Aug 3:hyac124. doi: 10.1093/jjco/hyac124. Online ahead of print.

PMID: 35920793

 

Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper.

Yang TY, Braun M, Lembke W, McBlane F, Kamerud J, DeWall S, Tarcsa E, Fang X, Hofer L, Kavita U, Upreti VV, Gupta S, Loo L, Johnson AJ, Chandode RK, Stubenrauch KG, Vinzing M, Xia CQ, Jawa V.

Mol Ther Methods Clin Dev. 2022 Aug 2;26:471-494. doi: 10.1016/j.omtm.2022.07.018. eCollection 2022 Sep 8.

PMID: 36092368 

 

External Quality Assessment 2.0: The Importance of a Standardized Implementation of TILs for Daily and Trial Practices.

Nauwelaers I, Laudus N, Peeters D, Acs B, Denkert C, Michiels S, Horlings H, Siziopikou KP, Ely S, Zardavas D, Mustimbo R, Bartlett J, Floris G, Hartman J, van Deurzen CHM, Ceusters D, Dequeker E, Salgado R.

Cancers (Basel). 2022 Aug 2;14(15):3762. doi: 10.3390/cancers14153762.

PMID: 35954426

 

Joint semiparametric models for case-cohort designs.

Zhong W, Diao G.

Biometrics. 2022 Aug 2. doi: 10.1111/biom.13728. Online ahead of print.

PMID: 35917392

 

Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL.

Hagner PR, Chiu H, Chopra VS, Colombo M, Patel N, Estevez MO, Waldman MF, Loos R, Towfic F, Gandhi AK.

Clin Cancer Res. 2022 Aug 2;28(15):3367-3377. doi: 10.1158/1078-0432.CCR-21-3347.

PMID: 35583604

 

Immune Checkpoint Blockade Outcome in Small-Cell Lung Cancer and Its Relationship With Retinoblastoma Mutation Status and Function.

Dowlati A, Abbas A, Chan T, Henick B, Wang X, Doshi P, Fu P, Patel J, Kuo F, Chang H, Balli D.

JCO Precis Oncol. 2022 Aug;6:e2200257. doi: 10.1200/PO.22.00257.

PMID: 36044718

 

Risk Levels and Adverse Clinical Outcomes Among Patients With Nonvalvular Atrial Fibrillation Receiving Oral Anticoagulants.

Lip GYH, Murphy RR, Sahiar F, Ingall TJ, Dhamane AD, Ferri M, Hlavacek P, Preib MT, Keshishian A, Russ C, Rosenblatt L, Yuce H, Deitelzweig S.

JAMA Netw Open. 2022 Aug 1;5(8):e2229333. doi: 10.1001/jamanetworkopen.2022.29333.

PMID: 36044214

 

Nivolumab plus rucaparib for metastatic castration-resistant prostate cancer: results from the phase 2 CheckMate 9KD trial.

Fizazi K, Retz M, Petrylak DP, Goh JC, Perez-Gracia J, Lacombe L, Zschäbitz S, Burotto M, Mahammedi H, Gravis G, Bastos DA, McCune SL, Vázquez Limón JC, Kwan EM, Castellano D, Fléchon A, Saad F, Grimm MO, Shaffer DR, Armstrong AJ, Bhagavatheeswaran P, Amin NP, Ünsal-Kaçmaz K, Wang X, Li J, Loehr A, Pachynski RK.

J Immunother Cancer. 2022 Aug;10(8):e004761. doi: 10.1136/jitc-2022-004761.

PMID: 35977756

 

Changes in Circulating Tumor DNA Reflect Clinical Benefit Across Multiple Studies of Patients With Non-Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors.

Vega DM, Nishimura KK, Zariffa N, Thompson JC, Hoering A, Cilento V, Rosenthal A, Anagnostou V, Baden J, Beaver JA, Chaudhuri AA, Chudova D, Fine AD, Fiore J, Hodge R, Hodgson D, Hunkapiller N, Klass DM, Kobie J, Peña C, Pennello G, Peterman N, Philip R, Quinn KJ, Raben D, Rosner GL, Sausen M, Tezcan A, Xia Q, Yi J, Young AG, Stewart MD, Carpenter EL, Aggarwal C, Allen J.

JCO Precis Oncol. 2022 Aug;6:e2100372. doi: 10.1200/PO.21.00372.

PMID: 35952319

 

(-)-Epicatechin Ameliorates Cardiac Fibrosis in a Female Rat Model of Pre-Heart Failure with Preserved Ejection Fraction.

Bustamante-Pozo M, Ramirez-Sanchez I, Garate-Carrillo A, Ito B, Navarrete V, Haro M, Garcia R, Carson N, Ceballos G, Villarreal F.

J Med Food. 2022 Aug;25(8):836-844. doi: 10.1089/jmf.2021.0158. Epub 2022 Aug 2.

PMID: 35917528

 

Validation of the Kansas City Cardiomyopathy Questionnaire in Symptomatic Obstructive Hypertrophic Cardiomyopathy.

Nassif M, Fine JT, Dolan C, Reaney M, Addepalli P, Allen VD, Sehnert AJ, Gosch K, Spertus JA.

JACC Heart Fail. 2022 Aug;10(8):531-539. doi: 10.1016/j.jchf.2022.03.002. Epub 2022 May 4.

PMID: 35902155

 

Pharmacokinetic Drug-Drug Interaction Studies Between Trilaciclib and Midazolam, Metformin, Rifampin, Itraconazole, and Topotecan in Healthy Volunteers and Patients with Extensive-Stage Small-Cell Lung Cancer.

Li C, Horton JK, Sale M, Curd L, Goti V, Tao W, Beelen A.

Clin Drug Investig. 2022 Aug;42(8):679-692. doi: 10.1007/s40261-022-01179-x. Epub 2022 Jul 16.

PMID: 35842567

 

Lisocabtagene maraleucel as second-line therapy in adults with relapsed or refractory large B-cell lymphoma who were not intended for haematopoietic stem cell transplantation (PILOT): an open-label, phase 2 study.

Sehgal A, Hoda D, Riedell PA, Ghosh N, Hamadani M, Hildebrandt GC, Godwin JE, Reagan PM, Wagner-Johnston N, Essell J, Nath R, Solomon SR, Champion R, Licitra E, Fanning S, Gupta N, Dubowy R, D'Andrea A, Wang L, Ogasawara K, Thorpe J, Gordon LI.

Lancet Oncol. 2022 Aug;23(8):1066-1077. doi: 10.1016/S1470-2045(22)00339-4. Epub 2022 Jul 12.

PMID: 35839786

 

An Industry Survey on Managing the Pharmacovigilance System Master File in a Global Environment: The Need for a Pragmatic Approach.

Lavery C, Emmott J, Jeck-Thole S, Rouben P, Usher D, van der Spuij W, Woodward L.

Pharmaceut Med. 2022 Aug;36(4):233-245. doi: 10.1007/s40290-022-00422-2. Epub 2022 Jun 20.

PMID: 35723862 

 

Increasing the Reuse of Protein Non-Naïve Nonhuman Primates in Pharmaceutical Drug Discovery and Development: An Overview and Industry Position on the Challenges and Benefits.

Mattis C, Bratcher N, Burns M, Carosino C, de Zafra C, Fancher RM, Georgi K, Graff C, Hukkanen RR, Johnson C, Lao Y, Lange A, Lee D, Lepherd M, Maguire S, Malisauskas M, Manuel M, Miranda S, Reed L, Santos R, Sayers B, Shaw D, Shuster D.

Int J Toxicol. 2022 Aug;41(4):291-296. doi: 10.1177/10915818221101791. Epub 2022 Jun 2.

PMID: 35656559

 

Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid.

Zhang Y, Chen SJ, Chen C, Chen XQ, Chatterjee S, Shuster DJ, Dexter H, Armstrong L, Joshi EM, Yang Z, Shen H.Drug Metab Dispos. 2022 Aug;50(8):1077-1086. doi: 10.1124/dmd.122.000875. Epub 2022 May 30.

PMID: 35636769

 

Proceedings from the Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Immune and Cellular Therapy in Multiple Myeloma.

Holstein SA, Asimakopoulos F, Azab AK, Bianchi G, Bhutani M, Crews LA, Cupedo T, Giles H, Gooding S, Hillengass J, John L, Kaiser S, Lee L, Maclachlan K, Pasquini MC, Pichiorri F, Shah N, Shokeen M, Shy BR, Smith EL, Verona R, Usmani SZ, McCarthy PL.

Transplant Cell Ther. 2022 Aug;28(8):446-454. doi: 10.1016/j.jtct.2022.05.019. Epub 2022 May 21.

PMID: 35605882

 

Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.

Parcella K, Patel M, Tu Y, Eastman K, Peese K, Gillis E, Belema M, Dicker IB, McAuliffe B, Ding B, Falk P, Simmermacher J, Parker DD, Sivaprakasam P, Khan JA, Kish K, Lewis H, Hanumegowda U, Jenkins S, Kadow JF, Krystal M, Meanwell NA, Naidu BN.

Bioorg Med Chem. 2022 Aug 1;67:116833. doi: 10.1016/j.bmc.2022.116833. Epub 2022 May 19.

PMID: 35605346

 

Diabetes-Related Complications and Costs in Medicare Beneficiaries with Comorbid Rheumatoid Arthritis and Diabetes Treated with Abatacept Versus Other Targeted DMARDs.

Patel V, Pulungan Z, Shah A, Jones B, Petrilla A, Ferri L, Han X, Michaud K.

Rheumatol Ther. 2022 Aug;9(4):1091-1107. doi: 10.1007/s40744-022-00453-w. Epub 2022 May 23.

PMID: 35604547 

 

Retention of subcutaneous abatacept for the treatment of rheumatoid arthritis: real-world results from the ASCORE study: an international 2-year observational study.

Alten R, Mariette X, Flipo RM, Caporali R, Buch MH, Patel Y, Marsal S, Sanmartí R, Nurmohamed MT, Griffiths H, Peichl P, Bannert B, Chartier M, Connolly SE, Lozenski K, Rauch C.

Clin Rheumatol. 2022 Aug;41(8):2361-2373. doi: 10.1007/s10067-022-06176-1. Epub 2022 May 10.

PMID: 35536413 

 

Enhanced aqueous dissolution of hydrophobic apixaban via direct incorporation of hydrophilic nanographene oxide.

Islam MS, Renner F, Foster K, Oderinde MS, Stefanski K, Mitra S.

Colloids Surf B Biointerfaces. 2022 Aug;216:112512. doi: 10.1016/j.colsurfb.2022.112512. Epub 2022 Apr 26.

PMID: 35533561

 

Oral tyrosine kinase 2 inhibitor PF-06826647 demonstrates efficacy and an acceptable safety profile in participants with moderate-to-severe plaque psoriasis in a phase 2b, randomized, double-blind, placebo-controlled study.

Tehlirian C, Singh RSP, Pradhan V, Roberts ES, Tarabar S, Peeva E, Vincent MS, Gale JD.

J Am Acad Dermatol. 2022 Aug;87(2):333-342. doi: 10.1016/j.jaad.2022.03.059. Epub 2022 Apr 6.

PMID: 35398218

 

Immunogenicity Risk Assessment of Spontaneously Occurring Therapeutic Monoclonal Antibody Aggregates.

Swanson MD, Rios S, Mittal S, Soder G, Jawa V.

Front Immunol. 2022 Jul 27;13:915412. doi: 10.3389/fimmu.2022.915412. eCollection 2022.

PMID: 35967308

 

Association of Use of Statins with Progression of Diabetic Retinopathy at a Tertiary Care Hospital in Southern India.

Priyadarshini P, Chogtu B, Bhandary SV, Kabirdev, Magazine R.

J Curr Ophthalmol. 2022 Jul 26;34(2):234-240. doi: 10.4103/joco.joco_70_21. eCollection 2022 Apr-Jun.

PMID: 36147261

 

Creating standards for liquid biopsies: the BLOODPAC experience.

Leiman LC, Baden J, D'Auria K, Lin CJ, Meier K.

Expert Rev Mol Diagn. 2022 Jul;22(7):677-679. doi: 10.1080/14737159.2022.2113059. Epub 2022 Aug 24.

PMID: 35979936

 

Longitudinal trends of peripheral blood counts in polycythaemia vera and essential thrombocythemia patients in the UK.

Carpenter L, Rockenschaub P, Hatton GB, D'Abrantes S, Sims E, Scott-Ram N, Ducès A, Emanuel G, Mead AJ, Drummond MW, Lipunova N.

EJHaem. 2022 Jun 29;3(3):785-793. doi: 10.1002/jha2.519. eCollection 2022 Aug.

PMID: 36051073

 

Aiding early clinical drug development by elucidation of the relationship between tumor growth inhibition and survival in relapsed/refractory multiple myeloma patients.

Cheng Y, Hong K, Chen N, Yu X, Peluso T, Zhou S, Li Y.

EJHaem. 2022 Jun 2;3(3):815-827. doi: 10.1002/jha2.494. eCollection 2022 Aug.

PMID: 36051011

 

Reply to T. Olivier et al.

Wolchok JD, Kluger H, Campigotto F, Larkin J, Hodi FS.

J Clin Oncol. 2022 May 10;40(14):1597-1598. doi: 10.1200/JCO.22.00209. Epub 2022 Mar 8.

PMID: 35258992

 

Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross-Coupling Enabled by Well-Defined Precatalysts with L,X-Type Ligands.

Mills LR, Gygi D, Ludwig JR, Simmons EM, Wisniewski SR, Kim J, Chirik PJ.

ACS Catal. 2022 Feb 4;12(3):1905-1918. doi: 10.1021/acscatal.1c05586. Epub 2022 Jan 20.

PMID: 36034100

 

Single-Dose Pharmacokinetics of Milvexian in Participants with Normal Renal Function and Participants with Moderate or Severe Renal Impairment.

Perera V, Abelian G, Li D, Wang Z, Zhang L, Lubin S, Bello A, Murthy B.

Clin Pharmacokinet. 2022 Jul 30. doi: 10.1007/s40262-022-01150-1. Online ahead of print.

PMID: 35906349

 

Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review.                                      Shah F, Huey K, Deshpande S, Turner M, Chitnis M, Schiller E, Yucel A, Moro Bueno L, Oliva EN.                                                             J Clin Med. 2022 Jul 30;11(15):4448. doi: 10.3390/jcm11154448.                                                                                       PMID: 35956067

Imaging the Alternatively Spliced D Domain of Tenascin C in a Preclinical Model of Inflammatory Bowel Disease.

Zhang L, Wang Y, Homan KT, Gaudette SM, McCluskey AJ, Chan Y, Murphy J, Abdalla M, Nelson CM, Sun VZ, Erickson JE, Knight HL, Clabbers A, Sterman AJS, Mitra S.

Mol Imaging Biol. 2022 Jul 29. doi: 10.1007/s11307-022-01758-6. Online ahead of print.

PMID: 35906512

 

Thalamic atrophy measured by artificial intelligence in a multicentre clinical routine real-word study is associated with disability progression.

Zivadinov R, Bergsland N, Jakimovski D, Weinstock-Guttman B, Benedict RHB, Riolo J, Silva D, Dwyer MG; DeepGRAI Registry Study group.

J Neurol Neurosurg Psychiatry. 2022 Jul 28:jnnp-2022-329333. doi: 10.1136/jnnp-2022-329333. Online ahead of print.

PMID: 35902228

 

Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium.

Rusyn I, Sakolish C, Kato Y, Stephan C, Vergara L, Hewitt P, Bhaskaran V, Davis M, Hardwick RN, Ferguson SS, Stanko JP, Bajaj P, Adkins K, Sipes NS, Hunter ES, Baltazar MT, Carmichael PL, Sadh K, Becker RA.

Toxicol Sci. 2022 Jul 28;188(2):143-152. doi: 10.1093/toxsci/kfac061.

PMID: 35689632

 

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference.

Schnabel RB, Marinelli EA, Arbelo E, Boriani G, Boveda S, Buckley CM, Camm AJ, Casadei B, Chua W, Dagres N, de Melis M, Desteghe L, Diederichsen SZ, Duncker D, Eckardt L, Eisert C, Engler D, Fabritz L, Freedman B, Gillet L, Goette A, Guasch E, Svendsen JH, Hatem SN, Haeusler KG, Healey JS, Heidbuchel H, Hindricks G, Hobbs FDR, Hübner T, Kotecha D, Krekler M, Leclercq C, Lewalter T, Lin H, Linz D, Lip GYH, Løchen ML, Lucassen W, Malaczynska-Rajpold K, Massberg S, Merino JL, Meyer R, Mont L, Myers MC, Neubeck L, Niiranen T, Oeff M, Oldgren J, Potpara TS, Psaroudakis G, Pürerfellner H, Ravens U, Rienstra M, Rivard L, Scherr D, Schotten U, Shah D, Sinner MF, Smolnik R, Steinbeck G, Steven D, Svennberg E, Thomas D, True Hills M, van Gelder IC, Vardar B, Palà E, Wakili R, Wegscheider K, Wieloch M, Willems S, Witt H, Ziegler A, Daniel Zink M, Kirchhof P.

Europace. 2022 Jul 27:euac062. doi: 10.1093/europace/euac062. Online ahead of print.

PMID: 35894842

 

Differential Surface Adsorption Phenomena for Conventional and Novel Surfactants Correlates with Changes in Interfacial mAb Stabilization.

Kanthe AD, Carnovale MR, Katz JS, Jordan S, Krause ME, Zheng S, Ilott A, Ying W, Bu W, Bera MK, Lin B, Maldarelli C, Tu RS.

Mol Pharm. 2022 Jul 26. doi: 10.1021/acs.molpharmaceut.2c00152. Online ahead of print.

PMID: 35882380

 

Real-World nivolumab dosing patterns and safety outcomes in patients receiving adjuvant therapy for melanoma.

Samlowski W, Robert NJ, Chen L, Schenkel B, Davis C, Moshyk A, Kotapati S, Poretta T, Weber JS.

Cancer Med. 2022 Jul 25. doi: 10.1002/cam4.5061. Online ahead of print.

PMID: 35880244

 

Bioactivation and Reactivity Research Advances - 2021 year in review.

Jackson KD, Argikar UA, Cho S, Crouch RD, Driscoll JP, Heck C, King L, Maw HH, Miller GP, Seneviratne HK, Wang S, Wei C, Zhang D, Khojasteh SC.

Drug Metab Rev. 2022 Jul 25:1-83. doi: 10.1080/03602532.2022.2097254. Online ahead of print.

PMID: 35876116

 

Patient experience before and after treatment with idecabtagene vicleucel (ide-cel, bb2121): qualitative analysis of patient interviews in the KarMMa trial.                                                                                                                                                                        Shah N, Delforge M, San-Miguel J, Moshkovich O, Braverman J, Dhanda DS, Lanar S, Miera M, Williams A, Murphy R, Devlen J, Hege K, Campbell TB, Munshi NC.                                                                                                                                                                   Leuk Res. 2022 Jul 21;120:106921. doi: 10.1016/j.leukres.2022.106921. Online ahead of print.                                           PMID: 35930999

PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib.

Ding X, Zhu Z, Lapek J, McMillan EA, Zhang A, Chung CY, Dubbury S, Lapira J, Firdaus S, Kang X, Gao J, Oyer J, Chionis J, Rollins RA, Li L, Niessen S, Bagrodia S, Zhang L, VanArsdale T.

Sci Rep. 2022 Jul 21;12(1):12501. doi: 10.1038/s41598-022-16623-3.

PMID: 35864202 

 

Optimization of antidote stocking, availability, and administration practices for a large multihospital organization.

Antoniello AA, Pauls P, Awad NI, Sobolewski K, Fernández D, Bridgeman P.

Am J Health Syst Pharm. 2022 Jul 21:zxac191. doi: 10.1093/ajhp/zxac191. Online ahead of print.

PMID: 35861156

 

One-Step Synthesis of β-Alkylidene-γ-lactones via Ligand-Enabled β,γ-Dehydrogenation of Aliphatic Acids.

Sheng T, Zhuang Z, Wang Z, Hu L, Herron AN, Qiao JX, Yu JQ.

J Am Chem Soc. 2022 Jul 20;144(28):12924-12933. doi: 10.1021/jacs.2c04779. Epub 2022 Jul 8.

PMID: 35802794

 

Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.

Petersson C, Zhou X, Berghausen J, Cebrian D, Davies M, DeMent K, Eddershaw P, Riedmaier AE, Leblanc AF, Manveski N, Marathe P, Mavroudis PD, McDougall R, Parrott N, Reichel A, Rotter C, Tess D, Volak LP, Xiao G, Yang Z, Baker J.

AAPS J. 2022 Jul 19;24(5):85. doi: 10.1208/s12248-022-00735-9.

PMID: 35854202 

 

Comparing patient global impression of severity and patient global impression of change to evaluate test-retest reliability of depression, non-small cell lung cancer, and asthma measures.

Eremenco S, Chen WH, Blum SI, Bush EN, Bushnell DM, DeBusk K, Gater A, Nelsen L, Coons SJ; PRO Consortium’s Communication Subcommittee.

Qual Life Res. 2022 Jul 19. doi: 10.1007/s11136-022-03180-5. Online ahead of print.

PMID: 35854060

 

Loss Of COP9-Signalosome Genes At 2q37 Is Associated With IMiD Agent Resistance In Multiple Myeloma.

Gooding S, Ansari-Pour N, Kazeroun MH, Karagoz K, Polonskaia A, Angulo Salazar M, Fitzsimons E, Sirinukunwattana K, Chavda SJ, Ortiz Estevez M, Towfic F, Flynt E, Pierceall W, Royston D, Yong KL, Ramasamy K, Vyas P, Thakurta A.

Blood. 2022 Jul 19:blood.2022015909. doi: 10.1182/blood.2022015909. Online ahead of print.

PMID: 35853156

 

Durvalumab as monotherapy and in combination therapy in patients with lymphoma or chronic lymphocytic leukemia: The FUSION NHL 001 trial.

Casulo C, Santoro A, Cartron G, Ando K, Munoz J, Le Gouill S, Izutsu K, Rule S, Lugtenburg P, Ruan J, Arcaini L, Casadebaig ML, Fox B, Kilavuz N, Rettby N, Dell'Aringa J, Taningco L, Delarue R, Czuczman M, Witzig T.

Cancer Rep (Hoboken). 2022 Jul 19:e1662. doi: 10.1002/cnr2.1662. Online ahead of print.

PMID: 35852004

 

Association of artificial intelligence-powered and manual quantification of programmed death-ligand 1 (PD-L1) expression with outcomes in patients treated with nivolumab ± ipilimumab.

Baxi V, Lee G, Duan C, Pandya D, Cohen DN, Edwards R, Chang H, Li J, Elliott H, Pokkalla H, Glass B, Agrawal N, Lahiri A, Wang D, Khosla A, Wapinski I, Beck A, Montalto M.

Mod Pathol. 2022 Jul 15. doi: 10.1038/s41379-022-01119-2. Online ahead of print.

PMID: 35840720

 

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.

Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG 3rd, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD Jr, Mullins RD, Eyquem J, Wells JA, Wiita AP.

Nat Commun. 2022 Jul 15;13(1):4121. doi: 10.1038/s41467-022-31810-6.

PMID: 35840578 

 

Challenges Encountered in the Implementation of Bio-Fluorescent Particle Counting Systems as a Routine Microbial Monitoring Tool.

Scott A, Vanbroekhoven A, Joossen C, Knutsen C, Govezensky D, Anders HJ, Cannon J, Salvas J, Dingle M, Hutchins P, Merker P, Villari P, Ramsey S, Cundell AM, Navarro V, Franz-Riethdorf M.

PDA J Pharm Sci Technol. 2022 Jul 15:pdajpst.2021.012726. doi: 10.5731/pdajpst.2021.012726. Online ahead of print.

PMID: 35840344

 

Impact of Fatigue on Health-Related Quality of Life and Work Productivity in Psoriatic Arthritis: Findings From a Real-World Survey.

Gossec L, Walsh JA, Michaud K, Holdsworth E, Peterson S, Meakin S, Yang F, Booth N, Chakravarty SD, Piercy J, Dennis N, Ogdie A.

J Rheumatol. 2022 Jul 15:jrheum.211288. doi: 10.3899/jrheum.211288. Online ahead of print.

PMID: 35840154

 

Development and validation of a self-administered questionnaire measuring essential knowledge in patients with axial spondyloarthritis.

Beauvais C, Pereira B, Pham T, Sordet C, Claudepierre P, Fayet F, Wendling D, Costantino F, Carton L, Grange L, Soubrier M, Legoupil N, Perdriger A, Tavares I, Dernis E, Gossec L, Rodère M.

J Rheumatol. 2022 Jul 15:jrheum.211314. doi: 10.3899/jrheum.211314. Online ahead of print.

PMID: 35840152

 

Low rate of subsequent malignant neoplasms following CAR T-cell therapy.

Hsieh EM, Myers RM, Yates B, Annesley C, John S, Taraseviciute A, Steinberg SM, Sheppard JD, Chung P, Chen L, Lee DW, DiNofia A, Grupp SA, Verneris MR, Laetsch TW, Bhojwani D, Brown PA, Pulsipher MA, Rheingold SR, Gardner RA, Gore L, Shah NN, Lamble A.

Blood Adv. 2022 Jul 14:bloodadvances.2022008093. doi:10.1182/bloodadvances.2022008093.Online ahead of print.

PMID: 35834728

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.

Priestley ES, Banville J, Deon D, Dubé L, Gagnon M, Guy J, Lapointe P, Lavallée JF, Martel A, Plamondon S, Rémillard R, Ruediger E, Tremblay F, Posy SL, Guarino VR, Richter JM, Li J, Gupta A, Vetrichelvan M, Balapragalathan TJ, Mathur A, Hua J, Callejo M, Guay J, Sum CS, Cvijic ME, Watson C, Wong P, Yang J, Bouvier M, Gordon DA, Wexler RR, Marinier A.

J Med Chem. 2022 Jul 14;65(13):8843-8854. doi: 10.1021/acs.jmedchem.2c00359. Epub 2022 Jun 21.

PMID: 35729784

 

Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis.

Nara SJ, Jogi S, Cheruku S, Kandhasamy S, Jaipuri F, Kathi PK, Reddy S, Sarodaya S, Cook EM, Wang T, Sitkoff D, Rossi KA, Ruzanov M, Kiefer SE, Khan JA, Gao M, Reddy S, Sivaprasad Lvj S, Sane R, Mosure K, Zhuo X, Cao GG, Ziegler M, Azzara A, Krupinski J, Soars MG, Ellsworth BA, Wacker DA.

J Med Chem. 2022 Jul 14;65(13):8948-8960. doi: 10.1021/acs.jmedchem.2c00165. Epub 2022 Jun 15.

PMID: 35704802

 

Applications of bio-predictive dissolution tools for the development of solid oral dosage forms: current industry experience.

Xu J, Zhang L, Shao X.

Drug Dev Ind Pharm. 2022 Jul 13:1-19. doi: 10.1080/03639045.2022.2098315. Online ahead of print.

PMID: 35786119 

 

Methodology-Centered Review of Molecular Modeling, Simulation, and Prediction of SARS-CoV-2.

Gao K, Wang R, Chen J, Cheng L, Frishcosy J, Huzumi Y, Qiu Y, Schluckbier T, Wei X, Wei GW.

Chem Rev. 2022 Jul 13;122(13):11287-11368. doi: 10.1021/acs.chemrev.1c00965. Epub 2022 May 20.

PMID: 35594413  

 

Comparison of Titer and Signal to Noise (S/N) for Determination of Anti-drug Antibody Magnitude Using Clinical Data from an Industry Consortium.

Starcevic Manning M, Hassanein M, Partridge MA, Jawa V, Mora J, Ryman J, Barker B, Braithwaite C, Carleton K, Hay L, Hottenstein C, Kubiak RJ, Devanarayan V.

AAPS J. 2022 Jul 12;24(4):81. doi: 10.1208/s12248-022-00728-8.

PMID: 35821280

 

Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy.

Desai MY, Owens A, Geske JB, Wolski K, Naidu SS, Smedira NG, Cremer PC, Schaff H, McErlean E, Sewell C, Li W, Sterling L, Lampl K, Edelberg JM, Sehnert AJ, Nissen SE.

J Am Coll Cardiol. 2022 Jul 12;80(2):95-108. doi: 10.1016/j.jacc.2022.04.048.

PMID: 35798455 

 

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.

Axelsson Raja A, Wakimoto H, DeLaughter DM, Reichart D, Gorham J, Conner DA, Lun M, Probst CK, Sakai N, Knipe RS, Montesi SB, Shea B, Adam LP, Leinwand LA, Wan W, Choi ES, Lindberg EL, Patone G, Noseda M, Hübner N, Seidman CE, Tager AM, Seidman JG, Ho CY.

Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2204174119. doi: 10.1073/pnas.2204174119. Epub 2022 Jul 5.

PMID: 35787042

 

Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial.

Armstrong AW, Gooderham M, Warren RB, Papp KA, Strober B, Thaçi D, Morita A, Szepietowski JC, Imafuku S, Colston E, Throup J, Kundu S, Schoenfeld S, Linaberry M, Banerjee S, Blauvelt A.

J Am Acad Dermatol. 2022 Jul 9:S0190-9622(22)02256-3. doi: 10.1016/j.jaad.2022.07.002. Online ahead of print.

PMID: 35820547

 

Oral anticoagulant underutilization among elderly patients with atrial fibrillation: insights from the United States Medicare database.

Munir MB, Hlavacek P, Keshishian A, Guo JD, Mallampati R, Ferri M, Russ C, Emir B, Cato M, Yuce H, Hsu JC.

J Interv Card Electrophysiol. 2022 Jul 9. doi: 10.1007/s10840-022-01274-1. Online ahead of print.

PMID: 35804258 

 

Design and preparation of N-linked hydroxypyridine-based APJ agonists.

Richter JM, Alex Bates J, Gargalovic P, Onorato JM, Generaux C, Wang T, Gordon DA, Wexler RR, Finlay HJ.

Bioorg Med Chem Lett. 2022 Jul 8;73:128882. doi: 10.1016/j.bmcl.2022.128882. Online ahead of print.

PMID: 35817293

 

Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma.

Denize T, Hou Y, Pignon JC, Walton E, West DJ, Freeman GJ, Braun DA, Wu CJ, Gupta S, Motzer RJ, Atkins MB, McDermott D, Choueiri TK, Shukla SA, Signoretti S.

Clin Cancer Res. 2022 Jul 8:ccr.22.0923. doi: 10.1158/1078-0432.CCR-22-0923. Online ahead of print.

PMID: 35802667

 

Longer-term benefit of luspatercept in transfusion-dependent lower-risk myelodysplastic syndromes with ring sideroblasts.

Zeidan AM, Platzbecker U, Garcia-Manero G, Sekeres MA, Fenaux P, DeZern AE, Greenberg PL, Savona MR, Jurcic JG, Verma A, Mufti Obe GJ, Buckstein RJ, Santini V, Shetty JK, Ito R, Zhang J, Zhang G, Ha X, Backstrom JT, Komrokji RS.

Blood. 2022 Jul 7:blood.2022016171. doi: 10.1182/blood.2022016171. Online ahead of print.

PMID: 35797468 

 

Ligand-Enabled β-C(sp3 )-H Lactamization of Tosyl-Protected Aliphatic Amides Using a Practical Oxidant.

Zhuang Z, Liu S, Cheng JT, Yeung KS, Qiao JX, Meanwell NA, Yu JQ.

Angew Chem Int Ed Engl. 2022 Jul 5:e202207354. doi: 10.1002/anie.202207354. Online ahead of print.

PMID: 35790471

 

Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.

Hill MD, Fang H, Norris D, Delucca GV, Huang H, DeBenedetto M, Quesnelle C, Schmitz WD, Tokarski JS, Sheriff S, Yan C, Fanslau C, Haarhoff Z, Huang C, Kramer M, Madari S, Menard K, Monereau L, Morrison J, Raghavan N, Shields EE, Simmermacher-Mayer J, Sinz M, Tye CK, Westhouse R, Xie C, Zhang H, Zhang L, Zvyaga T, Lee F, Gavai AV, Degnan AP.

ACS Med Chem Lett. 2022 Jul 5;13(7):1165-1171. doi: 10.1021/acsmedchemlett.2c00219. eCollection 2022 Jul 14.

PMID: 35859878

 

Trends in FDA Transporter-Based Post Marketing Requirements and Commitments Over the Last Decade.

Younis IR, Manchandani P, Hassan HE, Qosa H.

Clin Pharmacol Ther. 2022 Jul 3. doi: 10.1002/cpt.2701. Online ahead of print.

PMID: 35780478

 

hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss.

Alvarez Baron C, Thiebaud N, Ren M, Viatchenko-Karpinski S, Indapurkar A, King T, Matta MK, Ismaiel OA, Patel V, Mashaee M, Vicente J, Wu WW.

J Pharmacol Toxicol Methods. 2022 Jul 2:107193. doi: 10.1016/j.vascn.2022.107193. Online ahead of print.

PMID: 35792285

 

Adherence to Adjuvant Therapy in Patients with Resected Melanoma: An Application of the Theory of Planned Behavior.

Beisel C, Poretta T, Sheppard VB, Hurtado-de Mendoza A, Sipsma H, Fuqua E, Stwalley B, Salvatore A, Yang M.

Adv Ther. 2022 Jul 1. doi: 10.1007/s12325-022-02221-2. Online ahead of print.

PMID: 35776398

 

Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma.

Sudha P, Ahsan A, Ashby C, Kausar T, Khera A, Kazeroun MH, Hsu CC, Wang L, Fitzsimons E, Salminen O, Blaney P, Czader M, Williams J, Abu Zaid MI, Ansari-Pour N, Yong KL, van Rhee F, Pierceall WE, Morgan GJ, Flynt E, Gooding S, Abonour R, Ramasamy K, Thakurta A, Walker BA.

Clin Cancer Res. 2022 Jul 1;28(13):2854-2864. doi: 10.1158/1078-0432.CCR-21-3695.

PMID: 35522533 

 

Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke: A Post Hoc Analysis From the AUGUSTUS Trial.

Bahit MC, Vora AN, Li Z, Wojdyla DM, Thomas L, Goodman SG, Aronson R, Jordan JD, Kolls BJ, Dombrowski KE, Vinereanu D, Halvorsen S, Berwanger O, Windecker S, Mehran R, Granger CB, Alexander JH, Lopes RD.

JAMA Cardiol. 2022 Jul 1;7(7):682-689. doi: 10.1001/jamacardio.2022.1166. PMID: 35612866 

 

A comparison of the lowest effective concentration in culture media for detection of chromosomal damage in vitro and in blood or plasma for detection of micronuclei in vivo.

Kirkland D, Whitwell J, Smith R, Hashimoto K, Ji Z, Kenny J, Koyama N, Lovell DP, Martus HJ, Meurer K, Roberts D, Takeiri A, Uno Y, van der Leede BJ, White P, Zeller A.

Mutat Res Genet Toxicol Environ Mutagen. 2022 Jul-Aug;879-880:503503. doi: 10.1016/j.mrgentox.2022.503503. Epub 2022 May 28.

PMID: 35914859

 

Why 90% of clinical drug development fails and how to improve it?

Sun D, Gao W, Hu H, Zhou S.

Acta Pharm Sin B. 2022 Jul;12(7):3049-3062. doi: 10.1016/j.apsb.2022.02.002. Epub 2022 Feb 11.

PMID: 35865092  

 

Impact of apremilast on quality of life in Behçet's syndrome: analysis of the phase 3 RELIEF study.

Hatemi G, Mahr A, Takeno M, Kim D, Melikoğlu M, Cheng S, McCue S, Paris M, Chen M, Yazici Y.

RMD Open. 2022 Jul;8(2):e002235. doi: 10.1136/rmdopen-2022-002235.

PMID: 35798511  

  

Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer.

Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X, Sun SC.

Nat Cell Biol. 2022 Jul;24(7):1165-1176. doi: 10.1038/s41556-022-00942-8. Epub 2022 Jun 30.

PMID: 35773432

 

Longitudinal Psychometric Analysis of the Hypertrophic Cardiomyopathy Symptom Questionnaire (HCMSQ) Using Outcomes from the Phase III EXPLORER-HCM Trial.

Reaney M, Addepalli P, Allen V, Spertus JA, Dolan C, Sehnert AJ, Fine JT.

Pharmacoecon Open. 2022 Jul;6(4):575-586. doi: 10.1007/s41669-022-00340-8. Epub 2022 Jun 20.

PMID: 35718845 

 

Temporal Trends in Grade 3/4 Adverse Events and Associated Costs of Nivolumab Plus Cabozantinib Versus Sunitinib for Previously Untreated Advanced Renal Cell Carcinoma.

Geynisman DM, Burotto M, Porta C, Suarez C, Bourlon MT, Huo S, Del Tejo V, Du EX, Yang X, Betts KA, Choueiri TK, McGregor B.

Clin Drug Investig. 2022 Jul;42(7):611-622. doi: 10.1007/s40261-022-01170-6. Epub 2022 Jun 13.

PMID: 35696045 

 

Nivolumab plus cabozantinib versus sunitinib in first-line treatment for advanced renal cell carcinoma (CheckMate 9ER): long-term follow-up results from an open-label, randomised, phase 3 trial.

Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK.

Lancet Oncol. 2022 Jul;23(7):888-898. doi: 10.1016/S1470-2045(22)00290-X. Epub 2022 Jun 7.

PMID: 35688173 

 

An Open Label, Phase 1, Randomized, Seven-treatment, Seven-period, Crossover Study to Assess the Relative Bioavailability, pH Effect, Food Effect, and Dose Proportionality of CC-292, a Potent and Orally Available Bruton's Tyrosine Kinase Inhibitor.

Cheng Y, Liu L, Xue Y, Zhou S, Li Y.

Eur J Drug Metab Pharmacokinet. 2022 Jul;47(4):579-592. doi: 10.1007/s13318-022-00776-7. Epub 2022 Jun 3.

PMID: 35657581 

 

Development of the Hypertrophic Cardiomyopathy Symptom Questionnaire (HCMSQ): A New Patient-Reported Outcome (PRO) Instrument.

Reaney M, Allen V, Sehnert AJ, Fang L, Hagège AA, Naidu SS, Olivotto I.

Pharmacoecon Open. 2022 Jul;6(4):563-574. doi: 10.1007/s41669-022-00335-5. Epub 2022 Jun 2.

PMID: 35653062 

  

Disease-free survival as a surrogate endpoint for overall survival in adults with resectable esophageal or gastroesophageal junction cancer: A correlation meta-analysis.

Ajani JA, Leung L, Singh P, Kurt M, Kim I, Pourrahmat MM, Kanters S.

Eur J Cancer. 2022 Jul;170:119-130. doi: 10.1016/j.ejca.2022.04.027. Epub 2022 May 20.

PMID: 35605522

 

Compatibility rules of human enhancer and promoter sequences.

Bergman DT, Jones TR, Liu V, Ray J, Jagoda E, Siraj L, Kang HY, Nasser J, Kane M, Rios A, Nguyen TH, Grossman SR, Fulco CP, Lander ES, Engreitz JM.

Nature. 2022 Jul;607(7917):176-184. doi: 10.1038/s41586-022-04877-w. Epub 2022 May 20.

PMID: 35594906

 

Effectiveness and safety of oral anticoagulants in non-valvular atrial fibrillation patients with prior bleeding events: a retrospective analysis of administrative claims databases.

Lip GYH, Keshishian A, Kang A, Luo X, Atreja N, Zhang Y, Schuler P, Jiang J, Yuce H, Deitelzweig S.

J Thromb Thrombolysis. 2022 Jul;54(1):33-46. doi: 10.1007/s11239-022-02660-2. Epub 2022 May 17.

PMID: 35579733 

 

Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses.

Yang Z, Rajendran S, Spires V, Poirson B, Gururajan M, Lin Z, Arbanas J, Krystek S, Loy J, Cheng Y, Carl S, Pace S, Wang Y, Mehl J, Xu S, Vasudevan K, Broz M, Lehman-McKeeman L, Morin P, Graziano RF.

Drug Metab Dispos. 2022 Jul;50(7):898-908. doi: 10.1124/dmd.121.000799. Epub 2022 May 11.

PMID: 35545256

  

Statistical and Operational Considerations for 2-Stage Adaptive Designs with Simultaneous Evaluation of Overall and Marker-Selected Populations in Oncology Confirmatory Trials.

Zhang W, Ro S, Jiang Q, Li X, Liu R, Lu C', Marchenko O, Zhao J, Xu Z.

Ther Innov Regul Sci. 2022 Jul;56(4):552-560. doi: 10.1007/s43441-022-00407-y. Epub 2022 May 3.

PMID: 35503503 

 

End of induction positron emission tomography complete response (PET-CR) as a surrogate for progression-free survival in previously untreated follicular lymphoma.

Dixon JG, Dimier N, Nielsen T, Zheng J, Marcus R, Morschhauser F, Evens AM, Federico M, Blum KA, Shi Q.

Br J Haematol. 2022 Jul;198(2):333-337. doi: 10.1111/bjh.18217. Epub 2022 May 2.

PMID: 35491747

 

Combination elotuzumab and lenalidomide treatment efficacy is dependent on crosstalk between NK cells, monocytes and myeloma cells.

Richardson K, Keam SP, Zhu JJ, Meyran D, D'Souza C, Macdonald S, Campbell K, Robbins M, Bezman NA, Todd K, Quach H, Ritchie DS, Harrison SJ, Prince HM, Trapani JA, Jenkins MR, Beavis PA, Darcy PK, Neeson PJ.

Haematologica. 2022 Jun 30. doi: 10.3324/haematol.2021.279930. Online ahead of print.

PMID: 35770527

 

Quantification of Linrodostat and its metabolites: Overcoming bioanalytical challenges in support of a discovery Indoleamine 2,3 dioxygenase program.

Discenza LN, Balog A, Huang C, Moore R, Ranasinghe A, Lin TA, D'Arienzo C, Olah TV.

J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Jun 28;1207:123305. doi: 10.1016/j.jchromb.2022.123305. Online ahead of print.

PMID: 35839627

 

Long-term safety and efficacy of ozanimod in relapsing multiple sclerosis: Up to 5 years of follow-up in the DAYBREAK open-label extension trial.

Cree BA, Selmaj KW, Steinman L, Comi G, Bar-Or A, Arnold DL, Hartung HP, Montalbán X, Havrdová EK, Sheffield JK, Minton N, Cheng CY, Silva D, Kappos L, Cohen JA.

Mult Scler. 2022 Jun 28:13524585221102584. doi: 10.1177/13524585221102584. Online ahead of print.

PMID: 35765217

 

OzEAN Study to Collect Real-World Evidence of Persistent Use, Effectiveness, and Safety of Ozanimod Over 5 Years in Patients With Relapsing-Remitting Multiple Sclerosis in Germany.

Ziemssen T, Richter S, Mäurer M, Buttmann M, Kreusel B, Poehler AM, Lampl M, Linker RA.

Front Neurol. 2022 Jun 27;13:913616. doi: 10.3389/fneur.2022.913616. eCollection 2022.

PMID: 35832177 

 

Win statistics (win ratio, win odds, and net benefit) can complement one another to show the strength of the treatment effect on time-to-event outcomes.

Dong G, Huang B, Verbeeck J, Cui Y, Song J, Gamalo-Siebers M, Wang D, Hoaglin DC, Seifu Y, Mütze T, Kolassa J.

Pharm Stat. 2022 Jun 27. doi: 10.1002/pst.2251. Online ahead of print.

PMID: 35757986

 

New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans.

Merali S, Wang Z, Frost C, Callejo M, Hedrick M, Hui L, Meadows Shropshire S, Xu K, Bouvier M, DeSouza MM, Yang J.

Platelets. 2022 Jun 26:1-10. doi: 10.1080/09537104.2022.2088719. Online ahead of print.

PMID: 35758258

 

Nivolumab + low-dose ipilimumab in previously treated patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142.

André T, Lonardi S, Wong KYM, Lenz HJ, Gelsomino F, Aglietta M, Morse MA, Van Cutsem E, McDermott R, Hill A, Sawyer MB, Hendlisz A, Neyns B, Abdullaev S, Memaj A, Lei M, Dixon M, Kopetz S, Overman MJ.

Ann Oncol. 2022 Jun 25:S0923-7534(22)01737-9. doi: 10.1016/j.annonc.2022.06.008. Online ahead of print.

PMID: 35764271

 

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization.

Hawryluk N, Zhiru L, Carlow C, Gokool S, Townson S, Kreiss T, Chojnowski A, Prorok M, Siekierka J, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Canan S, Khetani V, Zeldis J, Specht S, Hübner MP, Scandale I.

Int J Parasitol Drugs Drug Resist. 2022 Jun 23;19:89-97. doi: 10.1016/j.ijpddr.2022.06.002. Online ahead of print.

PMID: 35834918 

 

Malignant pleural mesothelioma: treatment patterns and humanistic burden of disease in Europe.

Moore A, Bennett B, Taylor-Stokes G, McDonald L, Daumont MJ.

BMC Cancer. 2022 Jun 23;22(1):693. doi: 10.1186/s12885-022-09750-7.

PMID: 35739480 

 

Clinical activity of CC-90011, an oral, potent, and reversible LSD1 inhibitor, in advanced malignancies.

Hollebecque A, Salvagni S, Plummer R, Niccoli P, Capdevila J, Curigliano G, Moreno V, de Braud F, de Villambrosia SG, Martin-Romano P, Baudin E, Arias M, de Alvaro J, Parra-Palau JL, Sánchez-Pérez T, Aronchik I, Filvaroff EH, Lamba M, Nikolova Z, de Bono JS.

Cancer. 2022 Jun 23. doi: 10.1002/cncr.34366. Online ahead of print.

PMID: 35737639

 

Propensity score matching and stratification using multiparty data without pooling.

Wang J, Marion-Gallois R.

Pharm Stat. 2022 Jun 22. doi: 10.1002/pst.2250. Online ahead of print.

PMID: 35733398

 

Considerations for Human ADME strategy and design paradigm shift(s) - an Industry white paper.

Young GC, Spracklin DK, James AD, Hvenegaard MG, Scarfe G, Wagner DS, Georgi K, Schieferstein H, Bjornsdottir I, van Groen B, Romeo AA, Cassidy KC, Da-Violante G, Bister B, Blech S, Lyer R, Schulz SI, Cuyckens F, Moliner P.

Clin Pharmacol Ther. 2022 Jun 22. doi: 10.1002/cpt.2691. Online ahead of print.

PMID: 35733280

 

Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.

Dahlqvist J, Fulco CP, Ray JP, Liechti T, de Boer CG, Lieb DJ, Eisenhaure TM, Engreitz JM, Roederer M, Hacohen N.

Hum Mol Genet. 2022 Jun 22;31(12):1946-1961. doi: 10.1093/hmg/ddab372.

PMID: 34970970

 

Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein.

Yang Z, Loy J, Poirson B, Dai Y, Rajendran S, Xu S, Spires V, Gururajan M, Lin Z, Arbanas J, Carl S, Pace S, Wang Y, Mehl J, Vasudevan K, Spires T, Novosiadly R, Coker S, Perez R, Covello K, Morin P, Graziano R, Broz M, Lehman-McKeeman L.

Front Pharmacol. 2022 Jun 20;13:829063. doi: 10.3389/fphar.2022.829063. eCollection 2022.

PMID: 35795558 

 

An Evaluation of the Occupational Health Hazards of Peptide Couplers.

Graham JC, Trejo-Martin A, Chilton ML, Kostal J, Bercu J, Beutner GL, Bruen US, Dolan DG, Gomez S, Hillegass J, Nicolette J, Schmitz M.

Chem Res Toxicol. 2022 Jun 20;35(6):1011-1022. doi: 10.1021/acs.chemrestox.2c00031. Epub 2022 May 9.

PMID: 35532537 

 

Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial.

Kamdar M, Solomon SR, Arnason J, Johnston PB, Glass B, Bachanova V, Ibrahimi S, Mielke S, Mutsaers P, Hernandez-Ilizaliturri F, Izutsu K, Morschhauser F, Lunning M, Maloney DG, Crotta A, Montheard S, Previtali A, Stepan L, Ogasawara K, Mack T, Abramson JS; TRANSFORM Investigators.

Lancet. 2022 Jun 18;399(10343):2294-2308. doi: 10.1016/S0140-6736(22)00662-6.

PMID: 35717989 

 

Oral Cryotherapy for Oral Mucositis in Patients Receiving Busulfan: A Retrospective/Prospective Descriptive Study.

Grossman A, Froggatt N, Hendricks L, Kannenberg M, Klink K, Koch N, Reid K, Pitcher D, Bullock P, Neubauer J.

Oncol Nurs Forum. 2022 Jun 17;49(4):327-335. doi: 10.1188/22.ONF.327-335.

PMID: 35788737

 

Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5.

Selkirk JV, Bortolato A, Yan YG, Ching N, Hargreaves R.

Front Pharmacol. 2022 Jun 17;13:892097. doi: 10.3389/fphar.2022.892097. eCollection 2022.

PMID: 35784713 

 

Enasidenib vs conventional care in mutant-IDH2 relapsed/refractory acute myeloidleukemia: a randomized, phase 3 trial.

de Botton S, Montesinos P, Schuh A, Papayannidis C, Vyas P, Wei AH, Ommen HB, Semochkin S, Kim HJ, Larson RA, Koprivnikar J, Frankfurt O, Thol FR, Chromik J, Byrne JL, Pigneux A, Thomas X, Salamero O, Vidriales MB, Doronin VA, Döhner H, Fathi AT, Laille E, Yu X, Hasan M, Martín-Regueira P, DiNardo CD.

Blood. 2022 Jun 17:blood.2021014901. doi: 10.1182/blood.2021014901. Online ahead of print.

PMID: 35714312

 

Confirmatory efficacy testing for individual dose-placebo comparisons using serial gatekeeping procedure in dose-finding trials with multiple comparison procedures-modeling.

Yamaguchi Y, Sugitani T, Yoshida S, Maruo K.

Pharm Stat. 2022 Jun 16. doi: 10.1002/pst.2246. Online ahead of print.

PMID: 35708144

 

Correlations between objective response rate and survival-based endpoints in first-line advanced non-small cell lung Cancer: A systematic review and meta-analysis.

Goring S, Varol N, Waser N, Popoff E, Lozano-Ortega G, Lee A, Yuan Y, Eccles L, Tran P, Penrod JR.

Lung Cancer. 2022 Jun 15;170:122-132. doi: 10.1016/j.lungcan.2022.06.009. Online ahead of print.

PMID: 35767923

Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis.

Puengel T, Lefere S, Hundertmark J, Kohlhepp M, Penners C, Van de Velde F, Lapauw B, Hoorens A, Devisscher L, Geerts A, Boehm S, Zhao Q, Krupinski J, Charles ED, Zinker B, Tacke F.

Int J Mol Sci. 2022 Jun 15;23(12):6696. doi: 10.3390/ijms23126696.

PMID: 35743140 

 

Evaluation of patients with rheumatoid arthritis in teleconsultation during the first wave of the COVID-19 pandemic.

Avouac J, Molto A, Frantz C, Wanono S, Descamps E, Fogel O, Combier A, Poiroux L, Miceli-Richard C, Allanore Y.

J Rheumatol. 2022 Jun 15:jrheum.220073. doi: 10.3899/jrheum.220073. Online ahead of print.

PMID: 35705239

 

Long-term behavioral changes during the COVID-19 pandemic and impact of vaccination in patients with inflammatory rheumatic diseases.

Glintborg B, Jensen DV, Terslev L, Hendricks O, Østergaard M, Rasmussen SH, Pfeiffer Jensen M, Adelsten T, Colic A, Danebod K, Kildemand M, Loft AG, Munk HL, Pedersen JK, Østgård RD, Sørensen CM, Krogh NS, Agerbo JN, Ziegler C, Hetland ML.

J Rheumatol. 2022 Jun 15:jrheum.211280. doi: 10.3899/jrheum.211280. Online ahead of print.

PMID: 35705237

 

First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors.

Kim TW, Burris HA, de Miguel Luken MJ, Pishvaian MJ, Bang YJ, Gordon M, Awada A, Camidge DR, Hodi FS, McArthur GA, Miller WH, Cervantes A, Chow LQ, Lesokhin AM, Rutten A, Sznol M, Rishipathak D, Chen SC, Stefanich E, Pourmohamad T, Anderson M, Kim J, Huseni M, Rhee I, Siu LL.

Clin Cancer Res. 2022 Jun 14:clincanres.4020.2021. doi: 10.1158/1078-0432.CCR-21-4020. Online ahead of print.

PMID: 35699599

 

An overview of the BOIN design and its current extensions for novel early-phase oncology trials.

Ananthakrishnan R, Lin R, He C, Chen Y, Li D, LaValley M.

Contemp Clin Trials Commun. 2022 Jun 13;28:100943. doi: 10.1016/j.conctc.2022.100943. eCollection 2022 Aug.

PMID: 35812822

 

Preferences for and use of oral anticoagulants for stroke prevention in atrial fibrillation under real-world conditions in Germany: A survey among physicians.

Mocek A, Weber V, Schmölders J, Witt H, Gothe H.

Prev Med Rep. 2022 Jun 13;28:101861. doi: 10.1016/j.pmedr.2022.101861. eCollection 2022 Aug.

PMID: 35757576 

 

Endoscopic mucosal healing and histologic remission in ulcerative colitis: a systematic literature review of clinical, quality-of-life and economic outcomes.

Pandey A, Achrafie L, Kodjamanova P, Tencer T, Kumar J.

Curr Med Res Opin. 2022 Jun 11:1-11. doi: 10.1080/03007995.2022.2081453. Online ahead of print.

PMID: 35608153

 

Considerations and recommendations for assessment of plasma protein binding and drug-drug interactions for siRNA therapeutics.

Humphreys SC, Davis JA, Iqbal S, Kamel A, Kulmatycki K, Lao Y, Liu X, Rodgers J, Snoeys J, Vigil A, Weng Y, Wiethoff CM, Wittwer MB.

Nucleic Acids Res. 2022 Jun 10;50(11):6020-37. doi: 10.1093/nar/gkac456. Online ahead of print.

PMID: 35687098 

 

Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders.

Malona J, Chuaqui C, Seletsky BM, Beebe L, Cantin S, VAN Kalken D, Fahnoe K, Wang Z, Browning B, Szabo H, Koopman LA, Oravecz T, McDonald JJ, Ramirez-Valle F, Gaur R, Mensah KA, Thomas M, Connarn JN, Hu H, Alexander MD, Corin AF.

Transl Res. 2022 Jun 9:S1931-5244(22)00138-4. doi: 10.1016/j.trsl.2022.06.005. Online ahead of print.

PMID: 35691544

 

A statistical perspective on baseline adjustment in pharmacogenomic genome-wide association studies of quantitative change.

Zhang H, Chhibber A, Shaw PM, Mehrotra DV, Shen J.

NPJ Genom Med. 2022 Jun 9;7(1):33. doi: 10.1038/s41525-022-00303-2.

PMID: 35680959 

 

The Relevance of Experimental Charge Density Analysis in Unraveling Noncovalent Interactions in Molecular Crystals.

Thomas SP, Dikundwar AG, Sarkar S, Pavan MS, Pal R, Hathwar VR, Row TNG.

Molecules. 2022 Jun 8;27(12):3690. doi: 10.3390/molecules27123690.

PMID: 35744821

 

Propensity score-integrated approach to survival analysis: leveraging external evidence in single-arm studies.

Chen WC, Lu N, Wang C, Li H, Song C, Tiwari R, Xu Y, Yue LQ.

J Biopharm Stat. 2022 Jun 8:1-14. doi: 10.1080/10543406.2022.2080701. Online ahead of print.

PMID: 35675348

 

Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 2.

Meanwell NA, Loiseleur O.

J Agric Food Chem. 2022 Jun 8. doi: 10.1021/acs.jafc.2c00729. Online ahead of print.

PMID: 35675052 

 

Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 1.

Meanwell NA, Loiseleur O.

J Agric Food Chem. 2022 Jun 8. doi: 10.1021/acs.jafc.2c00726. Online ahead of print.

PMID: 35675050

 

Corrigendum: Selective Histone Deacetylase Inhibitor ACY-241 (Citarinostat) Plus Nivolumab in Advanced Non-Small Cell Lung Cancer: Results From a Phase Ib Study.

Awad MM, Le Bruchec Y, Lu B, Ye J, Miller JA, Lizotte PH, Cavanaugh ME, Rode AJ, Dumitru CD, Spira A.

Front Oncol. 2022 Jun 7;12:889996. doi: 10.3389/fonc.2022.889996. eCollection 2022.

PMID: 35747830 

 

Real-world disease-modifying therapy pathways from administrative claims data in patients with multiple sclerosis.

Fox RJ, Mehta R, Pham T, Park J, Wilson K, Bonafede M.

BMC Neurol. 2022 Jun 7;22(1):211. doi: 10.1186/s12883-022-02738-7.

PMID: 35672686 

 

Real-world treatment sequencing and survival in previously treated advanced renal cell carcinoma patients receiving nivolumab monotherapy: a UK retrospective cohort study.

Waddell T, Fife K, Griffiths R, Sharma A, Dhokia P, Groves L, Hurst M, Tsang C, Sugrue D, McKenna S, Houghton J, Carroll R.

BMC Cancer. 2022 Jun 6;22(1):617. doi: 10.1186/s12885-022-09694-y.

PMID: 35668384

Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome.

Ding R, Prasanna P, Corredor G, Barrera C, Zens P, Lu C, Velu P, Leo P, Beig N, Li H, Toro P, Berezowska S, Baxi V, Balli D, Belete M, Rimm DL, Velcheti V, Schalper K, Madabhushi A.

NPJ Precis Oncol. 2022 Jun 3;6(1):33. doi: 10.1038/s41698-022-00277-5.

PMID: 35661148 

 

Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development.

Lai Y, Chu X, Di L, Gao W, Guo Y, Liu X, Lu C, Mao J, Shen H, Tang H, Xia CQ, Zhang L, Ding X.

Acta Pharm Sin B. 2022 Jun;12(6):2751-2777. doi: 10.1016/j.apsb.2022.03.009. Epub 2022 Mar 17.

PMID: 35755285 

 

Calibration and validation of the rabbit model of electrolytic-mediated arterial thrombosis against the standard-of-care anticoagulant apixaban.

Wong PC, Crain E.

Pharmacol Res Perspect. 2022 Jun;10(3):e00963. doi: 10.1002/prp2.963.

PMID: 35680619 

 

Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity.

Gazal S, Weissbrod O, Hormozdiari F, Dey KK, Nasser J, Jagadeesh KA, Weiner DJ, Shi H, Fulco CP, O'Connor LJ, Pasaniuc B, Engreitz JM, Price AL.

Nat Genet. 2022 Jun;54(6):827-836. doi: 10.1038/s41588-022-01087-y. Epub 2022 Jun 6.

PMID: 35668300

 

Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial.

Padrón LJ, Maurer DM, O'Hara MH, O'Reilly EM, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Yu JX, Pfeiffer SM, Spasic M, Xu J, Gherardini PF, Karakunnel J, Mick R, Alanio C, Byrne KT, Hollmann TJ, Moore JS, Jones DD, Tognetti M, Chen RO, Yang X, Salvador L, Wherry EJ, Dugan U, O'Donnell-Tormey J, Butterfield LH, Hubbard-Lucey VM, Ibrahim R, Fairchild J, Bucktrout S, LaVallee TM, Vonderheide RH.

Nat Med. 2022 Jun;28(6):1167-1177. doi: 10.1038/s41591-022-01829-9. Epub 2022 Jun 3.

PMID: 35662283  

 

Addition of elotuzumab to lenalidomide and dexamethasone for patients with newly diagnosed, transplantation ineligible multiple myeloma (ELOQUENT-1): an open-label, multicentre, randomised, phase 3 trial.

Dimopoulos MA, Richardson PG, Bahlis NJ, Grosicki S, Cavo M, Beksaç M, Legieć W, Liberati AM, Goldschmidt H, Belch A, Magen H, Larocca A, Laubach JP, Petrucci MT, Reece D, White D, Mateos MV, Špička I, Lazaroiu M, Berdeja J, Kaufman JL, Jou YM, Ganetsky A, Popa McKiver M, Lonial S, Weisel K; ELOQUENT-1 investigators.

Lancet Haematol. 2022 Jun;9(6):e403-e414. doi: 10.1016/S2352-3026(22)00103-X. Epub 2022 May 9.

PMID: 35550060 

 

Impact of clinical pathways on treatment patterns and outcomes for patients with non-small-cell lung cancer: real-world evidence from a community oncology practice.

Dickson NR, Beauchamp KD, Perry TS, Roush A, Goldschmidt D, Edwards ML, Blakely LJ.

J Comp Eff Res. 2022 Jun;11(8):609-619. doi: 10.2217/cer-2021-0290. Epub 2022 May 12.

PMID: 35546311

 

Corrigendum to a cross-industry collaboration to assess if acute toxicity (Q)SAR models are fit-for-purpose for GHS classification and labelling. Regulatory toxicology and pharmacology (2021) 104843.

Bercu J, Masuda Herrera MJ, Trejo-Martin A, Hasselgren C, Lord J, Graham J, Schmitz M, Milchak L, Owens C, Lal SH, Robinson RM, Whalley S, Bellion P, Vuorinen A, Gromek K, Hawkins WA, Van de Gevel I, Vriens K, Kemper R, Naven R, Ferrer P, Myatt GJ.

Regul Toxicol Pharmacol. 2022 Jun;131:105165. doi: 10.1016/j.yrtph.2022.105165. Epub 2022 Apr 23.

PMID: 35474000  

 

Clinical development of antibody-drug conjugates in triple negative breast cancer: can we jump higher?

Zardavas D.

Expert Opin Investig Drugs. 2022 Jun;31(6):633-644. doi: 10.1080/13543784.2022.2070064. Epub 2022 May 2.

PMID: 35451891

 

Effects of Itraconazole and Diltiazem on the Pharmacokinetics and Pharmacodynamics of Milvexian, A Factor XIa Inhibitor.

Perera V, Wang Z, Lubin S, Christopher LJ, Chen W, Xu S, Seiffert D, DeSouza M, Murthy B.

Cardiol Ther. 2022 May 31. doi: 10.1007/s40119-022-00266-6. Online ahead of print.

PMID: 35641780

 

Dual-detection approach for a charge variant analysis of monoclonal antibody combination products using imaged capillary isoelectric focusing.

Candreva J, Esterman AL, Ge D, Patel P, Flagg SC, Das TK, Li X.

Electrophoresis. 2022 May 30. doi: 10.1002/elps.202200026. Online ahead of print.

PMID: 35634791

 

Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis.

Sun VZ, Melim TL, Mitra S, Erickson JE, Bryant SH, Farnham A, Westmoreland S, Knight H, Zhang L, Ritacco W, Homan K, Benatuil L, Sterman AJS, Goodearl AD.

Adv Rheumatol. 2022 May 27;62(1):17. doi: 10.1186/s42358-022-00247-2.

PMID: 35624488

 

Cost drivers associated with diffuse large B-cell lymphoma (DLBCL) in Japan: A structural equation model (SEM) analysis.

Tsutsué S, Makita S, Yi J, Crawford B.

PLoS One. 2022 May 27;17(5):e0269169. doi: 10.1371/journal.pone.0269169. eCollection 2022.

PMID: 35622820 

 

Phase 2 results of lisocabtagene maraleucel in Japanese patients with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma.

Makita S, Yamamoto G, Maruyama D, Asano-Mori Y, Kaji D, Ananthakrishnan R, Ogasawara K, Stepan L, Schusterbauer C, Rettby N, Hasskarl J, Izutsu K.

Cancer Med. 2022 May 26. doi: 10.1002/cam4.4820. Online ahead of print.

PMID: 35619325

 

Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists.

Wurtz NR, Johnson JA, Viet A, Shirude PS, Baligar V, Madduri S, Cheney DL, Park H, Lupisella JA, Hsu MY, Abousleiman M, Galella MA, Aulakh D, Dierks EA, Garcia RA, Ostrowski J, Kick EK, Wexler RR.

ACS Med Chem Lett. 2022 May 25;13(6):943-948. doi: 10.1021/acsmedchemlett.2c00079. eCollection 2022 Jun 9.

PMID: 35707160

 

Changing the drug development and therapeutic paradigm with biologic drug combinations and bispecifics: How to choose between these two approaches?

Zheng S, Prell R, Sheng J, Wang YM, Hamuro L.

Clin Transl Sci. 2022 May 25. doi: 10.1111/cts.13345. Online ahead of print.

PMID: 35611545 

 

The impact of phosphorylated PTEN at threonine 366 on cortical connectivity and behaviour.

Ledderose JMT, Benitez JA, Roberts AJ, Reed R, Bintig W, Larkum ME, Sachdev RNS, Furnari F, Eickholt BJ.

Brain. 2022 May 23:awac188. doi: 10.1093/brain/awac188. Online ahead of print.

PMID: 35603900

 

Impact of Lenalidomide Treatment on Overall Survival in Patients With Lower-Risk, Transfusion-Dependent Myelodysplastic Syndromes.

Santini V, Giagounidis A, Pelligra CG, Franco-Villalobos C, Tang D, Morison J, Beach CL, Hu A, Platzbecker U, Fenaux P.

Clin Lymphoma Myeloma Leuk. 2022 May 21:S2152-2650(22)00152-5. doi: 10.1016/j.clml.2022.05.001. Online ahead of print.

PMID: 35710702

 

Developing lisocabtagene maraleucel chimeric antigen receptor T-cell manufacturing for improved process, product quality and consistency across CD19+ hematologic indications.

Teoh J, Brown LF.

Cytotherapy. 2022 May 21:S1465-3249(22)00611-9. doi: 10.1016/j.jcyt.2022.03.013. Online ahead of print.

PMID: 35610089

 

The influence of a solvent environment on direct non-covalent interactions between two molecules: A symmetry-adapted perturbation theory study of polarization tuning of π-π interactions by water.

Sirianni DA, Zhu X, Sitkoff DF, Cheney DL, Sherrill CD.

J Chem Phys. 2022 May 21;156(19):194306. doi: 10.1063/5.0087302.

PMID: 35597646

 

Optimal adaptive promising zone designs.

Mehta C, Bhingare A, Liu L, Senchaudhuri P.

Stat Med. 2022 May 20;41(11):1950-1970. doi: 10.1002/sim.9339. Epub 2022 Feb 14.

PMID: 35165917

 

PP2 protects from keratin mutation-associated liver injury and filament disruption via SRC kinase inhibition in male but not female mice.

Li P, Maitra D, Kuo N, Kwan R, Song Y, Tang W, Chen L, Xie Q, Liu L, Omary MB.

Hepatology. 2022 May 19. doi: 10.1002/hep.32574. Online ahead of print.

PMID: 35586977

 

Nivolumab in Esophageal Squamous-Cell Carcinoma. Reply.

Kato K, Lei M.

N Engl J Med. 2022 May 19;386(20):1961. doi: 10.1056/NEJMc2202880.

PMID: 35584169 

 

ACPA-negative and ACPA-positive RA-patients achieving disease resolution demonstrate distinct patterns of MRI-detected joint-inflammation.

Verstappen M, Matthijssen XME, Connolly SE, Maldonado MA, Huizinga TWJ, van der Helm-van Mil AHM.

Rheumatology (Oxford). 2022 May 18:keac294. doi: 10.1093/rheumatology/keac294. Online ahead of print.

PMID: 35583256

 

Building a Healthcare Alliance for Resourceful Medicine Offensive Against Neoplasms in HematologY Added Value Framework for Hematologic Malignancies: A Comparative Analysis of Existing Tools.

Cerisoli F, Ali F, Bereczky T, Bolaños N, Bullinger L, Dhanasiri S, Gallagher J, Pérez SG, Geissler J, Guillevic Y, Harrison K, Naoum A, Portulano C, Rodríguez Vicente AE, Schulze-Rath R, Gómez GY, Sanz G, Hernández Rivas JM.

Value Health. 2022 May 17:S1098-3015(22)01931-3. doi: 10.1016/j.jval.2022.04.1729. Online ahead of print.

PMID: 35595634

 

2021 White Paper on Recent Issues in Bioanalysis: TAb/NAb, Viral Vector CDx, Shedding Assays; CRISPR/Cas9 & CAR-T Immunogenicity; PCR & Vaccine Assay Performance; ADA Assay Comparability & Cut Point Appropriateness (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccine Assays; Immunogenicity of Biotherapeutics and Novel Modalities; Integrated Summary of Immunogenicity Harmonization).

Loo L, Harris S, Milton M, Meena, Lembke W, Berisha F, Bertholet S, Dessy F, Dodge R, Fang X, Fiscella M, Garofolo F, Gorovits B, Gupta S, Jawa V, Ishii-Watabe A, Long B, Lu Y, Mack T, McGuire K, Nolan K, Pan L, Potthoff B, Purushothama S, Smith D, Solstad T, Sonderegger I, Taddeo F, Tangri S, Wagner L, Wu B, Xu Y, Kirshner S, Verthelyi D, Yan H, Maxfield K, Pedras-Vasconcelos J, Abhari MR, Gupta S, Wu Y, Rajadhyaksha M, Andisik M, Baltrukonis D, Cherry E, Cludts I, Gunn G, Millner AH, Jordan G, Kar S, Kubiak R, Lotz GP, Palmer R, Peng K, Poetzl J, Richards S, Savoie N, Staack RF, Stubenrauch K, Wadhwa M, Waxenecker G, Yang TY, Zhang L.

Bioanalysis. 2022 May 17. doi: 10.4155/bio-2022-0081. Online ahead of print.

PMID: 35578991

 

Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data.

Jamieson MJ, Byon W, Dettloff RW, Crawford M, Gargalovic PS, Merali SJ, Onorato J, Quintero AJ, Russ C.

Am J Cardiovasc Drugs. 2022 May 16. doi: 10.1007/s40256-022-00524-x. Online ahead of print.

PMID: 35570249

 

Impact of Axial Spondyloarthritis on Quality of Life: Results From the European Map of Axial Spondyloarthritis (EMAS) Study in France.

Kedra J, Claudepierre P, Flipo RM, Garrido-Cumbrera M, Alliot-Launois F, Desfleurs E, Grange L, Gossec L.

J Rheumatol. 2022 May 15:jrheum.210864. doi: 10.3899/jrheum.210864. Online ahead of print.

PMID: 35569828

 

Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development.

Sangaraju D, Katavolos P, Liang X, Chou C, Zabka TS, Dean B, Maher J.

Toxicol Appl Pharmacol. 2022 May 15;443:116008. doi: 10.1016/j.taap.2022.116008. Epub 2022 Apr 1.

PMID: 35378153

 

Label-free plasma proteomics for the identification of the putative biomarkers of oral squamous cell carcinoma.

Gautam SS, Singh RP, Karsauliya K, Sonker AK, Reddy PJ, Mehrotra D, Gupta S, Singh S, Kumar R, Singh SP.

J Proteomics. 2022 May 15;259:104541. doi: 10.1016/j.jprot.2022.104541. Epub 2022 Feb 26.

PMID: 35231661

 

Synthesis of a dual carbon-14-labeled calcitonin gene-related peptide receptor antagonist for use in a human absorption-distribution-metabolism-elimination study.

Turley WA, Easter JA, Burrell RC, Bonacorsi SJ Jr.

J Labelled Comp Radiopharm. 2022 May 15;65(5):126-139. doi: 10.1002/jlcr.3966. Epub 2022 Mar 10.

PMID: 35199393

 

A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins.

Casalino E, Stine LB, Corin AJ, Thai CT, Quiroz J, Wilson SC, Labow M, Mittal S.

SLAS Discov. 2022 May 14:S2472-5552(22)13673-7. doi: 10.1016/j.slasd.2022.05.001. Online ahead of print.

PMID: 35580766

 

Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance.

Zamek-Gliszczynski MJ, Sangha V, Shen H, Feng B, Wittwer MB, Varma MVS, Liang X, Sugiyama Y, Zhang L, Bendayan R; International Transporter Consortium.

Clin Pharmacol Ther. 2022 May 13. doi: 10.1002/cpt.2644. Online ahead of print.

PMID: 35561119

 

When to Extend Monitoring of Anti-drug Antibodies for High-risk Biotherapeutics in Clinical Trials: an Opinion from the European Immunogenicity Platform.

Lotz GP, Benstein K, Bloem K, Buddiger H, Calonder C, Elm S, Fernandez E, Goodman J, Gorovits B, Grudzinska-Goebel J, Janssen M, Jawa V, Kramer D, Luo L, Malisauskas M, Michaut L, Schäfer M, Spindeldreher S, Ullmann M, Nana Weldingh K, Kromminga A, Snoeck V.

AAPS J. 2022 May 12;24(3):68. doi: 10.1208/s12248-022-00712-2.

PMID: 35554731

 

National Survey on the Effect of Oncology Drug Shortages in Clinical Practice: A Hematology Oncology Pharmacy Association Survey.

McBride A, Hudson-DiSalle S, Pilz J, Hamm M, Boring B, Buie LW, DeRemer DL.

JCO Oncol Pract. 2022 May 11:OP2100883. doi: 10.1200/OP.21.00883. Online ahead of print.

PMID: 35544740

 

Antipsychotic Efficacy of KarXT (Xanomeline-Trospium): Post Hoc Analysis of Positive and Negative Syndrome Scale Categorical Response Rates, Time Course of Response, and Symptom Domains of Response in a Phase 2 Study.

Weiden PJ, Breier A, Kavanagh S, Miller AC, Brannan SK, Paul SM.

J Clin Psychiatry. 2022 May 11;83(3):21m14316. doi: 10.4088/JCP.21m14316.

PMID: 35552528 

 

X-linked genes exhibit miR6891-5p-regulated skewing in Sjögren's syndrome.

Shaw TM, Zhang W, McCoy SS, Pagenkopf A, Carp DM, Garg S, Parker MH, Qiu X, Scofield RH, Galipeau J, Liang Y.

J Mol Med (Berl). 2022 May 10. doi: 10.1007/s00109-022-02205-3. Online ahead of print.

PMID: 35538149

 

Antibody charge variant modulation by in vitro enzymatic treatment in different Chinese hamster ovary cell cultures.

Xu J, Santos J, Anderson NS, Borys MC, Pendse G, Li ZJ.

Biotechnol Prog. 2022 May 10:e3268. doi: 10.1002/btpr.3268. Online ahead of print.

PMID: 35536540

 

Circumventing glass vial and diluent effects on solution stability of small molecule analytes during analytical method development and validation.

Huang Y, Hu Y, Yuill EM, Marriott AS, Chadwick J, Li J, Zang J, Miller SA.

J Pharm Biomed Anal. 2022 May 10;213:114676. doi: 10.1016/j.jpba.2022.114676. Epub 2022 Feb 24.

PMID: 35240407

 

Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.

Parcella K, Wang T, Eastman K, Zhang Z, Yin Z, Patel M, Tu Y, Zheng BZ, Walker MA, Saulnier MG, Frennesson D, Bowsher M, Gillis E, Peese K, Belema M, Cianci C, Dicker IB, McAuliffe B, Ding B, Falk P, Simmermacher J, Parker DD, Sivaprakasam P, Kish K, Lewis H, Hanumegowda U, Jenkins S, Kadow JF, Krystal M, Meanwell NA, Naidu BN.

ACS Med Chem Lett. 2022 May 9;13(6):972-980. doi: 10.1021/acsmedchemlett.2c00115. eCollection 2022 Jun 9.

PMID: 35707159

 

Biomarker Assay Validation by Mass Spectrometry.

Fernández-Metzler C, Ackermann B, Garofolo F, Arnold ME, DeSilva B, Gu H, Laterza O, Mao Y, Rose M, Vazvaei-Smith F, Steenwyk R.

AAPS J. 2022 May 9;24(3):66. doi: 10.1208/s12248-022-00707-z.

PMID: 35534647

 

Development of a LAG-3 immunohistochemistry assay for melanoma.

Johnson L, McCune B, Locke D, Hedvat C, Wojcik JB, Schroyer C, Yan J, Johnson K, Sanders-Cliette A, Samala S, Dillon LM, Anderson S, Shuster J.

J Clin Pathol. 2022 May 9:jclinpath-2022-208254. doi: 10.1136/jclinpath-2022-208254. Online ahead of print.

PMID: 35534200

 

Proton Pump Inhibitor Use and Efficacy of Nivolumab and Ipilimumab in Advanced Melanoma.

Homicsko K, Dummer R, Hoeller C, Wolchok JD, Hodi FS, Larkin J, Ascierto PA, Atkinson V, Robert C, Postow MA, Re S, Paulucci D, Dobler D, Michielin O.

Cancers (Basel). 2022 May 5;14(9):2300. doi: 10.3390/cancers14092300.

PMID: 35565428 

 

Is Incurred Sample Reanalysis (ISR) Applicable in Biomarker Assays?

Hays A, Amaravadi L, Fernandez-Metzler C, King L, Mathews J, Ni Y, Quadrini K, Tinder C, Vazvaei F, Zeng J.

AAPS J. 2022 May 5;24(3):65. doi: 10.1208/s12248-022-00708-y.

PMID: 35511303 

 

Phase 3 Trial of Chemoradiotherapy With Temozolomide Plus Nivolumab or Placebo for Newly Diagnosed Glioblastoma With Methylated MGMT Promoter.

Lim M, Weller M, Idbaih A, Steinbach J, Finocchiaro G, Raval RR, Ansstas G, Baehring J, Taylor JW, Honnorat J, Petrecca K, De Vos F, Wick A, Sumrall A, Sahebjam S, Mellinghoff IK, Kinoshita M, Roberts M, Slepetis R, Warad D, Leung D, Lee M, Reardon DA, Omuro A.

Neuro Oncol. 2022 May 2:noac116. doi: 10.1093/neuonc/noac116. Online ahead of print.

PMID: 35511454

 

CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma.

Wang J, Saung MT, Li K, Fu J, Fujiwara K, Niu N, Muth S, Wang J, Xu Y, Rozich N, Zlomke H, Chen S, Espinoza B, Henderson M, Funes V, Herbst B, Ding D, Twyman-Saint Victor C, Zhao Q, Narang A, He J, Zheng L.

J Exp Med. 2022 May 2;219(5):e20211631. doi: 10.1084/jem.20211631. Epub 2022 Apr 11.

PMID: 35404390 

 

Tim-3 mediates T cell trogocytosis to limit antitumor immunity.

Pagliano O, Morrison RM, Chauvin JM, Banerjee H, Davar D, Ding Q, Tanegashima T, Gao W, Chakka SR, DeBlasio R, Lowin A, Kara K, Ka M, Zidi B, Amin R, Raphael I, Zhang S, Watkins SC, Sander C, Kirkwood JM, Bosenberg M, Anderson AC, Kuchroo VK, Kane LP, Korman AJ, Rajpal A, West SM, Han M, Bee C, Deng X, Schebye XM, Strop P, Zarour HM.

J Clin Invest. 2022 May 2;132(9):e152864. doi: 10.1172/JCI152864.

PMID: 35316223 

 

Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety.

Gao W, Hu H, Dai L, He M, Yuan H, Zhang H, Liao J, Wen B, Li Y, Palmisano M, Traore MDM, Zhou S, Sun D.

Acta Pharm Sin B. 2022 May;12(5):2462-2478. doi: 10.1016/j.apsb.2022.02.015. Epub 2022 Feb 23.

PMID: 35646532 

 

2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).

Kaur S, Alley SC, Szapacs M, Wilson A, Ciccimaro E, Su D, Henderson N, Chen L, Garofolo F, Hengel S, Jian W, Kellie JF, Lee A, Mehl J, Palandra J, Qiu H, Savoie N, Shakleya D, Staelens L, Sugimoto H, Sumner G, Welink J, Wheller R, Xue YJ, Zeng J, Zhang J, Zhou H, Wang J, Summerfield S, Kavetska O, Dillen L, Ramanathan R, Baratta M, Dasgupta A, Edmison A, Ferrari L, Fischer S, Fraier D, Haidar S, Heermeier K, James C, Ji A, Luo L, Lima Santos GM, Post N, Rosenbaum AI, Sporring S, Surapaneni S, Vinter S, Wan K, Woolf E, Kavetska O, Cho SJ, Kossary E, Prior S, Abhari MR, Soo C, Wang YM, Bandukwala A, Cherry E, Cludts I, Ghosh S, Hopper S, Ishii-Watabe A, Kirshner S, Maher K, Maxfield K, Pedras-Vasconcelos J, Saito Y, Smith D, Solstad T, Verthelyi D, Wadhwa M, Wagner L, Waxenecker G, Yan H, Zhang L.

Bioanalysis. 2022 May;14(9):505-580. doi: 10.4155/bio-2022-0078. Epub 2022 May 17.

PMID: 35578993

 

2021 White Paper on Recent Issues in Bioanalysis: ISR for Biomarkers, Liquid Biopsies, Spectral Cytometry, Inhalation/Oral & Multispecific Biotherapeutics, Accuracy/LLOQ for Flow Cytometry (Part 2 - Recommendations on Biomarkers/CDx Assays Development & Validation, Cytometry Validation & Innovation, Biotherapeutics PK LBA Regulated Bioanalysis, Critical Reagents & Positive Controls Generation).

Hersey S, Keller S, Mathews J, King L, Bandukwala A, Berisha F, Birchler M, Bower J, Clausen V, Duarte J, Garofolo F, Hopper S, Kar S, Mabrouk O, Marshall JC, McGuire K, Naughton M, Saito Y, Schuhmann I, Sperinde G, Teixeira P, Vitaliti A, Wang YM, Wnek R, Zhang Y, Spitz S, Decman V, Eck S, Estevam J, Goihberg P, Alcaide EG, Gonneau C, Hedrick MN, Hopkins G, Junker F, Nuti S, Sommer U, Standifer N, Stevens C, Stevens E, Hendricks C, Wadhwa M, Torri A, Ma M, Harris S, Kumar S, Partridge MA, Caiazzo T, Chilewski S, Cludts I, Coble K, Gorovits B, Grimaldi C, Jordan G, Kamerud J, Leary B, Liang M, Lim H, Mayer A, O'Connor E, Palackal N, Poetzl J, Prior S, Abhari MR, Savoie N, Soo C, Ware M, Wu B, Xu Y, Yang TY, Zoghbi J.

Bioanalysis. 2022 May;14(10):627-692. doi: 10.4155/bio-2022-0080. Epub 2022 May 17.

PMID: 35578974

 

The Predictive and Prognostic Nature of Programmed Death-Ligand 1 in Malignant Pleural Mesothelioma: A Systematic Literature Review.

Mansfield AS, Brown RJ, Sammon C, Daumont MJ, McKenna M, Sanzari JK, Forde PM.\

TO Clin Res Rep. 2022 Mar 22;3(5):100315. doi: 10.1016/j.jtocrr.2022.100315. eCollection 2022 May.

PMID: 35516726

 

Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.

Oliveira G, Stromhaug K, Cieri N, Iorgulescu JB, Klaeger S, Wolff JO, Rachimi S, Chea V, Krause K, Freeman SS, Zhang W, Li S, Braun DA, Neuberg D, Carr SA, Livak KJ, Frederick DT, Fritsch EF, Wind-Rotolo M, Hacohen N, Sade-Feldman M, Yoon CH, Keskin DB, Ott PA, Rodig SJ, Boland GM, Wu CJ.

Nature. 2022 May;605(7910):532-538. doi: 10.1038/s41586-022-04682-5. Epub 2022 May 4.

PMID: 35508657

 

Private Spaceflight: A New Landscape for Dealing with Medical Risk.

Griko YV, Loftus DJ, Stolc V, Peletskaya E.

Life Sci Space Res (Amst). 2022 May;33:41-47. doi: 10.1016/j.lssr.2022.03.001. Epub 2022 Mar 23.

PMID: 35491028

 

First-line nivolumab plus ipilimumab versus chemotherapy for the treatment of unresectable malignant pleural mesothelioma: patient-reported outcomes in CheckMate 743.

Scherpereel A, Antonia S, Bautista Y, Grossi F, Kowalski D, Zalcman G, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Sun X, Lawrance R, Zhang X, Daumont MJ, Bennett B, McKenna M, Baas P.

Lung Cancer. 2022 May;167:8-16. doi: 10.1016/j.lungcan.2022.03.012. Epub 2022 Mar 21.

PMID: 35367910 

 

A global perspective in second-line treatment patterns for patients with advanced esophageal squamous cell carcinoma.

Jaffe DH, Gricar J, DeCongelio M, Mackie DS.

Thorac Cancer. 2022 May;13(9):1240-1257. doi: 10.1111/1759-7714.14334. Epub 2022 Mar 30.

PMID: 35355433 

 

Luspatercept for myelodysplastic syndromes/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis.

Komrokji RS, Platzbecker U, Fenaux P, Zeidan AM, Garcia-Manero G, Mufti GJ, Santini V, Díez-Campelo M, Finelli C, Jurcic JG, Greenberg PL, Sekeres MA, DeZern AE, Savona MR, Shetty JK, Ito R, Zhang G, Ha X, Backstrom JT, Verma A.

Leukemia. 2022 May;36(5):1432-1435. doi: 10.1038/s41375-022-01521-4. Epub 2022 Feb 26.

PMID: 35220402  

 

Health State Utilities for Adverse Events Associated with Chimeric Antigen Receptor T-Cell Therapy in Large B-Cell Lymphoma.

Howell TA, Matza LS, Jun MP, Garcia J, Powers A, Maloney DG.

Pharmacoecon Open. 2022 May;6(3):367-376. doi: 10.1007/s41669-021-00316-0. Epub 2022 Feb 7.

PMID: 35129829 

 

First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743.

Peters S, Scherpereel A, Cornelissen R, Oulkhouir Y, Greillier L, Kaplan MA, Talbot T, Monnet I, Hiret S, Baas P, Nowak AK, Fujimoto N, Tsao AS, Mansfield AS, Popat S, Zhang X, Hu N, Balli D, Spires T, Zalcman G.

Ann Oncol. 2022 May;33(5):488-499. doi: 10.1016/j.annonc.2022.01.074. Epub 2022 Feb 3.

PMID: 35124183 

 

Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8).

Sreekantha RK, Mussari CP, Dodd DS, Pasunoori L, Hegde S, Posy SL, Critton D, Ruepp S, Subramanian M, Salter-Cid LM, Tagore DM, Sarodaya S, Dudhgaonkar S, Poss MA, Schieven GL, Carter PH, Macor JE, Dyckman AJ.

ACS Med Chem Lett. 2022 Apr 25;13(5):812-818. doi: 10.1021/acsmedchemlett.2c00049. eCollection 2022 May 12.

PMID: 35586440

 

A State-of-the-Art Roadmap for Biomarker-Driven Drug Development in the Era of Personalized Therapies.

Serelli-Lee V, Ito K, Koibuchi A, Tanigawa T, Ueno T, Matsushima N, Imai Y.

J Pers Med. 2022 Apr 21;12(5):669. doi: 10.3390/jpm12050669.

PMID: 35629092 

 

Development of an enhanced formulation to minimize pharmacokinetic variabilities of a weakly basic drug compound.

Pu YE, Menger R, Tong Z, Gaebele T.

Pharm Dev Technol. 2022 Apr;27(4):406-413. doi: 10.1080/10837450.2022.2070206. Epub 2022 May 11.

PMID: 35502986

 

Long-term Outcomes with Nivolumab as First-line Treatment in Recurrent or Metastatic Head and Neck Cancer: Subgroup Analysis of CheckMate 141.

Gillison ML, Blumenschein G, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington KJ, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Jayaprakash V, Wei L, Ferris RL.

Oncologist. 2022 Mar 4;27(2):e194-e198. doi: 10.1093/oncolo/oyab036.

PMID: 35641218 

 

Phase Ib study of avadomide (CC-122) in combination with rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma.

Nastoupil LJ, Kuruvilla J, Chavez JC, Bijou F, Witzig TE, Santoro A, Flinn IW, Boccomini C, Kenkre VP, Corradini P, Isufi I, Andorsky DJ, Klein LM, Greenwald DR, Sangha R, Shen F, Hagner P, Li Y, Dobmeyer J, Gong N, Uttamsingh S, Pourdehnad M, Ribrag V.

EJHaem. 2022 Feb 14;3(2):394-405. doi: 10.1002/jha2.394. eCollection 2022 May.

PMID: 35846031 

 

Phase Ib study of combinations of avadomide (CC-122), CC-223, CC-292, and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma.

Ribrag V, Chavez JC, Boccomini C, Kaplan J, Chandler JC, Santoro A, Corradini P, Flinn IW, Advani R, Cassier PA, Sangha R, Kenkre VP, Isufi I, Uttamsingh S, Hagner PR, Gandhi AK, Shen F, Michelliza S, Haeske H, Hege K, Pourdehnad M, Kuruvilla J.

EJHaem. 2022 Jan 14;3(1):139-153. doi: 10.1002/jha2.375. eCollection 2022 Feb.

PMID: 35846221 

 

Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England.

Hill NR, Groves L, Dickerson C, Boyce R, Lawton S, Hurst M, Pollock KG, Sugrue DM, Lister S, Arden C, Davies DW, Martin AC, Sandler B, Gordon J, Farooqui U, Clifton D, Mallen C, Rogers J, Camm AJ, Cohen AT.

J Med Econ. 2022 Jan-Dec;25(1):974-983. doi: 10.1080/13696998.2022.2102355.

PMID: 35834373

 

The impact of remission duration on the long-term economic burden of acute myeloid leukemia among patients without hematopoietic stem cell transplant in the United States.

Tabah A, Brady BL, Huggar D, Jariwala-Parikh K, Huey K, Copher R, LeBlanc TW.

J Med Econ. 2022 Jan-Dec;25(1):903-911. doi: 10.1080/13696998.2022.2091879.

PMID: 35723576

 

Cost-effectiveness analysis of nivolumab plus ipilimumab versus platinum-doublet chemotherapy for first-line treatment of stage IV or recurrent non-small cell lung cancer in the United States.

Berling M, Chaudhary MA, Yuan Y, Varol N, Dale P, Testa E, Klint J, Lee A, Lubinga SJ, Penrod JR.

J Med Econ. 2022 Jan-Dec;25(1):703-711. doi: 10.1080/13696998.2022.2077549.

PMID: 35659172

 

Cost-effectiveness analysis of nivolumab plus ipilimumab plus two cycles of platinum-doublet chemotherapy versus platinum-doublet chemotherapy alone for first-line treatment of stage IV or recurrent non-small cell lung cancer in the United States.

Polyzoi M, Sandhu H, Maervoet J, Yuan Y, Chaudhary MA, Varol N, Lee A, Dale P, Jones C, Lubinga SJ, Penrod JR.

J Med Econ. 2022 Jan-Dec;25(1):660-668. doi: 10.1080/13696998.2022.2048573.

PMID: 35658806

 

Response to "Critical Analysis of Apixaban Dose Adjustment Criteria".

Mandt SR, Gaitonde P, Ajavon-Hartmann A, Klem C, Chan A, Bastien A.

Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221078841. doi: 10.1177/10760296221078841.

PMID: 35603638  

 

Long-term hospital resource utilization and associated costs of care for patients initiating nivolumab in advanced non-small cell lung cancer in France.

Grumberg V, Chouaïd C, Cotté FE, Jouaneton B, Jolivel R, Gaudin AF, Reynaud D, Assié JB, Borget I.

J Med Econ. 2022 Jan-Dec;25(1):691-699. doi: 10.1080/13696998.2022.2079291.

PMID: 35587018

 

Optimization of Recombinant GPCR Proteins for Biophysical and Structural Studies Using Virus-like Particles.

Aertgeerts K, Ho TT, Yan YG.

Methods Mol Biol. 2022;2507:327-336. doi: 10.1007/978-1-0716-2368-8_17.

PMID: 35773590

 

Thrombotic and bleeding events, mortality, and anticoagulant use among 546,656 hospitalized patients with COVID-19 in the United States: a retrospective cohort study. 

Deitelzweig S, Luo X, Nguyen JL, Malhotra D, Emir B, Russ C, Li X, Lee TC, Ferri M, Wiederkehr D, Reimbaeva M, Barnes GD, Piazza G.

J Thromb Thrombolysis. 2022 Apr 30:1-11. doi: 10.1007/s11239-022-02644-2. Online ahead of print. 

PMID: 35489004 

 

Indirect treatment comparison of idecabtagene vicleucel versus conventional care in triple-class exposed multiple myeloma. 

Shah N, Mojebi A, Ayers D, Cope S, Dhanasiri S, Davies FE, Hari P, Patel P, Hege K, Dhanda D. 

J Comp Eff Res. 2022 Apr 29. doi: 10.2217/cer-2022-0045. Online ahead of print. 

PMID: 35485211 

 

A Nitrite Excipient Database: A Useful Tool to Support N-Nitrosamine Risk Assessments for Drug Products. 

Boetzel R, Schlingemann J, Hickert S, Korn C, Kocks G, Luck B, Blom G, Harrison M, François M, Allain L, Wu Y, Bousraf Y. 

J Pharm Sci. 2022 Apr 29:S0022-3549(22)00168-X. doi: 10.1016/j.xphs.2022.04.016. Online ahead of print. 

PMID: 35500671 

 

Direct comparison of circulating tumor DNA sequencing assays with targeted large gene panels. 

Yu L, Lopez G, Rassa J, Wang Y, Basavanhally T, Browne A, Huang CP, Dorsey L, Jen J, Hersey S. 

PLoS One. 2022 Apr 28;17(4):e0266889. doi: 10.1371/journal.pone.0266889. eCollection 2022. 

PMID: 35482763 

 

Biological impact of iberdomide in patients with active systemic lupus erythematosus. 

Lipsky PE, Vollenhoven RV, Dörner T, Werth VP, Merrill JT, Furie R, Petronijevic M, Velasco Zamora B, Majdan M, Irazoque-Palazuelos F, Terbrueggen R, Delev N, Weiswasser M, Korish S, Stern M, Hersey S, Ye Y, Gaudy A, Liu Z, Gagnon R, Tang S, Schafer PH. 

Ann Rheum Dis. 2022 Apr 27:annrheumdis-2022-222212. doi: 10.1136/annrheumdis-2022-222212. Online ahead of print. 

PMID: 35477518 

 

Safety and efficacy of fedratinib, a selective oral inhibitor of Janus kinase-2 (JAK2), in patients with myelofibrosis and low pretreatment platelet counts. 

Harrison CN, Schaap N, Vannucchi AM, Kiladjian JJ, Passamonti F, Zweegman S, Talpaz M, Verstovsek S, Rose S, Zhang J, Sy O, Mesa RA. 

Br J Haematol. 2022 Apr 27. doi: 10.1111/bjh.18207. Online ahead of print. 

PMID: 35476316 

 

Assessment of Resonant Acoustic Mixing for Low-Dose Pharmaceutical Powder Blends. 

Gupta S, Pu YE, Li M, Li Z, Osorio JG. 

AAPS PharmSciTech. 2022 Apr 26;23(5):126. doi: 10.1208/s12249-022-02262-4. 

PMID: 35474151 

 

ReducinG stroke by screening for UndiAgnosed atRial fibrillation in elderly inDividuals (GUARD-AF): Rationale and Design of the GUARD-AF Randomized Trial of Screening for Atrial Fibrillation with a 14-day Patch-Based Continuous ECG Monitor. 

Singer DE, Atlas SJ, Go AS, Lopes RD, Lubitz SA, McManus DD, Revkin JH, Mills D, Crosson LA, Lenane JC, Aronson RS. 

Am Heart J. 2022 Apr 23:S0002-8703(22)00080-1. doi: 10.1016/j.ahj.2022.04.005. Online ahead of print. 

PMID: 35472303 

 

5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction. 

Nakao K, Singh M, Sapkota K, Fitzgerald A, Hablitz JJ, Nakazawa K. 

Transl Psychiatry. 2022 Apr 22;12(1):168. doi: 10.1038/s41398-022-01930-0. 

PMID: 35459266 

 

Next generation automated traceless cell chromatography platform for GMP-compliant cell isolation and activation. 

Radisch S, Poltorak MP, Wagner M, Cletiu V, Radisch C, Treise I, Pann S, Weigt A, Artner S, Dreher S, Fechner F, Borjan B, Fraessle SP, Effenberger M, Benke E, Navratil G, Hentschel N, Busch DH, Schmidt T, Stemberger C, Germeroth L. 

Sci Rep. 2022 Apr 21;12(1):6572. doi: 10.1038/s41598-022-10320-x. 

PMID: 35449227 

 

Impact of Drug Conjugation on Thermal and Metabolic Stabilities of Aglycosylated and N-Glycosylated Antibodies. 

Yamazoe S, Kotapati S, Hogan JM, West SM, Deng XA, Diong SJ, Arbanas J, Nguyen TA, Jashnani A, Gupta D, Rajpal A, Dollinger G, Strop P. 

Bioconjug Chem. 2022 Apr 20;33(4):576-585. doi: 10.1021/acs.bioconjchem.1c00572. Epub 2022 Mar 28. 

PMID: 35344340 

 

Building consensus on author selection practices for industry-sponsored research: recommendations from an expert task force of medical publication professionals. 

Carfagno ML, Schweers SA, Whann EA, Hodgson MB, Mittleman KD, Nastasee SA, Sorgenfrei T, Kodukulla MI; International Society for Medical Publication Professionals Authorship Task Force. 

Curr Med Res Opin. 2022 Apr 19:1-8. doi: 10.1080/03007995.2022.2050111. Online ahead of print. 

PMID: 35437066 

 

The Impact of Mavacamten on the Pathophysiology of Hypertrophic Cardiomyopathy: A Narrative Review. 

Edelberg JM, Sehnert AJ, Mealiffe ME, Del Rio CL, McDowell R. 

Am J Cardiovasc Drugs. 2022 Apr 18. doi: 10.1007/s40256-022-00532-x. Online ahead of print. 

PMID: 35435607 

 

Analysis of a Real-World Progression Variable and Related Endpoints for Patients with Five Different Cancer Types. 

Torres AZ, Nussbaum NC, Parrinello CM, Bourla AB, Bowser BE, Wagner S, Tabano DC, George D, Miksad RA. 

Adv Ther. 2022 Apr 17. doi: 10.1007/s12325-022-02091-8. Online ahead of print. 

PMID: 35430670 

 

Pomalidomide, dexamethasone, and daratumumab in Japanese patients with relapsed or refractory multiple myeloma after lenalidomide-based treatment. 

Matsue K, Sunami K, Matsumoto M, Kuroda J, Sugiura I, Iwasaki H, Chung W, Kuwayama S, Nishio M, Lee K, Iida S. 

Int J Hematol. 2022 Apr 16. doi: 10.1007/s12185-022-03338-4. Online ahead of print. 

PMID: 35429329 

 

Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning. 

He Q, Rehmann MS, Tian J, Xu J, Sabino L, Vandermark E, Basson Z, Po I, Bierilo K, Tremml G, Rizzi G, Langsdorf EF, Qian NX, Borys MC, Khetan A, Li ZJ. 

Bioengineering (Basel). 2022 Apr 15;9(4):173. doi: 10.3390/bioengineering9040173. 

PMID: 35447733 

 

Secukinumab in US Biologic-Naive Patients With Psoriatic Arthritis: Results From the Randomized, Placebo-Controlled CHOICE Study. 

Nguyen T, Churchill M, Levin R, Valenzuela G, Merola JF, Ogdie A, Orbai AM, Scher JU, Kavanaugh A, Kianifard F, Rollins C, Calheiros R, Chambenoit O. 

J Rheumatol. 2022 Apr 15:jrheum.210912. doi: 10.3899/jrheum.210912. Online ahead of print. 

PMID: 35428722 

 

Baseline Disease Activity Predicts Achievement of cDAPSA Treatment Targets With Apremilast: Phase 3 Results in DMARD-Naive Patients With Psoriatic Arthritis. 

Mease PJ, Kavanaugh A, Ogdie A, Wells AF, Bergman M, Gladman DD, Richter S, Teng L, Jardon S, Smolen JS. 

J Rheumatol. 2022 Apr 15:jrheum.210906. doi: 10.3899/jrheum.210906. Online ahead of print. 

PMID: 35428720 

 

Potential Impact of Sex and Body Mass Index on Response to Therapy in Psoriatic Arthritis: Post-hoc Analysis of Results From the SEAM-PsA Trial. 

Mease PJ, Gladman DD, Merola JF, Deodhar A, Ogdie A, Collier DH, Liu L, Kavanaugh A. 

J Rheumatol. 2022 Apr 15:jrheum.211037. doi: 10.3899/jrheum.211037. Online ahead of print. 

PMID: 35428718 

 

Effectiveness of 6-Month Use of Secukinumab in Patients With Psoriatic Arthritis in the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry. 

Mease PJ, Blachley T, Dube B, McLean RR, Kim N, Hur P, Ogdie A. 

J Rheumatol. 2022 Apr 15:jrheum.211033. doi: 10.3899/jrheum.211033. Online ahead of print. 

PMID: 35428716 

 

Challenges in the Diagnosis and Assessment of Psoriatic Arthritis. 

Ogdie A, Lindsay CA, Mease PJ, Callis Duffin K, Rosen CF, Siebert S. 

J Rheumatol. 2022 Apr 15:jrheum.211337. doi: 10.3899/jrheum.211337. Online ahead of print. 

PMID: 35428713 

 

2021 GRAPPA Meet the Experts Session: A Summary of Presentations. 

Armstrong AW, Reddy RM, FitzGerald O, Callis Duffin K, Helliwell PS, Mease PJ, Kavanaugh A, Merola JF, Tillet W, de Wit M.

J Rheumatol. 2022 Apr 15:jrheum.211326. doi: 10.3899/jrheum.211326. Online ahead of print. 

PMID: 35428707 

 

Improving the performance of Bayesian logistic regression model with overdose control in oncology dose-finding studies. 

Zhang H, Chiang AY, Wang J. 

Stat Med. 2022 Apr 15. doi: 10.1002/sim.9402. Online ahead of print. 

PMID: 35428037 

 

Thrombotic and Cardiovascular Events and Treatment Patterns Among Patients Hospitalized with COVID-19 in Japan: An Analysis of a Nationwide Medical Claims Database. 

Terasaka N, Matsuo Y, Kataoka H, Miyata Y, Anazawa Y. 

Cardiol Ther. 2022 Apr 15:1-12. doi: 10.1007/s40119-022-00263-9. Online ahead of print. 

PMID: 35426621 

 

Evaluation of chiral normal-phase liquid chromatography as a secondary tier in pharmaceutical chiral screening strategy. 

Tai HC, Lin Z, Fabiano A, Zhou Y, Saurer EM, Ye YK, He BL.

J Chromatogr A. 2022 Apr 14;1672:463053. doi: 10.1016/j.chroma.2022.463053. 

PMID: 35460990 

 

Radiotherapy Combined With Nivolumab or Temozolomide for Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter: An International Randomized Phase 3 Trial. 

Omuro A, Brandes AA, Carpentier AF, Idbaih A, Reardon DA, Cloughesy T, Sumrall A, Baehring J, van den Bent M, Bähr O, Lombardi G, Mulholland P, Tabatabai G, Lassen U, Sepulveda JM, Khasraw M, Vauleon E, Muragaki Y, Di Giacomo AM, Butowski N, Roth P, Qian X, Fu AZ, Liu Y, Potter V, Chalamandaris AG, Tatsuoka K, Lim M, Weller M. 

Neuro Oncol. 2022 Apr 14:noac099. doi: 10.1093/neuonc/noac099. Online ahead of print. 

PMID: 35419607 

 

Identification of poor prognostic joint locations in an early rheumatoid arthritis cohort at risk of rapidly progressing disease: a post-hoc analysis of the Phase III AGREE study. 

Durez P, Westhovens R, Baeke F, Elbez Y, Robert S, Ahmad HA. 

BMC Rheumatol. 2022 Apr 14;6(1):24. doi: 10.1186/s41927-022-00252-4. 

PMID: 35418172 

 

Report of the First International Symposium on NUT Carcinoma. 

French CA, Cheng ML, Hanna GJ, DuBois SG, Chau NG, Hann CL, Storck S, Salgia R, Trucco M, Tseng J, Stathis A, Piekarz R, Lauer UM, Massard C, Bennett K, Coker S, Tontsch-Grunt U, Sos ML, Liao S, Wu CJ, Polyak K, Piha-Paul SA, Shapiro GI. 

Clin Cancer Res. 2022 Apr 13:clincanres.0591.2022. doi: 10.1158/1078-0432.CCR-22-0591. Online ahead of print. 

PMID: 35417004 

 

2-Pyridine Carboxaldehyde for Semi-Automated Soft Spot Identification in Cyclic Peptides. 

Zhang H, Chacko S, Cannon JR. 

Int J Mol Sci. 2022 Apr 12;23(8):4269. doi: 10.3390/ijms23084269. 

PMID: 35457087 

 

Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer. 

Forde PM, Spicer J, Lu S, Provencio M, Mitsudomi T, Awad MM, Felip E, Broderick SR, Brahmer JR, Swanson SJ, Kerr K, Wang C, Ciuleanu TE, Saylors GB, Tanaka F, Ito H, Chen KN, Liberman M, Vokes EE, Taube JM, Dorange C, Cai J, Fiore J, Jarkowski A, Balli D, Sausen M, Pandya D, Calvet CY, Girard N; CheckMate 816 Investigators. 

N Engl J Med. 2022 Apr 11. doi: 10.1056/NEJMoa2202170. Online ahead of print. 

PMID: 35403841 

 

A vision for integrated publicly available information on regulated medical products. 

Roberts K, Thakkar R, Aljuburi L, Boyce D, Curtis S, Dudinak J, Fitton H, Garner C, Garvin M, Longman S, Reilly E, Maitland J, Reisin Miller A, Pasté M, Rohrer M, Taisey M, Van Baelen K, Wegner M. 

Clin Transl Sci. 2022 Apr 9. doi: 10.1111/cts.13275. Online ahead of print. 

PMID: 35397194 

 

Influence of Concomitant Methotrexate use on the Clinical Effectiveness, Retention, and Safety of Abatacept in Biologic-Naïve Patients with Rheumatoid Arthritis: Post-hoc Subgroup Analysis of ORIGAMI Study. 

Azuma T, Misaki K, Kusaoi M, Suzuki Y, Higa S, Kumon Y, Yoshitama T, Naniwa T, Yamada S, Okano T, Takeuchi K, Ikeda K, Higami K, Inoo M, Sawada T, Kang C, Hayashi M, Nagaya Y, Hagiwara T, Shono E, Himeno S, Tanaka E, Inoue E, Yoshizawa Y, Kadode M, Yamanaka H, Harigai M. 

Mod Rheumatol. 2022 Apr 7:roac032. doi: 10.1093/mr/roac032. Online ahead of print. 

PMID: 35389481 

 

Advances in mass spectrometry-based epitope mapping of protein therapeutics. 

Liu XR, Huang RY, Zhao F, Chen G, Tao L. 

J Pharm Biomed Anal. 2022 Apr 6;215:114754. doi: 10.1016/j.jpba.2022.114754. Online ahead of print. 

PMID: 35427962 

 

Conditional survival and long-term efficacy with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma. 

Motzer RJ, McDermott DF, Escudier B, Burotto M, Choueiri TK, Hammers HJ, Barthélémy P, Plimack ER, Porta C, George S, Powles T, Donskov F, Gurney H, Kollmannsberger CK, Grimm MO, Barrios C, Tomita Y, Castellano D, Grünwald V, Rini BI, McHenry MB, Lee CW, McCarthy J, Ejzykowicz F, Tannir NM. 

Cancer. 2022 Apr 5. doi: 10.1002/cncr.34180. Online ahead of print. 

PMID: 35383908 

 

Ni-Electrocatalytic C(sp³)-C(sp³) Doubly Decarboxylative Coupling. 

Zhang B, Gao Y, Hioki Y, Oderinde MS, Qiao JX, Rodriguez KX, Zhang HJ, Kawamata Y, Baran PS. Nature. 2022 Apr 5. doi: 10.1038/s41586-022-04691-4. Online ahead of print. 

PMID: 35381598 

 

The benefits, limitations and opportunities of preclinical models for neonatal drug development. 

Campion S, Inselman A, Hayes B, Casiraghi C, Joseph D, Facchinetti F, Salomone F, Schmitt G, Hui J, Davis-Bruno K, Van Malderen K, Morford L, De Schaepdrijver L, Wiesner L, Kourula S, Seo S, Laffan S, Urmaliya V, Chen C. 

Dis Model Mech. 2022 Apr 1;15(4):dmm049065. doi: 10.1242/dmm.049065. Epub 2022 Apr 25. 

PMID: 35466995 

 

Assessment of hyperprogression versus the natural course of disease development with nivolumab with or without ipilimumab versus placebo in phase III, randomized, controlled trials. 

Kang YK, Reck M, Nghiem P, Feng Y, Plautz G, Kim HR, Owonikoko TK, Boku N, Chen LT, Lei M, Chang H, Lin WH, Roy A, Bello A, Sheng J. 

J Immunother Cancer. 2022 Apr;10(4):e004273. doi: 10.1136/jitc-2021-004273.

PMID: 35383114 

 

Basic Science Session 1. Biomarkers for Psoriatic Arthritis Treatment Response and Joint Damage Progression: An Update on 2 Industry-GRAPPA Projects. 

Waddington JC, Coleman O, Mease PJ, Chandran V, O'Sullivan D, FitzGerald O, Pennington SR. 

J Rheumatol. 2022 Apr 1:jrheum.211320. doi: 10.3899/jrheum.211320. Online ahead of print. 

PMID: 35365582 

 

Proceedings of the 2021 GRAPPA-Collaborative Research Network (CRN) Meeting. 

Stober C, McInnes IB, Raychaudhuri S, Mease PJ, Pennington SR, Scher JU, Chandran V, Armstrong AW, de Wit M, Cauli A, Jadon DR, Löve TJ, Ogdie A, O'Sullivan D, van Mens LJJ, Ritchlin CT, FitzGerald O. 

J Rheumatol. 2022 Apr 1:jrheum.211336. doi: 10.3899/jrheum.211336. Online ahead of print. 

PMID: 35365578 

 

Hallmarks of Resistance to Immune-Checkpoint Inhibitors. 

Karasarides M, Cogdill AP, Robbins PB, Bowden M, Burton EM, Butterfield LH, Cesano A, Hammer C, Haymaker CL, Horak CE, McGee HM, Monette A, Rudqvist NP, Spencer CN, Sweis RF, Vincent BG, Wennerberg E, Yuan J, Zappasodi R, Lucey VMH, Wells DK, LaVallee T. 

Cancer Immunol Res. 2022 Apr 1;10(4):372-383. doi: 10.1158/2326-6066.CIR-20-0586. 

PMID: 35362046 

 

Meningococcal Vaccination Rates Among People With a New Diagnosis of HIV Infection in the US. 

Ghaswalla PK, Marshall GS, Bengtson LGS, Buikema AR, Bancroft T, Koep E, Novy P, Hogea CS. 

JAMA Netw Open. 2022 Apr 1;5(4):e228573. doi: 10.1001/jamanetworkopen.2022.8573. 

PMID: 35486405

 

Real-world effectiveness of immunotherapies in pre-treated, advanced non-small cell lung cancer Patients: A systematic literature review. 

Juarez-Garcia A, Sharma R, Hunger M, Kayaniyil S, Penrod JR, Chouaïd C. 

Lung Cancer. 2022 Apr;166:205-220. doi: 10.1016/j.lungcan.2022.03.008. Epub 2022 Mar 9. 

PMID: 35316754 

 

RP-HPLC separation of interconvertible rotamers of a 5-tetrahydroisoquinolin-6-yl-pyridin-3-yl acetic acid derivative and confirmation by VT NMR and DFT study. 

Chauthe SK, Sidduri P, Reddy M, Sistla R, Byri V, Uttaravalli MD, Botlagunta M, Kumar H, Gupta A, Gupta AK, Bajpai L, Bagadi M, Mathur A. 

J Pharm Biomed Anal. 2022 Apr 1;212:114675. doi: 10.1016/j.jpba.2022.114675. Epub 2022 Feb 17. 

PMID: 35192992 

 

Synthesis of carbon-14 and stable isotope labeled Censavudine. 

Burrell RC, Bonacorsi SJ Jr, Ortiz A, Benkovics T, Shi Z. 

J Labelled Comp Radiopharm. 2022 Apr;65(4):112-122. doi: 10.1002/jlcr.3964. Epub 2022 Feb 10. 

PMID: 35106813 

 

Pharmacokinetics of Temsavir, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir, Coadministered with Cobicistat, Etravirine, Darunavir/Cobicistat, or Darunavir/Ritonavir with or without Etravirine in Healthy Participants. 

Moore K, Thakkar N, Magee M, Sevinsky H, Vakkalagadda B, Lubin S, Llamoso C, Ackerman P. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0225121. doi: 10.1128/aac.02251-21. Epub 2022 Mar 22. 

PMID: 35315687 

 

Real-world clinical outcomes of patients with myelofibrosis treated with ruxolitinib: a medical record review. 

Passamonti F, Heidel FH, Parikh RC, Ajmera M, Tang D, Nadal JA, Davis KL, Abraham P. 

Future Oncol. 2022 Apr 7. doi: 10.2217/fon-2021-1358. Online ahead of print. 

PMID: 35388710 

 

Hypothetical Generalized Framework for a New Imaging Endpoint of Therapeutic Activity in Early Phase Clinical Trials in Brain Tumors. 

Ellingson BM, Gerstner ER, Lassman AB, Chung C, Colman H, Cole PE, Leung D, Allen JE, Ahluwalia MS, Boxerman J, Brown M, Goldin J, Nduom E, Hassan I, Gilbert MR, Mellinghoff IK, Weller M, Chang S, Arons D, Meehan C, Selig W, Tanner K, Yung WKA, van den Bent M, Wen PY, Cloughesy TF. 

Neuro Oncol. 2022 Apr 5:noac086. doi: 10.1093/neuonc/noac086. Online ahead of print. 

PMID: 35380705 

 

The Association of Illness-Related Uncertainty with Mental Health in Systemic Autoimmune Rheumatic Diseases. 

Wallace ZS, Cook C, Finkelstein-Fox L, Fu X, Castelino FV, Choi HK, Perugino C, Stone JH, Park ER, Hall DL.

J Rheumatol. 2022 Apr 1:jrheum.211084. doi: 10.3899/jrheum.211084. Online ahead of print. 

PMID: 35365580 

 

Real-world evidence comparing oral anticoagulants in non-valvular atrial fibrillation: a systematic review and network meta-analysis. 

Deitelzweig S, Bergrath E, di Fusco M, Kang A, Savone M, Cappelleri JC, Russ C, Betts M, Cichewicz A, Schaible K, Tarpey J, Fahrbach K. 

Future Cardiol. 2022 Apr 1. doi: 10.2217/fca-2021-0120. Online ahead of print. 

PMID: 35360925 

 

Kick-off meeting of the TOWWERS showcase project: 1^st collaborative value-based healthcare anchored on real-world data involving the 5P. 

Frappier J, Krelenbaum M, Villalba E, Martin P, Nour N, L'Espérance J, Perrault A, Decelle B, Larose AM, Viau V, Fahey R, Denault JF, Fauchon I, Huard M, Frappier M. 

Expert Rev Pharmacoecon Outcomes Res. 2022 Apr 1:1-5. doi: 10.1080/14737167.2022.2055549. Online ahead of print. 

PMID: 35312399 

 

Orchestrating a β-Hydride Elimination Pathway in Palladium(II)-Catalyzed Arylation/Alkenylation of Cyclopropanols Using Organoboron Reagents. 

Ramar T, Subbaiah MAM, Ilangovan A.

J Org Chem. 2022 Apr 1;87(7):4508-4523. doi: 10.1021/acs.joc.1c02735. Epub 2022 Mar 15. 

PMID: 35289619 

 

Analyzing longitudinal binary data in clinical studies. 

Li Y, Feng D, Sui Y, Li H, Song Y, Zhan T, Cicconetti G, Jin M, Wang H, Chan I, Wang X. 

Contemp Clin Trials. 2022 Apr;115:106717. doi: 10.1016/j.cct.2022.106717. Epub 2022 Feb 28. 

PMID: 35240309 

 

Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3-selective GABAkine KRM-II-81. 

Golani LK, Divović B, Sharmin D, Pandey KP, Mian MY, Cerne R, Zahn NM, Meyer MJ, Tiruveedhula VVNPB, Smith JL, Ping X, Jin X, Lippa A, Schkeryantz JM, Arnold LA, Cook JM, Savić MM, Witkin JM. Biopharm Drug Dispos. 2022 Apr;43(2):66-75. doi: 10.1002/bdd.2313. Epub 2022 Mar 10. 

PMID: 35194800 

 

First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in advanced non-small cell lung cancer: a subanalysis of Asian patients in CheckMate 9LA. 

John T, Sakai H, Ikeda S, Cheng Y, Kasahara K, Sato Y, Nakahara Y, Takeda M, Kaneda H, Zhang H, Maemondo M, Minato K, Hisada T, Misumi Y, Satouchi M, Hotta K, Li A, Oukessou A, Lu S. 

Int J Clin Oncol. 2022 Apr;27(4):695-706. doi: 10.1007/s10147-022-02120-0. Epub 2022 Feb 19. 

PMID: 35182247 

 

Lack of Electrocardiographic Effects of Deucravacitinib in Healthy Subjects. 

Chimalakonda A, Singhal S, Darbenzio R, Dockens R, Marchisin D, Banerjee S, Girgis IG, Throup J, He B, Aras U, Murthy B. 

Clin Pharmacol Drug Dev. 2022 Apr;11(4):442-453. doi: 10.1002/cpdd.1056. Epub 2022 Feb 19. 

PMID: 35182043 

 

The Role of Shared Epitope in Rheumatoid Arthritis Prognosis in Relation to Anti-Citrullinated Protein Antibody Positivity. 

Zhuo J, Xia Q, Sharma N, Gao S, Lama S, Cui J, Feathers V, Shadick N, Weinblatt ME. 

Rheumatol Ther. 2022 Apr;9(2):637-647. doi: 10.1007/s40744-022-00427-y. Epub 2022 Feb 16. 

PMID: 35174462 

 

Use of In Vitro Human Skin Models to Assess Potential Immune Activation In Response to Biotherapeutic Attributes and Process-related Impurities. 

Tokuda JM, Xie J, Jawa V, Hawkins JM, Ferbas J, Joh NH, Joubert MK. 

J Pharm Sci. 2022 Apr;111(4):1012-1023. doi: 10.1016/j.xphs.2022.02.001. Epub 2022 Feb 6. 

PMID: 35139332 

 

Financial toxicity and its impact on health outcomes and caregiver burden among adult cancer survivors in the USA. 

Inguva S, Priyadarshini M, Shah R, Bhattacharya K. 

Future Oncol. 2022 Apr;18(13):1569-1581. doi: 10.2217/fon-2021-1282. Epub 2022 Feb 7. 

PMID: 35129377 

 

Treatment patterns and outcomes following disease progression on anti-PD-1 therapies for advanced melanoma. 

Nordstrom BL, Hamilton M, Collins JM, Earle D, Zhang Y, Srivastava S, Hernandez-Aya L. 

Future Oncol. 2022 Apr;18(11):1343-1355. doi: 10.2217/fon-2021-0340. Epub 2022 Feb 7. 

PMID: 35129375 

 

Implementing a Clinical Immunogenicity Strategy using Preclinical Risk Assessment Outputs. 

Jawa V, Maamary J, Swanson M, Zhang S, Montgomery D. 

J Pharm Sci. 2022 Apr;111(4):960-969. doi: 10.1016/j.xphs.2022.01.032. Epub 2022 Feb 3. 

PMID: 35122828 

 

Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study. 

Kwon S, Ma W, Drew DA, Klempner SJ, Leonardo BM, Flynn JJ, Cao Y, Giovannucci EL, Bao Y, Fuchs CS, Song M, Chan AT. 

Cancer Prev Res (Phila). 2022 Apr 1;15(4):265-272. doi: 10.1158/1940-6207.CAPR-21-0413. 

PMID: 34980677 

 

Enzymatic removal of sialic acid enables iCIEF stability monitoring of charge variants of a highly sialylated bispecific antibody. 

Peters BH, Bautista J, Slaney TR, Guo H, Huang RY, Krause ME, Zeng M, Cheng J, Chen Z. Electrophoresis. 2022 Mar 31. doi: 10.1002/elps.202100259. Online ahead of print. 

PMID: 35362108 

 

A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease. 

Layton TB, Williams L, Yang N, Zhang M, Lee C, Feldmann M, Trujillo G, Furniss D, Nanchahal J. 

Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2120336119. doi: 10.1073/pnas.2120336119. Epub 2022 Mar 23. 

PMID: 35320046 

 

Olaparib maintenance monotherapy in Chinese patients with platinum-sensitive relapsed ovarian cancer: China cohort from the phase III SOLO2 trial. 

Liu J, Yin R, Wu L, Zhu J, Lou G, Wu X, Zhou Q, Gao Y, Kong B, Lu X, Wang J, Chen Y, Cheng Y, Wang Y, Lu W, Li W, Ma X, Hsu K. 

Asia Pac J Clin Oncol. 2022 Mar 31. doi: 10.1111/ajco.13753. Online ahead of print. 

PMID: 35357078 

 

Current Approaches for Dissolution Similarity Assessment, Requirements, and Global Expectations. 

Abend AM, Zhang L, Fredro-Kumbaradzi E, Hoffelder T, Cohen MJ, Anand O, Delvadia P, Mandula H, Zhang Z, Kotzagiorgis E, Lum S, Pereira VG, Barker A, Lavrich D, Kraemer J, Sharp-Suarez S. 

AAPS J. 2022 Mar 29;24(3):50. doi: 10.1208/s12248-022-00691-4. 

PMID: 35352186 

 

An IQ Consortium Perspective on Connecting Dissolution Methods to In Vivo Performance: Analysis of an Industrial Database and Case Studies to Propose a Workflow. 

Aburub A, Chen Y, Chung J, Gao P, Good D, Hansmann S, Hawley M, Heimbach T, Hingle M, Kesisoglou F, Li R, Rose J, Tisaert C. 

AAPS J. 2022 Mar 29;24(3):49. doi: 10.1208/s12248-022-00699-w. 

PMID: 35348922 

 

An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay. 

Yang J, Mapelli C, Wang Z, Sum CS, Hua J, Lawrence RM, Ni Y, Seiffert DA. 

Platelets. 2022 Mar 28:1-8. doi: 10.1080/09537104.2022.2053091. Online ahead of print. 

PMID: 35343875 

 

Health Care Resource Utilization and Total Costs of Care Among Patients with Diffuse Large B Cell Lymphoma Treated with Chimeric Antigen Receptor T Cell Therapy in the United States. 

Keating SJ, Gu T, Jun MP, McBride A. 

Transplant Cell Ther. 2022 Mar 27:S2666-6367(22)01186-1. doi: 10.1016/j.jtct.2022.03.021. Online ahead of print. 

PMID: 35354101 

 

Heterogeneity in Survival with Immune Checkpoint Inhibitors and Its Implications for Survival Extrapolations: A Case Study in Advanced Melanoma. 

Federico Paly V, Kurt M, Zhang L, Butler MO, Michielin O, Amadi A, Hernlund E, Johnson HM, Kotapati S, Moshyk A, Borrill J. 

MDM Policy Pract. 2022 Mar 26;7(1):23814683221089659. doi: 10.1177/23814683221089659. eCollection 2022 Jan-Jun. 

PMID: 35356551 

 

Health state utilities for beta-thalassemia: a time trade-off study. 

Martin AP, Ferri Grazzi E, Mighiu C, Chevli M, Shah F, Maher L, Shaikh A, Sagar A, Hubberstey H, Franks B, Ramos-Goñi JM, Oppe M, Tang D. 

Eur J Health Econ. 2022 Mar 26. doi: 10.1007/s10198-022-01449-7. Online ahead of print. 

PMID: 35347553 

 

Liposome-Tethered Gold Nanoparticles Triggered by Pulsed NIR Light for Rapid Liposome Contents Release and Endosome Escape. 

Veeren A, Ogunyankin MO, Shin JE, Zasadzinski JA. 

Pharmaceutics. 2022 Mar 25;14(4):701. doi: 10.3390/pharmaceutics14040701. 

PMID: 35456535 

 

Methodological Considerations in Development of UV Imaging for Characterization of Intra-Tumoral Injectables Using cAMP as a Model Substance. 

Bock F, Bøtker JP, Larsen SW, Lu X, Østergaard J. 

Int J Mol Sci. 2022 Mar 25;23(7):3599. doi: 10.3390/ijms23073599. 

PMID: 35408971 

 

Safety, pharmacokinetics, and pharmacodynamics of milvexian in healthy Japanese participants. 

Perera V, Wang Z, Lubin S, Ueno T, Shiozaki T, Chen W, Xu X, Seiffert D, DeSouza M, Murthy B.

Sci Rep. 2022 Mar 25;12(1):5165. doi: 10.1038/s41598-022-08768-y. 

PMID: 35338177 

 

Matching-adjusted indirect treatment comparison of chimeric antigen receptor T-cell therapies for third-line or later treatment of relapsed or refractory large B-cell lymphoma: lisocabtagene maraleucel versus tisagenlecleucel. 

Cartron G, Fox CP, Liu FF, Kostic A, Hasskarl J, Li D, Bonner A, Zhang Y, Maloney DG, Kuruvilla J. 

Exp Hematol Oncol. 2022 Mar 25;11(1):17. doi: 10.1186/s40164-022-00268-z. 

PMID: 35337365 

 

A Review of Overall Survival Extrapolations of Immune-Checkpoint Inhibitors Used in Health Technology Assessments by the French Health Authorities. 

Grumberg V, Roze S, Chevalier J, Borrill J, Gaudin AF, Branchoux S. 

Int J Technol Assess Health Care. 2022 Mar 25;38(1):e28. doi: 10.1017/S0266462322000125. 

PMID: 35331347 

 

Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain. 

Luo G, Chen L, Kostich WA, Hamman B, Allen J, Easton A, Bourin C, Gulianello M, Lippy J, Nara S, Pattipati SN, Dandapani K, Dokania M, Vattikundala P, Sharma V, Elavazhagan S, Verma MK, Lal Das M, Wagh S, Balakrishnan A, Johnson BM, Santone KS, Thalody G, Denton R, Saminathan H, Holenarsipur VK, Kumar A, Rao A, Putlur SP, Sarvasiddhi SK, Shankar G, Louis JV, Ramarao M, Conway CM, Li YW, Pieschl R, Tian Y, Hong Y, Bristow L, Albright CF, Bronson JJ, Macor JE, Dzierba CD.

J Med Chem. 2022 Mar 24;65(6):4534-4564. doi: 10.1021/acs.jmedchem.1c02132. Epub 2022 Mar 9. 

PMID: 35261239 

 

Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.

Luo G, Chen L, Kostich WA, Hamman B, Allen J, Easton A, Bourin C, Gulianello M, Lippy J, Nara S, Maishal TK, Thiyagarajan K, Jalagam P, Pattipati SN, Dandapani K, Dokania M, Vattikundala P, Sharma V, Elavazhagan S, Verma MK, Das ML, Wagh S, Balakrishnan A, Johnson BM, Santone KS, Thalody G, Denton R, Saminathan H, Holenarsipur VK, Kumar A, Rao A, Putlur SP, Sarvasiddhi SK, Shankar G, Louis JV, Ramarao M, Conway CM, Li YW, Pieschl R, Tian Y, Hong Y, Ditta J, Mathur A, Li J, Smith D, Pawluczyk J, Sun D, Yip S, Wu DR, Vetrichelvan M, Gupta A, Wilson A, Gopinathan S, Wason S, Bristow L, Albright CF, Bronson JJ, Macor JE, Dzierba CD. 

J Med Chem. 2022 Mar 24;65(6):4457-4480. doi: 10.1021/acs.jmedchem.1c02131. Epub 2022 Mar 8. 

PMID: 35257579 

 

The Current States, Challenges, Ongoing Efforts, and Future Perspectives of Pharmaceutical Excipients in Pediatric Patients in Each Country and Region. 

Saito J, Agrawal A, Patravale V, Pandya A, Orubu S, Zhao M, Andrews GP, Petit-Turcotte C, Landry H, Croker A, Nakamura H, Yamatani A, Salunke S. 

Children (Basel). 2022 Mar 23;9(4):453. doi: 10.3390/children9040453. 

PMID: 35455497 

 

N-1 Perfusion Platform Development Using a Capacitance Probe for Biomanufacturing. 

Rittershaus ESC, Rehmann MS, Xu J, He Q, Hill C, Swanberg J, Borys MC, Li ZJ, Khetan A. Bioengineering (Basel). 2022 Mar 22;9(4):128. doi: 10.3390/bioengineering9040128. 

PMID: 35447688 

 

Fibrotic activity quantified in serum by measurements of type III collagen pro-peptides can be used for prognosis across different solid tumor types. 

Willumsen N, Jensen C, Green G, Nissen NI, Neely J, Nelson DM, Pedersen RS, Frederiksen P, Chen IM, Boisen MK, Johansen AZ, Madsen DH, Svane IM, Lipton A, Leitzel K, Ali SM, Erler JT, Hurkmans DP, Mathijssen RHJ, Aerts J, Eslam M, George J, Christiansen C, Bissel MJ, Karsdal MA. 

Cell Mol Life Sci. 2022 Mar 25;79(4):204. doi: 10.1007/s00018-022-04226-0. 

PMID: 35332383 

 

A population-based study in synchronous versus metachronous metastatic esophagogastric adenocarcinoma. 

Pape M, Vissers PAJ, Bertwistle D, McDonald L, Slingerland M, Haj Mohammad N, Beerepoot LV, Ruurda JP, Nieuwenhuijzen GAP, Jeene PM, van Laarhoven HWM, Verhoeven RHA. 

Ther Adv Med Oncol. 2022 Mar 24;14:17588359221085557. doi: 10.1177/17588359221085557. eCollection 2022. 

PMID: 35356260 

 

A two-stage adaptive clinical trial design with data-driven subgroup identification at interim analysis. 

Johnston SE, Lipkovich I, Dmitrienko A, Zhao YD. 

Pharm Stat. 2022 Mar 24. doi: 10.1002/pst.2208. Online ahead of print. 

PMID: 35322520 

 

Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs. 

Naidu BN, Patel M, McAuliffe B, Ding B, Cianci C, Simmermacher J, Jenkins S, Parker DD, Sivaprakasam P, Khan JA, Kish K, Lewis H, Hanumegowda U, Krystal M, Meanwell NA, Kadow JF. 

J Med Chem. 2022 Mar 24;65(6):4949-4971. doi: 10.1021/acs.jmedchem.1c02169. Epub 2022 Mar 2. 

PMID: 35235334 

 

Androgen receptor activity in T cells limits checkpoint blockade efficacy. 

Guan X, Polesso F, Wang C, Sehrawat A, Hawkins RM, Murray SE, Thomas GV, Caruso B, Thompson RF, Wood MA, Hipfinger C, Hammond SA, Graff JN, Xia Z, Moran AE. 

Nature. 2022 Mar 23. doi: 10.1038/s41586-022-04522-6. Online ahead of print. 

PMID: 35322234 

 

Cold Denaturation of Proteins in the Absence of Solvent: Implications for Protein Storage. 

Norgate EL, Upton R, Hansen K, Bellina B, Brookes C, Politis A, Barran PE. 

Angew Chem Int Ed Engl. 2022 Mar 21:e202115047. doi: 10.1002/anie.202115047. Online ahead of print. 

PMID: 35313047 

 

An open-label, phase 1, randomized, three treatments, three-period, crossover, relative bioavailability study of CC-292, a potent and orally available inhibitor of bruton tyrosine kinase. 

Cheng Y, Liu L, Xue Y, Zhou S, Li Y. 

J Clin Pharm Ther. 2022 Mar 20. doi: 10.1111/jcpt.13653. Online ahead of print. 

PMID: 35307850 

 

LPA₁ antagonist BMS-986020 changes collagen dynamics and exerts antifibrotic effects in vitro and in patients with idiopathic pulmonary fibrosis. 

Decato BE, Leeming DJ, Sand JMB, Fischer A, Du S, Palmer SM, Karsdal M, Luo Y, Minnich A. 

Respir Res. 2022 Mar 18;23(1):61. doi: 10.1186/s12931-022-01980-4. 

PMID: 35303880 

 

Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus. 

Merrill JT, Werth VP, Furie R, van Vollenhoven R, Dörner T, Petronijevic M, Velasco J, Majdan M, Irazoque-Palazuelos F, Weiswasser M, Korish S, Ye Y, Gaudy A, Schafer PH, Liu Z, Agafonova N, Delev N. 

N Engl J Med. 2022 Mar 17;386(11):1034-1045. doi: 10.1056/NEJMoa2106535. 

PMID: 35294813 

 

A Systematic Approach for the Evaluation, Validation and Implementation of Automated Colony Counting Systems. 

Deutschmann S, Carpenter B, Duignan C, Knutsen C, Salvas J, Wysocki L, Plourde L, Johnson L, Eder W, Franz-Riethdorf M. 

PDA J Pharm Sci Technol. 2022 Mar 16:pdajpst.2021.012646. doi: 10.5731/pdajpst.2021.012646. Online ahead of print. 

PMID: 35296561 

 

Three-year follow-up and response-survival relationship of nivolumab in previously treated patients with advanced esophageal squamous cell carcinoma (ATTRACTION-3). 

Okada M, Kato K, Cho BC, Takahashi M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Matsumura Y, Takazawa A, Kitagawa Y. 

Clin Cancer Res. 2022 Mar 16:clincanres.0985.2021. doi: 10.1158/1078-0432.CCR-21-0985. Online ahead of print. 

PMID: 35294546 

 

Hospitalizations for Acute Gout: Process Mapping the Inpatient Journey and Identifying Predictors of Admission. 

Russell MD, Nagra D, Clarke BD, Balachandran S, Buazon A, Boalch A, Bechman K, Adas MA, Alveyn EG, Rutherford AI, Galloway JB. 

J Rheumatol. 2022 Mar 15:jrheum.211203. doi: 10.3899/jrheum.211203. Online ahead of print. 

PMID: 35293331 

 

Janus Kinase Inhibitors: Safety in Patients With Psoriatic Arthritis. 

Nash P. 

J Rheumatol. 2022 Mar 15:jrheum.211329. doi: 10.3899/jrheum.211329. Online ahead of print. 

PMID: 35293326 

 

Demographic, Lifestyle, and Serologic Risk Factors for Rheumatoid Arthritis-Associated Bronchiectasis: Role of RA-related Autoantibodies. 

McDermott G, Gill R, Gagne S, Byrne S, Huang W, Wang X, Prisco LC, Zaccardelli A, Martin LW, Masto L, Kronzer VL, Shadick N, Dellaripa PF, Doyle TJ, Sparks JA. 

J Rheumatol. 2022 Mar 15:jrheum.211242. doi: 10.3899/jrheum.211242. Online ahead of print. 

PMID: 35293341 

 

GRAPPA 2020 Research Award Recipients. 

Castillo RL, Yan D, Ashhurst AS, Elliott A, Angioni MM, Scher JU, Naik S, Neimann A, Byrne SN, Payne RJ, FitzGerald O, Pennington SR, Cauli A, Chandran V. 

J Rheumatol. 2022 Mar 15:jrheum.211335. doi: 10.3899/jrheum.211335. Online ahead of print. 

PMID: 35293338 

 

Promoting Diversity, Equity, and Inclusion for Psoriatic Diseases.

Takeshita J, Chau J, Callis Duffin K, Goel N. 

J Rheumatol. 2022 Mar 15:jrheum.211330. doi: 10.3899/jrheum.211330. Online ahead of print. 

PMID: 35293335 

 

Trends in treatment patterns and survival outcomes in advanced non-small cell lung cancer: a Canadian population-based real-world analysis. 

Carroll R, Bortolini M, Calleja A, Munro R, Kong S, Daumont MJ, Penrod JR, Lakhdari K, Lacoin L, Cheung WY. 

BMC Cancer. 2022 Mar 10;22(1):255. doi: 10.1186/s12885-022-09342-5. 

PMID: 35264135 

 

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132). 

Shi Y, Wang Y, Meng W, Brigance RP, Ryono DE, Bolton S, Zhang H, Chen S, Smirk R, Tao S, Tino JA, Williams KN, Sulsky R, Nielsen L, Ellsworth B, Wong MKY, Sun JH, Leith LW, Sun D, Wu DR, Gupta A, Rampulla R, Mathur A, Chen BC, Wang A, Fuentes-Catanio HG, Kunselman L, Cap M, Zalaznick J, Ma X, Liu H, Taylor JR, Zebo R, Jones B, Kalinowski S, Swartz J, Staal A, O'Malley K, Kopcho L, Muckelbauer JK, Krystek SR Jr, Spronk SA, Marcinkeviciene J, Everlof G, Chen XQ, Xu C, Li YX, Langish RA, Yang Y, Wang Q, Behnia K, Fura A, Janovitz EB, Pannacciulli N, Griffen S, Zinker BA, Krupinski J, Kirby M, Whaley J, Zahler R, Barrish JC, Robl JA, Cheng PTW. 

J Med Chem. 2022 Mar 10;65(5):4291-4317. doi: 10.1021/acs.jmedchem.1c02110. Epub 2022 Feb 18. 

PMID: 35179904 

 

Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. 

Hartz RA, Ahuja VT, Nara SJ, Kumar CMV, Manepalli RKVLP, Sarvasiddhi SK, Honkhambe S, Patankar V, Dasgupta B, Rajamani R, Muckelbauer JK, Camac DM, Ghosh K, Pokross M, Kiefer SE, Brown JM, Hunihan L, Gulianello M, Lewis M, Lippy JS, Surti N, Hamman BD, Allen J, Kostich WA, Bronson JJ, Macor JE, Dzierba CD. 

J Med Chem. 2022 Mar 10;65(5):4121-4155. doi: 10.1021/acs.jmedchem.1c01966. Epub 2022 Feb 16. 

PMID: 35171586 

 

Health-related Quality of Life with Adjuvant Nivolumab After Radical Resection for High-risk Muscle-invasive Urothelial Carcinoma: Results from the Phase 3 CheckMate 274 Trial. 

Witjes JA, Galsky MD, Gschwend JE, Broughton E, Braverman J, Nasroulah F, Maira-Arce M, Ye X, Shi L, Guo S, Hamilton M, Bajorin DF. 

Eur Urol Oncol. 2022 Mar 11:S2588-9311(22)00028-1. doi: 10.1016/j.euo.2022.02.003. Online ahead of print. 

PMID: 35288066 

 

Treatment Patterns, Health Care Resource Utilization, and Cost in Patients with Myelofibrosis in the United States. 

Copher R, Kee A, Gerds A.

Oncologist. 2022 Mar 11;27(3):228-235. doi: 10.1093/oncolo/oyab058. 

PMID: 35274711 

 

Homologous Recombination Deficiency: Concepts, Definitions, and Assays. 

Stewart MD, Merino Vega D, Arend RC, Baden JF, Barbash O, Beaubier N, Collins G, French T, Ghahramani N, Hinson P, Jelinic P, Marton MJ, McGregor K, Parsons J, Ramamurthy L, Sausen M, Sokol ES, Stenzinger A, Stires H, Timms KM, Turco D, Wang I, Williams JA, Wong-Ho E, Allen J. Oncologist. 2022 Mar 11;27(3):167-174. doi: 10.1093/oncolo/oyab053. 

PMID: 35274707 

 

Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles. 

Jecs E, Tahirovic YA, Wilson RJ, Miller EJ, Kim M, Truax V, Nguyen HH, Akins NS, Saindane M, Wang T, Sum CS, Cvijic ME, Schroeder GM, Burton SL, Derdeyn CA, Xu L, Jiang Y, Wilson LJ, Liotta DC. 

J Med Chem. 2022 Mar 10;65(5):4058-4084. doi: 10.1021/acs.jmedchem.1c01564. Epub 2022 Feb 18. 

PMID: 35179893 

 

Single-Dose Pharmacokinetics of Milvexian in Participants with Mild or Moderate Hepatic Impairment Compared with Healthy Participants. 

Perera V, Abelian G, Li D, Wang Z, Zhang L, Lubin S, Chen W, Bello A, Murthy B. 

Clin Pharmacokinet. 2022 Mar 9. doi: 10.1007/s40262-022-01110-9. Online ahead of print.

PMID: 35262846 

 

Comparative cost-effectiveness of radiotherapy among older women with hormone receptor positive early-stage breast cancer. 

Ali AA, Tawk R, Xiao H, Semykina A, Montero AJ, Moussa RK, Popoola O, Diaby V. 

Expert Rev Pharmacoecon Outcomes Res. 2022 Mar 9:1-7. doi: 10.1080/14737167.2022.2044309. Online ahead of print. 

PMID: 35189767 

 

Lenalidomide enhances CD23.CAR T cell therapy in chronic lymphocytic leukemia. 

Tettamanti S, Rotiroti MC, Giordano Attianese GMP, Arcangeli S, Zhang R, Banerjee P, Galletti G, McManus S, Mazza M, Nicolini F, Martinelli G, Ivan C, Veliz Rodriguez T, Barbaglio F, Scarfò L, Ponzoni M, Wierda W, Gandhi V, Keating M, Biondi A, Caligaris-Cappio F, Biagi E, Ghia P, Bertilaccio MTS. 

Leuk Lymphoma. 2022 Mar 8:1-14. doi: 10.1080/10428194.2022.2043299. Online ahead of print. 

PMID: 35259043 

 

Formyl peptide receptor 2 and heart disease. 

Lupisella JA, Shirude PS, Wurtz NR, Garcia RA. 

Semin Immunol. 2022 Mar 8:101602. doi: 10.1016/j.smim.2022.101602. Online ahead of print. 

PMID: 35277300 

 

Phase I study of taminadenant (PBF509/NIR178), an adenosine 2A receptor antagonist, with or without spartalizumab, in patients with advanced non-small cell lung cancer. 

Chiappori AA, Creelan B, Tanvetyanon T, Gray JE, Haura EB, Thapa R, Barlow ML, Chen Z, Chen DT, Beg AA, Boyle TA, Castro J, Morgan L, Morris E, Aregay M, Hurtado FK, Manenti L, Antonia S. 

Clin Cancer Res. 2022 Mar 7:clincanres.2742.2021. doi: 10.1158/1078-0432.CCR-21-2742. Online ahead of print. 

PMID: 35254415 

 

Understanding Poor Milling Behavior of Voriconazole from Crystal Structure and Intermolecular Interactions. 

Kaur A, Yadav JP, Sathe RY, Puri V, Bharatam PV, Bansal AK.

Mol Pharm. 2022 Mar 7;19(3):985-997. doi: 10.1021/acs.molpharmaceut.1c00978. Epub 2022 Feb 21. 

PMID: 35188397