Research Publications

Our researchers, scientists and clinical partners are active members of the scientific community and have published their work in well-respected, peer-reviewed journals.

NOTE: The links provided below redirect to third-party websites that may require a subscription to access publications.

2021 Publications

Updated results of the placebo-controlled, phase III JAKARTA trial of fedratinib in patients with intermediate-2 or high-risk myelofibrosis.

Pardanani A, Tefferi A, Masszi T, Mishchenko E, Drummond M, Jourdan E, Vannucchi A, Jurgutis M, Ribrag V, Rambaldi A, Koh LP, Rose S, Zhang J, Harrison C.Br J Haematol. 2021 Jul 30. doi: 10.1111/bjh.17727. Online ahead of print.

PMID: 34331348

Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W.

Davies CW, Vidal SE, Phu L, Sudhamsu J, Hinkle TB, Chan Rosenberg S, Schumacher FR, Zeng YJ, Schwerdtfeger C, Peterson AS, Lill JR, Rose CM, Shaw AS, Wertz IE, Kirkpatrick DS, Koerber JT, et al.

Nat Commun. 2021 Jul 29;12(1):4608. doi: 10.1038/s41467-021-24669-6.

PMID: 34326324

Self-reporting data assets and their representation in the pharmaceutical industry.

Della Corte D, Colsman W, Fessenmayr H, Sawczuk da Silva A, Vanderwall DE, et al.

Drug Discov Today. 2021 Jul 28:S1359-6446(21)00328-7. doi: 10.1016/j.drudis.2021.07.019. Online ahead of print.

PMID: 34332096

Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration.

Anderson KC, Auclair D, Adam SJ, Agarwal A, Anderson M, Avet-Loiseau H, Bustoros M, Chapman J, Connors DE, Dash A, Di Bacco A, Du L, Facon T, Flores-Montero J, Gay F, Ghobrial IM, Gormley NJ, Gupta I, Higley H, Hillengass J, Kanapuru B, Kazandjian D, Kelloff GJ, Kirsch IR, Kremer BE, Landgren O, Lightbody ED, Lomas OC, Lonial S, Mateos MV, Montes de Oca R, Mukundan L, Munshi NC, O'Donnell EK, Orfao A, Paiva B, Patel R, Pugh TJ, Ramasamy K, Ray J, Roshal M, Ross JA, Sigman CC, Thoren KL, Trudel S, Ulaner GA, Valente N, Weiss BM, Zamagni E, Kumar SK, et al.

Clin Cancer Res. 2021 Jul 28:clincanres.1059.2021. doi: 10.1158/1078-0432.CCR-21-1059. Online ahead of print.

PMID: 34321279

Real-World Treatment Patterns and Outcomes in Patients with Head and Neck Cancer: Point-in-Time Survey of Oncologists in Italy and Spain.

Singh P, Contente M, Bennett B, Hall J, Bailey H, Bailey A, Zarrelli L, Polanco Sanchez C, et al.

Adv Ther. 2021 Jul 28. doi: 10.1007/s12325-021-01851-2. Online ahead of print.

PMID: 34319551

Response to upfront azacitidine in juvenile myelomonocytic leukemia in the AZA-JMML-001 trial.

Niemeyer CM, Flotho C, Lipka DB, Starý J, Rössig C, Baruchel A, Klingebiel T, Micalizzi C, Michel G, Nysom K, Rives S, Schmugge Liner M, Zecca M, Schönung M, Baumann I, Nöllke P, Benettaib B, Biserna N, Poon J, Simcock M, Patturajan M, Menezes D, Gaudy A, van den Heuvel-Eibrink MM, Locatelli F, et al.

Blood Adv. 2021 Jul 27;5(14):2901-2908. doi: 10.1182/bloodadvances.2020004144.

PMID: 34297046

Comparing the downstream costs and healthcare utilization associated with the use of low-dose computed tomography (LDCT) in lung cancer screening in patients with and without alzheimer's disease and related dementias (ADRD).

Zhang Y, Bian J, Huo J, Yang S, Guo Y, Shao H, et al.

Curr Med Res Opin. 2021 Jul 26:1-7. doi: 10.1080/03007995.2021.1953972. Online ahead of print.

PMID: 34252317

Heterogeneity of treatment effects in malignant pleural mesothelioma - Authors' reply.

Baas P, Scherpereel A, Nowak AK, Oukessou A, Zalcman G, et al.

Lancet. 2021 Jul 24;398(10297):302. doi: 10.1016/S0140-6736(21)00876-X.

PMID: 34303436

Real-world study of the impact of recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) on quality of life and productivity in Europe.

Singh P, Bennett B, Bailey T, Taylor-Stokes G, Rajkovic I, Contente M, Curtis S, Curtis C, et al.

BMC Cancer. 2021 Jul 24;21(1):854. doi: 10.1186/s12885-021-08557-2.

PMID: 34303346

Access to Chimeric Antigen Receptor T Cell Therapy for Diffuse Large B Cell Lymphoma.

Snyder S, Chung KC, Jun MP, Gitlin M, et al.

Adv Ther. 2021 Jul 23. doi: 10.1007/s12325-021-01838-z. Online ahead of print.

PMID: 34302277

Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on αv Integrins.

Gallo E, Kelil A, Haughey M, Cazares-Olivera M, Yates BP, Zhang M, Wang NY, Blazer L, Carderelli L, Adams JJ, Kossiakoff AA, Wells JA, Xie W, Sidhu SS, et al.

J Mol Biol. 2021 Jul 23;433(15):167090. doi: 10.1016/j.jmb.2021.167090. Epub 2021 Jun 4.

PMID: 34090922

Specific White Matter Tracts and Diffusion Properties Predict Conversion From Mild Cognitive Impairment to Alzheimer's Disease.

Stone DB, Ryman SG, Hartman AP, Wertz CJ, Vakhtin AA; Alzheimer’s Disease Neuroimaging Initiative.

Front Aging Neurosci. 2021 Jul 23;13:711579. doi: 10.3389/fnagi.2021.711579. eCollection 2021.

PMID: 34366830

DGKζ exerts greater control than DGKα over CD8⁺ T cell activity and tumor inhibition.

Gu J, Wang C, Cao C, Huang J, Holzhauer S, Desilva H, Wesley EM, Evans DB, Benci J, Wichroski M, Wee S, Riese MJ, et al.

Oncoimmunology. 2021 Jul 21;10(1):1941566. doi: 10.1080/2162402X.2021.1941566. eCollection 2021.

PMID: 34350062

Treatment patterns and outcomes in elderly patients with newly diagnosed multiple myeloma: results from the Connect^® MM Registry.

Lee HC, Ailawadhi S, Gasparetto CJ, Jagannath S, Rifkin RM, Durie BGM, Narang M, Terebelo HR, Toomey K, Hardin JW, Wagner L, Omel JL, Dhalla M, Liu L, Joshi P, Abonour R; Connect® MM Registry.

Blood Cancer J. 2021 Jul 23;11(7):134. doi: 10.1038/s41408-021-00524-1.

PMID: 34301916

Plasma neurofilament light chain concentrations as a biomarker of clinical and radiologic outcomes in relapsing multiple sclerosis: Post hoc analysis of phase 3 ozanimod trials.

Harris S, Comi G, Cree BAC, Arnold DL, Steinman L, Sheffield JK, Southworth H, Kappos L, Cohen JA; ozanimod study investigators.

Eur J Neurol. 2021 Jul 22. doi: 10.1111/ene.15009. Online ahead of print.

PMID: 34292643

Transcriptome analysis reveals key genes modulated by ALK5 inhibition in a bleomycin model of systemic sclerosis.

Decato BE, Ammar R, Reinke-Breen L, Thompson JR, Azzara AV, et al.

Rheumatology (Oxford). 2021 Jul 21:keab580. doi: 10.1093/rheumatology/keab580. Online ahead of print.

PMID: 34289031

Developing next generation immunomodulatory drugs and their combinations in multiple myeloma.

Thakurta A, Pierceall WE, Amatangelo MD, Flynt E, Agarwal A, et al.

Oncotarget. 2021 Jul 20;12(15):1555-1563. doi: 10.18632/oncotarget.27973. eCollection 2021 Jul 20.

PMID: 34316334

Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols.

Baran PS, Zhang HJ, Chen L, Oderinde MS, Edwards JT, Kawamata Y, et al.

Angew Chem Int Ed Engl. 2021 Jul 20. doi: 10.1002/anie.202107820. Online ahead of print.

PMID: 34288303

Small cell lung cancer treatment and survival in Portugal: A retrospective analysis from the I-O Optimise initiative.

Soares M, Antunes L, Redondo P, Borges M, Grimson F, Hermans R, Chaib C, Lacoin L, Juarez-Garcia A, Daumont MJ, Penrod JR, Bento MJ, Gonçalves FR, et al.

Eur J Cancer Care (Engl). 2021 Jul 20:e13496. doi: 10.1111/ecc.13496. Online ahead of print.

PMID: 34288191

Equivalence testing of a newly developed interviewer-led telephone script for the EORTC QLQ-C30.

Piccinin C, Pe M, Kuliś D, Shaw JW, Wheelwright SJ, Bottomley A, et al.

Qual Life Res. 2021 Jul 20. doi: 10.1007/s11136-021-02955-6. Online ahead of print.

PMID: 34286416

The PROTACtable genome.

Schneider M, Radoux CJ, Hercules A, Ochoa D, Dunham I, Zalmas LP, Hessler G, Ruf S, Shanmugasundaram V, Hann MM, Thomas PJ, Queisser MA, Benowitz AB, Brown K, Leach AR, et al.

Nat Rev Drug Discov. 2021 Jul 20. doi: 10.1038/s41573-021-00245-x. Online ahead of print.

PMID: 34285415

Impact of open-label versus blinded study design on patient-reported outcomes data in randomized clinical trials of immunotherapy in advanced or metastatic cancer patients: a systematic review.

Anota A, Pozet A, Lemasson H, Cotté FE, Falcoz A, Eberst G, Mouillet G, Guerzider S, Charton É, Westeel V, et al.

Qual Life Res. 2021 Jul 20. doi: 10.1007/s11136-021-02945-8. Online ahead of print.

PMID: 34283382

Predictors of 30-day readmission and hospitalization costs of patients with hepatic encephalopathy in the US from 2010 to 2014.

Chen Z, Babcock A, Sanogo V, Nelson DR, Xiao H, Diaby V, et al.

Expert Rev Pharmacoecon Outcomes Res. 2021 Jul 16:1-7. doi: 10.1080/14737167.2021.1927717. Online ahead of print.

PMID: 33985399

Cereblon pathway biomarkers and immune profiles in patients with myeloma receiving post-ASCT lenalidomide maintenance (LEOPARD).

Kalff A, Khong T, Ramachandran M, Walker P, Schwarer A, Roberts AW, Campbell P, Filshie R, Norton S, Reynolds J, Young M, Pierceall W, Thakurta A, Guo M, Oppermann U, Wang M, Ren Y, Kennedy N, Parekh S, Spencer A, et al.

Leuk Lymphoma. 2021 Jul 15:1-11. doi: 10.1080/10428194.2021.1948030. Online ahead of print.

PMID: 34263697

Investigation on hot melt extrusion and prediction on 3D printability of pharmaceutical grade polymers.

Tabriz AG, Scoutaris N, Gong Y, Hui HW, Kumar S, Douroumis D, et al.

Int J Pharm. 2021 Jul 15;604:120755. doi: 10.1016/j.ijpharm.2021.120755. Epub 2021 May 28.

PMID: 34052338

Stereoselective and Divergent Aza-Adenosine and Aza-Guanosine Syntheses from Xylofuranose, the Key Fragments of a STING Cyclic Dinucleotide Agonist.

Yuan C, Ortiz A, Xu Z, Zhu J, Schmidt MA, Rogers A, Eastgate M, et al.

J Org Chem. 2021 Jul 14. doi: 10.1021/acs.joc.1c00984. Online ahead of print.

PMID: 34259509

Effect of Baseline Disease Severity on Achievement of Treatment Target With Apremilast: Results From a Pooled Analysis.

Reich K, Mrowietz U, Menter A, Griffiths CEM, Bagel J, Strober B, Nunez Gomez N, Shi R, Guerette B, Lebwohl M, et al.

J Eur Acad Dermatol Venereol. 2021 Jul 13. doi: 10.1111/jdv.17520. Online ahead of print.

PMID: 34255891

The use of proxies and proxy-reported measures: a report of the international society for quality of life research (ISOQOL) proxy task force.

Roydhouse JK, Cohen ML, Eshoj HR, Corsini N, Yucel E, Rutherford C, Wac K, Berrocal A, Lanzi A, Nowinski C, Roberts N, Kassianos AP, Sebille V, King MT, Mercieca-Bebber R; ISOQOL Proxy Task Force and the ISOQOL Board of Directors.

Qual Life Res. 2021 Jul 12. doi: 10.1007/s11136-021-02937-8. Online ahead of print.

PMID: 34254262

Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody.

Narla RK, Modi H, Bauer D, Abbasian M, Leisten J, Piccotti JR, Kopytek S, Eckelman BP, Deveraux Q, Timmer J, Zhu D, Wong L, Escoubet L, Raymon HK, Hariharan K, et al.

Cancer Immunol Immunother. 2021 Jul 10. doi: 10.1007/s00262-021-03010-6. Online ahead of print.

PMID: 34247273

Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies.

Awosemo O, Neelakantan H, Watowich S, Ma J, Wu L, Chow DS, Liang D, et al.

J Pharm Biomed Anal. 2021 Jul 8;204:114255. doi: 10.1016/j.jpba.2021.114255. Online ahead of print.

PMID: 34304009

The importance of specific citrullinated clusterin and vimentin found in a multi-coloured bead-based citrulline-peptide array system in rheumatoid arthritis.

Yoshizawa Y, Nakao T, Tsuritani K, Yamada T, Watanabe N, Chiba A, Robinson WH, Miyake S, et al.

Clin Exp Rheumatol. 2021 Jul 8. Online ahead of print.

PMID: 34251306

The obesity paradox may not lead to functional gains in stroke patients undergoing acute inpatient rehabilitation.

Freeman C, Blough A, Rotich D, Curl A, Eickmeyer SM, et al.

PM R. 2021 Jul 8. doi: 10.1002/pmrj.12671. Online ahead of print.

PMID: 34240565

Synthesis and characterization of a series of N, N'-substituted urea derivatives by using electrospray ionization tandem mass spectrometry (ESI-MS/MS): Differentiation of positional isomers.

Singh DK, Chauthe SK, Anjanappa P, Kumar S, Arulraj RA, Gajjela R, Mohammed N, Kanthappa VT, Karmakar A, Gupta AK, Bajpai L, Bagadi M, Mathur A, et al.

Rapid Commun Mass Spectrom. 2021 Jul 8:e9161. doi: 10.1002/rcm.9161. Online ahead of print.

PMID: 34240514

Thymic lymphomas in a 6-Month rasH2-Tg mouse carcinogenicity study with the RORγt Inverse Agonist, BMS-986251.

Haggerty HG, Sathish JG, Gleason CR, Al-Haddawi M, Brodie TA, Bonnette KL, Lewis BS, Graziano MJ, et al.

Toxicol Sci. 2021 Jul 8:kfab086. doi: 10.1093/toxsci/kfab086. Online ahead of print.

PMID: 34240189

Author Correction: A one-step tRNA-CRISPR system for genome-wide genetic interaction mapping in mammalian cells.

Zhao Y, Tyrishkin K, Sjaarda C, Khanal P, Stafford J, Rauh M, Liu X, Babak T, Yang X, et al.

Sci Rep. 2021 Jul 8;11(1):14483. doi: 10.1038/s41598-021-92514-3.

PMID: 34238941

Patient and neurologist preferences in the UK for relapsing-remitting multiple sclerosis treatments: findings from a discrete choice experiment.

Tencer T, Will O, Kumar J, Cambron-Mellott MJ, Mackie DS, Beusterien K, et al.

Curr Med Res Opin. 2021 Jul 8:1-10. doi: 10.1080/03007995.2021.1940911. Online ahead of print.

PMID: 34129418

Patient and Neurologist Preferences in the United States for Relapsing-Remitting Multiple Sclerosis Treatments: Findings from a Discrete Choice Experiment.

Kumar J, Cambron-Mellott MJ, Tencer T, Will O, Mackie DS, Beusterien K, et al.

Patient Prefer Adherence. 2021 Jul 8;15:1515-1527. doi: 10.2147/PPA.S306498. eCollection 2021.

PMID: 34267507

Covid-19 Knowledge and Perceptions Among Dental Specialists: A Cross-Sectional Online Questionnaire Survey.

Aldhuwayhi S, Mallineni SK, Sakhamuri S, Thakare AA, Mallineni S, Sajja R, Sethi M, Nettam V, Mohammad AM, et al.

Risk Manag Healthc Policy. 2021 Jul 7;14:2851-2861. doi: 10.2147/RMHP.S306880. eCollection 2021.

PMID: 34262372

P(III) vs P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to an Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist.

Zheng B, Hang C, Zhu J, Purdum GE, Sezen-Edmonds M, Treitler DS, Yu M, Yuan C, Zhu Y, Freitag A, Guo S, Zhu G, Hritzko B, Paulson J, Shackman JG, He BL, Fu W, Tai HC, Ayers S, Park H, Eastgate MD, Cohen B, Rogers A, Wang Q, Schmidt MA, et al.

J Org Chem. 2021 Jul 7. doi: 10.1021/acs.joc.1c01055. Online ahead of print.

PMID: 34232659

Predictive immune checkpoint blockade classifiers identify tumors responding to inhibition of PD-1 and/or CTLA-4.

Krijgsman O, Kemper K, Boshuizen J, Vredevoogd DW, Rozeman EA, Ibanez Molero S, de Bruijn B, Cornelissen-Steijger P, Shahrabi A, Del Castillo Velasco-Herrera M, Song JY, Ligtenberg MA, Kluin RJC, Kuilman T, Ross-Macdonald P, Haanen J, Adams DJ, Blank C, Peeper DS, et al.

Clin Cancer Res. 2021 Jul 6:clincanres.CCR-20-4218-A.2020. doi: 10.1158/1078-0432.CCR-20-4218. Online ahead of print.

PMID: 34230026

Molecular mechanism of interspecies differences in the binding affinity of TD139 to Galectin-3.

Kumar A, Paul M, Panda M, Jayaram S, Kalidindi N, Sale H, Vetrichelvan M, Gupta A, Mathur A, Beno B, Regueiro-Ren A, Cheng D, Ramarao M, Ghosh K, et al.

Glycobiology. 2021 Jul 6:cwab072. doi: 10.1093/glycob/cwab072. Online ahead of print.

PMID: 34228782

Qualitative and psychometric approaches to evaluate the PROMIS pain interference and sleep disturbance item banks for use in patients with rheumatoid arthritis.

Becker B, Raymond K, Hawkes C, Foster AM, Lovley A, Saucier C, Rizio AA, Bjorner JB, Kosinski M, et al.

J Patient Rep Outcomes. 2021 Jul 6;5(1):52. doi: 10.1186/s41687-021-00318-w.

PMID: 34228217

The Transcriptome of Paired Major and Minor Salivary Gland Tissue in Patients With Primary Sjögren's Syndrome.

Verstappen GM, Gao L, Pringle S, Haacke EA, van der Vegt B, Liefers SC, Patel V, Hu Y, Mukherjee S, Carman J, Menard LC, Spijkervet FKL, Vissink A, Bootsma H, Kroese FGM, et al.

Front Immunol. 2021 Jul 6;12:681941. doi: 10.3389/fimmu.2021.681941. eCollection 2021.

PMID: 34295332

Acute Effects of Pimobendan on Cardiac Function in Dogs With Tachycardia Induced Dilated Cardiomyopathy: A Randomized, Placebo-Controlled, Crossover Study.

Abbott-Johnson K, Pierce KV, Roof S, Del Rio CL, Hamlin R, et al.

Front Vet Sci. 2021 Jul 1;8:646437. doi: 10.3389/fvets.2021.646437. eCollection 2021.

PMID: 34277749

High-Throughput Screening to Identify Small Molecules That Selectively Inhibit APOL1 Protein Level in Podocytes.

Choy J, Kan Y, Cifelli S, Johnson J, Chen M, Shiao LL, Zhou H, Previs S, Lei Y, Johnstone R, Liaw A, Saigal A, Hu L, Ramos R, Visconti R, McElroy WT, Kreamer A, Wildey MJ, Peier A, Shin MK, Imbriglio J, Ren Z, Hoek M, Weinglass A, Ai X, et al.

SLAS Discov. 2021 Jul 3:24725552211026245. doi: 10.1177/24725552211026245. Online ahead of print.

PMID: 34218698

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial.

Janjigian YY, Shitara K, Moehler M, Garrido M, Salman P, Shen L, Wyrwicz L, Yamaguchi K, Skoczylas T, Campos Bragagnoli A, Liu T, Schenker M, Yanez P, Tehfe M, Kowalyszyn R, Karamouzis MV, Bruges R, Zander T, Pazo-Cid R, Hitre E, Feeney K, Cleary JM, Poulart V, Cullen D, Lei M, Xiao H, Kondo K, Li M, Ajani JA, et al.

Lancet. 2021 Jul 3;398(10294):27-40. doi: 10.1016/S0140-6736(21)00797-2. Epub 2021 Jun 5.

PMID: 34102137

Correction to: Population Cellular Kinetics of Lisocabtagene Maraleucel, an Autologous CD19-Directed Chimeric Antigen Receptor T-Cell Product, in Patients with Relapsed/Refractory Large B-Cell Lymphoma.

Ogasawara K, Dodds M, Mack T, Lymp J, Dell'Aringa J, Smith J, et al.

Clin Pharmacokinet. 2021 Jul 3. doi: 10.1007/s40262-021-01055-5. Online ahead of print.

PMID: 34216384

Phylogenetic and Phylodynamic Analyses of HCV Strains Circulating among Patients Using Injectable Drugs in Central Italy.

Minosse C, Salichos L, Taibi C, Luzzitelli I, Nardozi D, Capobianchi MR, D'Offizi G, McPhee F, Garbuglia AR, et al.

Microorganisms. 2021 Jul 2;9(7):1432. doi: 10.3390/microorganisms9071432.

PMID: 34361868

Gordon J, Stainthorpe A, Jones B, Jacob I, Hertel N, Diaz J, Yuan Y, Borrill J, et al.

Pharmacoecon Open. 2021 Jul 2. doi: 10.1007/s41669-021-00279-2. Online ahead of print.

PMID: 34216002

Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform.

Xia Y, Ji X, Jang IS, Surka C, Hsu C, Wang K, Rolfe M, Bence N, Lu G, et al.

Commun Biol. 2021 Jul 2;4(1):834. doi: 10.1038/s42003-021-02352-2.

PMID: 34215850

Ni-Catalyzed 1,2-Diarylation of Alkenyl Ketones: A Comparative Study of Carbonyl-Directed Reaction Systems.

Kleinmans R, Apolinar O, Derosa J, Karunananda MK, Li ZQ, Tran VT, Wisniewski SR, Engle KM, et al.

Org Lett. 2021 Jul 16;23(14):5311-5316. doi: 10.1021/acs.orglett.1c01447. Epub 2021 Jul 2.

PMID: 34213351

Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.

Wu YJ, Meanwell NA, et al.

J Med Chem. 2021 Jul 22;64(14):9786-9874. doi: 10.1021/acs.jmedchem.1c00790. Epub 2021 Jul 2.

PMID: 34213340

Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study.

Taube JM, Roman K, Engle EL, Wang C, Ballesteros-Merino C, Jensen SM, McGuire J, Jiang M, Coltharp C, Remeniuk B, Wistuba I, Locke D, Parra ER, Fox BA, Rimm DL, Hoyt C, et al.

J Immunother Cancer. 2021 Jul;9(7):e002197. doi: 10.1136/jitc-2020-002197.

PMID: 34266881

Tumor burden limits bispecific antibody efficacy through T cell exhaustion averted by concurrent cytotoxic therapy.

Meermeier EW, Welsh SJ, Sharik ME, Du MT, Garbitt VM, Riggs DL, Shi CX, Stein CK, Bergsagel M, Chau B, Wheeler ML, Bezman N, Wang F, Strop P, Leif Bergsagel P, Chesi M, et al.

Blood Cancer Discov. 2021 Jul;2(4):354-369. doi: 10.1158/2643-3230.bcd-21-0038.

PMID: 34258584

Dose specific effectiveness and safety of DOACs in patients with non-valvular atrial fibrillation: A Canadian retrospective cohort study.

Rahme E, Godin R, Nedjar H, Dasgupta K, Tagalakis V, et al.

Thromb Res. 2021 Jul;203:121-130. doi: 10.1016/j.thromres.2021.05.005. Epub 2021 May 11.

PMID: 34000493

A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist.

Kempson J, Zhang H, Hou X, Cornelius L, Zhao R, Wang B, Hong Z, Oderinde MS, Pawluczyk J, Wu DR, Sun D, Li P, Yip S, Smith A, Caceres-Cortes J, Aulakh D, Sarjeant AA, Park PK, Harikrishnan LS, Qin LY, Dodd DS, Fink B, Vite G, Mathur A, et al.

J Org Chem. 2021 Jul 2;86(13):8851-8861. doi: 10.1021/acs.joc.1c00784. Epub 2021 Jun 14.

PMID: 34126006

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq.

Philpott M, Watson J, Thakurta A, Brown T Jr, Brown T Sr, Oppermann U, Cribbs AP, et al.

Nat Biotechnol. 2021 Jul 1. doi: 10.1038/s41587-021-00965-w. Online ahead of print.

PMID: 34211161

Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals.

Kosmicki JA, Horowitz JE, Banerjee N, Lanche R, Marcketta A, Maxwell E, Bai X, Sun D, Backman JD, Sharma D, Kury FSP, Kang HM, O'Dushlaine C, Yadav A, Mansfield AJ, Li AH, Watanabe K, Gurski L, McCarthy SE, Locke AE, Khalid S, O'Keeffe S, Mbatchou J, Chazara O, Huang Y, Kvikstad E, O'Neill A, Nioi P, Parker MM, Petrovski S, Runz H, Szustakowski JD, Wang Q, Wong E, Cordova-Palomera A, Smith EN, Szalma S, Zheng X, Esmaeeli S, Davis JW, Lai YP, Chen X, Justice AE, Leader JB, Mirshahi T, Carey DJ, Verma A, Sirugo G, Ritchie MD, Rader DJ, Povysil G, Goldstein DB, Kiryluk K, Pairo-Castineira E, Rawlik K, Pasko D, Walker S, Meynert A, Kousathanas A, Moutsianas L, Tenesa A, Caulfield M, Scott R, Wilson JF, Baillie JK, Butler-Laporte G, Nakanishi T, Lathrop M, Richards JB; Regeneron Genetics Center; UKB Exome Sequencing Consortium, Jones M, Balasubramanian S, Salerno W, Shuldiner AR, Marchini J, Overton JD, Habegger L, Cantor MN, Reid JG, Baras A, Abecasis GR, Ferreira MAR, et al.

Am J Hum Genet. 2021 Jul 1;108(7):1350-1355. doi: 10.1016/j.ajhg.2021.05.017. Epub 2021 Jun 3.

PMID: 34115965

Spectrum and Outcome of Noninfectious Aortitis.

Ferfar Y, Morinet S, Espitia O, Agard C, Vautier M, Comarmond C, Desbois AC, Domont F, Resche-Rigon M, Cacoub P, Biard L, Saadoun D; French Study Group for Large Vessel Vasculitis (GEFA), et al.

J Rheumatol. 2021 Jul 1:jrheum.201274. doi: 10.3899/jrheum.201274. Online ahead of print.

PMID: 34210830

The future of immune checkpoint combinations with tumor-targeted small molecule drugs.

Sceneay J, Sinclair C, et al.

Emerg Top Life Sci. 2021 Jul 1:ETLS20210064. doi: 10.1042/ETLS20210064. Online ahead of print.

PMID: 34196724

Nivolumab exposure-response analysis for adjuvant treatment of melanoma supporting a change in posology.

Sanghavi K, Vuppala P, Ivaturi V, Hamuro L, Roy A, Suryawanshi S, et al.

CPT Pharmacometrics Syst Pharmacol. 2021 Jul;10(7):748-759. doi: 10.1002/psp4.12642. Epub 2021 Jun 11.

PMID: 33955714

Pharmacokinetics and tolerability of apremilast in healthy Korean adult men.

Huh KY, Choi Y, Nissel J, Palmisano M, Wang X, Liu L, Ramirez-Valle F, Lee H, et al.

Clin Transl Sci. 2021 Jul;14(4):1505-1511. doi: 10.1111/cts.13013. Epub 2021 May 1.

PMID: 33932093

Process analytics 4.0: A paradigm shift in rapid analytics for biologics development.

Wasalathanthri DP, Shah R, Ding J, Leone A, Li ZJ, et al.

Biotechnol Prog. 2021 Jul;37(4):e3177. doi: 10.1002/btpr.3177. Epub 2021 May 31.

PMID: 34036755

Absence of Association Between Abatacept Exposure and Initial Infection in Patients With Juvenile Idiopathic Arthritis.

Ruperto N, Brunner HI, Tzaribachev N, Vega-Cornejo G, Louw I, Cimaz R, Dare J, Espada G, Faugier E, Ferrandiz M, Gerloni V, Quartier P, Silva CA, Wagner-Weiner L, Gandhi Y, Passarell J, Nys M, Wong R, Martini A, Lovell DJ; Pediatric Rheumatology Collaborative Study Group (PRCSG) and the Paediatric Rheumatology International Trials Organisation (PRINTO).

J Rheumatol. 2021 Jul;48(7):1073-1081. doi: 10.3899/jrheum.200154. Epub 2021 Jan 15.

PMID: 33452173

Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank.

Szustakowski JD, Balasubramanian S, Kvikstad E, Khalid S, Bronson PG, Sasson A, Wong E, Liu D, Wade Davis J, Haefliger C, Katrina Loomis A, Mikkilineni R, Noh HJ, Wadhawan S, Bai X, Hawes A, Krasheninina O, Ulloa R, Lopez AE, Smith EN, Waring JF, Whelan CD, Tsai EA, Overton JD, Salerno WJ, Jacob H, Szalma S, Runz H, Hinkle G, Nioi P, Petrovski S, Miller MR, Baras A, Mitnaul LJ, Reid JG; UKB-ESC Research Team.

Nat Genet. 2021 Jul;53(7):942-948. doi: 10.1038/s41588-021-00885-0. Epub 2021 Jun 28.

PMID: 34183854

Development and Performance of a CD8 Gene Signature for Characterizing Inflammation in the Tumor Microenvironment across Multiple Tumor Types.

Szabo PM, Pant S, Ely S, Desai K, Anguiano E, Wang L, Edwards R, Green G, Zhang N, et al.

J Mol Diagn. 2021 Jun 29:S1525-1578(21)00172-0. doi: 10.1016/j.jmoldx.2021.06.002. Online ahead of print.

PMID: 34197924

Micafungin-Induced Cell Wall Damage Stimulates Morphological Changes Consistent with Microcycle Conidiation in Aspergillus nidulans.

Reese S, Chelius C, Riekhof W, Marten MR, Harris SD, et al.

J Fungi (Basel). 2021 Jun 29;7(7):525. doi: 10.3390/jof7070525.

PMID: 34210108

Affinity precipitation of monoclonal antibodies using ELP-Z in the elution without resolubilization mode.

Bhat M, Mullerpatan A, Chen J, Holstein M, Ghose S, Li ZJ, Cramer S, et al.

J Biotechnol. 2021 Jun 29;338:1-4. doi: 10.1016/j.jbiotec.2021.06.020. Online ahead of print.

PMID: 34197822

Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients.

Boucher Y, Kumar AS, Posada JM, Gjini E, Pfaff K, Lipschitz M, Lako A, Duda DG, Rodig SJ, Hodi FS, Jain RK, et al.

NPJ Precis Oncol. 2021 Jun 29;5(1):62. doi: 10.1038/s41698-021-00197-w.

PMID: 34188163

Survival analysis for AdVerse events with VarYing follow-up times (SAVVY)-estimation of adverse event risks.

Stegherr R, Schmoor C, Beyersmann J, Rufibach K, Jehl V, Brückner A, Eisele L, Künzel T, Kupas K, Langer F, Leverkus F, Loos A, Norenberg C, Voss F, Friede T, et al.

Trials. 2021 Jun 29;22(1):420. doi: 10.1186/s13063-021-05354-x.

PMID: 34187527

Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic.

Etxeberria I, Bolaños E, Teijeira A, Garasa S, Yanguas A, Azpilikueta A, Kavanaugh WM, Vasiljeva O, Belvin M, Howng B, Irving B, Tipton K, West J, Mei L, Korman AJ, Sega E, Olivera I, Cirella A, Ochoa MC, Rodriguez ME, Melero A, Sanmamed MF, Engelhardt JJ, Melero I, et al.

Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2025930118. doi: 10.1073/pnas.2025930118.

PMID: 34172583

Cardiovascular Disease in Rheumatoid Arthritis: Risk Factors, Autoantibodies, and the Effect of Antirheumatic Therapies.

Fazeli MS, Khaychuk V, Wittstock K, Breznen B, Crocket G, Pourrahmat MM, Ferri L, et al.

Clin Med Insights Arthritis Musculoskelet Disord. 2021 Jun 28;14:11795441211028751. doi: 10.1177/11795441211028751. eCollection 2021.

PMID: 34262386

Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation.

Li BX, Kim DK, Bloom S, Huang RY, Qiao JX, Ewing WR, Oblinsky DG, Scholes GD, MacMillan DWC, et al.

Nat Chem. 2021 Jun 28. doi: 10.1038/s41557-021-00733-y. Online ahead of print.

PMID: 34183819

Genetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma.

Wall MA, Turkarslan S, Wu WJ, Danziger SA, Reiss DJ, Mason MJ, Dervan AP, Trotter MWB, Bassett D, Hershberg RM, Lomana ALG, Ratushny AV, Baliga NS, et al.

NPJ Precis Oncol. 2021 Jun 28;5(1):60. doi: 10.1038/s41698-021-00185-0.

PMID: 34183722

Flexible use of copula-type model for dose-finding in drug combination clinical trials.

Hashizume K, Tshuchida J, Sozu T, et al.

Biometrics. 2021 Jun 28. doi: 10.1111/biom.13510. Online ahead of print.

PMID: 34181760

A functional three-dimensional microphysiological human model of myeloma bone disease.

Visconti RJ, Kolaja K, Cottrell JA, et al.

J Bone Miner Res. 2021 Jun 25. doi: 10.1002/jbmr.4404. Online ahead of print.

PMID: 34173283

Optimized damping parameters for empirical dispersion corrections to symmetry-adapted perturbation theory.

Schriber JB, Sirianni DA, Smith DGA, Burns LA, Sitkoff D, Cheney DL, Sherrill CD, et al.

J Chem Phys. 2021 Jun 21;154(23):234107. doi: 10.1063/5.0049745.

PMID: 34241276

Current Status, Challenges, and Future Perspectives of Real-World Data and Real-World Evidence in Japan.

Hiramatsu K, Barrett A, Miyata Y; PhRMA Japan Medical Affairs Committee Working Group 1.

Drugs Real World Outcomes. 2021 Jun 19. doi: 10.1007/s40801-021-00266-3. Online ahead of print.

PMID: 34148219

KarMMa-RW: comparison of idecabtagene vicleucel with real-world outcomes in relapsed and refractory multiple myeloma.

Jagannath S, Lin Y, Goldschmidt H, Reece D, Nooka A, Senin A, Rodriguez-Otero P, Powles R, Matsue K, Shah N, Anderson LD Jr, Streetly M, Wilson K, Le HV, Swern AS, Agarwal A, Siegel DS, et al.

Blood Cancer J. 2021 Jun 18;11(6):116. doi: 10.1038/s41408-021-00507-2.

PMID: 34145225

Adapting preference-based utility measures to capture the impact of cancer treatment-related symptoms.

Shah KK, Bennett B, Lenny A, Longworth L, Brazier JE, Oppe M, Pickard AS, Shaw JW, et al.

Eur J Health Econ. 2021 Jun 17. doi: 10.1007/s10198-021-01337-6. Online ahead of print.

PMID: 34142266

Idecabtagene Vicleucel in Relapsed Myeloma. Reply.

Munshi NC, Hege K, San-Miguel J, et al.

N Engl J Med. 2021 Jun 17;384(24):2357-2358. doi: 10.1056/NEJMc2105069.

PMID: 34133871

Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.

Cherney EC, Zhang L, Guo W, Huang A, Williams D, Seitz S, Shan W, Zhu X, Gullo-Brown J, Maley D, Lin TA, Hunt JT, Huang C, Yang Z, D'Arienzo CJ, Discenza LN, Ranasinghe A, Grubb MF, Traeger SC, Li X, Johnston KA, Kopcho L, Fereshteh M, Foster KA, Stefanski K, Delpy D, Dhar G, Anandam A, Mahankali S, Padmanabhan S, Rajanna P, Murali V, Mariappan TT, Pattasseri S, Nimje RY, Hong Z, Kempson J, Rampulla R, Mathur A, Gupta A, Borzilleri R, Vite G, Balog A, et al.

ACS Med Chem Lett. 2021 Jun 16;12(7):1143-1150. doi: 10.1021/acsmedchemlett.1c00236. eCollection 2021 Jul 8.

PMID: 34267885

Late Relapse and Reinfection in HCV Patients Treated with Direct-Acting Antiviral (DAA) Drugs.

Minosse C, Gruber CEM, Rueca M, Taibi C, Zaccarelli M, Grilli E, Montalbano M, Capobianchi MR, Antinori A, D'Offizi G, McPhee F, Garbuglia AR, et al.

Viruses. 2021 Jun 16;13(6):1151. doi: 10.3390/v13061151.

PMID: 34208646

Retrospective Claims Analysis of Treatment Patterns, Relapse, Utilization, and Cost Among Patients with Multiple Sclerosis Initiating Second-Line Disease-Modifying Therapy.

Freeman L, Kee A, Tian M, Mehta R, et al.

Drugs Real World Outcomes. 2021 Jun 16. doi: 10.1007/s40801-021-00251-w. Online ahead of print.

PMID: 34136997

Effectiveness and safety of oral anticoagulation treatment beyond 1 year after venous thromboembolism in patients at intermediate recurrence risk.

Johnsen SP, Rasmussen TB, Falstie-Jensen AM, Harboe L, Stynes G, Dybro L, Hansen ML, Brandes A, Grove EL, Münster AM, et al.

Basic Clin Pharmacol Toxicol. 2021 Jun 15. doi: 10.1111/bcpt.13625. Online ahead of print.

PMID: 34128322

Advanced continuous-flow microfluidic device for parallel screening of crystal polymorphs, morphology, and kinetics at controlled supersaturation.

Coliaie P, Kelkar MS, Langston M, Liu C, Nazemifard N, Patience D, Skliar D, Nere NK, Singh MR, et al.

Lab Chip. 2021 Jun 15;21(12):2333-2342. doi: 10.1039/d1lc00218j.

PMID: 34096561

Cartesian message passing neural networks for directional properties: Fast and transferable atomic multipoles.

Glick ZL, Koutsoukas A, Cheney DL, Sherrill CD, et al.

J Chem Phys. 2021 Jun 14;154(22):224103. doi: 10.1063/5.0050444.

PMID: 34241239

Population Cellular Kinetics of Lisocabtagene Maraleucel, an Autologous CD19-Directed Chimeric Antigen Receptor T-Cell Product, in Patients with Relapsed/Refractory Large B-Cell Lymphoma.

Ogasawara K, Dodds M, Mack T, Lymp J, Dell'Aringa J, Smith J, et al.

Clin Pharmacokinet. 2021 Jun 14. doi: 10.1007/s40262-021-01039-5. Online ahead of print.

PMID: 34125421

Real-world analysis of patient characteristics, treatment outcomes, and healthcare resource utilization across Europe in patients with newly diagnosed multiple myeloma ineligible for stem cell transplantation who received lenalidomide- or bortezomib-based regimens.

Zamagni E, Dhanasiri S, Ghale A, Moore A, Roussel M, et al.

Leuk Lymphoma. 2021 Jun 14:1-10. doi: 10.1080/10428194.2021.1924369. Online ahead of print.

PMID: 34121589

Effectiveness and safety of apixaban, LMWH, and warfarin among high-risk subgroups of VTE patients with active cancer.

Cohen AT, Keshishian A, Lee T, Rosenblatt L, Hlavacek P, Sah J, Luo X, et al.

Curr Med Res Opin. 2021 Jun 14:1-16. doi: 10.1080/03007995.2021.1932448. Online ahead of print.

PMID: 34030541

General population normative data for the EQ-5D-3L in the five largest European economies.

Janssen MF, Pickard AS, Shaw JW, et al.

Eur J Health Econ. 2021 Jun 12. doi: 10.1007/s10198-021-01326-9. Online ahead of print.

PMID: 34117986

Pediatric soft tissue neoplasms with BRAF activating mutations.

Mochel MC, Wojcik JB, Gowda M, Tye GW, Patel RM, Smith SC, et al.

Mod Pathol. 2021 Jun 11. doi: 10.1038/s41379-021-00852-4. Online ahead of print.

PMID: 34117348

A practical response adaptive block randomization (RABR) design with analytic type I error protection.

Zhan T, Cui L, Geng Z, Zhang L, Gu Y, Chan ISF, et al.

Stat Med. 2021 Jun 10. doi: 10.1002/sim.9104. Online ahead of print.

PMID: 34111902

Telomerase Reverse Transcriptase Increases Proliferation and Lifespan of Human NK Cells without Immortalization.

Streltsova MA, Ustiuzhanina MO, Barsov EV, Kust SA, Velichinskii RA, Kovalenko EI, et al.

Biomedicines. 2021 Jun 9;9(6):662. doi: 10.3390/biomedicines9060662.

PMID: 34207853

Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus.

Xie JH, Zhang Y, Loubeau M, Mangan P, Heimrich E, Tovar C, Zhou X, Madia P, Doyle M, Dudhgaonkar S, Rudra A, Subramani S, Young J, Salter-Cid L, Malek TR, Struthers M, et al.

J Immunol. 2021 Jun 9:ji2100078. doi: 10.4049/jimmunol.2100078. Online ahead of print.

PMID: 34108258

Apremilast monotherapy for long-term treatment of active psoriatic arthritis in DMARD-naive patients.

Wells AF, Edwards CJ, Kivitz AJ, Bird P, Guerette B, Delev N, Paris M, Teng L, Aelion JA, et al.

Rheumatology (Oxford). 2021 Jun 8:keab449. doi: 10.1093/rheumatology/keab449. Online ahead of print.

PMID: 34100922

Blueprint for the discovery of biomarkers of toxicity and efficacy for CAR T cells and T-cell engagers.

Paczesny S, Pasquini MC, Pavletic SZ, Agarwal A, Spellman S, Kean L, Bernatchez C, Gust J, Staedtke V, Perales MA, et al.

Blood Adv. 2021 Jun 8;5(11):2519-2522. doi: 10.1182/bloodadvances.2021004604.

PMID: 34100901

Opalescence Measurements: Improvements in Fundamental Knowledge, Identifying Sources of Analytical Biases, and Advanced Applications for the Development of Therapeutic Proteins.

Barros M, Zhang X, Kenrick S, Valente JJ, et al.

J Pharm Sci. 2021 Jun 7:S0022-3549(21)00303-8. doi: 10.1016/j.xphs.2021.06.013. Online ahead of print.

PMID: 34111445

Real-world progression-free survival in first-line advanced non-small cell lung cancer treated with immunotherapy-based regimens using a US dataset.

Waterhouse D, Lam J, Betts KA, Yin L, Gao S, Yuan Y, Hartman J, Rao S, Lubinga S, Stenehjem D.

Data Brief. 2021 Jun 6;37:107195. doi: 10.1016/j.dib.2021.107195. eCollection 2021 Aug.

PMID: 34169127

Mimicking Low pH Virus Inactivation Used in Antibody Manufacturing Processes: Effect of Processing Conditions and Biophysical Properties on Antibody Aggregation and Particle Formation.

Kim NA, Kar S, Li Z, Das TK, Carpenter JF, et al.

J Pharm Sci. 2021 Jun 6:S0022-3549(21)00292-6. doi: 10.1016/j.xphs.2021.06.002. Online ahead of print.

PMID: 34090901

A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets.

Meruva S, Thool P, Gong Y, Agrawal A, Karki S, Bowen W, Mitra B, Kumar S, et al.

J Pharm Sci. 2021 Jun 5:S0022-3549(21)00290-2. doi: 10.1016/j.xphs.2021.05.025. Online ahead of print.

PMID: 34097976

Current challenges and opportunities for pharmacogenomics: perspective of the Industry Pharmacogenomics Working Group (I-PWG).

Bienfait K, Chhibber A, Marshall JC, Armstrong M, Cox C, Shaw PM, Paulding C, et al.

Hum Genet. 2021 Jun 3. doi: 10.1007/s00439-021-02282-3. Online ahead of print.

PMID: 34081195

Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.

Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD, et al.

N Engl J Med. 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442.

PMID: 34077643

Analytical Concordance of PD-L1 Assays Utilizing Antibodies From FDA-Approved Diagnostics in Advanced Cancers: A Systematic Literature Review.

Prince EA, Sanzari JK, Pandya D, Huron D, Edwards R, et al.

JCO Precis Oncol. 2021 Jun 8;5:953-973. doi: 10.1200/PO.20.00412. eCollection 2021 Jun.

PMID: 34136742

Editorial overview: Hot targets and new modalities.

Ciulli A, Wertz IE, et al.

Curr Opin Chem Biol. 2021 Jun;62:A1-A3. doi: 10.1016/j.cbpa.2021.04.010. Epub 2021 Jun 8.

PMID: 34116929

Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial.

Ferris RL, Spanos WC, Leidner R, Gonçalves A, Martens UM, Kyi C, Sharfman W, Chung CH, Devriese LA, Gauthier H, Chiosea SI, Vujanovic L, Taube JM, Stein JE, Li J, Li B, Chen T, Barrows A, Topalian SL, et al.

J Immunother Cancer. 2021 Jun;9(6):e002568. doi: 10.1136/jitc-2021-002568.

PMID: 34083421

Association Between Baseline Anti-cyclic Citrullinated Peptide Antibodies and 6-Month Clinical Response Following Abatacept or TNF Inhibitor Treatment: A Real-World Analysis of Biologic-Experienced Patients with RA.

Harrold LR, Bryson J, Lehman T, Zhuo J, Gao S, Han X, Schrader A, Rebello S, Pappas DA, Sommers T, Kremer JM, et al.

Rheumatol Ther. 2021 Jun;8(2):937-953. doi: 10.1007/s40744-021-00310-2. Epub 2021 May 28.

PMID: 34047953

The role of ligand-binding assay and LC-MS in the bioanalysis of complex protein and oligonucleotide therapeutics.

Kotapati S, Deshpande M, Jashnani A, Thakkar D, Xu H, Dollinger G, et al.

Bioanalysis. 2021 Jun;13(11):931-954. doi: 10.4155/bio-2021-0009. Epub 2021 May 17.

PMID: 33998268

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Spertus JA, Fine JT, Elliott P, Ho CY, Olivotto I, Saberi S, Li W, Dolan C, Reaney M, Sehnert AJ, Jacoby D, et al.

Lancet. 2021 Jun 26;397(10293):2467-2475. doi: 10.1016/S0140-6736(21)00763-7. Epub 2021 May 15.

PMID: 34004177

Critical review of oncology clinical trial design under non-proportional hazards.

Ananthakrishnan R, Green S, Previtali A, Liu R, Li D, LaValley M, et al.

Crit Rev Oncol Hematol. 2021 Jun;162:103350. doi: 10.1016/j.critrevonc.2021.103350. Epub 2021 May 12.

PMID: 33989767

Indirect Treatment Comparison of Liso-Cel vs. Salvage Chemotherapy in Diffuse Large B-Cell Lymphoma: TRANSCEND vs. SCHOLAR-1.

Salles G, Spin P, Liu FF, Garcia J, Kim Y, Hasskarl, et al.

J.Adv Ther. 2021 Jun;38(6):3266-3280. doi: 10.1007/s12325-021-01756-0. Epub 2021 May 10.

PMID: 33970454

Use of Non-Vitamin K Antagonist Oral Anticoagulants Among Patients with Nonvalvular Atrial Fibrillation and Multimorbidity.

Deitelzweig S, Keshishian A, Kang A, Dhamane AD, Luo X, Klem C, Rosenblatt L, Mardekian J, Jiang J, Yuce H, Lip GYH, et al.

Adv Ther. 2021 Jun;38(6):3166-3184. doi: 10.1007/s12325-021-01724-8. Epub 2021 May 7.

PMID: 33963511

Measuring the Value Healthy Individuals Place on Generous Insurance Coverage of Severe Diseases: A Stated Preference Survey of Adults Diagnosed With and Without Lung Cancer.

Shafrin J, May SG, Zhao LM, Bognar K, Yuan Y, Penrod JR, Romley JA.

Value Health. 2021 Jun;24(6):855-861. doi: 10.1016/j.jval.2020.06.021. Epub 2021 Mar 31.

PMID: 34119084

Qualitative analysis of actual Standard for Exchange of Nonclinical Data (SEND) datasets for Data Domains: Proposition from Japan Pharmaceutical Manufacturers Association SEND Taskforce Team on standardization of nonclinical data.

Sato G, Matsumoto I, Watanabe M, Kinomoto T, Nakajima M, Yamamoto M, Inoue Y, Kobayashi K, Tanaharu T, Kiya A, Yamaguchi T, Hayashi H, Motoyama K, Suzuki M, Watanabe K.

Regul Toxicol Pharmacol. 2021 Jun;122:104919. doi: 10.1016/j.yrtph.2021.104919. Epub 2021 Mar 20.

PMID: 33753112

Role of surface molecular environment and amorphous content in moisture sorption behavior of milled Terbutaline Sulphate.

Bagwan NUS, Sheokand S, Kaur A, Dubey G, Puri V, Bharatam PV, Bansal AK.

Eur J Pharm Sci. 2021 Jun 1;161:105782. doi: 10.1016/j.ejps.2021.105782. Epub 2021 Mar 3.

PMID: 33675911

Clinical and Economic Outcomes Among Nonvalvular Atrial Fibrillation Patients With Coronary Artery Disease and/or Peripheral Artery Disease.

Lopes RD, Thomas L, Di Fusco M, Keshishian A, Luo X, Li X, Masseria C, Friend K, Mardekian J, Pan X, Yuce H, Jones WS.

Am J Cardiol. 2021 Jun 1;148:69-77. doi: 10.1016/j.amjcard.2021.02.021. Epub 2021 Mar 3.

PMID: 33667438

Multimorbidity Accrual After Incident Rheumatoid Arthritis: A Wolf at the Door.

Sparks JA,

J Rheumatol. 2021 Jun 1:jrheum.210224. doi: 10.3899/jrheum.210224. Online ahead of print.

PMID: 34074680

Brachytherapy: Increased Use in Patients With Intermediate- and High-Risk Prostate Cancers.

Ali S, & Esper P.

Clin J Oncol Nurs. 2021 Jun 1;25(3):321-328. doi: 10.1188/21.CJON.321-328.

PMID: 34019017

Effectiveness and safety of nivolumab in patients with advanced melanoma: A multicenter, observational study.

Monestier S, Dalle S, Mortier L, Dutriaux C, Dalac-Rat S, Meyer N, Leccia MT, Mansard S, Montaudié H, Saiag P, Combemale P, Guillot B, Skowron F, Duval Modeste AB, Bénéton N, Hainaut E, Robert C, Arnault JP, Le Corre Y, Jouary T, Ameur N, Varey E, Khammari A, Dréno B; RIC-Mel network.

Int J Cancer. 2021 Jun 1;148(11):2789-2798. doi: 10.1002/ijc.33467. Epub 2021 Feb 19.

PMID: 33428772

Phase 2 Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors.

Fangusaro J, Cefalo MG, Garré ML, Marshall LV, Massimino M, Benettaib B, Biserna N, Poon J, Quan J, Conlin E, Lewandowski J, Simcock M, Jeste N, Hargrave DR, Doz F, Warren KE, et al.

Front Oncol. 2021 Jun 8;11:660892. doi: 10.3389/fonc.2021.660892. eCollection 2021.

PMID: 34168987

Disease Management and Outcomes in Patients Hospitalized for Acute Heart Failure in Japan.

Chen L, Ionescu-Ittu R, Romdhani H, Guerin A, Kessler P, Borentain M, Friend K, DeSouza M, Sato N, et al.

Cardiol Ther. 2021 Jun;10(1):211-228. doi: 10.1007/s40119-021-00212-y. Epub 2021 Feb 20.

PMID: 33609268

An Industry Perspective on the Challenges of Using Closed System Transfer Devices with Biologics and Communication Guidance to Healthcare Professionals.

Gopalrathnam G, Christian TR, Jagannathan B, Petoskey F, Kühnle B, Weiser S, Kagdi R, Saluja S, Bhattacharyya A, Burton L, Zamiri C, Hanley K, et al.

J Pharm Sci. 2021 Jun;110(6):2329-2335. doi: 10.1016/j.xphs.2021.02.008. Epub 2021 Feb 19.

PMID: 33617871

Harmonized 3Rs-based non-mutagenic impurity qualification study designs developed using the results of an IQ consortium survey.

Mitra MS, Datta K, Hutchinson R, Nicolette JJ, Pettersen JC, Wegesser TC, Bercu JP, et al.

Regul Toxicol Pharmacol. 2021 Jun;122:104895. doi: 10.1016/j.yrtph.2021.104895. Epub 2021 Feb 19.

PMID: 33610610

A custom ÄKTA avant configuration enabling automated parallel protein purification over a range of process scales.

Hollander C, Walrond SC, Connelly C, Megson L, Bove E, McDonagh T, et al.

Protein Expr Purif. 2021 Jun;182:105842. doi: 10.1016/j.pep.2021.105842. Epub 2021 Feb 11.

PMID: 33582289

Oral Anticoagulation Therapy for Venous Thromboembolism in Norway: Time Trends and Treatment Patterns.

Ghanima W, Schultze A, Donaldson R, Brodin E, Halvorsen S, Graham S, Carroll R, Ulvestad M, Lambrelli D, et al.

Clin Ther. 2021 May 31:S0149-2918(21)00212-5. doi: 10.1016/j.clinthera.2021.04.017. Online ahead of print.

PMID: 34083030

Long-term real-world experience with ipilimumab and non-ipilimumab therapies in advanced melanoma: the IMAGE study.

Dalle S, Mortier L, Corrie P, Lotem M, Board R, Arance AM, Meiss F, Terheyden P, Gutzmer R, Buysse B, Oh K, Brokaw J, Le TK, Mathias SD, Scotto J, Lord-Bessen J, Moshyk A, Kotapati S, Middleton MR, et al.

BMC Cancer. 2021 May 29;21(1):642. doi: 10.1186/s12885-021-08032-y.

PMID: 34051732

Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool.

Wang R, Ascanelli C, Abdelbaki A, Fung A, Rasmusson T, Michaelides I, Roberts K, Lindon C, et al.

Commun Biol. 2021 May 28;4(1):640. doi: 10.1038/s42003-021-02158-2.

PMID: 34050235

Identification of Novel, Immunogenic HLA-DR-Presented Prevotella copri Peptides in Patients with Rheumatoid Arthritis: Patients with Rheumatoid Arthritis.

Pianta A, Chiumento G, Ramsden K, Wang Q, Strle K, Arvikar S, Costello CE, Steere AC, et al.

Arthritis Rheumatol. 2021 May 27. doi: 10.1002/art.41807. Online ahead of print.

PMID: 34042327

Native mass spectrometry and gas-phase fragmentation provide rapid and in-depth topological characterization of a PROTAC ternary complex.

Song JH, Wagner ND, Yan J, Li J, Huang RY, Balog AJ, Newitt JA, Chen G, Gross ML, et al.

Cell Chem Biol. 2021 May 26:S2451-9456(21)00222-1. doi: 10.1016/j.chembiol.2021.05.005. Online ahead of print.

PMID: 34081921

CheckMate 040 cohort 5: A phase I/II study of nivolumab in patients with advanced hepatocellular carcinoma and Child-Pugh B cirrhosis.

Kudo M, Matilla A, Santoro A, Melero I, Gracián AC, Acosta-Rivera M, Choo SP, El-Khoueiry AB, Kuromatsu R, El-Rayes B, Numata K, Itoh Y, Di Costanzo F, Crysler O, Reig M, Shen Y, Neely J, Tschaika M, Wisniewski T, Sangro B, et al.

J Hepatol. 2021 May 26:S0168-8278(21)00313-5. doi: 10.1016/j.jhep.2021.04.047. Online ahead of print.

PMID: 34051329

Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.

Yang MG, Xiao Z, Zhao R, Tebben AJ, Wang B, Cherney RJ, Batt DG, Brown GD, Cvijic ME, Duncia JV, Gallela MA, Gardner DS, Khandelwal P, Malley MF, Pang J, Rose AV, Santella JB 3rd, Sarjeant AA, Xu S, Mathur A, Mandlekar S, Vuppugalla R, Zhao Q, Carter PH, et al.

ACS Med Chem Lett. 2021 May 25;12(6):969-975. doi: 10.1021/acsmedchemlett.1c00082. eCollection 2021 Jun 10.

PMID: 34141082

Detecting undiagnosed atrial fibrillation in UK primary care: Validation of a machine learning prediction algorithm in a retrospective cohort study.

Sekelj S, Sandler B, Johnston E, Pollock KG, Hill NR, Gordon J, Tsang C, Khan S, Ng FS, Farooqui U, et al.

Eur J Prev Cardiol. 2021 May 22;28(6):598-605. doi: 10.1177/2047487320942338.

PMID: 34021576

Postinfusion monitoring costs by site of care for patients with relapsed/refractory large B-cell lymphoma receiving third- or later-line treatment with lisocabtagene maraleucel in the TRANSCEND NHL 001 and OUTREACH trials.

Palomba ML, Jun MP, Lymp J, Nguyen A, McGarvey N, Gitlin M, Pelletier C, Keating SJ, Godwin J, et al.

Leuk Lymphoma. 2021 May 21:1-8. doi: 10.1080/10428194.2021.1910686. Online ahead of print.

PMID: 34018458

Myeloma NK cells are exhausted and have impaired regulation of activation.

D'Souza C, Keam SP, Yeang HXA, Neeson M, Richardson K, Hsu AK, Canfield R, Bezman N, Robbins M, Quach H, Ritchie DS, Harrison SJ, Trapani JA, Prince HM, Beavis PA, Darcy PK, Neeson PJ, et al.

Haematologica. 2021 May 20. doi: 10.3324/haematol.2020.277525. Online ahead of print.

PMID: 34011135

Persistence with Early-Line Abatacept versus Tumor Necrosis Factor-Inhibitors for Rheumatoid Arthritis Complicated by Poor Prognostic Factors.

Han X, Lobo F, Broder MS, Chang E, Gibbs SN, Ridley DJ, Yermilov I.

J Health Econ Outcomes Res. 2021 May 19;8(1):71-78. doi: 10.36469/jheor.2021.23684.

PMID: 34046511

Efficacy and Safety of Durvalumab Combined with Daratumumab in Daratumumab-Refractory Multiple Myeloma Patients.

Frerichs KA, Verkleij CPM, Dimopoulos MA, Marin Soto JA, Zweegman S, Young MH, Newhall KJ, Mutis T, van de Donk NWCJ, et al.

Cancers (Basel). 2021 May 18;13(10):2452. doi: 10.3390/cancers13102452.

PMID: 34070044

Exploring the Role of Surfactants in Enhancing Drug Release from Amorphous Solid Dispersions at Higher Drug Loadings.

Saboo S, Bapat P, Moseson DE, Kestur US, Taylor LS, et al.

Pharmaceutics. 2021 May 17;13(5):735. doi: 10.3390/pharmaceutics13050735.

PMID: 34067666

Toluidine blue staining of murine mast cells and quantitation by a novel, automated image analysis method using whole slide skin images.

Raja N, Naikodi S, Govindarajan A, Palanisamy K, et al.

J Histotechnol. 2021 May 17:1-6. doi: 10.1080/01478885.2021.1915934. Online ahead of print.

PMID: 33998401

Safety and Effectiveness of Apixaban in Japanese Patients With Venous Thromboembolism in Clinical Practice　- A Post-Marketing Surveillance.

Yamada N, Mo M, Ohsawa A, Sato M, Umeyama M, Shima D, Nakamura M, et al.

Circ J. 2021 May 15. doi: 10.1253/circj.CJ-20-0829. Online ahead of print.

PMID: 33994408

Gastrointestinal Adverse Drug Reaction Profile of Etanercept: Real-world Data From Patients and Healthcare Professionals.

van Lint JA, Jessurun NT, Tas SW, van den Bemt BJF, Nurmohamed MT, van Doorn MBA, Spuls PI, van Tubergen AM, Ten Klooster PM, van Puijenbroek EP, Hoentjen F, Vonkeman HE, et al.

J Rheumatol. 2021 May 15:jrheum.201373. doi: 10.3899/jrheum.201373. Online ahead of print.

PMID: 33993115

Canadian Rheumatologists' Perspectives on Moderate Psoriatic Arthritis and Oligoarticular Psoriatic Arthritis.

Gladman DD, Starr M, Cividino A, Gaudreau AJ, Jelley J, Nicholson D, Karsh J, et al.

J Rheumatol. 2021 May 15:jrheum.201195. doi: 10.3899/jrheum.201195. Online ahead of print.

PMID: 33993114

SCLIFF: A component-based, machine-learned, intermolecular force field.

Schriber JB, Nascimento DR, Koutsoukas A, Spronk SA, Cheney DL, Sherrill CD, et al.

J Chem Phys. 2021 May 14;154(18):184110. doi: 10.1063/5.0042989.

PMID: 34241025

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors.

Xu L, Hartz RA, Beno BR, Ghosh K, Shukla JK, Kumar A, Patel D, Kalidindi N, Lemos N, Gautam SS, Kumar A, Ellsworth BA, Shah D, Sale H, Cheng D, Regueiro-Ren A, et al.

J Med Chem. 2021 May 27;64(10):6634-6655. doi: 10.1021/acs.jmedchem.0c02001. Epub 2021 May 14.

PMID: 33988358

Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells.

Han Z, Ma Y, Cao G, Ma Z, Chen R, Cvijic ME, Cheng D, et al.

Biochem J. 2021 May 14;478(9):1689-1703. doi: 10.1042/BCJ20200749.

PMID: 33876829

Clinical Relevance of Torque Teno Virus (TTV) in HIV/HCV Coinfected and HCV Monoinfected Patients Treated with Direct-Acting Antiviral Therapy.

Lapa D, Del Porto P, Minosse C, D'Offizi G, Antinori A, Capobianchi MR, Visco-Comandini U, McPhee F, Garbuglia AR, Zaccarelli M, et al.

J Clin Med. 2021 May 13;10(10):2092. doi: 10.3390/jcm10102092.

PMID: 34068071

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis.

Selvaraj EA, Mózes FE, Jayaswal ANA, Zafarmand MH, Vali Y, Lee JA, Levick CK, Young LAJ, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators.

J Hepatol. 2021 May 13:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. Online ahead of print.

PMID: 33991635

N-Ammonium Ylide Mediators for Electrochemical C-H Oxidation.

Saito M, Kawamata Y, Meanwell M, Navratil R, Chiodi D, Carlson E, Hu P, Chen L, Udyavara S, Kingston C, Tanwar M, Tyagi S, McKillican BP, Gichinga MG, Schmidt MA, Eastgate MD, Lamberto M, He C, Tang T, Malapit CA, Sigman MS, Minteer SD, Neurock M, Baran PS, et al.

J Am Chem Soc. 2021 May 26;143(20):7859-7867. doi: 10.1021/jacs.1c03780. Epub 2021 May 13.

PMID: 33983721

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration.

Wang H, Brown PC, Chow ECY, Ewart L, Ferguson SS, Fitzpatrick S, Freedman BS, Guo GL, Hedrich W, Heyward S, Hickman J, Isoherranen N, Li AP, Liu Q, Mumenthaler SM, Polli J, Proctor WR, Ribeiro A, Wang JY, Wange RL, Huang SM, et al.

Clin Transl Sci. 2021 May 13. doi: 10.1111/cts.13066. Online ahead of print.

PMID: 33982436

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia.

Wang F, Morita K, DiNardo CD, Furudate K, Tanaka T, Yan Y, Patel KP, MacBeth KJ, Wu B, Liu G, Frattini M, Matthews JA, Little LD, Gumbs C, Song X, Zhang J, Thompson EJ, Kadia TM, Garcia-Manero G, Jabbour E, Ravandi F, Bhalla KN, Konopleva M, Kantarjian HM, Andrew Futreal P, Takahashi K, et al.

Nat Commun. 2021 May 10;12(1):2607. doi: 10.1038/s41467-021-22874-x.

PMID: 33972549

Evaluation of fully-functionalized diazirine tags for chemical proteomic applications.

Conway LP, Jadhav AM, Homan RA, Li W, Rubiano JS, Hawkins R, Lawrence RM, Parker CG, et al.

Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.

PMID: 34168837

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource.

Iwaki H, Leonard HL, Makarious MB, Bookman M, Landin B, Vismer D, Casey B, Gibbs JR, Hernandez DG, Blauwendraat C, Vitale D, Song Y, Kumar D, Dalgard CL, Sadeghi M, Dong X, Misquitta L, Scholz SW, Scherzer CR, Nalls MA, Biswas S, Singleton AB; Uniformed Services University of the Health Sciences Associates; AMP PD Whole Genome Sequencing Working Group; AMP PD consortium.

Mov Disord. 2021 May 7. doi: 10.1002/mds.28549. Online ahead of print.

PMID: 33960523

Trends in the prescription of systemic anticancer therapy and mortality among patients with advanced non-small cell lung cancer: a real-world retrospective observational cohort study from the I-O optimise initiative.

Snee M, Cheeseman S, Thompson M, Riaz M, Sopwith W, Lacoin L, Chaib C, Manley Daumont M, Penrod JR, O'Donnell JC, Hall G, et al.

BMJ Open. 2021 May 3;11(5):e043442. doi: 10.1136/bmjopen-2020-043442.

PMID: 33941627

Dental nurse role in operatory during and post pandemic outbreak of COVID-19.

Sajja R.

J Family Med Prim Care. 2021 May;10(5):2047. doi: 10.4103/jfmpc.jfmpc_2229_20. Epub 2021 May 31.

PMID: 34195149

Evaluation of vanillin as a probe drug for aldehyde oxidase and phenotyping for its activity in a Western Indian Cohort.

Subash S, Gogtay NJ, Iyer KR, Gandhe P, Budania R, Thatte UM, et al.

Indian J Pharmacol. 2021 May-Jun;53(3):213-220. doi: 10.4103/ijp.IJP_463_18.

PMID: 34169906

Improved efficacy/safety profile of factor XIa inhibitor BMS-724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys.

Wong PC and Quan ML.

Res Pract Thromb Haemost. 2021 May 28;5(4):e12524. doi: 10.1002/rth2.12524. eCollection 2021 May.

PMID: 34095733

The impact of ligand binding based assays critical reagent characterization and storage.

Haulenbeek J and Beaver CJ.

Bioanalysis. 2021 May;13(10):797-805. doi: 10.4155/bio-2020-0288. Epub 2021 May 18.

PMID: 34002637

Context matters in CAR T cell tonic signaling.

Hege K.

Nat Med. 2021 May;27(5):763-764. doi: 10.1038/s41591-021-01340-7.

PMID: 33972792

Calibrator material selection: a key criteria during biomarker assay method development.

Thankamony SP, Liu R, Peterson JE, Santockyte R, Olah T, Zhang Y, et al.

Bioanalysis. 2021 May;13(10):787-796. doi: 10.4155/bio-2020-0208. Epub 2021 May 7.

PMID: 33960820

Pain in Axial Spondyloarthritis: More to It Than Just Inflammation.

Magrey MN, Mease PJ, et al.

J Rheumatol. 2021 May 1:jrheum.210137. doi: 10.3899/jrheum.210137. Online ahead of print.

PMID: 33934079

Pooled Safety Results Through One Year of Two Phase-3 Trials of Guselkumab in Patients with Psoriatic Arthritis.

Rahman P, Ritchlin CT, Helliwell PS, Boehncke WH, Mease PJ, Gottlieb AB, Kafka S, Kollmeier AP, Hsia EC, Xu XL, Shawi M, Sheng S, Agarwal P, Zhou B, Ramachandran P, Zhuang Y, McInnes IB, et al.

J Rheumatol. 2021 May 1:jrheum.201532. doi: 10.3899/jrheum.201532. Online ahead of print.

PMID: 33934076

Predicting Response to Tocilizumab Monotherapy in Rheumatoid Arthritis: A Real-world Data Analysis Using Machine Learning.

Johansson FD, Collins JE, Yau V, Guan H, Kim SC, Losina E, Sontag D, Stratton J, Trinh H, Greenberg J, Solomon DH, et al.

J Rheumatol. 2021 May 1:jrheum.201626. doi: 10.3899/jrheum.201626. Online ahead of print.

PMID: 33934070

SCAMP3 is a mutant EGFR phosphorylation target and a tumor suppressor in lung adenocarcinoma.

Venugopalan A, Lynberg M, Cultraro CM, Nguyen KDP, Zhang X, Waris M, Dayal N, Abebe A, Maity TK, Guha U, et al.

Oncogene. 2021 May;40(18):3331-3346. doi: 10.1038/s41388-021-01764-y. Epub 2021 Apr 13.

PMID: 33850265

Genome-wide enhancer maps link risk variants to disease genes.

Nasser J, Bergman DT, Fulco CP, Guckelberger P, Doughty BR, Patwardhan TA, Jones TR, Nguyen TH, Ulirsch JC, Lekschas F, Mualim K, Natri HM, Weeks EM, Munson G, Kane M, Kang HY, Cui A, Ray JP, Eisenhaure TM, Collins RL, Dey K, Pfister H, Price AL, Epstein CB, Kundaje A, Xavier RJ, Daly MJ, Huang H, Finucane HK, Hacohen N, Lander ES, Engreitz JM, et al.

Nature. 2021 May;593(7858):238-243. doi: 10.1038/s41586-021-03446-x. Epub 2021 Apr 7.

PMID: 33828297

United States Utility Algorithm for the EORTC QLU-C10D, a Multiattribute Utility Instrument Based on a Cancer-Specific Quality-of-Life Instrument.

Revicki DA, King MT, Viney R, Pickard AS, Mercieca-Bebber R, Shaw JW, Müller F, Norman R, et al.

Med Decis Making. 2021 May;41(4):485-501. doi: 10.1177/0272989X211003569. Epub 2021 Apr 5.

PMID: 33813946

Novel techniques and the new age of biomarkers: panel discussion report.

Pasas-Farmer S, James C, Fandozzi C, Warrino D, Durham R, Hayes R, Cape S, Olah T.

Bioanalysis. 2021 May;13(9):675-678. doi: 10.4155/bio-2021-0049. Epub 2021 Mar 26.

PMID: 33769091

Phase III, Randomized, Placebo-Controlled Trial of CC-486 (Oral Azacitidine) in Patients With Lower-Risk Myelodysplastic Syndromes.

Garcia-Manero G, Santini V, Almeida A, Platzbecker U, Jonasova A, Silverman LR, Falantes J, Reda G, Buccisano F, Fenaux P, Buckstein R, Diez Campelo M, Larsen S, Valcarcel D, Vyas P, Giai V, Olíva EN, Shortt J, Niederwieser D, Mittelman M, Fianchi L, La Torre I, Zhong J, Laille E, Lopes de Menezes D, Skikne B, Beach CL, Giagounidis A.

J Clin Oncol. 2021 May 1;39(13):1426-1436. doi: 10.1200/JCO.20.02619. Epub 2021 Mar 25.

PMID: 33764805

Low-density lipoprotein cholesterol lowering in real-world patients treated with evolocumab.

Desai NR, Wade RL, Xiang P, Pinto L, Nunna S, Wang X, Exter J, Mues KE, Habib M, Chen CC.

Clin Cardiol. 2021 May;44(5):715-722. doi: 10.1002/clc.23600. Epub 2021 Mar 24.

PMID: 33760276

Evaluation of a polysaccharide-based chiral reversed-phase liquid chromatography screen strategy in pharmaceutical analysis.

Lin Z, Tai HC, Zhu G, Fabiano A, Borges-Muñoz A, Ye YK, He BL.

J Chromatogr A. 2021 May 24;1645:462085. doi: 10.1016/j.chroma.2021.462085. Epub 2021 Mar 22.

PMID: 33848654

Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies.

Renneville A, Gasser JA, Grinshpun DE, Jean Beltran PM, Udeshi ND, Matyskiela ME, Clayton T, McConkey M, Viswanathan K, Tepper A, Guirguis AA, Sellar RS, Cotteret S, Marzac C, Saada V, De Botton S, Kiladjian JJ, Cayuela JM, Rolfe M, Chamberlain PP, Carr SA, Ebert BL.

Blood Cancer Discov. 2021 May;2(3):250-265. doi: 10.1158/2643-3230.bcd-20-0105. Epub 2021 Mar 10.

PMID: 34027417

Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator.

Surapaneni S, Yerramilli U, Bai A, Dalvie D, Brooks J, Wang X, Selkirk JV, Yan YG, Zhang P, Hargreaves R, Kumar G, Palmisano M, Tran JQ.

Drug Metab Dispos. 2021 May;49(5):405-419. doi: 10.1124/dmd.120.000220. Epub 2021 Mar 4.

PMID: 33674268

A Metal-Free Reductive N-Alkylation of Indoles with Aldehydes.

Clanton NA, Spiller TE, Ortiz E, Gao Z, Rodriguez-Poirier JM, DelMonte AJ, Frantz DE, et al.

Org Lett. 2021 May 7;23(9):3233-3236. doi: 10.1021/acs.orglett.1c00179. Epub 2021 Feb 25.

PMID: 33630601

Response-adaptive trial designs with accelerated Thompson sampling.

Wang J.

Pharm Stat. 2021 May;20(3):645-656. doi: 10.1002/pst.2098. Epub 2021 Feb 14.

PMID: 33586310

Development of HPLC-CAD stability indicating assay method for polyethylene glycol-conjugated phospholipid (DMPE-PEG 2000) and identification of its degradation products.

Kurmi M, Suryavanshi V, Panduranga NS, Jayaraman K, Bajpai L, Fish W, Hu Y, Bhutani H, et al.

J Pharm Biomed Anal. 2021 May 10;198:113967. doi: 10.1016/j.jpba.2021.113967. Epub 2021 Feb 12.

PMID: 33662758

Continuing to Broaden Eligibility Criteria to Make Clinical Trials More Representative and Inclusive: ASCO-Friends of Cancer Research Joint Research Statement.

Kim ES, Uldrick TS, Schenkel C, Bruinooge SS, Harvey RD, Magnuson A, Spira A, Wade JL, Stewart MD, Vega DM, Beaver JA, Denicoff AM, Ison G, Ivy SP, George S, Perez RP, Spears PA, Tap WD, Schilsky RL, et al.

Clin Cancer Res. 2021 May 1;27(9):2394-2399. doi: 10.1158/1078-0432.CCR-20-3852. Epub 2021 Feb 9.

PMID: 33563632

Second-line nivolumab in relapsed small-cell lung cancer: CheckMate 331^☆.

Spigel DR, Vicente D, Ciuleanu TE, Gettinger S, Peters S, Horn L, Audigier-Valette C, Pardo Aranda N, Juan-Vidal O, Cheng Y, Zhang H, Shi M, Luft A, Wolf J, Antonia S, Nakagawa K, Fairchild J, Baudelet C, Pandya D, Doshi P, Chang H, Reck M, et al.

Ann Oncol. 2021 May;32(5):631-641. doi: 10.1016/j.annonc.2021.01.071. Epub 2021 Feb 1.

PMID: 33539946

A Study Comparing Patient and Clinician Perspectives of Treatments for Multiple Sclerosis via Group Concept Mapping.

Singer BA, Keith S, Howerter A, Doll H, Pham T, Mehta R, et al.

Patient Prefer Adherence. 2021 May 12;15:975-987. doi: 10.2147/PPA.S297052. eCollection 2021.

PMID: 34012257

Association of Morbid Progression With Overall Survival Among Patients With Multiple Myeloma: Validation of the Progression-free Survival Endpoint.

Rosenberg AS, Facon T, Parikh K, Chung W, Srinivasan S, Kotey S, Tuscano J, et al.

Clin Lymphoma Myeloma Leuk. 2021 May;21(5):345-354.e4. doi: 10.1016/j.clml.2020.12.021. Epub 2020 Dec 27.

PMID: 33563582

Correction to: Effectiveness and safety of nivolumab in patients with head and neck cancer in Japanese real‑world clinical practice: a multicentre retrospective clinical study.

Hanai N, Shimizu Y, Kariya S, Yasumatsu R, Yokota T, Fujii T, Tsukahara K, Yoshida M, Hanyu K, Ueda T, Hirakawa H, Takahashi S, Ono T, Sano D, Yamauchi M, Watanabe A, Omori K, Yamazaki T, Monden N, Kudo N, Arai M, Sakurai D, Asakage T, Doi I, Yamada T, Homma A, et al.

Int J Clin Oncol. 2021 May;26(5):1005-1006. doi: 10.1007/s10147-021-01879-y.

PMID: 33837490

Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19.

Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, Soma VL, Maddux AB, Mourani PM, Bowens C, Maamari M, Hall MW, Riggs BJ, Giuliano JS Jr, Singh AR, Li S, Kong M, Schuster JE, McLaughlin GE, Schwartz SP, Walker TC, Loftis LL, Hobbs CV, Halasa NB, Doymaz S, Babbitt CJ, Hume JR, Gertz SJ, Irby K, Clouser KN, Cvijanovich NZ, Bradford TT, Smith LS, Heidemann SM, Zackai SP, Wellnitz K, Nofziger RA, Horwitz SM, Carroll RW, Rowan CM, Tarquinio KM, Mack EH, Fitzgerald JC, Coates BM, Jackson AM, Young CC, Son MBF, Patel MM, Newburger JW, Randolph AG; Overcoming COVID-19 Investigators.

JAMA. 2021 Mar 16;325(11):1074-1087. doi: 10.1001/jama.2021.2091.

PMID: 33625505

Psoriasis and Psoriatic Arthritis in the Context of the COVID-19 Pandemic: A Plenary Session From the GRAPPA 2020 Annual Meeting.

Mease PJ, Calabrese LH, Callis Duffin K, Haberman RH, Firmino R, Scher JU, Schick L, Winthrop K, Merola JF.

J Rheumatol. 2021 Mar 15:jrheum.201671. doi: 10.3899/jrheum.201671. Online ahead of print.

PMID: 33722951

Pustular Psoriasis and Associated Musculoskeletal Disorders.

Callis Duffin K, Bachelez H, Mease PJ, Rosen C, Garg A, Zudak E, Elkayam O, Merola J, Chau J, Kishimoto M, Furer V, Helliwell PS.

J Rheumatol. 2021 Mar 15:jrheum.201673. doi: 10.3899/jrheum.201673. Online ahead of print.

PMID: 33722939

Recommendations on eliminating racial disparities in multiple myeloma therapies: a step toward achieving equity in healthcare.

Gormley N, Fashoyin-Aje L, Locke T, Unger J, Little RF, Nooka A, Mezzi K, Popa-McKiver M, Kobos R, Biru Y, Williams TH, Anderson KC.

Blood Cancer Discov. 2021 Mar;2(2):119-124. doi: 10.1158/2643-3230.bcd-20-0123.

PMID: 34179821

Methodological considerations for measuring biofluid-based microRNA biomarkers.

Chorley BN, Atabakhsh E, Doran G, Gautier JC, Ellinger-Ziegelbauer H, Jackson D, Sharapova T, Yuen PST, Church RJ, Couttet P, Froetschl R, McDuffie J, Martinez V, Pande P, Peel L, Rafferty C, Simutis FJ, Harrill AH.

Crit Rev Toxicol. 2021 Mar;51(3):264-282. doi: 10.1080/10408444.2021.1907530. Epub 2021 May 26.

PMID: 34038674

Composite Measures for Routine Clinical Practice in Psoriatic Arthritis: Testing of Shortened Versions in a UK Multicenter Study.

Tillett W, FitzGerald O, Coates LC, Packham J, Jadon DR, Massarotti M, Brook M, Lane S, Creamer P, Antony A, Korendowych E, Rambojun A, McHugh NJ, Helliwell PS; on behalf of the PROMPT Study Group.

J Rheumatol. 2021 Mar 1:jrheum.201675. doi: 10.3899/jrheum.201675. Online ahead of print.

PMID: 33649075

Composite Measures for Clinical Trials in Psoriatic Arthritis: Testing Pain and Fatigue Modifications in a UK Multicenter Study.

Tillett W, FitzGerald O, Coates LC, Packham J, Jadon DR, Massarotti M, Brook M, Lane S, Creamer P, Antony A, Korendowych E, Rambojun A, McHugh NJ, Helliwell PS; PROMPT Study Group.

J Rheumatol. 2021 Mar 1:jrheum.201674. doi: 10.3899/jrheum.201674. Online ahead of print.

PMID: 33649073

Effectiveness of a Second Biologic After Failure of a Non-tumor Necrosis Factor Inhibitor As First Biologic in Rheumatoid Arthritis.

Chatzidionysiou K, Hetland ML, Frisell T, Di Giuseppe D, Hellgren K, Glintborg B, Nordström D, Peltomaa R, Aaltonen K, Trokovic N, Kristianslund EK, Kvien TK, Provan SA, Gudbjornsson B, Grondal G, Dreyer L, Kristensen LE, Jørgensen TS, Jacobsson LTH, Askling J, et al.

J Rheumatol. 2021 Mar 1:jrheum.201467. doi: 10.3899/jrheum.201467. Online ahead of print.

PMID: 33649069

Updates on Axial Psoriatic Arthritis From the 2020 GRAPPA Annual Meeting.

Gladman DD, Helliwell PS, Poddubnyy D, Mease PJ, et al.

J Rheumatol. 2021 Mar 1:jrheum.201672. doi: 10.3899/jrheum.201672. Online ahead of print.

PMID: 33649067

Treatment and outcomes for early non-small-cell lung cancer: a retrospective analysis of a Portuguese hospital database.

Soares M, Antunes L, Redondo P, Borges M, Hermans R, Patel D, Grimson F, Munro R, Chaib C, Lacoin L, Daumont M, Penrod JR, O'Donnell JC, Bento MJ, Gonçalves FR, et al.

Lung Cancer Manag. 2021 Feb 19;10(2):LMT46. doi: 10.2217/lmt-2020-0028.

PMID: 34084212

Proceedings of the 2020 GRAPPA Collaborative Research Network (CRN) Meeting.

Stober C, Jadon DR, Armstrong AW, Chandran V, de Wit M, Helliwell PS, Mease P, Ogdie A, O'Sullivan D, Pennington SR, Löve T, Cauli A, van Mens L, Waxman R, Scher JU, Barton A, Ritchlin CT, FitzGerald O, et al.

J Rheumatol. 2021 Feb 15:jrheum.201667. doi: 10.3899/jrheum.201667. Online ahead of print.

PMID: 33589562

GRAPPA 2020 Update From the Education Committee.

Mease PJ, Garg A, Helliwell PS; GRAPPA Education Committee.

J Rheumatol. 2021 Feb 15:jrheum.201678. doi: 10.3899/jrheum.201678. Online ahead of print.

PMID: 33589560

Diagnostic Delay in Psoriatic Arthritis: A Population-based Study.

Karmacharya P, Wright K, Achenbach SJ, Bekele D, Crowson CS, Ogdie A, Duarte-García A, Ernste FC, Tollefson MM, Davis JM 3rd.

J Rheumatol. 2021 Feb 15:jrheum.201199. doi: 10.3899/jrheum.201199. Online ahead of print.

PMID: 33589556

Prologue: 2020 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).

Callis Duffin K, Gottlieb AB, O'Sullivan D, Gladman DD, McFarland LV, et al.

J Rheumatol. 2021 Feb 15:jrheum.201666. doi: 10.3899/jrheum.201666. Online ahead of print.

PMID: 33589551

GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting.

Coates LC, Corp N, van der Windt DA, Soriano ER, Kavanaugh A, et al.

J Rheumatol. 2021 Feb 15:jrheum.201681. doi: 10.3899/jrheum.201681. Online ahead of print.

PMID: 33589547

Overview of the Grant Writing Workshop From the GRAPPA 2020 Annual Meeting.

Ogdie A and Ritchlin CT.

J Rheumatol. 2021 Feb 15:jrheum.201669. doi: 10.3899/jrheum.201669. Online ahead of print.

PMID: 33589545

Disappearance of MMR-deficient subclones after controlled IL-12 and PD-1 inhibition in a glioma patient.

McCord M, Lukas RV, Amidei C, Demars N, Gelb A, Buck J, Sachdev S, Feldman A, Tate M, Dixit K, Brat DJ, Jennings L, Horbinski C, et al.

Neurooncol Adv. 2021 Mar 15;3(1):vdab045. doi: 10.1093/noajnl/vdab045. eCollection 2021 Jan-Dec.

PMID: 34250480

Follicular lymphoma dynamics.

Milpied P, Gandhi AK, Cartron G, Pasqualucci L, Tarte K, Nadel B, Roulland S, et al.

Adv Immunol. 2021;150:43-103. doi: 10.1016/bs.ai.2021.05.002. Epub 2021 Jun 18.

PMID: 34176559

Real-world treatment patterns, healthcare use and costs in triple-class exposed relapsed and refractory multiple myeloma patients in the USA.

Madduri D, Hagiwara M, Parikh K, Pelletier C, Delea TE, Kee A, Chari A, et al.

Future Oncol. 2021 Feb;17(5):503-515. doi: 10.2217/fon-2020-1003. Epub 2020 Dec 2.

PMID: 33522834

Application of First Principles Primary Drying Model to Lyophilization Process Design and Transfer: Case Studies From the Industry.

Tchessalov S, Latshaw D 2nd, Nulu S, Bentley M, Tharp T, Ewan S, Chen X, et al.

J Pharm Sci. 2021 Feb;110(2):968-981. doi: 10.1016/j.xphs.2020.11.013. Epub 2020 Nov 26.

PMID: 33248058

Effects of a Novel Nitroxyl Donor in Acute Heart Failure: The STAND-UP AHF Study.

Felker GM, McMurray JJV, Cleland JG, O'Connor CM, Teerlink JR, Voors AA, Belohlavek J, Böhm M, Borentain M, Bueno H, Cole RT, DeSouza MM, Ezekowitz JA, Filippatos G, Lang NN, Kessler PD, Martinez FA, Mebazaa A, Metra M, Mosterd A, Pang PS, Ponikowski P, Sato N, Seiffert D, Ye J, et al.

JACC Heart Fail. 2021 Feb;9(2):146-157. doi: 10.1016/j.jchf.2020.10.012. Epub 2020 Nov 25.

PMID: 33248986

Enabling direct and definitive free fraction determination for highly-bound compounds in protein binding assay.

Zhang J, Pikul G, Horch J, Konovalov D, Li S, Cvijic ME, Shou W, Weller H, et al.

J Pharm Biomed Anal. 2021 Feb 5;194:113765. doi: 10.1016/j.jpba.2020.113765. Epub 2020 Nov 20.

PMID: 33272788

Industry experiences with immune-mediated findings in biotherapeutic nonclinical toxicology studies.

MacLachlan TK, Kronenberg S, Marshall N, Andrews L, Berens SJ, Brouta F, Fogal B, Freebern W, Herzyk D, Kamperschroer C, Kiessling A, Schneidkraut M, Maier C, et al.

Regul Toxicol Pharmacol. 2021 Feb;119:104825. doi: 10.1016/j.yrtph.2020.104825. Epub 2020 Nov 19.

PMID: 33220389

Scientific Best Practices for Primary Sequence Confirmation and Sequence Variant Analysis in the Development of Therapeutic Proteins.

Lund A, Ren D, Rogers RS, Rouse JC, Yu XC, Valliere-Douglass JF, et al.

J Pharm Sci. 2021 Feb;110(2):619-626. doi: 10.1016/j.xphs.2020.11.007. Epub 2020 Nov 17.

PMID: 33212163

Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy.

Grillo MP, Markova S, Evanchik M, Trellu M, Moliner P, Brun P, Perreard-Dumaine A, Vicat P, Driscoll JP, Carlson TJ, et al.

Xenobiotica. 2021 Feb;51(2):222-238. doi: 10.1080/00498254.2020.1839982. Epub 2020 Nov 16.

PMID: 33078965

The performance, reliability and potential application of in silico models for predicting the acute oral toxicity of pharmaceutical compounds.

Graham JC, Rodas M, Hillegass J, Schulze G, et al.

Regul Toxicol Pharmacol. 2021 Feb;119:104816. doi: 10.1016/j.yrtph.2020.104816. Epub 2020 Nov 6.

PMID: 33166621

Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.

Kumar V, Yin M, Ishida K, Salphati L, Hop CECA, Rowbottom C, Xiao G, Lai Y, Mathias A, Chu X, Humphreys WG, Liao M, Nerada Z, Szilvásy N, Heyward S, Unadkat JD, et al.

Drug Metab Dispos. 2021 Feb;49(2):159-168. doi: 10.1124/dmd.120.000204. Epub 2020 Oct 13.

PMID: 33051248

Acoustic Ejection/Full-Scan Mass Spectrometry Analysis for High-Throughput Compound Quality Control.

Zhang J, Zhang Y, Liu C, Covey T, Nielsen J, Li S, Weller H, Shou W, et al.

SLAS Technol. 2021 Apr;26(2):178-188. doi: 10.1177/2472630320967625. Epub 2020 Nov 16.

PMID: 33196338

Selectivity in the Elaboration of Bicyclic Borazarenes.

Bhattacharjee A, Davies GHM, Saeednia B, Wisniewski SR, Molander GA, et al.

Adv Synth Catal. 2021 Apr 27;363(9):2256-2273. doi: 10.1002/adsc.202001384. Epub 2020 Dec 23.

PMID: 34335130

Pharmacokinetics of Voxelotor in Patients With Renal and Hepatic Impairment.

Preston RA, Marbury T, Balaratnam G, Green M, Dixon S, Lehrer-Graiwer J, Washington C, et al.

J Clin Pharmacol. 2021 Apr;61(4):493-505. doi: 10.1002/jcph.1757. Epub 2020 Oct 20.

PMID: 33084052

Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.

Liu Q, Xiao HY, Batt DG, Xiao Z, Zhu Y, Yang MG, Li N, Yip S, Li P, Sun D, Wu DR, Ruzanov M, Sack JS, Weigelt CA, Wang J, Li S, Shuster DJ, Xie JH, Song Y, Sherry T, Obermeier MT, Fura A, Stefanski K, Cornelius G, Chacko S, Khandelwal P, Dudhgaonkar S, Rudra A, Nagar J, Murali V, Govindarajan A, Denton R, Zhao Q, Meanwell NA, Borzilleri R, Dhar TGM, et al.

ACS Med Chem Lett. 2021 Apr 30;12(5):827-835. doi: 10.1021/acsmedchemlett.1c00112. eCollection 2021 May 13.

PMID: 34055233

Development and Validation of 3 Preliminary MRI Sacroiliac Joint Composite Structural Damage Scores In a 5-year Longitudinal Axial Spondyloarthritis Study.

Wetterslev M, Østergaard M, Sørensen IJ, Weber U, Loft AG, Kollerup G, Juul L, Thamsborg G, Madsen OR, Møller JM, Pedersen SJ, et al.

J Rheumatol. 2021 Apr 15:jrheum.201075. doi: 10.3899/jrheum.201075. Online ahead of print.

PMID: 33858979

Effects of Denosumab in Japanese Patients With Rheumatoid Arthritis Treated With Conventional Antirheumatic Drugs: 36-month Extension of a Phase III Study.

Tanaka Y, Takeuchi T, Soen S, Yamanaka H, Yoneda T, Tanaka S, Nitta T, Okubo N, Genant HK, van der Heijde D, et al.

J Rheumatol. 2021 Apr 15:jrheum.201376. doi: 10.3899/jrheum.201376. Online ahead of print.

PMID: 33858976

Comparison of Men and Women With Axial Spondyloarthritis in the US-Based Corrona Psoriatic Arthritis/Spondyloarthritis Registry.

Mease PJ, McLean RR, Dube B, Liu M, Rebello S, Glynn M, Yi E, Park Y, Ogdie A, et al.

J Rheumatol. 2021 Apr 15:jrheum.201549. doi: 10.3899/jrheum.201549. Online ahead of print.

PMID: 33858974

Treatment With Tofacitinib in Refractory Psoriatic Arthritis: A National Multicenter Study of the First 87 Patients in Clinical Practice.

Galíndez-Agirregoikoa E, Prieto-Peña D, Martín-Varillas JL, Joven B, Rusinovich O, Melero-González RB, Ortiz-Sanjuan F, Almodóvar R, Alegre-Sancho JJ, Martínez Á, Sellas-Fernández A, Méndez L, García-Vicuña R, Atienza-Mateo B, Gorostiza I, González-Gay MÁ, Blanco R; Tofacitinib PsA Clinical Practice Collaborative Group.

J Rheumatol. 2021 Apr 1:jrheum.201204. doi: 10.3899/jrheum.201204. Online ahead of print.

PMID: 33795330

GRAPPA Trainee Symposium 2020: A Summary of Oral and Poster Presentations.

Richlin CT, Armstrong A, Johnsson H, Mulder MLM.

J Rheumatol. 2021 Apr 1:jrheum.201670. doi: 10.3899/jrheum.201670. Online ahead of print.

PMID: 33795328

Systemic Sclerosis and Associated Interstitial Lung Disease in Ontario, Canada: An Examination of Prevalence and Survival Over 10 Years.

Pope JE, Quansah K, Hassan S, Seung SJ, Flavin J, Kolb M.

J Rheumatol. 2021 Apr 1:jrheum.201049. doi: 10.3899/jrheum.201049. Online ahead of print.

PMID: 33795325

Two-year survival with nivolumab in previously treated advanced non-small-cell lung cancer: A real-world pooled analysis of patients from France, Germany, and Canada.

Debieuvre D, Juergens RA, Asselain B, Audigier-Valette C, Auliac JB, Barlesi F, Benoit N, Bombaron P, Butts CA, Dixmier A, Gröschel A, Gutz S, Labbé C, Moro-Sibilot D, Pérol M, Raspaud C, Schumann C, Juarez-Garcia A, Lakhdari K, Pettersson F, Penrod JR, Reynaud D, Waldenberger D, Allan V, Sebastian M.

Lung Cancer. 2021 Apr 30:S0169-5002(21)00165-3. doi: 10.1016/j.lungcan.2021.04.022. Online ahead of print.

PMID: 33980420

FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective.

Bai JPF, Schmidt BJ, Gadkar KG, Damian V, Earp JC, Friedrich C, van der Graaf PH, Madabushi R, Musante CJ, Naik K, Rogge M, Zhu H.

AAPS J. 2021 Apr 30;23(3):60. doi: 10.1208/s12248-021-00585-x.

PMID: 33931790

"HIGH-RISK" HOST CELL PROTEINS (HCPs): A MULTI-COMPANY COLLABORATIVE VIEW.

Jones M, Palackal N, Wang F, Gaza-Bulseco G, Hurkmans K, Zhao Y, Chitikila C, Clavier S, Liu S, Menesale E, Schonenbach NS, Sharma S, Valax P, Waerner T, Zhang L, Connolly T.

Biotechnol Bioeng. 2021 Apr 30. doi: 10.1002/bit.27808. Online ahead of print.

PMID: 33930190

Fedratinib Improves Myelofibrosis-related Symptoms and Health-related Quality of Life in Patients with Myelofibrosis Previously Treated with Ruxolitinib: Patient-reported Outcomes from the Phase II JAKARTA2 Trial.

Harrison CN, Schaap N, Vannucchi AM, Kiladjian JJ, Jourdan E, Silver RT, Schouten HC, Passamonti F, Zweegman S, Talpaz M, Verstovsek S, Tang D, Abraham P, Lord-Bessen J, Rose S, Guo S, Liao W, Mesa RA.

Hemasphere. 2021 Apr 29;5(5):e562. doi: 10.1097/HS9.0000000000000562. eCollection 2021 May.

PMID: 33969275

Patient-reported Effects of Fedratinib, an Oral, Selective Inhibitor of Janus Kinase 2, on Myelofibrosis-related Symptoms and Health-related Quality of Life in the Randomized, Placebo-controlled, Phase III JAKARTA Trial.

Mesa RA, Schaap N, Vannucchi AM, Kiladjian JJ, Passamonti F, Zweegman S, Talpaz M, Verstovsek S, Rose S, Abraham P, Lord-Bessen J, Tang D, Guo S, Ye X, Harrison CN.

Hemasphere. 2021 Apr 29;5(5):e553. doi: 10.1097/HS9.0000000000000553. eCollection 2021 May.

PMID: 33969273

Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead.

Luo G, Jiang XJ, Chen L, Conway CM, Gulianello M, Kostich W, Keavy D, Signor LJ, Chen P, Davis C, Whiterock VJ, Schartman R, Widmann KA, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2021 Apr 29;43:128077. doi: 10.1016/j.bmcl.2021.128077. Online ahead of print.

PMID: 33932522

Sensitive multiple myeloma disease monitoring by mass spectrometry.

Santockyte R, Jin C, Pratt J, Ammar R, Desai K, Bolisetty M, Das P, Popa-McKiver M, Puig O.

Blood Cancer J. 2021 Apr 29;11(4):78. doi: 10.1038/s41408-021-00473-9.

PMID: 33927186

Population Pharmacokinetics of CC-122.

Cheng Y, Chen J, Pourdehnad M, Zhou S, Li Y.

Clin Pharmacol. 2021 Apr 28;13:61-71. doi: 10.2147/CPAA.S310604. eCollection 2021.

PMID: 33958900

Detection of atrial fibrillation in asymptomatic at-risk individuals.

Langer A, Healey JS, Quinn FR, Honos G, Nault I, Tan M, Camara D, Newman DM, Godin R; AWARE AF Program. Int J Cardiol. 2021 Apr 28:S0167-5273(21)00737-3. doi: 10.1016/j.ijcard.2021.04.048. Online ahead of print.

PMID: 33932428

Novel Advances in Biotransformation and Bioactivation Research - 2020 year in review.

Khojasteh SC, Argikar UA, Driscoll JP, Heck CJS, King L, Jackson KD, Jian W, Kalgutkar AS, Miller GP, Kramlinger V, Rietjens IMCM, Teitelbaum AM, Wang K, Wei C.

Drug Metab Rev. 2021 Apr 28:1-91. doi: 10.1080/03602532.2021.1916028. Online ahead of print.

PMID: 33910427

Development and Validation of a Sensitive, Specific and Reproducible UPLC-MS/MS Method for the Quantification of OJT007, A Novel Anti-Leishmanial Agent: Application to a Pharmacokinetic Study.

Rincon Nigro M, Ma J, Awosemo OT, Xie H, Olaleye OA, Liang D.

Int J Environ Res Public Health. 2021 Apr 27;18(9):4624. doi: 10.3390/ijerph18094624.

PMID: 33925369

Effect of lisocabtagene maraleucel on HRQoL and symptom severity in relapsed/refractory large B-cell lymphoma.

Patrick DL, Powers A, Jun MP, Kim Y, Garcia J, Dehner C, Maloney DG.

Blood Adv. 2021 Apr 27;5(8):2245-2255. doi: 10.1182/bloodadvances.2020003503.

PMID: 33904895

A novel differentiation response with combination IDH inhibitor and intensive induction therapy for AML.

Mason EF, Pozdnyakova O, Roshal M, Fathi AT, Stein EM, Ferrell PB, Shaver AC, Frattini M, Wang H, Hua L, Mu J, Choe S, Xu R, Almon C, Cooper M, Stone RM, Hasserjian RP, Savona MR.

Blood Adv. 2021 Apr 27;5(8):2279-2283. doi: 10.1182/bloodadvances.2020003685.

PMID: 33904894

Dual mTORC1/mTORC2 inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis.

Tasneen R, Mortensen DS, Converse PJ, Urbanowski ME, Upton A, Fotouhi N, Nuermberger E, Hawryluk N.

Antimicrob Agents Chemother. 2021 Apr 26:AAC.00253-21. doi: 10.1128/AAC.00253-21. Online ahead of print.

PMID: 33903099

Using continuous chromatography methodology to achieve high-productivity and high-purity enrichment of charge variants for analytical characterization.

Bigelow E, Song Y, Chen J, Holstein M, Huang Y, Duhamel L, Stone K, Furman R, Li ZJ, Ghose S.

J Chromatogr A. 2021 Apr 26;1643:462008. doi: 10.1016/j.chroma.2021.462008. Epub 2021 Mar 18.

PMID: 33780880

Matching-adjusted indirect treatment comparison of ozanimod versus teriflunomide for relapsing multiple sclerosis.

Cohan S, Tencer T, Arndorfer S, Zhu X, Zivkovic M, Kumar J.

Mult Scler Relat Disord. 2021 Apr 25;52:102972. doi: 10.1016/j.msard.2021.102972. Online ahead of print.

PMID: 33979770

Retrospective Assessment of Clonal Origin of Cell Lines.

Langsdorf E, Yu L, Kanevskaia L, Felkner R, Sturner S, McVey D, Khetan A.

Biotechnol Prog. 2021 Apr 25. doi: 10.1002/btpr.3157. Online ahead of print.

PMID: 33896120

Matching adjusted indirect comparisons of efficacy outcomes for idecabtagene vicleucel (ide-cel, bb2121) versus selinexor + dexamethasone and belantamab mafodotin in relapsed and refractory multiple myeloma.

Rodriguez-Otero P, Ayers D, Cope S, Davies FE, Delforge M, Mojebi A, Jansen JP, Weisel K, Hege K, Dhanasiri S.

Leuk Lymphoma. 2021 Apr 24:1-10. doi: 10.1080/10428194.2021.1913143. Online ahead of print.

PMID: 33896344

Comparison of EQ-5D-3L with QLU-C10D in Metastatic Melanoma Using Cost-Utility Analysis.

Kim H, Cook G, Goodall S, Liew D.

Pharmacoecon Open. 2021 Apr 23. doi: 10.1007/s41669-021-00265-8. Online ahead of print.

PMID: 33891268

CHA₂DS₂-VASc and HAS-BLED risk scores and real-world oral anticoagulant prescribing decisions in atrial fibrillation.

Besford M, Leahy TP, Sammon C, Ulvestad M, Carroll R, Mehmud F, Alikhan R, Ramagopalan S.

Future Cardiol. 2021 Apr 23. doi: 10.2217/fca-2020-0175. Online ahead of print.

PMID: 33890499

Treatment patterns and outcomes in real-world transplant-ineligible patients newly diagnosed with multiple myeloma.

Cejalvo MJ, Bustamante G, González E, Vázquez-Álvarez J, García R, Ramírez-Payer Á, Pérez-Persona E, Abella E, Garzón S, García A, Jarque I, González MS, Sampol A, Motlló C, Martí JM, Alcalá M, Duro R, González Y, Sastre JL, Sarrà J, Lostaunau G, López R, de la Rubia J.

Ann Hematol. 2021 Apr 22. doi: 10.1007/s00277-021-04529-5. Online ahead of print.

PMID: 33885924

Safety and Efficacy of the Combination of Nivolumab Plus Ipilimumab in Patients With Melanoma and Asymptomatic or Symptomatic Brain Metastases (CheckMate 204).

Tawbi HA, Forsyth PA, Hodi FS, Lao CD, Moschos SJ, Hamid O, Atkins MB, Lewis K, Thomas RP, Glaspy JA, Jang S, Algazi AP, Khushalani NI, Postow MA, Pavlick AC, Ernstoff MS, Reardon DA, Puzanov I, Kudchadkar RR, Tarhini AA, Sumbul A, Rizzo JI, Margolin KA.

Neuro Oncol. 2021 Apr 21:noab094. doi: 10.1093/neuonc/noab094. Online ahead of print.

PMID: 33880555

Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration.

Mosquera-Giraldo LI, Donoso M, Stefanski K, Foster K, Gesenberg C, Abraham P, Ren Y, Rose A, Freeden C, Ranasinghe A.

Pharm Res. 2021 Apr 20. doi: 10.1007/s11095-021-03040-w. Online ahead of print.

PMID: 33880721

PCA062, a P-cadherin targeting antibody-drug-conjugate, displays potent anti-tumor activity against P-cadherin-expressing malignancies.

Sheng Q, D'Alessio JA, Menezes DL, Karim C, Tang Y, Tam A, Clark S, Ying C, Connor A, Mansfield KG, Rondeau JM, Ghoddusi M, Geyer FC, Gu J, McLaughlin ME, Newcombe R, Elliott G, Tschantz WR, Lehmann S, Miller K, Huber T, Rendahl KG, Jeffry U, Pryer NK, Lees E, Kwon P, Abraham JA, Damiano JS, Abrams TJ.

Mol Cancer Ther. 2021 Apr 20:molcanther.0708.2020. doi: 10.1158/1535-7163.MCT-20-0708. Online ahead of print.

PMID: 33879555

Physiochemical properties of enveloped viruses and arginine dictate inactivation.

Meingast CL, Joshi PU, Turpeinen DG, Xu X, Holstein M, Feroz H, Ranjan S, Ghose S, Li ZJ, Heldt CL.

Biotechnol J. 2021 Apr 20:e2000342. doi: 10.1002/biot.202000342. Online ahead of print.

PMID: 33877739

Nivolumab and Ipilimumab as Maintenance Therapy in Extensive-Disease Small-Cell Lung Cancer: CheckMate 451.

Owonikoko TK, Park K, Govindan R, Ready N, Reck M, Peters S, Dakhil SR, Navarro A, Rodríguez-Cid J, Schenker M, Lee JS, Gutierrez V, Percent I, Morgensztern D, Barrios CH, Greillier L, Baka S, Patel M, Lin WH, Selvaggi G, Baudelet C, Baden J, Pandya D, Doshi P, Kim HR.

J Clin Oncol. 2021 Apr 20;39(12):1349-1359. doi: 10.1200/JCO.20.02212. Epub 2021 Mar 8.

PMID: 33683919

Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.

Kandasamy R, Hillhouse TM, Livingston KE, Kochan KE, Meurice C, Eans SO, Li MH, White AD, Roques BP, McLaughlin JP, Ingram SL, Burford NT, Alt A, Traynor JR.

Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2000017118. doi: 10.1073/pnas.2000017118.

PMID: 33846240

ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma.

Nowakowski GS, Chiappella A, Gascoyne RD, Scott DW, Zhang Q, Jurczak W, Özcan M, Hong X, Zhu J, Jin J, Belada D, Bergua JM, Piazza F, Mócikova H, Molinari AL, Yoon DH, Cavallo F, Tani M, Yamamoto K, Izutsu K, Kato K, Czuczman M, Hersey S, Kilcoyne A, Russo J, Hudak K, Zhang J, Wade S, Witzig TE, Vitolo U.

J Clin Oncol. 2021 Apr 20;39(12):1317-1328. doi: 10.1200/JCO.20.01366. Epub 2021 Feb 23.

PMID: 33621109

Pediatric Formulation Development - Challenges of Today and Strategies for Tomorrow: Summary Report from M-CERSI Workshop 2019.

Cheng Thiam Tan D, Mei Khong Y, Mount S, Galella E, Mitra B, Charlton S, Kuhli M, Ternik R, Walsh J, Rajapakshe A, Thompson K, Mehrotra S, Santangelo M, Liu J, Dixit T, Schaufelberger D, Jamzad S, Klein S, Hoag SW, Wang J, Pfuma Fletcher E, Khurana M, Alexander J, Radden E, Sood R, Selen A.

Eur J Pharm Biopharm. 2021 Apr 17:S0939-6411(21)00102-8. doi: 10.1016/j.ejpb.2021.04.011. Online ahead of print.

PMID: 33878432

A global approach to long-term follow-up of targeted and immune-based therapy in childhood and adolescence.

Kieran MW, Caron H, Winther JF, Henderson TO, Haupt R, Hjorth L, Hudson MM, Kremer LCM, van der Pal HJ, Pearson ADJ, Pereira L, Reaman G, Skinner R, Vassal G, Weiner SL, Horton Taylor D; ACCELERATE Long-Term Follow-Up Working Group.

Pediatr Blood Cancer. 2021 Apr 16:e29047. doi: 10.1002/pbc.29047. Online ahead of print.

PMID: 33860611

Real-world persistence to direct oral anticoagulants in patients with atrial fibrillation: a systematic review and network meta-analysis.

Deitelzweig S, Di Fusco M, Kang A, Savone M, Mokgokong R, Keshishian A, Gutierrez C, Cappelleri JC.

Curr Med Res Opin. 2021 Apr 16:1-12. doi: 10.1080/03007995.2021.1897555. Online ahead of print.

PMID: 33686900

Quantitative mapping of the cellular small RNA landscape with AQRNA-seq.

Hu JF, Yim D, Ma D, Huber SM, Davis N, Bacusmo JM, Vermeulen S, Zhou J, Begley TJ, DeMott MS, Levine SS, de Crécy-Lagard V, Dedon PC, Cao B.

Nat Biotechnol. 2021 Apr 15. doi: 10.1038/s41587-021-00874-y. Online ahead of print.

PMID: 33859402

An integrated Qual/Quan strategy for ganglioside lipidomics using high-resolution mass spectrometry and Skyline software.

Ranasinghe A, Ciccimaro E Jr, D'Arienzo C, Olah TV, Ponath P, Hnatyshyn S.

Rapid Commun Mass Spectrom. 2021 Apr 15;35(7):e9041. doi: 10.1002/rcm.9041.

PMID: 33415785

Real-world outcomes of immunotherapy-based regimens in first-line advanced non-small cell lung cancer.

Waterhouse D, Lam J, Betts KA, Yin L, Gao S, Yuan Y, Hartman J, Rao S, Lubinga S, Stenehjem D.

Lung Cancer. 2021 Apr 14;156:41-49. doi: 10.1016/j.lungcan.2021.04.007. Online ahead of print.

PMID: 33894493

Treatment patterns in patients with metastatic non-small-cell lung cancer in the era of immunotherapy.

Stenehjem D, Lubinga S, Betts KA, Tang W, Jenkins M, Yuan Y, Hartman J, Rao S, Lam J, Waterhouse D.

Future Oncol. 2021 Apr 14. doi: 10.2217/fon-2021-0230. Online ahead of print.

PMID: 33849296

Statistical analysis of comparative tumor growth repeated measures experiments in the ovarian cancer patient derived xenograft (PDX) setting.

Oberg AL, Heinzen EP, Hou X, Al Hilli MM, Hurley RM, Wahner Hendrickson AE, Goergen KM, Larson MC, Becker MA, Eckel-Passow JE, Maurer MJ, Kaufmann SH, Haluska P, Weroha SJ.

Sci Rep. 2021 Apr 13;11(1):8076. doi: 10.1038/s41598-021-87470-x.

PMID: 33850213

Comparative Efficacy and Safety of Ozanimod and Dimethyl Fumarate for Relapsing-Remitting Multiple Sclerosis Using Matching-Adjusted Indirect Comparison.

Cohan S, Kumar J, Arndorfer S, Zhu X, Zivkovic M, Tencer T.

CNS Drugs. 2021 Apr 13. doi: 10.1007/s40263-021-00805-0. Online ahead of print.

PMID: 33847901

Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen.

Mo Z, Wood S, Namiranian S, Mizukoshi R, Weng S, Jang IS, Fontanillo C, Baughman JM, Silva-Torres A, Slade M, Khater M, Wang K, Rolfe M, Lu G.

Blood Adv. 2021 Apr 13;5(7):2027-2039. doi: 10.1182/bloodadvances.2020003431.

PMID: 33847741

Antibody Disulfide Bond Reduction and Recovery during Biopharmaceutical Process Development - A Review.

Ren T, Tan Z, Ehamparanathan V, Lewandowski A, Ghose S, Li ZJ.

Biotechnol Bioeng. 2021 Apr 12. doi: 10.1002/bit.27790. Online ahead of print.

PMID: 33844277

Confirmed disability progression provides limited predictive information regarding future disease progression in multiple sclerosis.

Healy BC, Glanz BI, Swallow E, Signorovitch J, Hagan K, Silva D, Pelletier C, Chitnis T, Weiner H.

Mult Scler J Exp Transl Clin. 2021 Apr 11;7(2):2055217321999070. doi: 10.1177/2055217321999070. eCollection 2021 Apr-Jun.

PMID: 33953937

Phase II study of propranolol feasibility with neoadjuvant chemotherapy in patients with newly diagnosed breast cancer.

Hopson MB, Lee S, Accordino M, Trivedi M, Maurer M, Crew KD, Hershman DL, Kalinsky K.

Breast Cancer Res Treat. 2021 Apr 10. doi: 10.1007/s10549-021-06210-x. Online ahead of print.

PMID: 33837871

Myeloid Cell-associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing.

Wang L, Sfakianos JP, Beaumont KG, Akturk G, Horowitz A, Sebra RP, Farkas AM, Gnjatic S, Hake A, Izadmehr S, Wiklund P, Oh WK, Szabo PM, Wind-Rotolo M, Unsal-Kacmaz K, Yao X, Schadt E, Sharma P, Bhardwaj N, Zhu J, Galsky MD.

Clin Cancer Res. 2021 Apr 9. doi: 10.1158/1078-0432.CCR-20-4574. Online ahead of print.

PMID: 33837006

Effectiveness of nivolumab affected by prior cetuximab use and neck dissection in Japanese patients with recurrent or metastatic head and neck cancer: results from a retrospective observational study in a real-world setting.

Kariya S, Shimizu Y, Hanai N, Yasumatsu R, Yokota T, Fujii T, Tsukahara K, Yoshida M, Hanyu K, Ueda T, Hirakawa H, Takahashi S, Ono T, Sano D, Yamauchi M, Watanabe A, Omori K, Yamazaki T, Monden N, Kudo N, Arai M, Yonekura S, Asakage T, Fujiwara A, Yamada T, Homma A.

Int J Clin Oncol. 2021 Apr 8. doi: 10.1007/s10147-021-01900-4. Online ahead of print.

PMID: 33830342

Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results.

Advani R, Moskowitz AJ, Bartlett NL, Vose J, Ramchandren R, Feldman T, LaCasce AS, Christian B, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF.

Blood. 2021 Apr 7:blood.2020009178. doi: 10.1182/blood.2020009178. Online ahead of print.

PMID: 33827139

New Peak Detection Performance Metrics from the MAM Consortium Interlaboratory Study.

Mouchahoir T, Schiel JE, Rogers R, Heckert A, Place BJ, Ammerman A, Li X, Robinson T, Schmidt B, Chumsae CM, Li X, Manuilov AV, Yan B, Staples GO, Ren D, Veach AJ, Wang D, Yared W, Sosic Z, Wang Y, Zang L, Leone AM, Liu P, Ludwig R, Tao L, Wu W, Cansizoglu A, Hanneman A, Adams GW, Perdivara I, Walker H, Wilson M, Brandenburg A, DeGraan-Weber N, Gotta S, Shambaugh J, Alvarez M, Yu XC, Cao L, Shao C, Mahan A, Nanda H, Nields K, Nightlinger N, Barysz HM, Jahn M, Niu B, Wang J, Leo G, Sepe N, Liu YH, Patel BA, Richardson D, Wang Y, Tizabi D, Borisov OV, Lu Y, Maynard EL, Gruhler A, Haselmann KF, Krogh TN, Sönksen CP, Letarte S, Shen S, Boggio K, Johnson K, Ni W, Patel H, Ripley D, Rouse JC, Zhang Y, Daniels C, Dawdy A, Friese O, Powers TW, Sperry JB, Woods J, Carlson E, Sen KI, Skilton SJ, Busch M, Lund A, Stapels M, Guo X, Heidelberger S, Kaluarachchi H, McCarthy S, Kim J, Zhen J, Zhou Y, Rogstad S, Wang X, Fang J, Chen W, Yu YQ, Hoogerheide JG, Scott R, Yuan H.

J Am Soc Mass Spectrom. 2021 Apr 7;32(4):913-928. doi: 10.1021/jasms.0c00415. Epub 2021 Mar 12.

PMID: 33710905

Miscalculating equilibrium constants for multivalent protein complexes: Site-binding concentration or protein molecular concentration?

Klakamp SL, Drake AW.

J Pharm Sci. 2021 Apr 6:S0022-3549(21)00195-7. doi: 10.1016/j.xphs.2021.03.026. Online ahead of print.

PMID: 33831440

The Development of Reaction Cascades to Synthesize Dimeric Coccinellid Alkaloids.

Lisnyak VG, Sherwood TC, Snyder SA.

Acc Chem Res. 2021 Apr 6;54(7):1610-1622. doi: 10.1021/acs.accounts.0c00806. Epub 2021 Mar 1.

PMID: 33646762

Molecular risk markers related to local tumor recurrence at histological margin-free endoscopically resected early gastric cancers: A pilot study.

Kang HS, Kwon MJ, Haynes P, Liang Y, Ren Y, Lim H, Soh JS, Kim NY, Lee HK.

Pathol Res Pract. 2021 Apr 5;222:153434. doi: 10.1016/j.prp.2021.153434. Online ahead of print.

PMID: 33857852

Coming of age of Allotrope: Proceedings from the Fall 2020 Allotrope Connect.

Millecam T, Jarrett AJ, Young N, Vanderwall DE, Della Corte D.

Drug Discov Today. 2021 Apr 5:S1359-6446(21)00165-3. doi: 10.1016/j.drudis.2021.03.028. Online ahead of print.

PMID: 33831582

Insights into Glucose-6-phosphate Allosteric Activation of β-Glucosidase A.

A Gomes A, da Silva GF, Lakkaraju SK, Guimarães BG, MacKerell AD Jr, Magalhães MLB.

J Chem Inf Model. 2021 Apr 26;61(4):1931-1941. doi: 10.1021/acs.jcim.0c01450. Epub 2021 Apr 5.

PMID: 33819021

Automated and Faster Affinity Capture Method for Biotransformation Assessment of Site-Specific Antibody Drug Conjugates.

Jashnani A, Kotapati S, Deshpande M, Yamazoe S, Strop P, Rajpal A, Dollinger G.

Anal Chem. 2021 Apr 6;93(13):5371-5376. doi: 10.1021/acs.analchem.0c04685. Epub 2021 Mar 22.

PMID: 33750099

Evaluation of Minimal Important Difference and Responder Definition in the EORTC QLQ-PAN26 Module for Assessing Health-Related Quality of Life in Patients with Surgically Resected Pancreatic Adenocarcinoma.

Reni M, Braverman J, Hendifar A, Li CP, Macarulla T, Oh DY, Riess H, Tempero M, Lu B, Marcus J, Joshi N, Botteman M, Dueck AC.

Ann Surg Oncol. 2021 Apr 3. doi: 10.1245/s10434-021-09816-z. Online ahead of print.

PMID: 33813673

Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO).

Hu CH, Neissel Valente MW, Halpern OS, Jusuf S, Khan JA, Locke GA, Duke GJ, Liu X, Duclos FJ, Wexler RR, Kick EK, Smallheer JM.

Bioorg Med Chem Lett. 2021 Apr 1;42:128010. doi: 10.1016/j.bmcl.2021.128010. Online ahead of print.

PMID: 33811992

A catalog of GWAS fine-mapping efforts in autoimmune disease.

Caliskan M, Brown CD, Maranville JC.

Am J Hum Genet. 2021 Apr 1;108(4):549-563. doi: 10.1016/j.ajhg.2021.03.009.

PMID: 33798443

Development of an international template to support patient submissions in Health Technology Assessments.

Cook N, Livingstone H, Dickson J, Taylor L, Morgan K, Coombes M, Wortley S, Oehrlein E, Vicente-Edo MJ, Waibel F, Liden B.

Int J Technol Assess Health Care. 2021 Apr 1;37(1):e50. doi: 10.1017/S0266462321000167.

PMID: 33789779

Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer.

Kelly RJ, Ajani JA, Kuzdzal J, Zander T, Van Cutsem E, Piessen G, Mendez G, Feliciano J, Motoyama S, Lièvre A, Uronis H, Elimova E, Grootscholten C, Geboes K, Zafar S, Snow S, Ko AH, Feeney K, Schenker M, Kocon P, Zhang J, Zhu L, Lei M, Singh P, Kondo K, Cleary JM, Moehler M; CheckMate 577 Investigators.

N Engl J Med. 2021 Apr 1;384(13):1191-1203. doi: 10.1056/NEJMoa2032125.

PMID: 33789008

Achieving a low human dose for targeted covalent drugs: Pharmacokinetic and pharmacodynamic considerations on target characteristics and drug attributes.

Yang Z.

Biopharm Drug Dispos. 2021 Apr;42(4):150-159. doi: 10.1002/bdd.2263. Epub 2021 Apr 2.

PMID: 33547681

Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma.

Da Vià MC, Dietrich O, Truger M, Arampatzi P, Duell J, Heidemeier A, Zhou X, Danhof S, Kraus S, Chatterjee M, Meggendorfer M, Twardziok S, Goebeler ME, Topp MS, Hudecek M, Prommersberger S, Hege K, Kaiser S, Fuhr V, Weinhold N, Rosenwald A, Erhard F, Haferlach C, Einsele H, Kortüm KM, Saliba AE, Rasche L.

Nat Med. 2021 Apr;27(4):616-619. doi: 10.1038/s41591-021-01245-5. Epub 2021 Feb 22.

PMID: 33619368

Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1).

Fisher MJ, Jones DTW, Li Y, Guo X, Sonawane PS, Waanders AJ, Phillips JJ, Weiss WA, Resnick AC, Gosline S, Banerjee J, Guinney J, Gnekow A, Kandels D, Foreman NK, Korshunov A, Ryzhova M, Massimi L, Gururangan S, Kieran MW, Wang Z, Fouladi M, Sato M, Øra I, Holm S, Markham SJ, Beck P, Jäger N, Wittmann A, Sommerkamp AC, Sahm F, Pfister SM, Gutmann DH.

Acta Neuropathol. 2021 Apr;141(4):605-617. doi: 10.1007/s00401-021-02276-5. Epub 2021 Feb 14.

PMID: 33585982

A matching-adjusted indirect comparison of combination nivolumab plus ipilimumab with BRAF plus MEK inhibitors for the treatment of BRAF-mutant advanced melanoma^☆.

Tarhini AA, Toor K, Chan K, McDermott DF, Mohr P, Larkin J, Hodi FS, Lee CH, Rizzo JI, Johnson H, Moshyk A, Rao S, Kotapati S, Atkins MB.

ESMO Open. 2021 Apr;6(2):100050. doi: 10.1016/j.esmoop.2021.100050. Epub 2021 Feb 6.

PMID: 33556898

Identification and stratification of systemic lupus erythematosus patients into two transcriptionally distinct clusters based on IFN-I signature.

Shobha V, Mohan A, Malini AV, Chopra P, Karunanithi P, Subramani Thulasingam S, Selvam S, Deyati A, Srivastava R, Basavanthappa S, Lemos N, Sunitha SM, Mazumder Tagore D, Anand A, Pant S, Jayaswal V, Ramarao M, Dudhgaonkar S.

Lupus. 2021 Apr;30(5):762-774. doi: 10.1177/0961203321990107. Epub 2021 Jan 26.

PMID: 33497307

First-Line Nivolumab Plus Ipilimumab Versus Chemotherapy in Advanced NSCLC With 1% or Greater Tumor PD-L1 Expression: Patient-Reported Outcomes From CheckMate 227 Part 1.

Reck M, Ciuleanu TE, Lee JS, Schenker M, Audigier-Valette C, Zurawski B, Linardou H, Otterson GA, Salman P, Nishio M, de la Mora Jimenez E, Lesniewski-Kmak K, Albert I, Ahmed S, Syrigos K, Penrod JR, Yuan Y, Blum SI, Nathan FE, Sun X, Moreno-Koehler A, Taylor F, O'Byrne KJ.

J Thorac Oncol. 2021 Apr;16(4):665-676. doi: 10.1016/j.jtho.2020.12.019. Epub 2021 Jan 21.

PMID: 33485960

Network meta-analysis of nivolumab plus ipilimumab in the second-line setting for advanced hepatocellular carcinoma.

Parikh ND, Marshall A, Betts KA, Song J, Zhao J, Yuan M, Wu A, Huff KD, Kim R.

J Comp Eff Res. 2021 Apr;10(5):343-352. doi: 10.2217/cer-2020-0236. Epub 2021 Jan 14.

PMID: 33442996

Spatial presence depends on 'coupling' between body sway and visual motion presented on head-mounted displays (HMDs).

Chowdhury NS, Luu W, Palmisano S, Ujike H, Kim J.

Appl Ergon. 2021 Apr;92:103355. doi: 10.1016/j.apergo.2021.103355. Epub 2021 Jan 11.

PMID: 33444884

Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation.

Rivers-Auty J, Tapia VS, White CS, Daniels MJD, Drinkall S, Kennedy PT, Spence HG, Yu S, Green JP, Hoyle C, Cook J, Bradley A, Mather AE, Peters R, Tzeng TC, Gordon MJ, Beattie JH, Brough D, Lawrence CB.

J Neurosci. 2021 Mar 31;41(13):3025-3038. doi: 10.1523/JNEUROSCI.1980-20.2020. Epub 2021 Feb 17.

PMID: 33597269

Hydrophilic and Functionalized Nanographene Oxide Incorporated Faster Dissolving Megestrol Acetate.

Islam MS, Renner F, Foster K, Oderinde MS, Stefanski K, Mitra S.

Molecules. 2021 Mar 31;26(7):1972. doi: 10.3390/molecules26071972.

PMID: 33807401

DeepGRAI (Deep Gray Rating via Artificial Intelligence): Fast, feasible, and clinically relevant thalamic atrophy measurement on clinical quality T2-FLAIR MRI in multiple sclerosis.

Dwyer M, Lyman C, Ferrari H, Bergsland N, Fuchs TA, Jakimovski D, Schweser F, Weinstock-Guttmann B, Benedict RHB, Riolo J, Silva D, Zivadinov R.

Neuroimage Clin. 2021 Mar 29;30:102652. doi: 10.1016/j.nicl.2021.102652. Online ahead of print.

PMID: 33872992

Cycling of tumor necrosis factor inhibitors versus switching to different mechanism of action therapy in rheumatoid arthritis patients with inadequate response to tumor necrosis factor inhibitors: a Bayesian network meta-analysis.

Migliore A, Pompilio G, Integlia D, Zhuo J, Alemao E.

Ther Adv Musculoskelet Dis. 2021 Mar 29;13:1759720X211002682. doi: 10.1177/1759720X211002682. eCollection 2021.

PMID: 33854570

Combination of azacitidine and enasidenib enhances leukemic cell differentiation and cooperatively hypomethylates DNA.

MacBeth KJ, Chopra VS, Tang L, Zheng B, Avanzino B, See WL, Schwickart M, Figueroa ME, Quek L, DiMartino JF.

Exp Hematol. 2021 Mar 29:S0301-472X(21)00128-4. doi: 10.1016/j.exphem.2021.03.003. Online ahead of print.

PMID: 33794295

Analyses of PD-L1 and Inflammatory Gene Expression Association with Efficacy of Nivolumab ± Ipilimumab in Gastric Cancer/Gastroesophageal Junction Cancer.

Lei M, Siemers NO, Pandya D, Chang H, Sanchez T, Harbison C, Szabo PM, Janjigian Y, Ott PA, Sharma P, Bendell J, Evans TRJ, de Braud F, Chau I, Boyd Z.

Clin Cancer Res. 2021 Mar 29. doi: 10.1158/1078-0432.CCR-20-2790. Online ahead of print.

PMID: 33782030

Treatment patterns and outcomes of patients with advanced malignant pleural mesothelioma in a community practice setting.

Waterhouse DM, Nwokeji ED, Boyd M, Penrod JR, Espirito JL, Robert NJ, Daumont MJ.

Future Oncol. 2021 Mar 26. doi: 10.2217/fon-2021-0047. Online ahead of print.

PMID: 33769073

Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate.

Johnson JA, Kim SH, Jiang J, Phillips M, Schumacher WA, Bostwick JS, Gargalovic PS, Onorato JM, Luk CE, Generaux C, He Y, Chen XQ, Xu C, Galella MA, Wang T, Gordon DA, Wexler RR, Finlay HJ.

J Med Chem. 2021 Mar 25;64(6):3086-3099. doi: 10.1021/acs.jmedchem.0c01878. Epub 2021 Mar 9.

PMID: 33689340

Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome.

Chen YH, Zastrow DB, Metcalfe RD, Gartner L, Krause F, Morton CJ, Marwaha S, Fresard L, Huang Y, Zhao C, McCormack C, Bick D, Worthey EA, Eng CM, Gold J, Undiagnosed Diseases Network, Montgomery SB, Fisher PG, Ashley EA, Wheeler MT, Parker MW, Shanmugasundaram V, Putoczki TL, Schmidt-Arras D, Laurence A, Bernstein JA, Griffin MDW, Uhlig HH.

J Allergy Clin Immunol. 2021 Mar 23:S0091-6749(21)00471-1. doi: 10.1016/j.jaci.2021.02.044. Online ahead of print.

PMID: 33771552

Fc-optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models.

Campbell JR, McDonald BR, Mesko PB, Siemers NO, Singh PB, Selby M, Sproul TW, Korman AJ, Vlach LM, Houser J, Sambanthamoorthy S, Lu K, Hatcher SV, Lohre J, Jain R, Lan RY.

Cancer Res. 2021 Mar 23:canres.3585.2020. doi: 10.1158/0008-5472.CAN-20-3585. Online ahead of print.

PMID: 33757978

Cytokine release syndrome and neurological event costs in lisocabtagene maraleucel-treated patients in the TRANSCEND NHL 001 trial.

Abramson JS, Siddiqi T, Garcia J, Dehner C, Kim Y, Nguyen A, Snyder S, McGarvey N, Gitlin M, Pelletier C, Jun MP.

Blood Adv. 2021 Mar 23;5(6):1695-1705. doi: 10.1182/bloodadvances.2020003531.

PMID: 33720336

Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients With Atrial Fibrillation After Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial.

Hijazi Z, Alexander JH, Li Z, Wojdyla DM, Mehran R, Granger CB, Parkhomenko A, Bahit MC, Windecker S, Aronson R, Berwanger O, Halvorsen S, de Waha-Thiele S, Sinnaeve P, Darius H, Storey RF, Lopes RD.

Circulation. 2021 Mar 23;143(12):1215-1223. doi: 10.1161/CIRCULATIONAHA.120.051020. Epub 2021 Jan 19.

PMID: 33461308

Investigation into the Role of ERK in Tyrosine Kinase Inhibitor-Induced Neuropathy.

Belair DG, Sudak K, Connelly K, Collins ND, Kopytek SJ, Kolaja KL.

Toxicol Sci. 2021 Mar 22:kfab033. doi: 10.1093/toxsci/kfab033. Online ahead of print.

PMID: 33749749

Burden of major gastrointestinal bleeding among oral anticoagulant-treated non-valvular atrial fibrillation patients.

Deitelzweig S, Keshishian A, Kang A, Dhamane AD, Luo X, Balachander N, Rosenblatt L, Mardekian J, Jiang J, Yuce H, Lip GYH.

Therap Adv Gastroenterol. 2021 Mar 21;14:1756284821997352. doi: 10.1177/1756284821997352. eCollection 2021.

PMID: 33815568

Analysis of biopharmaceutical formulations by Time Domain Nuclear Magnetic Resonance (TD-NMR) spectroscopy: A potential method for detection of counterfeit biologic pharmaceuticals.

Akhunzada Z, Wu Y, Haby T, Jayawickrama D, McGeorge G, La Colla M, Bernstein J, Semones M, Abraham A.

J Pharm Sci. 2021 Mar 18:S0022-3549(21)00180-5. doi: 10.1016/j.xphs.2021.03.011. Online ahead of print.

PMID: 33745914

Response: Letter To The Editor.

Harris DE, Wang T, Lister S, Halcox J.

Eur Heart J Cardiovasc Pharmacother. 2021 Mar 18:pvab021. doi: 10.1093/ehjcvp/pvab021. Online ahead of print.

PMID: 33734310

Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2-Oxaspiro[3.3]heptanes.

Murray PRD, Bussink WMM, Davies GHM, van der Mei FW, Antropow AH, Edwards JT, D'Agostino LA, Ellis JM, Hamann LG, Romanov-Michailidis F, Knowles RR.

J Am Chem Soc. 2021 Mar 17;143(10):4055-4063. doi: 10.1021/jacs.1c01173. Epub 2021 Mar 5.

PMID: 33666086

Overview of Causality Assessment for Drug-Induced Liver Injury (DILI) in Clinical Trials.

Hey-Hadavi J, Seekins D, Palmer M, Coffey D, Caminis J, Abdullaev S, Patwardhan M, Tyler H, Raheja R, Stanley AM, Pineda-Salgado L, Bourdet DL, Andrade RJ, Hayashi PH, Dimick-Santos L, Rockey DC, Estilo A.

Drug Saf. 2021 Mar 16. doi: 10.1007/s40264-021-01051-5. Online ahead of print.

PMID: 33725335

Effect of Terminal Alkylation of Aryl and Heteroaryl Hydrazines in the Fischer Indole Synthesis.

Schmidt MA.

J Org Chem. 2021 Mar 16. doi: 10.1021/acs.joc.1c00203. Online ahead of print.

PMID: 33724835

Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.

Swidorski JJ, Jenkins S, Hanumegowda U, Parker DD, Beno BR, Protack T, Ng A, Gupta A, Shanmugam Y, Dicker IB, Krystal M, Meanwell NA, Regueiro-Ren A.

Bioorg Med Chem Lett. 2021 Mar 15;36:127823. doi: 10.1016/j.bmcl.2021.127823. Epub 2021 Jan 26.

PMID: 33508465

Association between red blood cell transfusion dependence and burden in patients with myelodysplastic syndromes: A systematic literature review and meta-analysis.

Braga Lemos M, Rodrigues SR, Schroeder T, Kulasekararaj AG, E Matos J, Tang D.

Eur J Haematol. 2021 Mar 14. doi: 10.1111/ejh.13619. Online ahead of print.

PMID: 33715214

U.S. FDA Approved Drugs from 2015-June 2020: A Perspective.

Bhutani P, Joshi G, Raja N, Bachhav N, Rajanna PK, Bhutani H, Paul AT, Kumar R.

J Med Chem. 2021 Mar 11;64(5):2339-2381. doi: 10.1021/acs.jmedchem.0c01786. Epub 2021 Feb 22.

PMID: 33617716

Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.

Yang MG, Beaudoin-Bertrand M, Xiao Z, Marcoux D, Weigelt CA, Yip S, Wu DR, Ruzanov M, Sack JS, Wang J, Yarde M, Li S, Shuster DJ, Xie JH, Sherry T, Obermeier MT, Fura A, Stefanski K, Cornelius G, Khandelwal P, Karmakar A, Basha M, Babu V, Gupta AK, Mathur A, Salter-Cid L, Denton R, Zhao Q, Dhar TGM.

J Med Chem. 2021 Mar 11;64(5):2714-2724. doi: 10.1021/acs.jmedchem.0c01992. Epub 2021 Feb 16.

PMID: 33591748

Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity.

Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saigi M, Campisi M, Hong D, Thai TC, Piel B, Han S, Reinhold BB, Duke-Cohan JS, Poitras MJ, Taus LJ, Lizotte PH, Portell A, Quadros V, Santucci AD, Murayama T, Canadas I, Kitajima S, Akitsu A, Fridrikh M, Watanabe H, Reardon B, Gokhale PC, Paweletz CP, Awad MM, Van Allen EM, Lako A, Wang XT, Chen B, Hong F, Sholl LM, Tolstorukov MY, Pfaff K, Janne PA, Gjini E, Edwards R, Rodig S, Reinherz EL, Oser MG, Barbie DA.

Cancer Discov. 2021 Mar 11:candisc.0913.2020. doi: 10.1158/2159-8290.CD-20-0913. Online ahead of print.

PMID: 33707236

Results of a phase 2, multicenter, single-arm, open-label study of lenalidomide in pediatric patients with relapsed or refractory acute myeloid leukemia.

O'Brien MM, Alonzo TA, Cooper TM, Levine JE, Brown PA, Slone T, August KJ, Benettaib B, Biserna N, Poon J, Patturajan M, Chen N, Simcock M, Zimmerman L, Kolb EA.

Pediatr Blood Cancer. 2021 Mar 10:e28946. doi: 10.1002/pbc.28946. Online ahead of print.

PMID: 33694257

A Multi-variate Mathematical Model for Simulating the Granule Size Distribution in Roller Compaction-Milling Process.

Amini H, Akseli I.

AAPS PharmSciTech. 2021 Mar 10;22(3):97. doi: 10.1208/s12249-021-01955-6.

PMID: 33694033

Influence of prognosis factors on the prescription of targeted treatments in rheumatoid arthritis: A Delphi survey.

Narváez J, Otón T, Calvo-Alén J, Escudero-Contreras A, Muñoz-Fernández S, Rodríguez-Heredia JM, Romero-Yuste S, Vela-Casasempere P, Luján S, Baquero JL, Carmona L.

Joint Bone Spine. 2021 Mar 6;88(4):105172. doi: 10.1016/j.jbspin.2021.105172. Online ahead of print.

PMID: 33689842

Process analytical technology for on-line monitoring of quality attributes during single-use ultrafiltration/diafiltration.

West JM, Feroz H, Xu X, Puri N, Holstein M, Ghose S, Ding J, Li ZJ.

Biotechnol Bioeng. 2021 Mar 5. doi: 10.1002/bit.27741. Online ahead of print.

PMID: 33666234

Origin Sample Prediction and Spatial Modeling of Antimicrobial Resistance in Metagenomic Sequencing Data.

Zhelyazkova M, Yordanova R, Mihaylov I, Kirov S, Tsonev S, Danko D, Mason C, Vassilev D.

Front Genet. 2021 Mar 4;12:642991. doi: 10.3389/fgene.2021.642991. eCollection 2021.

PMID: 33763122

Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, Oyervides Juárez VM, Hsieh JJ, Basso U, Shah AY, Suárez C, Hamzaj A, Goh JC, Barrios C, Richardet M, Porta C, Kowalyszyn R, Feregrino JP, Żołnierek J, Pook D, Kessler ER, Tomita Y, Mizuno R, Bedke J, Zhang J, Maurer MA, Simsek B, Ejzykowicz F, Schwab GM, Apolo AB, Motzer RJ; CheckMate 9ER Investigators.

N Engl J Med. 2021 Mar 4;384(9):829-841. doi: 10.1056/NEJMoa2026982.

PMID: 33657295

Solvent-specific, DAST-mediated intramolecular Friedel-Crafts reaction: access to dibenzoxepine-fused spirooxindoles.

Samikannu R, Sethuraman S, Akula N, Radhakrishnan V, Kamisetti S, Banu S, Vetrichelvan M, Gupta A, Li J, Rampulla R, Mathur A.

Org Biomol Chem. 2021 Mar 4;19(8):1760-1768. doi: 10.1039/d0ob02461a.

PMID: 33538747

Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy.

Zhang L, Cherney EC, Zhu X, Lin TA, Gullo-Brown J, Maley D, Johnston-Allegretto K, Kopcho L, Fereshteh M, Huang C, Li X, Traeger SC, Dhar G, Anandam A, Mahankali S, Padmanabhan S, Rajanna P, Murali V, Mariappan T, Borzilleri R, Vite G, Hunt JT, Balog A.

ACS Med Chem Lett. 2021 Mar 2;12(3):494-501. doi: 10.1021/acsmedchemlett.1c00014. eCollection 2021 Mar 11.

PMID: 33738077

Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.

Wang F, Chau B, West SM, Kimberlin CR, Cao F, Schwarz F, Aguilar B, Han M, Morishige W, Bee C, Dollinger G, Rajpal A, Strop P.

Nat Commun. 2021 Mar 2;12(1):1378. doi: 10.1038/s41467-021-21563-z.

PMID: 33654081

The safety and efficacy of dasatinib plus nivolumab in patients with previously treated chronic myeloid leukemia: results from a phase 1b dose-escalation study.

Martínez-López J, Mustjoki S, Porkka K, Klisovic RB, Wolf D, Busque L, Hernández-Boluda JC, Swanink R, Martin Regueira P, Lipton JH.

Leuk Lymphoma. 2021 Mar 2:1-7. doi: 10.1080/10428194.2021.1889536. Online ahead of print.

PMID: 33653205

Suppression of Electrostatic Mediated Antibody Liquid-Liquid Phase Separation by Charged and Noncharged Preferentially Excluded Excipients.

Banks DD, Cordia JF.

Mol Pharm. 2021 Mar 1;18(3):1285-1292. doi: 10.1021/acs.molpharmaceut.0c01138. Epub 2021 Feb 8.

PMID: 33555888

Loss-in-weight feeding, powder flow and electrostatic evaluation for direct compression hydroxypropyl methylcellulose (HPMC) to support continuous manufacturing.

Allenspach C, Timmins P, Lumay G, Holman J, Minko T.

Int J Pharm. 2021 Mar 1;596:120259. doi: 10.1016/j.ijpharm.2021.120259. Epub 2021 Jan 21.

PMID: 33486020

AAPS Perspective on the EURL Recommendation on the use of Non-Animal-Derived Antibodies.

Gorovits B, Hays A, Jani D, Jones C, King C, Lundequist A, Mora J, Partridge M, Pathania D, Ramaswamy SS, Rutwij D, Shen H, Starling G.

AAPS J. 2021 Mar 1;23(2):34. doi: 10.1208/s12248-021-00567-z.

PMID: 33649990

Five-Year Outcomes From the Randomized, Phase III Trials CheckMate 017 and 057: Nivolumab Versus Docetaxel in Previously Treated Non-Small-Cell Lung Cancer.

Borghaei H, Gettinger S, Vokes EE, Chow LQM, Burgio MA, de Castro Carpeno J, Pluzanski A, Arrieta O, Frontera OA, Chiari R, Butts C, Wójcik-Tomaszewska J, Coudert B, Garassino MC, Ready N, Felip E, García MA, Waterhouse D, Domine M, Barlesi F, Antonia S, Wohlleber M, Gerber DE, Czyzewicz G, Spigel DR, Crino L, Eberhardt WEE, Li A, Marimuthu S, Brahmer J.

J Clin Oncol. 2021 Mar 1;39(7):723-733. doi: 10.1200/JCO.20.01605. Epub 2021 Jan 15.

PMID: 33449799

Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists.

Ruan Z, Park PK, Wei D, Purandare A, Wan H, O'Malley D, Stachura S, Perez H, Cavallaro CL, Weigelt CA, Sack JS, Ruzanov M, Khan J, Gururajan M, Wong JJ, Huang Y, Yarde M, Li Z, Chen C, Sun H, Borowski V, Xie JH, Anthony M, Agler M, Fink BE, Harikrishnan LS.

Bioorg Med Chem Lett. 2021 Mar 1;35:127778. doi: 10.1016/j.bmcl.2021.127778. Epub 2021 Jan 8.

PMID: 33422603

Best practices for selection of excipients for paediatrics - Workshop reflection.

Salunke S, Clapham D, Agrawal A, Hughes K, Nunn T.

Eur J Pharm Biopharm. 2021 Mar;160:77-81. doi: 10.1016/j.ejpb.2020.12.021. Epub 2021 Jan 2.

PMID: 33400989

Risk Prediction Using Bayesian Networks: An Immunotherapy Case Study in Patients With Metastatic Renal Cell Carcinoma.

Gupta A, Arora P, Brenner D, Vanderpuye-Orgle J, Boyne DJ, Edmondson-Jones M, Parkhomenko E, Stevens W, Dudani S, Heng DYC, Wagner S, Borrill J, Wu E.

JCO Clin Cancer Inform. 2021 Mar;5:326-337. doi: 10.1200/CCI.20.00107.

PMID: 33764818

Understanding the pathway and kinetics of aspartic acid isomerization in peptide mapping methods for monoclonal antibodies.

Kuang J, Tao Y, Song Y, Chemmalil L, Mussa N, Ding J, Li ZJ.

Anal Bioanal Chem. 2021 Mar;413(8):2113-2123. doi: 10.1007/s00216-021-03176-z. Epub 2021 Feb 5.

PMID: 33543314

Validating Intelligent Automation Systems in Pharmacovigilance: Insights from Good Manufacturing Practices.

Huysentruyt K, Kjoersvik O, Dobracki P, Savage E, Mishalov E, Cherry M, Leonard E, Taylor R, Patel B, Abatemarco D.

Drug Saf. 2021 Mar;44(3):261-272. doi: 10.1007/s40264-020-01030-2. Epub 2021 Feb 1.

PMID: 33523400

2020 White Paper on Recent Issues in Bioanalysis: BAV Guidance, CLSI H62, Biotherapeutics Stability, Parallelism Testing, CyTOF and Regulatory Feedback (Part 2A - Recommendations on Biotherapeutics Stability, PK LBA Regulated Bioanalysis, Biomarkers Assays, Cytometry Validation & Innovation Part 2B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).

Spitz S, Zhang Y, Fischer S, McGuire K, Sommer U, Amaravadi L, Bandukwala A, Eck S, Garofolo F, Islam R, Jordan G, King L, Saito Y, Sumner G, Terry L, Vitaliti A, Wang YM, Grimaldi C, Joyce A, Palmer R, Andisik M, Araya M, Azadeh M, Baltrukonis D, Elliott R, Haidar S, Kumar S, Mayer A, Neff F, Palackal N, Peng K, Abhari MR, Satterwhite C, Savoie N, Soo C, Vinter S, Welink J, Yan W, Maher K, Lanham D, Bertholet S, Dakappagari N, Gonneau C, Green C, Junker F, Kar S, Patti-Diaz L, Sarikonda S, McCausland M, Teixeira PC, Decman V, Estevam J, Hedrick M, Robert AH, Hopkins G, Nuti S, Tangri S, Wnek R, Dandamudi S, Dasgupta A, Edmison A, Faustino P, McGuinness M, Lima Santos GM, Mirza T, Shakleya D, Stojdl S, Tampal N, Zhang J, Cherry E, Cludts I, Exley A, Ishii-Watabe A, Kirshner S, Pedras-Vasconcelos J, Shen M, Siggers R, Solstad T, Verthelyi D, Yan H, Zhang L.

Bioanalysis. 2021 Mar;13(5):295-361. doi: 10.4155/bio-2021-0005. Epub 2021 Jan 29.

PMID: 33511867

The Dollar or Disease Burden: Caps on Healthcare Spending May Save Money, but at What "Cost" to Patients?

Ciarametaro M, Houghton K, Wamble D, Dubois R.

Value Health. 2021 Mar;24(3):388-396. doi: 10.1016/j.jval.2020.10.024. Epub 2021 Jan 28.

PMID: 33641773

Prevalence of autoimmune diseases and other associated conditions in children and young adults with juvenile idiopathic arthritis.

Lovell DJ, Huang B, Chen C, Angeles-Han ST, Simon TA, Brunner HI.

RMD Open. 2021 Mar;7(1):e001435. doi: 10.1136/rmdopen-2020-001435.

PMID: 33731444

What Did Time Tell Us? A Comparison and Retrospective Validation of Different Survival Extrapolation Methods for Immuno-Oncologic Therapy in Advanced or Metastatic Renal Cell Carcinoma.

Klijn SL, Fenwick E, Kroep S, Johannesen K, Malcolm B, Kurt M, Kiff C, Borrill J.

Pharmacoeconomics. 2021 Mar;39(3):345-356. doi: 10.1007/s40273-020-00989-1. Epub 2021 Jan 11.

PMID: 33428174

Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus.

Rivellese F, Manou-Stathopoulou S, Mauro D, Goldmann K, Pyne D, Rajakariar R, Gordon P, Schafer P, Bombardieri M, Pitzalis C, Lewis MJ.

Lupus Sci Med. 2021 Mar;8(1):e000445. doi: 10.1136/lupus-2020-000445.

PMID: 33727237

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.

Gargalovic P, Wong P, Onorato J, Finlay H, Wang T, Yan M, Crain E, St-Onge S, Héroux M, Bouvier M, Xu C, Chen XQ, Generaux C, Lawrence M, Wexler R, Gordon D.

Circ Heart Fail. 2021 Mar;14(3):e007351. doi: 10.1161/CIRCHEARTFAILURE.120.007351. Epub 2021 Mar 5.

PMID: 33663236

High-molecular weight impurity screening by size-exclusion chromatography on a reversed-phase column.

Lin Z, Ye YK, Ling M, Shackman JG, Ileka KM, Raglione TV.

J Pharm Biomed Anal. 2021 Mar 20;196:113908. doi: 10.1016/j.jpba.2021.113908. Epub 2021 Jan 18.

PMID: 33497976

Development of an Actionable Framework to Address Cancer Care Disparities in Medically Underserved Populations in the United States: Expert Roundtable Recommendations.

Winkfield KM, Regnante JM, Miller-Sonet E, González ET, Freund KM, Doykos PM.

JCO Oncol Pract. 2021 Mar;17(3):e278-e293. doi: 10.1200/OP.20.00630. Epub 2021 Jan 18.

PMID: 33464925

A bridging immunogenicity assay for anti-cabiralizumab antibodies: overcoming the low assay cut point and drug tolerance challenges.

Yuan L, Gleason CR, Stocker D, Li L, Shen JX, Ji QC.

Bioanalysis. 2021 Mar;13(5):395-407. doi: 10.4155/bio-2020-0300. Epub 2021 Mar 4.

PMID: 33661021

Evaluating the Effectiveness of Apixaban Additional Risk Minimisation Measures Using Surveys in Europe.

Mayall S, Kahlon R, Al-Dakkak I, Shen SW.

Pharmaceut Med. 2021 Mar;35(2):123-135. doi: 10.1007/s40290-021-00380-1. Epub 2021 Mar 4.

PMID: 33660230

Molecular correlates of response to nivolumab at baseline and on treatment in patients with RCC.

Ross-Macdonald P, Walsh AM, Chasalow SD, Ammar R, Papillon-Cavanagh S, Szabo PM, Choueiri TK, Sznol M, Wind-Rotolo M.

J Immunother Cancer. 2021 Mar;9(3):e001506. doi: 10.1136/jitc-2020-001506.

PMID: 33658305

Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2.

Gyimesi M, Rauscher AÁ, Suthar SK, Hamow KÁ, Oravecz K, Lőrincz I, Borhegyi Z, Déri MT, Kiss ÁF, Monostory K, Szabó PT, Nag S, Tomasic I, Krans J, Tierney PJ, Kovács M, Kornya L, Málnási-Csizmadia A.

J Pharmacol Exp Ther. 2021 Mar;376(3):358-373. doi: 10.1124/jpet.120.000167. Epub 2021 Jan 19.

PMID: 33468641

Bromodomain and extra-terminal inhibitors-A consensus prioritisation after the Paediatric Strategy Forum for medicinal product development of epigenetic modifiers in children-ACCELERATE.

Pearson AD, DuBois SG, Buenger V, Kieran M, Stegmaier K, Bandopadhayay P, Bennett K, Bourdeaut F, Brown PA, Chesler L, Clymer J, Fox E, French CA, Germovsek E, Giles FJ, Bender JG, Hattersley MM, Ludwinski D, Luptakova K, Maris J, McDonough J, Nikolova Z, Smith M, Tsiatis AC, Vibhakar R, Weiner S, Yi JS, Zheng F, Vassal G.

Eur J Cancer. 2021 Mar;146:115-124. doi: 10.1016/j.ejca.2021.01.018. Epub 2021 Feb 16.

PMID: 33601323

The FALCON program: Two phase 2b randomized, double-blind, placebo-controlled studies to assess the efficacy and safety of pegbelfermin in the treatment of patients with nonalcoholic steatohepatitis and bridging fibrosis or compensated cirrhosis.

Abdelmalek MF, Charles ED, Sanyal AJ, Harrison SA, Neuschwander-Tetri BA, Goodman Z, Ehman RA, Karsdal M, Nakajima A, Du S, Tirucherai GS, Klinger GH, Mora J, Yamaguchi M, Shevell DE, Loomba R.

Contemp Clin Trials. 2021 Feb 28;104:106335. doi: 10.1016/j.cct.2021.106335. Online ahead of print.

PMID: 33657443

Special Convening and Listening Session on Health Equity and Community Outreach and Engagement at National Cancer Institute-Designated Comprehensive Cancer Centers.

Doykos PM, Chen MS Jr, Watson K, Henderson V, Baskin ML, Downer S, Smith LA, Bhavaraju N, Dina S, Lathan CS.

Health Equity. 2021 Feb 26;5(1):84-90. doi: 10.1089/heq.2020.0155. eCollection 2021.

PMID: 33681694

Recommendations from a Dialogue on Evolving National Cancer Institute-Designated Comprehensive Cancer Center Community Outreach and Engagement Requirements: A Path Forward.

Doykos PM, Chen MS Jr, Watson K, Henderson V, Baskin ML, Downer S, Smith LA, Bhavaraju N, Dina S, Lathan CS.

Health Equity. 2021 Feb 26;5(1):76-83. doi: 10.1089/heq.2020.0156. eCollection 2021.

PMID: 33681693

Rheumatoid arthritis-associated interstitial lung disease: epidemiology, risk/prognostic factors, and treatment landscape.

Fazeli MS, Khaychuk V, Wittstock K, Han X, Crocket G, Lin M, Hill SL, Ferri L.

Clin Exp Rheumatol. 2021 Feb 26. Online ahead of print.

PMID: 33635222

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma.

Munshi NC, Anderson LD Jr, Shah N, Madduri D, Berdeja J, Lonial S, Raje N, Lin Y, Siegel D, Oriol A, Moreau P, Yakoub-Agha I, Delforge M, Cavo M, Einsele H, Goldschmidt H, Weisel K, Rambaldi A, Reece D, Petrocca F, Massaro M, Connarn JN, Kaiser S, Patel P, Huang L, Campbell TB, Hege K, San-Miguel J.

N Engl J Med. 2021 Feb 25;384(8):705-716. doi: 10.1056/NEJMoa2024850.

PMID: 33626253

Productivity improvement and charge variant modulation for intensified cell culture processes by adding a carboxypeptidase B (CpB) treatment step.

Xu J, Zheng S, Dawood Z, Hill C, Jin W, Xu X, Ding J, Borys MC, Ghose S, Li ZJ, Pendse G.

Biotechnol Bioeng. 2021 Feb 24. doi: 10.1002/bit.27723. Online ahead of print.

PMID: 33624836

Thoracic Lymph Duct Catheterization with a Venous Shunt in the Nonhuman Primate.

Ehrmann J, Generaux C, Ostergaard S, Johnson W, Rose A, Mendenhall V.

J Invest Surg. 2021 Feb 23:1-9. doi: 10.1080/08941939.2021.1874081. Online ahead of print.

PMID: 33622163

Haemodynamic effects of the nitroxyl donor cimlanod (BMS-986231) in chronic heart failure: a randomized trial.

Lang NN, Ahmad FA, Cleland JG, O'Connor CM, Teerlink JR, Voors AA, Taubel J, Hodes AR, Anwar M, Karra R, Sakata Y, Ishihara S, Senior R, Khemka A, Prasad NG, DeSouza MM, Seiffert D, Ye JY, Kessler PD, Borentain M, Solomon SD, Felker GM, McMurray JJV.

Eur J Heart Fail. 2021 Feb 23. doi: 10.1002/ejhf.2138. Online ahead of print.

PMID: 33620131

Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1.

Degnan AP, Kumi GK, Allard CW, Araujo EV, Johnson WL, Zimmermann K, Pearce BC, Sheriff S, Futran A, Li X, Locke GA, You D, Morrison J, Parrish KE, Stromko C, Murtaza A, Liu J, Johnson BM, Vite GD, Wittman MD.

ACS Med Chem Lett. 2021 Feb 19;12(3):443-450. doi: 10.1021/acsmedchemlett.0c00660. eCollection 2021 Mar 11.

PMID: 33732413

Anti-BCMA CAR T administration in a relapsed and refractory multiple myeloma patient after COVID-19 infection: a case report.

Madduri D, Parekh S, Campbell TB, Neumann F, Petrocca F, Jagannath S.

J Med Case Rep. 2021 Feb 19;15(1):90. doi: 10.1186/s13256-020-02598-0.

PMID: 33608053

Efficacy and safety of subsequent molecular targeted therapy after immuno-checkpoint therapy, retrospective study of Japanese patients with metastatic renal cell carcinoma (AFTER I-O study).

Tomita Y, Kimura G, Fukasawa S, Numakura K, Sugiyama Y, Yamana K, Naito S, Kabu K, Tajima Y, Oya M.

Jpn J Clin Oncol. 2021 Feb 17:hyaa266. doi: 10.1093/jjco/hyaa266. Online ahead of print.

PMID: 33594427

CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia.

Hansen JD, Correa M, Alexander M, Nagy M, Huang D, Sapienza J, Lu G, LeBrun LA, Cathers BE, Zhang W, Tang Y, Ammirante M, Narla RK, Piccotti JR, Pourdehnad M, Lopez-Girona A.

J Med Chem. 2021 Feb 25;64(4):1835-1843. doi: 10.1021/acs.jmedchem.0c01489. Epub 2021 Feb 16.

PMID: 33591756

Ozanimod in relapsing multiple sclerosis: Pooled safety results from the clinical development program.

Selmaj KW, Cohen JA, Comi G, Bar-Or A, Arnold DL, Steinman L, Hartung HP, Montalban X, Havrdova EK, Cree BAC, Minton N, Sheffield JK, Ding N, Kappos L.

Mult Scler Relat Disord. 2021 Feb 15;51:102844. doi: 10.1016/j.msard.2021.102844. Online ahead of print.

PMID: 33892317

nab-Paclitaxel Plus Durvalumab in Patients With Previously Treated Advanced Stage Non-small Cell Lung Cancer (ABOUND.2L+).

Morgensztern D, Dols MC, Ponce Aix S, Postmus PE, Bennouna J, Fischer JR, Juan-Vidal O, Stewart DJ, Ardizzoni A, Bhore R, Wolfsteiner M, Reck M, Talbot D, Govindan R, Ong TJ.

Front Oncol. 2021 Feb 11;10:569715. doi: 10.3389/fonc.2020.569715. eCollection 2020.

PMID: 33643895

Bicyclic Ligand-Biased Agonists of S1P₁: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.

Gilmore JL, Xiao HY, Dhar TGM, Yang M, Xiao Z, Yang X, Taylor TL, McIntyre KW, Warrack BM, Shi H, Levesque PC, Marino AM, Cornelius G, Mathur A, Shen DR, Pang J, Cvijic ME, Lehman-McKeeman LD, Sun H, Xie J, Salter-Cid L, Carter PH, Dyckman AJ.

J Med Chem. 2021 Feb 11;64(3):1454-1480. doi: 10.1021/acs.jmedchem.0c01109. Epub 2021 Jan 25.

PMID: 33492963

DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody-Drug Conjugate Modality.

Sivaprakasam P, McDonald I, Iwuagwu C, Chowdari NS, Peese KM, Langley DR, Cheng H, Luzung MR, Schmidt MA, Zheng B, Tan Y, Cho P, Rakshit S, Lakshminarasimhan T, Guturi S, Kanagavel K, Kanusu U, Niyogi AG, Sidhar S, Vaidyanathan R, Eastgate MD, Kotapati S, Deshpande M, Pan C, Cardarelli PM, Xie C, Rao C, Holder P, Sarma G, Vite G, Gangwar S.

ACS Med Chem Lett. 2021 Feb 10;12(3):404-412. doi: 10.1021/acsmedchemlett.0c00578. eCollection 2021 Mar 11.

PMID: 33738068

Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction.

Hanff TC, Cohen JB, Zhao L, Javaheri A, Zamani P, Prenner SB, Rietzschel E, Jia Y, Walsh A, Maranville J, Wang Z, Adam L, Ramirez-Valle F, Schafer P, Seiffert D, Gordon DA, Cvijic ME, Cappola TP, Chirinos JA.

JACC Basic Transl Sci. 2021 Feb 10;6(2):89-99. doi: 10.1016/j.jacbts.2020.11.011. eCollection 2021 Feb.

PMID: 33665511

Correction To: Case Study in the Design of a Surrogate Solution for Use in Biopharmaceutical Drug Product Process Development.

Boksa K, Walsh P, Shah A.

AAPS PharmSciTech. 2021 Feb 10;22(2):70. doi: 10.1208/s12249-021-01935-w.

PMID: 33566206

To lie or not to lie: Super-relaxing with myosins.

Nag S, Trivedi DV.

Elife. 2021 Feb 10;10:e63703. doi: 10.7554/eLife.63703.

PMID: 33565963

Cardiovascular microphysiological systems (CVMPS) for safety studies - a pharma perspective.

Pointon A, Maher J, Davis M, Baker T, Cichocki J, Ramsden D, Hale C, Kolaja KL, Levesque P, Sura R, Stresser DM, Gintant G.

Lab Chip. 2021 Feb 9;21(3):458-472. doi: 10.1039/d0lc01040e.

PMID: 33471007

Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma.

Samur MK, Fulciniti M, Aktas Samur A, Bazarbachi AH, Tai YT, Prabhala R, Alonso A, Sperling AS, Campbell T, Petrocca F, Hege K, Kaiser S, Loiseau HA, Anderson KC, Munshi NC.

Nat Commun. 2021 Feb 8;12(1):868. doi: 10.1038/s41467-021-21177-5.

PMID: 33558511

Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma.

Bakouny Z, Braun DA, Shukla SA, Pan W, Gao X, Hou Y, Flaifel A, Tang S, Bosma-Moody A, He MX, Vokes N, Nyman J, Xie W, Nassar AH, Abou Alaiwi S, Flippot R, Bouchard G, Steinharter JA, Nuzzo PV, Ficial M, Sant'Angelo M, Forman J, Berchuck JE, Dudani S, Bi K, Park J, Camp S, Sticco-Ivins M, Hirsch L, Baca SC, Wind-Rotolo M, Ross-Macdonald P, Sun M, Lee GM, Chang SL, Wei XX, McGregor BA, Harshman LC, Genovese G, Ellis L, Pomerantz M, Hirsch MS, Freedman ML, Atkins MB, Wu CJ, Ho TH, Linehan WM, McDermott DF, Heng DYC, Viswanathan SR, Signoretti S, Van Allen EM, Choueiri TK.

Nat Commun. 2021 Feb 5;12(1):808. doi: 10.1038/s41467-021-21068-9.

PMID: 33547292

Outcomes in rheumatoid arthritis patients treated with abatacept: a UK multi-centre observational study.

Choy E, Groves L, Sugrue D, Hurst M, Houghton J, Venkatachalam S, Patel YI, Maxwell JR, Pollock KG, Henning S.

BMC Rheumatol. 2021 Feb 4;5(1):3. doi: 10.1186/s41927-020-00173-0.

PMID: 33536080

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.

Surka C, Jin L, Mbong N, Lu CC, Jang IS, Rychak E, Mendy D, Clayton T, Tindall E, Hsu C, Fontanillo C, Tran E, Contreras A, Ng SWK, Matyskiela M, Wang K, Chamberlain P, Cathers B, Carmichael J, Hansen J, Wang JCY, Minden MD, Fan J, Pierce DW, Pourdehnad M, Rolfe M, Lopez-Girona A, Dick JE, Lu G.

Blood. 2021 Feb 4;137(5):661-677. doi: 10.1182/blood.2020008676.

PMID: 33197925

TGFβ2 and TGFβ3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells.

Wang F, Zhang C, Kwagh J, Strassle B, Li J, Huang M, Song Y, Lehman B, Westhouse R, Palanisamy K, Holenarsipur VK, Borzilleri R, Augustine-Rauch K.

iScience. 2021 Feb 3;24(3):102133. doi: 10.1016/j.isci.2021.102133. eCollection 2021 Mar 19.

PMID: 33665554

Anti-HEV IgG Avidity Testing: Utility for Diagnosing Acute and Resolved Genotype 3 Infections.

Minosse C, Lapa D, Coppola A, Rapagna F, D'Offizi G, Taibi C, Lionetti R, Capobianchi MR, McPhee F, Garbuglia AR.

Viruses. 2021 Feb 3;13(2):236. doi: 10.3390/v13020236.

PMID: 33546482

Safety and efficacy of combination nivolumab plus ipilimumab in patients with advanced melanoma: results from a North American expanded access program (CheckMate 218).

Hodi FS, Chapman PB, Sznol M, Lao CD, Gonzalez R, Smylie M, Daniels GA, Thompson JA, Kudchadkar R, Sharfman W, Atkins M, Spigel DR, Pavlick A, Monzon J, Kim KB, Ernst S, Khushalani NI, van Dijck W, Lobo M, Hogg D.

Melanoma Res. 2021 Feb 1;31(1):67-75. doi: 10.1097/CMR.0000000000000708.

PMID: 33234846

Friend or Foe: Xenobiotic Activation of Nrf2 in Disease Control and Cardioprotection.

Hedrich WD, Wang H.

Pharm Res. 2021 Feb;38(2):213-241. doi: 10.1007/s11095-021-02997-y. Epub 2021 Feb 22.

PMID: 33619640

Characterizing tumor shrinkage as a measure of clinical benefit for immune checkpoint inhibitors.

Kelleher T, Cai J, Botwood NA, Labriola DF.

J Immunother Cancer. 2021 Feb;9(2):e001177. doi: 10.1136/jitc-2020-001177.

PMID: 33558277

Quantification of surrogate monoclonal antibodies in mouse serum using LC-MS/MS.

Mehl JT, Landry F, Discenza L, Sleczka B, Zhao Q, Shuster DJ, Madia P, DasGupta R, Rajendran S, Sun H, Ciccimaro E, Olah TV.

Bioanalysis. 2021 Feb;13(3):147-159. doi: 10.4155/bio-2020-0297. Epub 2021 Feb 5.

PMID: 33543654

The effectiveness of quality control samples in pharmaceutical bioanalysis.

Keller S, Quiroz J, Christopher D, Wickremsinhe E, Geng W, Hawthorne G, James C, Katterle Y, Li W, Liu G, Mayer A, Paton M, Pav J, Potter J, Vergis J, Wang J, Westcott-Baker L, Woolf E, Xue Y.

Bioanalysis. 2021 Feb;13(3):135-145. doi: 10.4155/bio-2020-0265. Epub 2021 Feb 4.

PMID: 33538614

Bayesian reaction optimization as a tool for chemical synthesis.

Shields BJ, Stevens J, Li J, Parasram M, Damani F, Alvarado JIM, Janey JM, Adams RP, Doyle AG.

Nature. 2021 Feb;590(7844):89-96. doi: 10.1038/s41586-021-03213-y. Epub 2021 Feb 3.

PMID: 33536653

Characteristics of Patients with Psoriasis Treated with Apremilast in the Corrona Psoriasis Registry.

Gottlieb AB, Merola JF, Cirulli J, Williams CC, Linowski GJ, Paris M, Litman HJ, Guo N, Emeanuru K, McLean RR, Cronin A, Strober B.

Dermatol Ther (Heidelb). 2021 Feb;11(1):253-263. doi: 10.1007/s13555-020-00479-4. Epub 2021 Jan 21.

PMID: 33475970

2020 White Paper on Recent Issues in Bioanalysis: BMV of Hybrid Assays, Acoustic MS, HRMS, Data Integrity, Endogenous Compounds, Microsampling and Microbiome (Part 1 - Recommendations on Industry/Regulators Consensus on BMV of Biotherapeutics by LCMS, Advanced Application in Hybrid Assays, Regulatory Challenges in Mass Spec, Innovation in Small Molecules, Peptides and Oligos).

Neubert H, Alley SC, Lee A, Jian W, Buonarati M, Edmison A, Garofolo F, Gorovits B, Haidar S, Mylott B, Nouri P, Qian M, Vinter S, Voelker T, Welink J, Wu J, Yang E, Yu H, Evans C, Summerfield S, Wang J, Bateman K, Boer J, Dean B, Dillen L, Faustino P, Ferrari L, Hughes N, Luo L, Olah T, Post N, Spellman DS, Sydor J, Zhang H, Zhang J, Zhang J, Fandozzi C, Wilson A, Fraier D, Beaver CJ, Dandamudi S, Dasgupta A, Elliott R, Ji A, Li W, McGuinness M, Lima Santos GM, Mirza T, Savoie N, Shakleya D, Sporring S, Stojdl S, Sundman P, Tampal N, Woolf E.

Bioanalysis. 2021 Feb;13(4):203-238. doi: 10.4155/bio-2020-0324. Epub 2021 Jan 20.

PMID: 33470871

First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial.

Paz-Ares L, Ciuleanu TE, Cobo M, Schenker M, Zurawski B, Menezes J, Richardet E, Bennouna J, Felip E, Juan-Vidal O, Alexandru A, Sakai H, Lingua A, Salman P, Souquet PJ, De Marchi P, Martin C, Pérol M, Scherpereel A, Lu S, John T, Carbone DP, Meadows-Shropshire S, Agrawal S, Oukessou A, Yan J, Reck M.

Lancet Oncol. 2021 Feb;22(2):198-211. doi: 10.1016/S1470-2045(20)30641-0. Epub 2021 Jan 18.

PMID: 33476593

Synthesis and Preclinical Evaluation of ⁶⁸Ga-labeled Adnectin, ⁶⁸Ga-BMS-986192 as a PET Agent for Imaging PD-L1 Expression.

Robu S, Richter A, Gosmann D, Seidl C, Leung D, Hayes W, Cohen D, Morin P, Donnelly DJ, Lipovšek D, Bonacorsi SJ, Smith A, Steiger K, Aulehner C, Krackhardt AM, Weber WA.

J Nucl Med. 2021 Jan 30:jnumed.120.258384. doi: 10.2967/jnumed.120.258384. Online ahead of print.

PMID: 33517324

Identification and characterization of 2^nd generation EZH2 inhibitors with extended residence times and improved biological activity.

Stuckey JI, Cantone NR, Côté A, Arora S, Vivat V, Ramakrishnan A, Mertz JA, Khanna A, Brenneman J, Gehling VS, Moine L, Sims RJ 3rd, Audia JE, Trojer P, Levell JR, Cummings RT.

J Biol Chem. 2021 Jan 29;296:100349. doi: 10.1016/j.jbc.2021.100349. Online ahead of print.

PMID: 33524394

Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.

Cherney EC, Zhang L, Nara S, Zhu X, Gullo-Brown J, Maley D, Lin TA, Hunt JT, Huang C, Yang Z, Darienzo C, Discenza L, Ranasinghe A, Grubb M, Ziemba T, Traeger SC, Li X, Johnston K, Kopcho L, Fereshteh M, Foster K, Stefanski K, Fargnoli J, Swanson J, Brown J, Delpy D, Seitz SP, Borzilleri R, Vite G, Balog A.

ACS Med Chem Lett. 2021 Jan 28;12(2):288-294. doi: 10.1021/acsmedchemlett.0c00668. eCollection 2021 Feb 11.

PMID: 33603977

Inhibition of MDM2 promotes anti-tumor responses in p53 wild-type cancer cells through their interaction with the immune and stromal microenvironment.

Wang HQ, Mulford IJ, Sharp F, Liang J, Kurtulus S, Trabucco G, Quinn DS, Longmire TA, Patel N, Patil R, Shirley MD, Chen Y, Wang H, Ruddy DA, Fabre C, Williams JA, Hammerman PS, Mataraza J, Platzer B, Halilovic E.

Cancer Res. 2021 Jan 27:canres.0189.2020. doi: 10.1158/0008-5472.CAN-20-0189. Online ahead of print.

PMID: 33504557

Clinical Benefit-Risk Assessment of Nivolumab 240 mg Every 2 Weeks in Chinese Patients With Advanced and Metastatic Solid Tumors.

Sheng J, Zhang J, Baudelet C, Roy A.

J Clin Pharmacol. 2021 Jan 27. doi: 10.1002/jcph.1821. Online ahead of print.

PMID: 33501654

nab-Paclitaxel/Carboplatin in Vulnerable Populations With Advanced Non-Small Cell Lung Cancer: Pooled Analysis.

Langer CJ, Gajra A, Gridelli C, Konduri K, Morgensztern D, Spigel D, Talbot D, Thomas M, Weiss J, Pilot R, Bhore R, Wolfsteiner M, Ong TJ, Socinski M.

Front Oncol. 2021 Jan 26;10:485587. doi: 10.3389/fonc.2020.485587. eCollection 2020.

PMID: 33575203

An innovative kinome platform to accelerate small-molecule inhibitor discovery and optimization from hits to leads.

Chaudhry C, Tebben A, Tokarski JS, Borzilleri R, Pitts WJ, Lippy J, Zhang L.

Drug Discov Today. 2021 Jan 23:S1359-6446(21)00048-9. doi: 10.1016/j.drudis.2021.01.018. Online ahead of print.

PMID: 33497831

Evaluating Treatment Patterns, Relapses, Healthcare Resource Utilization, and Costs Associated with Disease-Modifying Treatments for Multiple Sclerosis in DMT-Naïve Patients.

Freeman L, Kee A, Tian M, Mehta R.

Clinicoecon Outcomes Res. 2021 Jan 22;13:65-75. doi: 10.2147/CEOR.S288296. eCollection 2021.

PMID: 33519217

Best practices for artificial intelligence in life sciences research.

Makarov VA, Stouch T, Allgood B, Willis CD, Lynch N.

Drug Discov Today. 2021 Jan 22:S1359-6446(21)00047-7. doi: 10.1016/j.drudis.2021.01.017. Online ahead of print.

PMID: 33493454

End-to-end collaboration to transform biopharmaceutical development and manufacturing.

Erickson J, Baker J, Barrett S, Brady C, Brower M, Carbonell R, Charlebois T, Coffman J, Connell-Crowley L, Coolbaugh M, Fallon E, Garr E, Gillespie C, Hart R, Haug A, Nyberg G, Phillips M, Pollard D, Qadan M, Ramos I, Rogers K, Schaefer G, Walther J, Lee K.

Biotechnol Bioeng. 2021 Jan 22. doi: 10.1002/bit.27688. Online ahead of print.

PMID: 33480041

First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial.

Baas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Jahan T, Antonia S, Oulkhouir Y, Bautista Y, Cornelissen R, Greillier L, Grossi F, Kowalski D, Rodríguez-Cid J, Aanur P, Oukessou A, Baudelet C, Zalcman G.

Lancet. 2021 Jan 30;397(10272):375-386. doi: 10.1016/S0140-6736(20)32714-8. Epub 2021 Jan 21.

PMID: 33485464

Recurrent or progressive pediatric brain tumors: population pharmacokinetics and exposure-response analysis of pomalidomide.

Ogasawara K, Kassir N, Wang X, Benettaib B, Zhou S, Palmisano M, Li Y.

Pediatr Res. 2021 Jan 19. doi: 10.1038/s41390-020-01304-6. Online ahead of print.

PMID: 33469186

Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.

Gordin M, Philip H, Zilberberg A, Gidoni M, Margalit R, Clouser C, Adams K, Vigneault F, Cohen IR, Yaari G, Efroni S.

PLoS Comput Biol. 2021 Jan 19;17(1):e1008486. doi: 10.1371/journal.pcbi.1008486. eCollection 2021 Jan.

PMID: 33465095

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.

Lebeau PF, Wassef H, Byun JH, Platko K, Ason B, Jackson S, Dobroff J, Shetterly S, Richards WG, Al-Hashimi AA, Won KD, Mbikay M, Prat A, Tang A, Paré G, Pasqualini R, Seidah NG, Arap W, Chrétien M, Austin RC.

J Clin Invest. 2021 Jan 19;131(2):e128650. doi: 10.1172/JCI128650.

PMID: 33211673

An observational study of international normalized ratio control according to NICE criteria in patients with non-valvular atrial fibrillation: the SAIL Warfarin Out of Range Descriptors Study (SWORDS).

Harris DE, Thayer D, Wang T, Brooks C, Murley G, Gravenor M, Hill NR, Lister S, Halcox J.

Eur Heart J Cardiovasc Pharmacother. 2021 Jan 16;7(1):40-49. doi: 10.1093/ehjcvp/pvz071.

PMID: 31774502

Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma.

Gooding S, Ansari-Pour N, Towfic F, Ortiz Estévez M, Chamberlain PP, Tsai KT, Flynt E, Hirst M, Rozelle D, Dhiman P, Neri P, Ramasamy K, Bahlis N, Vyas P, Thakurta A.

Blood. 2021 Jan 14;137(2):232-237. doi: 10.1182/blood.2020007081.

PMID: 33443552

Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements.

Badkar AV, Gandhi RB, Davis SP, LaBarre MJ.

Drug Des Devel Ther. 2021 Jan 13;15:159-170. doi: 10.2147/DDDT.S287323. eCollection 2021.

PMID: 33469268

Long-Term Efficacy And Safety Of Ozanimod In Moderate-To-Severe Ulcerative Colitis: Results From The Open-Label Extension Of The Randomized, Phase 2 Touchstone Study.

Sandborn WJ, Feagan BG, Hanauer S, Vermeire S, Ghosh S, Liu WJ, Petersen A, Charles L, Huang V, Usiskin K, Wolf DC, D'Haens G.

J Crohns Colitis. 2021 Jan 13:jjab012. doi: 10.1093/ecco-jcc/jjab012. Online ahead of print.

PMID: 33438008

Risk of opportunistic infections in patients with rheumatoid arthritis initiating abatacept: cumulative clinical trial data.

Simon TA, Dong L, Winthrop KL.

Arthritis Res Ther. 2021 Jan 11;23(1):17. doi: 10.1186/s13075-020-02399-2.

PMID: 33430948

Pten Deficiency Leads To Proteasome Addiction, A Novel Vulnerability In Glioblastoma.

Benitez JA, Finlay D, Castanza A, Parisian AD, Ma J, Longobardi C, Campos A, Vadla R, Izurieta A, Scerra G, Koga T, Long T, Chavez L, Mesirov JP, Vuori K, Furnari F.

Neuro Oncol. 2021 Jan 11:noab001. doi: 10.1093/neuonc/noab001. Online ahead of print.

PMID: 33428749

Alterations of NK Cell Phenotype in the Disease Course of Multiple Myeloma.

Pazina T, MacFarlane AW 4th, Bernabei L, Dulaimi E, Kotcher R, Yam C, Bezman NA, Robbins MD, Ross EA, Campbell KS, Cohen AD.

Cancers (Basel). 2021 Jan 10;13(2):226. doi: 10.3390/cancers13020226.

PMID: 33435153

Continued insights into virus clearance validation across continuous capture chromatography.

Angelo JM, Potter K, Müller-Späth T, Xu X, Li ZJ, Ghose S.

Biotechnol Bioeng. 2021 Jan 9. doi: 10.1002/bit.27674. Online ahead of print.

PMID: 33421115

Effectiveness and Safety of Apixaban vs. Warfarin in Venous Thromboembolism Patients with Obesity and Morbid Obesity.

Cohen A, Sah J, Lee T, Rosenblatt L, Hlavacek P, Emir B, Keshishian A, Yuce H, Luo X.

J Clin Med. 2021 Jan 8;10(2):200. doi: 10.3390/jcm10020200.

PMID: 33429844

Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies.

Huang RY, Wang Y, Jhatakia AD, Deng AX, Bee C, Deshpande S, Rangan VS, Bezman N, Gudmundsson O, Chen G.

J Am Soc Mass Spectrom. 2021 Jan 8. doi: 10.1021/jasms.0c00399. Online ahead of print.

PMID: 33415981

Rapid single cell evaluation of human disease and disorder targets using REVEAL: SingleCell™.

Kumar N, Golhar R, Sharma KS, Holloway JL, Sarangi S, Neuhaus I, Walsh AM, Pitluk ZW.

BMC Genomics. 2021 Jan 6;22(1):5. doi: 10.1186/s12864-020-07300-8.

PMID: 33407110

Case Study in the Design of a Surrogate Solution for Use in Biopharmaceutical Drug Product Process Development.

Boksa K, Walsh P, Shah A.

AAPS PharmSciTech. 2021 Jan 6;22(1):32. doi: 10.1208/s12249-020-01881-z.

PMID: 33404995

Comparative efficacy and safety of adjuvant nivolumab versus other treatments in adults with resected melanoma: a systematic literature review and network meta-analysis.

Toor K, Middleton MR, Chan K, Amadi A, Moshyk A, Kotapati S.

BMC Cancer. 2021 Jan 5;21(1):3. doi: 10.1186/s12885-020-07538-1.

PMID: 33402121

Multisector Collaborations and Global Oncology: The Only Way Forward.

Blanchard C, Lubuzo B, Asirwa FC, Dlamini X, Msadabwe-Chikuni SC, Mwachiro M, Shyirambere C, Ruhangaza D, Milner DA Jr, Van Loon K, DeBoer R, Mtshali P, Dugan U, Baker E, Shulman LN.

JCO Glob Oncol. 2021 Jan;7:153-161. doi: 10.1200/GO.20.00492.

PMID: 33493021

A flow cytometric assay for HLA-DR expression on monocytes validated as a biomarker for enrollment in sepsis clinical trials.

Quadrini KJ, Patti-Diaz L, Maghsoudlou J, Cuomo J, Hedrick MN, McCloskey TW.

Cytometry B Clin Cytom. 2021 Jan;100(1):103-114. doi: 10.1002/cyto.b.21987. Epub 2021 Jan 12.

PMID: 33432735

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor.

You D, Hillerman S, Locke G, Chaudhry C, Stromko C, Murtaza A, Fan Y, Koenitzer J, Chen Y, Briceno S, Bhadra R, Duperret E, Gullo-Brown J, Gao C, Zhao D, Feder J, Curtin J, Degnan AP, Kumi G, Wittman M, Johnson BM, Parrish KE, Gokulrangan G, Morrison J, Quigley M, Hunt JT, Salter-Cid L, Lees E, Sanjuan MA, Liu J.

J Immunother Cancer. 2021 Jan;9(1):e001402. doi: 10.1136/jitc-2020-001402.

PMID: 33408094

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog.

Woicke J, Al-Haddawi MM, Bienvenu JG, Caverly Rae JM, Chanut FJ, Colman K, Cullen JM, Davis W, Fukuda R, Huisinga M, Walker UJ, Kai K, Kovi RC, Macri NP, Marxfeld HA, Nikula KJ, Pardo ID, Rosol TJ, Sharma AK, Singh BP, Tamura K, Thibodeau MS, Vezzali E, Vidal JD, Meseck EK.

Toxicol Pathol. 2021 Jan;49(1):5-109. doi: 10.1177/0192623320968181.

PMID: 33393871

CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study.

O'Hara MH, O'Reilly EM, Varadhachary G, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Mick R, Gherardini PF, Kitch LJ, Xu J, Samuel T, Karakunnel J, Fairchild J, Bucktrout S, LaVallee TM, Selinsky C, Till JE, Carpenter EL, Alanio C, Byrne KT, Chen RO, Trifan OC, Dugan U, Horak C, Hubbard-Lucey VM, Wherry EJ, Ibrahim R, Vonderheide RH.

Lancet Oncol. 2021 Jan;22(1):118-131. doi: 10.1016/S1470-2045(20)30532-5.

PMID: 33387490

Cost-effectiveness of nivolumab in squamous and non-squamous non-small cell lung cancer in Canada and Sweden: an update with 5-year data.

Chaudhary MA, Holmberg C, Lakhdari K, Smare C, Theriou C, Dale P, Penrod JR.

J Med Econ. 2021 Jan-Dec;24(1):607-619. doi: 10.1080/13696998.2021.1917139.

PMID: 33870833

The value of imaging and clinical outcomes in a phase II clinical trial of a lysophosphatidic acid receptor antagonist in idiopathic pulmonary fibrosis.

Kim GHJ, Goldin JG, Hayes W, Oh A, Soule B, Du S.

Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211004238. doi: 10.1177/17534666211004238.

PMID: 33781141

Risk and cost of infection-related hospitalizations in medicare beneficiaries with comorbid rheumatoid arthritis treated with abatacept versus other targeted disease-modifying anti-rheumatic drugs.

Patel V, Pulungan Z, Shah A, Kambhampati M, Lobo F, Petrilla A.

J Med Econ. 2021 Jan-Dec;24(1):299-307. doi: 10.1080/13696998.2021.1881525.

PMID: 33502940

A comparison of mixture cure fraction models to traditional parametric survival models in estimation of the cost-effectiveness of nivolumab for relapsed small cell lung cancer.

Roth JA, Yuan Y, Othus M, Danese M, Wagner S, Penrod JR, Ramsey SD.

J Med Econ. 2021 Jan-Dec;24(1):79-86. doi: 10.1080/13696998.2020.1857960.

PMID: 33334176

Fate Mapping of Cancer Cells in Metastatic Lymph Nodes Using Photoconvertible Proteins.

Pereira ER, Kedrin D, Padera TP.

Methods Mol Biol. 2021;2265:363-376. doi: 10.1007/978-1-0716-1205-7_26.

PMID: 33704727

Block PD, Shinn B, Kim JH, Hann HW.

Hepat Oncol. 2020 Dec 29;8(1):HEP35. doi: 10.2217/hep-2020-0028.

PMID: 33680431

Measuring atropisomers of BMS-986142 using 2DLC as an enabling technology.

Wang Q, He BL, Shackman JG.

J Pharm Biomed Anal. 2021 Jan 30;193:113730. doi: 10.1016/j.jpba.2020.113730. Epub 2020 Oct 31.

PMID: 33181427

Electron-Passing Neural Networks for Atomic Charge Prediction in Systems with Arbitrary Molecular Charge.

Metcalf DP, Jiang A, Spronk SA, Cheney DL, Sherrill CD.

J Chem Inf Model. 2021 Jan 25;61(1):115-122. doi: 10.1021/acs.jcim.0c01071. Epub 2020 Dec 16.

PMID: 33326247

3D printed bilayer tablet with dual controlled drug release for tuberculosis treatment.

Ghanizadeh Tabriz A, Nandi U, Hurt AP, Hui HW, Karki S, Gong Y, Kumar S, Douroumis D.

Int J Pharm. 2021 Jan 25;593:120147. doi: 10.1016/j.ijpharm.2020.120147. Epub 2020 Dec 3.

PMID: 33278493

High-Throughput Therapeutic Antibody Interference-Free High-Resolution Mass Spectrometry Assay for Monitoring M-Proteins in Multiple Myeloma.

Santockyte R, Puig O, Zheng N, Ouyang Z, Titsch C, Zhang YJ, Pillutla R, Zeng J.

Anal Chem. 2021 Jan 19;93(2):834-842. doi: 10.1021/acs.analchem.0c03357. Epub 2020 Dec 10.

PMID: 33300779

T4-mediated rescue of aortic malformations in hypothyroid rats indicates maternal thyroid status can affect great vessel development.

Augustine-Rauch K, Liaw JJ, Graziano M.

Toxicol Appl Pharmacol. 2021 Jan 15;411:115367. doi: 10.1016/j.taap.2020.115367. Epub 2020 Dec 17.

PMID: 33340518

Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity.

Oderinde MS, Ramirez A, Dhar TGM, Cornelius LAM, Jorge C, Aulakh D, Sandhu B, Pawluczyk J, Sarjeant AA, Meanwell NA, Mathur A, Kempson J.

J Org Chem. 2021 Jan 15;86(2):1730-1747. doi: 10.1021/acs.joc.0c02547. Epub 2020 Dec 24.

PMID: 33356273

Neoadjuvant Therapy for Melanoma: A U.S. Food and Drug Administration-Melanoma Research Alliance Public Workshop.

Mueller KL, Theoret MR, Lemery SJ, Amiri-Kordestani L, Ariyan CE, Atkins MB, Berry DA, Blank CU, DeMichele AM, Forde PM, Ibrahim N, Keegan P, Mitchell TC, Moss RA, Robert C, Sridhara R, Taube JM, Tetzlaff MT, Wargo JA, Flaherty KT, Kaplan MJ, Topalian SL, Ward AF, Hurlbert MS.

Clin Cancer Res. 2021 Jan 15;27(2):394-401. doi: 10.1158/1078-0432.CCR-20-3285. Epub 2020 Nov 13.

PMID: 33188142

Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.

Liu C, Lin J, Langevine C, Smith D, Li J, Tokarski JS, Khan J, Ruzanov M, Strnad J, Zupa-Fernandez A, Cheng L, Gillooly KM, Shuster D, Zhang Y, Thankappan A, McIntyre KW, Chaudhry C, Elzinga PA, Chiney M, Chimalakonda A, Lombardo LJ, Macor JE, Carter PH, Burke JR, Weinstein DS.

J Med Chem. 2021 Jan 14;64(1):677-694. doi: 10.1021/acs.jmedchem.0c01698. Epub 2020 Dec 28.

PMID: 33370104

Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins.

Page CG, Cooper SJ, DeHovitz JS, Oblinsky DG, Biegasiewicz KF, Antropow AH, Armbrust KW, Ellis JM, Hamann LG, Horn EJ, Oberg KM, Scholes GD, Hyster TK.

J Am Chem Soc. 2021 Jan 13;143(1):97-102. doi: 10.1021/jacs.0c11462. Epub 2020 Dec 28.

PMID: 33369395

Data-smart machine learning methods for predicting composition-dependent Young's modulus of pharmaceutical compacts.

Thomas S, Palahnuk H, Amini H, Akseli I.

Int J Pharm. 2021 Jan 5;592:120049. doi: 10.1016/j.ijpharm.2020.120049. Epub 2020 Nov 7.

PMID: 33171260

A methodology employing retention modeling for achieving control space in liquid chromatography method development using quality by design approach.

Jayaraman K, Rajendran AK, Kumar GS, Bhutani H.

J Chromatogr A. 2021 Jan 4;1635:461658. doi: 10.1016/j.chroma.2020.461658. Epub 2020 Nov 4.

PMID: 33333351

Discovery of Annulating Reagents Enabling the One-Step and Highly Stereoselective Synthesis of Cyclopentyl and Cyclohexyl Cores.

McDaniel J, Farley CA, Ramirez A, Sandhu B, Sarjeant A, Shi Q, Han A, Gallagher WP, Hynes J Jr, Dhar TGM, Gonzalez-Bobes F, Coombs JR, Marcoux D.

Org Lett. 2021 Jan 1;23(1):60-65. doi: 10.1021/acs.orglett.0c03695. Epub 2020 Dec 22.

PMID: 33351641

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing.

Andrews BI, Antia FD, Brueggemeier SB, Diorazio LJ, Koenig SG, Kopach ME, Lee H, Olbrich M, Watson AL.

J Org Chem. 2021 Jan 1;86(1):49-61. doi: 10.1021/acs.joc.0c02291. Epub 2020 Nov 30.

PMID: 33253568

Phase I Study of Alvocidib Followed by 7+3 (Cytarabine + Daunorubicin) in Newly Diagnosed Acute Myeloid Leukemia.

Zeidner JF, Lee DJ, Frattini M, Fine GD, Costas J, Kolibaba K, Anthony SP, Bearss D, Smith BD.

Clin Cancer Res. 2021 Jan 1;27(1):60-69. doi: 10.1158/1078-0432.CCR-20-2649. Epub 2020 Sep 30.

PMID: 32998965

Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).

Lau WL, Pearce B, Malakian H, Rodrigo I, Xie D, Gao M, Marsilio F, Chang C, Ruzanov M, Muckelbauer JK, Newitt JA, Lipovšek D, Sheriff S.

Acta Crystallogr F Struct Biol Commun. 2021 Jan 1;77(Pt 1):22-28. doi: 10.1107/S2053230X20016015. Epub 2020 Dec 22.

PMID: 33439152

Profiling and targeting connective tissue remodeling in autoimmunity - A novel paradigm for diagnosing and treating chronic diseases.

Karsdal MA, Kraus VB, Shevell D, Bay-Jensen AC, Schattenberg J, Rambabu Surabattula R, Schuppan D.

Autoimmun Rev. 2021 Jan;20(1):102706. doi: 10.1016/j.autrev.2020.102706. Epub 2020 Nov 12.

PMID: 33188918

Biomarkers of response to ibrutinib plus nivolumab in relapsed diffuse large B-cell lymphoma, follicular lymphoma, or Richter's transformation.

Hodkinson BP, Schaffer M, Brody JD, Jurczak W, Carpio C, Ben-Yehuda D, Avivi I, Forslund A, Özcan M, Alvarez J, Ceulemans R, Fourneau N, Younes A, Balasubramanian S.

Transl Oncol. 2021 Jan;14(1):100977. doi: 10.1016/j.tranon.2020.100977. Epub 2020 Dec 6.

PMID: 33395752

Comparison of nab-paclitaxel plus gemcitabine in elderly versus younger patients with metastatic pancreatic cancer: Analysis of a multicentre, prospective, non-interventional study.

Prager GW, Oehler L, Gerger A, Mlineritsch B, Andel J, Petzer A, Wilthoner K, Sliwa T, Pichler P, Winder T, Heibl S, Gruenberger B, Laengle F, Hubmann E, Korger M, Pecherstorfer M, Djanani A, Neumann HJ, Philipp-Abbrederis K, Wöll E, Trondl R, Arnold-Schrauf C, Eisterer W.

Eur J Cancer. 2021 Jan;143:101-112. doi: 10.1016/j.ejca.2020.11.003. Epub 2020 Dec 6.

PMID: 33296830

Effective Pharmacovigilance System Development: EFPIA-IPVG Consensus Recommendations.

Peters T, Soanes N, Abbas M, Ahmad J, Delumeau JC, Herrero-Martinez E, Paramananda M, Piper J, Smail-Aoudia F, van der Spuij W, Veizovic T, Winstanley G;

EFPIA International Pharmacovigilance Group.Drug Saf. 2021 Jan;44(1):17-28. doi: 10.1007/s40264-020-01008-0. Epub 2020 Dec 8.

PMID: 33289904

Real-World Effectiveness of Nivolumab Monotherapy After Prior Systemic Therapy in Advanced Non-Small-Cell Lung Cancer in the United States.

Stenehjem DD, Lubinga SJ, Gupte-Singh K, Zhang Y, Le TK, Penrod JR, Smith CB.

Clin Lung Cancer. 2021 Jan;22(1):e35-e47. doi: 10.1016/j.cllc.2020.07.009. Epub 2020 Jul 29.

PMID: 33187914

Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study.

Adams D, Polydefkis M, González-Duarte A, Wixner J, Kristen AV, Schmidt HH, Berk JL, Losada López IA, Dispenzieri A, Quan D, Conceição IM, Slama MS, Gillmore JD, Kyriakides T, Ajroud-Driss S, Waddington-Cruz M, Mezei MM, Planté-Bordeneuve V, Attarian S, Mauricio E, Brannagan TH 3rd, Ueda M, Aldinc E, Wang JJ, White MT, Vest J, Berber E, Sweetser MT, Coelho T; patisiran Global OLE study group.

Lancet Neurol. 2021 Jan;20(1):49-59. doi: 10.1016/S1474-4422(20)30368-9. Epub 2020 Nov 16.

PMID: 33212063

2020 Publications

2019 Publications

Single-Dose Pharmacokinetics, Safety, and Tolerability of Avadomide (CC-122) in Subjects With Mild, Moderate, or Severe Renal Impairment.

Li Y, MacGorman K, Liu L, Chen J, Hoffmann M, Palmisano M, Zhou S.

Clin Pharmacol Drug Dev. 2019 Dec 31. doi: 10.1002/cpdd.760. [Epub ahead of print]

PMID: 31891240

Recent advances and optimal management of human epidermal growth factor receptor-2-positive early-stage breast cancer.

Batoo S, Bayraktar S, Al-Hattab E, Basu S, Okuno S, Glück S.

J Carcinog. 2019 Dec 31;18:5. doi: 10.4103/jcar.JCar_14_19. eCollection 2019. Review.

PMID: 31949426

Solid state nuclear magnetic resonance studies of hydroxypropylmethylcellulose acetyl succinate polymer, a useful carrier in pharmaceutical solid dispersions.

Pugliese A, Hawarden LE, Abraham A, Tobyn M, Blanc F.

Magn Reson Chem. 2019 Dec 27. doi: 10.1002/mrc.4984. [Epub ahead of print]

PMID: 31880823

Trajectories of health-related quality of life among renal transplant patients associated with graft failure and symptom distress: Analysis of the BENEFIT and BENEFIT-EXT trials.

Purnajo I, Beaumont JL, Polinsky M, Alemao E, Everly MJ.

Am J Transplant. 2019 Dec 24. doi: 10.1111/ajt.15757. [Epub ahead of print]

PMID: 31874117

Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial.

Sanyal A, Charles ED, Neuschwander-Tetri BA, Loomba R, Harrison SA, Abdelmalek MF, Lawitz EJ, Halegoua-DeMarzio D, Kundu S, Noviello S, Luo Y, Christian R.

Lancet. 2019 Dec 22;392(10165):2705-2717. doi: 10.1016/S0140-6736(18)31785-9. Epub 2018 Dec 13.

PMID: 30554783

Covariate adjustment for randomized controlled trials revisited.

Wang J.

Pharm Stat. 2019 Dec 21. doi: 10.1002/pst.1988. [Epub ahead of print]

PMID: 31863636

Inflammatory bowel disease - one entity with many molecular faces.

Szymańska S, Matuszczyk M, Osuch M, Meglicka M, Szymanska E, Bierła J, Kierkuś J.

Prz Gastroenterol. 2019 Dec 20;14(4):228-232. doi: 10.5114/pg.2019.90249. Epub 2019 Dec 20. Review.

PMID: 31988668

Cancer diagnosis and care among rural-to-urban migrants in China.

Myerson R, Lu T, Yuan Y, Liu GG.

BMJ Glob Health. 2019 Dec 18;4(6):e001923. doi: 10.1136/bmjgh-2019-001923. eCollection 2019.

PMID: 31908866

An Integrated Approach for Determining a Protein-Protein Binding Interface in Solution and an Evaluation of Hydrogen-Deuterium Exchange Kinetics for Adjudicating Candidate Docking Models.

Zhang MM, Beno BR, Huang RY, Adhikari J, Deyanova EG, Li J, Chen G, Gross ML.

Anal Chem. 2019 Dec 17;91(24):15709-15717. doi: 10.1021/acs.analchem.9b03879. Epub 2019 Nov 22.

PMID: 31710208

Cost-Effectiveness of Extended and One-Time Screening Versus No Screening for Non-Valvular Atrial Fibrillation in the USA.

Oguz M, Lanitis T, Li X, Wygant G, Singer DE, Friend K, Hlavacek P, Nikolaou A, Mattke S.

Appl Health Econ Health Policy. 2019 Dec 17. doi: 10.1007/s40258-019-00542-y. [Epub ahead of print]

PMID: 31849021

Nonhomologous end-joining repair is likely involved in the repair of double-stranded DNA breaks induced by riluzole in melanoma cells.

Cerchio R Jr, Marinaro C, Foo TK, Xia B, Chen S.

Melanoma Res. 2019 Dec 17. doi: 10.1097/CMR.0000000000000652. [Epub ahead of print]

PMID:31855905

Mongersen (GED-0301) for Active Crohn's Disease: Results of a Phase 3 Study.

Sands BE, Feagan BG, Sandborn WJ, Schreiber S, Peyrin-Biroulet L, Colombel JF, Rossiter G, Usiskin K, Ather S, Zhan X, DʼHaens G.

Am J Gastroenterol. 2019 Dec 16. doi: 10.14309/ajg.0000000000000493. [Epub ahead of print]

PMID: 31850931

Practical applications of bio-fluorescent particle counting in Environmental Monitoring investigations.

Prasad A, Villari P, Henry R', Weber J, Hauschild J, Yan L, Horsch J, Shereefa S, Rau JE, Milling A, Bolden JS, Plourde L, Claassen M, IJzerman-Boon P, Forng RY, Portmann R, Urwyler S, Dassu D.

PDA J Pharm Sci Technol. 2019 Dec 16. pii: pdajpst.2019.009969. doi: 10.5731/pdajpst.2019.009969. [Epub ahead of print]

PMID: 31843986

Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses.

Caetano MS, Younes AI, Barsoumian HB, Quigley M, Menon H, Gao C, Spires T, Reilly TP, Cadena AP, Cushman TR, Schoenhals JE, Li A, Nguyen QN, Cortez MA, Welsh JW.

Clin Cancer Res. 2019 Dec 15;25(24):7576-7584. doi: 10.1158/1078-0432.CCR-19-0795. Epub 2019 Sep 20.

PMID: 31540976

Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution.

Wu Y, Broadaway KA, Raulerson CK, Scott LJ, Pan C, Ko A, He A, Tilford C, Fuchsberger C, Locke AE, Stringham HM, Jackson AU, Narisu N, Kuusisto J, Pajukanta P, Collins FS, Boehnke M, Laakso M, Lusis AJ, Civelek M, Mohlke KL.

Hum Mol Genet. 2019 Dec 15;28(24):4161-4172. doi: 10.1093/hmg/ddz263.

PMID: 31691812

Adverse vacuolation in multiple tissues in cynomolgus monkeys following repeat-dose administration of a PEGylated protein.

Fletcher AM, Tellier P, Douville J, Mansell P, Graziano MJ, Mangipudy RS, Brodie TA, Achanzar WE.

Toxicol Lett. 2019 Dec 15;317:120-129. doi: 10.1016/j.toxlet.2019.09.023. Epub 2019 Sep 30.

PMID: 31580884

First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy.

Munster P, Mita M, Mahipal A, Nemunaitis J, Massard C, Mikkelsen T, Cruz C, Paz-Ares L, Hidalgo M, Rathkopf D, Blumenschein G Jr, Smith DC, Eichhorst B, Cloughesy T, Filvaroff EH, Li S, Raymon H, de Haan H, Hege K, Bendell JC.

Cancer Manag Res. 2019 Dec 13;11:10463-10476. doi: 10.2147/CMAR.S208720. eCollection 2019.

PMID: 31853198

First-Line Doublet Chemotherapy for Metastatic Triple-Negative Breast Cancer: Circulating Tumor Cell Analysis of the tnAcity Trial.

Liu MC, Janni W, Georgoulias V, Yardley DA, Harbeck N, Wei X, McGovern D, Beck R.

Cancer Manag Res. 2019 Dec 12;11:10427-10433. doi: 10.2147/CMAR.S208712. eCollection 2019.

PMID: 31849532

Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma.

Wang R, Zheng J, Shao X, Ishii Y, Roy A, Bello A, Lee R, Zhang J, Wind-Rotolo M, Feng Y.

J Immunother Cancer. 2019 Dec 11;7(1):348. doi: 10.1186/s40425-019-0819-2.

PMID: 31829287

An analysis of orphan medicine expenditure in Europe: is it sustainable?

Mestre-Ferrandiz J, Palaska C, Kelly T, Hutchings A, Parnaby A.

Orphanet J Rare Dis. 2019 Dec 11;14(1):287. doi: 10.1186/s13023-019-1246-7.

PMID: 31829218

Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo.

Stifter SA, Bhattacharyya N, Sawyer AJ, Cootes TA, Stambas J, Doyle SE, Feigenbaum L, Paul WE, Britton WJ, Sher A, Feng CG.

Cell Rep. 2019 Dec 10;29(11):3539-3550.e4. doi: 10.1016/j.celrep.2019.11.021.

PMID: 31825834

Treatment-Free Survival: A Novel Outcome Measure of the Effects of Immune Checkpoint Inhibition-A Pooled Analysis of Patients With Advanced Melanoma.

Regan MM, Werner L, Rao S, Gupte-Singh K, Hodi FS, Kirkwood JM, Kluger HM, Larkin J, Postow MA, Ritchings C, Sznol M, Tarhini AA, Wolchok JD, Atkins MB, McDermott DF.

J Clin Oncol. 2019 Dec 10;37(35):3350-3358. doi: 10.1200/JCO.19.00345. Epub 2019 Sep 9.

PMID: 31498030

Disease activity measures at baseline predict structural damage progression: data from the randomized, controlled AMPLE and AVERT trials.

Keystone EC, Ahmad HA, Yazici Y, Bergman MJ.

Rheumatology (Oxford). 2019 Dec 9. pii: kez455. doi: 10.1093/rheumatology/kez455. [Epub ahead of print]

PMID: 31819995

Prospective Study Evaluating Changes in Bone Quality in Premenopausal Women With Breast Cancer Undergoing Adjuvant Chemotherapy.

Hopson MB, Onishi M, Awad D, Buono D, Maurer M, Crew KD, Shane E, Hershman DL, Kalinsky K.

Clin Breast Cancer. 2019 Dec 5. pii: S1526-8209(19)30759-1. doi: 10.1016/j.clbc.2019.12.001. [Epub ahead of print]

PMID: 31926840

Prospective Study Evaluating Changes in Bone Quality in Premenopausal Women With Breast Cancer Undergoing Adjuvant Chemotherapy.

Hopson MB, Onishi M, Awad D, Buono D, Maurer M, Crew KD, Shane E, Hershman DL, Kalinsky K.

Clin Breast Cancer. 2019 Dec 5. pii: S1526-8209(19)30759-1. doi: 10.1016/j.clbc.2019.12.001. [Epub ahead of print]

PMID: 31926840

Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Coronary Syndrome Treated Medically or With Percutaneous Coronary Intervention or Undergoing Elective Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial.

Windecker S, Lopes RD, Massaro T, Jones-Burton C, Granger CB, Aronson R, Heizer G, Goodman SG, Darius H, Jones WS, Aschermann M, Brieger D, Cura F, Engstrøm T, Fridrich V, Halvorsen S, Huber K, Kang HJ, Leiva-Pons JL, Lewis BS, Malaga G, Meneveau N, Merkely B, Milicic D, Morais J, Potpara TS, Raev D, Sabaté M, de Waha-Thiele S, Welsh RC, Xavier D, Mehran R, Alexander JH; AUGUSTUS Investigators.

Circulation. 2019 Dec 3;140(23):1921-1932. doi: 10.1161/CIRCULATIONAHA.119.043308. Epub 2019 Sep 26.

PMID: 31557056

Hospitalization Among Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention Treated With Apixaban or Aspirin: Insights From the AUGUSTUS Trial.

Vora AN, Alexander JH, Wojdyla DM, Aronson R, Granger CB, Darius H, Windecker S, Mehran R, Averkov O, Budaj A, Kong DF, Kobalava Z, Mehta RH, Mirza Z, Guimaraes PO, Parkhomenko A, Quadros A, Thiele H, Goodman SG, Lopes RD.

Circulation. 2019 Dec 3;140(23):1960-1963. doi: 10.1161/CIRCULATIONAHA.119.043754. Epub 2019 Sep 25. No abstract available.

PMID: 31553201

Circulation. 2019 Dec 3;140(23):1921-1932. doi: 10.1161/CIRCULATIONAHA.119.043308. Epub 2019 Sep 26.

PMID: 31557056

Hospitalization Among Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention Treated With Apixaban or Aspirin: Insights From the AUGUSTUS Trial.

Circulation. 2019 Dec 3;140(23):1960-1963. doi: 10.1161/CIRCULATIONAHA.119.043754. Epub 2019 Sep 25. No abstract available.

PMID: 31553201

Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance.

Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, Uppaluri R, Koong AC, Giaccia A, Le QT.

J Clin Invest. 2019 Dec 2;129(12):5553-5567. doi: 10.1172/JCI129025.

PMID: 31710313

Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance.

Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, Uppaluri R, Koong AC, Giaccia A, Le QT.

J Clin Invest. 2019 Dec 2;129(12):5553-5567. doi: 10.1172/JCI129025.

PMID: 31710313

The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors.

Saab S, Chang OS, Nagaoka K, Hung MC, Yamaguchi H.

Am J Cancer Res. 2019 Dec 1;9(12):2719-2729. eCollection 2019.

PMID: 31911857

The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors.

Saab S, Chang OS, Nagaoka K, Hung MC, Yamaguchi H.

Am J Cancer Res. 2019 Dec 1;9(12):2719-2729. eCollection 2019.

PMID: 31911857

A generic method for intact and subunit level characterization of mAb charge variants by native mass spectrometry.

Leblanc Y, Faid V, Lauber MA, Wang Q, Bihoreau N, Chevreux G.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Dec 1;1133:121814. doi: 10.1016/j.jchromb.2019.121814. Epub 2019 Oct 16.

PMID: 31731217

The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study.

Garonzik S, Byon W, Myers E, Li X, Marchisin D, Murthy B.

Am J Cardiovasc Drugs. 2019 Dec;19(6):561-567. doi: 10.1007/s40256-019-00348-2.

PMID: 31030414

Toward Accelerated Authorization and Access to New Medicines for Juvenile Idiopathic Arthritis.

Schanberg LE, Ramanan AV, De Benedetti F, Beukelman T, Eakin GS, Del Gaizo V, Ringold S, Vesely R, Schrandt S, Jaki T, Bili A, Chung JB, De Bono S, Douglass W, Enejosa JV, Kanik KS, Knobe K, Kunder R, Leite-Schnell JC, Suehiro RM, Wong RL, Mieszkalski KL, Marrow LC, Siebenaler K, Fraulo E, Kimura Y.

Arthritis Rheumatol. 2019 Dec;71(12):1976-1984. doi: 10.1002/art.41043. Epub 2019 Nov 1.

PMID: 31313532

2019 White Paper On Recent Issues in Bioanalysis: FDA BMV Guidance, ICH M10 BMV Guideline and Regulatory Inputs (Part 2 - Recommendations on 2018 FDA BMV Guidance, 2019 ICH M10 BMV Draft Guideline and Regulatory Agencies' Input on Bioanalysis, Biomarkers and Immunogenicity).

Booth B, Stevenson L, Pillutla R, Buonarati M, Beaver C, Fraier D, Garofolo F, Haidar S, Islam R, James C, Kadavil J, Kavetska O, Li F, Satterwhite C, Savoie N, Subramaniam S, Tampal N, Thway T, Woolf E, Blaye OL, Andisik M, Briscoe C, Cape S, Dasgupta A, Fischer S, Haidar S, Hayes R, Kamerud J, Lima Santos GM, Nehls C, Soo C, Vinter S, Whale E, Xu K, Cho SJ, Edmison A, Kassim S, Rocha TC, Welink J, Amur S, Bandukwala A, Cherry E, Hopper S, Ishii-Watabe A, Kirshner S, Maher K, Pedras-Vasconcelos J, Saito Y, Saunders TS, Skibeli V, Verthelyi D, Wang YM, Yan H.

Bioanalysis. 2019 Dec;11(23):2099-2132. doi: 10.4155/bio-2019-0270. Epub 2019 Dec 9.

PMID: 31833782

2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 - Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62).

Piccoli S, Mehta D, Vitaliti A, Allinson J, Amur S, Eck S, Green C, Hedrick M, Hopper S, Ji A, Joyce A, Litwin V, Maher K, Mathews J, Peng K, Safavi A, Wang YM, Zhang Y, Amaravadi L, Palackal N, Thankamony S, Beaver C, Bame E, Emrich T, Grimaldi C, Haulenbeek J, Joyce A, Kakkanaiah V, Lanham D, Maher K, Mayer A, Trampont PC, Vermet L, Dakappagari N, Fleener C, Garofolo F, Rogers C, Tangri S, Xu Y, Liang M, Rajadhyaksha M, Richards S, Schweighardt B, Purushothama S, Baltrukonis D, Brumm J, Cherry E, Delcarpini J, Gleason C, Kirshner S, Kubiak R, Pan L, Partridge M, Pedras-Vasconcelos J, Qu Q, Skibeli V, Saunders TS, Staack RF, Stubenrauch K, Torri A, Verthelyi D, Yan H, Gorovits B, Palmer R, Milton M, Long B, Corsaro B, Farrokhi V, Fiscella M, Henderson N, Jawa V, McNally J, Murphy R, Waldner H, Yang TY.

Bioanalysis. 2019 Dec;11(24):2207-2244. doi: 10.4155/bio-2019-0271. Epub 2019 Dec 10.

PMID: 31820675

Exploratory biomarker assays: key assay parameters to evaluate in the face of evolving biomarker context-of-use.

Thankamony SP, Zhang Y.

Bioanalysis. 2019 Dec;11(23):2095-2097. doi: 10.4155/bio-2019-0223. Epub 2019 Nov 28. No abstract available.

PMID: 31777269

Development of a prognostic model for overall survival in multiple myeloma using the Connect_® MM Patient Registry.

Terebelo HR, Abonour R, Gasparetto CJ, Toomey K, Durie BGM, Hardin JW, Jagannath S, Wagner L, Narang M, Flick ED, Srinivasan S, Yue L, Kitali A, Agarwal A, Rifkin RM; CONNECT MM Registry Investigators.

Br J Haematol. 2019 Dec;187(5):602-614. doi: 10.1111/bjh.16139. Epub 2019 Aug 5.

PMID: 31382320

Myocardial Microvascular Dysfunction in Rheumatoid Arthritis_{Quantitation by 13N-Ammonia Positron Emission Tomography/Computed Tomography}.

Amigues I, Russo C, Giles JT, Tugcu A, Weinberg R, Bokhari S, Bathon JM.

Circ Cardiovasc Imaging. 2019 Dec;12(1):e007495. doi: 10.1161/CIRCIMAGING.117.007495.

PMID: 30636512

Population Pharmacokinetics of Nivolumab in Combination With Ipilimumab in Patients With Advanced Malignancies.

Zhang J, Sanghavi K, Shen J, Zhao X, Feng Y, Statkevich P, Sheng J, Roy A, Zhu L.

CPT Pharmacometrics Syst Pharmacol. 2019 Dec;8(12):962-970. doi: 10.1002/psp4.12476. Epub 2019 Dec 1.

PMID: 31710163

Antibodies to Modulate Surface Receptor Systems Are Often Bivalent and Must Compete in a Two-Dimensional Cell Contact Region.

Schmidt BJ, Bee C, Han M, Jing Y, Cheng Y, Tenney DJ, Leil TA.

CPT Pharmacometrics Syst Pharmacol. 2019 Dec;8(12):873-877. doi: 10.1002/psp4.12468. Epub 2019 Oct 23. No abstract available.

PMID: 31529681

The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study.

Garonzik S, Byon W, Myers E, Li X, Marchisin D, Murthy B.

Am J Cardiovasc Drugs. 2019 Dec;19(6):561-567. doi: 10.1007/s40256-019-00348-2.

PMID: 31030414

Toward Accelerated Authorization and Access to New Medicines for Juvenile Idiopathic Arthritis.

Arthritis Rheumatol. 2019 Dec;71(12):1976-1984. doi: 10.1002/art.41043. Epub 2019 Nov 1.

PMID: 31313532

Bioanalysis. 2019 Dec;11(23):2099-2132. doi: 10.4155/bio-2019-0270. Epub 2019 Dec 9.

PMID: 31833782

Bioanalysis. 2019 Dec;11(24):2207-2244. doi: 10.4155/bio-2019-0271. Epub 2019 Dec 10.

PMID: 31820675

Exploratory biomarker assays: key assay parameters to evaluate in the face of evolving biomarker context-of-use.

Thankamony SP, Zhang Y.

Bioanalysis. 2019 Dec;11(23):2095-2097. doi: 10.4155/bio-2019-0223. Epub 2019 Nov 28. No abstract available.

PMID: 31777269

Development of a prognostic model for overall survival in multiple myeloma using the Connect_® MM Patient Registry.

Br J Haematol. 2019 Dec;187(5):602-614. doi: 10.1111/bjh.16139. Epub 2019 Aug 5.

PMID: 31382320

Safety, effectiveness, and health care cost comparisons among elderly patients with venous thromboembolism prescribed warfarin or apixaban in the United States Medicare population.

Hlavacek P, Guo JD, Rosenblatt L, Keshishian A, Russ C, Mardekian J, Ferri M, Poretta T, Yuce H, McBane R.

Curr Med Res Opin. 2019 Dec;35(12):2043-2051. doi: 10.1080/03007995.2019.1653067. Epub 2019 Sep 3.

PMID: 31387467

Chemical and physical instabilities in manufacturing and storage of therapeutic proteins.

Krause ME, Sahin E.

Curr Opin Biotechnol. 2019 Dec;60:159-167. doi: 10.1016/j.copbio.2019.01.014. Epub 2019 Mar 9. Review.

PMID: 30861476

Early Access to Medicines Scheme: real-world data collection.

Pang H, Wang M, Kiff C, Soni M, Stein D, Tyas D.

Drug Discov Today. 2019 Dec;24(12):2231-2233. doi: 10.1016/j.drudis.2019.06.009. Epub 2019 Jun 19.

PMID: 31228615

Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice.

Schafer PH, Adams M, Horan G, Truzzi F, Marconi A, Pincelli C.

Drugs R D. 2019 Dec;19(4):329-338. doi: 10.1007/s40268-019-00284-1.

PMID: 31598889

Report of the European Society of Cardiology Cardiovascular Round Table regulatory workshop update of the evaluation of new agents for the treatment of acute coronary syndrome: Executive summary.

Bueno H, de Graeff P, Richard-Lordereau I, Emmerich J, Fox KA, Friedman CP, Gaudin C, El-Gazayerly A, Goldman S, Hemmrich M, Henderson RA, Himmelmann A, Irs A, Jackson N, James SK, Katus HA, Laslop A, Laws I, Mehran R, Ong S, Prasad K, Roffi M, Rosano GM, Rose M, Sinnaeve PR, Stough WG, Thygesen K, Van de Werf F, Varin C, Verheugt FW, de Los Angeles Alonso García M.

Eur Heart J Acute Cardiovasc Care. 2019 Dec;8(8):745-754. doi: 10.1177/2048872616649859. Epub 2016 Jun 29.

PMID: 27357206

Phase II study of CC-486 (oral azacitidine) in previously treated patients with locally advanced or metastatic nasopharyngeal carcinoma.

Mesia R, Bossi P, Hansen AR, Hsieh CY, Licitra LF, Tan EH, Chen P, Miller J, Siu LL, Haddad RI.

Eur J Cancer. 2019 Dec;123:138-145. doi: 10.1016/j.ejca.2019.10.002. Epub 2019 Nov 4.

PMID: 31698327

Considering B7-CD28 as a family through sequence and structure.

West SM, Deng XA.

Exp Biol Med (Maywood). 2019 Dec;244(17):1577-1583. doi: 10.1177/1535370219855970. Epub 2019 Jun 17. No abstract available.

PMID: 31208204

Lenalidomide maintenance post-transplantation in newly diagnosed multiple myeloma: real-world outcomes and costs.

Hari P, Ung B, Abouzaid S, Agarwal A, Parikh K.

Future Oncol. 2019 Dec;15(35):4045-4056. doi: 10.2217/fon-2019-0422. Epub 2019 Oct 18.

PMID: 31625415

Factors to Consider in Development of Drugs for Pediatric Nonalcoholic Fatty Liver Disease.

Vos MB, Dimick-Santos L, Mehta R, Omokaro SO, Taminiau J, Schabel E, Kleiner DE, Szitanyi P, Socha P, Schwimmer JB, Noviello S, Silberg DG, Torstenson R, Miller V, Lavine JE; Liver Forum Pediatric Working Group.

Gastroenterology. 2019 Dec;157(6):1448-1456.e1. doi: 10.1053/j.gastro.2019.08.048. Epub 2019 Sep 12. No abstract available.

PMID: 31520612

Improving health determinants outside of the clinic does not mean outside of clinical science.

Smith T, Mattingly TJ, Slabaugh L.

Healthc (Amst). 2019 Dec;7(4). pii: S2213-0764(19)30148-4. doi: 10.1016/j.hjdsi.2019.06.001. Epub 2019 Jun 27.

PMID: 31257162

Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor.

Li KS, Schaper Bergman ET, Beno BR, Huang RY, Deyanova E, Chen G, Gross ML.

J Am Soc Mass Spectrom. 2019 Dec;30(12):2795-2804. doi: 10.1007/s13361-019-02316-1. Epub 2019 Nov 12.

PMID: 31720974

Drug-Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC-122) in Healthy Adult Subjects.

Ogasawara K, MacGorman K, Liu L, Chen J, Carayannopoulos LN, Zhou S, Palmisano M, Li Y.

J Clin Pharmacol. 2019 Dec;59(12):1620-1631. doi: 10.1002/jcph.1453. Epub 2019 Jun 6.

PMID: 31172535

Adjuvant therapy with nivolumab versus ipilimumab after complete resection of stage III/IV melanoma: Japanese subgroup analysis from the phase 3 CheckMate 238 study.

Yokota K, Uchi H, Uhara H, Yoshikawa S, Takenouchi T, Inozume T, Ozawa K, Ihn H, Fujisawa Y, Qureshi A, de Pril V, Otsuka Y, Weber J, Yamazaki N.

J Dermatol. 2019 Dec;46(12):1197-1201. doi: 10.1111/1346-8138.15103. Epub 2019 Oct 22.

PMID: 31638282

Apremilast mechanism of efficacy in systemic-naive patients with moderate plaque psoriasis: Pharmacodynamic results from the UNVEIL study.

Strober B, Alikhan A, Lockshin B, Shi R, Cirulli J, Schafer P.

J Dermatol Sci. 2019 Dec;96(3):126-133. doi: 10.1016/j.jdermsci.2019.09.003. Epub 2019 Sep 10.

PMID: 31787506

Qualitative analysis and reproducibility assessment of the Scalp Itch Numeric Rating Scale among patients with moderate to severe plaque psoriasis of the scalp.

Wang Y, Coyne K, Sofen H, Santanello N, Currie B, Zhang Z, Nograles K.

J Dermatolog Treat. 2019 Dec;30(8):775-783. doi: 10.1080/09546634.2019.1577546. Epub 2019 Mar 5.

PMID: 30747550

Corrigendum to "Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis" [J Hepatol 71 (2019) 543-552].

Yau T, Hsu C, Kim TY, Choo SP, Kang YK, Hou MM, Numata K, Yeo W, Chopra A, Ikeda M, Kuromatsu R, Moriguchi M, Chao Y, Zhao H, Anderson J, Dela Cruz C, Kudo M.

J Hepatol. 2019 Dec;71(6):1278. doi: 10.1016/j.jhep.2019.09.013. Epub 2019 Oct 25. No abstract available.

PMID: 31668671

Meeting Report of the 34th Annual Meeting of the Academy of Surgical Research: Summary of Presentations, Labs, and Workshops, Focusing on Experimental Surgery, Charleston, SC, September 26-28, 2018.

Graham ML, Stoll LJ, Ehrmann J.

J Invest Surg. 2019 Dec;32(8):773-784. doi: 10.1080/08941939.2019.1649767. Epub 2019 Aug 28.

PMID: 31455106

Total costs of treating venous thromboembolism: implication of different cost perspectives in a Danish setting.

Nielsen A, Poulsen PB, Dybro L, Kloster B, Lorentzen A, Olsen J, Kümler T.

J Med Econ. 2019 Dec;22(12):1321-1327. doi: 10.1080/13696998.2019.1668193. Epub 2019 Sep 27.

PMID: 31516054

Assessing an ASCO Decision Aid for Improving the Accuracy and Attribution of Serious Adverse Event Reporting From Investigators to Sponsors.

Mileham KF, Schenkel C, Chuk MK, Buchmeier A, Perez RP, Hurley P, Levit LA, Garrett-Mayer E, Davis C, Bruinooge SS, Vose J.

J Oncol Pract. 2019 Dec;15(12):e1050-e1065. doi: 10.1200/JOP.19.00366. Epub 2019 Oct 24.

PMID: 31647695

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