Research Publications

Our researchers, scientists and clinical partners are active members of the scientific community and have published their work in well-respected, peer-reviewed journals.
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2018 Publications

A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.

Schadt S, Bister B, Chowdhury SK, Funk C, Hop CECA, Humphreys WG, Igarashi F, James AD, Kagan M, Khojasteh SC, Nedderman ANR, Prakash C, Runge F, Scheible H, Spracklin DK, Swart P, Tse S, Yuan J, Obach RS.

Drug Metab Dispos. 2018 Jun;46(6):865-878. doi: 10.1124/dmd.117.079848. Epub 2018 Feb 27.

PMID: 29487142

 

Assessment of pre-operative maropitant citrate use in macaque (Macaca fasicularis & Macaca mulatta) neurosurgical procedures.

Steinbach JR, MacGuire J, Chang S, Dierks E, Roble GS.

J Med Primatol. 2018 Jun;47(3):178-184. doi: 10.1111/jmp.12343. Epub 2018 Apr 2.

PMID: 29611200

 

Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approach.

Chilton ML, Macmillan DS, Steger-Hartmann T, Hillegass J, Bellion P, Vuorinen A, Etter S, Smith BPC, White A, Sterchele P, De Smedt A, Glogovac M, Glowienke S, O'Brien D, Parakhia R.

Regul Toxicol Pharmacol. 2018 Jun;95:227-235. doi: 10.1016/j.yrtph.2018.03.015. Epub 2018 Mar 24

PMID: 29580972

 

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

Chen Y, Sit SY, Chen J, Swidorski JJ, Liu Z, Sin N, Venables BL, Parker DD, Nowicka-Sans B, Lin Z, Li Z, Terry BJ, Protack T, Rahematpura S, Hanumegowda U, Jenkins S, Krystal M, Dicker ID, Meanwell NA, Regueiro-Ren A.

Bioorg Med Chem Lett. 2018 May 15;28(9):1550-1557. doi: 10.1016/j.bmcl.2018.03.067. Epub 2018 Mar 26.

PMID: 29631960

 

canvasDesigner: A versatile interactive high-resolution scientific multi-panel visualization toolkit.

Zhang B, Zhao S, Neuhaus I.

Bioinformatics. 2018 May 3. doi: 10.1093/bioinformatics/bty377. [Epub ahead of print]

PMID: 29726919

 

Peri-operative Adverse Outcomes in Patients with Atrial Fibrillation Taking Warfarin or Edoxaban: Analysis of the ENGAGE AF-TIMI 48 Trial.

Douketis JD, Murphy SA, Antman EM, Grip LT, Mercuri MF, Ruff CT, Weitz JI, Braunwald E, Giugliano RP.

Thromb Haemost. 2018 May 3. doi: 10.1055/s-0038-1645856. [Epub ahead of print]

PMID: 29723874

 

Long-term treatment with atazanavir (ATV) in real life in Belgium: a retrospective observational cohort of 2264 HIV patients.

De Wit S, Florence E, Vandekerkhove L, Goffard JC, Vandercam B, Van Wijngaerden E, Moutschen M, Demeester R, Lacor P, Delforge M, van Frankenhuijsen M, Lacante P.

Acta Clin Belg. 2018 May 2:1-8. doi: 10.1080/17843286.2018.1462753. [Epub ahead of print]

PMID: 29718781

 

First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects.

Perera V, Luettgen JM, Wang Z, Frost CE, Yones C, Russo C, Lee J, Zhao Y, LaCreta FP, Ma X, Knabb RM, Seiffert D, DeSouza M, Mugnier P, Cirincione B, Ueno T, Frost RJA.

Br J Clin Pharmacol. 2018 May;84(5):876-887. doi: 10.1111/bcp.13520. Epub 2018 Mar 5.

PMID: 29346838

 

 All-Cause, Stroke/Systemic Embolism-, and Major Bleeding-Related Health-Care Costs Among Elderly Patients With Nonvalvular Atrial Fibrillation Treated With Oral Anticoagulants.

Deitelzweig S, Luo X, Gupta K, Trocio J, Mardekian J, Curtice T, Hlavacek P, Lingohr-Smith M, Menges B, Lin J.

Clin Appl Thromb Hemost. 2018 May;24(4):602-611. doi: 10.1177/1076029617750269. Epub 2018 Jan 24.

 PMID: 29363999

 

Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope.

Evangelista F, Roth AJ, Prisayanh P, Temple BR, Li N, Qian Y, Culton DA, Liu Z, Harrison OJ, Brasch J, Honig B, Shapiro L, Diaz LA.

J Autoimmun. 2018 May;89:171-185. doi: 10.1016/j.jaut.2017.12.017. Epub 2018 Jan 4.

PMID: 29307589

 

Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial.

Gore L, Kearns PR, de Martino ML, Lee, De Souza CA, Bertrand Y, Hijiya N, Stork LC, Chung NG, Cardos RC, Saikia T, Fagioli F, Seo JJ, Landman-Parker J, Lancaster D, Place AE, Rabin KR, Sacchi M, Swanink R, Zwaan CM.

J Clin Oncol. 2018 May 1;36(13):1330-1338. doi: 10.1200/JCO.2017.75.9597. Epub 2018 Mar 2.

PMID: 29498925

 

Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.

Chen XQ, Ziemba T, Huang C, Chang M, Xu C, Qiao JX, Wang TC, Finlay HJ, Salvati ME, Adam LP, Gudmundsson O, Hageman MJ.

J Pharm Sci. 2018 May;107(5):1352-1360. doi: 10.1016/j.xphs.2018.01.003. Epub 2018 Jan 6.

PMID: 29317226

 

Predicting Protein-Protein Interactions of Concentrated Antibody Solutions Using Dilute Solution Data and Coarse-Grained Molecular Models.

Calero-Rubio C, Ghosh R, Saluja A, Roberts CJ.

J Pharm Sci. 2018 May;107(5):1269-1281. doi: 10.1016/j.xphs.2017.12.015. Epub 2017 Dec 21.

PMID: 29274822

 

Phase 1/2 Study of the Safety and Tolerability of Nivolumab Plus Crizotinib for the First-Line Treatment of Anaplastic Lymphoma Kinase Translocation - Positive Advanced Non-Small Cell Lung Cancer (CheckMate 370).

Spigel DR, Reynolds C, Waterhouse D, Garon EB, Chandler J, Babu S, Thurmes P, Spira A, Jotte R, Zhu J, Lin WH, Blumenschein G Jr..

J Thorac Oncol. 2018 May;13(5):682-688. doi: 10.1016/j.jtho.2018.02.022. Epub 2018 Mar 6.

PMID: 29518553

 

Long-term follow-up of clinical trial patients treated for chronic HCV infection with daclatasvir-based regimens.

Reddy KR, Pol S, Thuluvath PJ, Kumada H, Toyota J, Chayama K, Levin J, Lawitz EJ, Gadano A, Ghesquiere W, Gerken G, Brunetto MR, Peng CY, Silva M, Strasser SI, Heo J, McPhee F, Liu Z, Yang R, Linaberry M, Noviello S.

Liver Int. 2018 May;38(5):821-833. doi: 10.1111/liv.13596. Epub 2017 Oct 12.

PMID: 28941023

 

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE.

Wang S, Wang J, Kumar V, Karnell JL, Naiman B, Gross PS, Rahman S, Zerrouki K, Hanna R, Morehouse C, Holoweckyj N, Liu H; Autoimmunity Molecular Medicine Team, Manna Z, Goldbach-Mansky R, Hasni S, Siegel R, Sanjuan M, Streicher K, Cancro MP, Kolbeck R, Ettinger R.

Nat Commun. 2018 May 1;9(1):1758. doi: 10.1038/s41467-018-03750-7.

PMID: 29717110

 

Discontinuation risk comparison among 'real-world' newly anticoagulated atrial fibrillation patients: Apixaban, warfarin, dabigatran, or rivaroxaban.

Lip GYH, Pan X, Kamble S, Kawabata H, Mardekian J, Masseria C, Phatak H.

PLoS One. 2018 Apr 30;13(4):e0195950. doi: 10.1371/journal.pone.0195950. eCollection 2018.

PMID: 29709012

 

Surface plasmon resonance as a tool for ligand-binding assay reagent characterization in bioanalysis of biotherapeutics.

Duo J, Bruno J, Kozhich A, David-Brown D, Luo L, Kwok S, Santockyte R, Haulenbeek J, Liu R, Hamuro L, Peterson JE, Piccoli S, DeSilva B, Pillutla R, Zhang YJ.

Bioanalysis. 2018 Apr 27. doi: 10.4155/bio-2017-0271. [Epub ahead of print]

PMID: 29701071

 

Drug-induced cholestasis: mechanisms, models, and markers.

Chatterjee S, Annaert P.

Curr Drug Metab. 2018 Apr 27. doi: 10.2174/1389200219666180427165035. [Epub ahead of print]

PMID: 29708070

 

Gradient elution behavior of proteins in hydrophobic interaction chromatography with U-shaped retention factor curves.

Creasy A, Lomino J, Barker G, Khetan A, Carta G.

J Chromatogr A. 2018 Apr 27;1547:53-61. doi: 10.1016/j.chroma.2018.03.012. Epub 2018 Mar 9.

PMID: 29551240

 

The expanding role of prodrugs in contemporary drug design and development.

Rautio J, Meanwell NA, Di L, Hageman MJ.

Nat Rev Drug Discov. 2018 Apr 27. doi: 10.1038/nrd.2018.46. [Epub ahead of print] Review.

PMID: 29700501

 

Cross-Site Reliability of Human Induced Pluripotent Stem-Cell Derived Cardiomyocyte Based Safety Assays using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study.

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G.

Toxicol Sci. 2018 Apr 27. doi: 10.1093/toxsci/kfy110. [Epub ahead of print]

PMID: 29718449

 

Abundance of Phase I and II Drug Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.

Prasad B, Bhatt DK, Johnson K, Chapa R, Chu X, Salphati L, Xiao G, Lee C, Hop CE, Mathias A, Lai Y, Liao M, Humphreys WG, Kumer SC, Unadkat JD.

Drug Metab Dispos. 2018 Apr 25. pii: dmd.118.080523. doi: 10.1124/dmd.118.080523. [Epub ahead of print]

PMID: 29695616

 

Monitoring of multiple solvent induced form changes during high shear wet granulation and drying processes using online Raman spectroscopy.

Reddy JP, Jones JW, Wray PS, Dennis AB, Brown J, Timmins P.

Int J Pharm. 2018 Apr 25;541(1-2):253-260. doi: 10.1016/j.ijpharm.2018.02.021. Epub 2018 Feb 24.

PMID: 29481947

 

Generic Anti-PEG Antibody Assay on ProterixBio's (Formerly BioScale) ViBE Platform Shows Poor Reproducibility.

Chilewski SD, Shields J, Mora JR, Myler H.

AAPS J. 2018 Apr 24;20(3):65. doi: 10.1208/s12248-018-0228-3.

PMID: 29691672

 

High-efficiency affinity precipitation of multiple industrial mAbs and Fc-fusion proteins from cell culture harvests using Z-ELP-E2 nanocages.

Swartz AR, Xu X, Traylor SJ, Li ZJ, Chen W.

Biotechnol Bioeng. 2018 Apr 21. doi: 10.1002/bit.26717. [Epub ahead of print]

PMID: 29679468

 

Leveraging a "Catch-Release" Logic Gate Process for the Synthesis and Nonchromatographic Purification of Thioether- or Amine-Bridged Macrocyclic Peptides.

Kheirabadi M, Creech GS, Qiao JX, Nirschl DS, Leahy DK, Boy KM, Carter PH, Eastgate MD.

J Org Chem. 2018 Apr 20;83(8):4323-4335. doi: 10.1021/acs.joc.7b03124. Epub 2018 Apr 3.

PMID: 29537839

 

An Elemental Impurities Excipient Database: A Viable Tool for ICH Q3D Drug Product Risk Assessment.

Boetzel R, Ceszlak A, Day C, Drumm P, Bejar JG, Glennon J, Harris L, Heghes CI, Horga R, Jacobs PL, Keurentjes WJTM, King F, Lee CW, Lewen N, Marchant CA, Maris FA, Nye W, Powell S, Rockstroh H, Rutter L, Schweitzer M, Shannon E, Smallshaw L, Teasdale A, Thompson S, Wilkinson D.

J Pharm Sci. 2018 Apr 18. pii: S0022-3549(18)30212-0. doi: 10.1016/j.xphs.2018.04.009. [Epub ahead of print]

PMID: 29679706

 

Implementation of Plate Imaging for Demonstration of Monoclonality in Biologics Manufacturing Development.

Zingaro K, Shaw D, Carson J, Mayer-Bartschmid A, Bender C, Alves C, McVey D, Quan NX, Wei Q, Laird M, Zhu Y, Emmins R, Follit J, Porter A, Racher AJ, Milne S, Carubelli I, Du Z, Khatri A, Failly M, Broly H, Lee F, Reeser M, Spirel J, Anderson K, DeMaria C, Di-Carlo J, Gill J, Lundquist A, Kumar SR, Gill T.

PDA J Pharm Sci Technol. 2018 Apr 18. pii: pdajpst.2018.008789. doi: 10.5731/pdajpst.2018.008789. [Epub ahead of print]

PMID: 29669815

 

Slow Off-Rate Modified Aptamer (SOMAmer) as a Novel Reagent in Immunoassay Development for Accurate Soluble Glypican-3 Quantification in Clinical Samples.

Duo J, Chiriac C, Huang RY, Mehl J, Chen G, Tymiak A, Sabbatini P, Pillutla R, Zhang Y.

Anal Chem. 2018 Apr 17;90(8):5162-5170. doi: 10.1021/acs.analchem.7b05277. Epub 2018 Apr 6.

PMID: 29605994

 

In silico toxicology protocols.

Myatt GJ, Ahlberg E, Akahori Y, Allen D, Amberg A, Anger LT, Aptula A, Auerbach S, Beilke L, Bellion P, Benigni R, Bercu J, Booth ED, Bower D, Brigo A, Burden N, Cammerer Z, Cronin MTD, Cross KP, Custer L, Dettwiler M, Dobo K, Ford KA, Fortin MC, Gad-McDonald SE, Gellatly N, Gervais V, Glover KP, Glowienke S, Van Gompel J, Gutsell S, Hardy B, Harvey JS, Hillegass J, Honma M, Hsieh JH, Hsu CW, Hughes K, Johnson C, Jolly R, Jones D, Kemper R, Kenyon MO, Kim MT, Kruhlak NL, Kulkarni SA, Kümmerer K, Leavitt P, Majer B, Masten S, Miller S, Moser J, Mumtaz M, Muster W, Neilson L, Oprea TI, Patlewicz G, Paulino A, Lo Piparo E, Powley M, Quigley DP, Reddy MV, Richarz AN, Ruiz P, Schilter B, Serafimova R, Simpson W, Stavitskaya L, Stidl R, Suarez-Rodriguez D, Szabo DT, Teasdale A, Trejo-Martin A, Valentin JP, Vuorinen A, Wall BA, Watts P, White AT, Wichard J, Witt KL, Woolley A, Woolley D, Zwickl C, Hasselgren C.

Regul Toxicol Pharmacol. 2018 Apr 17;96:1-17. doi: 10.1016/j.yrtph.2018.04.014. [Epub ahead of print]

PMID: 29678766

 

Predictive probability methods for interim monitoring in clinical trials with longitudinal outcomes.

Zhou M, Tang Q, Lang L, Xing J, Tatsuoka K.

Stat Med. 2018 Apr 17. doi: 10.1002/sim.7685. [Epub ahead of print]

PMID: 29664214

 

Bioinspired supramolecular engineering of self-assembling immunofibers for high affinity binding of immunoglobulin G.

Li Y, Lock LL, Wang Y, Ou SH, Stern D, Schön A, Freire E, Xu X, Ghose S, Li ZJ, Cui H.

Biomaterials. 2018 Apr 16. pii: S0142-9612(18)30287-4. doi: 10.1016/j.biomaterials.2018.04.032. [Epub ahead of print]

PMID: 29706234

 

Contributions of depth filter components to protein adsorption in bioprocessing.

Khanal O, Singh N, Traylor SJ, Xu X, Ghose S, Li ZJ, Lenhoff AM.

Biotechnol Bioeng. 2018 Apr 16. doi: 10.1002/bit.26707. [Epub ahead of print]

PMID: 29663326

 

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden.

Hellmann MD, Ciuleanu TE, Pluzanski A, Lee JS, Otterson GA, Audigier-Valette C, Minenza E, Linardou H, Burgers S, Salman P, Borghaei H, Ramalingam SS, Brahmer J, Reck M, O'Byrne KJ, Geese WJ, Green G, Chang H, Szustakowski J, Bhagavatheeswaran P, Healey D, Fu Y, Nathan F, Paz-Ares L.

N Engl J Med. 2018 Apr 16. doi: 10.1056/NEJMoa1801946. [Epub ahead of print]

PMID: 29658845

 

A three-point identity criteria tool for establishing product identity using icIEF method.

Ahluwalia D, Belakavadi M, Das TK, Katiyar A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;1083:271-277. doi: 10.1016/j.jchromb.2018.02.042. Epub 2018 Mar 1.

PMID: 29554523

 

Longterm Safety and Efficacy of Subcutaneous Abatacept in Patients with Rheumatoid Arthritis: 5-year Results from a Phase IIIb

Trial.

Genovese MC, Pacheco-Tena C, Covarrubias A, Leon G, Mysler E, Keiserman M, Valente RM, Nash P, Simon-Campos JA, Box J, Legerton CW 3rd, Nasonov E, Durez P, Elegbe A, Wong R, Li X, Banerjee S, Alten R.

J Rheumatol. 2018 Apr 15. pii: jrheum.170344. doi: 10.3899/jrheum.170344. [Epub ahead of print]

PMID: 29657147

 

Antibody dependent cellular phagocytosis by macrophages is a novel mechanism of action of elotuzumab.

Kurdi AT, Glavey SV, Bezman NA, Jhatakia A, Guerriero JL, Manier S, Moschetta M, Mishima Y, Roccaro A, Detappe A, Liu CJ, Sacco A, Huynh D, Tai YT, Robbins MD, Azzi J, Ghobrial IM.

Mol Cancer Ther. 2018 Apr 13. pii: molcanther.0998.2017. doi: 10.1158/1535-7163.MCT-17-0998. [Epub ahead of print]

PMID: 29654064

 

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.

Hellmann MD, Nathanson T, Rizvi H, Creelan BC, Sanchez-Vega F, Ahuja A, Ni A, Novik JB, Mangarin LMB, Abu-Akeel M, Liu C, Sauter JL, Rekhtman N, Chang E, Callahan MK, Chaft JE, Voss MH, Tenet M, Li XM, Covello K, Renninger A, Vitazka P, Geese WJ, Borghaei H, Rudin CM, Antonia SJ, Swanton C, Hammerbacher J, Merghoub T, McGranahan N, Snyder A, Wolchok JD.

Cancer Cell. 2018 Apr 12. pii: S1535-6108(18)30123-5. doi: 10.1016/j.ccell.2018.03.018. [Epub ahead of print]

PMID: 29657128

 

Meeting Report of the 33rd Annual Meeting of the Academy of Surgical Research: Summary of Presentations, Labs, and Workshops, Focusing on Experimental Surgery, Las Vegas, NV, October 4-6, 2017.

Graham ML, Ziegelhofer T, Ehrmann J.

J Invest Surg. 2018 Apr 11:1-13. doi: 10.1080/08941939.2018.1450911. [Epub ahead of print]

PMID: 29641265

 

A multi-arm phase I dose escalating study of an oral NOTCH inhibitor BMS-986115 in patients with advanced solid tumours.

Aung KL, El-Khoueiry AB, Gelmon K, Tran B, Bajaj G, He B, Chen T, Zhu L, Poojary S, Basak S, Qi Z, Spreafico A, Fischer BS, Desai J.

Invest New Drugs. 2018 Apr 10. doi: 10.1007/s10637-018-0597-6. [Epub ahead of print]

PMID: 29637471

 

Evaluation of General and Tailor Made Force Fields via X-ray Thermal Diffuse Scattering Using Molecular Dynamics and Monte Carlo Simulations of Crystalline Aspirin.

Chan EJ, Neumann MA.

J Chem Theory Comput. 2018 Apr 10;14(4):2165-2179. doi: 10.1021/acs.jctc.7b01073. Epub 2018 Mar 28.

PMID: 29513994

 

Nivolumab with or without ipilimumab in patients with recurrent glioblastoma: results from exploratory phase I cohorts of CheckMate 143.

Omuro A, Vlahovic G, Lim M, Sahebjam S, Baehring J, Cloughesy T, Voloschin A, Ramkissoon SH, Ligon KL, Latek R, Zwirtes R, Strauss L, Paliwal P, Harbison CT, Reardon DA, Sampson JH.

Neuro Oncol. 2018 Apr 9;20(5):674-686. doi: 10.1093/neuonc/nox208.

PMID: 29106665

 

 Simultaneous determination of trace concentrations of aldehydes and carboxylic acids in particulate matter.

Rousová J, Chintapalli MR, Lindahl A, Casey J, Kubátová A.

J Chromatogr A. 2018 Apr 6;1544:49-61. doi: 10.1016/j.chroma.2018.02.026. Epub 2018 Feb 18.

PMID: 29502899

 

P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.

Venables BL, Sin N, Wang AX, Sun LQ, Tu Y, Hernandez D, Sheaffer A, Lee M, Dunaj C, Zhai G, Barry D, Friborg J, Yu F, Knipe J, Sandquist J, Falk P, Parker D, Good AC, Rajamani R, McPhee F, Meanwell NA, Scola PM.

Bioorg Med Chem Lett. 2018 Apr 5. pii: S0960-894X(18)30307-X. doi: 10.1016/j.bmcl.2018.04.009. [Epub ahead of print]

PMID: 29650290

 

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma.

Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S, Powles T, Donskov F, Neiman V, Kollmannsberger CK, Salman P, Gurney H, Hawkins R, Ravaud A, Grimm MO, Bracarda S, Barrios CH, Tomita Y, Castellano D, Rini BI, Chen AC, Mekan S, McHenry MB, Wind-Rotolo M, Doan J, Sharma P, Hammers HJ, Escudier B; CheckMate 214 Investigators.

N Engl J Med. 2018 Apr 5;378(14):1277-1290. doi: 10.1056/NEJMoa1712126. Epub 2018 Mar 21.

PMID: 29562145

 

Performing studies using the UK Clinical Practice Research Datalink: to link or not to link?

McDonald L, Schultze A, Carroll R, Ramagopalan SV.

Eur J Epidemiol. 2018 Apr 4. doi: 10.1007/s10654-018-0389-5. [Epub ahead of print]

PMID: 29619668

 

Discovery, identification and mitigation of isobaric sulfate metabolite interference to a phosphate prodrug in LC-MS/MS bioanalysis: Critical role of method development in ensuring assay quality.

Yuan L, Ji QC.

J Pharm Biomed Anal. 2018 Apr 4;155:141-147. doi: 10.1016/j.jpba.2018.03.064. [Epub ahead of print]

PMID: 29631074

 

Control Strategy for Small Molecule Impurities in Antibody-Drug Conjugates.

Gong HH, Ihle N, Jones MT, Kelly K, Kott L, Raglione T, Whitlock S, Zhang Q, Zheng J.

AAPS PharmSciTech. 2018 Apr;19(3):971-977. doi: 10.1208/s12249-017-0943-6. Epub 2018 Jan 4.

PMID: 29302872

 

Nivolumab versus docetaxel in previously treated advanced non-small-cell lung cancer (CheckMate 017 and CheckMate 057): 3-year update and outcomes in patients with liver metastases.

Vokes EE, Ready N, Felip E, Horn L, Burgio MA, Antonia SJ, Arén Frontera O, Gettinger S, Holgado E, Spigel D, Waterhouse D, Domine M, Garassino M, Chow LQM, Blumenschein G Jr, Barlesi F, Coudert B, Gainor J, Arrieta O, Brahmer J, Butts C, Steins M, Geese WJ, Li A, Healey D, Crinò L.

Ann Oncol. 2018 Apr 1;29(4):959-965. doi: 10.1093/annonc/mdy041.

PMID: 29408986

 

Report on the 18th Annual Land O'Lakes Bioanalytical Conference.

Burns EC, Dhodda R, Pasas-Farmer S, Fluhler E, Guthrie R, Bennett P, Ji QC.

Bioanalysis. 2018 Apr 1;10(7):445-449. doi: 10.4155/bio-2018-4000. Epub 2018 Apr 10.

PMID: 29708430

 

Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.

Hu Z, Wang C, Han W, Rossi KA, Bozarth JM, Wu Y, Sheriff S, Myers JE Jr., Luettgen JM, Seiffert DA, Wexler RR, Quan ML.

Bioorg Med Chem Lett. 2018 Apr 1;28(6):987-992. doi: 10.1016/j.bmcl.2018.02.049. Epub 2018 Feb 27.

PMID: 29501396

 

Hypoxia and transforming growth factor-beta1 pathway activation promote Chinese Hamster Ovary cell aggregation.

Qian Y, Rehmann MS, Qian NX, He A, Borys MC, Kayne PS, Li ZJ.

Biotechnol Bioeng. 2018 Apr;115(4):1051-1061. doi: 10.1002/bit.26520. Epub 2018 Jan 8.

PMID: 29251349

 

Vitamin B12 association with mAbs: Mechanism and potential mitigation strategies.

Du C, Martin R, Huang Y, Borwankar A, Tan Z, West J, Singh N, Borys M, Ghose S, Ludwig R, Tao L, Li ZJ.

Biotechnol Bioeng. 2018 Apr;115(4):900-909. doi: 10.1002/bit.26511. Epub 2017 Dec 19.

PMID: 29205285

 

Safety profile of nivolumab administered as 30-min infusion: analysis of data from CheckMate 153.

Waterhouse D, Horn L, Reynolds C, Spigel D, Chandler J, Mekhail T, Mohamed M, Creelan B, Blankstein KB, Nikolinakos P, McCleod MJ, Li A, Oukessou A, Agrawal S, Aanur N.

Cancer Chemother Pharmacol. 2018 Apr;81(4):679-686. doi: 10.1007/s00280-018-3527-6. Epub 2018 Feb 13.

PMID: 29442139

 

Outcomes at 7 years post-transplant in black vs nonblack kidney transplant recipients administered belatacept or cyclosporine in BENEFIT and BENEFIT-EXT.

Florman S, Vincenti F, Durrbach A, Abouljoud M, Bresnahan B, Garcia VD, Mulloy L, Rice K, Rostaing L, Zayas C, Calderon K, Meier-Kriesche U, Polinsky M, Yang L, Medina Pestana J, Larsen CP.

Clin Transplant. 2018 Apr;32(4):e13225. doi: 10.1111/ctr.13225. Epub 2018 Mar 14.

PMID: 29461660

 

Changes in Heart Rate Associated with Exenatide Once Weekly: Pooled Analysis of Clinical Data in Patients with Type 2 Diabetes.

Marso SP, Hardy E, Han J, Wang H, Chilton RJ.

Diabetes Ther. 2018 Apr;9(2):551-564. doi: 10.1007/s13300-018-0370-z. Epub 2018 Feb 3.

PMID: 29397532

 

In-process rheometry as a PAT tool for hot melt extrusion.

Kelly AL, Gough T, Isreb M, Dhumal R, Jones JW, Nicholson S, Dennis AB, Paradkar A.

Drug Dev Ind Pharm. 2018 Apr;44(4):670-676. doi: 10.1080/03639045.2017.1408641. Epub 2017 Dec 4.

PMID: 29161918

 

LC-MS Differential Analysis for Fast and Sensitive Determination of Biotransformation of Therapeutic Proteins.

Yao M, Chen B, Zhao W, Mehl JT, Li L, Zhu M.

Drug Metab Dispos. 2018 Apr;46(4):451-457. doi: 10.1124/dmd.117.077792. Epub 2018 Jan 31.

PMID: 29386233

 

Antithrombotic therapy use and clinical outcomes following thrombo-embolic events in patients with atrial fibrillation: insights from ARISTOTLE.

Goto S, Merrill P, Wallentin L, Wojdyla DM, Hanna M, Avezum A, Easton JD, Harjola VP, Huber K, Lewis BS, Parkhomenko A, Zhu J, Granger CB, Lopes RD, Alexander JH.

Eur Heart J Cardiovasc Pharmacother. 2018 Apr 1;4(2):75-81. doi: 10.1093/ehjcvp/pvy002.

PMID: 29385429

 

Erratum to "CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma" [Eur Urol 2017;72:962-71].

Escudier B, Sharma P, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, Castellano D, Gurney H, Donskov F, Peltola K, Wagstaff J, Gauler TC, Ueda T, Zhao H, Waxman IM, Motzer RJ; CheckMate 025 investigators.

Eur Urol. 2018 Apr;73(4):e116-e118. doi: 10.1016/j.eururo.2017.12.016. Epub 2018 Jan 3. No abstract available.

PMID: 29306512

 

Major Histocompatibility Complex Class II and Programmed Death Ligand 1 Expression Predict Outcome After Programmed Death 1 Blockade in Classic Hodgkin Lymphoma.

Roemer MGM, Redd RA, Cader FZ, Pak CJ, Abdelrahman S, Ouyang J, Sasse S, Younes A, Fanale M, Santoro A, Zinzani PL, Timmerman J, Collins GP, Ramchandren R, Cohen JB, De Boer JP, Kuruvilla J, Savage KJ, Trneny M, Ansell S, Kato K, Farsaci B, Sumbul A, Armand P, Neuberg DS, Pinkus GS, Ligon AH, Rodig SJ, Shipp MA.

J Clin Oncol. 2018 Apr 1;36(10):942-950. doi: 10.1200/JCO.2017.77.3994. Epub 2018 Feb 2.

PMID: 29394125

 

Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction.

Zhang T, Zhang K, Ma L, Li Z, Wang J, Zhang Y, Lu C, Zhu M, Zhuang X.

J Pharm Sci. 2018 Apr;107(4):979-983. doi: 10.1016/j.xphs.2017.12.007. Epub 2017 Dec 14.

PMID: 29247736

 

Understanding the Factors That Control the Quality of Mini-Tablet Compression: Flow, Particle Size, and Tooling Dimension.

Zhao J, Yin D, Rowe J, Badawy S, Nikfar F, Pandey P.

J Pharm Sci. 2018 Apr;107(4):1204-1208. doi: 10.1016/j.xphs.2017.12.002. Epub 2017 Dec 9.

PMID: 29233726

 

Lack of ethnic differences of moxifloxacin and metabolite pharmacokinetics in East Asian men.

Kaneko M, Aoyama T, Ishida Y, Miyamoto A, Saito Y, Tohkin M, Kawai S, Matsumoto Y.

J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):199-214. doi: 10.1007/s10928-017-9556-7. Epub 2017 Nov 23.

PMID: 29170990

 

Economic burden of multiple myeloma among patients in successive lines of therapy in the United States.

MacEwan JP, Batt K, Yin W, Peneva D, Sison S, Vine S, Chen C.

Leuk Lymphoma. 2018 Apr;59(4):941-949. doi: 10.1080/10428194.2017.1361035. Epub 2017 Aug 13.

PMID: 28805105

 

Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media.

Xu J, Rehmann MS, Xu X, Huang C, Tian J, Qian NX, Li ZJ.

MAbs. 2018 Apr;10(3):488-499. doi: 10.1080/19420862.2018.1433978. Epub 2018 Feb 20.

PMID: 29388872

 

A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library.

Adler AS, Bedinger D, Adams MS, Asensio MA, Edgar RC, Leong R, Leong J, Mizrahi RA, Spindler MJ, Bandi SR, Huang H, Tawde P, Brams P, Johnson DS.

MAbs. 2018 Apr;10(3):431-443. doi: 10.1080/19420862.2018.1426422. Epub 2018 Feb 1.

PMID: 29376776

 

Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process.

Du C, Huang Y, Borwankar A, Tan Z, Cura A, Yee JC, Singh N, Ludwig R, Borys M, Ghose S, Mussa N, Li ZJ.

MAbs. 2018 Apr;10(3):500-510. doi: 10.1080/19420862.2018.1424609. Epub 2018 Jan 23.

PMID: 29336721

 

Monoclonal antibody higher order structure analysis by high throughput protein conformational array.

Song Y, Yu D, Mayani M, Mussa N, Li ZJ.

MAbs. 2018 Apr;10(3):397-405. doi: 10.1080/19420862.2017.1421880. Epub 2018 Jan 18.

PMID: 29313446

 

Combining intratumoral Treg depletion with androgen deprivation therapy (ADT): preclinical activity in the Myc-CaP model.

Shen YC, Ghasemzadeh A, Kochel CM, Nirschl TR, Francica BJ, Lopez-Bujanda ZA, Carrera Haro MA, Tam A, Anders RA, Selby MJ, Korman AJ, Drake CG.

Prostate Cancer Prostatic Dis. 2018 Apr;21(1):113-125. doi: 10.1038/s41391-017-0013-x. Epub 2017 Dec 4.

PMID: 29203894

 

Potential impurities in drug substances: Compound-specific toxicology limits for 20 synthetic reagents and by-products, and a class-specific toxicology limit for alkyl bromides.

Bercu JP, Galloway SM, Parris P, Teasdale A, Masuda-Herrera M, Dobo K, Heard P, Kenyon M, Nicolette J, Vock E, Ku W, Harvey J, White A, Glowienke S, Martin EA, Custer L, Jolly RA, Thybaud V.

Regul Toxicol Pharmacol. 2018 Apr;94:172-182. doi: 10.1016/j.yrtph.2018.02.001. Epub 2018 Feb 9.

PMID: 29408293

 

Association of anti-cyclic citrullinated protein antibodies, erosions, and rheumatoid factor with disease activity and work productivity: A patient registry study.

Alemao E, Guo Z, Frits ML, Iannaccone CK, Shadick NA, Weinblatt ME.

Semin Arthritis Rheum. 2018 Apr;47(5):630-638. doi: 10.1016/j.semarthrit.2017.10.009. Epub 2017 Oct 13.

PMID: 29241640

 

Discovery of Selective Cannabinoid CB2 Receptor Agonists by High-Throughput Screening.

Ogawa LM, Burford NT, Liao YH, Scott CE, Hine AM, Dowling C, Chin J, Power M, Hunnicutt EJ Jr., Emerick VL, Banks M, Zhang L, Gerritz SW, Alt A, Kendall DA.

SLAS Discov. 2018 Apr;23(4):375-383. doi: 10.1177/2472555217748403. Epub 2017 Dec 19.

PMID: 29257918

 

Spontaneous Findings in the Eyes of Cynomolgus Monkeys ( Macaca fascicularis) of Mauritian Origin.

Woicke J, Haile S, Mysore J, Peden WM, Lejeune T, Sanderson T, Brodie T.

Toxicol Pathol. 2018 Apr;46(3):273-282. doi: 10.1177/0192623318758619. Epub 2018 Feb 25.

PMID: 29478386

 

Conversion to seronegative status after abatacept treatment in patients with early and poor prognostic rheumatoid arthritis is associated with better radiographic outcomes and sustained remission: post hoc analysis of the AGREE study.

Jansen DTSL, Emery P, Smolen JS, Westhovens R, Le Bars M, Connolly SE, Ye J, Toes REM, Huizinga TWJ.

RMD Open. 2018 Mar 30;4(1):e000564. doi: 10.1136/rmdopen-2017-000564. eCollection 2018.

PMID: 29657830

 

Daclatasvir plus asunaprevir in treatment-naïve patients with hepatitis C virus genotype 1b infection.

Wei L, Wang FS, Zhang MX, Jia JD, Yakovlev AA, Xie W, Burnevich E, Niu JQ, Jung YJ, Jiang XJ, Xu M, Chen XY, Xie Q, Li J, Hou JL, Tang H, Dou XG, Gandhi Y, Hu WH, McPhee F, Noviello S, Treitel M, Mo L, Deng J.

World J Gastroenterol. 2018 Mar 28;24(12):1361-1372. doi: 10.3748/wjg.v24.i12.1361.

PMID: 29599611

 

Population Pharmacokinetic Analysis of Asunaprevir in Subjects with Hepatitis C Virus Infection.

Zhu L, Li H, Chan P, Eley T, Gandhi Y, Bifano M, Osawa M, Ueno T, Hughes E, AbuTarif M, Bertz R, Garimella T.

Infect Dis Ther. 2018 Mar 27. doi: 10.1007/s40121-018-0197-y. [Epub ahead of print]

PMID: 29589331

 

Nivolumab for Relapsed/Refractory Classic Hodgkin Lymphoma After Failure of Autologous Hematopoietic Cell Transplantation: Extended Follow-Up of the Multicohort Single-Arm Phase II CheckMate 205 Trial.

Armand P, Engert A, Younes A, Fanale M, Santoro A, Zinzani PL, Timmerman JM, Collins GP, Ramchandren R, Cohen JB, De Boer JP, Kuruvilla J, Savage KJ, Trneny M, Shipp MA, Kato K, Sumbul A, Farsaci B, Ansell SM.

J Clin Oncol. 2018 Mar 27:JCO2017760793. doi: 10.1200/JCO.2017.76.0793. [Epub ahead of print]

PMID: 29584546

 

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.

Nelp MT, Kates PA, Hunt JT, Newitt JA, Balog A, Maley D, Zhu X, Abell L, Allentoff A, Borzilleri R, Lewis HA, Lin Z, Seitz SP, Yan C, Groves JT.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3249-3254. doi: 10.1073/pnas.1719190115. Epub 2018 Mar 12.

PMID: 29531094

 

Regional Gastrointestinal Absorption of Apixaban in Healthy Subjects.

Byon W, Nepal S, Schuster AE, Shenker A, Frost CE.

J Clin Pharmacol. 2018 Mar 26. doi: 10.1002/jcph.1097. [Epub ahead of print]

PMID: 29578609

 

Posttransplant reduction in preexisting donor-specific antibody levels after belatacept- versus cyclosporine-based immunosuppression: Post hoc analyses of BENEFIT and BENEFIT-EXT.

Bray RA, Gebel HM, Townsend R, Roberts ME, Polinsky M, Yang L, Meier-Kriesche HU, Larsen CP.

Am J Transplant. 2018 Mar 24. doi: 10.1111/ajt.14738. [Epub ahead of print]

PMID: 29573335

 

Fluid flow modulates electrical activity in cardiac hERG potassium channels.

Roy S, Mathew MK.

J Biol Chem. 2018 Mar 23;293(12):4289-4303. doi: 10.1074/jbc.RA117.000432. Epub 2018 Jan 5.

PMID: 29305421

 

Five-Year Follow-Up of Nivolumab in Previously Treated Advanced Non-Small-Cell Lung Cancer: Results From the CA209-003 Study.

Gettinger S, Horn L, Jackman D, Spigel D, Antonia S, Hellmann M, Powderly J, Heist R, Sequist LV, Smith DC, Leming P, Geese WJ, Yoon D, Li A, Brahmer J.

J Clin Oncol. 2018 Mar 23:JCO2017770412. doi: 10.1200/JCO.2017.77.0412. [Epub ahead of print]

PMID: 29570421

 

Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.

Subbaiah MAM.

J Med Chem. 2018 Mar 22;61(6):2133-2165. doi: 10.1021/acs.jmedchem.6b01827. Epub 2017 Aug 25.

PMID: 28731336

 

Treatment Challenges in Venous Thromboembolism: An Appraisal of Rivaroxaban Studies.

Khorana AA, Weitz JI.

Thromb Haemost. 2018 Mar 22. doi: 10.1160/TH17-09-0681. [Epub ahead of print]

PMID: 29566417

 

 Retention and clinical response to abatacept in patients with rheumatoid arthritis: an Italian perspective.

Galeazzi M, Alten R, Chartier M, Elbez Y, Fusaro E, Le Bars M, Lorenz HM, Pagano Mariano G, Muratore M, Nüßlein HG, Patanè G.

Clin Exp Rheumatol. 2018 Mar 21. [Epub ahead of print] No abstract available.

PMID: 29600933

 

Determination of polymeric impurities in asunaprevir drug substance and product using size exclusion effect of reversed-phase columns.

Huang Z, Hu Y, Zha Y, Perrone R, Ruan J, Fish WP.

J Pharm Biomed Anal. 2018 Mar 20;151:200-208. doi: 10.1016/j.jpba.2018.01.018. Epub 2018 Jan 11.

PMID: 29353808

 

Treatment patterns for patients hospitalized with chronic obstructive pulmonary disease.

Amin AN, Bollu V, Stensland MD, Netzer L, Ganapathy V.

Am J Health Syst Pharm. 2018 Mar 15;75(6):359-366. doi: 10.2146/ajhp160979.

PMID: 29523532

 

Interim results of brentuximab vedotin in combination with nivolumab in patients with relapsed or refractory Hodgkin lymphoma.

Herrera AF, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Ansell SM, Moskowitz CH, Fenton K, Ogden CA, Taft D, Zhang Q, Kato K, Campbell M, Advani RH.

Blood. 2018 Mar 15;131(11):1183-1194. doi: 10.1182/blood-2017-10-811224. Epub 2017 Dec 11.

PMID: 29229594

 

Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids.

Hu Y, Carman JA, Holloway D, Kansal S, Fan L, Goldstine C, Lee D, Somerville JE, Latek R, Townsend R, Johnsen A, Connolly S, Bandyopadhyay S, Shadick N, Weinblatt ME, Furie R, Nadler SG.

Arthritis Rheumatol. 2018 Mar 13. doi: 10.1002/art.40476. [Epub ahead of print]

PMID: 29534336

 

Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles.

Chung S, Tian J, Tan Z, Chen J, Lee J, Borys M, Li ZJ.

Biotechnol Bioeng. 2018 Mar 13. doi: 10.1002/bit.26587. [Epub ahead of print] Review.

PMID: 29532901

 

Digoxin and Mortality in Patients With Atrial Fibrillation.

Lopes RD, Rordorf R, De Ferrari GM, Leonardi S, Thomas L, Wojdyla DM, Ridefelt P, Lawrence JH, De Caterina R, Vinereanu D, Hanna M, Flaker G, Al-Khatib SM, Hohnloser SH, Alexander JH, Granger CB, Wallentin L; ARISTOTLE Committees and Investigators.

J Am Coll Cardiol. 2018 Mar 13;71(10):1063-1074. doi: 10.1016/j.jacc.2017.12.060.

PMID: 29519345

 

Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer.

Overman MJ, Lonardi S, Wong KYM, Lenz HJ, Gelsomino F, Aglietta M, Morse MA, Van Cutsem E, McDermott R, Hill A, Sawyer MB, Hendlisz A, Neyns B, Svrcek M, Moss RA, Ledeine JM, Cao ZA, Kamble S, Kopetz S, André T.

J Clin Oncol. 2018 Mar 10;36(8):773-779. doi: 10.1200/JCO.2017.76.9901. Epub 2018 Jan 20.

PMID: 29355075

 

The cost-effectiveness of nivolumab monotherapy for the treatment of advanced melanoma patients in England.

Meng Y, Hertel N, Ellis J, Morais E, Johnson H, Philips Z, Roskell N, Walker A, Lee D.

Eur J Health Econ. 2018 Mar 9. doi: 10.1007/s10198-018-0964-4. [Epub ahead of print]

PMID: 29524005

 

Modeling the economic outcomes of immuno-oncology drugs: alternative model frameworks to capture clinical outcomes.

Gibson EJ, Begum N, Koblbauer I, Dranitsaris G, Liew D, McEwan P, Tahami Monfared AA, Yuan Y, Juarez-Garcia A, Tyas D, Lees M.

Clinicoecon Outcomes Res. 2018 Mar 8;10:139-154. doi: 10.2147/CEOR.S144208. eCollection 2018.

PMID: 29563820

 

Analytical comparability study of recombinant monoclonal antibody therapeutics.

Ambrogelly A, Gozo S, Katiyar A, Dellatore S, Kune Y, Bhat R, Sun J, Li N, Wang D, Nowak C, Neill A, Ponniah G, King C, Mason B, Beck A, Liu H.

MAbs. 2018 Mar 7:1-26. doi: 10.1080/19420862.2018.1438797. [Epub ahead of print]

PMID: 29513619

 

De novo donor-specific antibodies in belatacept-treated vs cyclosporine-treated kidney-transplant recipients: Post hoc analyses of the randomized phase III BENEFIT and BENEFIT-EXT studies.

Bray RA, Gebel HM, Townsend R, Roberts ME, Polinsky M, Yang L, Meier-Kriesche HU, Larsen CP.

Am J Transplant. 2018 Mar 6. doi: 10.1111/ajt.14721. [Epub ahead of print]

PMID: 29509295

 

Weight Loss and Timing of J Tube Removal in Biliopancreatic Diversion with Duodenal Switch Patients Who Report Physical or Sexual Abuse.

Hulme PA, Kupzyk KA, Anthone GJ, Capron KA, Nguyen T.

Obes Surg. 2018 Mar 6. doi: 10.1007/s11695-018-3166-3. [Epub ahead of print]

PMID: 29512037

 

Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.

Akuta N, Toyota J, Karino Y, Ikeda F, Ido A, Tanaka K, Takaguchi K, Naganuma A, Tomita E, Chayama K, Fujiyama S, Inada Y, Yoshiji H, Watanabe H, Ishikawa H, McPhee F, Noviello S, Kumada H.

J Gastroenterol. 2018 Mar 2. doi: 10.1007/s00535-018-1445-3. [Epub ahead of print]

PMID: 29500489

 

Strategy To Prepare 3-Bromo- and 3-Chloropyrazoles.

Fox RJ, Schmidt MA, Eastgate MD.

J Org Chem. 2018 Mar 2;83(5):2830-2839. doi: 10.1021/acs.joc.7b03282. Epub 2018 Feb 19.

PMID: 29429343

 

Organocatalyzed, Visible-Light Photoredox-Mediated, One-Pot Minisci Reaction Using Carboxylic Acids via N-(Acyloxy)phthalimides.

Sherwood TC, Li N, Yazdani AN, Dhar TGM.

J Org Chem. 2018 Mar 2;83(5):3000-3012. doi: 10.1021/acs.joc.8b00205. Epub 2018 Feb 14.

PMID: 29420898

 

Comparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines.

Gu X, Xiao Q, Ruan Q, Shu Y, Dongre A, Iyer R, Humphreys WG, Lai Y.

Acta Pharm Sin B. 2018 Mar;8(2):252-260. doi: 10.1016/j.apsb.2017.10.002. Epub 2017 Nov 4.

PMID: 29719786

 

Apixaban following acute coronary syndromes in patients with prior stroke: Insights from the APPRAISE-2 trial.

Sherwood MW, Lopes RD, Sun JL, Liaw D, Harrington RA, Wallentin L, Laskowitz DT, James SK, Goodman SG, Darius H, Lewis BS, Gibson CM, Pieper KS, Alexander JH.

Am Heart J. 2018 Mar;197:1-8. doi: 10.1016/j.ahj.2017.09.020. Epub 2017 Oct 24.

PMID: 29447769

 

Impact of Genetic Mutations and Health Plan Access to Therapies on Treatment Response and Drug Costs Related to Tyrosine Kinase Inhibitor Treatment Among Patients With Chronic Myelogenous Leukemia.

Jabbour E, Makenbaeva D, Lingohr-Smith M, Lin J.

Am J Clin Oncol. 2018 Mar;41(3):213-217. doi: 10.1097/COC.0000000000000252.

PMID: 26580245

 

Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial.

Rao MP, Vinereanu D, Wojdyla DM, Alexander JH, Atar D, Hylek EM, Hanna M, Wallentin L, Lopes RD, Gersh BJ, Granger CB; Apixaban for Reduction in Stroke Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators.

Am J Med. 2018 Mar;131(3):269-275.e2. doi: 10.1016/j.amjmed.2017.10.036. Epub 2017 Nov 6.

PMID: 29122636  

 

Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI).

Harikrishnan LS, Warrier J, Tebben AJ, Tonukunuru G, Madduri SR, Baligar V, Mannoori R, Seshadri B, Rahaman H, Arunachalam PN, Dikundwar AG, Fink BE, Fargnoli J, Fereshteh M, Fan Y, Lippy J, Ho CP, Wautlet B, Sheriff S, Ruzanov M, Borzilleri RM.

Bioorg Med Chem. 2018 Mar 1;26(5):1026-1034. doi: 10.1016/j.bmc.2018.01.014. Epub 2018 Jan 31.

PMID: 29422332

 

Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors.

Wu YJ, Guernon J, McClure A, Venables B, Rajamani R, Robbins KJ, Knox RJ, Matchett M, Pieschl RL, Herrington J, Bristow LJ, Meanwell NA, Olson R, Thompson LA, Dzierba C.

Bioorg Med Chem Lett. 2018 Mar 1;28(5):958-962. doi: 10.1016/j.bmcl.2018.01.035. Epub 2018 Feb 1.

PMID: 29439904

 

Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation.

Polasek TM, Tucker GT, Sorich MJ, Wiese MD, Mohan T, Rostami-Hodjegan A, Korprasertthaworn P, Perera V, Rowland A.

Br J Clin Pharmacol. 2018 Mar;84(3):462-476. doi: 10.1111/bcp.13480. Epub 2018 Jan 11.

PMID: 29194718

 

Impact of Warfarin Persistence on Health-Care Utilization and Costs Among Patients With Atrial Fibrillation Managed in Anticoagulation Clinics in the United States.

Deitelzweig SB, Evans M, Trocio J, Gupta K, Lingohr-Smith M, Menges B, Lin J.

Clin Appl Thromb Hemost. 2018 Mar;24(2):364-371. doi: 10.1177/1076029616685427. Epub 2017 Jan 31.

PMID: 28135822

 

The Clinical Pharmacology of Elotuzumab.

Passey C, Sheng J, Mora J, Tendolkar A, Robbins M, Dodge R, Roy A, Bello A, Gupta M.

Clin Pharmacokinet. 2018 Mar;57(3):297-313. doi: 10.1007/s40262-017-0585-6. Review.

PMID: 28779463

 

Effects of Mild to Severe Hepatic Impairment on the Pharmacokinetics of Sonidegib: A Multicenter, Open-Label, Parallel-Group Study.

Horsmans Y, Zhou J, Liudmila M, Golor G, Shibolet O, Quinlan M, Emotte C, Boss H, Castro H, Sellami D, Preston RA.

Clin Pharmacokinet. 2018 Mar;57(3):345-354. doi: 10.1007/s40262-017-0560-2.

PMID: 28577129

 

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use.

Nayak S, Sander O, Al-Huniti N, de Alwis D, Chain A, Chenel M, Sunkaraneni S, Agrawal S, Gupta N, Visser SAG.

Clin Pharmacol Ther. 2018 Mar;103(3):378-383. doi: 10.1002/cpt.978. Epub 2018 Jan 13.

PMID: 29330855

 

Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.

Nijsen MJMA, Wu F, Bansal L, Bradshaw-Pierce E, Chan JR, Liederer BM, Mettetal JT, Schroeder P, Schuck E, Tsai A, Xu C, Chimalakonda A, Le K, Penney M, Topp B, Yamada A, Spilker ME.

CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):135-146. doi: 10.1002/psp4.12282. Epub 2018 Feb 1. Review.

PMID: 29349875

 

Treatment and discharge patterns among patients hospitalized with non-valvular atrial fibrillation transitioning from the inpatient to outpatient setting.

Henk HJ, Cao F, Tuell K, Price K, Singh P, Mardekian J, Odell K, Patel C, Tan W, Sands GH, Singhal S, Trocio J, Vo L.

Curr Med Res Opin. 2018 Mar;34(3):539-546. doi: 10.1080/03007995.2017.1417029. Epub 2018 Jan 10.

PMID: 29235900

 

Comparison of major bleeding risk in patients with non-valvular atrial fibrillation receiving direct oral anticoagulants in the real-world setting: a network meta-analysis.

Deitelzweig S, Farmer C, Luo X, Li X, Vo L, Mardekian J, Fahrbach K, Ashaye A.

Curr Med Res Opin. 2018 Mar;34(3):487-498. doi: 10.1080/03007995.2017.1411793. Epub 2017 Dec 8.

PMID: 29188721

 

Outcomes associated with warfarin time in therapeutic range among US veterans with nonvalvular atrial fibrillation.

Liu S, Li X, Shi Q, Hamilton M, Friend K, Zhao Y, Horblyuk R, Hede S, Shi L.

Curr Med Res Opin. 2018 Mar;34(3):415-421. doi: 10.1080/03007995.2017.1384370. Epub 2017 Oct 3.

PMID: 28945114

 

Clinical Pharmacokinetics and the Impact of Genetic Polymorphism on a CYP2C19 Substrate, BMS-823778, in Healthy Subjects.

Gong J, Hansen L, Iacono L.

Drug Metab Dispos. 2018 Mar;46(3):316-325. doi: 10.1124/dmd.117.078824. Epub 2018 Jan 8.

PMID: 29311135

 

Effects of a Fixed-Dose Co-Formulation of Daclatasvir, Asunaprevir, and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects.

Garimella T, Tao X, Sims K, Chang YT, Rana J, Myers E, Wind-Rotolo M, Bhatnagar R, Eley T, LaCreta F, AbuTarif M.

Drugs R D. 2018 Mar;18(1):55-65. doi: 10.1007/s40268-017-0222-8.

PMID: 29255971

 

Economic impact of optimising antiretroviral treatment in human immunodeficiency virus-infected adults with suppressed viral load in Spain, by implementing the grade A-1 evidence recommendations of the 2015 GESIDA/National AIDS Plan.

Ribera E, Martínez-Sesmero JM, Sánchez-Rubio J, Rubio R, Pasquau J, Poveda JL, Pérez-Mitru A, Roldán C, Hernández-Novoa B.

Enferm Infecc Microbiol Clin. 2018 Mar;36(3):157-164. doi: 10.1016/j.eimc.2016.11.015. Epub 2017 Jan 20. English, Spanish.

PMID: 28109551

 

Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference.

Kotecha D, Breithardt G, Camm AJ, Lip GYH, Schotten U, Ahlsson A, Arnar D, Atar D, Auricchio A, Bax J, Benussi S, Blomstrom-Lundqvist C, Borggrefe M, Boriani G, Brandes A, Calkins H, Casadei B, Castellá M, Chua W, Crijns H, Dobrev D, Fabritz L, Feuring M, Freedman B, Gerth A, Goette A, Guasch E, Haase D, Hatem S, Haeusler KG, Heidbuchel H, Hendriks J, Hunter C, Kääb S, Kespohl S, Landmesser U, Lane DA, Lewalter T, Mont L, Nabauer M, Nielsen JC, Oeff M, Oldgren J, Oto A, Pison L, Potpara T, Ravens U, Richard-Lordereau I, Rienstra M, Savelieva I, Schnabel R, Sinner MF, Sommer P, Themistoclakis S, Van Gelder IC, Vardas PE, Verma A, Wakili R, Weber E, Werring D, Willems S, Ziegler A, Hindricks G, Kirchhof P.

Europace. 2018 Mar 1;20(3):395-407. doi: 10.1093/europace/eux318.

PMID: 29300976

 

Brief Report: Tenofovir-Associated Nephrotoxicity Among a US National Historical Cohort of HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals.

LaFleur J, Bress AP, Esker S, Knippenberg K, Crook J, Nyman H, Bedimo R, Tebas P, Rosenblatt L.

J Acquir Immune Defic Syndr. 2018 Mar 1;77(3):325-330. doi: 10.1097/QAI.0000000000001608.

PMID: 29210830

 

Viral Drug Resistance Through 48 Weeks, in a Phase 2b, Randomized, Controlled Trial of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir.

Lataillade M, Zhou N, Joshi SR, Lee S, Stock DA, Hanna GJ, Krystal M; AI438011 study team.

J Acquir Immune Defic Syndr. 2018 Mar 1;77(3):299-307. doi: 10.1097/QAI.0000000000001602.

PMID: 29206721

 

Real-world comparison of all-cause hospitalizations, hospitalizations due to stroke and major bleeding, and costs for non-valvular atrial fibrillation patients prescribed oral anticoagulants in a US health plan.

Amin A, Keshishian A, Vo L, Zhang Q, Dina O, Patel C, Odell K, Trocio J.

J Med Econ. 2018 Mar;21(3):244-253. doi: 10.1080/13696998.2017.1394866. Epub 2017 Nov 20.

PMID: 29047304

 

Comparative evaluation of treatment patterns and healthcare utilization of newly-diagnosed rheumatoid arthritis patients by anti-cyclic citrullinated peptide antibody status.

Lamerato L, Price K, Szymialis R, Eaddy M, Ogbonnaya A, Shih HC, Ahmad H.

J Med Econ. 2018 Mar;21(3):231-240. doi: 10.1080/13696998.2017.1391819. Epub 2017 Oct 24.

PMID: 29027497

 

Synthesis and Biologic Evaluation of a Novel 18F-Labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression.

Donnelly DJ, Smith RA, Morin P, Lipovšek D, Gokemeijer J, Cohen D, Lafont V, Tran T, Cole EL, Wright M, Kim J, Pena A, Kukral D, Dischino DD, Chow P, Gan J, Adelakun O, Wang XT, Cao K, Leung D, Bonacorsi SJ Jr., Hayes W.

J Nucl Med. 2018 Mar;59(3):529-535. doi: 10.2967/jnumed.117.199596. Epub 2017 Oct 12.

PMID: 29025984

 

Immune Modulation Therapy and Imaging: Workshop Report.

Shields AF, Jacobs PM, Sznol M, Graham MM, Germain RN, Lum LG, Jaffee EM, de Vries EGE, Nimmagadda S, Van den Abbeele AD, Leung DK, Wu AM, Sharon E, Shankar LK.

J Nucl Med. 2018 Mar;59(3):410-417. doi: 10.2967/jnumed.117.195610. Epub 2017 Aug 17.

PMID: 28818991

 

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis.

McQuade JL, Daniel CR, Hess KR, Mak C, Wang DY, Rai RR, Park JJ, Haydu LE, Spencer C, Wongchenko M, Lane S, Lee DY, Kaper M, McKean M, Beckermann KE, Rubinstein SM, Rooney I, Musib L, Budha N, Hsu J, Nowicki TS, Avila A, Haas T, Puligandla M, Lee S, Fang S, Wargo JA, Gershenwald JE, Lee JE, Hwu P, Chapman PB, Sosman JA, Schadendorf D, Grob JJ, Flaherty KT, Walker D, Yan Y, McKenna E, Legos JJ, Carlino MS, Ribas A, Kirkwood JM, Long GV, Johnson DB, Menzies AM, Davies MA.

Lancet Oncol. 2018 Mar;19(3):310-322. doi: 10.1016/S1470-2045(18)30078-0. Epub 2018 Feb 12.

PMID: 29449192

 

Neural correlates of audiovisual sensory integration.

Huang J, Reinders AATS, Wang Y, Xu T, Zeng YW, Li K, Handley R, Cheung EFC, Chan RCK, Dazzan P.

Neuropsychology. 2018 Mar;32(3):329-336. doi: 10.1037/neu0000393.

PMID: 29620404

 

Microbiological Control for Affinity Capture Chromatography Processing: An Industry Perspective.

Murphy M, Bell BL, Moshi J, Grassi R, Forng RY, Salaman A, Jordi PW, Zaidi S, Goodnight M, Paul M, Keller A, Carpenter B, Hearty U, Willison-Parry D.

PDA J Pharm Sci Technol. 2018 Mar-Apr;72(2):213-221. doi: 10.5731/pdajpst.2017.008045. Epub 2018 Feb 14.

PMID: 29444992

 

Systemic Loss of C-terminal Src Kinase Expression Elicits Spontaneous Suppurative Inflammation in Conditional Knockout Mice.

Berman-Booty LD, Eraslan R, Hanumegowda U, Cantor GH, Bounous DI, Janovitz EB, Jones BK, Buiakova O, Hayward M, Wee S.

Vet Pathol. 2018 Mar;55(2):331-340. doi: 10.1177/0300985817747330. Epub 2018 Jan 16.

PMID: 29338616

 

 Tenofovir-Associated Bone Adverse Outcomes among a US National Historical Cohort of HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals.

LaFleur J, Bress AP, Myers J, Rosenblatt L, Crook J, Knippenberg K, Bedimo R, Tebas P, Nyman H, Esker S.

Infect Dis Ther. 2018 Feb 28. doi: 10.1007/s40121-018-0194-1. [Epub ahead of print]

PMID: 29492905

 

Biphilic Organophosphorus-Catalyzed Intramolecular Csp2-H Amination: Evidence for a Nitrenoid in Catalytic Cadogan Cyclizations.

Nykaza TV, Ramirez A, Harrison TS, Luzung MR, Radosevich AT.

J Am Chem Soc. 2018 Feb 28;140(8):3103-3113. doi: 10.1021/jacs.7b13803. Epub 2018 Feb 12.

PMID: 29389114

 

Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers.

Hsieh DS, Luo L, Xu Y, Engstrom JD, Gao Q.

Pharm Res. 2018 Feb 28;35(4):79. doi: 10.1007/s11095-017-2305-1.

PMID: 29492686

 

Daclatasvir and sofosbuvir treatment of decompensated liver disease or post-liver transplant hepatitis C virus recurrence in patients with advanced liver disease/cirrhosis in a real-world cohort.

Kwo P, Fried MW, Reddy KR, Soldevila-Pico C, Khemichian S, Darling J, Zamor PJ, Napoli AA, Anduze-Faris B, Brown RS Jr..

Hepatol Commun. 2018 Feb 27;2(4):354-363. doi: 10.1002/hep4.1156. eCollection 2018 Apr.

PMID: 29619415

 

Reporting, Visualization, and Modeling of Immunogenicity Data to Assess Its Impact on Pharmacokinetics, Efficacy, and Safety of Monoclonal Antibodies.

Passey C, Suryawanshi S, Sanghavi K, Gupta M.

AAPS J. 2018 Feb 26;20(2):35. doi: 10.1208/s12248-018-0194-9.

PMID: 29484520

 

Subcutaneous Abatacept in Patients With Polyarticular-Course Juvenile Idiopathic Arthritis: Results From a Phase III Open-Label Study.

Brunner HI, Tzaribachev N, Vega-Cornejo G, Louw I, Berman A, Penadés IC, Antón J, Ávila-Zapata F, Cuttica R, Horneff G, Foeldvari I, Keltsev V, Kingsbury DJ, Viola DO, Joos R, Lauwerys B, Paz Gastañaga ME, Rama ME, Wouters C, Bohnsack J, Breedt J, Fischbach M, Lutz T, Minden K, Miraval T, Ally MM, Rubio-Pérez N, Solau Gervais E, van Zyl R, Li X, Nys M, Wong R, Banerjee S, Lovell DJ, Martini A, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO)the Pediatric Rheumatology Collaborative Study Group (PRCSG).

Arthritis Rheumatol. 2018 Feb 26. doi: 10.1002/art.40466. [Epub ahead of print]

PMID: 29481737

 

Nonclinical Safety Assessment of the γ-Secretase Inhibitor Avagacestat.

Simutis FJ, Sanderson TP, Pilcher GD, Graziano MJ.

Toxicol Sci. 2018 Feb 24. doi: 10.1093/toxsci/kfy048. [Epub ahead of print]

PMID: 29529279

 

Physiologically-based pharmacokinetic modelling of a CYP2C19 substrate, BMS-823778, utilizing pharmacogenetic data.

Gong J, Iacono L, Iyer RA, Humphreys WG, Zheng M.

Br J Clin Pharmacol. 2018 Feb 22. doi: 10.1111/bcp.13565. [Epub ahead of print]

PMID: 29469197

 

Evaluation of comparative effectiveness research: a practical tool.

Schaumberg DA, McDonald L, Shah S, Stokes M, Nordstrom BL, Ramagopalan SV.

J Comp Eff Res. 2018 Feb 21. doi: 10.2217/cer-2018-0007. [Epub ahead of print]

PMID: 29463115

 

Purity Determination by Capillary Electrophoresis Sodium Hexadecyl Sulfate (CE-SHS): A Novel Application For Therapeutic Protein Characterization.

Beckman J, Song Y, Gu Y, Voronov S, Chennamsetty N, Krystek S, Mussa N, Li ZJ.

Anal Chem. 2018 Feb 20;90(4):2542-2547. doi: 10.1021/acs.analchem.7b03831. Epub 2018 Feb 5.

PMID: 29357216

 

Streamlining Adverse Events Reporting in Oncology: An American Society of Clinical Oncology Research Statement.

Levit LA, Perez RP, Smith DC, Schilsky RL, Hayes DF, Vose JM.

J Clin Oncol. 2018 Feb 20;36(6):617-623. doi: 10.1200/JCO.2017.75.8193. Epub 2017 Dec 13. No abstract available.

PMID: 29236570

 

An Unexpected Degradation Pathway of a 1,2,4-Triazolo[4,3-a]pyridine Derivative: The Formation of 2 Cationic Pseudodimers of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor Drug Candidate in a Stressed Capsule Formulation.

Huang Y, Wang Q, Wu Y.

J Pharm Sci. 2018 Feb 17. pii: S0022-3549(18)30091-1. doi: 10.1016/j.xphs.2018.02.009. [Epub ahead of print]

PMID: 29458062

 

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma.

Miao D, Margolis CA, Gao W, Voss MH, Li W, Martini DJ, Norton C, Bossé D, Wankowicz SM, Cullen D, Horak C, Wind-Rotolo M, Tracy A, Giannakis M, Hodi FS, Drake CG, Ball MW, Allaf ME, Snyder A, Hellmann MD, Ho T, Motzer RJ, Signoretti S, Kaelin WG Jr., Choueiri TK, Van Allen EM.

Science. 2018 Feb 16;359(6377):801-806. doi: 10.1126/science.aan5951. Epub 2018 Jan 4.

PMID: 29301960

 

Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Williams DK, Markwalder JA, Balog AJ, Chen B, Chen L, Donnell J, Haque L, Hart AC, Mandal SK, Nation A, Shan W, Vite GD, Covello K, Hunt JT, Jure-Kunkel MN, Seitz SP.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):732-736. doi: 10.1016/j.bmcl.2018.01.010. Epub 2018 Jan 11.

PMID: 29398543

 

Safety and tolerability of dapagliflozin, saxagliptin and metformin in combination: Post-hoc analysis of concomitant add-on versus sequential add-on to metformin and of triple versus dual therapy with metformin.

Del Prato S, Rosenstock J, Garcia-Sanchez R, Iqbal N, Hansen L, Johnsson E, Chen H, Mathieu C.

Diabetes Obes Metab. 2018 Feb 15. doi: 10.1111/dom.13258. [Epub ahead of print]

PMID: 29446523

 

Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood.

Sorokin AV, Domenichiello AF, Dey AK, Yuan ZX, Goyal A, Rose SM, Playford MP, Ramsden CE, Mehta NN.

J Invest Dermatol. 2018 Feb 15. pii: S0022-202X(18)30121-0. doi: 10.1016/j.jid.2018.02.003. [Epub ahead of print]

PMID: 29454560

 

Adjuvant Therapy in Resected Melanoma.

Weber J, Qureshi A, Ascierto PA.

N Engl J Med. 2018 Feb 15;378(7):680. doi: 10.1056/NEJMc1716071. No abstract available.

PMID: 29446288

 

Opportunities and challenges for hybrid immunoaffinity LC-MS approach for quantitative analysis of protein biomarkers.

Zhao Y, Gu H, Zeng J.

Future Sci OA. 2018 Feb 14;4(3):FSO281. doi: 10.4155/fsoa-2017-0148. eCollection 2018 Mar. No abstract available.

PMID: 29568570  

 

Ni-Catalyzed Carbon-Carbon Bond-Forming Reductive Amination.

Heinz C, Lutz JP, Simmons EM, Miller MM, Ewing WR, Doyle AG.

J Am Chem Soc. 2018 Feb 14;140(6):2292-2300. doi: 10.1021/jacs.7b12212. Epub 2018 Feb 1.

PMID: 29341599

 

Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection.

Balsitis S, Gali V, Mason PJ, Chaniewski S, Levine SM, Wichroski MJ, Feulner M, Song Y, Granaldi K, Loy JK, Thompson CM, Lesniak JA, Brockus C, Kishnani N, Menne S, Cockett MI, Iyer R, Mason SW, Tenney DJ.

PLoS One. 2018 Feb 14;13(2):e0190058. doi: 10.1371/journal.pone.0190058. eCollection 2018.

PMID: 29444087

 

A real world example of coverage with evidence development in Australia - ipilimumab for the treatment of metastatic melanoma.

Kim H, Comey S, Hausler K, Cook G.

J Pharm Policy Pract. 2018 Feb 13;11:4. doi: 10.1186/s40545-018-0131-4. eCollection 2018.

PMID: 29456865

 

 Rethinking developmental toxicity testing: Evolution or revolution?

Scialli AR, Daston G, Chen C, Coder PS, Euling SY, Foreman J, Hoberman AM, Hui J, Knudsen T, Makris SL, Morford L, Piersma AH, Stanislaus D, Thompson KE.

Birth Defects Res. 2018 Feb 12. doi: 10.1002/bdr2.1212. [Epub ahead of print]

PMID: 29436169

 

Recommendations to Enhance Pediatric Cardiovascular Drug Development: Report of a Multi-Stakeholder Think Tank.

Torok RD, Li JS, Kannankeril PJ, Atz AM, Bishai R, Bolotin E, Breitenstein S, Chen C, Diacovo T, Feltes T, Furlong P, Hanna M, Graham EM, Hsu D, Ivy DD, Murphy D, Kammerman LA, Kearns G, Lawrence J, Lebeaut B, Li D, Male C, McCrindle B, Mugnier P, Newburger JW, Pearson GD, Peiris V, Percival L, Pina M, Portman R, Shaddy R, Stockbridge NL, Temple R, Hill KD.

J Am Heart Assoc. 2018 Feb 10;7(4). pii: e007283. doi: 10.1161/JAHA.117.007283. No abstract available.

PMID: 29440007

 

 Interaction Between the Sodium-Glucose-Linked Transporter 2 Inhibitor Dapagliflozin and the Loop Diuretic Bumetanide in Normal Human Subjects.

Wilcox CS, Shen W, Boulton DW, Leslie BR, Griffen SC.

J Am Heart Assoc. 2018 Feb 10;7(4). pii: e007046. doi: 10.1161/JAHA.117.007046.

PMID: 29440005

 

Cost-effectiveness of nivolumab in patients with advanced renal cell carcinoma treated in the United States.

McCrea C, Johal S, Yang S, Doan J.

Exp Hematol Oncol. 2018 Feb 9;7:4. doi: 10.1186/s40164-018-0095-8. eCollection 2018.

PMID: 29456880

 

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.

Miller EJ, Jecs E, Truax VM, Katzman BM, Tahirovic YA, Wilson RJ, Kuo KM, Kim MB, Nguyen HH, Saindane MT, Zhao H, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC.

J Med Chem. 2018 Feb 8;61(3):946-979. doi: 10.1021/acs.jmedchem.7b01420. Epub 2018 Jan 30.

PMID: 29350534

 

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.

Shi J, Gu Z, Jurica EA, Wu X, Haque LE, Williams KN, Hernandez AS, Hong Z, Gao Q, Dabros M, Davulcu AH, Mathur A, Rampulla RA, Gupta AK, Jayaram R, Apedo A, Moore DB, Liu H, Kunselman LK, Brady EJ, Wilkes JJ, Zinker BA, Cai H, Shu YZ, Sun Q, Dierks EA, Foster KA, Xu C, Wang T, Panemangalore R, Cvijic ME, Xie C, Cao GG, Zhou M, Krupinski J, Whaley JM, Robl JA, Ewing WR, Ellsworth BA.

J Med Chem. 2018 Feb 8;61(3):681-694. doi: 10.1021/acs.jmedchem.7b00982. Epub 2018 Jan 27.

PMID: 29316397

 

Submicron Protein Particle Characterization using Resistive Pulse Sensing and Conventional Light Scattering Based Approaches.

Barnett GV, Perhacs JM, Das TK, Kar SR.

Pharm Res. 2018 Feb 8;35(3):58. doi: 10.1007/s11095-017-2306-0.

PMID: 29423663

 

Cancer Immunotherapy: Factors Important for the Evaluation of Safety in Nonclinical Studies.

Herzyk DJ, Haggerty HG.

AAPS J. 2018 Feb 7;20(2):28. doi: 10.1208/s12248-017-0184-3.

PMID: 29417397

 

Protection of therapeutic antibodies from visible light induced degradation: use safe light in manufacturing and storage.

Du C, Barnett G, Borwankar A, Lewandowski A, Singh N, Ghose S, Borys M, Li ZJ.

Eur J Pharm Biopharm. 2018 Feb 7. pii: S0939-6411(17)31298-5. doi: 10.1016/j.ejpb.2018.02.007. [Epub ahead of print]

PMID: 29427628

 

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3.

Zhao Y, Chen F, Wu W, Sun M, Bilotta AJ, Yao S, Xiao Y, Huang X, Eaves-Pyles TD, Golovko G, Fofanov Y, D'Souza W, Zhao Q, Liu Z, Cong Y.

Mucosal Immunol. 2018 Feb 7. doi: 10.1038/mi.2017.118. [Epub ahead of print]

PMID: 29411774

 

Improving Mass Spectral Quality of Monoclonal Antibody Middle-Up LC-MS Analysis by Shifting the Protein Charge State Distribution.

Ding W, Qiu D, Bolgar MS, Miller SA.

Anal Chem. 2018 Feb 6;90(3):1560-1565. doi: 10.1021/acs.analchem.7b04423. Epub 2018 Jan 19.

PMID: 29294289

 

Capillary Isoelectric Focusing-Mass Spectrometry Method for the Separation and Online Characterization of Intact Monoclonal Antibody Charge Variants.

Dai J, Lamp J, Xia Q, Zhang Y.

Anal Chem. 2018 Feb 6;90(3):2246-2254. doi: 10.1021/acs.analchem.7b04608. Epub 2018 Jan 10.

PMID: 29272582

 

Long-term health-related quality-of-life and symptom response profiles with arformoterol in COPD: results from a 52-week trial.

Donohue JF, Bollu VK, Stull DE, Nelson LM, Williams VS, Stensland MD, Hanania NA.

Int J Chron Obstruct Pulmon Dis. 2018 Feb 5;13:499-508. doi: 10.2147/COPD.S141729. eCollection 2018.

PMID: 29440887

 

Assessment of swallowability and palatability of oral dosage forms in children: Report from an M-CERSI pediatric formulation workshop.

Ternik R, Liu F, Bartlett JA, Khong YM, Thiam Tan DC, Dixit T, Wang S, Galella EA, Gao Z, Klein S.

Int J Pharm. 2018 Feb 5;536(2):570-581. doi: 10.1016/j.ijpharm.2017.08.088. Epub 2017 Aug 24.

PMID: 28844897

 

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

Meanwell NA.

J Med Chem. 2018 Feb 5. doi: 10.1021/acs.jmedchem.7b01788. [Epub ahead of print]

PMID: 29400967

Initiation and continuation of oral anticoagulant prescriptions for stroke prevention in non-valvular atrial fibrillation: A cohort study in primary care in France.

Collings SL, Vannier-Moreau V, Johnson ME, Stynes G, Lefèvre C, Maguire A, Asmar J, Bizouard G, Duhot D, Mouquet F, Fauchier L.

Arch Cardiovasc Dis. 2018 Feb 2. pii: S1875-2136(17)30231-0. doi: 10.1016/j.acvd.2017.10.003. [Epub ahead of print]

PMID: 29398546

 

Two approaches for estimating the lower limit of quantitation (LLOQ) of microRNA levels assayed as exploratory biomarkers by RT-qPCR.

Wolfinger RD, Beedanagari S, Boitier E, Chen T, Couttet P, Ellinger-Ziegelbauer H, Guillemain G, Mariet C, Mouritzen P, O'Lone R, Pine PS, Sharapova T, Yan J, Yuen PS, Thompson KL.

BMC Biotechnol. 2018 Feb 2;18(1):6. doi: 10.1186/s12896-018-0415-4.

PMID:29391006

 

Association of Low Bone Mineral Density with Anti-Citrullinated Protein Antibody Positivity and Disease Activity in Established Rheumatoid Arthritis: Findings from a US Observational Cohort.

Ahmad HA, Alemao E, Guo Z, Iannaccone CK, Frits ML, Weinblatt M, Shadick NA.

Adv Ther. 2018 Feb;35(2):232-242. doi: 10.1007/s12325-017-0657-x. Epub 2018 Jan 25.

PMID: 29368271

 

On the article "Drugs targeting protease-activated receptor-4 improve the anti-thrombotic therapeutic window".

Wong PC, Yang J.

Ann Transl Med. 2018 Feb;6(3):71. doi: 10.21037/atm.2017.11.31. No abstract available.

PMID: 29611552

 

PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation.

Wilson SJ, Ismat FA, Wang Z, Cerra M, Narayan H, Raftis J, Gray TJ, Connell S, Garonzik S, Ma X, Yang J, Newby DE.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):448-456. doi: 10.1161/ATVBAHA.117.310104. Epub 2017 Dec 21.

PMID: 29269513

 

Emerging technologies for biotherapeutic bioanalysis from a high-throughput and multiplexing perspective: insights from an AAPS emerging technology action program committee.

Purushothama S, Dysinger M, Chen Y, Österlund K, Mora J, Chunyk AG, Peloquin R.

Bioanalysis. 2018 Feb;10(3):181-194. doi: 10.4155/bio-2017-0196. Epub 2018 Jan 18.

PMID: 29345151

 

Offline derivatization LC-MS/MS method for simultaneous estimation of vanillin and vanillic acid in guinea pig plasma.

Bhutani P, Murugesan S, Kumar A, Subramanian M, Prabhakar KR.

Bioanalysis. 2018 Feb;10(3):131-142. doi: 10.4155/bio-2017-0213. Epub 2018 Jan 15.

PMID: 29333866

 

One-step affinity capture and precipitation for improved purification of an industrial monoclonal antibody using Z-ELP functionalized nanocages.

Swartz AR, Xu X, Traylor SJ, Li ZJ, Chen W.

Biotechnol Bioeng. 2018 Feb;115(2):423-432. doi: 10.1002/bit.26467. Epub 2017 Oct 30.

PMID: 28986999

 

Incidence of type 2 diabetes mellitus and hyperlipidemia in patients prescribed dasatinib or nilotinib as first- or second-line

therapy for chronic myelogenous leukemia in the US.

Franklin M, Burns L, Perez S, Yerragolam D, Makenbaeva D.

Curr Med Res Opin. 2018 Feb;34(2):353-360. doi: 10.1080/03007995.2017.1399870. Epub 2017 Nov 30.

PMID: 29095654

 

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.

Shen H, Nelson DM, Oliveira RV, Zhang Y, Mcnaney CA, Gu X, Chen W, Su C, Reily MD, Shipkova PA, Gan J, Lai Y, Marathe P, Humphreys WG.

Drug Metab Dispos. 2018 Feb;46(2):178-188. doi: 10.1124/dmd.117.077586. Epub 2017 Nov 21.

PMID: 29162614

 

Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.

Billington S, Ray AS, Salphati L, Xiao G, Chu X, Humphreys WG, Liao M, Lee CA, Mathias A, Hop CECA, Rowbottom C, Evers R, Lai Y, Kelly EJ, Prasad B, Unadkat JD.

Drug Metab Dispos. 2018 Feb;46(2):189-196. doi: 10.1124/dmd.117.077289. Epub 2017 Nov 14.

PMID: 29138286

 

Dyslipidemia and Risk of Cardiovascular Events in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Therapy: Insights From the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) Trial.

Pol T, Held C, Westerbergh J, Lindbäck J, Alexander JH, Alings M, Erol C, Goto S, Halvorsen S, Huber K, Hanna M, Lopes RD, Ruzyllo W, Granger CB, Hijazi Z.

J Am Heart Assoc. 2018 Feb 1;7(3). pii: e007444. doi: 10.1161/JAHA.117.007444.

PMID: 29419390

 

Nivolumab Plus Ipilimumab in Patients With Advanced Melanoma: Updated Survival, Response, and Safety Data in a Phase I Dose-Escalation Study.

Callahan MK, Kluger H, Postow MA, Segal NH, Lesokhin A, Atkins MB, Kirkwood JM, Krishnan S, Bhore R, Horak C, Wolchok JD, Sznol M.

J Clin Oncol. 2018 Feb 1;36(4):391-398. doi: 10.1200/JCO.2017.72.2850. Epub 2017 Oct 17.

PMID: 29040030

 

Overall Survival in Patients With Advanced Melanoma Who Received Nivolumab Versus Investigator's Choice Chemotherapy in CheckMate 037: A Randomized, Controlled, Open-Label Phase III Trial.

Larkin J, Minor D, D'Angelo S, Neyns B, Smylie M, Miller WH Jr, Gutzmer R, Linette G, Chmielowski B, Lao CD, Lorigan P, Grossmann K, Hassel JC, Sznol M, Daud A, Sosman J, Khushalani N, Schadendorf D, Hoeller C, Walker D, Kong G, Horak C, Weber J.

J Clin Oncol. 2018 Feb 1;36(4):383-390. doi: 10.1200/JCO.2016.71.8023. Epub 2017 Jul 3.

PMID: 28671856

 

Confirming the timing of phase-based costing in oncology studies: a case example in advanced melanoma.

Atkins M, Coutinho AD, Nunna S, Gupte-Singh K, Eaddy M.

J Med Econ. 2018 Feb;21(2):212-217. doi: 10.1080/13696998.2017.1391818. Epub 2017 Oct 30.

PMID: 29022427

 

Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus Monkeys.

Gallezot JD, Nabulsi NB, Holden D, Lin SF, Labaree D, Ropchan J, Najafzadeh S, Donnelly DJ, Cao K, Bonacorsi S, Seiders J, Roppe J, Hayes W, Huang Y, Du S, Carson RE.

J Nucl Med. 2018 Feb;59(2):327-333. doi: 10.2967/jnumed.117.195073. Epub 2017 Sep 1.

PMID: 28864634

 

An Intercompany Perspective on Biopharmaceutical Drug Product Robustness Studies.

Morar-Mitrica S, Adams ML, Crotts G, Wurth C, Ihnat PM, Tabish T, Antochshuk V, DiLuzio W, Dix DB, Fernandez JE, Gupta K, Fleming MS, He B, Kranz JK, Liu D, Narasimhan C, Routhier E, Taylor KD, Truong N, Stokes ESE.

J Pharm Sci. 2018 Feb;107(2):529-542. doi: 10.1016/j.xphs.2017.10.017. Epub 2017 Oct 23.

PMID: 29074375

 

Understanding Protein-Interface Interactions of a Fusion Protein at Silicone Oil-Water Interface Probed by Sum Frequency Generation Vibrational Spectroscopy.

Li Y, Pan D, Nashine V, Deshmukh S, Vig B, Chen Z.

J Pharm Sci. 2018 Feb;107(2):682-689. doi: 10.1016/j.xphs.2017.09.029. Epub 2017 Oct 12.

PMID: 29031976

 

How to mathematically optimize drug regimens using optimal control.

Moore H.

J Pharmacokinet Pharmacodyn. 2018 Feb;45(1):127-137. doi: 10.1007/s10928-018-9568-y. Epub 2018 Feb 6.

PMID: 29411198

 

Mapping the central effects of (±)-ketamine and traxoprodil using pharmacological magnetic resonance imaging in awake rats.

Tang H, Kukral D, Li YW, Fronheiser M, Malone H, Pena A, Pieschl R, Sidik K, Tobon G, Chow PL, Bristow LJ, Hayes W, Luo F.

J Psychopharmacol. 2018 Feb;32(2):146-155. doi: 10.1177/0269881117746901. Epub 2018 Jan 30.

PMID: 29378483

 

Impact of Nivolumab versus Docetaxel on Health-Related Quality of Life and Symptoms in Patients with Advanced Squamous Non-Small Cell Lung Cancer: Results from the CheckMate 017 Study.

Reck M, Taylor F, Penrod JR, DeRosa M, Morrissey L, Dastani H, Orsini L, Gralla RJ.

J Thorac Oncol. 2018 Feb;13(2):194-204. doi: 10.1016/j.jtho.2017.10.029. Epub 2017 Nov 10.

PMID: 29129758

 

Challenges and new frontiers in analytical characterization of antibody-drug conjugates.

Wagh A, Song H, Zeng M, Tao L, Das TK.

MAbs. 2018 Feb/Mar;10(2):222-243. doi: 10.1080/19420862.2017.1412025. Epub 2018 Jan 5.

PMID: 29293399

 

Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors.

Livingston KE, Stanczyk MA, Burford NT, Alt A, Canals M, Traynor JR.

Mol Pharmacol. 2018 Feb;93(2):157-167. doi: 10.1124/mol.117.109561. Epub 2017 Dec 12.

PMID: 29233847

 

Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials.

Bloom S, Liu C, Kölmel DK, Qiao JX, Zhang Y, Poss MA, Ewing WR, MacMillan DWC.

Nat Chem. 2018 Feb;10(2):205-211. doi: 10.1038/nchem.2888. Epub 2017 Dec 4.

PMID: 29359756

 

Safety assessment of propylparaben in juvenile rats.

Sivaraman L, Pouliot L, Wang B, Brodie T, Graziano M, McNerney ME.

Regul Toxicol Pharmacol. 2018 Feb;92:370-381. doi: 10.1016/j.yrtph.2017.12.009. Epub 2017 Dec 15.

PMID: 29248488

 

'Cold shock' increases the frequency of homology directed repair gene editing in induced pluripotent stem cells.

Guo Q, Mintier G, Ma-Edmonds M, Storton D, Wang X, Xiao X, Kienzle B, Zhao D, Feder JN.

Sci Rep. 2018 Feb 1;8(1):2080. doi: 10.1038/s41598-018-20358-5.

PMID: 29391533

 

Leveraging the IncuCyte Technology for Higher-Throughput and Automated Chemotaxis Assays for Target Validation and Compound Characterization.

Chen J, Ribeiro B, Li H, Myer L, Chase P, Surti N, Lippy J, Zhang L, Cvijic ME.

SLAS Discov. 2018 Feb;23(2):122-131. doi: 10.1177/2472555217733437. Epub 2017 Sep 28.

PMID: 28957636

 

Requests for post-registration studies (PRS), patients follow-up in actual practice: Changes in the role of databases.

Berdaï D, Thomas-Delecourt F, Szwarcensztein K, d'Andon A, Collignon C, Comet D, Déal C, Dervaux B, Gaudin AF, Lamarque-Garnier V, Lechat P, Marque S, Maugendre P, Méchin H, Moore N, Nachbaur G, Robain M, Roussel C, Tanti A, Thiessard F.

Therapie. 2018 Feb;73(1):13-24. doi: 10.1016/j.therap.2017.12.008. Epub 2017 Dec 30.

PMID: 29530314

 

Demandes d’études post-inscription (EPI), suivi des patients en vie réelle : évolution de la place des bases de données.

Berdaï D, Thomas-Delecourt F, Szwarcensztein K; table ronde « recherche clinique et méthodologie » des Ateliers de Giens XXXIII, d'Andon A, Collignon C, Comet D, Déal C, Dervaux B, Gaudin AF, Lamarque-Garnier V, Lechat P, Marque S, Maugendre P, Méchin H, Moore N, Nachbaur G, Robain M, Roussel C, Tanti A, Thiessard F.

Therapie. 2018 Feb;73(1):1-12. doi: 10.1016/j.therap.2017.12.001. Epub 2017 Dec 12. French. No abstract available.

PMID: 29499906

 

Evaluation of Uracil, Sodium Ascorbate, and Rosiglitazone as Promoters of Urinary Bladder Transitional Cell Carcinomas in Male Sprague-Dawley Rats.

Tirmenstein M, Janovitz E, Dorr T, Song Y, Chen SJ, Granaldi K, Chadwick KD, Mangipudy R, Graziano M, Attalla B, Haile S, Czajkowski M, Foster JR, Bergholm AM, Billger M, Söderberg M.

Toxicol Pathol. 2018 Feb;46(2):147-157. doi: 10.1177/0192623318756004.

PMID: 29471778

 

Cost-Effectiveness Analysis of Abatacept Compared with Adalimumab on Background Methotrexate in Biologic-Naive Adult Patients with Rheumatoid Arthritis and Poor Prognosis.

Alemao E, Johal S, Al MJ, Rutten-van Mölken M.

Value Health. 2018 Feb;21(2):193-202. doi: 10.1016/j.jval.2017.05.020. Epub 2017 Jul 1.

PMID: 29477401

 

Stability behaviour of antiretroviral drugs and their combinations. 8: Characterization and in-silico toxicity prediction of degradation products of efavirenz.

Kurmi M, Sahu A, Singh DK, Singh IP, Singh S.

J Pharm Biomed Anal. 2018 Jan 30;148:170-181. doi: 10.1016/j.jpba.2017.09.029. Epub 2017 Oct 8.

PMID: 29055875

 

Selective C-H Halogenation with a Highly Fluorinated Manganese Porphyrin.

Li G, Dilger AK, Cheng PT, Ewing WR, Groves JT.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1251-1255. doi: 10.1002/anie.201710676. Epub 2017 Dec 28.

PMID: 29235203

 

Apixaban 5 and 2.5 mg twice-daily versus warfarin for stroke prevention in nonvalvular atrial fibrillation patients: Comparative effectiveness and safety evaluated using a propensity-score-matched approach.

Li X, Keshishian A, Hamilton M, Horblyuk R, Gupta K, Luo X, Mardekian J, Friend K, Nadkarni A, Pan X, Lip GYH, Deitelzweig S.

PLoS One. 2018 Jan 26;13(1):e0191722. doi: 10.1371/journal.pone.0191722. eCollection 2018.

PMID: 29373602

 

Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli.

Bohl TE, Shi K, Lee JK, Aihara H.

Nat Commun. 2018 Jan 25;9(1):377. doi: 10.1038/s41467-017-02712-9.

PMID: 29371662

 

Real world data in health technology assessments in kidney transplants in Germany: use of routinely collected data to address epidemiologic questions in kidney transplants in the AMNOG process in Germany.

Herrmann KH, Meier-Kriesche U, Neubauer AS.

Ger Med Sci. 2018 Jan 24;16:Doc01. doi: 10.3205/000263. eCollection 2018.

PMID: 29472834

 

Maternal Vitamin D Status and Infant Infection.

Moukarzel S, Ozias M, Kerling E, Christifano D, Wick J, Colombo J, Carlson S.

Nutrients. 2018 Jan 23;10(2). pii: E111. doi: 10.3390/nu10020111.

PMID: 29360733

 

Daclatasvir: A Review of Preclinical and Clinical Pharmacokinetics.

Gandhi Y, Eley T, Fura A, Li W, Bertz RJ, Garimella T.

Clin Pharmacokinet. 2018 Jan 20. doi: 10.1007/s40262-017-0624-3. [Epub ahead of print] Review.

PMID: 29353349

 

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.

Zheng B, D'Andrea SV, Sun LQ, Wang AX, Chen Y, Hrnciar P, Friborg J, Falk P, Hernandez D, Yu F, Sheaffer AK, Knipe JO, Mosure K, Rajamani R, Good AC, Kish K, Tredup J, Klei HE, Paruchuri M, Ng A, Gao Q, Rampulla RA, Mathur A, Meanwell NA, McPhee F, Scola PM.

ACS Med Chem Lett. 2018 Jan 19;9(2):143-148. doi: 10.1021/acsmedchemlett.7b00503. eCollection 2018 Feb 8.

PMID: 29456803

 

Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease.

Vinereanu D, Wang A, Mulder H, Lopes RD, Jansky P, Lewis BS, Gersh BJ, Avezum A, Hanna M, Held C, Wallentin L, Granger CB, Alexander JH.

Heart. 2018 Jan 19. pii: heartjnl-2017-312272. doi: 10.1136/heartjnl-2017-312272. [Epub ahead of print]

PMID: 29352007

 

Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors.

Crosby EJ, Wei J, Yang XY, Lei G, Wang T, Liu CX, Agarwal P, Korman AJ, Morse MA, Gouin K, Knott SRV, Lyerly HK, Hartman ZC.

Oncoimmunology. 2018 Jan 19;7(5):e1421891. doi: 10.1080/2162402X.2017.1421891. eCollection 2018.

PMID: 29721371

 

Protected Chloroethyl and Chloropropyl Amines as Conformationally Unrestricted Annulating Reagents.

Shi Q, Meehan MC, Galella M, Park H, Khandelwal P, Hynes J Jr., Dhar TGM, Marcoux D.

Org Lett. 2018 Jan 19;20(2):337-340. doi: 10.1021/acs.orglett.7b03548. Epub 2017 Dec 28.

PMID: 29283585  

 

Differential Susceptibility to T Cell-Induced Colitis in Mice: Role of the Intestinal Microbiota.

Reinoso Webb C, den Bakker H, Koboziev I, Jones-Hall Y, Rao Kottapalli K, Ostanin D, Furr KL, Mu Q, Luo XM, Grisham MB.

Inflamm Bowel Dis. 2018 Jan 18;24(2):361-379. doi: 10.1093/ibd/izx014.

PMID: 29361089

 

Adsorption of polypropylene oxide-polyethylene oxide type surfactants at surfaces of pharmaceutical relevant materials: effect of surface energetics and surfactant structures.

Li J, Rudraraju S, Zheng S, Jaiswal A.

Pharm Dev Technol. 2018 Jan 18:1-10. doi: 10.1080/10837450.2018.1425431. [Epub ahead of print]

PMID: 29304723

 

A survey of reasons for continuing warfarin therapy in the era of direct oral anticoagulants in Japanese patients with atrial fibrillation: the SELECT study.

Ikeda T, Yasaka M, Kida M, Imura M.

Patient Prefer Adherence. 2018 Jan 17;12:135-143. doi: 10.2147/PPA.S152584. eCollection 2018.

PMID: 29398909

 

Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.

Gong H, Weinstein DS, Lu Z, Duan JJ, Stachura S, Haque L, Karmakar A, Hemagiri H, Raut DK, Gupta AK, Khan J, Camac D, Sack JS, Pudzianowski A, Wu DR, Yarde M, Shen DR, Borowski V, Xie JH, Sun H, D'Arienzo C, Dabros M, Galella MA, Wang F, Weigelt CA, Zhao Q, Foster W, Somerville JE, Salter-Cid LM, Barrish JC, Carter PH, Dhar TGM.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):85-93. doi: 10.1016/j.bmcl.2017.12.006. Epub 2017 Dec 5.

PMID: 29233651

 

Recent encounters with atropisomerism in drug discovery.

Glunz PW.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):53-60. doi: 10.1016/j.bmcl.2017.11.050. Epub 2017 Dec 6. Review.

PMID: 29223590

 

Interactions between a poorly soluble cationic drug and sodium dodecyl sulfate in dissolution medium and their impact on in vitro dissolution behavior.

Huang Z, Parikh S, Fish WP.

Int J Pharm. 2018 Jan 15;535(1-2):350-359. doi: 10.1016/j.ijpharm.2017.10.063. Epub 2017 Nov 20.

PMID: 29104060

 

Challenges and Opportunities With Oncology Drug Development in China.

Bajaj G, Gupta M, Wang HH, Barrett JS, Tan M, Rupalla K, Bertz R, Sheng J.

Clin Pharmacol Ther. 2018 Jan 12. doi: 10.1002/cpt.1017. [Epub ahead of print] Review.

PMID: 29328503

 

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir.

Meanwell NA, Krystal MR, Nowicka-Sans B, Langley DR, Conlon DA, Eastgate MD, Grasela DM, Timmins P, Wang T, Kadow JF.

J Med Chem. 2018 Jan 11;61(1):62-80. doi: 10.1021/acs.jmedchem.7b01337. Epub 2017 Dec 22.

PMID: 29271653

 

Evaluation of a developmental hierarchy for breast cancer cells to assess risk-based patient selection for targeted treatment.

Bliss SA, Paul S, Pobiarzyn PW, Ayer S, Sinha G, Pant S, Hilton H, Sharma N, Cunha MF, Engelberth DJ, Greco SJ, Bryan M, Kucia MJ, Kakar SS, Ratajczak MZ, Rameshwar P.

Sci Rep. 2018 Jan 10;8(1):367. doi: 10.1038/s41598-017-18834-5.

PMID: 29321622

 

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective.

Shebley M, Sandhu P, Emami Riedmaier A, Jamei M, Narayanan R, Patel A, Peters SA, Reddy VP, Zheng M, de Zwart L, Beneton M, Bouzom F, Chen J, Chen Y, Cleary Y, Collins C, Dickinson GL, Djebli N, Einolf HJ, Gardner I, Huth F, Kazmi F, Khalil F, Lin J, Odinecs A, Patel C, Rong H, Schuck E, Sharma P, Wu SP, Xu Y, Yamazaki S, Yoshida K, Rowland M.

Clin Pharmacol Ther. 2018 Jan 9. doi: 10.1002/cpt.1013. [Epub ahead of print] Review.

PMID: 29315504

 

Applications of 2, 2, 2 trifluoroethanol as a versatile co-solvent in supercritical fluid chromatography for purification of unstable boronate esters, enhancing throughput, reducing epimerization, and for additive free purifications.

Asokan K, Shaikh KM, Tele SS, Chauthe SK, Ansar S, Vetrichelvan M, Nimje R, Gupta A, Gupta AK, Sarabu R, Wu DR, Mathur A, Bajpai L.

J Chromatogr A. 2018 Jan 5;1531:122-130. doi: 10.1016/j.chroma.2017.11.031. Epub 2017 Nov 20.

PMID: 29174572

 

Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs: a descriptive analysis of data from interventional trials and the real-world setting.

Alten R, Burkhardt H, Feist E, Krüger K, Rech J, Rubbert-Roth A, Voll RE, Elbez Y, Rauch C.

Arthritis Res Ther. 2018 Jan 2;20(1):1. doi: 10.1186/s13075-017-1488-5.

PMID: 29329602

 

Commentary: Why Pharmaceutical Scientists in Early Drug Discovery Are Critical for Influencing the Design and Selection of Optimal Drug Candidates.

Landis MS, Bhattachar S, Yazdanian M, Morrison J.

AAPS PharmSciTech. 2018 Jan;19(1):1-10. doi: 10.1208/s12249-017-0849-3. Epub 2017 Jul 28.

PMID: 28755053

 

Characterization of a Liquid Crystal System for Sustained Release of a Peptide BMS-686117.

Xu Y, Li V, Li J, Pan D, Langenbucher G, Mathias N.

AAPS PharmSciTech. 2018 Jan;19(1):348-357. doi: 10.1208/s12249-017-0835-9. Epub 2017 Jul 24.

PMID: 8741139

 

Cost-Effectiveness of Cetuximab as First-line Treatment for Metastatic Colorectal Cancer in the United States.

Shankaran V, Ortendahl JD, Purdum AG, Bolinder B, Anene AM, Sun GH, Bentley TGK.

Am J Clin Oncol. 2018 Jan;41(1):65-72. doi: 10.1097/COC.0000000000000231.

PMID: 26398184

 

Pooled analysis of HCV genotype 1 resistance-associated substitutions in NS5A, NS3 and NS5B pre-and post-treatment with 12 weeks of daclatasvir, asunaprevir and beclabuvir.

McPhee F, Hernandez D, Zhou N, Ueland J, Yu F, Vellucci V, Huang X, Wang X, Ishikawa H, Karino Y, Kumada H.

Antivir Ther. 2018;23(1):53-66. doi: 10.3851/IMP3177.

PMID: 28594332

 

Development of a Diagnostic Programmed Cell Death 1-Ligand 1 Immunohistochemistry Assay for Nivolumab Therapy in Melanoma.

Phillips T, Millett MM, Zhang X, Jansson M, Cleveland R, Simmons P, Cherryholmes G, Carnahan J, William J, Spaulding B, Satnick IR, Inzunza HD, Taylor C, Cogswell J, Novotny J, Oroudjev E, Winther H.

Appl Immunohistochem Mol Morphol. 2018 Jan;26(1):6-12. doi: 10.1097/PAI.0000000000000605.

PMID: 29189265

 

Highly selective and sensitive measurement of active forms of FGF21 using novel immunocapture enrichment with LC-MS/MS.

Zhao Y, Liu G, Kwok S, Jones BR, Liu J, Marchisin D, Joyce PE, Peterson J, Shen JX.

Bioanalysis. 2018 Jan;10(1):23-33. doi: 10.4155/bio-2017-0208. Epub 2017 Dec 14.

PMID: 29239666

 

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.

Bowsher M, Hiebert S, Li R, Wang AX, Friborg J, Yu F, Hernandez D, Wang YK, Klei H, Rajamani R, Mosure K, Knipe JO, Meanwell NA, McPhee F, Scola PM.

Bioorg Med Chem Lett. 2018 Jan 1;28(1):43-48. doi: 10.1016/j.bmcl.2017.11.005. Epub 2017 Nov 3.

PMID: 29162454

 

Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11β-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778.

Cheng Y, Wang L, Iacono L, Zhang D, Chen W, Gong J, Humphreys WG, Gan J.

Br J Clin Pharmacol. 2018 Jan;84(1):130-141. doi: 10.1111/bcp.13421. Epub 2017 Oct 4.

PMID: 28850715

 

CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8+ T Cell-Relevant Genes.

Aznar MA, Labiano S, Diaz-Lagares A, Molina C, Garasa S, Azpilikueta A, Etxeberria I, Sanchez-Paulete AR, Korman AJ, Esteller M, Sandoval J, Melero I.

Cancer Immunol Res. 2018 Jan;6(1):69-78. doi: 10.1158/2326-6066.CIR-17-0159. Epub 2017 Nov 13.

PMID: 29133290

 

Conditioned media from the renal cell carcinoma cell line 786.O drives human blood monocytes to a monocytic myeloid-derived suppressor cell phenotype.

Okada SL, Simmons RM, Franke-Welch S, Nguyen TH, Korman AJ, Dillon SR, Gilbertson DG.

Cell Immunol. 2018 Jan;323:49-58. doi: 10.1016/j.cellimm.2017.10.014. Epub 2017 Oct 31.

PMID: 29103587

 

Preface.

Sinz M.

Curr Drug Metab. 2018;19(1):2. doi: 10.2174/138920021901180328155936. No abstract available.

PMID: 29618306

 

Association Between Inflammatory Markers and Progression to Kidney Dysfunction: Examining Different Assessment Windows in Patients With Type 1 Diabetes.

Baker NL, Hunt KJ, Stevens DR, Jarai G, Rosen GD, Klein RL, Virella G, Lopes-Virella MF; DCCT/EDIC Research Group.

Diabetes Care. 2018 Jan;41(1):128-135. doi: 10.2337/dc17-0867. Epub 2017 Nov 8.

PMID: 29118060

 

Efficacy and tolerability of the new autoinjected suspension of exenatide once weekly versus exenatide twice daily in patients with type 2 diabetes.

Wysham CH, Rosenstock J, Vetter ML, Dong F, Öhman P, Iqbal N.

Diabetes Obes Metab. 2018 Jan;20(1):165-172. doi: 10.1111/dom.13056. Epub 2017 Aug 22.

PMID: 28685973

 

CHEMGENIE: integration of chemogenomics data for applications in chemical biology.

Kutchukian PS, Chang C, Fox SJ, Cook E, Barnard R, Tellers D, Wang H, Pertusi D, Glick M, Sheridan RP, Wallace IM, Wassermann AM.

Drug Discov Today. 2018 Jan;23(1):151-160. doi: 10.1016/j.drudis.2017.09.004. Epub 2017 Sep 14. Review.

PMID: 28917822

 

Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry.

Huang RY, Iacob RE, Sankaranarayanan S, Yang L, Ahlijanian M, Tao L, Tymiak AA, Chen G.

J Am Soc Mass Spectrom. 2018 Jan;29(1):174-182. doi: 10.1007/s13361-017-1815-8. Epub 2017 Oct 2.

PMID:  28971440

 

The Economic Burden of ACPA-Positive Status Among Patients with Rheumatoid Arthritis.

Shafrin J, Tebeka MG, Price K, Patel C, Michaud K.

J Manag Care Spec Pharm. 2018 Jan;24(1):4-11. doi: 10.18553/jmcp.2017.17129. Epub 2017 Jul 17.

PMID: 29290168

 

Relapse-Free Survival as a Surrogate for Overall Survival in the Evaluation of Stage II-III Melanoma Adjuvant Therapy.

Suciu S, Eggermont AMM, Lorigan P, Kirkwood JM, Markovic SN, Garbe C, Cameron D, Kotapati S, Chen TT, Wheatley K, Ives N, de Schaetzen G, Efendi A, Buyse M.

J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx133. Review.

PMID: 28922786

 

Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance.

Chen H, Pui Y, Liu C, Chen Z, Su CC, Hageman M, Hussain M, Haskell R, Stefanski K, Foster K, Gudmundsson O, Qian F.

J Pharm Sci. 2018 Jan;107(1):317-326. doi: 10.1016/j.xphs.2017.10.028. Epub 2017 Oct 26.

PMID: 29107047

 

Industry's View on Using Quality Control, Biorelevant, and Clinically Relevant Dissolution Tests for Pharmaceutical Development, Registration, and Commercialization.

Grady H, Elder D, Webster GK, Mao Y, Lin Y, Flanagan T, Mann J, Blanchard A, Cohen MJ, Lin J, Kesisoglou F, Hermans A, Abend A, Zhang L, Curran D.

J Pharm Sci. 2018 Jan;107(1):34-41. doi: 10.1016/j.xphs.2017.10.019. Epub 2017 Oct 24. Review.

PMID: 29074376

 

Effect of Anticitrullinated Protein Antibody Status on Response to Abatacept or Antitumor Necrosis Factor-α Therapy in Patients with Rheumatoid Arthritis: A US National Observational Study.

Harrold LR, Litman HJ, Connolly SE, Kelly S, Hua W, Alemao E, Rosenblatt L, Rebello S, Kremer JM.

J Rheumatol. 2018 Jan;45(1):32-39. doi: 10.3899/jrheum.170007. Epub 2017 Nov 1.

PMID:29093151  

 

Kinesiophobia and physical therapy-related pain in musculoskeletal pain: A national multicenter cohort study on patients and their general physicians.

Perrot S, Trouvin AP, Rondeau V, Chartier I, Arnaud R, Milon JY, Pouchain D.

Joint Bone Spine. 2018 Jan;85(1):101-107. doi: 10.1016/j.jbspin.2016.12.014. Epub 2017 Jan 3.

PMID: 28062380

 

Large-scale surveillance study of the safety and effectiveness of entecavir in Korean patients with chronic hepatitis B.

Kim CW, Kim CS, Kim HY, Lee CD, Yu K, Llamoso C, Lee HJ.

Korean J Intern Med. 2018 Jan;33(1):91-101. doi: 10.3904/kjim.2016.111. Epub 2017 Dec 13.

PMID: 29228519

 

Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction.

Huang RY, Krystek SR Jr., Felix N, Graziano RF, Srinivasan M, Pashine A, Chen G.

MAbs. 2018 Jan;10(1):95-103. doi: 10.1080/19420862.2017.1393595. Epub 2017 Nov 14.

PMID: 29135326

 

Epitope Mapping Using Yeast Display and Next Generation Sequencing.

Van Blarcom T, Rossi A, Foletti D, Sundar P, Pitts S, Melton Z, Telman D, Zhao L, Cheung WL, Berka J, Zhai W, Strop P, Pons J, Rajpal A, Chaparro-Riggers J.

Methods Mol Biol. 2018;1785:89-118. doi: 10.1007/978-1-4939-7841-0_7.

PMID: 29714014

 

High-Content Reporter Assays.

Cook E, Hermes J, Li J, Tudor M.

Methods Mol Biol. 2018;1755:179-195. doi: 10.1007/978-1-4939-7724-6_13.

PMID: 29671271

 

Proteomic Profiling of Hsp90 Inhibitors.

Voruganti S, Kline JT, Balch MJ, Rogers J, Matts RL, Hartson SD.

Methods Mol Biol. 2018;1709:139-162. doi: 10.1007/978-1-4939-7477-1_11.

PMID: 29177657

 

Utilization of Multidimensional Data in the Analysis of Ultra-High-Throughput High Content Phenotypic Screens.

Wardwell-Swanson J, Hu Y.

Methods Mol Biol. 2018;1683:267-290. doi: 10.1007/978-1-4939-7357-6_16.

PMID: 29082498

 

Challenges and Opportunities in Enabling High-Throughput, Miniaturized High Content Screening.

Nickischer D, Elkin L, Cloutier N, O'Connell J, Banks M, Weston A.

Methods Mol Biol. 2018;1683:165-191. doi: 10.1007/978-1-4939-7357-6_11.

PMID: 29082493

 

Predictors of Response and Survival in Locally Advanced Adenocarcinoma of the Pancreas Following Neoadjuvant GTX with or Without Radiation Therapy.

Sherman WH, Hecht E, Leung D, Chu K.

Oncologist. 2018 Jan;23(1):4-e10. doi: 10.1634/theoncologist.2017-0208. Epub 2017 Dec 6.

PMID: 29212734

 

Antibody drug conjugates for treatment of breast cancer: Novel targets and diverse approaches in ADC design.

Trail PA, Dubowchik GM, Lowinger TB.

Pharmacol Ther. 2018 Jan;181:126-142. doi: 10.1016/j.pharmthera.2017.07.013. Epub 2017 Jul 27. Review.

PMID: 28757155

 

Medical Writing Competency Model - Section 2: Knowledge, Skills, Abilities, and Behaviors.

Clemow DB, Wagner B, Marshallsay C, Benau D, L'Heureux D, Brown DH, Dasgupta DG, Girten E, Hubbard F, Gawrylewski HM, Ebina H, Stoltenborg J, York JP, Green K, Wood LF, Toth L, Mihm M, Katz NR, Vasconcelos NM, Sakiyama N, Whitsell R, Gopalakrishnan S, Bairnsfather S, Wanderer T, Schindler TM, Mikyas Y, Aoyama Y.

Ther Innov Regul Sci. 2018 Jan;52(1):78-88. doi: 10.1177/2168479017723680. Epub 2017 Aug 30.

PMID: 29714614

 

Medical Writing Competency Model - Section 1: Functions, Tasks, and Activities.

Clemow DB, Wagner B, Marshallsay C, Benau D, L'Heureux D, Brown DH, Dasgupta DG, Girten E, Hubbard F, Gawrylewski HM, Ebina H, Stoltenborg J, York JP, Green K, Wood LF, Toth L, Mihm M, Katz NR, Vasconcelos NM, Sakiyama N, Whitsell R, Gopalakrishnan S, Bairnsfather S, Wanderer T, Schindler TM, Mikyas Y, Aoyama Y.

Ther Innov Regul Sci. 2018 Jan;52(1):70-77. doi: 10.1177/2168479017721585. Epub 2017 Sep 1.

PMID: 29714611

 

The Near-Term Viability and Benefits of eLabels for Patients, Clinical Sites, and Sponsors.

Smith-Gick J, Barnes N, Barone R, Bedford J, James JR, Reisner SF, Stephenson M.

Ther Innov Regul Sci. 2018 Jan 1:2168479018765463. doi: 10.1177/2168479018765463. [Epub ahead of print]

PMID: 29714582

2017 Publications

Impact of CO2-solvent separators on the degradation of benzyl-2,3-dihydroxypiperidine-1-carboxylate during preparative supercritical fluid chromatographic (SFC) purification.

Asokan K, Naidu H, Madam R, Shaikh KM, Reddy M, Kumar H, Shirude PS, Rajendran M, Sarabu R, Wu DR, Bajpai L, Zhang Y.

J Chromatogr A. 2017 Dec 29;1530:176-184. doi: 10.1016/j.chroma.2017.11.025. Epub 2017 Nov 14.

PMID: 29162234

Real-world predictors of 12-month intravenous abatacept retention in patients with rheumatoid arthritis in the ACTION observational study.

Alten R, Mariette X, Lorenz HM, Galeazzi M, Cantagrel A, Nüßlein HG, Chartier M, Elbez Y, Rauch C, Le Bars M.

RMD Open. 2017 Dec 29;3(2):e000538. doi: 10.1136/rmdopen-2017-000538. eCollection 2017.

PMID: 29435360

Nivolumab and Ipilimumab in Advanced Melanoma.

Wolchok JD, Rollin L, Larkin J.

N Engl J Med. 2017 Dec 21;377(25):2503-2504. doi: 10.1056/NEJMc1714339. No abstract available.

PMID: 29262279

Identification of 5-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-Carboxamides as Novel and Selective Monoamine Oxidase B Inhibitors Used to Improve Memory and Cognition.

Kaplan AP, Keenan T, Scott R, Zhou X, Bourchouladze R, McRiner AJ, Wilson ME, Romashko D, Miller R, Bletsch M, Anderson G, Stanley J, Zhang A, Lee D, Nikpur J.

ACS Chem Neurosci. 2017 Dec 20;8(12):2746-2758. doi: 10.1021/acschemneuro.7b00282. Epub 2017 Sep 20.

PMID: 28857544

 

Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains.

Jecs E, Miller EJ, Wilson RJ, Nguyen HH, Tahirovic YA, Katzman BM, Truax VM, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC.

ACS Med Chem Lett. 2017 Dec 20;9(2):89-93. doi: 10.1021/acsmedchemlett.7b00406. eCollection 2018 Feb 8.

PMID: 29456793

 

Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.

Weed MR, Polino J, Signor L, Bookbinder M, Keavy D, Benitex Y, Morgan DG, King D, Macor JE, Zaczek R, Olson R, Bristow LJ.

PLoS One. 2017 Dec 19;12(12):e0187609. doi: 10.1371/journal.pone.0187609. eCollection 2017.

PMID: 29261656

Assessment and modelling of antibacterial combination regimens.

Rao GG, Li J, Garonzik SM, Nation RL, Forrest A.

Clin Microbiol Infect. 2017 Dec 18. pii: S1198-743X(17)30677-8. doi: 10.1016/j.cmi.2017.12.004. [Epub ahead of print] Review.

PMID: 29269090

 

Drug-target interactions that involve the replacement or displacement of magnesium ions.

Meanwell NA.

Bioorg Med Chem Lett. 2017 Dec 15;27(24):5355-5372. doi: 10.1016/j.bmcl.2017.11.002. Epub 2017 Nov 10. Review.

PMID: 29132752

Cost-effectiveness of early treatment of ACPA-positive rheumatoid arthritis patients with abatacept.

Neubauer AS, Minartz C, Herrmann KH, Baerwald CGO.

Clin Exp Rheumatol. 2017 Dec 15. [Epub ahead of print]

PMID: 29303709

Gaining Mechanistic Insight Into Coproporphyrin I as Endogenous Biomarker for OATP1B-Mediated Drug-Drug Interactions Using Population Pharmacokinetic Modeling and Simulation.

Barnett S, Ogungbenro K, Ménochet K, Shen H, Lai Y, Humphreys WG, Galetin A.

Clin Pharmacol Ther. 2017 Dec 15. doi: 10.1002/cpt.983. [Epub ahead of print]

PMID: 29243231

 

NaV channel variants in patients with painful and nonpainful peripheral neuropathy.

Wadhawan S, Pant S, Golhar R, Kirov S, Thompson J, Jacobsen L, Qureshi I, Ajroud-Driss S, Freeman R, Simpson DM, Smith AG, Hoke A, Bristow LJ.

Neurol Genet. 2017 Dec 15;3(6):e207. doi: 10.1212/NXG.0000000000000207. eCollection 2017 Dec.

PMID: 29264398

Patient satisfaction after switching from warfarin to apixaban in patients with nonvalvular atrial fibrillation: AGAIN study.

Koretsune Y, Ikeda T, Kozuma K, Hirano T, Yasaka M, Kida M, Chachin M, Imura M.

Patient Prefer Adherence. 2017 Dec 15;11:1987-1996. doi: 10.2147/PPA.S152579. eCollection 2017.

PMID: 29290682

Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).

Pinto DJP, Orwat MJ, Smith LM 2nd, Quan ML, Lam PYS, Rossi KA, Apedo A, Bozarth JM, Wu Y, Zheng JJ, Xin B, Toussaint N, Stetsko P, Gudmundsson O, Maxwell B, Crain EJ, Wong PC, Lou Z, Harper TW, Chacko SA, Myers JE Jr, Sheriff S, Zhang H, Hou X, Mathur A, Seiffert DA, Wexler RR, Luettgen JM, Ewing WR.

J Med Chem. 2017 Dec 14;60(23):9703-9723. doi: 10.1021/acs.jmedchem.7b01171. Epub 2017 Nov 17.

PMID: 29077405

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.

Zhuo X, Wang YZ, Yeung KS, Zhu J, Huang XS, Parcella KE, Eastman KJ, Kadow JF, Meanwell NA, Shu YZ, Johnson BM.

Xenobiotica. 2017 Dec 12:1-12. doi: 10.1080/00498254.2017.1409915. [Epub ahead of print]

PMID: 29182424

Nivolumab Versus Docetaxel in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer: Two-Year Outcomes From Two Randomized, Open-Label, Phase III Trials (CheckMate 017 and CheckMate 057).

Horn L, Spigel DR, Vokes EE, Holgado E, Ready N, Steins M, Poddubskaya E, Borghaei H, Felip E, Paz-Ares L, Pluzanski A, Reckamp KL, Burgio MA, Kohlhäeufl M, Waterhouse D, Barlesi F, Antonia S, Arrieta O, Fayette J, Crinò L, Rizvi N, Reck M, Hellmann MD, Geese WJ, Li A, Blackwood-Chirchir A, Healey D, Brahmer J, Eberhardt WEE.

J Clin Oncol. 2017 Dec 10;35(35):3924-3933. doi: 10.1200/JCO.2017.74.3062. Epub 2017 Oct 12.

PMID: 29023213

Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists.

Wilson RJ, Jecs E, Miller EJ, Nguyen HH, Tahirovic YA, Truax VM, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Paiva AA, Schroeder GM, Wilson LJ, Liotta DC.

ACS Med Chem Lett. 2017 Dec 8;9(1):17-22. doi: 10.1021/acsmedchemlett.7b00381. eCollection 2018 Jan 11.

PMID: 29348805

Symptom Onset in Aortic Stenosis: Relation to Sex Differences in Left Ventricular Remodeling.

Singh A, Chan DCS, Greenwood JP, Dawson DK, Sonecki P, Hogrefe K, Kelly DJ, Dhakshinamurthy V, Lang CC, Khoo JP, Sprigings D, Steeds RP, Zhang R, Ford I, Jerosch-Herold M, Yang J, Li Z, Ng LL, McCann GP.

JACC Cardiovasc Imaging. 2017 Dec 8. pii: S1936-878X(17)30987-7. doi: 10.1016/j.jcmg.2017.09.019. [Epub ahead of print]

PMID: 29248646

Dapagliflozin as add-on therapy in Asian patients with type 2 diabetes inadequately controlled on insulin with or without oral antihyperglycemic drugs: A randomized controlled trial.

Yang W, Ma J, Li Y, Li Y, Zhou Z, Kim JH, Zhao J, Ptaszynska A.

J Diabetes. 2017 Dec 7. doi: 10.1111/1753-0407.12634. [Epub ahead of print]

PMID: 29215189

 

Codon-Directed Determination of the Biological Causes of Sequence Variants in Therapeutic Proteins.

Jiang T, Song H, Slaney TR, Wu W, Langsdorf E, Gupta G, Ludwig R, Tao L, McVey D, Das TK.

Anal Chem. 2017 Dec 5;89(23):12749-12755. doi: 10.1021/acs.analchem.7b02914. Epub 2017 Nov 14.

PMID: 29086552

 

Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study.

Mann J, Dressman J, Rosenblatt K, Ashworth L, Muenster U, Frank K, Hutchins P, Williams J, Klumpp L, Wielockx K, Berben P, Augustijns P, Holm R, Hofmann M, Patel S, Beato S, Ojala K, Tomaszewska I, Bruel JL, Butler J.

Mol Pharm. 2017 Dec 4;14(12):4192-4201. doi: 10.1021/acs.molpharmaceut.7b00198. Epub 2017 Aug 23.

PMID: 28737403

Pharmacokinetics and Pharmacodynamics of Atazanavir in HIV-1-Infected Children Treated With Atazanavir Powder and Ritonavir: Combined Analysis of the PRINCE-1 and -2 Studies.

Sevinsky H, Zaru L, Wang R, Xu X, Pikora C, Correll TA, Eley T.

Pediatr Infect Dis J. 2017 Dec 4. doi: 10.1097/INF.0000000000001855. [Epub ahead of print]

PMID: 29206748

 

Treatment patterns and clinical outcomes with pazopanib in patients with advanced soft tissue sarcomas in a compassionate use setting: results of the SPIRE study.

Gelderblom H, Judson IR, Benson C, Merimsky O, Grignani G, Katz D, Freivogel KW, Stein D, Jobanputra M, Mungul A, Manson SC, Sanfilippo R.

Acta Oncol. 2017 Dec;56(12):1769-1775. doi: 10.1080/0284186X.2017.1332779. Epub 2017 Jul 19.

PMID: 28723233

Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial.

Melloni C, Dunning A, Granger CB, Thomas L, Khouri MG, Garcia DA, Hylek EM, Hanna M, Wallentin L, Gersh BJ, Douglas PS, Alexander JH, Lopes RD.

Am J Med. 2017 Dec;130(12):1440-1448.e1. doi: 10.1016/j.amjmed.2017.06.026. Epub 2017 Jul 21.

PMID: 28739198

 

Ten-year outcomes in a randomized phase II study of kidney transplant recipients administered belatacept 4-weekly or 8-weekly.

Vincenti F, Blancho G, Durrbach A, Grannas G, Grinyó J, Meier-Kriesche HU, Polinsky M, Yang L, Larsen CP.

Am J Transplant. 2017 Dec;17(12):3219-3227. doi: 10.1111/ajt.14452. Epub 2017 Sep 5.

PMID: 28758341

2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelines & biomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays).

Gupta S, Richards S, Amaravadi L, Piccoli S, Desilva B, Pillutla R, Stevenson L, Mehta D, Carrasco-Triguero M, Neely R, Partridge M, Staack RF, Zhao X, Gorovits B, Kolaitis G, Sumner G, Stubenrauch KG, Zou L, Amur S, Beaver C, Berger I, Berisha F, Birnboeck H, Bower J, Cho SJ, Cludts I, Cocea L, Donato LD, Fischer S, Fraser S, Garofolo F, Haidar S, Haulenbeek J, Hottenstein C, Hu J, Ishii-Watabe A, Islam R, Jani D, Kadavil J, Kamerud J, Kramer D, Kurki P, MacMannis S, McNally J, Mullan A, Papadimitriou A, Pedras-Vasconcelos J, Ray S, Safavi A, Saito Y, Savoie N, Fjording MS, Scheibner K, Smeraglia J, Song A, Stouffer B, Tampal N, der Strate BV, Verch T, Welink J, Xu Y, Yang TY, Yengi L, Zeng J, Zhang Y, Zhang Y, Zoog S.

Bioanalysis. 2017 Dec;9(24):1967-1996. doi: 10.4155/bio-2017-4974. Epub 2017 Dec 5.

PMID: 29205064

2017 White Paper: rise of hybrid LBA/LCMS immunogenicity assays (Part 2: hybrid LBA/LCMS biotherapeutics, biomarkers & immunogenicity assays and regulatory agencies' inputs).

Neubert H, Song A, Lee A, Wei C, Duggan J, Xu K, Woolf E, Evans C, Palandra J, Laterza O, Amur S, Berger I, Bustard M, Cancilla M, Chen SC, Cho SJ, Ciccimaro E, Cludts I, Cocea L, D'Arienzo C, Danan-Leon L, Donato LD, Garofolo F, Haidar S, Ishii-Watabe A, Jiang H, Kadavil J, Kassim S, Kurki P, Blaye OL, Liu K, Mathews R, Lima Santos GM, Niwa M, Pedras-Vasconcelos J, Qian M, Rago B, Saad O, Saito Y, Savoie N, Su D, Szapacs M, Tampal N, Vinter S, Wang J, Welink J, Whale E, Wilson A, Xue YJ.

Bioanalysis. 2017 Dec;9(23):1895-1912. doi: 10.4155/bio-2017-4973. Epub 2017 Dec 5.

PMID: 29205053

Analytical considerations for quantitative LC-MS strategies for measuring antibody drug-target engagement in tissues.

Shipkova P, Ciccimaro E, Olah TV.

Bioanalysis. 2017 Dec;9(23):1845-1847. doi: 10.4155/bio-2017-0215. Epub 2017 Nov 24. No abstract available.

PMID: 29171760

 

CRISPR-DAV: CRISPR NGS data analysis and visualization pipeline.

Wang X, Tilford C, Neuhaus I, Mintier G, Guo Q, Feder JN, Kirov S.

Bioinformatics. 2017 Dec 1;33(23):3811-3812. doi: 10.1093/bioinformatics/btx518.

PMID: 28961906

Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads.

Donnell AF, Zhang Y, Stang EM, Wei DD, Tebben AJ, Perez HL, Schroeder GM, Pan C, Rao C, Borzilleri RM, Vite GD, Gangwar S.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5267-5271. doi: 10.1016/j.bmcl.2017.10.028. Epub 2017 Oct 16.

PMID: 29102228

Combination of CD40 Agonism and CSF-1R Blockade Reconditions Tumor-Associated Macrophages and Drives Potent Antitumor Immunity.

Wiehagen KR, Girgis NM, Yamada DH, Smith AA, Chan SR, Grewal IS, Quigley M, Verona RI.

Cancer Immunol Res. 2017 Dec;5(12):1109-1121. doi: 10.1158/2326-6066.CIR-17-0258. Epub 2017 Nov 2.

PMID: 29097420

 

Efficacy and safety of entecavir versus lamivudine over 5 years of treatment: A randomized controlled trial in Korean patients with hepatitis B e antigen-negative chronic hepatitis B.

Lee KS, Kweon YO, Um SH, Kim BH, Lim YS, Paik SW, Heo J, Lee HJ, Kim DJ, Kim TH, Lee YS, Byun KS, Kim D, Lee MS, Yu K, Suh DJ.

Clin Mol Hepatol. 2017 Dec;23(4):331-339. doi: 10.3350/cmh.2016.0040. Epub 2017 Sep 26.

PMID: 28946736

Body mass index and clinical response to intravenous or subcutaneous abatacept in patients with rheumatoid arthritis.

D'Agostino MA, Alten R, Mysler E, Le Bars M, Ye J, Murthy B, Heitzmann J, Vadanici R, Ferraccioli G.

Clin Rheumatol. 2017 Dec;36(12):2655-2665. doi: 10.1007/s10067-017-3788-1. Epub 2017 Aug 18.

PMID: 28822046

Use of Hybrid Capillary Tube Apparatus on 400 MHz NMR for Quantitation of Crucial Low-Quantity Metabolites Using aSICCO Signal.

Tiwari R, Ahire D, Kumar H, Sinha S, Chauthe SK, Subramanian M, Iyer R, Sarabu R, Bajpai L.

Drug Metab Dispos. 2017 Dec;45(12):1215-1224. doi: 10.1124/dmd.117.077073. Epub 2017 Sep 21.

PMID: 28935657

CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma.

Escudier B, Sharma P, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, Castellano D, Gurney H, Donskov F, Peltola K, Wagstaff J, Gauler TC, Ueda T, Zhao H, Waxman IM, Motzer RJ; CheckMate 025 investigators.

Eur Urol. 2017 Dec;72(6):962-971. doi: 10.1016/j.eururo.2017.02.010. Epub 2017 Mar 3. Erratum in: Eur Urol. 2018 Jan 3;:.

PMID: 28262413

Pooled Analysis Safety Profile of Nivolumab and Ipilimumab Combination Therapy in Patients With Advanced Melanoma.

Sznol M, Ferrucci PF, Hogg D, Atkins MB, Wolter P, Guidoboni M, Lebbé C, Kirkwood JM, Schachter J, Daniels GA, Hassel J, Cebon J, Gerritsen W, Atkinson V, Thomas L, McCaffrey J, Power D, Walker D, Bhore R, Jiang J, Hodi FS, Wolchok JD.

J Clin Oncol. 2017 Dec 1;35(34):3815-3822. doi: 10.1200/JCO.2016.72.1167. Epub 2017 Sep 15.

PMID: 28915085

Efficacy and Safety Outcomes in Patients With Advanced Melanoma Who Discontinued Treatment With Nivolumab and Ipilimumab Because of Adverse Events: A Pooled Analysis of Randomized Phase II and III Trials.

Schadendorf D, Wolchok JD, Hodi FS, Chiarion-Sileni V, Gonzalez R, Rutkowski P, Grob JJ, Cowey CL, Lao CD, Chesney J, Robert C, Grossmann K, McDermott D, Walker D, Bhore R, Larkin J, Postow MA.

J Clin Oncol. 2017 Dec 1;35(34):3807-3814. doi: 10.1200/JCO.2017.73.2289. Epub 2017 Aug 25.

PMID: 28841387

 

Safety and Efficacy of Nivolumab in Combination With Ipilimumab in Metastatic Renal Cell Carcinoma: The CheckMate 016

Study.

Hammers HJ, Plimack ER, Infante JR, Rini BI, McDermott DF, Lewis LD, Voss MH, Sharma P, Pal SK, Razak ARA, Kollmannsberger C, Heng DYC, Spratlin J, McHenry MB, Amin A.

J Clin Oncol. 2017 Dec 1;35(34):3851-3858. doi: 10.1200/JCO.2016.72.1985. Epub 2017 Jul 5.

PMID: 28678668

Exposure-Response Analysis of Nivolumab in Patients With Previously Treated or Untreated Advanced Melanoma.

Bajaj G, Gupta M, Feng Y, Statkevich P, Roy A.

J Clin Pharmacol. 2017 Dec;57(12):1527-1533. doi: 10.1002/jcph.962. Epub 2017 Aug 11. No abstract available.

PMID: 28800166

A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation.

Tang P, Xu J, Oliveira CL, Li ZJ, Liu S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):564-571. doi: 10.1080/14756366.2016.1275606.

PMID: 28114833

Daclatasvir/asunaprevir/beclabuvir, all-oral, fixed-dose combination for patients with chronic hepatitis C virus genotype 1.

Kao JH, Yu ML, Peng CY, Heo J, Chu CJ, Chang TT, Lee YJ, Hu TH, Yoon KT, Paik SW, Lim YS, Ahn SH, Isakov V, McPhee F, Hu W, Scott Swenson E, Yin PD, Treitel M.

J Gastroenterol Hepatol. 2017 Dec;32(12):1998-2005. doi: 10.1111/jgh.13796.

PMID: 28370350

IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.

Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C, Huang YH, Hamilton TA, Su B, Li X.

J Immunol. 2017 Dec 1;199(11):3849-3857. doi: 10.4049/jimmunol.1601540. Epub 2017 Oct 25.

PMID: 29070673

Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs.

Di L, Breen C, Chambers R, Eckley ST, Fricke R, Ghosh A, Harradine P, Kalvass JC, Ho S, Lee CA, Marathe P, Perkins EJ, Qian M, Tse S, Yan Z, Zamek-Gliszczynski MJ.

J Pharm Sci. 2017 Dec;106(12):3442-3452. doi: 10.1016/j.xphs.2017.09.005. Epub 2017 Sep 18. Review.

PMID: 28927987

Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.

Bristow LJ, Gulia J, Weed MR, Srikumar BN, Li YW, Graef JD, Naidu PS, Sanmathi C, Aher J, Bastia T, Paschapur M, Kalidindi N, Kumar KV, Molski T, Pieschl R, Fernandes A, Brown JM, Sivarao DV, Newberry K, Bookbinder M, Polino J, Keavy D, Newton A, Shields E, Simmermacher J, Kempson J, Li J, Zhang H, Mathur A, Kallem RR, Sinha M, Ramarao M, Vikramadithyan RK, Thangathirupathy S, Warrier J, Islam I, Bronson JJ, Olson RE, Macor JE, Albright CF, King D, Thompson LA, Marcin LR, Sinz M.

J Pharmacol Exp Ther. 2017 Dec;363(3):377-393. doi: 10.1124/jpet.117.242784. Epub 2017 Sep 27.

PMID: 28954811

Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma.

Morgan KM, Fischer BS, Lee FY, Shah JJ, Bertino JR, Rosenfeld J, Singh A, Khiabanian H, Pine SR.

Mol Cancer Ther. 2017 Dec;16(12):2759-2769. doi: 10.1158/1535-7163.MCT-17-0439. Epub 2017 Oct 4.

PMID: 28978720

Modelling the Survival Outcomes of Immuno-Oncology Drugs in Economic Evaluations: A Systematic Approach to Data Analysis and Extrapolation.

Gibson E, Koblbauer I, Begum N, Dranitsaris G, Liew D, McEwan P, Tahami Monfared AA, Yuan Y, Juarez-Garcia A, Tyas D, Lees M.

Pharmacoeconomics. 2017 Dec;35(12):1257-1270. doi: 10.1007/s40273-017-0558-5.

PMID: 28866758

Echocardiographic Risk Factors for Stroke and Outcomes in Patients With Atrial Fibrillation Anticoagulated With Apixaban or Warfarin.

Vinereanu D, Lopes RD, Mulder H, Gersh BJ, Hanna M, de Barros E Silva PGM, Atar D, Wallentin L, Granger CB, Alexander JH; ARISTOTLE Investigators.

Stroke. 2017 Dec;48(12):3266-3273. doi: 10.1161/STROKEAHA.117.017574. Epub 2017 Oct 31.

PMID: 29089455 

The effect of medication nonadherence on progression-free survival among patients with renal cell carcinoma.

Shafrin J, Sullivan J, Chou JW, Neely MN, Doan JF, Maclean JR.

Cancer Manag Res. 2017 Nov 29;9:731-739. doi: 10.2147/CMAR.S148199. eCollection 2017.

PMID: 29238223

On evaluation of consistency in multi-regional clinical trials.

Ying L, Song F, Chow SC, Zeng N, Zheng J, Li X, Henry D, Sethuraman V.

J Biopharm Stat. 2017 Nov 28:1-17. doi: 10.1080/10543406.2017.1397008. [Epub ahead of print]

PMID: 29182430

Ligand-accelerated non-directed C-H functionalization of arenes.

Wang P, Verma P, Xia G, Shi J, Qiao JX, Tao S, Cheng PTW, Poss MA, Farmer ME, Yeung KS, Yu JQ.

Nature. 2017 Nov 22;551(7681):489-493. doi: 10.1038/nature24632.

PMID: 29168802

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.

Puzanov I, Diab A, Abdallah K, Bingham CO 3rd, Brogdon C, Dadu R, Hamad L, Kim S, Lacouture ME, LeBoeuf NR, Lenihan D, Onofrei C, Shannon V, Sharma R, Silk AW, Skondra D, Suarez-Almazor ME, Wang Y, Wiley K, Kaufman HL, Ernstoff MS; Society for Immunotherapy of Cancer Toxicity Management Working Group.

J Immunother Cancer. 2017 Nov 21;5(1):95. doi: 10.1186/s40425-017-0300-z.

PMID: 29162153

Measurement of cAMP for Gαs- and Gαi Protein-Coupled Receptors (GPCRs).

Wang T, Li Z, Cvijic ME, Zhang L, Sum CS.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Hass JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2017 Nov 20.

PMID: 29165978

Measurement of β-Arrestin Recruitment for GPCR Targets.

Wang T, Li Z, Cvijic ME, Krause C, Zhang L, Sum CS.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Hass JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2017 Nov 20.

PMID: 29165975

Modernizing Clinical Trial Eligibility Criteria: Recommendations of the American Society of Clinical Oncology-Friends of Cancer Research Organ Dysfunction, Prior or Concurrent Malignancy, and Comorbidities Working Group.

Lichtman SM, Harvey RD, Damiette Smit MA, Rahman A, Thompson MA, Roach N, Schenkel C, Bruinooge SS, Cortazar P, Walker D, Fehrenbacher L.

J Clin Oncol. 2017 Nov 20;35(33):3753-3759. doi: 10.1200/JCO.2017.74.4102. Epub 2017 Oct 2.

PMID: 28968172

 

CITU: A Peptide and Decarboxylative Coupling Reagent.

deGruyter JN, Malins LR, Wimmer L, Clay KJ, Lopez-Ogalla J, Qin T, Cornella J, Liu Z, Che G, Bao D, Stevens JM, Qiao JX, Allen MP, Poss MA, Baran PS.

Org Lett. 2017 Nov 17;19(22):6196-6199. doi: 10.1021/acs.orglett.7b03121. Epub 2017 Nov 8.

PMID: 29115835

Effectiveness of current and future regimens for treating genotype 3 hepatitis C virus infection: a large-scale systematic review.

Fathi H, Clark A, Hill NR, Dusheiko G.

BMC Infect Dis. 2017 Nov 16;17(1):722. doi: 10.1186/s12879-017-2820-z. Review.

PMID: 29145802

Utilization of Standard and Target-Specific Oral Anticoagulants Among Adults in the United Kingdom With Incident Atrial Fibrillation.

Durham TA, Hassmiller Lich K, Viera AJ, Fine JP, Mukherjee J, Weinberger M, Dusetzina SB.

Am J Cardiol. 2017 Nov 15;120(10):1820-1829. doi: 10.1016/j.amjcard.2017.07.091. Epub 2017 Aug 12.

PMID: 28867127

Imaged capillary isoelectric focusing in native condition: A novel and successful example.

Zhang X, Chemmalil L, Ding J, Mussa N, Li Z.

Anal Biochem. 2017 Nov 15;537:13-19. doi: 10.1016/j.ab.2017.08.014. Epub 2017 Aug 24.

PMID: 28844814

Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor.

Cook J, Zusi FC, Hill MD, Fang H, Pearce B, Park H, Gallagher L, McDonald IM, Bristow L, Macor JE, Olson RE.

Bioorg Med Chem Lett. 2017 Nov 15;27(22):5002-5005. doi: 10.1016/j.bmcl.2017.10.009. Epub 2017 Oct 10.

PMID: 29050783

Identification and quantification of signal peptide variants in an IgG1 monoclonal antibody produced in mammalian cell lines.

Huang Y, Fu J, Ludwig R, Tao L, Bongers J, Ma L, Yao M, Zhu M, Das T, Russell R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:193-200. doi: 10.1016/j.jchromb.2017.08.046. Epub 2017 Oct 12.

PMID: 29078145

Enablement of the direct analysis of excipients in monoclonal antibody formulations through the incorporation of a wide pore C18 protein trap with hydrophilic interaction liquid chromatography.

Huang JZ, Lin S, Huang Z, Bolgar MS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:131-135. doi: 10.1016/j.jchromb.2017.10.034. Epub 2017 Oct 16.

PMID: 29059588 

Modelling the effect of beliefs about asthma medication and treatment intrusiveness on adherence and preference for once-daily vs. twice-daily medication.

Chapman S, Dale P, Svedsater H, Stynes G, Vyas N, Price D, Horne R.

NPJ Prim Care Respir Med. 2017 Nov 14;27(1):61. doi: 10.1038/s41533-017-0061-7.

PMID: 29138431

Racial differences in calculated bioavailable vitamin D with vitamin D/calcium supplementation.

Yin MT, Chan ES, Brown TT, Tebas P, McComsey GA, Melbourne KM, Napoli A, Hardin WR, Ribaudo HJ, Overton ET; A5280 Study Team.

AIDS. 2017 Nov 13;31(17):2337-2344. doi: 10.1097/QAD.0000000000001621.

PMID: 28832406

Conformation Preservation of α-Helical Peptides within Supramolecular Filamentous Assemblies.

Li Y, Wang Y, Ou SH, Lock LL, Xu X, Ghose S, Li ZJ, Cui H.

Biomacromolecules. 2017 Nov 13;18(11):3611-3620. doi: 10.1021/acs.biomac.7b00992. Epub 2017 Sep 27.

PMID: 28891286

Catabolic Effects of Human PTH (1-34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism.

Siddiqui JA, Johnson J, Le Henaff C, Bitel CL, Tamasi JA, Partridge NC.

Sci Rep. 2017 Nov 10;7(1):15300. doi: 10.1038/s41598-017-15563-7.

PMID:29127344

Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma.

Weber J, Mandala M, Del Vecchio M, Gogas HJ, Arance AM, Cowey CL, Dalle S, Schenker M, Chiarion-Sileni V, Marquez-Rodas I, Grob JJ, Butler MO, Middleton MR, Maio M, Atkinson V, Queirolo P, Gonzalez R, Kudchadkar RR, Smylie M, Meyer N, Mortier L, Atkins MB, Long GV, Bhatia S, Lebbé C, Rutkowski P, Yokota K, Yamazaki N, Kim TM, de Pril V, Sabater J, Qureshi A, Larkin J, Ascierto PA; CheckMate 238 Collaborators.

N Engl J Med. 2017 Nov 9;377(19):1824-1835. doi: 10.1056/NEJMoa1709030. Epub 2017 Sep 10.

PMID: 28891423

Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease.

Martyanov V, Kim GJ, Hayes W, Du S, Ganguly BJ, Sy O, Lee SK, Bogatkevich GS, Schieven GL, Schiopu E, Marangoni RG, Goldin J, Whitfield ML, Varga J.

PLoS One. 2017 Nov 9;12(11):e0187580. doi: 10.1371/journal.pone.0187580. eCollection 2017.

PMID: 29121645

 

Real-world evidence for nucleoside/nucleotide analogues in a 5-year multicentre study of antiviral-naive chronic hepatitis B patients in China: 52-week results.

Jia J, Tang H, Ning Q, Jiang J, Dou X, Zhang M, Zhang S, Shang J, Lu W, Ye Y, Wang X, Li M, Liu J, Bo Q, Tan W; EVOLVE Study Group.

Antivir Ther. 2017 Nov 8. doi: 10.3851/IMP. [Epub ahead of print]

PMID: 29116050

Transcriptome alterations of prefrontal cortical parvalbumin neurons in schizophrenia.

Enwright Iii JF, Huo Z, Arion D, Corradi JP, Tseng G, Lewis DA.

Mol Psychiatry. 2017 Nov 7. doi: 10.1038/mp.2017.216. [Epub ahead of print]

PMID: 29112193

Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab.

Riaz N, Havel JJ, Makarov V, Desrichard A, Urba WJ, Sims JS, Hodi FS, Martín-Algarra S, Mandal R, Sharfman WH, Bhatia S, Hwu WJ, Gajewski TF, Slingluff CL Jr, Chowell D, Kendall SM, Chang H, Shah R, Kuo F, Morris LGT, Sidhom JW, Schneck JP, Horak CE, Weinhold N, Chan TA.

Cell. 2017 Nov 2;171(4):934-949.e15. doi: 10.1016/j.cell.2017.09.028. Epub 2017 Oct 12.

PMID: 29033130

Recommendations for the Assessment and Management of Pre-existing Drug-Reactive Antibodies During Biotherapeutic Development.

Xue L, Clements-Egan A, Amaravadi L, Birchler M, Gorovits B, Liang M, Myler H, Purushothama S, Manning MS, Sung C.

AAPS J. 2017 Nov;19(6):1576-1586. doi: 10.1208/s12248-017-0153-x. Epub 2017 Nov 6.

PMID: 29110222

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys.

Morse BL, MacGuire JG, Marino AM, Zhao Y, Fox M, Zhang Y, Shen H, Griffith Humphreys W, Marathe P, Lai Y.

AAPS J. 2017 Nov;19(6):1878-1889. doi: 10.1208/s12248-017-0151-z. Epub 2017 Oct 10.

PMID: 29019117

Recommendations for Selection and Characterization of Protein Biomarker Assay Calibrator Material.

Cowan KJ, Amaravadi L, Cameron MJ, Fink D, Jani D, Kamat M, King L, Neely RJ, Ni Y, Rhyne P, Riffon R, Zhu Y.

AAPS J. 2017 Nov;19(6):1550-1563. doi: 10.1208/s12248-017-0146-9. Epub 2017 Oct 2.

PMID: 28971363

How Close Are We to Profiling Immunogenicity Risk Using In Silico Algorithms and In Vitro Methods?: an Industry Perspective.

Gokemeijer J, Jawa V, Mitra-Kaushik S.

AAPS J. 2017 Nov;19(6):1587-1592. doi: 10.1208/s12248-017-0143-z. Epub 2017 Oct 2.

PMID: 28971356

Approaches for Establishing Clinically Relevant Dissolution Specifications for Immediate Release Solid Oral Dosage Forms.

Hermans A, Abend AM, Kesisoglou F, Flanagan T, Cohen MJ, Diaz DA, Mao Y, Zhang L, Webster GK, Lin Y, Hahn DA, Coutant CA, Grady H.

AAPS J. 2017 Nov;19(6):1537-1549. doi: 10.1208/s12248-017-0117-1. Epub 2017 Aug 22.

PMID: 28831727

Prevalence of Co-existing Autoimmune Disease in Rheumatoid Arthritis: A Cross-Sectional Study.

Simon TA, Kawabata H, Ray N, Baheti A, Suissa S, Esdaile JM.

Adv Ther. 2017 Nov;34(11):2481-2490. doi: 10.1007/s12325-017-0627-3. Epub 2017 Oct 24.

PMID: 29067557

First-line treatment selection and early monitoring patterns in chronic phase-chronic myeloid leukemia in routine clinical practice: SIMPLICITY.

Goldberg SL, Cortes JE, Gambacorti-Passerini C, Hehlmann R, Khoury HJ, Michallet M, Paquette RL, Simonsson B, Zyczynski T, Foreman A, Abruzzese E, Andorsky D, Beeker A, Cony-Makhoul P, Hansen R, Lomaia E, Olavarria E, Mauro MJ.

Am J Hematol. 2017 Nov;92(11):1214-1223. doi: 10.1002/ajh.24887. Epub 2017 Sep 25.

PMID:  28815757

2017 White Paper on recent issues in bioanalysis: aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: small molecules, peptides and small molecule biomarkers).

Welink J, Yang E, Hughes N, Rago B, Woolf E, Sydor J, Coppola L, Ackermann B, Li W, Alley SC, Arnold M, Berger I, Briscoe C, Buonarati M, Bustard M, Cancilla M, Cho SJ, Duggan J, Fraier D, Garofolo F, Green R, Haidar S, Hittle L, Ishii-Watabe A, Islam R, Jenkins R, Jones B, Kadavil J, Kassim S, Kavetska O, Blaye OL, Lee A, Liu H, Mehl J, Lima Santos GM, Musuku A, Ramanathan R, Saito Y, Savoie N, Summerfield S, Surapaneni S, Szapacs M, Tampal N, Verhaeghe T, Vinter S, Whale E.

Bioanalysis. 2017 Nov;9(22):1807-1825. doi: 10.4155/bio-2017-4975. Epub 2017 Nov 17.

PMID: 29148835

 

Enantioselective supercritical fluid chromatography-tandem mass spectrometry method for simultaneous estimation of risperidone and its 9-hydroxyl metabolites in rat plasma.

Prasad TR, Joseph S, Kole P, Kumar A, Subramanian M, Rajagopalan S, Kr P.

Bioanalysis. 2017 Nov;9(22):1739-1750. doi: 10.4155/bio-2017-0168. Epub 2017 Nov 9.

PMID: 29120220

The future of immunocapture-capillary electrophoresis-high resolution mass spectrometry.

Wang L, Dodge RW, Ji QC.

Bioanalysis. 2017 Nov;9(21):1627-1631. doi: 10.4155/bio-2017-4977. Epub 2017 Nov 2. No abstract available.

PMID: 29095042

Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.

Bhide RS, Keon A, Weigelt C, Sack JS, Schmidt RJ, Lin S, Xiao HY, Spergel SH, Kempson J, Pitts WJ, Carman J, Poss MA.

Bioorg Med Chem Lett. 2017 Nov 1;27(21):4908-4913. doi: 10.1016/j.bmcl.2017.09.029. Epub 2017 Sep 18.

PMID: 28947151

pH variations during diafiltration due to buffer nonidealities.

Baek Y, Yang D, Singh N, Arunkumar A, Ghose S, Li ZJ, Zydney AL.

Biotechnol Prog. 2017 Nov;33(6):1555-1560. doi: 10.1002/btpr.2544. Epub 2017 Sep 4.

PMID: 28840650

Comparative study of therapeutic antibody candidates derived from mini-pool and clonal cell lines.

Fan L, Rizzi G, Bierilo K, Tian J, Yee JC, Russell R, Das TK.

Biotechnol Prog. 2017 Nov;33(6):1456-1462. doi: 10.1002/btpr.2477. Epub 2017 May 2.

PMID: 28393481

A Blueprint to Advance Colorectal Cancer Immunotherapies.

Le DT, Hubbard-Lucey VM, Morse MA, Heery CR, Dwyer A, Marsilje TH, Brodsky AN, Chan E, Deming DA, Diaz LA Jr, Fridman WH, Goldberg RM, Hamilton SR, Housseau F, Jaffee EM, Kang SP, Krishnamurthi SS, Lieu CH, Messersmith W, Sears CL, Segal NH, Yang A, Moss RA, Cha E, O'Donnell-Tormey J, Roach N, Davis AQ, McAbee K, Worrall S, Benson AB.

Cancer Immunol Res. 2017 Nov;5(11):942-949. doi: 10.1158/2326-6066.CIR-17-0375. Epub 2017 Oct 16.

PMID: 29038296

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, Caldas C, Christie AL, Clark DA, Dowst H, Dry JR, Doroshow JH, Duchamp O, Evrard YA, Ferretti S, Frese KK, Goodwin NC, Greenawalt D, Haendel MA, Hermans E, Houghton PJ, Jonkers J, Kemper K, Khor TO, Lewis MT, Lloyd KCK, Mason J, Medico E, Neuhauser SB, Olson JM, Peeper DS, Rueda OM, Seong JK, Trusolino L, Vinolo E, Wechsler-Reya RJ, Weinstock DM, Welm A, Weroha SJ, Amant F, Pfister SM, Kool M, Parkinson H, Butte AJ, Bult CJ.

Cancer Res. 2017 Nov 1;77(21):e62-e66. doi: 10.1158/0008-5472.CAN-17-0582.

PMID: 29092942

Bleeding risk of apixaban, dabigatran, and low-dose rivaroxaban compared with warfarin in Japanese patients with non-valvular atrial fibrillation: a propensity matched analysis of administrative claims data.

Kohsaka S, Murata T, Izumi N, Katada J, Wang F, Terayama Y.

Curr Med Res Opin. 2017 Nov;33(11):1955-1963. doi: 10.1080/03007995.2017.1374935. Epub 2017 Sep 12.

PMID: 28857611

Phase II study of ipilimumab in adolescents with unresectable stage III or IV malignant melanoma.

Geoerger B, Bergeron C, Gore L, Sender L, Dunkel IJ, Herzog C, Brochez L, Cruz O, Nysom K, Berghorn E, Simsek B, Shen J, Pappo A.

Eur J Cancer. 2017 Nov;86:358-363. doi: 10.1016/j.ejca.2017.09.032. Epub 2017 Nov 5.

PMID: 29100190

Hepatitis C disease transmission and treatment uptake: impact on the cost-effectiveness of new direct-acting antiviral therapies.

Bennett H, Gordon J, Jones B, Ward T, Webster S, Kalsekar A, Yuan Y, Brenner M, McEwan P.

Eur J Health Econ. 2017 Nov;18(8):1001-1011. doi: 10.1007/s10198-016-0844-8. Epub 2016 Nov 1.

PMID:  27803989

A photochemical kinetic model for solid dosage forms.

Carvalho TC, La Cruz TE, Tábora JE.

Eur J Pharm Biopharm. 2017 Nov;120:63-72. doi: 10.1016/j.ejpb.2017.08.010. Epub 2017 Aug 20.

PMID: 28834735

Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model.

Zhang MZ, Wang X, Yang H, Fogo AB, Murphy BJ, Kaltenbach R, Cheng P, Zinker B, Harris RC.

J Am Soc Nephrol. 2017 Nov;28(11):3300-3311. doi: 10.1681/ASN.2017010107. Epub 2017 Jul 24.

PMID: 28739650

Incidence of dose escalation and impact on biologic costs among patients with rheumatoid arthritis treated with three intravenous agents.

Nadkarni A, McMorrow D, Patel C, Fowler R, Smith D.

J Comp Eff Res. 2017 Nov;6(8):671-682. doi: 10.2217/cer-2016-0090. Epub 2017 Aug 9.

PMID: 28791875

Comparing biologic persistence and healthcare costs in rheumatoid arthritis patients initiating subcutaneous biologics.

Nadkarni A, McMorrow D, Fowler R, Smith D.

J Comp Eff Res. 2017 Nov;6(8):659-669. doi: 10.2217/cer-2017-0010. Epub 2017 Aug 9.

PMID: 28791873

A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines.

Zhao Q, Kim T, Pang J, Sun W, Yang X, Wang J, Song Y, Zhang H, Sun H, Rangan V, Deshpande S, Tang H, Cvijic ME, Westhouse R, Olah T, Xie J, Struthers M, Salter-Cid L.

J Leukoc Biol. 2017 Nov;102(5):1271-1280. doi: 10.1189/jlb.5A0717-302. Epub 2017 Sep 12.

PMID: 28899907

Effect of Apixaban Versus Warfarin Use on Health Care Resource Utilization and Costs Among Elderly Patients with Nonvalvular Atrial Fibrillation.

Deitelzweig S, Luo X, Gupta K, Trocio J, Mardekian J, Curtice T, Lingohr-Smith M, Menges B, Lin J.

J Manag Care Spec Pharm. 2017 Nov;23(11):1191-1201. doi: 10.18553/jmcp.2017.17060. Epub 2017 Aug 11.

PMID: 29083968

Reply: Cost-effectiveness of combination daclatasvir-sofosbuvir for treatment of genotype 3 chronic hepatitis C infection in the United States.

Saint-Laurent Thibault C, Moorjaney D, Ganz ML, Sill B, Hede S, Yuan Y, Gorsh B.

J Med Econ. 2017 Nov;20(11):1123-1125. doi: 10.1080/13696998.2017.1360313. Epub 2017 Aug 11. No abstract available.

PMID: 28745536

Understanding the Delamination Risk of a Trilayer Tablet Using Minipiloting Tools.

Tao J, Robertson-Lavalle S, Pandey P, Badawy S.

J Pharm Sci. 2017 Nov;106(11):3346-3352. doi: 10.1016/j.xphs.2017.07.005. Epub 2017 Jul 16.

PMID: 28720384

Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen-Deuterium Exchange Mass Spectrometry, and Computational Analysis.

Yan Y, Wei H, Jusuf S, Krystek SR Jr, Chen J, Chen G, Ludwig RT, Tao L, Das TK.

J Pharm Sci. 2017 Nov;106(11):3222-3229. doi: 10.1016/j.xphs.2017.06.009. Epub 2017 Jun 17.

PMID: 28634122

Reversal of apixaban anticoagulation by four-factor prothrombin complex concentrates in healthy subjects: a randomized three-period crossover study.

Song Y, Wang Z, Perlstein I, Wang J, LaCreta F, Frost RJA, Frost C.

J Thromb Haemost. 2017 Nov;15(11):2125-2137. doi: 10.1111/jth.13815. Epub 2017 Oct 9.

PMID: 28846831

Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial.

Dandona P, Mathieu C, Phillip M, Hansen L, Griffen SC, Tschöpe D, Thorén F, Xu J, Langkilde AM; DEPICT-1 Investigators.

Lancet Diabetes Endocrinol. 2017 Nov;5(11):864-876. doi: 10.1016/S2213-8587(17)30308-X. Epub 2017 Sep 14. Erratum in: Lancet Diabetes Endocrinol. 2017 Dec;5(12 ):e8.

PMID: 28919061

Forced degradation of recombinant monoclonal antibodies: A practical guide.

Nowak C, K Cheung J, M Dellatore S, Katiyar A, Bhat R, Sun J, Ponniah G, Neill A, Mason B, Beck A, Liu H.

MAbs. 2017 Nov/Dec;9(8):1217-1230. doi: 10.1080/19420862.2017.1368602. Epub 2017 Aug 30.

PMID: 28853987 

Determination of process variables affecting drug particle attrition withinmulti-component blends during powder feed transmission.

Gamble JF, Dennis AB, Hutchins P, Jones JW, Musembi P, Tobyn M.

Pharm Dev Technol. 2017 Nov;22(7):904-909. doi: 10.1080/10837450.2016.1200616. Epub 2016 Jun 27.

PMID: 27344924

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.

Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, Therrien M.

Nat Commun. 2017 Oct 31;8(1):1211. doi: 10.1038/s41467-017-01274-0.

PMID: 29084939

Lack of data sharing in observational studies.

McDonald L, Schultze A, Simpson A, Graham S, Wasiak R, Ramagopalan SV.

BMJ. 2017 Oct 24;359:j4866. doi: 10.1136/bmj.j4866. No abstract available.

PMID: 29066583 

Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties.

Subbaiah MAM, Meanwell NA, Kadow JF.

Eur J Med Chem. 2017 Oct 20;139:865-883. doi: 10.1016/j.ejmech.2017.07.044. Epub 2017 Jul 22. Review.

PMID: 28865281

Phase III Trial of Ipilimumab Combined With Paclitaxel and Carboplatin in Advanced Squamous Non-Small-Cell Lung Cancer.

Govindan R, Szczesna A, Ahn MJ, Schneider CP, Gonzalez Mella PF, Barlesi F, Han B, Ganea DE, Von Pawel J, Vladimirov V, Fadeeva N, Lee KH, Kurata T, Zhang L, Tamura T, Postmus PE, Jassem J, O'Byrne K, Kopit J, Li M, Tschaika M, Reck M.

J Clin Oncol. 2017 Oct 20;35(30):3449-3457. doi: 10.1200/JCO.2016.71.7629. Epub 2017 Aug 30.

PMID: 28854067

Societal preferences for adjuvant melanoma health states: UK and Australia.

Middleton MR, Atkins MB, Amos K, Wang PF, Kotapati S, Sabater J, Beusterien K.

BMC Cancer. 2017 Oct 17;17(1):689. doi: 10.1186/s12885-017-3673-y.

PMID: 29041898

Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.

Burchill MA, Roby JA, Crochet N, Wind-Rotolo M, Stone AE, Edwards MG, Dran RJ, Kriss MS, Gale M Jr, Rosen HR.

PLoS One. 2017 Oct 17;12(10):e0186213. doi: 10.1371/journal.pone.0186213. eCollection 2017.

PMID: 29040318

Real-world data really matter.

McDonald L, Ramagopalan SV, Lees M.

CMAJ. 2017 Oct 16;189(41):E1293. doi: 10.1503/cmaj.733383. No abstract available.

PMID: 29038323

Endogenous Biomarkers to Assess Drug-Drug Interactions by Drug Transporters and Enzymes.

Mariappan TT, Shen H, Marathe P.

Curr Drug Metab. 2017 Oct 16;18(8):757-768. doi: 10.2174/1389200218666170724110818.

PMID: 28738769

Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.

Wu YJ, Guernon J, McClure A, Luo G, Rajamani R, Ng A, Easton A, Newton A, Bourin C, Parker D, Mosure K, Barnaby O, Soars MG, Knox RJ, Matchett M, Pieschl R, Herrington J, Chen P, Sivarao DV, Bristow LJ, Meanwell NA, Bronson J, Olson R, Thompson LA, Dzierba C.

Bioorg Med Chem. 2017 Oct 15;25(20):5490-5505. doi: 10.1016/j.bmc.2017.08.012. Epub 2017 Aug 9

PMID: 28818462

Radiosynthesis and preclinical PET evaluation of 89Zr-nivolumab (BMS-936558) in healthy non-human primates.

Cole EL, Kim J, Donnelly DJ, Smith RA, Cohen D, Lafont V, Morin PE, Huang RY, Chow PL, Hayes W, Bonacorsi S Jr..

Bioorg Med Chem. 2017 Oct 15;25(20):5407-5414. doi: 10.1016/j.bmc.2017.07.066. Epub 2017 Aug 4.

PMID: 28803798

Discovery of highly potent, selective, covalent inhibitors of JAK3.

Kempson J, Ovalle D, Guo J, Wrobleski ST, Lin S, Spergel SH, Duan JJ, Jiang B, Lu Z, Das J, Yang BV, Hynes J Jr, Wu H, Tokarski J, Sack JS, Khan J, Schieven G, Blatt Y, Chaudhry C, Salter-Cid LM, Fura A, Barrish JC, Carter PH, Pitts WJ.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4622-4625. doi: 10.1016/j.bmcl.2017.09.023. Epub 2017 Sep 11.

PMID: 28927786

Setting priorities in the health care sector - the case of oral anticoagulants in nonvalvular atrial fibrillation in Denmark.

Poulsen PB, Johnsen SP, Hansen ML, Brandes A, Husted S, Harboe L, Dybro L.

Clinicoecon Outcomes Res. 2017 Oct 13;9:617-627. doi: 10.2147/CEOR.S145813. eCollection 2017.

PMID: 29066923

Characteristic rotational behaviors of rod-shaped cargo revealed by automated five-dimensional single particle tracking.

Chen K, Gu Y, Sun W, Bin Dong, Wang G, Fan X, Xia T, Fang N.

Nat Commun. 2017 Oct 12;8(1):887. doi: 10.1038/s41467-017-01001-9.

PMID: 29026088

Epidemiology, patient profile, and health care resource use for hepatitis C in Italy.

Sangiorgi D, Perrone V, Buda S, Boglione L, Cariti G, Lefevre C, Nappi C, Degli Esposti L.

Clinicoecon Outcomes Res. 2017 Oct 10;9:609-616. doi: 10.2147/CEOR.S136456. eCollection 2017.

PMID:  29066922

Oral anticoagulant persistence in patients with non-valvular atrial fibrillation: A cohort study using primary care data in Germany.

Collings SL, Lefèvre C, Johnson ME, Evans D, Hack G, Stynes G, Maguire A.

PLoS One. 2017 Oct 10;12(10):e0185642. doi: 10.1371/journal.pone.0185642. eCollection 2017.

PMID: 29016695

IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.

Zhou H, Bulek K, Li X, Herjan T, Yu M, Qian W, Wang H, Zhou G, Chen X, Yang H, Hong L, Zhao J, Qin L, Fukuda K, Flotho A, Gao J, Dongre A, Carman JA, Kang Z, Su B, Kern TS, Smith JD, Hamilton TA, Melchior F, Fox PL, Li X.

Elife. 2017 Oct 9;6. pii: e29630. doi: 10.7554/eLife.29630.

PMID: 28990926

Treatment patterns and costs of care for patients with relapsed and refractory Hodgkin lymphoma treated with brentuximab vedotin in the United States: A retrospective cohort study.

Szabo SM, Hirji I, Johnston KM, Juarez-Garcia A, Connors JM.

PLoS One. 2017 Oct 9;12(10):e0180261. doi: 10.1371/journal.pone.0180261. eCollection 2017.

PMID: 28991893

Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097.

Mathur A, Wang B, Smith D, Li J, Pawluczyk J, Sun JH, Wong MK, Krishnananthan S, Wu DR, Sun D, Li P, Yip S, Chen BC, Baran PS, Chen Q, Lopez OD, Yong Z, Bender JA, Nguyen VN, Romine JL, Laurent DRS, Wang G, Kadow JF, Meanwell NA, Belema M, Zhao R.

J Org Chem. 2017 Oct 6;82(19):10376-10387. doi: 10.1021/acs.joc.7b01852. Epub 2017 Sep 14.

PMID: 28877441

A Mild, Functional Group Tolerant Addition of Organozinc Nucleophiles to N-Activated Quinolines and Isoquinolines.

Luzung MR, Dixon DD, Ortiz A, Guerrero CA, Ayers S, Ho J, Schmidt MA, Strotman NA, Eastgate MD.

J Org Chem. 2017 Oct 6;82(19):10715-10721. doi: 10.1021/acs.joc.7b01882. Epub 2017 Sep 7.

PMID: 28809492

Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.

Robertson AS, Iben LG, Wei C, Meredith JE Jr, Drexler DM, Banks M, Vite GD, Olson RE, Thompson LA, Albright CF, Ahlijanian MK, Toyn JH.

Eur J Pharmacol. 2017 Oct 5;812:104-112. doi: 10.1016/j.ejphar.2017.07.019. Epub 2017 Jul 8.

PMID: 28690193

A polychromatic turbidity microplate assay to distinguish discovery stage drug molecules with beneficial precipitation properties.

Morrison J, Nophsker M, Elzinga P, Donoso M, Park H, Haskell R.

Int J Pharm. 2017 Oct 5;531(1):24-34. doi: 10.1016/j.ijpharm.2017.07.086. Epub 2017 Aug 7.

PMID: 28797968

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.

Wolchok JD, Chiarion-Sileni V, Gonzalez R, Rutkowski P, Grob JJ, Cowey CL, Lao CD, Wagstaff J, Schadendorf D, Ferrucci PF, Smylie M, Dummer R, Hill A, Hogg D, Haanen J, Carlino MS, Bechter O, Maio M, Marquez-Rodas I, Guidoboni M, McArthur G, Lebbé C, Ascierto PA, Long GV, Cebon J, Sosman J, Postow MA, Callahan MK, Walker D, Rollin L, Bhore R, Hodi FS, Larkin J.

N Engl J Med. 2017 Oct 5;377(14):1345-1356. doi: 10.1056/NEJMoa1709684. Epub 2017 Sep 11.

PMID: 28889792

Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models.

Lewis KE, Selby MJ, Masters G, Valle J, Dito G, Curtis WR, Garcia R, Mink KA, Waggie KS, Holdren MS, Grosso JF, Korman AJ, Jure-Kunkel M, Dillon SR.

Oncoimmunology. 2017 Oct 4;7(1):e1377873. doi: 10.1080/2162402X.2017.1377873. eCollection 2017.

PMID: 29296539

Standard Curves Are Necessary to Determine Pharmacological Properties for Ligands in Functional Assays Using Competition Binding Technologies.

Burford NT, Watson J, Alt A.

Assay Drug Dev Technol. 2017 Oct/Nov;15(7):320-329. doi: 10.1089/adt.2017.811.

PMID: 29120673

Immunoaffinity LC-MS/MS for quantitative determination of a free and total protein target as a target engagement biomarker.

Zhang H, Gu H, Shipkova P, Ciccimaro E, Sun H, Zhao Q, Olah TV.

Bioanalysis. 2017 Oct;9(20):1573-1588. doi: 10.4155/bio-2017-0152. Epub 2017 Oct 26.

PMID: 29072496

Spotting of external calibration standards on blank dried blood spots as a resource-sparing protocol.

Nigam A, Kole P, Kurawattimath V, Mandlekar S, Subramanian M.

Bioanalysis. 2017 Oct;9(19):1441-1450. doi: 10.4155/bio-2017-0143. Epub 2017 Oct 21.

PMID: 29056076

Efficacy of Sequential Ipilimumab Monotherapy versus Best Supportive Care for Unresectable Locally Advanced/Metastatic Gastric or Gastroesophageal Junction Cancer.

Bang YJ, Cho JY, Kim YH, Kim JW, Di Bartolomeo M, Ajani JA, Yamaguchi K, Balogh A, Sanchez T, Moehler M.

Clin Cancer Res. 2017 Oct 1;23(19):5671-5678. doi: 10.1158/1078-0432.CCR-17-0025. Epub 2017 Jun 27.

PMID: 28655793

Elevated Cardiovascular Disease Risk in Patients With Chronic Myelogenous Leukemia Seen in Community-based Oncology Practices in the United States.

Coutinho AD, Makenbaeva D, Farrelly E, Landsman-Blumberg PB, Lenihan D.

Clin Lymphoma Myeloma Leuk. 2017 Oct;17(10):676-683. doi: 10.1016/j.clml.2017.06.011. Epub 2017 Jun 17.

PMID: 28729178

Population Pharmacokinetic Analysis of Daclatasvir in Subjects with Chronic Hepatitis C Virus Infection.

Chan P, Li H, Zhu L, Bifano M, Eley T, Osawa M, Ueno T, Hughes E, Bertz R, Garimella T, AbuTarif M.

Clin Pharmacokinet. 2017 Oct;56(10):1173-1183. doi: 10.1007/s40262-016-0504-2.

PMID: 28066880

Coccidioidomycosis in an Indoor-housed Rhesus Macaque (Macaca mulatta).

Kundu MC, Ringenberg MA, d'Epagnier DL, Haag HL, Maguire S.

Comp Med. 2017 Oct 1;67(5):452-455.

PMID: 28935008

Model-based Meta-Analysis on the Efficacy of Pharmacological Treatments for Idiopathic Pulmonary Fibrosis.

Chan P, Bax L, Chen C, Zhang N, Huang SP, Soares H, Rosen G, AbuTarif M.

CPT Pharmacometrics Syst Pharmacol. 2017 Oct;6(10):695-704. doi: 10.1002/psp4.12227. Epub 2017 Sep 7.

PMID: 28699195

Comparison of effectiveness and safety of treatment with apixaban vs. other oral anticoagulants among elderly nonvalvular atrial fibrillation patients.

Deitelzweig S, Luo X, Gupta K, Trocio J, Mardekian J, Curtice T, Lingohr-Smith M, Menges B, Lin J.

Curr Med Res Opin. 2017 Oct;33(10):1745-1754. doi: 10.1080/03007995.2017.1334638. Epub 2017 Aug 29.

PMID: 28849676

Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective.

Wong H, Bohnert T, Damian-Iordache V, Gibson C, Hsu CP, Krishnatry AS, Liederer BM, Lin J, Lu Q, Mettetal JT, Mudra DR, Nijsen MJMA, Schroeder P, Schuck E, Suryawanshi S, Trapa P, Tsai A, Wang H, Wu F.

Drug Discov Today. 2017 Oct;22(10):1447-1459. doi: 10.1016/j.drudis.2017.04.015. Epub 2017 May 2.

PMID: 28476536

Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.

Hariparsad N, Ramsden D, Palamanda J, Dekeyser JG, Fahmi OA, Kenny JR, Einolf H, Mohutsky M, Pardon M, Siu YA, Chen L, Sinz M, Jones B, Walsky R, Dallas S, Balani SK, Zhang G, Buckley D, Tweedie D.

Drug Metab Dispos. 2017 Oct;45(10):1049-1059. doi: 10.1124/dmd.116.074567. Epub 2017 Jun 23.

PMID: 28646080

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

Ewart L, Fabre K, Chakilam A, Dragan Y, Duignan DB, Eswaraka J, Gan J, Guzzie-Peck P, Otieno M, Jeong CG, Keller DA, de Morais SM, Phillips JA, Proctor W, Sura R, Van Vleet T, Watson D, Will Y, Tagle D, Berridge B.

Exp Biol Med (Maywood). 2017 Oct;242(16):1579-1585. doi: 10.1177/1535370217715441. Epub 2017 Jun 16.

PMID: 28622731

Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future.

Vezina HE, Cotreau M, Han TH, Gupta M.

J Clin Pharmacol. 2017 Oct;57 Suppl 10:S11-S25. doi: 10.1002/jcph.981.

PMID: 28921650

Clinical Pharmacology Considerations for the Development of Immune Checkpoint Inhibitors.

Sheng J, Srivastava S, Sanghavi K, Lu Z, Schmidt BJ, Bello A, Gupta M.

J Clin Pharmacol. 2017 Oct;57 Suppl 10:S26-S42. doi: 10.1002/jcph.990.

PMID: 28921644

The Utility of a Population Approach in Drug-Drug Interaction Assessments: A Simulation Evaluation.

Wang DD, Yu Y, Kassir N, Zhu M, Hanley WD, Earp JC, Chow AT, Gupta M, Hu C.

J Clin Pharmacol. 2017 Oct;57(10):1268-1278. doi: 10.1002/jcph.921. Epub 2017 May 17.

PMID: 28513856

Perspectives on Subcutaneous Route of Administration as an Immunogenicity Risk Factor for Therapeutic Proteins.

Hamuro L, Kijanka G, Kinderman F, Kropshofer H, Bu DX, Zepeda M, Jawa V.

J Pharm Sci. 2017 Oct;106(10):2946-2954. doi: 10.1016/j.xphs.2017.05.030. Epub 2017 May 31. Review.

PMID: 28576695

Suboptimal Anticoagulant Management in Japanese Patients with Nonvalvular Atrial Fibrillation Receiving Warfarin for Stroke Prevention.

Hirano T, Kaneko H, Mishina S, Wang F, Morita S.

J Stroke Cerebrovasc Dis. 2017 Oct;26(10):2102-2110. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.030. Epub 2017 May 19.

PMID: 28532651

The effect of body mass index on clinical response to abatacept as a first-line biologic for rheumatoid arthritis: 6-month results from the 2-year, observational, prospective ACTION study.

Mariette X, Alten R, Nüßlein HG, Galeazzi M, Lorenz HM, Cantagrel A, Chartier M, Poncet C, Rauch C, Le Bars M.

Joint Bone Spine. 2017 Oct;84(5):571-576. doi: 10.1016/j.jbspin.2016.10.011. Epub 2016 Dec 30.

PMID: 28043761

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

Pancera M, Lai YT, Bylund T, Druz A, Narpala S, O'Dell S, Schön A, Bailer RT, Chuang GY, Geng H, Louder MK, Rawi R, Soumana DI, Finzi A, Herschhorn A, Madani N, Sodroski J, Freire E, Langley DR, Mascola JR, McDermott AB, Kwong PD.

Nat Chem Biol. 2017 Oct;13(10):1115-1122. doi: 10.1038/nchembio.2460. Epub 2017 Aug 21.

PMID: 28825711

A functional genomics predictive network model identifies regulators of inflammatory bowel disease.

Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, Losic B, Shah H, Lee E, Wang M, Faith JJ, Kasarskis A, Brodmerkel C, Curran M, Das A, Friedman JR, Fukui Y, Humphrey MB, Iritani BM, Sibinga N, Tarrant TK, Argmann C, Hao K, Roussos P, Zhu J, Zhang B, Dobrin R, Mayer LF, Schadt EE.

Nat Genet. 2017 Oct;49(10):1437-1449. doi: 10.1038/ng.3947. Epub 2017 Sep 11.

PMID: 28892060

A randomized, open-label, Phase III clinical trial of nivolumab vs. therapy of investigator's choice in recurrent squamous cell carcinoma of the head and neck: A subanalysis of Asian patients versus the global population in checkmate 141.

Kiyota N, Hasegawa Y, Takahashi S, Yokota T, Yen CJ, Iwae S, Shimizu Y, Hong RL, Goto M, Kang JH, Sum Kenneth Li W, Ferris RL, Gillison M, Namba Y, Monga M, Lynch M, Tahara M.

Oral Oncol. 2017 Oct;73:138-146. doi: 10.1016/j.oraloncology.2017.07.023. Epub 2017 Sep 1.

PMID: 28939066

Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment.

Srikumar BN, Paschapur M, Kalidindi N, Adepu B, Das ML, Sreedhara MV, Kuchibhotla VK, Pieschl RL, Li YW, Ega DSP, Louis JV, Murugesan S, Naidu PS, Ramarao M, Bristow LJ, Vikramadithyan RK.

Pharmacol Biochem Behav. 2017 Oct;161:53-61. doi: 10.1016/j.pbb.2017.09.003. Epub 2017 Sep 11.

PMID: 28911960

Update of the budget impact analysis of the simplification to atazanavir + ritonavir + lamivudine dual therapy of HIV-positive patients receiving atazanavir-based triple therapies in Italy starting from data of the Atlas-M trial.

Restelli U, Fabbiani M, Di Giambenedetto S, Nappi C, Croce D.

Clinicoecon Outcomes Res. 2017 Sep 27;9:569-571. doi: 10.2147/CEOR.S143377. eCollection 2017. No abstract available.

PMID: 29026324

Cardiovascular outcomes among HIV-infected veterans receiving atazanavir.

LaFleur J, Bress AP, Rosenblatt L, Crook J, Sax PE, Myers J, Ritchings C.

AIDS. 2017 Sep 24;31(15):2095-2106. doi: 10.1097/QAD.0000000000001594.

PMID: 28692532

Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4-1BB).

Azpilikueta A, Bolaños E, Lang V, Labiano S, Aznar MA, Etxeberria I, Teijeira A, Rodriguez-Ruiz ME, Perez-Gracia JL, Jure-Kunkel M, Zapata JM, Rodriguez MS, Melero I.

Oncoimmunology. 2017 Sep 21;7(1):e1368605. doi: 10.1080/2162402X.2017.1368605. eCollection 2017.

PMID: 29296520

Unintended consequences of machine learning in medicine?

McDonald L, Ramagopalan SV, Cox AP, Oguz M.

F1000Res. 2017 Sep 19;6:1707. doi: 10.12688/f1000research.12693.1. eCollection 2017.

PMID: 29250316

A review of data sharing statements in observational studies published in the BMJ: A cross-sectional study.

McDonald L, Schultze A, Simpson A, Graham S, Wasiak R, Ramagopalan SV.

Version 2. F1000Res. 2017 Sep 19 [revised 2017 Jan 1];6:1708. doi: 10.12688/f1000research.12673.2. eCollection 2017.

PMID: 29167735

Decarboxylative Alkynylation.

Smith JM, Qin T, Merchant RR, Edwards JT, Malins LR, Liu Z, Che G, Shen Z, Shaw SA, Eastgate MD, Baran PS.

Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11906-11910. doi: 10.1002/anie.201705107. Epub 2017 Aug 1.

PMID: 28636185

Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by hepatitis C virus genotypes: A genome-wide association study.

Lee MH, Huang YH, Chen HY, Khor SS, Chang YH, Lin YJ, Jen CL, Lu SN, Yang HI, Nishida N, Sugiyama M, Mizokami M, Yuan Y, L'Italien G, Tokunaga K, Chen CJ; REVEAL-HCV Cohort Study Group.

Hepatology. 2017 Sep 16. doi: 10.1002/hep.29531. [Epub ahead of print]

PMID: 28921602

Nivolumab Exposure-Response Analyses of Efficacy and Safety in Previously Treated Squamous or Nonsquamous Non-Small Cell Lung Cancer.

Feng Y, Wang X, Bajaj G, Agrawal S, Bello A, Lestini B, Finckenstein FG, Park JS, Roy A.

Clin Cancer Res. 2017 Sep 15;23(18):5394-5405. doi: 10.1158/1078-0432.CCR-16-2842.

PMID: 28916617

Nonclinical and clinical pharmacology evidence for cardiovascular safety of saxagliptin.

Pollack PS, Chadwick KD, Smith DM, Billger M, Hirshberg B, Iqbal N, Boulton DW.

Cardiovasc Diabetol. 2017 Sep 13;16(1):113. doi: 10.1186/s12933-017-0595-6. Review.

PMID: 28903775 

Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme.

Goods BA, Hernandez AL, Lowther DE, Lucca LE, Lerner BA, Gunel M, Raddassi K, Coric V, Hafler DA, Love JC.

PLoS One. 2017 Sep 7;12(9):e0181538. doi: 10.1371/journal.pone.0181538. eCollection 2017.

PMID: 28880903

Biopharmaceutical Evaluation and CMC Aspects of Oral Modified Release Formulations.

Chang RK, Mathias N, Hussain MA.

AAPS J. 2017 Sep;19(5):1348-1358. doi: 10.1208/s12248-017-0112-6. Epub 2017 Jul 5.

PMID: 28681160

The Impact of Disintegrant Type, Surfactant, and API Properties on the Processability and Performance of Roller Compacted Formulations of Acetaminophen and Aspirin.

Zhao J, Koo O, Pan D, Wu Y, Morkhade D, Rana S, Saha P, Marin A.

AAPS J. 2017 Sep;19(5):1387-1395. doi: 10.1208/s12248-017-0104-6. Epub 2017 Jun 12.

PMID: 28608238

Singlicate Ligand Binding Assay Using an Automated Microfluidic System: a Clinical Case Study.

Jiang H, Kozhich A, Cummings J, Gambardella J, Zambito F, Titsch C, Haulenbeek J, Phillips K, Fergus R, Myler H.

AAPS J. 2017 Sep;19(5):1461-1468. doi: 10.1208/s12248-017-0105-5. Epub 2017 Jun 6.

PMID: 28589510

Belatacept-Resistant Rejection Is Associated With CD28+ Memory CD8 T Cells.

Mathews DV, Wakwe WC, Kim SC, Lowe MC, Breeden C, Roberts ME, Farris AB, Strobert EA, Jenkins JB, Larsen CP, Ford ML, Townsend R, Adams AB.

Am J Transplant. 2017 Sep;17(9):2285-2299. doi: 10.1111/ajt.14349. Epub 2017 Jul 11.

PMID: 28502128

Efficacy and safety of abatacept, a T-cell modulator, in a randomised, double-blind, placebo-controlled, phase III study in psoriatic arthritis.

Mease PJ, Gottlieb AB, van der Heijde D, FitzGerald O, Johnsen A, Nys M, Banerjee S, Gladman DD.

Ann Rheum Dis. 2017 Sep;76(9):1550-1558. doi: 10.1136/annrheumdis-2016-210724. Epub 2017 May 4.

PMID: 28473423

Technologies and strategies for bioanalysis of biopharmaceuticals.

Zhang YJ, An HJ.

Bioanalysis. 2017 Sep;9(18):1343-1347. doi: 10.4155/bio-2017-4981. No abstract available.

PMID: 28956635

Challenges and opportunities in bioanalytical support for gene therapy medicinal product development.

Ma M, Balasubramanian N, Dodge R, Zhang Y.

Bioanalysis. 2017 Sep;9(18):1423-1430. doi: 10.4155/bio-2017-0116. Epub 2017 Sep 18.

PMID: 28920452

Macrocyclic factor XIa inhibitors.

Wang C, Corte JR, Rossi KA, Bozarth JM, Wu Y, Sheriff S, Myers JE Jr, Luettgen JM, Seiffert DA, Wexler RR, Quan ML.

Bioorg Med Chem Lett. 2017 Sep 1;27(17):4056-4060. doi: 10.1016/j.bmcl.2017.07.048. Epub 2017 Jul 25.

PMID: 28780160

Ultrafiltration behavior of monoclonal antibodies and Fc-fusion proteins: Effects of physical properties.

Baek Y, Singh N, Arunkumar A, Borys M, Li ZJ, Zydney AL.

Biotechnol Bioeng. 2017 Sep;114(9):2057-2065. doi: 10.1002/bit.26326. Epub 2017 May 18.

PMID: 28464237

Elotuzumab plus lenalidomide/dexamethasone for relapsed or refractory multiple myeloma: ELOQUENT-2 follow-up and post-hoc analyses on progression-free survival and tumour growth.

Dimopoulos MA, Lonial S, White D, Moreau P, Palumbo A, San-Miguel J, Shpilberg O, Anderson K, Grosicki S, Spicka I, Walter-Croneck A, Magen H, Mateos MV, Belch A, Reece D, Beksac M, Bleickardt E, Poulart V, Sheng J, Sy O, Katz J, Singhal A, Richardson P.

Br J Haematol. 2017 Sep;178(6):896-905. doi: 10.1111/bjh.14787. Epub 2017 Jul 5.

PMID: 28677826

Focused microwave irradiation-assisted immunohistochemistry to study effects of ketamine on phospho-ERK expression in the mouse brain.

Fernandes A, Li YW.

Brain Res. 2017 Sep 1;1670:86-95. doi: 10.1016/j.brainres.2017.05.008. Epub 2017 May 10.

PMID: 28501494

Adenoma Prevalence in Blacks and Whites Having Equal Adherence To Screening Colonoscopy: The National Colonoscopy Study.

Mendelsohn RB, Winawer SJ, Jammula A, Mills G, Jordan P, O'Brien MJ, Close GM, Dorfman M, Church TR, Mandelson MT, Allen J, Feld A, Kauff ND, Morgan GA, Kumar JMR, Serrano V, Bayuga-Miller S, Fischer SE, Kuk D, Zauber AG.

Clin Gastroenterol Hepatol. 2017 Sep;15(9):1469-1470. doi: 10.1016/j.cgh.2017.04.014. Epub 2017 Apr 15.

PMID: 28419856

Developing a Natural History Progression Model for Duchenne Muscular Dystrophy Using the Six-Minute Walk Test.

Hamuro L, Chan P, Tirucherai G, AbuTarif M.

CPT Pharmacometrics Syst Pharmacol. 2017 Sep;6(9):596-603. doi: 10.1002/psp4.12220. Epub 2017 Aug 29.

PMID: 28643370

Risk of major bleeding in patients with non-valvular atrial fibrillation treated with oral anticoagulants: a systematic review of real-world observational studies.

Deitelzweig S, Farmer C, Luo X, Vo L, Li X, Hamilton M, Horblyuk R, Ashaye A.

Curr Med Res Opin. 2017 Sep;33(9):1583-1594. doi: 10.1080/03007995.2017.1347090. Epub 2017 Jul 6. Review.

PMID: 28644048

Risk of stroke/systemic embolism, major bleeding and associated costs in non-valvular atrial fibrillation patients who initiated apixaban, dabigatran or rivaroxaban compared with warfarin in the United States Medicare population.

Amin A, Keshishian A, Trocio J, Dina O, Le H, Rosenblatt L, Liu X, Mardekian J, Zhang Q, Baser O, Vo L.

Curr Med Res Opin. 2017 Sep;33(9):1595-1604. doi: 10.1080/03007995.2017.1345729. Epub 2017 Jul 11.

PMID: 28635338

Health-related quality of life results from the phase III CheckMate 067 study.

Schadendorf D, Larkin J, Wolchok J, Hodi FS, Chiarion-Sileni V, Gonzalez R, Rutkowski P, Grob JJ, Cowey CL, Lao C, Wagstaff J, Callahan MK, Postow MA, Smylie M, Ferrucci PF, Dummer R, Hill A, Taylor F, Sabater J, Walker D, Kotapati S, Abernethy A, Long GV.

Eur J Cancer. 2017 Sep;82:80-91. doi: 10.1016/j.ejca.2017.05.031. Epub 2017 Jun 23.

PMID: 28651159

Treatment Beyond Progression in Patients with Advanced Renal Cell Carcinoma Treated with Nivolumab in CheckMate 025.

Escudier B, Motzer RJ, Sharma P, Wagstaff J, Plimack ER, Hammers HJ, Donskov F, Gurney H, Sosman JA, Zalewski PG, Harmenberg U, McDermott DF, Choueiri TK, Richardet M, Tomita Y, Ravaud A, Doan J, Zhao H, Hardy H, George S.

Eur Urol. 2017 Sep;72(3):368-376. doi: 10.1016/j.eururo.2017.03.037. Epub 2017 Apr 12.

PMID:28410865

Hepatitis C viral load, genotype, and increased risk of developing end-stage renal disease: REVEAL-HCV study.

Lai TS, Lee MH, Yang HI, You SL, Lu SN, Wang LY, Yuan Y, L'Italien G, Chien KL, Chen CJ; REVEAL-HCV Study Group.

Hepatology. 2017 Sep;66(3):784-793. doi: 10.1002/hep.29192. Epub 2017 Jul 18.

PMID: 28370058

A Systematic Review and Pooled Analysis of Select Safety Parameters Among Normal Healthy Volunteers Taking Placebo in Phase 1 Clinical Trials.

Young TC, Srinivasan S, Vetter ML, Sethuraman V, Bhagwagar Z, Zwirtes R, Narasimhan P, Chuang T, Smyth BJ.

J Clin Pharmacol. 2017 Sep;57(9):1079-1087. doi: 10.1002/jcph.913. Epub 2017 May 16.

PMID: 28510323

Practical implications of using real-world evidence (RWE) in comparative effectiveness research: learnings from IMI-GetReal.

Makady A, Stegenga H, Ciaglia A, Debray TP, Lees M, Happich M, Ryll B, Abrams K, Thwaites R, Garner S, Jonsson P, Goettsch W.

J Comp Eff Res. 2017 Sep;6(6):485-490. doi: 10.2217/cer-2017-0044. Epub 2017 Aug 31.

PMID: 28857631

A systematic study of the effect of low pH acid treatment on anti-drug antibodies specific for a domain antibody therapeutic: Impact on drug tolerance, assay sensitivity and post-validation method assessment of ADA in clinical serum samples.

Kavita U, Duo J, Crawford SM, Liu R, Valcin J, Gleason C, Dong H, Gadkari S, Dodge RW, Pillutla RC, DeSilva BS.

J Immunol Methods. 2017 Sep;448:91-104. doi: 10.1016/j.jim.2017.06.002. Epub 2017 Jun 16.

PMID: 28625864

Evaluation of healthcare resource utilization and incremental economic burden of patients with chronic myeloid leukemia after disease progression to blast phase.

Jabbour EJ, Lin J, Siegartel LR, Lingohr-Smith M, Menges B, Makenbaeva D.

J Med Econ. 2017 Sep;20(9):1007-1012. doi: 10.1080/13696998.2017.1345750. Epub 2017 Jul 6.

PMID: 28681664

Major bleeding risk and healthcare economic outcomes of non-valvular atrial fibrillation patients newly-initiated with oral anticoagulant therapy in the real-world setting.

Lin J, Trocio J, Gupta K, Mardekian J, Lingohr-Smith M, Menges B, You M, Nadkarni A.

J Med Econ. 2017 Sep;20(9):952-961. doi: 10.1080/13696998.2017.1341902. Epub 2017 Jun 22.

PMID: 28604139

Radiation-agent combinations for glioblastoma: challenges in drug development and future considerations.

Kunos CA, Galanis E, Buchsbaum J, Shi Q, Strauss LC, Coleman CN, Ahmed MM.

J Neurooncol. 2017 Sep;134(3):551-557. doi: 10.1007/s11060-017-2458-0. Epub 2017 May 30. Review.

PMID: 28560665

Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.

Cheng Y, Chen S, Freeden C, Chen W, Zhang Y, Abraham P, Nelson DM, Humphreys WG, Gan J, Lai Y.

J Pharmacol Exp Ther. 2017 Sep;362(3):385-394. doi: 10.1124/jpet.117.242370. Epub 2017 Jun 23.

PMID: 28645914

High hepatitis C viral load and genotype 2 are strong predictors of chronic kidney disease.

Lai TS, Lee MH, Yang HI, You SL, Lu SN, Wang LY, Yuan Y, L'Italien G, Chien KL, Chen CJ; REVEAL-HCV Study Group.

Kidney Int. 2017 Sep;92(3):703-709. doi: 10.1016/j.kint.2017.03.021. Epub 2017 May 20.

PMID: 28532708

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study.

Overman MJ, McDermott R, Leach JL, Lonardi S, Lenz HJ, Morse MA, Desai J, Hill A, Axelson M, Moss RA, Goldberg MV, Cao ZA, Ledeine JM, Maglinte GA, Kopetz S, André T.

Lancet Oncol. 2017 Sep;18(9):1182-1191. doi: 10.1016/S1470-2045(17)30422-9. Epub 2017 Jul 19.

PMID: 28734759

Daclatasvir plus sofosbuvir, with or without ribavirin, for hepatitis C virus genotype 3 in a French early access programme.

Hézode C, Lebray P, De Ledinghen V, Zoulim F, Di Martino V, Boyer N, Larrey D, Botta-Fridlund D, Silvain C, Fontaine H, D'Alteroche L, Leroy V, Bourliere M, Hubert-Fouchard I, Guyader D, Rosa I, Nguyen-Khac E, Fedchuk L, Akremi R, Bennai Y, Filipovics A, Zhao Y, Bronowicki JP.

Liver Int. 2017 Sep;37(9):1314-1324. doi: 10.1111/liv.13383. Epub 2017 Mar 8.

PMID: 28177199

A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site.

Rajamani R, Wu S, Rodrigo I, Gao M, Low S, Megson L, Wensel D, Pieschl RL, Post-Munson DJ, Watson J, Langley DR, Ahlijanian MK, Bristow LJ, Herrington J.

Mol Pharmacol. 2017 Sep;92(3):310-317. doi: 10.1124/mol.117.108712. Epub 2017 Jun 23.

PMID: 28645932

Mold Control and Detection in Biological Drug Substance Manufacturing Facilities: An Industry Perspective.

Bawa A, Asefi S, Ramsey S, Arbesser-Rastburg C, Paul M, Leira F, Landeryou T, Reddy B, Murphy M, Daddis B, Bain D.

PDA J Pharm Sci Technol. 2017 Sep-Oct;71(5):413-420. doi: 10.5731/pdajpst.2016.007351. Epub 2017 Jun 16.

PMID: 28624776

Small Molecule PET Tracers in Drug Discovery.

Donnelly DJ.

Semin Nucl Med. 2017 Sep;47(5):454-460. doi: 10.1053/j.semnuclmed.2017.05.006. Review.

PMID: 28826520

Randomized Clinical Trial Design to Assess Abatacept in Resistant Nephrotic Syndrome.

Trachtman H, Gipson DS, Somers M, Spino C, Adler S, Holzman L, Kopp JB, Sedor J, Overfield S, Elegbe A, Maldonado M, Greka A.

Kidney Int Rep. 2017 Aug 31;3(1):115-121. doi: 10.1016/j.ekir.2017.08.013. eCollection 2018 Jan.

PMID: 29340321

 

Discrete particle modeling and micromechanical characterization of bilayer tablet compaction.

Yohannes B, Gonzalez M, Abebe A, Sprockel O, Nikfar F, Kiang S, Cuitiño AM.

Int J Pharm. 2017 Aug 30;529(1-2):597-607. doi: 10.1016/j.ijpharm.2017.07.032. Epub 2017 Jul 13.

PMID: 28713000

Palladium(II)-Catalyzed Site-Selective C(sp3 )-H Alkynylation of Oligopeptides: A Linchpin Approach for Oligopeptide-Drug

Conjugation.

Liu T, Qiao JX, Poss MA, Yu JQ.

Angew Chem Int Ed Engl. 2017 Aug 28;56(36):10924-10927. doi: 10.1002/anie.201706367. Epub 2017 Aug 7.

PMID: 28714148

Improving Accuracy, Diversity, and Speed with Prime Macrocycle Conformational Sampling.

Sindhikara D, Spronk SA, Day T, Borrelli K, Cheney DL, Posy SL.

J Chem Inf Model. 2017 Aug 28;57(8):1881-1894. doi: 10.1021/acs.jcim.7b00052. Epub 2017 Aug 8.

PMID: 28727915

Survival inequalities in patients with lung cancer in France: A nationwide cohort study (the TERRITOIRE Study).

Chouaïd C, Debieuvre D, Durand-Zaleski I, Fernandes J, Scherpereel A, Westeel V, Blein C, Gaudin AF, Ozan N, Leblanc S, Vainchtock A, Chauvin P, Cotté FE, Souquet PJ.

PLoS One. 2017 Aug 25;12(8):e0182798. doi: 10.1371/journal.pone.0182798. eCollection 2017.

PMID: 28841679

The Economic Burden of Small Cell Lung Cancer: A Systematic Review of the Literature.

Enstone A, Greaney M, Povsic M, Wyn R, Penrod JR, Yuan Y.

Pharmacoecon Open. 2017 Aug 18. doi: 10.1007/s41669-017-0045-0. [Epub ahead of print] Review.

PMID: 29623624

An analysis of characteristics of post-authorisation studies registered on the ENCePP EU PAS Register.

Carroll R, Ramagopalan SV, Cid-Ruzafa J, Lambrelli D, McDonald L.

Version 2. F1000Res. 2017 Aug 14 [revised 2017 Jan 1];6:1447. doi: 10.12688/f1000research.12198.2. eCollection 2017.

PMID: 29188016

Downstream Processing Technologies/Capturing and Final Purification : Opportunities for Innovation, Change, and Improvement. A Review of Downstream Processing Developments in Protein Purification.

Singh N, Herzer S.

Adv Biochem Eng Biotechnol. 2017 Aug 10. doi: 10.1007/10_2017_12. [Epub ahead of print]

PMID: 28795201

 

Hospitalisation costs of metastatic melanoma in France; the MELISSA study (MELanoma In hoSpital coSts Assessment).

Fernandes J, Bregman B, Combemale P, Amaz C, de Léotoing L, Vainchtock A, Gaudin AF.

BMC Health Serv Res. 2017 Aug 8;17(1):542. doi: 10.1186/s12913-017-2472-0.

PMID: 28789648

 

Characterization of Naturally Occurring NS5A and NS5B Polymorphisms in Patients Infected with HCV Genotype 3a Treated with Direct-Acting Antiviral Agents.

Bartolini B, Giombini E, Taibi C, Lionetti R, Montalbano M, Visco-Comandini U, D'Offizi G, Capobianchi MR, McPhee F, Garbuglia AR.

Viruses. 2017 Aug 7;9(8). pii: E212. doi: 10.3390/v9080212.

PMID: 28783119

 

Health-related quality-of-life implications of cardiovascular events in individuals with type 2 diabetes mellitus: A subanalysis from the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR)-TIMI 53 trial.

Briggs AH, Bhatt DL, Scirica BM, Raz I, Johnston KM, Szabo SM, Bergenheim K, Mukherjee J, Hirshberg B, Mosenzon O.

Diabetes Res Clin Pract. 2017 Aug;130:24-33. doi: 10.1016/j.diabres.2016.12.019. Epub 2017 Jan 23.

PMID: 28554140

An improved protocol for amino acid type-selective isotope labeling in insect cells.

Zhang Y, Wei H, Xie D, Calambur D, Douglas A, Gao M, Marsilio F, Metzler WJ, Szapiel N, Zhang P, Witmer MR, Mueller L, Hedin D.

J Biomol NMR. 2017 Aug;68(4):237-247. doi: 10.1007/s10858-017-0117-6. Epub 2017 Jul 15.

PMID: 28711957

Chromatoprobe as a sample-sparing technique for residual solvent analysis of drug discovery candidates by gas chromatography.

Poronsky CJ, Cutrone JQ.

J Pharm Anal. 2017 Aug;7(4):265-269. doi: 10.1016/j.jpha.2017.03.009. Epub 2017 Apr 3.

PMID: 29404048

Identification of biomarkers of response to abatacept in patients with SLE using deconvolution of whole blood transcriptomic data from a phase IIb clinical trial.

Bandyopadhyay S, Connolly SE, Jabado O, Ye J, Kelly S, Maldonado MA, Westhovens R, Nash P, Merrill JT, Townsend RM.

Lupus Sci Med. 2017 Jul 28;4(1):e000206. doi: 10.1136/lupus-2017-000206. eCollection 2017.

PMID: 29214034

Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors.

Siemers NO, Holloway JL, Chang H, Chasalow SD, Ross-MacDonald PB, Voliva CF, Szustakowski JD.

PLoS One. 2017 Jul 27;12(7):e0179726. doi: 10.1371/journal.pone.0179726. eCollection 2017.

PMID: 28749946

Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care.

Gillooly KM, Pulicicchio C, Pattoli MA, Cheng L, Skala S, Heimrich EM, McIntyre KW, Taylor TL, Kukral DW, Dudhgaonkar S, Nagar J, Banas D, Watterson SH, Tino JA, Fura A, Burke JR.

PLoS One. 2017 Jul 24;12(7):e0181782. doi: 10.1371/journal.pone.0181782. eCollection 2017.

PMID: 28742141

Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment.

Burack WR, Spence JM, Spence JP, Spence SA, Rock PJ, Shenoy GN, Shultz LD, Bankert RB, Bernstein SH.

Blood Adv. 2017 Jul 7;1(16):1263-1273. doi: 10.1182/bloodadvances.2017005892. eCollection 2017 Jul 11.

PMID: 29296768

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.

Parcella K, Eastman K, Yeung KS, Grant-Young KA, Zhu J, Wang T, Zhang Z, Yin Z, Parker D, Mosure K, Fang H, Wang YK, Lemm J, Zhuo X, Hanumegowda U, Liu M, Rigat K, Donoso M, Tuttle M, Zvyaga T, Haarhoff Z, Meanwell NA, Soars MG, Roberts SB, Kadow JF.

ACS Med Chem Lett. 2017 Jun 29;8(7):771-774. doi: 10.1021/acsmedchemlett.7b00211. eCollection 2017 Jul 13.

PMID: 28740615

The anti-SLAMF7 antibody elotuzumab mediates NK cell activation through both CD16-dependent and -independent mechanisms.

Pazina T, James AM, MacFarlane AW 4th, Bezman NA, Henning KA, Bee C, Graziano RF, Robbins MD, Cohen AD, Campbell KS.

Oncoimmunology. 2017 Jun 16;6(9):e1339853. doi: 10.1080/2162402X.2017.1339853. eCollection 2017.

PMID: 28932638

 

Overcoming interference with the detection of a stable isotopically labeled microtracer in the evaluation of beclabuvir absolute bioavailability using a concomitant microtracer approach.

Jiang H, Titsch C, Zeng J, Jones B, Joyce P, Gandhi Y, Turley W, Burrell R, Aubry AF, Arnold ME.

J Pharm Biomed Anal. 2017 Sep 5;143:9-16. doi: 10.1016/j.jpba.2017.04.030. Epub 2017 May 17.

PMID: 28544885

 

Impact of moisture and magnesium stearate functionality on manufacturability of wet granulated metformin tablets.

Kestur U, Desai D, Sharif S, Wong B, Guo H, Tang D, Chan S.

Pharm Dev Technol. 2017 Sep;22(6):715-723. doi: 10.3109/10837450.2015.1116562. Epub 2015 Nov 29.

PMID: 26616157

 

Tolerability of central nervous system symptoms among HIV-1 infected efavirenz users: analysis of patient electronic medical record data.

Rosenblatt L, Broder MS, Bentley TGK, Chang E, Reddy SR, Papoyan E, Myers J.

AIDS Care. 2017 Aug;29(8):1067-1073. doi: 10.1080/09540121.2017.1280123. Epub 2017 Feb 1.

PMID: 28147708

 

A multiplexed immunocapture liquid chromatography tandem mass spectrometry assay for the simultaneous measurement of myostatin and GDF-11 in rat serum using an automated sample preparation platform.

Zhao Y, Liu G, Zambito FC, Zhang YJ, DeSilva BS, Kozhich AT, Shen JX.

Anal Chim Acta. 2017 Aug 1;979:36-44. doi: 10.1016/j.aca.2017.04.028. Epub 2017 Apr 26.

PMID: 28599707

 

Evaluation of cardiovascular ischemic event rates in dasatinib-treated patients using standardized incidence ratios.

Saglio G, le Coutre P, Cortes J, Mayer J, Rowlings P, Mahon FX, Kroog G, Gooden K, Subar M, Shah NP.

Ann Hematol. 2017 Aug;96(8):1303-1313. doi: 10.1007/s00277-017-3012-z. Epub 2017 May 22.

PMID: 28534184

 

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Zheng BZ, D'Andrea SV, Hanumegowda U, Knipe JO, Mosure K, Zhuo X, Lemm JA, Liu M, Rigat KL, Wang YK, Fang H, Poronsky C, Cutrone J, Wu DR, Arunachalam PN, Balapragalathan TJ, Arumugam A, Mathur A, Meanwell NA, Gao M, Roberts SB, Kadow JF.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3294-3300. doi: 10.1016/j.bmcl.2017.06.024. Epub 2017 Jun 11.

PMID: 28633899

 

Role of regional absorption and gastrointestinal motility on variability in oral absorption of a model drug.

Narang AS, Balakrishnan A, Morrison J, Li J, Wang J, Gu H, Taylor K, Santone K, Ehrmann J, Beyer S, Lu X, Ketner R, Pizzano J, Orcutt T, Shields E, Dulac H, Aborn S, Batchelder M, Lentz K.

Eur J Pharm Biopharm. 2017 Aug;117:333-345. doi: 10.1016/j.ejpb.2017.04.026. Epub 2017 Apr 25.

PMID: 28455207

 

Lipophilic salts of poorly soluble compounds to enable high-dose lipidic SEDDS formulations in drug discovery.

Morgen M, Saxena A, Chen XQ, Miller W, Nkansah R, Goodwin A, Cape J, Haskell R, Su C, Gudmundsson O, Hageman M, Kumar A, Chowan GS, Rao A, Holenarsipur VK.

Eur J Pharm Biopharm. 2017 Aug;117:212-223. doi: 10.1016/j.ejpb.2017.04.021. Epub 2017 Apr 21.

PMID: 28438550

 

 A quantitative in silico model for predicting skin sensitization using a nearest neighbours approach within expert-derived structure-activity alert spaces.

Canipa SJ, Chilton ML, Hemingway R, Macmillan DS, Myden A, Plante JP, Tennant RE, Vessey JD, Steger-Hartmann T, Gould J, Hillegass J, Etter S, Smith BPC, White A, Sterchele P, De Smedt A, O'Brien D, Parakhia R.

J Appl Toxicol. 2017 Aug;37(8):985-995. doi: 10.1002/jat.3448. Epub 2017 Feb 28.

 

Influence of Meals and Glycemic Changes on QT Interval Dynamics.

Cirincione B, Sager PT, Mager DE.

J Clin Pharmacol. 2017 Aug;57(8):966-976. doi: 10.1002/jcph.933. Epub 2017 May 22.

PMID: 28543601

 

Model-Based Evaluation of Exenatide Effects on the QT Interval in Healthy Subjects Following Continuous IV Infusion.

Cirincione B, LaCreta F, Sager P, Mager DE.

J Clin Pharmacol. 2017 Aug;57(8):956-965. doi: 10.1002/jcph.882. Epub 2017 May 22.

PMID: 28543393

 

Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.

Hynes J Jr, Wu H, Kempson J, Duan JJ, Lu Z, Jiang B, Stachura S, Tokarski JS, Sack JS, Khan JA, Lippy JS, Zhang RF, Pitt S, Shen G, Gillooly K, McIntyre K, Carter PH, Barrish JC, Nadler SG, Salter-Cid LM, Fura A, Schieven GL, Pitts WJ, Wrobleski ST.

Bioorg Med Chem Lett. 2017 Jul 15;27(14):3101-3106. doi: 10.1016/j.bmcl.2017.05.043. Epub 2017 May 15.

PMID: 28539220

 

Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents.

Pieschl RL, Miller R, Jones KM, Post-Munson DJ, Chen P, Newberry K, Benitex Y, Molski T, Morgan D, McDonald IM, Macor JE, Olson RE, Asaka Y, Digavalli S, Easton A, Herrington J, Westphal RS, Lodge NJ, Zaczek R, Bristow LJ, Li YW.

Eur J Pharmacol. 2017 Jul 15;807:1-11. doi: 10.1016/j.ejphar.2017.04.024. Epub 2017 Apr 22.

PMID: 28438647

 

Identification of a host cell protein impurity in therapeutic protein, P1.

Ahluwalia D, Dhillon H, Slaney T, Song H, Boux H, Mehta S, Zhang L, Valdez A, Krishnamurthy G.

J Pharm Biomed Anal. 2017 Jul 15;141:32-38. doi: 10.1016/j.jpba.2017.03.065. Epub 2017 Apr 9.

PMID:28419935

 

LC-MS determination of triazolam and its hydroxy metabolites in mouse dried blood spots: application to transgenic mouse pharmacokinetic studies.

Kole P, Rao A, Kurawattimath V, Mandlekar S.

Bioanalysis. 2017 Jul 10. doi: 10.4155/bio-2017-0067. [Epub ahead of print]

PMID: 28692308

 

Efficacy and tolerability of the new autoinjected suspension of exenatide once weekly versus exenatide twice daily in patients with type 2 diabetes.

Wysham CH, Rosenstock J, Vetter ML, Dong F, Öhman P, Iqbal N.

Diabetes Obes Metab. 2017 Jul 7. doi: 10.1111/dom.13056. [Epub ahead of print]

PMID: 28685973

 

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT2C Receptor Agonists.

Carpenter J, Wang Y, Wu G, Feng J, Ye XY, Morales CL, Broekema M, Rossi KA, Miller KJ, Murphy BJ, Wu G, Malmstrom SE, Azzara AV, Sher PM, Fevig JM, Alt A, Bertekap RL Jr, Cullen MJ, Harper TM, Foster K, Luk E, Xiang Q, Grubb MF, Robl JA, Wacker DA.

J Med Chem. 2017 Jul 7. doi: 10.1021/acs.jmedchem.7b00385. [Epub ahead of print]

PMID: 28635286

 

Improving Robustness: In Situ Generation of a Pd(0) Catalyst for the Cyanation of Aryl Bromides.

Coombs JR, Fraunhoffer KJ, Simmons EM, Stevens JM, Wisniewski SR, Yu M.

J Org Chem. 2017 Jul 7;82(13):7040-7044. doi: 10.1021/acs.joc.7b01003. Epub 2017 Jun 22.

PMID: 28594174

 

Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics.

Li KS, Chen G, Mo J, Huang RY, Deyanova EG, Beno BR, O'Neil SR, Tymiak AA, Gross ML.

Anal Chem. 2017 Jul 6. doi: 10.1021/acs.analchem.7b01748. [Epub ahead of print]

PMID: 28621526

 

Integrating cytokines and angiogenic factors and tumour bulk with selected clinical criteria improves determination of prognosis in advanced renal cell carcinoma.

Zurita AJ, Gagnon RC, Liu Y, Tran HT, Figlin RA, Hutson TE, D'Amelio AM Jr, Sternberg CN, Pandite LN, Heymach JV.

Br J Cancer. 2017 Jul 6. doi: 10.1038/bjc.2017.206. [Epub ahead of print]

PMID: 28683470

 

Risk of major bleeding in patients with non-valvular atrial fibrillation treated with oral anticoagulants: a systematic review of real-world observational studies.

Deitelzweig S, Farmer C, Luo X, Vo L, Li X, Hamilton M, Horblyuk R, Ashaye A.

Curr Med Res Opin. 2017 Jul 6:1-12. doi: 10.1080/03007995.2017.1347090. [Epub ahead of print]

PMID: 28644048

 

Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.

Robertson AS, Iben LG, Wei C, Meredith JE Jr, Drexler DM, Banks M, Vite GD, Olson RE, Thompson LA, Albright CF, Ahlijanian MK, Toyn JH.

Eur J Pharmacol. 2017 Jul 6. pii: S0014-2999(17)30457-0. doi: 10.1016/j.ejphar.2017.07.019. [Epub ahead of print]

PMID: 28690193

 

Evaluation of healthcare resource utilization and incremental economic burden of patients with chronic myeloid leukemia after disease progression to blast phase.

Jabbour EJ, Lin J, Siegartel LR, Lingohr-Smith M, Menges B, Makenbaeva D.

J Med Econ. 2017 Jul 6:1-6. doi: 10.1080/13696998.2017.1345750. [Epub ahead of print]

PMID: 28681664

 

Biopharmaceutical Evaluation and CMC Aspects of Oral Modified Release Formulations.

Chang RK, Mathias N, Hussain MA.

AAPS J. 2017 Jul 5. doi: 10.1208/s12248-017-0112-6. [Epub ahead of print]

PMID: 28681160

 

Elotuzumab plus lenalidomide/dexamethasone for relapsed or refractory multiple myeloma: ELOQUENT-2 follow-up and post-hoc analyses on progression-free survival and tumour growth.

Dimopoulos MA, Lonial S, White D, Moreau P, Palumbo A, San-Miguel J, Shpilberg O, Anderson K, Grosicki S, Spicka I, Walter-Croneck A, Magen H, Mateos MV, Belch A, Reece D, Beksac M, Bleickardt E, Poulart V, Sheng J, Sy O, Katz J, Singhal A, Richardson P.

Br J Haematol. 2017 Jul 5. doi: 10.1111/bjh.14787. [Epub ahead of print]

PMID: 28677826

 

Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes.

Haas LT, Salazar SV, Smith LM, Zhao HR, Cox TO, Herber CS, Degnan AP, Balakrishnan A, Macor JE, Albright CF, Strittmatter SM.

Cell Rep. 2017 Jul 5;20(1):76-88. doi: 10.1016/j.celrep.2017.06.023.

PMID: 28683325

 

Safety and Efficacy of Nivolumab in Combination With Ipilimumab in Metastatic Renal Cell Carcinoma: The CheckMate 016 Study.

Hammers HJ, Plimack ER, Infante JR, Rini BI, McDermott DF, Lewis LD, Voss MH, Sharma P, Pal SK, Razak ARA, Kollmannsberger C, Heng DYC, Spratlin J, McHenry MB, Amin A.

J Clin Oncol. 2017 Jul 5:JCO2016721985. doi: 10.1200/JCO.2016.72.1985. [Epub ahead of print]

PMID: 28678668

 

Zinc Acetate-Promoted Buchwald-Hartwig Couplings of Heteroaromatic Amines.

Ayothiraman R, Rangaswamy S, Maity P, Simmons EM, Beutner GL, Janey J, Treitler DS, Eastgate MD, Vaidyanathan R.

J Org Chem. 2017 Jul 5. doi: 10.1021/acs.joc.7b01101. [Epub ahead of print]

PMID: 28677970

 

Overall Survival in Patients With Advanced Melanoma Who Received Nivolumab Versus Investigator's Choice Chemotherapy in CheckMate 037: A Randomized, Controlled, Open-Label Phase III Trial.

Larkin J, Minor D, D'Angelo S, Neyns B, Smylie M, Miller WH Jr, Gutzmer R, Linette G, Chmielowski B, Lao CD, Lorigan P, Grossmann K, Hassel JC, Sznol M, Daud A, Sosman J, Khushalani N, Schadendorf D, Hoeller C, Walker D, Kong G, Horak C, Weber J.

J Clin Oncol. 2017 Jul 3:JCO2016718023. doi: 10.1200/JCO.2016.71.8023. [Epub ahead of print]

PMID: 28671856

 

QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models.

Cheng Y, Thalhauser CJ, Smithline S, Pagidala J, Miladinov M, Vezina HE, Gupta M, Leil TA, Schmidt BJ.

AAPS J. 2017 Jul;19(4):1002-1016. doi: 10.1208/s12248-017-0100-x. Epub 2017 May 24.

PMID: 28540623

 

Identification of highly potent and selective PI3Kδ inhibitors.

Marcoux D, Qin LY, Ruan Z, Shi Q, Ruan Q, Weigelt C, Qiu H, Schieven G, Hynes J, Bhide R, Poss M, Tino J.

Bioorg Med Chem Lett. 2017 Jul 1;27(13):2849-2853. doi: 10.1016/j.bmcl.2017.01.077. Epub 2017 Feb 7.

PMID: 28209465

 

Delays in treatment intensification with oral antidiabetic drugs and risk of microvascular and macrovascular events in patients with poor glycaemic control: An individual patient simulation study.

Folse HJ, Mukherjee J, Sheehan JJ, Ward AJ, Pelkey RL, Dinh TA, Qin L, Kim J.

Diabetes Obes Metab. 2017 Jul;19(7):1006-1013. doi: 10.1111/dom.12913. Epub 2017 Mar 20.

PMID: 28211604

 

Efficacy and safety of autoinjected exenatide once-weekly suspension versus sitagliptin or placebo with metformin in patients with type 2 diabetes: The DURATION-NEO-2 randomized clinical study.

Gadde KM, Vetter ML, Iqbal N, Hardy E, Öhman P; DURATION-NEO-2 study investigators.

Diabetes Obes Metab. 2017 Jul;19(7):979-988. doi: 10.1111/dom.12908. Epub 2017 Mar 17.

PMID: 28205322

 

Economic Outcomes of First-Line Regimen Switching Among Stable Patients with HIV.

Rosenblatt L, Buikema AR, Seare J, Bengtson LGS, Johnson J, Cao F, Villasis-Keever A.

J Manag Care Spec Pharm. 2017 Jul;23(7):725-734. doi: 10.18553/jmcp.2017.16403. Epub 2017 Jun 5.

PMID: 28650246

 

Cost-effectiveness of combination daclatasvir-sofosbuvir for treatment of genotype 3 chronic hepatitis C infection in the United States.

Saint-Laurent Thibault C, Moorjaney D, Ganz ML, Sill B, Hede S, Yuan Y, Gorsh B.

J Med Econ. 2017 Jul;20(7):692-702. doi: 10.1080/13696998.2017.1307204. Epub 2017 Apr 20.

PMID: 28294645

 

Healthcare and economic burden of adverse events among patients with chronic myelogenous leukemia treated with BCR-ABL1 tyrosine kinase inhibitors.

Lin J, Makenbaeva D, Lingohr-Smith M, Bilmes R.

J Med Econ. 2017 Jul;20(7):687-691. doi: 10.1080/13696998.2017.1302947. Epub 2017 Mar 12.

PMID: 28287043

 

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43.

Wu W, Sun M, Chen F, Cao AT, Liu H, Zhao Y, Huang X, Xiao Y, Yao S, Zhao Q, Liu Z, Cong Y.

Mucosal Immunol. 2017 Jul;10(4):946-956. doi: 10.1038/mi.2016.114. Epub 2016 Dec 14.

PMID: 27966553

 

Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents.

Robertson AS, Majchrzak MJ, Smith CM, Gagnon RC, Devidze N, Banks GB, Little SC, Nabbie F, Bounous DI, DiPiero J, Jacobsen LK, Bristow LJ, Ahlijanian MK, Stimpson SA.

Neuromuscul Disord. 2017 Jul;27(7):635-645. doi: 10.1016/j.nmd.2017.05.009. Epub 2017 May 12.

PMID: 28554556

 

Cost per response for abatacept versus adalimumab in rheumatoid arthritis by ACPA subgroups in Germany, Italy, Spain, US and Canada.

Weijers L, Baerwald C, Mennini FS, Rodríguez-Heredia JM, Bergman MJ, Choquette D, Herrmann KH, Attinà G, Nappi C, Merino SJ, Patel C, Mtibaa M, Foo J.

Rheumatol Int. 2017 Jul;37(7):1111-1123. doi: 10.1007/s00296-017-3739-9. Epub 2017 May 30.

PMID: 28560470

 

The synthesis of [14 C]4-acetylphenylalanine, effect on cell viability, and assessment of protein incorporation in male rat hepatocytes.

Maxwell BD, Ly V, Brock B, Dodge R, Tirmenstein M, Calvano J.

J Labelled Comp Radiopharm. 2017 Jun 30;60(8):352-356. doi: 10.1002/jlcr.3499. Epub 2017 May 30.

PMID: 28273378

 

The syntheses of [13 C6 ] and [phenyl-14 C(U)]BMS-816336, an inhibitor of 11β-hydroxysteroid dehydrogenase type 1, for type 2 diabetes.

Maxwell BD.

J Labelled Comp Radiopharm. 2017 Jun 30;60(8):357-365. doi: 10.1002/jlcr.3500. Epub 2017 May 30.

PMID: 28273377

 

Self-Assembling Cyclic d,l-α-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents.

Zhao Y, Leman LJ, Search DJ, Garcia RA, Gordon DA, Maryanoff BE, Ghadiri MR.

ACS Cent Sci. 2017 Jun 28;3(6):639-646. doi: 10.1021/acscentsci.7b00154. Epub 2017 Jun 13.

PMID: 28691076

 

Efficacy of Sequential Ipilimumab Monotherapy vs Best Supportive Care For Unresectable Locally Advanced/Metastatic Gastric or Gastroesophageal Junction Cancer.

Bang YJ, Cho JY, Kim YH, Kim JW, Di Bartolomeo M, Ajani JA, Yamaguchi K, Balogh A, Sanchez T, Moehler M.

Clin Cancer Res. 2017 Jun 27. pii: clincanres.0025.2017. doi: 10.1158/1078-0432.CCR-17-0025. [Epub ahead of print]

PMID: 28655793

 

Integrating a post-column makeup pump into preparative supercritical fluid chromatography systems to address stability and recovery issues during purifications.

Bajpai L, Naidu H, Asokan K, Shaik KM, Kaspady M, Arunachalam PN, Wu DR, Mathur A, Sarabu R.

J Chromatogr A. 2017 Jun 27. pii: S0021-9673(17)30953-6. doi: 10.1016/j.chroma.2017.06.063. [Epub ahead of print]

PMID: 28687240

 

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial.

El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH Rd, Meyer T, Kang YK, Yeo W, Chopra A, Anderson J, Dela Cruz C, Lang L, Neely J, Tang H, Dastani HB, Melero I.

Lancet. 2017 Jun 24;389(10088):2492-2502. doi: 10.1016/S0140-6736(17)31046-2. Epub 2017 Apr 20.

PMID: 28434648

Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.

Corte JR, Yang W, Fang T, Wang Y, Osuna H, Lai A, Ewing WR, Rossi KA, Myers JE Jr, Sheriff S, Lou Z, Zheng JJ, Harper TW, Bozarth JM, Wu Y, Luettgen JM, Seiffert DA, Quan ML, Wexler RR, Lam PYS.

Bioorg Med Chem Lett. 2017 Jun 23. pii: S0960-894X(17)30660-1. doi: 10.1016/j.bmcl.2017.06.058. [Epub ahead of print]

PMID: 28687203

 

Developing a Natural History Progression Model for Duchenne Muscular Dystrophy using the Six Minute Walk Test.

Hamuro L, Chan P, Tirucherai G, AbuTarif M.

CPT Pharmacometrics Syst Pharmacol. 2017 Jun 23. doi: 10.1002/psp4.12220. [Epub ahead of print]

PMID: 28643370

 

Repeated Measurements of Cardiac Biomarkers in Atrial Fibrillation and Validation of the ABC Stroke Score Over Time.

Hijazi Z, Lindahl B, Oldgren J, Andersson U, Lindbäck J, Granger CB, Alexander JH, Gersh BJ, Hanna M, Harjola VP, Hylek EM, Lopes RD, Siegbahn A, Wallentin L.

J Am Heart Assoc. 2017 Jun 23;6(6). pii: e004851. doi: 10.1161/JAHA.116.004851.

PMID: 28645934

 

 Bile salt homeostasis in normal and Bsep gene knock out rats with single and repeated doses of troglitazone.

Cheng Y, Chen S, Freeden C, Chen W, Zhang Y, Abraham P, Nelson D, Humphreys WG, Gan J, Lai Y.

J Pharmacol Exp Ther. 2017 Jun 23. pii: jpet.117.242370. doi: 10.1124/jpet.117.242370. [Epub ahead of print]

PMID: 28645914

 

Nivolumab versus standard, single-agent therapy of investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141): health-related quality-of-life results from a randomised, phase 3 trial.

Harrington KJ, Ferris RL, Blumenschein G Jr, Colevas AD, Fayette J, Licitra L, Kasper S, Even C, Vokes EE, Worden F, Saba NF, Kiyota N, Haddad R, Tahara M, Grünwald V, Shaw JW, Monga M, Lynch M, Taylor F, DeRosa M, Morrissey L, Cocks K, Gillison ML, Guigay J.

Lancet Oncol. 2017 Jun 23. pii: S1470-2045(17)30421-7. doi: 10.1016/S1470-2045(17)30421-7. [Epub ahead of print]

PMID: 28651929

 

A functional NaV1.7-NavAb chimera with a reconstituted high affinity ProTx-II binding site.

Rajamani R, Wu S, Rodrigo I, Gao M, Low S, Megson L, Wensel D, Pieschl R, Post-Munson D, Watson J, Langley DR, Ahlijanian M, Bristow L, Herrington J.

Mol Pharmacol. 2017 Jun 23. pii: mol.117.108712. doi: 10.1124/mol.117.108712. [Epub ahead of print]

PMID: 28645932

 

Health-related quality of life results from the phase III CheckMate 067 study.

Schadendorf D, Larkin J, Wolchok J, Hodi FS, Chiarion-Sileni V, Gonzalez R, Rutkowski P, Grob JJ, Cowey CL, Lao C, Wagstaff J, Callahan MK, Postow MA, Smylie M, Ferrucci PF, Dummer R, Hill A, Taylor F, Sabater J, Walker D, Kotapati S, Abernethy A, Long GV.

Eur J Cancer. 2017 Jun 22;82:80-91. doi: 10.1016/j.ejca.2017.05.031. [Epub ahead of print]

PMID: 28651159

 

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.

Liu Q, Shi Q, Marcoux D, Batt DG, Cornelius L, Qin LY, Ruan Z, Neels J, Beaudoin-Bertrand M, Srivastava AS, Li L, Cherney RJ, Gong H, Watterson SH, Weigelt C, Gillooly KM, McIntyre KW, Xie JH, Obermeier MT, Fura A, Sleczka B, Stefanski K, Fancher RM, Padmanabhan S, Rp T, Kundu I, Rajareddy K, Smith R, Hennan JK, Xing D, Fan J, Levesque PC, Ruan Q, Pitt S, Zhang R, Pedicord D, Pan J, Yarde M, Lu H, Lippy J, Goldstine C, Skala S, Rampulla RA, Mathur A, Gupta A, Arunachalam PN, Sack JS, Muckelbauer JK, Cvijic ME, Salter-Cid LM, Bhide RS, Poss MA, Hynes J, Carter PH, Macor JE, Ruepp S, Schieven GL, Tino JA.

J Med Chem. 2017 Jun 22;60(12):5193-5208. doi: 10.1021/acs.jmedchem.7b00618. Epub 2017 Jun 5.

PMID: 28541707

 

Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.

Ye XY, Chen SY, Wu S, Yoon DS, Wang H, Hong Z, O'Connor SP, Li J, Li JJ, Kennedy LJ, Walker SJ, Nayeem A, Sheriff S, Camac DM, Ramamurthy V, Morin PE, Zebo R, Taylor JR, Morgan NN, Ponticiello RP, Harrity T, Apedo A, Golla R, Seethala R, Wang M, Harper TW, Sleczka BG, He B, Kirby M, Leahy DK, Li J, Hanson RL, Guo Z, Li YX, DiMarco JD, Scaringe R, Maxwell B, Moulin F, Barrish JC, Gordon DA, Robl JA.

J Med Chem. 2017 Jun 22;60(12):4932-4948. doi: 10.1021/acs.jmedchem.7b00211. Epub 2017 Jun 5.

PMID: 28537398

 

Major bleeding risk and healthcare economic outcomes of non-valvular atrial fibrillation patients newly-initiated with oral anticoagulant therapy in the real-world setting.

Lin J, Trocio J, Gupta K, Mardekian J, Lingohr-Smith M, Menges B, You M, Nadkarni A.

J Med Econ. 2017 Jun 22:1-10. doi: 10.1080/13696998.2017.1341902. [Epub ahead of print]

PMID: 28604139

 

First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer.

Carbone DP, Reck M, Paz-Ares L, Creelan B, Horn L, Steins M, Felip E, van den Heuvel MM, Ciuleanu TE, Badin F, Ready N, Hiltermann TJN, Nair S, Juergens R, Peters S, Minenza E, Wrangle JM, Rodriguez-Abreu D, Borghaei H, Blumenschein GR Jr, Villaruz LC, Havel L, Krejci J, Corral Jaime J, Chang H, Geese WJ, Bhagavatheeswaran P, Chen AC, Socinski MA; CheckMate 026 Investigators.

N Engl J Med. 2017 Jun 22;376(25):2415-2426. doi: 10.1056/NEJMoa1613493.

PMID: 28636851

 

Risk of stroke/systemic embolism, major bleeding and associated costs in non-valvular atrial fibrillation patients who initiated apixaban, dabigatran, or rivaroxaban compared with warfarin in the United States Medicare population.

Amin A, Keshishian A, Trocio J, Dina O, Le H, Rosenblatt L, Liu X, Mardekian J, Zhang Q, Baser O, Vo L.

Curr Med Res Opin. 2017 Jun 21:1-32. doi: 10.1080/03007995.2017.1345729. [Epub ahead of print]

PMID: 28635338

 

New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31stAnnual Meeting of the Society for Immunotherapy of Cancer, 2016.

Adusumilli PS, Cha E, Cornfeld M, Davis T, Diab A, Dubensky TW Jr, Evans E, Grogan JL, Irving BA, Leidner RS, Olwill SA, Soon-Shiong P, Triebel F, Tuck D, Bot A, Dansey RD, Drake CG, Freeman GJ, Ibrahim R, Patel S, Chen DS.

J Immunother Cancer. 2017 Jun 20;5:50. doi: 10.1186/s40425-017-0253-2. eCollection 2017. Review.

PMID: 28649381

 

Mapping the Binding Interface in a Non-covalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen/deuterium Exchange Mass Spectrometry and Computational Analysis.

Yan Y, Wei H, Jusuf S, Krystek SR Jr, Chen J, Chen G, Ludwig RT, Tao L, Das TK.

J Pharm Sci. 2017 Jun 17. pii: S0022-3549(17)30446-X. doi: 10.1016/j.xphs.2017.06.009. [Epub ahead of print]

PMID: 28634122

 

A systematic study of the effect of low pH acid treatment on anti-drug antibodies specific for a domain antibody therapeutic: Impact on drug tolerance, assay sensitivity and post-validation method assessment of ADA in clinical serum samples.

Kavita U, Duo J, Crawford SM, Liu R, Valcin J, Gleason C, Dong H, Gadkari S, Dodge RW, Pillutla RC, DeSilva BS.

J Immunol Methods. 2017 Jun 16. pii: S0022-1759(17)30242-9. doi: 10.1016/j.jim.2017.06.002. [Epub ahead of print]

PMID: 28625864

 

A Novel Lack-of-Fit Assessment as a System Suitability Test for Potency Assays.

Li R, Cai W, Zocher M.

PDA J Pharm Sci Technol. 2017 Jun 16. pii: pdajpst.2016.007369. doi: 10.5731/pdajpst.2016.007369. [Epub ahead of print]

PMID: 28624777

 

Clinical Efficacy and Post-Treatment Seromarkers Associated with the Risk of Hepatocellular Carcinoma among Chronic Hepatitis C Patients.

Lee MH, Huang CF, Lai HC, Lin CY, Dai CY, Liu CJ, Wang JH, Huang JF, Su WP, Yang HC, Kee KM, Yeh ML, Chuang PH, Hsu SJ, Huang CI, Kao JT, Chen CC, Chen SH, Jeng WJ, Yang HI, Yuan Y, Lu SN, Sheen IS, Liu CH, Peng CY, Kao JH, Yu ML, Chuang WL, Chen CJ.

Sci Rep. 2017 Jun 16;7(1):3718. doi: 10.1038/s41598-017-02313-y.

PMID: 28623331

 

Neutral macrocyclic factor VIIa inhibitors.

Wurtz NR, Parkhurst BL, DeLucca I, Glunz PW, Jiang W, Zhang X, Cheney DL, Bozarth JM, Rendina AR, Wei A, Harper T, Luettgen JM, Wu Y, Wong PC, Seiffert DA, Wexler RR, Priestley ES.

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2650-2654. doi: 10.1016/j.bmcl.2017.04.008. Epub 2017 Apr 19.

PMID: 28460818

 

The Humanistic Burden of Small Cell Lung Cancer (SCLC): A Systematic Review of Health-Related Quality of Life (HRQoL) Literature.

Bennett BM, Wells JR, Panter C, Yuan Y, Penrod JR.

Front Pharmacol. 2017 Jun 15;8:339. doi: 10.3389/fphar.2017.00339. eCollection 2017. Review.

PMID: 28663730

 

Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum.

Greenawalt DM, Liang WS, Saif S, Johnson J, Todorov P, Dulak A, Enriquez D, Halperin R, Ahmed A, Saveliev V, Carpten J, Craig D, Barrett JC, Dougherty B, Zinda M, Fawell S, Dry JR, Byth K.

Oncotarget. 2017 Jun 15. doi: 10.18632/oncotarget.18502. [Epub ahead of print]

PMID: 28644138

 

NMR in drug design.

Harner MJ, Mueller L, Robbins KJ, Reily MD.

Arch Biochem Biophys. 2017 Jun 13. pii: S0003-9861(17)30364-8. doi: 10.1016/j.abb.2017.06.005. [Epub ahead of print]

PMID: 28619618

 

Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues.

Majzner RG, Simon JS, Grosso JF, Martinez D, Pawel BR, Santi M, Merchant MS, Geoerger B, Hezam I, Marty V, Vielh P, Daugaard M, Sorensen PH, Mackall CL, Maris JM.

Cancer. 2017 Jun 13. doi: 10.1002/cncr.30724. [Epub ahead of print]

PMID: 28608950

 

The Impact of Disintegrant Type, Surfactant, and API Properties on the Processability and Performance of Roller Compacted Formulations of Acetaminophen and Aspirin.

Zhao J, Koo O, Pan D, Wu Y, Morkhade D, Rana S, Saha P, Marin A.

AAPS J. 2017 Jun 12. doi: 10.1208/s12248-017-0104-6. [Epub ahead of print]

PMID: 28608238

 

The Surprising Importance of Peptide Bond Contacts in Drug-Protein Interactions.

Parrish RM, Sitkoff DF, Cheney DL, Sherrill CD.

Chemistry. 2017 Jun 12;23(33):7887-7890. doi: 10.1002/chem.201701031. Epub 2017 May 23.

PMID: 28378374

 

Pooled analysis of HCV genotype 1 resistance-associated substitutions in NS5A, NS3 and NS5B pre- and post-treatment with 12 weeks of daclatasvir, asunaprevir and beclabuvir.

McPhee F, Hernandez D, Zhou N, Ueland J, Yu F, Vellucci V, Huang X, Wang X, Ishikawa H, Karino Y, Kumada H.

Antivir Ther. 2017 Jun 8. doi: 10.3851/IMP3177. [Epub ahead of print]

PMID: 28594332

 

High-Throughput Automation in Chemical Process Development.

Selekman JA, Qiu J, Tran K, Stevens J, Rosso V, Simmons E, Xiao Y, Janey J.

Annu Rev Chem Biomol Eng. 2017 Jun 7;8:525-547. doi: 10.1146/annurev-chembioeng-060816-101411. Epub 2017 May 1.

PMID: 28460183

 

Multivariate Analysis and Statistics in Pharmaceutical Process Research and Development.

Tabora JE, Domagalski N.

Annu Rev Chem Biomol Eng. 2017 Jun 7;8:403-426. doi: 10.1146/annurev-chembioeng-060816-101418. Epub 2017 Apr 17.

PMID: 28415862

 

Singlicate Ligand Binding Assay Using an Automated Microfluidic System: a Clinical Case Study.

Jiang H, Kozhich A, Cummings J, Gambardella J, Zambito F, Titsch C, Haulenbeek J, Phillips K, Fergus R, Myler H.

AAPS J. 2017 Jun 6. doi: 10.1208/s12248-017-0105-5. [Epub ahead of print]

PMID: 28589510

 

One Filter, One Sample, and the N- and O-Glyco(proteo)me: Toward a System to Study Disorders of Protein Glycosylation.

Skeene K, Walker M, Clarke G, Bergström E, Genever P, Ungar D, Thomas-Oates J.

Anal Chem. 2017 Jun 6;89(11):5840-5849. doi: 10.1021/acs.analchem.7b00143. Epub 2017 May 10.

PMID: 28453257

 

Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity.

Wensel D, Sun Y, Li Z, Zhang S, Picarillo C, McDonagh T, Fabrizio D, Cockett M, Krystal M, Davis J.

Antimicrob Agents Chemother. 2017 Jun 5. pii: AAC.00508-17. doi: 10.1128/AAC.00508-17. [Epub ahead of print]

PMID: 28584151

 

Effects of Mild to Severe Hepatic Impairment on the Pharmacokinetics of Sonidegib: A Multicenter, Open-Label, Parallel-Group Study.

Horsmans Y, Zhou J, Liudmila M, Golor G, Shibolet O, Quinlan M, Emotte C, Boss H, Castro H, Sellami D, Preston RA.

Clin Pharmacokinet. 2017 Jun 2. doi: 10.1007/s40262-017-0560-2. [Epub ahead of print]

PMID: 28577129

 

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.

Shen H, Chen W, Drexler DM, Mandlekar S, Holenarsipur VK, Shields EE, Langish R, Sidik K, Gan J, Humphreys WG, Marathe P, Lai Y.

Drug Metab Dispos. 2017 Jun 2. pii: dmd.117.075531. doi: 10.1124/dmd.117.075531. [Epub ahead of print]

PMID: 28576766

 

Effectiveness and safety of apixaban versus warfarin in non-valvular atrial fibrillation patients in "real-world" clinical practice. A propensity-matched analysis of 76,940 patients.

Li XS, Deitelzweig S, Keshishian A, Hamilton M, Horblyuk R, Gupta K, Luo X, Mardekian J, Friend K, Nadkarni A, Pan X, Lip GYH.

Thromb Haemost. 2017 Jun 2;117(6):1072-1082. doi: 10.1160/TH17-01-0068. Epub 2017 Mar 16.

PMID: 28300870

 

Understanding the Impact of Chemical Variability and Calibration Algorithms on Prediction of Solid Fraction of Roller Compacted Ribbons Using Near-Infrared (NIR) Spectroscopy.

Talwar S, Nunes C, Stevens T, Nesarikar V, Timmins P, Anderson CA, Drennen JK 3rd.

Appl Spectrosc. 2017 Jun;71(6):1209-1221. doi: 10.1177/0003702816671960. Epub 2016 Nov 4.

PMID: 27815436

 

Affinity extraction LC-MS for small-molecule drug quantification: considerations, challenges and potential applications.

Mehl JT.

Bioanalysis. 2017 Jun;9(11):845-847. doi: 10.4155/bio-2017-0094. Epub 2017 Jun 19. No abstract available.

PMID: 28627228

 

A carbon dioxide stripping model for mammalian cell culture in manufacturing scale bioreactors.

Xing Z, Lewis AM, Borys MC, Li ZJ.

Biotechnol Bioeng. 2017 Jun;114(6):1184-1194. doi: 10.1002/bit.26232. Epub 2017 Feb 15.

PMID: 27922179

 

Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy.

Lopes RD, Guimarães PO, Kolls BJ, Wojdyla DM, Bushnell CD, Hanna M, Easton JD, Thomas L, Wallentin L, Al-Khatib SM, Held C, Gabriel Melo de Barros E Silva P, Alexander JH, Granger CB, Diener HC.

Blood. 2017 Jun 1;129(22):2980-2987. doi: 10.1182/blood-2016-08-731638. Epub 2017 Mar 29.

PMID: 28356246

 

A window of opportunity for abatacept in RA: is disease duration an independent predictor of low disease activity/remission in clinical practice?

Harrold LR, Litman HJ, Connolly SE, Kelly S, Hua W, Alemao E, Rosenblatt L, Rebello S, Kremer JM.

Clin Rheumatol. 2017 Jun;36(6):1215-1220. doi: 10.1007/s10067-017-3588-7. Epub 2017 Mar 1.

PMID: 28251392

 

Systemic Treatment Patterns With Advanced or Recurrent Non-small Cell Lung Cancer in Japan: A Retrospective Hospital Administrative Database Study.

Wang F, Mishina S, Takai S, Le TK, Ochi K, Funato K, Matsuoka S, Ohe Y.

Clin Ther. 2017 Jun;39(6):1146-1160. doi: 10.1016/j.clinthera.2017.04.010. Epub 2017 May 18.

PMID: 28527959

 

 Dapagliflozin in patients with type 1 diabetes: A post hoc analysis of the effect of insulin dose adjustments on 24-hour continuously monitored mean glucose and fasting β-hydroxybutyrate levels in a phase IIa pilot study.

Henry RR, Dandona P, Pettus J, Mudaliar S, Xu J, Hansen L.

Diabetes Obes Metab. 2017 Jun;19(6):814-821. doi: 10.1111/dom.12882. Epub 2017 Mar 27.

PMID: 28098426

 

Coproporphyrin-I: A Fluorescent, Endogenous Optimal Probe Substrate for ABCC2 (MRP2) Suitable for Vesicle-Based MRP2 Inhibition Assay.

Gilibili RR, Chatterjee S, Bagul P, Mosure KW, Murali BV, Mariappan TT, Mandlekar S, Lai Y.

Drug Metab Dispos. 2017 Jun;45(6):604-611. doi: 10.1124/dmd.116.074740. Epub 2017 Mar 21.

PMID: 28325716

 

Metabolite Identification, Reaction Phenotyping, and Retrospective Drug-Drug Interaction Predictions of 17-Deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate.

Ahire D, Sinha S, Brock B, Iyer R, Mandlekar S, Subramanian M.

Drug Metab Dispos. 2017 Jun;45(6):676-685. doi: 10.1124/dmd.116.073940. Epub 2017 Mar 10.

PMID: 28283499

 

Safety, pharmacokinetics, and pharmacodynamics of BMS-986142, a novel reversible BTK inhibitor, in healthy participants.

Lee SK, Xing J, Catlett IM, Adamczyk R, Griffies A, Liu A, Murthy B, Nowak M.

Eur J Clin Pharmacol. 2017 Jun;73(6):689-698. doi: 10.1007/s00228-017-2226-2. Epub 2017 Mar 6.

PMID: 28265691

New medicinal products for chronic heart failure: advances in clinical trial design and efficacy assessment.

Cowie MR, Filippatos GS, Alonso Garcia MLA, Anker SD, Baczynska A, Bloomfield DM, Borentain M, Bruins Slot K, Cronin M, Doevendans PA, El-Gazayerly A, Gimpelewicz C, Honarpour N, Janmohamed S, Janssen H, Kim AM, Lautsch D, Laws I, Lefkowitz M, Lopez-Sendon J, Lyon AR, Malik FI, McMurray JJV, Metra M, Figueroa Perez S, Pfeffer MA, Pocock SJ, Ponikowski P, Prasad K, Richard-Lordereau I, Roessig L, Rosano GMC, Sherman W, Stough WG, Swedberg K, Tyl B, Zannad F, Boulton C, De Graeff P.

Eur J Heart Fail. 2017 Jun;19(6):718-727. doi: 10.1002/ejhf.809. Epub 2017 Mar 27. Review.

PMID: 28345190

 

Dasatinib versus imatinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia: a subanalysis of the DASISION 5-year final report.

Nakamae H, Fujisawa S, Ogura M, Uchida T, Onishi Y, Taniwaki M, Utsunomiya A, Matsue K, Takamatsu Y, Usuki K, Tanimoto M, Ishida Y, Ohashi K, Li L, Miyoshi M.

Int J Hematol. 2017 Jun;105(6):792-804. doi: 10.1007/s12185-017-2208-2. Epub 2017 Mar 24.

PMID: 28341918

 

Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC.

Lencioni R, Montal R, Torres F, Park JW, Decaens T, Raoul JL, Kudo M, Chang C, Ríos J, Boige V, Assenat E, Kang YK, Lim HY, Walters I, Llovet JM.

J Hepatol. 2017 Jun;66(6):1166-1172. doi: 10.1016/j.jhep.2017.01.012. Epub 2017 Jan 26.

PMID: 28131794

 

Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases.

Ma Z, Onorato JM, Chen L, Nelson DW, Yen CE, Cheng D.

J Lipid Res. 2017 Jun;58(6):1091-1099. doi: 10.1194/jlr.M073445. Epub 2017 Apr 18.

PMID: 28420705

 

Warfarin Management and Outcomes in Patients with Nonvalvular Atrial Fibrillation Within an Integrated Health Care System.

An J, Niu F, Zheng C, Rashid N, Mendes RA, Dills D, Vo L, Singh P, Bruno A, Lang DT, Le PT, Jazdzewski KP, Aranda G Jr.

J Manag Care Spec Pharm. 2017 Jun;23(6):700-712. doi: 10.18553/jmcp.2017.23.6.700.

PMID: 28530526

 

A High-Throughput Bioluminescent Assay to Monitor the Deamidation of Asparagine and Isomerization of Aspartate Residues in Therapeutic Proteins and Antibodies.

Hsiao K, Alves J, Patel R, Adams M, Nashine V, Goueli S.

J Pharm Sci. 2017 Jun;106(6):1528-1537. doi: 10.1016/j.xphs.2017.02.022. Epub 2017 Mar 2.

PMID: 28263844

 

Short-duration treatment for chronic hepatitis C virus with daclatasvir, asunaprevir, beclabuvir and sofosbuvir (FOURward study).

Sulkowski MS, Flamm S, Kayali Z, Lawitz EJ, Kwo P, McPhee F, Torbeyns A, Hughes EA, Swenson ES, Yin PD, Linaberry M.

Liver Int. 2017 Jun;37(6):836-842. doi: 10.1111/liv.13335. Epub 2017 Feb 2.

PMID: 27943563

 

Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model.

Han J, Dzierlenga AL, Lu Z, Billheimer DD, Torabzadeh E, Lake AD, Li H, Novak P, Shipkova P, Aranibar N, Robertson D, Reily MD, Lehman-McKeeman LD, Cherrington NJ.

Obesity (Silver Spring). 2017 Jun;25(6):1069-1076. doi: 10.1002/oby.21855. Epub 2017 Apr 28.

PMID: 28452429

 

Neurologic Serious Adverse Events Associated with Nivolumab Plus Ipilimumab or Nivolumab Alone in Advanced Melanoma, Including a Case Series of Encephalitis.

Larkin J, Chmielowski B, Lao CD, Hodi FS, Sharfman W, Weber J, Suijkerbuijk KPM, Azevedo S, Li H, Reshef D, Avila A, Reardon DA.

Oncologist. 2017 Jun;22(6):709-718. doi: 10.1634/theoncologist.2016-0487. Epub 2017 May 11.

PMID: 28495807

 

Improvements in Fatigue in 1536 Patients with Rheumatoid Arthritis and Correlation with Other Treatment Outcomes: A Post Hoc Analysis of Three Randomized Controlled Trials of Abatacept.

Gossec L, Ahdjoudj S, Alemao E, Strand V.

Rheumatol Ther. 2017 Jun;4(1):99-109. doi: 10.1007/s40744-017-0054-6. Epub 2017 Mar 1.

PMID: 28251584

 

Ischemic Stroke in Nonvalvular Atrial Fibrillation at Warfarin Initiation: Assessment via a Large Insurance Database.

Tepper PG, Liu X, Hamilton M, Mardekian J, Petkun W, Tan W, Singer DE.

Stroke. 2017 Jun;48(6):1487-1494. doi: 10.1161/STROKEAHA.116.015535. Epub 2017 Apr 26.

PMID: 28446621

 

Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human.

Haarhoff ZE, Kramer MA, Zvyaga TA, Zhang J, Bhutani P, Subramanian M, Rodrigues AD.

Xenobiotica. 2017 Jun;47(6):470-478. doi: 10.1080/00498254.2016.1203042. Epub 2016 Aug 8.

PMID: 27498589

 

Perspectives on Subcutaneous Route of Administration as an Immunogenicity Risk Factor for Therapeutic Proteins.

Hamuro L, Kijanka G, Kinderman F, Kropshofer H, Bu DX, Zepeda M, Jawa V.

J Pharm Sci. 2017 May 31. pii: S0022-3549(17)30422-7. doi: 10.1016/j.xphs.2017.05.030. [Epub ahead of print] Review.

PMID: 28576695

 

IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.

Wang C, Zhang CJ, Martin BN, Bulek K, Kang Z, Zhao J, Bian G, Carman JA, Gao J, Dongre A, Xue H, Miller SD, Qian Y, Hambardzumyan D, Hamilton T, Ransohoff RM, Li X.

Nat Commun. 2017 May 31;8:15508. doi: 10.1038/ncomms15508.

PMID: 28561022

 

Radiation-agent combinations for glioblastoma: challenges in drug development and future considerations.

Kunos CA, Galanis E, Buchsbaum J, Shi Q, Strauss LC, Coleman CN, Ahmed MM.

J Neurooncol. 2017 May 30. doi: 10.1007/s11060-017-2458-0. [Epub ahead of print] Review.

PMID: 28560665

 

Identification of leachables observed in the size exclusion chromatograms of a low concentration product stored in prefilled syringes.

Valente JJ, Peddicord MB, Rinaldi FA, Kelly KA, Bolgar MS.

J Pharm Biomed Anal. 2017 May 30;139:133-142. doi: 10.1016/j.jpba.2017.02.039. Epub 2017 Feb 22.

PMID: 28279928

 

Evaluation of automated Wes system as an analytical and characterization tool to support monoclonal antibody drug product development.

Wang J, Valdez A, Chen Y.

J Pharm Biomed Anal. 2017 May 30;139:263-268. doi: 10.1016/j.jpba.2016.12.024. Epub 2016 Dec 21.

PMID: 28069351

 

Peg-Interferon Lambda Treatment Induces Robust Innate and Adaptive Immunity in Chronic Hepatitis B Patients.

Phillips S, Mistry S, Riva A, Cooksley H, Hadzhiolova-Lebeau T, Plavova S, Katzarov K, Simonova M, Zeuzem S, Woffendin C, Chen PJ, Peng CY, Chang TT, Lueth S, De Knegt R, Choi MS, Wedemeyer H, Dao M, Kim CW, Chu HC, Wind-Rotolo M, Williams R, Cooney E, Chokshi S.

Front Immunol. 2017 May 29;8:621. doi: 10.3389/fimmu.2017.00621. eCollection 2017.

PMID: 28611778

 

Molecular properties associated with transporter-mediated drug disposition.

Varma MV, Lai Y, El-Kattan AF.

Adv Drug Deliv Rev. 2017 May 26. pii: S0169-409X(17)30070-4. doi: 10.1016/j.addr.2017.05.014. [Epub ahead of print]

PMID: 28554577

 

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.

Yeung KS, Beno BR, Parcella K, Bender JA, Grant-Young KA, Nickel A, Gunaga P, Anjanappa P, Bora RO, Selvakumar K, Rigat K, Wang YK, Liu M, Lemm J, Mosure K, Sheriff S, Wan C, Witmer M, Kish K, Hanumegowda U, Zhuo X, Shu YZ, Parker D, Haskell R, Ng A, Gao Q, Colston E, Raybon J, Grasela DM, Santone K, Gao M, Meanwell NA, Sinz M, Soars MG, Knipe JO, Roberts SB, Kadow JF.

J Med Chem. 2017 May 25;60(10):4369-4385. doi: 10.1021/acs.jmedchem.7b00328. Epub 2017 May 4.

PMID: 28430437

 

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.

Ramagopal UA, Liu W, Garrett-Thomson SC, Bonanno JB, Yan Q, Srinivasan M, Wong SC, Bell A, Mankikar S, Rangan VS, Deshpande S, Korman AJ, Almo SC.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4223-E4232. doi: 10.1073/pnas.1617941114. Epub 2017 May 8.

PMID: 28484017

 

High hepatitis C viral load and genotype 2 are strong predictors of chronic kidney disease.

Lai TS, Lee MH, Yang HI, You SL, Lu SN, Wang LY, Yuan Y, L'Italien G, Chien KL, Chen CJ; REVEAL-HCV Study Group.

Kidney Int. 2017 May 20. pii: S0085-2538(17)30216-8. doi: 10.1016/j.kint.2017.03.021. [Epub ahead of print]

PMID: 28532708

 

Suboptimal Anticoagulant Management in Japanese Patients with Nonvalvular Atrial Fibrillation Receiving Warfarin for Stroke Prevention.

Hirano T, Kaneko H, Mishina S, Wang F, Morita S.

J Stroke Cerebrovasc Dis. 2017 May 19. pii: S1052-3057(17)30204-5. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.030. [Epub ahead of print]

PMID: 28532651

 

Effect of Apixaban on All-Cause Death in Patients with Atrial Fibrillation: a Meta-Analysis Based on Imputed Placebo Effect.

Guimarães PO, Lopes RD, Wojdyla DM, Abdul-Rahim AH, Connolly SJ, Flaker GC, Wang J, Hanna M, Granger CB, Wallentin L, Lees KR, Alexander JH, McMurray JJV.

Cardiovasc Drugs Ther. 2017 May 18. doi: 10.1007/s10557-017-6728-z. [Epub ahead of print]

PMID: 28516318

 

An integrated epidemiological and neural net model of the warfarin effect in managed care patients.

Jacobs DM, Stefanovic F, Wilton G, Gomez-Caminero A, Schentag JJ.

Clin Pharmacol. 2017 May 18;9:55-64. doi: 10.2147/CPAA.S136243. eCollection 2017.

PMID: 28572740

 

Assessment of nivolumab benefit-risk profile of a 240-mg flat dose relative to a 3-mg/kg dosing regimen in patients with advanced tumors.

Zhao X, Suryawanshi S, Hruska M, Feng Y, Wang X, Shen J, Vezina HE, McHenry MB, Waxman IM, Achanta A, Bello A, Roy A, Agrawal S.

Ann Oncol. 2017 May 17. doi: 10.1093/annonc/mdx235. [Epub ahead of print]

PMID: 28520840

 

The Utility of a Population Approach in Drug-Drug Interaction Assessments: A Simulation Evaluation.

Wang DD, Yu Y, Kassir N, Zhu M, Hanley WD, Earp JC, Chow AT, Gupta M, Hu C.

J Clin Pharmacol. 2017 May 17. doi: 10.1002/jcph.921. [Epub ahead of print]

PMID: 28513856

 

Host Cell Protein Profiling by Targeted and Untargeted Analysis of Data Independent Acquisition Mass Spectrometry Data with Parallel Reaction Monitoring Verification.

Kreimer S, Gao Y, Ray S, Jin M, Tan Z, Mussa NA, Tao L, Li Z, Ivanov AR, Karger BL.

Anal Chem. 2017 May 16;89(10):5294-5302. doi: 10.1021/acs.analchem.6b04892. Epub 2017 Apr 26.

PMID: 28402653

 

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness.

Galani IE, Triantafyllia V, Eleminiadou EE, Koltsida O, Stavropoulos A, Manioudaki M, Thanos D, Doyle SE, Kotenko SV, Thanopoulou K, Andreakos E.

Immunity. 2017 May 16;46(5):875-890.e6. doi: 10.1016/j.immuni.2017.04.025.

PMID: 28514692

 

A Systematic Review and Pooled Analysis of Select Safety Parameters Among Normal Healthy Volunteers Taking Placebo in Phase 1 Clinical Trials.

Young TC, Srinivasan S, Vetter ML, Sethuraman V, Bhagwagar Z, Zwirtes R, Narasimhan P, Chuang T, Smyth BJ.

J Clin Pharmacol. 2017 May 16. doi: 10.1002/jcph.913. [Epub ahead of print]

PMID: 28510323

 

[3H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement.

Louis JV, Lu Y, Pieschl R, Tian Y, Hong Y, Dandapani K, Naidu S, Vikramadithyan RK, Dzierba C, Sarvasiddhi SK, Nara SJ, Bronson J, Macor JE, Albright C, Kostich W, Li YW.

Neuropharmacology. 2017 May 15;118:167-174. doi: 10.1016/j.neuropharm.2017.03.015. Epub 2017 Mar 15.

PMID: 28315351

 

Belatacept Resistant Rejection is Associated with CD28+ Memory CD8 T cells.

Mathews DV, Wakwe WC, Kim SC, Lowe MC, Breeden C, Roberts ME, Farris AB, Strobert EA, Jenkins JB, Larsen CP, Ford ML, Townsend R, Adams AB.

Am J Transplant. 2017 May 14. doi: 10.1111/ajt.14349. [Epub ahead of print]

PMID: 28502128

 

Modulation of Kv 11.1 (hERG) channels by 5-(((1H-indazol-5-yl)oxy)methyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine (ITP-2), a novel small molecule activator.

Sale H, Roy S, Warrier J, Thangathirupathy S, Vadari Y, Gopal SK, Krishnamurthy P, Ramarao M.

Br J Pharmacol. 2017 May 12. doi: 10.1111/bph.13859. [Epub ahead of print]

PMID: 28500657

 

Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide.

Gunaga P, Lloyd J, Mummadi S, Banerjee A, Dhondi NK, Hennan J, Subray V, Jayaram R, Rajugowda N, Umamaheshwar Reddy K, Kumaraguru D, Mandal U, Beldona D, Adisechen AK, Yadav N, Warrier J, Johnson JA, Sale H, Putlur SP, Saxena A, Chimalakonda A, Mandlekar S, Conder M, Xing D, Gupta AK, Gupta A, Rampulla R, Mathur A, Levesque P, Wexler RR, Finlay HJ.

J Med Chem. 2017 May 11;60(9):3795-3803. doi: 10.1021/acs.jmedchem.6b01889. Epub 2017 Apr 28.

PMID: 28418664

 

Decarboxylative alkenylation.

Edwards JT, Merchant RR, McClymont KS, Knouse KW, Qin T, Malins LR, Vokits B, Shaw SA, Bao DH, Wei FL, Zhou T, Eastgate MD, Baran PS.

Nature. 2017 May 11;545(7653):213-218. doi: 10.1038/nature22307. Epub 2017 Apr 19.

PMID: 28424520

 

Focused microwave irradiation-assisted immunohistochemistry to study effects of ketamine on phospho-ERK expression in the mouse brain.

Fernandes A, Li YW.

Brain Res. 2017 May 10. pii: S0006-8993(17)30204-4. doi: 10.1016/j.brainres.2017.05.008. [Epub ahead of print]

PMID: 28501494

 

Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development.

Qian Cutrone JJ, Huang XS, Kozlowski ES, Bao Y, Wang Y, Poronsky CS, Drexler DM, Tymiak AA.

J Pharm Biomed Anal. 2017 May 10;138:166-174. doi: 10.1016/j.jpba.2017.01.056. Epub 2017 Feb 3.

PMID: 28213177

 

Rate-Dependent Role of IKur in Human Atrial Repolarization and Atrial Fibrillation Maintenance.

Aguilar M, Feng J, Vigmond E, Comtois P, Nattel S.

Biophys J. 2017 May 9;112(9):1997-2010. doi: 10.1016/j.bpj.2017.03.022.

PMID: 28494969

 

4-Cyanobenzenesulfonamides: Amine Synthesis and Protecting Strategy To Compliment the Nosyl Group.

Schmidt MA, Stokes RW, Davies ML, Roberts F.

J Org Chem. 2017 May 5;82(9):4550-4560. doi: 10.1021/acs.joc.7b00608. Epub 2017 Apr 19.

PMID: 28410437

 

Synthesis of HIV-Maturation Inhibitor BMS-955176 from Betulin by an Enabling Oxidation Strategy.

Ortiz A, Soumeillant M, Savage SA, Strotman NA, Haley M, Benkovics T, Nye J, Xu Z, Tan Y, Ayers S, Gao Q, Kiau S.

J Org Chem. 2017 May 5;82(9):4958-4963. doi: 10.1021/acs.joc.7b00438. Epub 2017 Apr 19.

PMID: 28406018

 

A Nondestructive Method for Measuring Protein Distribution in Frozen Drug Substance.

Du C, Borwankar A, Singh N, Borys M, Li ZJ.

J Pharm Sci. 2017 May 5. pii: S0022-3549(17)30316-7. doi: 10.1016/j.xphs.2017.04.047. [Epub ahead of print]

PMID: 28483421

 

Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families.

Ngcungcu T, Oti M, Sitek JC, Haukanes BI, Linghu B, Bruccoleri R, Stokowy T, Oakeley EJ, Yang F, Zhu J, Sultan M, Schalkwijk J, van Vlijmen-Willems IMJJ, von der Lippe C, Brunner HG, Ersland KM, Grayson W, Buechmann-Moller S, Sundnes O, Nirmala N, Morgan TM, van Bokhoven H, Steen VM, Hull PR, Szustakowski J, Staedtler F, Zhou H, Fiskerstrand T, Ramsay M.

Am J Hum Genet. 2017 May 4;100(5):737-750. doi: 10.1016/j.ajhg.2017.03.012. Epub 2017 Apr 27.

PMID: 28457472

 

Efficacy and safety of abatacept, a T-cell modulator, in a randomised, double-blind, placebo-controlled, phase III study in psoriatic arthritis.

Mease PJ, Gottlieb AB, van der Heijde D, FitzGerald O, Johnsen A, Nys M, Banerjee S, Gladman DD.

Ann Rheum Dis. 2017 May 4. pii: annrheumdis-2016-210724. doi: 10.1136/annrheumdis-2016-210724. [Epub ahead of print]

PMID: 28473423

 

Strategy for the Quantitation of a Protein Conjugate via Hybrid Immunocapture-Liquid Chromatography with Sequential HRMS and SRM-Based LC-MS/MS Analyses.

Zhao Y, Liu G, Yuan X, Gan J, Peterson JE, Shen JX.

Anal Chem. 2017 May 2;89(9):5144-5151. doi: 10.1021/acs.analchem.7b00926. Epub 2017 Apr 21.

PMID: 28402627

 

Antibody Drug-Target Engagement Measurement in Tissue Using Quantitative Affinity Extraction Liquid Chromatography-Mass Spectrometry: Method Development and Qualification.

Ciccimaro E, Zhu Y, Ostanin D, Suchard S, MacGuire J, Xiao Q, Dongre A, Chimalakonda A, Olah T, Shipkova P.

Anal Chem. 2017 May 2;89(9):5115-5123. doi: 10.1021/acs.analchem.7b00688. Epub 2017 Apr 21.

PMID: 28383906

 

Ultrafiltration behavior of monoclonal antibodies and Fc-fusion proteins: Effects of physical properties.

Baek Y, Singh N, Arunkumar A, Borys M, Li ZJ, Zydney AL.

Biotechnol Bioeng. 2017 May 2. doi: 10.1002/bit.26326. [Epub ahead of print]

PMID: 28464237

 

Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective.

Wong H, Bohnert T, Damian-Iordache V, Gibson C, Hsu CP, Krishnatry AS, Liederer BM, Lin J, Lu Q, Mettetal JT, Mudra DR, Nijsen MJMA, Schroeder P, Schuck E, Suryawanshi S, Trapa P, Tsai A, Wang H, Wu F.

Drug Discov Today. 2017 May 2. pii: S1359-6446(17)30002-8. doi: 10.1016/j.drudis.2017.04.015. [Epub ahead of print]

PMID: 28476536

 

Exploring Canine-Human Differences in Product Performance. Part II: Use of Modeling and Simulation to Explore the Impact of Formulation on Ciprofloxacin In Vivo Absorption and Dissolution in Dogs.

Martinez MN, Mistry B, Lukacova V, Lentz KA, Polli JE, Hoag SW, Dowling T, Kona R, Fahmy RM.

AAPS J. 2017 May;19(3):712-726. doi: 10.1208/s12248-017-0055-y. Epub 2017 Mar 6.

PMID: 28265981

 

Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):882. doi: 10.1208/s12248-017-0061-0. No abstract available.

PMID: 28233243

 

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):787-796. doi: 10.1208/s12248-017-0051-2. Epub 2017 Feb 10. Erratum in: AAPS J. 2017 May;19(3):882.

PMID: 28188574

 

Long-term electrocardiographic safety monitoring in clinical drug development: A report from the Cardiac Safety Research Consortium.

Piccini JP, Clark RL, Kowey PR, Mittal S, Dunnmon P, Stockbridge N, Reiffel JA, Turakhia MP, Ziegler PD, Kleiman RB, Ismat F, Sager P.

Am Heart J. 2017 May;187:156-169. doi: 10.1016/j.ahj.2017.01.012. Epub 2017 Jan 26. Review.

PMID: 28454799

 

A phase 2 safety study of accelerated elotuzumab infusion, over less than 1 h, in combination with lenalidomide and dexamethasone, in patients with multiple myeloma.

Berenson J, Manges R, Badarinath S, Cartmell A, McIntyre K, Lyons R, Harb W, Mohamed H, Nourbakhsh A, Rifkin R.

Am J Hematol. 2017 May;92(5):460-466. doi: 10.1002/ajh.24687. Epub 2017 Mar 22.

PMID: 28213943

 

Safety and Efficacy Outcomes 3 Years After Switching to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients: Results From a Phase 2 Randomized Trial.

Grinyó JM, Del Carmen Rial M, Alberu J, Steinberg SM, Manfro RC, Nainan G, Vincenti F, Jones-Burton C, Kamar N.

Am J Kidney Dis. 2017 May;69(5):587-594. doi: 10.1053/j.ajkd.2016.09.021. Epub 2016 Nov 23.

PMID: 27889299

 

 Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection.

Kim SC, Wakwe W, Higginbotham LB, Mathews DV, Breeden CP, Stephenson AC, Jenkins J, Strobert E, Price K, Price L, Kuhn R, Wang H, Yamniuk A, Suchard S, Farris AB 3rd, Pearson TC, Larsen CP, Ford ML, Suri A, Nadler S, Adams AB.

Am J Transplant. 2017 May;17(5):1182-1192. doi: 10.1111/ajt.14197. Epub 2017 Feb 25.

PMID: 28097811

 

Apixaban Versus Warfarin for Mechanical Heart Valve Thromboprophylaxis in a Swine Aortic Heterotopic Valve Model.

Lester PA, Coleman DM, Diaz JA, Jackson TO, Hawley AE, Mathues AR, Grant BT, Knabb RM, Ramacciotti E, Frost CE, Song Y, Wakefield TW, Myers DD Jr.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):942-948. doi: 10.1161/ATVBAHA.116.308649. Epub 2017 Feb 23.

PMID: 28232327

 

Treatment Design and Rationale for a Randomized Trial of Cisplatin and Etoposide Plus Thoracic Radiotherapy Followed by Nivolumab or Placebo for Locally Advanced Non-Small-Cell Lung Cancer (RTOG 3505).

Gerber DE, Urbanic JJ, Langer C, Hu C, Chang IF, Lu B, Movsas B, Jeraj R, Curran WJ, Bradley JD.

Clin Lung Cancer. 2017 May;18(3):333-339. doi: 10.1016/j.cllc.2016.10.009. Epub 2016 Oct 26.

PMID: 27923550

 

Population Pharmacokinetics, Pharmacodynamics, and Exploratory Exposure-Response Analyses of Apixaban in Subjects Treated for Venous Thromboembolism.

Byon W, Sweeney K, Frost C, Boyd RA.

CPT Pharmacometrics Syst Pharmacol. 2017 May;6(5):340-349. doi: 10.1002/psp4.12184.

PMID: 28547774

 

Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects.

Theunissen PT, Beken S, Beyer B, Breslin WJ, Cappon GD, Chen CL, Chmielewski G, de Schaepdrijver L, Enright B, Foreman JE, Harrouk W, Hew KW, Hoberman AM, Y Hui J, Knudsen TB, Laffan SB, Makris SL, Martin M, McNerney ME, Siezen CL, Stanislaus DJ, Stewart J, Thompson KE, Tornesi B, Van der Laan JW, Weinbauer GF, Wood S, Piersma AH.

Crit Rev Toxicol. 2017 May;47(5):402-414. doi: 10.1080/10408444.2016.1224808. Epub 2016 Oct 21.

PMID: 27766926

 

Clinical characteristics, healthcare costs, and resource utilization in hepatitis C vary by genotype.

Goolsby Hunter A, Rosenblatt L, Patel C, Blauer-Peterson C, Anduze-Faris B.

Curr Med Res Opin. 2017 May;33(5):829-836. doi: 10.1080/03007995.2017.1288613. Epub 2017 Feb 10.

PMID: 28128648

 

A survey on IVIVC/IVIVR development in the pharmaceutical industry - Past experience and current perspectives.

Nguyen MA, Flanagan T, Brewster M, Kesisoglou F, Beato S, Biewenga J, Crison J, Holm R, Li R, Mannaert E, McAllister M, Mueller-Zsigmondy M, Muenster U, Ojala K, Page S, Parr A, Rossenu S, Timmins P, Van Peer A, Vermeulen A, Langguth P.

Eur J Pharm Sci. 2017 May 1;102:1-13. doi: 10.1016/j.ejps.2017.02.029. Epub 2017 Feb 21. Review.

PMID: 28235611

 

The Second-Generation Maturation Inhibitor GSK3532795 Maintains Potent Activity Toward HIV Protease Inhibitor-Resistant Clinical Isolates.

Ray N, Li T, Lin Z, Protack T, van Ham PM, Hwang C, Krystal M, Nijhuis M, Lataillade M, Dicker I.

J Acquir Immune Defic Syndr. 2017 May 1;75(1):52-60. doi: 10.1097/QAI.0000000000001304.

PMID: 28234686

 

Management of skin adverse events associated with immune checkpoint inhibitors in patients with melanoma: A nursing perspective.

Thebeau M, Rubin K, Hofmann M, Grimm J, Weinstein A, Choi JN.

J Am Assoc Nurse Pract. 2017 May;29(5):294-303. doi: 10.1002/2327-6924.12458. Epub 2017 Apr 24.

PMID: 28436601

 

Editorial and Review: 28th ASMS Sanibel Conference on Mass Spectrometry-Characterization of Protein Therapeutics by Mass Spectrometry.

Sperry JB, Chen G, Loo JA.

J Am Soc Mass Spectrom. 2017 May;28(5):781-785. doi: 10.1007/s13361-017-1629-8. No abstract available.

PMID: 28374311

 

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.

Huang RY, Iacob RE, Krystek SR, Jin M, Wei H, Tao L, Das TK, Tymiak AA, Engen JR, Chen G.

J Am Soc Mass Spectrom. 2017 May;28(5):795-802. doi: 10.1007/s13361-016-1452-7. Epub 2016 Aug 15.

PMID: 27527097

 

Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+ T Cells.

Xiang B, Baybutt TR, Berman-Booty L, Magee MS, Waldman SA, Alexeev VY, Snook AE.

J Immunol. 2017 May 1;198(9):3507-3514. doi: 10.4049/jimmunol.1502672. Epub 2017 Mar 24.

PMID: 28341670

 

Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics.

Bandyopadhyay AA, Khetan A, Malmberg LH, Zhou W, Hu WS.

J Ind Microbiol Biotechnol. 2017 May;44(4-5):785-797. doi: 10.1007/s10295-017-1913-4. Epub 2017 Feb 9. Review.

PMID: 28185098

 

Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial.

Ascierto PA, Del Vecchio M, Robert C, Mackiewicz A, Chiarion-Sileni V, Arance A, Lebbé C, Bastholt L, Hamid O, Rutkowski P, McNeil C, Garbe C, Loquai C, Dreno B, Thomas L, Grob JJ, Liszkay G, Nyakas M, Gutzmer R, Pikiel J, Grange F, Hoeller C, Ferraresi V, Smylie M, Schadendorf D, Mortier L, Svane IM, Hennicken D, Qureshi A, Maio M.

Lancet Oncol. 2017 May;18(5):611-622. doi: 10.1016/S1470-2045(17)30231-0. Epub 2017 Mar 27.

PMID: 28359784

 

The renal elimination of apixaban: the totality of data relating to the renal clearance of apixaban in patients with impaired renal function: response to Hellfritzsch et al.

Byon W, Cirincione B, Di Russo G, LaCreta F, Boyd R.

Pharmacoepidemiol Drug Saf. 2017 May;26(5):603-605. doi: 10.1002/pds.4163. No abstract available.

PMID: 28444852

 

Comparison of cardiovascular risk algorithms in patients with vs without rheumatoid arthritis and the role of C-reactive protein in predicting cardiovascular outcomes in rheumatoid arthritis.

Alemao E, Cawston H, Bourhis F, Al M, Rutten-van Molken M, Liao KP, Solomon DH.

Rheumatology (Oxford). 2017 May 1;56(5):777-786. doi: 10.1093/rheumatology/kew440.

PMID: 28087832

 

The impact of database restriction on pharmacovigilance signal detection of selected cancer therapies.

Hauben M, Hung E, Wood J, Soitkar A, Reshef D.

Ther Adv Drug Saf. 2017 May;8(5):145-156. doi: 10.1177/2042098616685010. Epub 2017 Feb 1.

PMID: 28588760

 

Assessing the Budget Impact and Economic Outcomes of the Introduction of Daclatasvir + Asunaprevir and Sofosbuvir/Ledipasvir for the Treatment of Chronic Hepatitis C Virus Infection in Japan.

Ward T, Webster S, Mishina S, McEwan P, Wygant G, Wang F.

Value Health Reg Issues. 2017 May;12:1-6. doi: 10.1016/j.vhri.2016.10.002. Epub 2016 Dec 24.

PMID: 28648305

 

Deficiency of CCN5/WISP-2-Driven Program in breast cancer Promotes Cancer Epithelial cells to mesenchymal stem cells and Breast Cancer growth.

Das A, Dhar K, Maity G, Sarkar S, Ghosh A, Haque I, Dhar G, Banerjee S, Banerjee SK.

Sci Rep. 2017 Apr 27;7(1):1220. doi: 10.1038/s41598-017-00916-z.

PMID: 28450698

 

Assessing treatment efficacy in the subset of responders in a randomized clinical trial.

Korn EL, Othus M, Chen T, Freidlin B.

Ann Oncol. 2017 Apr 21. doi: 10.1093/annonc/mdx197. [Epub ahead of print]

PMID: 28444115

 

Revisiting a Classic Transformation: A Lossen Rearrangement Initiated by Nitriles and "Pseudo-Catalytic" in Isocyanate.

Strotman NA, Ortiz A, Savage SA, Wilbert CR, Ayers S, Kiau S.

J Org Chem. 2017 Apr 21;82(8):4044-4049. doi: 10.1021/acs.joc.7b00450. Epub 2017 Apr 12.

PMID: 28394130

 

The Role of Minimal Residual Disease Testing in Myeloma Treatment Selection and Drug Development: Current Value and Future Applications.

Anderson KC, Auclair D, Kelloff GJ, Sigman CC, Avet-Loiseau H, Farrell AT, Gormley NJ, Kumar SK, Landgren O, Munshi NC, Cavo M, Davies FE, Di Bacco A, Dickey JS, Gutman SI, Higley HR, Hussein MA, Jessup JM, Kirsch IR, Little RF, Loberg RD, Lohr JG, Mukundan L, Omel JL, Pugh TJ, Reaman GH, Robbins MD, Sasser AK, Valente N, Zamagni E.

Clin Cancer Res. 2017 Apr 20. pii: clincanres.2895.2016. doi: 10.1158/1078-0432.CCR-16-2895. [Epub ahead of print]

PMID: 28428191

 

Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy.

Gay CL, Bosch RJ, Ritz J, Hataye JM, Aga E, Tressler RL, Mason SW, Hwang CK, Grasela DM, Ray N, Cyktor JC, Coffin JM, Acosta EP, Koup RA, Mellors JW, Eron JJ; AIDS Clinical Trials 5326 Study Team.

J Infect Dis. 2017 Apr 18. doi: 10.1093/infdis/jix191. [Epub ahead of print]

PMID: 28431010

 

Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody.

Segal NH, Logan TF, Hodi FS, McDermott D, Melero I, Hamid O, Schmidt H, Robert C, Chiarion-Sileni V, Ascierto PA, Maio M, Urba WJ, Gangadhar TC, Suryawanshi S, Neely J, Jure-Kunkel M, Krishnan S, Kohrt H, Sznol M, Levy R.

Clin Cancer Res. 2017 Apr 15;23(8):1929-1936. doi: 10.1158/1078-0432.CCR-16-1272. Epub 2016 Oct 18.

PMID: 27756788

 

Adenoma Prevalence in Blacks and Whites Having Equal Adherence To Screening Colonoscopy: The National Colonoscopy Study.

Mendelsohn RB, Winawer SJ, Jammula A, Mills G, Jordan P, O'Brien MJ, Close GM, Dorfman M, Church TR, Mandelson MT, Allen J, Feld A, Kauff ND, Morgan GA, Kumar JMR, Serrano V, Bayuga-Miller S, Fischer SE, Kuk D, Zauber AG.

Clin Gastroenterol Hepatol. 2017 Apr 15. pii: S1542-3565(17)30457-3. doi: 10.1016/j.cgh.2017.04.014. [Epub ahead of print] No abstract available.

PMID: 28419856

 

Nivolumab versus everolimus in advanced renal cell carcinoma: Japanese subgroup analysis from the CheckMate 025 study.

Tomita Y, Fukasawa S, Shinohara N, Kitamura H, Oya M, Eto M, Tanabe K, Kimura G, Yonese J, Yao M, Motzer RJ, Uemura H, McHenry MB, Berghorn E, Ozono S.

Jpn J Clin Oncol. 2017 Apr 13:1-8. doi: 10.1093/jjco/hyx049. [Epub ahead of print]

PMID: 28419248

 

Treatment Beyond Progression in Patients with Advanced Renal Cell Carcinoma Treated with Nivolumab in CheckMate 025.

Escudier B, Motzer RJ, Sharma P, Wagstaff J, Plimack ER, Hammers HJ, Donskov F, Gurney H, Sosman JA, Zalewski PG, Harmenberg U, McDermott DF, Choueiri TK, Richardet M, Tomita Y, Ravaud A, Doan J, Zhao H, Hardy H, George S.

Eur Urol. 2017 Apr 12. pii: S0302-2838(17)30265-8. doi: 10.1016/j.eururo.2017.03.037. [Epub ahead of print]

PMID: 28410865

 

Comparative study of therapeutic antibody candidates derived from mini-pool and clonal cell lines.

Fan L, Rizzi G, Bierilo K, Tian J, Yee JC, Russell R, Das TK.

Biotechnol Prog. 2017 Apr 10. doi: 10.1002/btpr.2477. [Epub ahead of print]

PMID: 28393481

 

Asymmetric Synthesis of the Major Metabolite of a Calcitonin Gene-Related Peptide Receptor Antagonist and Mechanism of Epoxide Hydrogenolysis.

Luo G, Chen L, Conway CM, Kostich W, Johnson BM, Ng A, Macor JE, Dubowchik GM.

J Org Chem. 2017 Apr 7;82(7):3710-3720. doi: 10.1021/acs.joc.7b00052. Epub 2017 Mar 28.

PMID: 28306261

 

Transcriptome Alterations in Prefrontal Pyramidal Cells Distinguish Schizophrenia From Bipolar and Major Depressive Disorders.

Arion D, Huo Z, Enwright JF, Corradi JP, Tseng G, Lewis DA.

Biol Psychiatry. 2017 Apr 4. pii: S0006-3223(17)31442-7. doi: 10.1016/j.biopsych.2017.03.018. [Epub ahead of print]

PMID:28476208

 

Hepatitis C Viral Load, Genotype, and Increased Risk of Developing End-stage Renal Disease: REVEAL-HCV Study.

Lai TS, Lee MH, Yang HI, You SL, Lu SN, Wang LY, Yuan Y, L'Italien G, Chien KL, Chen CJ; REVEAL-HCV Study Group.

Hepatology. 2017 Apr 2. doi: 10.1002/hep.29192. [Epub ahead of print]

PMID: 28370058

 

A Fluorescence-Based High-Throughput Coupled Enzymatic Assay for Quantitation of Isoaspartate in Proteins and Peptides.

Puri A, Quan Y, Narang AS, Adams M, Gandhi R, Nashine VC.

AAPS PharmSciTech. 2017 Apr;18(3):803-808. doi: 10.1208/s12249-016-0570-7. Epub 2016 Jun 24.

PMID: 27342117

 

Development, optimization and implementation of a centralized metabolic soft spot assay.

Paiva AA, Klakouski C, Li S, Johnson BM, Shu YZ, Josephs J, Zvyaga T, Zamora I, Shou WZ.

Bioanalysis. 2017 Apr;9(7):541-552. doi: 10.4155/bio-2016-0299. Epub 2017 Mar 24.

PMID: 28339283

 

In vitro and in vivo evaluation of dasatinib and imatinib on physiological parameters of pulmonary arterial hypertension.

Baumgart B, Guha M, Hennan J, Li J, Woicke J, Simic D, Graziano M, Wallis N, Sanderson T, Bunch RT.

Cancer Chemother Pharmacol. 2017 Apr;79(4):711-723. doi: 10.1007/s00280-017-3264-2. Epub 2017 Mar 10.

PMID: 28283735

 

Masterful Antibodies: Checkpoint Blockade.

Lonberg N, Korman AJ.

Cancer Immunol Res. 2017 Apr;5(4):275-281. doi: 10.1158/2326-6066.CIR-17-0057. Review.

PMID: 28373215

 

Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations.

Butler J, Hamo CE, Udelson JE, O'Connor C, Sabbah HN, Metra M, Shah SJ, Kitzman DW, Teerlink JR, Bernstein HS, Brooks G, Depre C, DeSouza MM, Dinh W, Donovan M, Frische-Danielson R, Frost RJ, Garza D, Gohring UM, Hellawell J, Hsia J, Ishihara S, Kay-Mugford P, Koglin J, Kozinn M, Larson CJ, Mayo M, Gan LM, Mugnier P, Mushonga S, Roessig L, Russo C, Salsali A, Satler C, Shi V, Ticho B, van der Laan M, Yancy C, Stockbridge N, Gheorghiade M.

Circ Heart Fail. 2017 Apr;10(4). pii: e003800. doi: 10.1161/CIRCHEARTFAILURE.116.003800.

PMID: 28356300

 

Investigating Transporter-Mediated Drug-Drug Interactions Using a Physiologically Based Pharmacokinetic Model of Rosuvastatin.

Wang Q, Zheng M, Leil T.

CPT Pharmacometrics Syst Pharmacol. 2017 Apr;6(4):228-238. doi: 10.1002/psp4.12168. Epub 2017 Mar 13.

PMID: 28296193

 

The value of open access and a patient centric approach to oral oncolytic utilization in the treatment of Chronic Myelogenous Leukemia: A U.S. perspective.

Das L, Gitlin M, Siegartel LR, Makenbaeva D.

Expert Rev Pharmacoecon Outcomes Res. 2017 Apr;17(2):133-140. doi: 10.1080/14737167.2017.1305892. Epub 2017 Mar 22. Review.

PMID: 28287008

 

Non-major bleeding with apixaban versus warfarin in patients with atrial fibrillation.

Bahit MC, Lopes RD, Wojdyla DM, Held C, Hanna M, Vinereanu D, Hylek EM, Verheugt F, Goto S, Alexander JH, Wallentin L, Granger CB.

Heart. 2017 Apr;103(8):623-628. doi: 10.1136/heartjnl-2016-309901. Epub 2016 Oct 24.

PMID: 27798052

 

Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study.

Goozee R, O'Daly O, Handley R, Reis Marques T, Taylor H, McQueen G, Hubbard K, Pariante C, Mondelli V, Reinders AA, Dazzan P.

Hum Brain Mapp. 2017 Apr;38(4):1833-1845. doi: 10.1002/hbm.23485. Epub 2016 Dec 23.

PMID: 28009070

 

Role of Fc-FcγR interactions in the antitumor activity of therapeutic antibodies.

Barnhart BC, Quigley M.

Immunol Cell Biol. 2017 Apr;95(4):340-346. doi: 10.1038/icb.2016.121. Epub 2016 Dec 15. Review.

PMID: 27974746

 

A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans.

Cuchel M, Raper AC, Conlon DM, Pryma DA, Freifelder RH, Poria R, Cromley D, Li X, Dunbar RL, French B, Qu L, Farver W, Su CC, Lund-Katz S, Baer A, Ruotolo G, Akerblad P, Ryan CS, Xiao L, Kirchgessner TG, Millar JS, Billheimer JT, Rader DJ.

J Lipid Res. 2017 Apr;58(4):752-762. doi: 10.1194/jlr.M075226. Epub 2017 Feb 6.

PMID: 28167703

 

Control Strategies for Drug Product Continuous Direct Compression-State of Control, Product Collection Strategies, and Startup/Shutdown Operations for the Production of Clinical Trial Materials and Commercial Products.

Almaya A, De Belder L, Meyer R, Nagapudi K, Lin HH, Leavesley I, Jayanth J, Bajwa G, DiNunzio J, Tantuccio A, Blackwood D, Abebe A.

J Pharm Sci. 2017 Apr;106(4):930-943. doi: 10.1016/j.xphs.2016.12.014. Epub 2017 Jan 6.

PMID: 28069357

 

Identification of by-products in support of process development of Muraglitazar.

Pathirana C, Rusowicz A, Suda R, Swaminathan S, Palaniswamy V.

Magn Reson Chem. 2017 Apr;55(4):283-288. doi: 10.1002/mrc.4412. Epub 2016 Feb 17. No abstract available.

PMID: 26891263

 

Designer vaccine nanodiscs for personalized cancer immunotherapy.

Kuai R, Ochyl LJ, Bahjat KS, Schwendeman A, Moon JJ.

Nat Mater. 2017 Apr;16(4):489-496. doi: 10.1038/nmat4822. Epub 2016 Dec 26.

PMID: 28024156

 

Interference from Proteins and Surfactants on Particle Size Distributions Measured by Nanoparticle Tracking Analysis (NTA).

Bai K, Barnett GV, Kar SR, Das TK.

Pharm Res. 2017 Apr;34(4):800-808. doi: 10.1007/s11095-017-2109-3. Epub 2017 Feb 2.

PMID: 28155075

 

Generation of a clonal induced pluripotent stem cell (iPSC) line expressing the mutant MECP2 allele from a Rett Syndrome patient fibroblast line.

Hunihan L, Brown J, Cacace A, Fernandes A, Weston A.

Stem Cell Res. 2017 Apr;20:67-69. doi: 10.1016/j.scr.2017.02.017. Epub 2017 Mar 7.

PMID: 28395743

 

Regulatory Forum Opinion Piece*: Use and Utility of Animal Models of Disease for Nonclinical Safety Assessment: A Pharmaceutical Industry Survey.

Morgan SJ, Couch J, Guzzie-Peck P, Keller DA, Kemper R, Otieno MA, Schulingkamp RJ, Jones TW.

Toxicol Pathol. 2017 Apr;45(3):372-380. doi: 10.1177/0192623317701004. Epub 2017 Mar 28.

PMID: 28351296

 

Accounting for Cured Patients in Cost-Effectiveness Analysis.

Othus M, Bansal A, Koepl L, Wagner S, Ramsey S.

Value Health. 2017 Apr;20(4):705-709. doi: 10.1016/j.jval.2016.04.011. Epub 2016 Jun 9.

PMID: 28408015

 

Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products.

Malins LR, deGruyter JN, Robbins KJ, Scola PM, Eastgate MD, Ghadiri MR, Baran PS.

J Am Chem Soc. 2017 Mar 31. doi: 10.1021/jacs.7b01624. [Epub ahead of print]

PMID: 28326777

 

Daclatasvir/Asunaprevir/Beclabuvir (DCV-TRIO), All-Oral, Fixed-Dose Combination for Patients With Chronic HCV Genotype 1.

Kao JH, Yu ML, Peng CY, Heo J, Chu CJ, Chang TT, Lee YJ, Hu TH, Yoon KT, Paik SW, Lim YS, Ahn SH, Isakov V, McPhee F, Hu W, Swenson ES, Yin PD, Treitel M.

J Gastroenterol Hepatol. 2017 Mar 31. doi: 10.1111/jgh.13796. [Epub ahead of print]

PMID: 28370350

 

Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P1) Agonists and Future Perspectives.

Dyckman AJ.

J Med Chem. 2017 Mar 30. doi: 10.1021/acs.jmedchem.6b01575. [Epub ahead of print]

PMID: 28291340

 

Antiviral Activity, Safety, and Exposure-Response relationships of GSK3532795, a Second-Generation HIV-1 Maturation Inhibitor, administered as Monotherapy or in Combination with Atazanavir±Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Trial (AI468002).

Hwang C, Schürmann D, Sobotha C, Boffito M, Sevinsky H, Ray N, Ravindran P, Xiao H, Keicher C, Hüser A, Krystal M, Dicker IB, Grasela D, Lataillade M.

Clin Infect Dis. 2017 Mar 23. doi: 10.1093/cid/cix239. [Epub ahead of print]

PMID: 28369211

 

Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.

Wu YJ, Guernon J, Shi J, Ditta J, Robbins KJ, Rajamani R, Easton A, Newton A, Bourin C, Mosure K, Soars MG, Knox RJ, Matchett M, Pieschl RL, Post-Munson DJ, Wang S, Herrington J, Graef J, Newberry K, Bristow LJ, Meanwell NA, Olson R, Thompson LA, Dzierba C.

J Med Chem. 2017 Mar 23;60(6):2513-2525. doi: 10.1021/acs.jmedchem.6b01918. Epub 2017 Mar 10.

PMID: 28234467

 

Endogenous opioids regulate moment-to-moment neuronal communication and excitability.

Winters BL, Gregoriou GC, Kissiwaa SA, Wells OA, Medagoda DI, Hermes SM, Burford NT, Alt A, Aicher SA, Bagley EE.

Nat Commun. 2017 Mar 22;8:14611. doi: 10.1038/ncomms14611.

PMID: 28327612

 

Extended release of flurbiprofen from tromethamine-buffered HPMC hydrophilic matrix tablets.

Pygall S, Kujawinski S, Timmins P, Melia C.

Pharm Dev Technol. 2017 Mar 16:1-8. doi: 10.1080/10837450.2017.1301470. [Epub ahead of print]

PMID: 28298171

 

A novel reagent significantly improved assay robustness in imaged capillary isoelectric focusing.

Zhang X, Voronov S, Mussa N, Li Z.

Anal Biochem. 2017 Mar 15;521:1-7. doi: 10.1016/j.ab.2016.12.013. Epub 2017 Jan 6.

PMID: 28065577

 

B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Post-Munson DJ, Pieschl RL, Molski TF, Graef JD, Hendricson AW, Knox RJ, McDonald IM, Olson RE, Macor JE, Weed MR, Bristow LJ, Kiss L, Ahlijanian MK, Herrington J.

Eur J Pharmacol. 2017 Mar 15;799:16-25. doi: 10.1016/j.ejphar.2017.01.037. Epub 2017 Jan 26.

PMID: 28132910

 

Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat.

Taskar KS, Mariappan TT, Kurawattimath V, Singh Gautam S, Radhakrishna Mullapudi TV, Sridhar SK, Kallem RR, Marathe P, Mandlekar S.

J Cent Nerv Syst Dis. 2017 Mar 15;9:1179573517693596. doi: 10.1177/1179573517693596. eCollection 2017.

PMID: 28469522

 

Randomized phase 3 study of elotuzumab for relapsed or refractory multiple myeloma: ELOQUENT-2 Japanese patient subanalysis.

Suzuki K, Sunami K, Ohashi K, Iida S, Mori T, Handa H, Matsue K, Miyoshi M, Bleickardt E, Matsumoto M, Taniwaki M.

Blood Cancer J. 2017 Mar 10;7(3):e540. doi: 10.1038/bcj.2017.18. No abstract available.

PMID: 28282035

 

A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer.

Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Batenchuk C, Burns V, Hirsch FR, Wistuba II.

JAMA Oncol. 2017 Mar 9. doi: 10.1001/jamaoncol.2017.0013. [Epub ahead of print]

PMID: 28278348

 

CD6 as a potential target for treating multiple sclerosis.

Li Y, Singer NG, Whitbred J, Bowen MA, Fox DA, Lin F.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2687-2692. doi: 10.1073/pnas.1615253114. Epub 2017 Feb 16.

PMID: 28209777

 

CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma.

Escudier B, Sharma P, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, Castellano D, Gurney H, Donskov F, Peltola K, Wagstaff J, Gauler TC, Ueda T, Zhao H, Waxman IM, Motzer RJ; CheckMate 025 investigators.

Eur Urol. 2017 Mar 3. pii: S0302-2838(17)30099-4. doi: 10.1016/j.eururo.2017.02.010. [Epub ahead of print]

PMID: 28262413

 

The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton's tyrosine kinase.

Dai J, Wang C, Traeger SC, Discenza L, Obermeier MT, Tymiak AA, Zhang Y.

J Chromatogr A. 2017 Mar 3;1487:116-128. doi: 10.1016/j.chroma.2017.01.016. Epub 2017 Jan 6.

PMID: 28131592

 

Nickel-Catalyzed Synthesis of Quinazolinediones.

Beutner GL, Hsiao Y, Razler T, Simmons EM, Wertjes W.

Org Lett. 2017 Mar 3;19(5):1052-1055. doi: 10.1021/acs.orglett.7b00052. Epub 2017 Feb 13.

PMID: 28253632

 

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits.

Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stančáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T, Collins FS, Gargalovic PS, Boehnke M, Laakso M, Mohlke KL, Lusis AJ.

Am J Hum Genet. 2017 Mar 2;100(3):428-443. doi: 10.1016/j.ajhg.2017.01.027.

PMID: 28257690

 

Approaches to Mitigate the Unwanted Immunogenicity of Therapeutic Proteins during Drug Development.

Salazar-Fontana LI, Desai DD, Khan TA, Pillutla RC, Prior S, Ramakrishnan R, Schneider J, Joseph A.

AAPS J. 2017 Mar;19(2):377-385. doi: 10.1208/s12248-016-0030-z. Epub 2017 Jan 12.

PMID: 28083796

 

An Integrated Assessment of the Effects of Immunogenicity on the Pharmacokinetics, Safety, and Efficacy of Elotuzumab.

Passey C, Mora J, Dodge R, Gibiansky L, Sheng J, Roy A, Bello A, Gupta M.

AAPS J. 2017 Mar;19(2):557-567. doi: 10.1208/s12248-016-0033-9. Epub 2017 Jan 9.

PMID: 28070715

 

Use of Spray-Dried Dispersions in Early Pharmaceutical Development: Theoretical and Practical Challenges.

Li J, Patel D, Wang G.

AAPS J. 2017 Mar;19(2):321-333. doi: 10.1208/s12248-016-0017-9. Epub 2016 Nov 28.

PMID: 27896684

 

Population Pharmacokinetics of an Extended-Release Formulation of Exenatide Following Single- and Multiple-Dose Administration.

Cirincione B, Edwards J, Mager DE.

AAPS J. 2017 Mar;19(2):487-496. doi: 10.1208/s12248-016-9975-1. Epub 2016 Nov 28.

PMID: 27896683

 

Anemia is associated with bleeding and mortality, but not stroke, in patients with atrial fibrillation: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.

Westenbrink BD, Alings M, Granger CB, Alexander JH, Lopes RD, Hylek EM, Thomas L, Wojdyla DM, Hanna M, Keltai M, Steg PG, De Caterina R, Wallentin L, van Gilst WH.

Am Heart J. 2017 Mar;185:140-149. doi: 10.1016/j.ahj.2016.12.008. Epub 2016 Dec 22.

PMID: 28267467

 

Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR.

Iwuagwu C, King D, McDonald IM, Cook J, Zusi FC, Hill MD, Mate RA, Fang H, Knox R, Gallagher L, Post-Munson Amy Easton D, Miller R, Benitex Y, Siuciak J, Lodge N, Zaczek R, Morgan D, Bristow L, Macor JE, Olson RE.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1261-1266. doi: 10.1016/j.bmcl.2017.01.058. Epub 2017 Jan 20.

PMID: 28169167

 

Systematic interpolation method predicts protein chromatographic elution with salt gradients, pH gradients and combined salt/pH gradients.

Creasy A, Barker G, Carta G.

Biotechnol J. 2017 Mar;12(3). doi: 10.1002/biot.201600636. Epub 2017 Jan 24.

PMID: 27992113

 

Characterization of TAP Ambr 250 disposable bioreactors, as a reliable scale-down model for biologics process development.

Xu P, Clark C, Ryder T, Sparks C, Zhou J, Wang M, Russell R, Scott C.

Biotechnol Prog. 2017 Mar;33(2):478-489. doi: 10.1002/btpr.2417. Epub 2017 Feb 6.

PMID: 27977912

 

Population pharmacokinetics of exenatide.

Cirincione B, Mager DE.

Br J Clin Pharmacol. 2017 Mar;83(3):517-526. doi: 10.1111/bcp.13135. Epub 2016 Nov 16.

PMID: 27650681

 

Asunaprevir: An HCV Protease Inhibitor With Preferential Liver Distribution.

Eley T, Garimella T, Li W, Bertz RJ.

Clin Pharmacol Drug Dev. 2017 Mar;6(2):195-200. doi: 10.1002/cpdd.315.

PMID: 28263460

 

Harmonizing Global Biospecimen Consent Practices to Advance Translational Research: A Call to Action.

Warner AW, Moore H, Reinhard D, Ball LA, Knoppers BM.

Clin Pharmacol Ther. 2017 Mar;101(3):317-319. doi: 10.1002/cpt.461. Epub 2016 Sep 28.

PMID: 27558027

 

Budget impact analysis of the simplification to atazanavir + ritonavir + lamivudine dual therapy of HIV-positive patients receiving atazanavir-based triple therapies in Italy starting from data of the Atlas-M trial.

Restelli U, Fabbiani M, Di Giambenedetto S, Nappi C, Croce D.

Clinicoecon Outcomes Res. 2017 Mar 1;9:173-179. doi: 10.2147/CEOR.S127097. eCollection 2017. Erratum in: Clinicoecon Outcomes Res. 2017 Apr 19;9:231.

PMID: 28280375

 

Readmission Risk in Chronic Obstructive Pulmonary Disease Patients: Comparative Study of Nebulized β2-Agonists.

Bollu V, Guérin A, Gauthier G, Hiscock R, Wu EQ.

Drugs Real World Outcomes. 2017 Mar;4(1):33-41. doi: 10.1007/s40801-016-0097-y.

PMID: 27864792

 

Single jugular vein cannulated rats may not be suitable for intravenous pharmacokinetic screening of high logP compounds.

Gaud N, Kumar A, Matta M, Kole P, Sridhar S, Mandlekar S, Holenarsipur VK.

Eur J Pharm Sci. 2017 Mar 1;99:272-278. doi: 10.1016/j.ejps.2016.12.025. Epub 2016 Dec 26.

PMID: 28034694

 

Efficacy and safety of daclatasvir plus pegylated-interferon alfa 2a and ribavirin in previously untreated HCV subjects coinfected with HIV and HCV genotype-1: a Phase III, open-label study.

Sulkowski MS, Fessel WJ, Lazzarin A, Berenguer J, Zakharova N, Cheinquer H, Côté P, Dieterich D, Gadano A, Matthews G, Molina JM, Moreno C, Pineda JA, Pulido F, Rivero A, Rockstroh J, Hernandez D, McPhee F, Eley T, Liu Z, Mendez P, Hughes E, Noviello S, Ackerman P.

Hepatol Int. 2017 Mar;11(2):188-198. doi: 10.1007/s12072-017-9788-z. Epub 2017 Feb 16.

PMID: 28210927

 

Elotuzumab with lenalidomide and dexamethasone for Japanese patients with relapsed/refractory multiple myeloma: phase 1 study.

Iida S, Nagai H, Kinoshita G, Miyoshi M, Robbins M, Pandya D, Bleickardt E, Chou T.

Int J Hematol. 2017 Mar;105(3):326-334. doi: 10.1007/s12185-016-2138-4. Epub 2016 Nov 15.

PMID: 27848182

 

Safety Profile of Nivolumab Monotherapy: A Pooled Analysis of Patients With Advanced Melanoma.

Weber JS, Hodi FS, Wolchok JD, Topalian SL, Schadendorf D, Larkin J, Sznol M, Long GV, Li H, Waxman IM, Jiang J, Robert C.

J Clin Oncol. 2017 Mar;35(7):785-792. doi: 10.1200/JCO.2015.66.1389. Epub 2016 Nov 14.

PMID: 28068177

 

Evaluation of Immunogenicity of Nivolumab Monotherapy and Its Clinical Relevance in Patients With Metastatic Solid Tumors.

Agrawal S, Statkevich P, Bajaj G, Feng Y, Saeger S, Desai DD, Park JS, Waxman IM, Roy A, Gupta M.

J Clin Pharmacol. 2017 Mar;57(3):394-400. doi: 10.1002/jcph.818. Epub 2016 Sep 27.

PMID: 27557786

 

Daclatasvir/asunaprevir/beclabuvir fixed-dose combination in Japanese patients with HCV genotype 1 infection.

Toyota J, Karino Y, Suzuki F, Ikeda F, Ido A, Tanaka K, Takaguchi K, Naganuma A, Tomita E, Chayama K, Fujiyama S, Inada Y, Yoshiji H, Watanabe H, Ishikawa H, Hu W, McPhee F, Linaberry M, Yin PD, Swenson ES, Kumada H.

J Gastroenterol. 2017 Mar;52(3):385-395. doi: 10.1007/s00535-016-1245-6. Epub 2016 Aug 9.

PMID: 27502287

 

Safety and Efficacy of Pegylated Interferon Lambda, Ribavirin, and Daclatasvir in HCV and HIV-Coinfected Patients.

Nelson M, Rubio R, Lazzarin A, Romanova S, Luetkemeyer A, Conway B, Molina JM, Xu D, Srinivasan S, Portsmouth S.

J Interferon Cytokine Res. 2017 Mar;37(3):103-111. doi: 10.1089/jir.2016.0082. Epub 2017 Feb 17.

PMID: 28282271

 

Synthesis of unlabelled and stable-isotope-labelled glucuronide metabolites of dapagliflozin and synthesis of stable-isotope-labelled dapagliflozin.

Cao K, Brailsford JA, Yao M, Caceres-Cortes J, Espina R, Bonacorsi SJ Jr.

J Labelled Comp Radiopharm. 2017 Mar;60(3):150-159. doi: 10.1002/jlcr.3484. Epub 2017 Feb 1.

PMID: 27868223

 

Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation.

Takazawa T, Choudhury P, Tong CK, Conway CM, Scherrer G, Flood PD, Mukai J, MacDermott AB.

J Neurosci. 2017 Mar 1;37(9):2336-2348. doi: 10.1523/JNEUROSCI.2354-16.2017. Epub 2017 Jan 27.

PMID: 28130358

 

Health-related quality of life with adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): secondary outcomes of a multinational, randomised, double-blind, phase 3 trial.

Coens C, Suciu S, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, Lebbé C, Ferraresi V, Smylie M, Weber JS, Maio M, Bottomley A, Kotapati S, de Pril V, Testori A, Eggermont AM.

Lancet Oncol. 2017 Mar;18(3):393-403. doi: 10.1016/S1470-2045(17)30015-3. Epub 2017 Feb 3.

PMID: 28162999

 

Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial.

Sharma P, Retz M, Siefker-Radtke A, Baron A, Necchi A, Bedke J, Plimack ER, Vaena D, Grimm MO, Bracarda S, Arranz JÁ, Pal S, Ohyama C, Saci A, Qu X, Lambert A, Krishnan S, Azrilevich A, Galsky MD.

Lancet Oncol. 2017 Mar;18(3):312-322. doi: 10.1016/S1470-2045(17)30065-7. Epub 2017 Jan 26.

PMID: 28131785

 

Advances in analytical methodologies to guide bioprocess engineering for bio-therapeutics.

Saldova R, Kilcoyne M, Stöckmann H, Millán Martín S, Lewis AM, Tuite CM, Gerlach JQ, Le Berre M, Borys MC, Li ZJ, Abu-Absi NR, Leister K, Joshi L, Rudd PM.

Methods. 2017 Mar 1;116:63-83. doi: 10.1016/j.ymeth.2016.11.002. Epub 2016 Nov 8.

PMID: 27832969

 

Novel platens to measure the hardness of a pentagonal shaped tablet.

Malladi J, Sidik K, Wu S, McCann R, Dougherty J, Parab P, Carragher T.

Pharm Dev Technol. 2017 Mar;22(2):246-255. doi: 10.1080/10837450.2016.1219370. Epub 2016 Oct 4.

PMID: 27607150

 

Effects of Histidine and Sucrose on the Biophysical Properties of a Monoclonal Antibody.

Baek Y, Singh N, Arunkumar A, Zydney AL.

Pharm Res. 2017 Mar;34(3):629-639. doi: 10.1007/s11095-016-2092-0. Epub 2016 Dec 29.

PMID: 28035628

 

Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption.

Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ.

Pharm Res. 2017 Mar;34(3):619-628. doi: 10.1007/s11095-016-2090-2. Epub 2016 Dec 27.

PMID: 28028768

 

Real-world experience with daclatasvir plus sofosbuvir ± ribavirin for post-liver transplant HCV recurrence and severe liver disease.

Herzer K, Welzel TM, Spengler U, Hinrichsen H, Klinker H, Berg T, Ferenci P, Peck-Radosavljevic M, Inderson A, Zhao Y, Jimenez-Exposito MJ, Zeuzem S.

Transpl Int. 2017 Mar;30(3):243-255. doi: 10.1111/tri.12910.

PMID: 28012215

 

The effect of apixaban on the pharmacokinetics of digoxin and atenolol in healthy subjects.

Frost C, Song Y, Yu Z, Wang J, Lee LS, Schuster A, Pollack A, LaCreta F.

Clin Pharmacol. 2017 Feb 23;9:19-28. doi: 10.2147/CPAA.S115687. eCollection 2017.

PMID: 28260951

 

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.

Jurica EA, Wu X, Williams KN, Hernandez AS, Nirschl DS, Rampulla RA, Mathur A, Zhou M, Cao G, Xie C, Jacob B, Cai H, Wang T, Murphy BJ, Liu H, Xu C, Kunselman LK, Hicks MB, Sun Q, Schnur DM, Sitkoff DF, Dierks EA, Apedo A, Moore DB, Foster KA, Cvijic ME, Panemangalore R, Flynn NA, Maxwell BD, Hong Y, Tian Y, Wilkes JJ, Zinker BA, Whaley JM, Barrish JC, Robl JA, Ewing WR, Ellsworth BA.

J Med Chem. 2017 Feb 23;60(4):1417-1431. doi: 10.1021/acs.jmedchem.6b01559. Epub 2017 Feb 9.

PMID: 28112924

 

Eldelumab [anti-interferon-γ-inducible protein-10 antibody] Induction Therapy for Active Crohn's Disease: a Randomised, Double-blind, Placebo-controlled Phase IIa Study.

Sandborn WJ, Rutgeerts P, Colombel JF, Ghosh S, Petryka R, Sands BE, Mitra P, Luo A.

J Crohns Colitis. 2017 Feb 22. doi: 10.1093/ecco-jcc/jjx005. [Epub ahead of print]

PMID: 28333187

 

Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.

Li J, Wei H, Krystek SR Jr, Bond D, Brender TM, Cohen D, Feiner J, Hamacher N, Harshman J, Huang RY, Julien SH, Lin Z, Moore K, Mueller L, Noriega C, Sejwal P, Sheppard P, Stevens B, Chen G, Tymiak AA, Gross ML, Schneeweis LA.

Anal Chem. 2017 Feb 21;89(4):2250-2258. doi: 10.1021/acs.analchem.6b03058. Epub 2017 Feb 9.

PMID: 28193005

 

The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.

Nishida Y, Maeda A, Kim MJ, Cao L, Kubota Y, Ishizawa J, AlRawi A, Kato Y, Iwama A, Fujisawa M, Matsue K, Weetall M, Dumble M, Andreeff M, Davis TW, Branstrom A, Kimura S, Kojima K.

Blood Cancer J. 2017 Feb 17;7(2):e527. doi: 10.1038/bcj.2017.8.

PMID: 28211885

 

Catalytic intermolecular hydroaminations of unactivated olefins with secondary alkyl amines.

Musacchio AJ, Lainhart BC, Zhang X, Naguib SG, Sherwood TC, Knowles RR.

Science. 2017 Feb 17;355(6326):727-730. doi: 10.1126/science.aal3010.

PMID: 28209894

 

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.

Qin LY, Ruan Z, Cherney RJ, Dhar TG, Neels J, Weigelt CA, Sack JS, Srivastava AS, Cornelius LA, Tino JA, Stefanski K, Gu X, Xie J, Susulic V, Yang X, Yarde-Chinn M, Skala S, Bosnius R, Goldstein C, Davies P, Ruepp S, Salter-Cid L, Bhide RS, Poss MA.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):855-861. doi: 10.1016/j.bmcl.2017.01.016. Epub 2017 Jan 10.

PMID: 28108251

 

Functionalized triazines as potent HCV entry inhibitors.

Mull ES, Sun LQ, Zhao Q, Eggers B, Pokornowski K, Zhai G, Rajamani R, Jenkins S, Kramer M, Wang YK, Fang H, Tenney D, Baldick CJ, Cockett MI, Meanwell NA, Scola PM.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):1089-1093. doi: 10.1016/j.bmcl.2016.12.038. Epub 2016 Dec 18.

PMID: 28089701

 

Effective Combination of Innate and Adaptive Immunotherapeutic Approaches in a Mouse Melanoma Model.

Rakhmilevich AL, Felder M, Lever L, Slowinski J, Rasmussen K, Hoefges A, Van De Voort TJ, Loibner H, Korman AJ, Gillies SD, Sondel PM.

J Immunol. 2017 Feb 15;198(4):1575-1584. doi: 10.4049/jimmunol.1601255. Epub 2017 Jan 6.

PMID: 28062694

 

Major Bleeding Complications and Persistence With Oral Anticoagulation in Non-Valvular Atrial Fibrillation: Contemporary Findings in Real-Life Danish Patients.

Lamberts M, Staerk L, Olesen JB, Fosbøl EL, Hansen ML, Harboe L, Lefevre C, Evans D, Gislason GH.

J Am Heart Assoc. 2017 Feb 14;6(2). pii: e004517. doi: 10.1161/JAHA.116.004517.

PMID: 28196815

 

Baseline autoantibodies preferentially impact abatacept efficacy in patients with rheumatoid arthritis who are biologic naïve: 6-month results from a real-world, international, prospective study.

Alten R, Nüßlein HG, Mariette X, Galeazzi M, Lorenz HM, Cantagrel A, Chartier M, Poncet C, Rauch C, Le Bars M.

RMD Open. 2017 Feb 13;3(1):e000345. doi: 10.1136/rmdopen-2016-000345. eCollection 2017.

PMID: 28243468

 

BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.

King D, Iwuagwu C, Cook J, McDonald IM, Mate R, Zusi FC, Hill MD, Fang H, Zhao R, Wang B, Easton AE, Miller R, Post-Munson D, Knox RJ, Gallagher L, Westphal R, Molski T, Fan J, Clarke W, Benitex Y, Lentz KA, Denton R, Morgan D, Zaczek R, Lodge NJ, Bristow LJ, Macor JE, Olson RE.

ACS Med Chem Lett. 2017 Feb 8;8(3):366-371. doi: 10.1021/acsmedchemlett.7b00032. eCollection 2017 Mar 9.

PMID: 28337332

A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation.

Tang P, Xu J, Oliveira CL, Li ZJ, Liu S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):564-571. doi: 10.1080/14756366.2016.1275606.

PMID: 28114833

 

Single jugular vein cannulated rats may not be suitable for intravenous pharmacokinetic screening of high logP compounds.

Gaud N, Kumar A, Matta M, Kole P, Sridhar S, Mandlekar S, Holenarsipur VK.

Eur J Pharm Sci. 2017 Mar 1;99:272-278. doi: 10.1016/j.ejps.2016.12.025.

PMID: 28034694

 

Effects of Histidine and Sucrose on the Biophysical Properties of a Monoclonal Antibody.

Baek Y, Singh N, Arunkumar A, Zydney AL.

Pharm Res. 2017 Mar;34(3):629-639. doi: 10.1007/s11095-016-2092-0.

PMID: 28035628

 

Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption.

Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ.

Pharm Res. 2017 Mar;34(3):619-628. doi: 10.1007/s11095-016-2090-2.

PMID: 28028768

 

Characterization of Phase Separation Propensity for Amorphous Spray Dried Dispersions.

McNamara D, Yin S, Pan D, Crull G, Timmins P, Vig B.

Mol Pharm. 2017 Feb 6;14(2):377-385. doi: 10.1021/acs.molpharmaceut.6b00722.

PMID: 28068097

 

Formation of α-chiral centers by asymmetric β-C(sp3)-H arylation, alkenylation, and alkynylation.

Wu QF, Shen PX, He J, Wang XB, Zhang F, Shao Q, Zhu RY, Mapelli C, Qiao JX, Poss MA, Yu JQ.

Science. 2017 Feb 3;355(6324):499-503. doi: 10.1126/science.aal5175.

PMID: 28154075

 

Health-related quality of life with adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): secondary outcomes of a multinational, randomised, double-blind, phase 3 trial.

Coens C, Suciu S, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, Lebbé C, Ferraresi V, Smylie M, Weber JS, Maio M, Bottomley A, Kotapati S, de Pril V, Testori A, Eggermont AM.

Lancet Oncol. 2017 Feb 2. pii: S1470-2045(17)30015-3. doi: 10.1016/S1470-2045(17)30015-3. [Epub ahead of print]

PMID: 28162999

 

Interference from Proteins and Surfactants on Particle Size Distributions Measured by Nanoparticle Tracking Analysis (NTA).

Bai K, Barnett GV, Kar SR, Das TK.

Pharm Res. 2017 Feb 2. doi: 10.1007/s11095-017-2109-3. [Epub ahead of print]

PMID: 28155075

 

A Rational Analysis of Uniformity Risk for Agglomerated Drug Substance Using NIR Chemical Imaging.

Scherholz ML, Wan B, McGeorge G.

AAPS PharmSciTech. 2017 Feb;18(2):432-440. doi: 10.1208/s12249-016-0523-1.

PMID: 27052406

 

Tolerability of central nervous system symptoms among HIV-1 infected efavirenz users: analysis of patient electronic medical record data.

Rosenblatt L, Broder MS, Bentley TG, Chang E, Reddy SR, Papoyan E, Myers J.

AIDS Care. 2017 Feb 1:1-7. doi: 10.1080/09540121.2017.1280123. [Epub ahead of print]

PMID: 28147708

 

Ligand-Enabled β-C-H Arylation of α-Amino Acids Without Installing Exogenous Directing Groups.

Chen G, Zhuang Z, Li GC, Saint-Denis TG, Hsiao Y, Joe CL, Yu JQ.

Angew Chem Int Ed Engl. 2017 Feb 1;56(6):1506-1509. doi: 10.1002/anie.201610580.

PMID: 28052530

 

Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.

Wang AX, Chen J, Zhao Q, Sun LQ, Friborg J, Yu F, Hernandez D, Good AC, Klei HE, Rajamani R, Mosure K, Knipe JO, Li D, Zhu J, Levesque PC, McPhee F, Meanwell NA, Scola PM.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):590-596. doi: 10.1016/j.bmcl.2016.12.013.

PMID: 28011221

 

Identification and optimization of a novel series of indoleamine 2,3-dioxygenase inhibitors.

Markwalder JA, Seitz SP, Blat Y, Elkin L, Hunt JT, Pabalan JG, Jure-Kunkel MN, Vite GD, Covello K.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):582-585. doi: 10.1016/j.bmcl.2016.12.015.

PMID: 28003141

 

Development of spiroguanidine-derived α7 neuronal nicotinic receptor partial agonists.

Hill MD, Fang H, Digavalli SV, Healy FL, Gallagher L, Post-Munson D, Chen P, Natale J, Benitex Y, Morgan D, Lodge N, Bristow L, Macor JE, Olson RE.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):578-581. doi: 10.1016/j.bmcl.2016.12.014.

PMID: 27993517

 

Use of a cocktail probe to assess potential drug interactions with cytochrome P450 after administration of belatacept, a costimulatory immunomodulator.

Williams D, Tao X, Zhu L, Stonier M, Lutz JD, Masson E, Zhang S, Ganguly B, Tzogas Z, Lubin S, Murthy B.

Br J Clin Pharmacol. 2017 Feb;83(2):370-380. doi: 10.1111/bcp.13097.

PMID: 27552251

 

Dasatinib Changes Immune Cell Profiles Concomitant with Reduced Tumor Growth in Several Murine Solid Tumor Models.

Hekim C, Ilander M, Yan J, Michaud E, Smykla R, Vähä-Koskela M, Savola P, Tähtinen S, Saikko L, Hemminki A, Kovanen PE, Porkka K, Lee FY, Mustjoki S.

Cancer Immunol Res. 2017 Feb;5(2):157-169. doi: 10.1158/2326-6066.CIR-16-0061-T.

PMID: 28073775

 

Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape.

Noguchi T, Ward JP, Gubin MM, Arthur CD, Lee SH, Hundal J, Selby MJ, Graziano RF, Mardis ER, Korman AJ, Schreiber RD.

Cancer Immunol Res. 2017 Feb;5(2):106-117. doi: 10.1158/2326-6066.CIR-16-0391.

PMID: 28073774

 

Oncology Nurse Navigation: Results of the 2016 Role Delineation Study.

Lubejko BG, Bellfield S, Kahn E, Lee C, Peterson N, Rose T, Murphy CM, McCorkle M.

Clin J Oncol Nurs. 2017 Feb 1;21(1):43-50. doi: 10.1188/17.CJON.43-50.

PMID: 28107327

 

Organic Anion Transporter 2: An Enigmatic Human Solute Carrier.

Shen H, Lai Y, Rodrigues AD.

Drug Metab Dispos. 2017 Feb;45(2):228-236. doi: 10.1124/dmd.116.072264.

PMID: 27872146

 

A clinician's guide to the cost and health benefits of hepatitis C cure assessed from the individual patient perspective.

McEwan P, Selvapatt N, Brown A, Thursz M, Bennett H, Webster S, Kalsekar A, Yuan Y, Brenner M, Gordon J.

Eur J Gastroenterol Hepatol. 2017 Feb;29(2):208-214. doi: 10.1097/MEG.0000000000000773.

PMID: 27832039

 

CYP2C19 Genotype-Dependent Pharmacokinetic Drug Interaction Between Voriconazole and Ritonavir-Boosted Atazanavir in Healthy Subjects.

Zhu L, Brüggemann RJ, Uy J, Colbers A, Hruska MW, Chung E, Sims K, Vakkalagadda B, Xu X, van Schaik RH, Burger DM, Bertz RJ.

J Clin Pharmacol. 2017 Feb;57(2):235-246. doi: 10.1002/jcph.798.

PMID: 27432796

 

Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti-CD28 Domain Antibody Antagonist in Healthy Subjects.

Shi R, Honczarenko M, Zhang S, Fleener C, Mora J, Lee SK, Wang R, Liu X, Shevell DE, Yang Z, Wang H, Murthy B.

J Clin Pharmacol. 2017 Feb;57(2):161-172. doi: 10.1002/jcph.791.

PMID: 27402064

 

Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity.

Dudhgaonkar S, Ranade S, Nagar J, Subramani S, Prasad DS, Karunanithi P, Srivastava R, Venkatesh K, Selvam S, Krishnamurthy P, Mariappan TT, Saxena A, Fan L, Stetsko DK, Holloway DA, Li X, Zhu J, Yang WP, Ruepp S, Nair S, Santella J, Duncia J, Hynes J, McIntyre KW, Carman JA.

J Immunol. 2017 Feb 1;198(3):1308-1319. doi: 10.4049/jimmunol.1600583.

PMID: 28003376

 

Development and Optimization of a Wet Granulation Process at Elevated Temperature for a Poorly Compactible Drug Using Twin Screw Extruder for Continuous Manufacturing.

Meena AK, Desai D, Serajuddin AT.

J Pharm Sci. 2017 Feb;106(2):589-600. doi: 10.1016/j.xphs.2016.10.020.

PMID: 27890244

 

Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1.

Shen H, Li W, Humphreys WG, Lai Y.

J Pharmacol Exp Ther. 2017 Feb;360(2):341-342. doi: 10.1124/jpet.116.238337. No abstract available.

PMID: 28104831

 

PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project.

Hirsch FR, McElhinny A, Stanforth D, Ranger-Moore J, Jansson M, Kulangara K, Richardson W, Towne P, Hanks D, Vennapusa B, Mistry A, Kalamegham R, Averbuch S, Novotny J, Rubin E, Emancipator K, McCaffery I, Williams JA, Walker J, Longshore J, Tsao MS, Kerr KM.

J Thorac Oncol. 2017 Feb;12(2):208-222. doi: 10.1016/j.jtho.2016.11.2228.

PMID: 27913228

 

Chronic hepatitis C virus infection and the risk for diabetes: a community-based prospective study.

Lin YJ, Shaw TG, Yang HI, Lu SN, Jen CL, Wang LY, Wong KH, Chan SY, Yuan Y, L'Italien G, Chen CJ, Lee MH; R.E.V.E.A.L.-HCV Study Group..

Liver Int. 2017 Feb;37(2):179-186. doi: 10.1111/liv.13194.

PMID: 27363856

 

An Analytical Comparison of Dako 28-8 PharmDx Assay and an E1L3N Laboratory-Developed Test in the Immunohistochemical Detection of Programmed Death-Ligand 1.

Cogswell J, Inzunza HD, Wu Q, Feder JN, Mintier G, Novotny J, Cardona DM.

Mol Diagn Ther. 2017 Feb;21(1):85-93. doi: 10.1007/s40291-016-0237-9.

PMID: 27667773

 

Risk of hepatitis C virus related hepatocellular carcinoma between subjects with spontaneous and treatment-induced viral clearance.

Huang CF, Yeh ML, Huang CI, Lin YJ, Tsai PC, Lin ZY, Chan SY, Chen SC, Yang HI, Huang JF, Lu SN, Dai CY, Jen CL, Yuan Y, L'Italien G, Wang LY, Lee MH, Yu ML, Chuang WL, Chen CJ.

Oncotarget. 2017 Feb 1. doi: 10.18632/oncotarget.14937. [Epub ahead of print]

PMID: 28159934

 

Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1).

Otieno MA, Bhaskaran V, Janovitz E, Callejas Y, Foster WB, Washburn W, Megill JR, Lehman-McKeeman L, Gemzik B.

Toxicol Sci. 2017 Feb;155(2):379-388. doi: 10.1093/toxsci/kfw216.

PMID: 28025230

 

From the Cover: Investigative Nonclinical Cardiovascular Safety and Toxicology Studies with BMS-986094, an NS5b RNA-Dependent RNA Polymerase Inhibitor.

Gill M, Horn K, Hennan J, White R, Bounous D, Clark S, Megill JR, Janovitz E, Davies M, Sanderson T, Graziano M.

Toxicol Sci. 2017 Feb;155(2):348-362. doi: 10.1093/toxsci/kfw211.

PMID: 27864544

 

Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker.

Corte JR, Fang T, Osuna H, Pinto DJ, Rossi KA, Myers JE Jr, Sheriff S, Lou Z, Zheng JJ, Harper TW, Bozarth JM, Wu Y, Luettgen JM, Seiffert DA, Decicco CP, Wexler RR, Quan ML.

J Med Chem. 2017 Jan 31. doi: 10.1021/acs.jmedchem.6b01460. [Epub ahead of print]

PMID: 28085275

 

Cost-effectiveness Analysis for Apixaban in the Acute Treatment and Prevention of Venous Thromboembolism in the Netherlands.

de Jong LA, Dvortsin E, Janssen KJ, Postma MJ.

Clin Ther. 2017 Jan 27. pii: S0149-2918(16)30925-0. doi: 10.1016/j.clinthera.2016.12.012. [Epub ahead of print]

PMID: 28139289

 

Clinical characteristics, healthcare costs, and resource utilization in hepatitis C vary by genotype.

Goolsby Hunter A, Rosenblatt L, Patel C, Blauer-Peterson C, Anduze-Faris B.

Curr Med Res Opin. 2017 Jan 27:1-24. doi: 10.1080/03007995.2017.1288613. [Epub ahead of print]

PMID: 28128648

 

Inhibition mediated by glycinergic and GABAergic receptors on excitatory neurons in mouse superficial dorsal horn is location specific but modified by inflammation.

Takazawa T, Choudhury P, Tong CK, Conway CM, Scherrer G, Flood PD, Mukai J, MacDermott AB.

J Neurosci. 2017 Jan 27. pii: 2354-16. doi: 10.1523/JNEUROSCI.2354-16.2017. [Epub ahead of print]

PMID: 28130358

 

Ligand and Target Discovery by Fragment-Based Screening in Human Cells.

Parker CG, Galmozzi A, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF.

Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029.

PMID: 28111073

 

B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Post-Munson DJ, Pieschl RL, Molski TF, Graef JD, Hendricson AW, Knox RJ, McDonald IM, Olson RE, Macor JE, Weed MR, Bristow LJ, Kiss L, Ahlijanian MK, Herrington J.

Eur J Pharmacol. 2017 Jan 26. pii: S0014-2999(17)30046-8. doi: 10.1016/j.ejphar.2017.01.037. [Epub ahead of print]

PMID: 28132910

 

Current practice and perspectives in CRO oversight based on a survey performed among members of the German Association of Research-Based Pharmaceutical Companies (vfa).

Hennig M, Hundt F, Busta S, Mikus S, Sanden PH, Sörgel A, Ruppert T.

Ger Med Sci. 2017 Jan 26;15:Doc02. doi: 10.3205/000243.

PMID: 28163667

 

Objective Response by mRECIST as a Predictor and Potential Surrogate End Point of Overall Survival in Advanced HCC.

Lencioni R, Montal R, Torres F, Park JW, Decaens T, Raoul JL, Kudo M, Chang C, Ríos J, Boige V, Assenat E, Kang YK, Lim HY, Walters I, Llovet JM.

J Hepatol. 2017 Jan 25. pii: S0168-8278(17)30016-8. doi: 10.1016/j.jhep.2017.01.012. [Epub ahead of print]

PMID: 28131794

 

Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial.

Sharma P, Retz M, Siefker-Radtke A, Baron A, Necchi A, Bedke J, Plimack ER, Vaena D, Grimm MO, Bracarda S, Arranz JÁ, Pal S, Ohyama C, Saci A, Qu X, Lambert A, Krishnan S, Azrilevich A, Galsky MD.

Lancet Oncol. 2017 Jan 25. pii: S1470-2045(17)30065-7. doi: 10.1016/S1470-2045(17)30065-7. [Epub ahead of print]

PMID: 28131785

 

Cost-effectiveness of apixaban versus low molecular weight heparin/vitamin k antagonist for the treatment of venous thromboembolism and the prevention of recurrences.

Lanitis T, Leipold R, Hamilton M, Rublee D, Quon P, Browne C, Cohen AT.

BMC Health Serv Res. 2017 Jan 23;17(1):74. doi: 10.1186/s12913-017-1995-8.

PMID: 28114939

 

Drug-to-antibody determination for an antibody-drug-conjugate utilizing cathepsin B digestion coupled with reversed-phase high-pressure liquid chromatography analysis.

Adamo M, Sun G, Qiu D, Valente J, Lan W, Song H, Bolgar M, Katiyar A, Krishnamurthy G.

J Chromatogr A. 2017 Jan 20;1481:44-52. doi: 10.1016/j.chroma.2016.12.051.

PMID: 28017567

 

Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD.

Bihlet AR, Karsdal MA, Sand JM, Leeming DJ, Roberts M, White W, Bowler R.

Respir Res. 2017 Jan 19;18(1):22. doi: 10.1186/s12931-017-0509-x.

PMID: 28103932

 

 Dapagliflozin in Patients with Type 1 Diabetes: A post-hoc analysis of the effect of insulin dose adjustments on 24-hour continuously monitored mean glucose and fasting beta-hydroxybutyrate levels from a Phase IIa pilot study.

Henry RR, Dandona P, Pettus J, Mudaliar S, Xu J, Hansen L.

Diabetes Obes Metab. 2017 Jan 18. doi: 10.1111/dom.12882. [Epub ahead of print]

PMID: 28098426

 

[Economic impact of optimising antiretroviral treatment in human immunodeficiency virus-infected adults with suppressed viral load in Spain, by implementing the grade A-1 evidence recommendations of the 2015 GESIDA/National AIDS Plan].

Ribera E, Martínez-Sesmero JM, Sánchez-Rubio J, Rubio R, Pasquau J, Poveda JL, Pérez-Mitru A, Roldán C, Hernández-Novoa B.

Enferm Infecc Microbiol Clin. 2017 Jan 18. pii: S0213-005X(16)30396-2. doi: 10.1016/j.eimc.2016.11.015. [Epub ahead of print] Spanish.

PMID: 28109551

 

Diverse ortho-C(sp2)-H Functionalization of Benzaldehydes Using Transient Directing Groups.

Liu XH, Park H, Hu JH, Hu Y, Zhang QL, Wang BL, Sun B, Yeung KS, Zhang FL, Yu JQ.

J Am Chem Soc. 2017 Jan 18;139(2):888-896. doi: 10.1021/jacs.6b11188.

PMID: 28006102

 

Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Non-Human Primate Renal Allograft Rejection.

Kim SC, Wakwe W, Higginbotham LB, Mathews DV, Breeden CP, Stephenson AC, Jenkins J, Strobert E, Price K, Price L, Kuhn R, Wang H, Yamniuk A, Suchard S, Farris AB 3rd, Pearson TC, Larsen CP, Ford ML, Suri A, Nadler S, Adams AB.

Am J Transplant. 2017 Jan 17. doi: 10.1111/ajt.14197. [Epub ahead of print]

PMID: 28097811

 

Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and Peripheral Artery Disease: Insights From the ARISTOTLE Trial.

Hu PT, Lopes RD, Stevens SR, Wallentin L, Thomas L, Alexander JH, Hanna M, Lewis BS, Verheugt FW, Granger CB, Jones WS.

J Am Heart Assoc. 2017 Jan 17;6(1). pii: e004699. doi: 10.1161/JAHA.116.004699.

PMID: 28096100

 

Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy.

DiMemmo LM, Cameron Varano A, Haulenbeek J, Liang Y, Patel K, Dukes MJ, Zheng S, Hubert M, Piccoli SP, Kelly DF.

Lab Chip. 2017 Jan 17;17(2):315-322. doi: 10.1039/c6lc01160h.

PMID: 27934977

 

Decarboxylative Peptide Macrocyclization through Photoredox Catalysis.

McCarver SJ, Qiao JX, Carpenter J, Borzilleri RM, Poss MA, Eastgate MD, Miller MM, MacMillan DW.

Angew Chem Int Ed Engl. 2017 Jan 16;56(3):728-732. doi: 10.1002/anie.201608207.

PMID: 27860140

 

Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.

Higgins MA, Marcin LR, Christopher Zusi F, Gentles R, Ding M, Pearce BC, Easton A, Kostich WA, Seager MA, Bourin C, Bristow LJ, Johnson KA, Miller R, Hogan J, Whiterock V, Gulianello M, Ferrante M, Huang Y, Hendricson A, Alt A, Macor JE, Bronson JJ.

Bioorg Med Chem. 2017 Jan 15;25(2):496-513. doi: 10.1016/j.bmc.2016.11.018.

PMID: 27914948

 

Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase.

Parcella K, Nickel A, Beno BR, Sheriff S, Wan C, Wang YK, Roberts SB, Meanwell NA, Kadow JF.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):295-298. doi: 10.1016/j.bmcl.2016.11.054.

PMID: 27908764

 

Anticoagulation therapy and clinical outcomes in patients with recently diagnosed atrial fibrillation: Insights from the ARISTOTLE trial.

Guimarães PO, Wojdyla DM, Alexander JH, Thomas L, Alings M, Flaker GC, Al-Khatib SM, Hanna M, Horowitz JD, Wallentin L, Granger CB, Lopes RD.

Int J Cardiol. 2017 Jan 15;227:443-449. doi: 10.1016/j.ijcard.2016.11.014.

PMID: 27852444

 

Approaches to Mitigate the Unwanted Immunogenicity of Therapeutic Proteins during Drug Development.

Salazar-Fontana LI, Desai DD, Khan TA, Pillutla RC, Prior S, Ramakrishnan R, Schneider J, Joseph A.

AAPS J. 2017 Jan 12. doi: 10.1208/s12248-016-0030-z. [Epub ahead of print]

PMID: 28083796

 

Journal of Medicinal Chemistry, Technological Advances: Highlights 2015-2016.

Djuric SW, Meanwell NA.

J Med Chem. 2017 Jan 12;60(1):1-3. doi: 10.1021/acs.jmedchem.6b01600. No abstract available.

PMID: 28076959

 

Comparison of cardiovascular risk algorithms in patients with vs without rheumatoid arthritis and the role of C-reactive protein in predicting cardiovascular outcomes in rheumatoid arthritis.

Alemao E, Cawston H, Bourhis F, Al M, Rutten-van Molken M, Liao KP, Solomon DH.

Rheumatology (Oxford). 2017 Jan 12. pii: kew440. doi: 10.1093/rheumatology/kew440. [Epub ahead of print]

PMID: 28087832

 

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.

Qin LY, Ruan Z, Cherney RJ, Dhar TG, Neels J, Weigelt CA, Sack JS, Srivastava AS, Cornelius LA, Tino JA, Stefanski K, Gu X, Xie J, Susulic V, Yang X, Yarde-Chinn M, Skala S, Bosnius R, Goldstein C, Davies P, Ruepp S, Salter-Cid L, Bhide RS, Poss MA.

Bioorg Med Chem Lett. 2017 Jan 10. pii: S0960-894X(17)30028-8. doi: 10.1016/j.bmcl.2017.01.016. [Epub ahead of print]

PMID: 28108251

 

Efficacy and Safety of Nivolumab Alone or in Combination With Ipilimumab in Patients With Mucosal Melanoma: A Pooled Analysis.

D'Angelo SP, Larkin J, Sosman JA, Lebbé C, Brady B, Neyns B, Schmidt H, Hassel JC, Hodi FS, Lorigan P, Savage KJ, Miller WH Jr, Mohr P, Marquez-Rodas I, Charles J, Kaatz M, Sznol M, Weber JS, Shoushtari AN, Ruisi M, Jiang J, Wolchok JD.

J Clin Oncol. 2017 Jan 10;35(2):226-235.

PMID: 28056206

 

An Integrated Assessment of the Effects of Immunogenicity on the Pharmacokinetics, Safety, and Efficacy of Elotuzumab.

Passey C, Mora J, Dodge R, Gibiansky L, Sheng J, Roy A, Bello A, Gupta M.

AAPS J. 2017 Jan 9. doi: 10.1208/s12248-016-0033-9. [Epub ahead of print]

PMID: 28070715

 

Population Pharmacokinetic Analysis of Daclatasvir in Subjects with Chronic Hepatitis C Virus Infection.

Chan P, Li H, Zhu L, Bifano M, Eley T, Osawa M, Ueno T, Hughes E, Bertz R, Garimella T, AbuTarif M.

Clin Pharmacokinet. 2017 Jan 9. doi: 10.1007/s40262-016-0504-2. [Epub ahead of print]

PMID: 28066880

 

The effectiveness of daclatasvir based therapy in European patients with chronic hepatitis C and advanced liver disease.

Young J, Weis N, Hofer H, Irving W, Weiland O, Giostra E, Pascasio JM, Castells L, Prieto M, Postema R, Lefevre C, Evans D, Bucher HC, Calleja JL.

BMC Infect Dis. 2017 Jan 7;17(1):45. doi: 10.1186/s12879-016-2106-x.

PMID: 28061762

 

A novel reagent significantly improved assay robustness in imaged capillary isoelectric focusing.

Zhang X, Voronov S, Mussa N, Li Z.

Anal Biochem. 2017 Jan 6;521:1-7. doi: 10.1016/j.ab.2016.12.013. [Epub ahead of print]

PMID: 28065577

 

The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton's tyrosine kinase.

Dai J, Wang C, Traeger SC, Discenza L, Obermeier MT, Tymiak AA, Zhang Y.

J Chromatogr A. 2017 Jan 6. pii: S0021-9673(17)30051-1. doi: 10.1016/j.chroma.2017.01.016. [Epub ahead of print]

PMID: 28131592

 

Effective Combination of Innate and Adaptive Immunotherapeutic Approaches in a Mouse Melanoma Model.

Rakhmilevich AL, Felder M, Lever L, Slowinski J, Rasmussen K, Hoefges A, Van De Voort TJ, Loibner H, Korman AJ, Gillies SD, Sondel PM.

J Immunol. 2017 Jan 6. pii: 1601255. doi: 10.4049/jimmunol.1601255. [Epub ahead of print]

PMID: 28062694

 

Control strategies for drug product continuous direct compression - state of control, product collection strategies, and startup/shutdown operations for the production of clinical trial materials and commercial products.

Almaya A, De Belder L, Meyer R, Nagapudi K, Lin HH, Leavesley I, Jayanth J, Bajwa G, DiNunzio J, Tantuccio A, Blackwood D, Abebe A.

J Pharm Sci. 2017 Jan 6. pii: S0022-3549(16)41939-8. doi: 10.1016/j.xphs.2016.12.014. [Epub ahead of print]

PMID: 28069357

 

Antibodies Targeting Closely Adjacent or Minimally Overlapping Epitopes Can Displace One Another.

Abdiche YN, Yeung AY, Ni I, Stone D, Miles A, Morishige W, Rossi A, Strop P.

PLoS One. 2017 Jan 6;12(1):e0169535. doi: 10.1371/journal.pone.0169535.

PMID: 28060885

 

Using Health Care Claims Data to Assess the Prevalence of Hodgkin Lymphoma and Relapsed or Refractory Hodgkin Lymphoma in the United States.

Lin J, Siegartel LR, Lingohr-Smith M, Menges B, Makenbaeva D.

Clin Ther. 2017 Jan 5. pii: S0149-2918(16)30923-7. doi: 10.1016/j.clinthera.2016.12.010. [Epub ahead of print]

PMID: 28065438

 

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.

Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J.

Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5294. doi: 10.1126/scitranslmed.aaf5294.

PMID: 28053157

 

Role of Fc-FcγR interactions in the antitumor activity of therapeutic antibodies.

Barnhart BC, Quigley M.

Immunol Cell Biol. 2017 Jan 3. doi: 10.1038/icb.2016.121. [Epub ahead of print] Review.

PMID: 27974746

 

Kinesiophobia and physical therapy-related pain in musculoskeletal pain: A national multicenter cohort study on patients and their general physicians.

Perrot S, Trouvin AP, Rondeau V, Chartier I, Arnaud R, Milon JY, Pouchain D.

Joint Bone Spine. 2017 Jan 3. pii: S1297-319X(16)30251-2. doi: 10.1016/j.jbspin.2016.12.014. [Epub ahead of print]

PMID: 28062380

 

Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms.

Qin T, Malins LR, Edwards JT, Merchant RR, Novak AJ, Zhong JZ, Mills RB, Yan M, Yuan C, Eastgate MD, Baran PS.

Angew Chem Int Ed Engl. 2017 Jan 2;56(1):260-265. doi: 10.1002/anie.201609662.

PMID: 27981703

 

Copper-Catalyzed Bromination of C(sp3 )-H Bonds Distal to Functional Groups.

Liu T, Myers MC, Yu JQ.

Angew Chem Int Ed Engl. 2017 Jan 2;56(1):306-309. doi: 10.1002/anie.201608210.

PMID: 27897345

 

Accelerating Regulated Bioanalysis for Biotherapeutics: Case Examples Using a Microfluidic Ligand Binding Assay Platform.

Liu R, Hoffpauir B, Chilewski SD, Gamberdella J, Kavita U, Duo J, Gleason C, Zhang Y, Pillutla R, DeSilva B, Hamuro L.

AAPS J. 2017 Jan;19(1):82-91. doi: 10.1208/s12248-016-0006-z.

PMID: 27796911

 

Further Evaluation of Covariate Analysis using Empirical Bayes Estimates in Population Pharmacokinetics: the Perception of Shrinkage and Likelihood Ratio Test.

Xu XS, Yuan M, Yang H, Feng Y, Xu J, Pinheiro J.

AAPS J. 2017 Jan;19(1):264-273. doi: 10.1208/s12248-016-0001-4.

PMID: 27761720

 

Particle Characterization for a Protein Drug Product Stored in Pre-Filled Syringes Using Micro-Flow Imaging, Archimedes, and Quartz Crystal Microbalance with Dissipation.

Zheng S, Puri A, Li J, Jaiswal A, Adams M.

AAPS J. 2017 Jan;19(1):110-116. doi: 10.1208/s12248-016-9983-1.

PMID: 27620008

 

Investigating the Degradation Behaviors of a Therapeutic Monoclonal Antibody Associated with pH and Buffer Species.

Zheng S, Qiu D, Adams M, Li J, Mantri RV, Gandhi R.

AAPS PharmSciTech. 2017 Jan 1;18(1):42-48. doi: 10.1208/s12249-015-0403-0.

PMID: 26340951

 

Efficacy and Safety Outcomes of Extended Criteria Donor Kidneys by Subtype: Subgroup Analysis of BENEFIT-EXT at 7 Years After Transplant.

Florman S, Becker T, Bresnahan B, Chevaile-Ramos A, Carvalho D, Grannas G, Muehlbacher F, O'Connell PJ, Meier-Kriesche HU, Larsen CP.

Am J Transplant. 2017 Jan;17(1):180-190. doi: 10.1111/ajt.13886.

PMID: 27232116

 

Differential mobility spectrometry combined with multiple ion monitoring for bioanalysis of disulfide-bonded peptides with inefficient collision-induced dissociation fragmentation.

Xia YQ, Ciccimaro E, Zheng N, Zhu M.

Bioanalysis. 2017 Jan;9(2):183-192.

PMID: 27960545

 

Characterization of labeled reagents in ligand-binding assays by a surface plasmon resonance biosensor.

Duo J, Bruno J, Piccoli S, DeSilva B, Zhang YJ.

Bioanalysis. 2017 Jan;9(2):193-207.

PMID: 27960543

 

Impact of Warfarin Persistence on Health-Care Utilization and Costs Among Patients With Atrial Fibrillation Managed in Anticoagulation Clinics in the United States.

Deitelzweig SB, Evans M, Trocio J, Gupta K, Lingohr-Smith M, Menges B, Lin J.

Clin Appl Thromb Hemost. 2017 Jan 1:1076029616685427. doi: 10.1177/1076029616685427. [Epub ahead of print]

PMID: 28135822

 

Value of Sustained Virologic Response in Patients with Hepatitis C as a Function of Time to Progression of End-Stage Liver Disease.

Ward T, Gordon J, Jones B, Bennett H, Webster S, Kalsekar A, Yuan Y, Brenner M, McEwan P.

Clin Drug Investig. 2017 Jan;37(1):61-70. doi: 10.1007/s40261-016-0458-z.

PMID: 27587071

 

Improving the tools of clinical pharmacology: Goals for 2017 and beyond.

Zineh I, Abernethy D, Hop C, Bello A, McClellan MB, Daniel GW, Romine MH.

Clin Pharmacol Ther. 2017 Jan;101(1):22-24. doi: 10.1002/cpt.530.

PMID: 27727433

 

Quantitative Systems Pharmacology: A Case for Disease Models.

Musante CJ, Ramanujan S, Schmidt BJ, Ghobrial OG, Lu J, Heatherington AC.

Clin Pharmacol Ther. 2017 Jan;101(1):24-27. doi: 10.1002/cpt.528.

PMID: 27709613

 

Model-Based Population Pharmacokinetic Analysis of Nivolumab in Patients With Solid Tumors.

Bajaj G, Wang X, Agrawal S, Gupta M, Roy A, Feng Y.

CPT Pharmacometrics Syst Pharmacol. 2017 Jan;6(1):58-66. doi: 10.1002/psp4.12143.

PMID: 28019091

 

Quantitative Characterization of the Exposure-Response Relationship for Cancer Immunotherapy: A Case Study of Nivolumab in Patients With Advanced Melanoma.

Wang X, Feng Y, Bajaj G, Gupta M, Agrawal S, Yang A, Park JS, Lestini B, Roy A.

CPT Pharmacometrics Syst Pharmacol. 2017 Jan;6(1):40-48. doi: 10.1002/psp4.12133.

PMID: 28019090

 

Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin.

Johnson M, Patel D, Matheny C, Ho M, Chen L, Ellens H.

Drug Metab Dispos. 2017 Jan;45(1):27-34.

PMID: 27737931

 

A nationwide registry study to compare bleeding rates in patients with atrial fibrillation being prescribed oral anticoagulants.

Halvorsen S, Ghanima W, Fride Tvete I, Hoxmark C, Falck P, Solli O, Jonasson C.

Eur Heart J Cardiovasc Pharmacother. 2017 Jan;3(1):28-36. doi: 10.1093/ehjcvp/pvw031.

PMID: 27680880

 

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results.

Margolskee A, Darwich AS, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, Mazuir F, Nicolas O, Ramusovic S, Xu C, Pathak SM, Korjamo T, Laru J, Malkki J, Pappinen S, Tuunainen J, Dressman J, Hansmann S, Kostewicz E, He H, Heimbach T, Wu F, Hoft C, Laplanche L, Pang Y, Bolger MB, Huehn E, Lukacova V, Mullin JM, Szeto KX, Costales C, Lin J, McAllister M, Modi S, Rotter C, Varma M, Wong M, Mitra A, Bevernage J, Biewenga J, Van Peer A, Lloyd R, Shardlow C, Langguth P, Mishenzon I, Nguyen MA, Brown J, Lennernäs H, Abrahamsson B.

Eur J Pharm Sci. 2017 Jan 1;96:610-625. doi: 10.1016/j.ejps.2016.10.036.

PMID: 27816631

 

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes.

Darwich AS, Margolskee A, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, Mazuir F, Nicolas O, Ramusovic S, Xu C, Pathak SM, Korjamo T, Laru J, Malkki J, Pappinen S, Tuunainen J, Dressman J, Hansmann S, Kostewicz E, He H, Heimbach T, Wu F, Hoft C, Pang Y, Bolger MB, Huehn E, Lukacova V, Mullin JM, Szeto KX, Costales C, Lin J, McAllister M, Modi S, Rotter C, Varma M, Wong M, Mitra A, Bevernage J, Biewenga J, Van Peer A, Lloyd R, Shardlow C, Langguth P, Mishenzon I, Nguyen MA, Brown J, Lennernäs H, Abrahamsson B.

Eur J Pharm Sci. 2017 Jan 1;96:626-642. doi: 10.1016/j.ejps.2016.09.037.

PMID: 27693299

 

In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2'-C-Methylguanosine Prodrug BMS-986094.

Li W, Trouba KJ, Ma L, Kwagh J, Storck C, Zhu Y, Flint O, Humphreys WG, Wang J, Liu A, Wang B, Graziano MJ, Davies MH, Sanderson TP.

Int J Toxicol. 2017 Jan 1:1091581816683642. doi: 10.1177/1091581816683642. [Epub ahead of print]

PMID: 28056568

 

Randomized, Double-Blind, Phase III Trial of Ipilimumab Versus Placebo in Asymptomatic or Minimally Symptomatic Patients With Metastatic Chemotherapy-Naive Castration-Resistant Prostate Cancer.

Beer TM, Kwon ED, Drake CG, Fizazi K, Logothetis C, Gravis G, Ganju V, Polikoff J, Saad F, Humanski P, Piulats JM, Gonzalez Mella P, Ng SS, Jaeger D, Parnis FX, Franke FA, Puente J, Carvajal R, Sengeløv L, McHenry MB, Varma A, van den Eertwegh AJ, Gerritsen W.

J Clin Oncol. 2017 Jan;35(1):40-47.

PMID: 28034081

 

Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody.

Lewis KE, Holdren MS, Maurer MF, Underwood S, Meengs B, Julien SH, Byrnes-Blake KA, Freeman JA, Bukowski TR, Wolf AC, Hamacher NB, Rixon MW, Dillon SR.

J Eur Acad Dermatol Venereol. 2017 Jan;31(1):142-150. doi: 10.1111/jdv.13794.

PMID: 27501029

 

Real-world treatment patterns and clinical outcomes of HCV treatment-naive patients in China: an interim analysis from the CCgenos study.

Rao HY, Li H, Chen H, Shang J, Xie Q, Gao ZL, Li J, Sun Y, Jiang J, Wang L, Zhao L, Zhang L, Yang W, Niu J, Gong Z, Gong G, Yang R, Lee MH, Wei L.

J Gastroenterol Hepatol. 2017 Jan;32(1):244-252. doi: 10.1111/jgh.13467.

PMID: 27289083

 

The synthesis of [1-14 C]2-(1H-tetrazol-5-yl)acetic acid.

Maxwell BD, Tran SB.

J Labelled Comp Radiopharm. 2017 Jan;60(1):49-54. doi: 10.1002/jlcr.3472.

PMID: 27966233

 

Impact of apixaban vs low molecular weight heparin/vitamin k antagonist on hospital resource use in patients with venous thromboembolism.

Browne C, Lanitis T, Hamilton M, Li X, Horbyluk R, Mardekian J, Kongnakorn T, Cohen A.

J Med Econ. 2017 Jan;20(1):98-106.

PMID: 27822962

 

Long-Term Follow-Up of Children Treated With Peginterferon and Ribavirin for Hepatitis C Virus Infection.

Haber B, Alonso E, Pedreira A, Rodriguez-Baez N, Ciocca M, Lacaille F, Lang T, Gonzalez T, Goodman Z, Yang Z, Jackson B, Noviello S, Albrecht JK.

J Pediatr Gastroenterol Nutr. 2017 Jan;64(1):89-94. doi: 10.1097/MPG.0000000000001239.

PMID: 27111344

 

Application of In-line Focused Beam Reflectance Measurement to Brivanib Alaninate Wet Granulation Process to Enable Scale-up and Attribute-based Monitoring and Control Strategies.

Narang AS, Stevens T, Macias K, Paruchuri S, Gao Z, Badawy S.

J Pharm Sci. 2017 Jan;106(1):224-233. doi: 10.1016/j.xphs.2016.08.025.

PMID: 27771049

 

Assessment of Tablet Surface Hardness by Laser Ablation and Its Correlation With the Erosion Tendency of Core Tablets.

Narang AS, Breckenridge L, Guo H, Wang J, Wolf AA, Desai D, Varia S, Badawy S.

J Pharm Sci. 2017 Jan;106(1):200-207. doi: 10.1016/j.xphs.2016.08.008.

PMID: 27686683

 

Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.

Chow EC, Quach HP, Zhang Y, Wang JZ, Evans DC, Li AP, Silva J, Tirona RG, Lai Y, Pang KS.

J Pharmacol Exp Ther. 2017 Jan;360(1):174-191.

PMID: 27789682

 

PD-L1 Expression by Two Complementary Diagnostic Assays and mRNA In Situ Hybridization in Small Cell Lung Cancer.

Yu H, Batenchuk C, Badzio A, Boyle TA, Czapiewski P, Chan DC, Lu X, Gao D, Ellison K, Kowalewski AA, Rivard CJ, Dziadziuszko R, Zhou C, Hussein M, Richards D, Wilks S, Monte M, Edenfield W, Goldschmidt J, Page R, Ulrich B, Waterhouse D, Close S, Jassem J, Kulig K, Hirsch FR.

J Thorac Oncol. 2017 Jan;12(1):110-120. doi: 10.1016/j.jtho.2016.09.002.

PMID: 27639678

 

Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study.

Hellmann MD, Rizvi NA, Goldman JW, Gettinger SN, Borghaei H, Brahmer JR, Ready NE, Gerber DE, Chow LQ, Juergens RA, Shepherd FA, Laurie SA, Geese WJ, Agrawal S, Young TC, Li X, Antonia SJ.

Lancet Oncol. 2017 Jan;18(1):31-41. doi: 10.1016/S1470-2045(16)30624-6.

PMID: 27932067

 

Development of adsorptive hybrid filters to enable two-step purification of biologics.

Singh N, Arunkumar A, Peck M, Voloshin AM, Moreno AM, Tan Z, Hester J, Borys MC, Li ZJ.

MAbs. 2017 Feb/Mar;9(2):350-363. doi: 10.1080/19420862.2016.1267091.

PMID: 27929735

 

HER2 Status in Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma for Entry to the TRIO-013/LOGiC Trial of Lapatinib.

Press MF, Ellis CE, Gagnon RC, Grob TJ, Buyse M, Villalobos I, Liang Z, Wu S, Bang YJ, Qin SK, Chung HC, Xu J, Park JO, Jeziorski K, Afenjar K, Ma Y, Estrada MC, Robinson DM, Scherer SJ, Sauter G, Hecht JR, Slamon DJ.

Mol Cancer Ther. 2017 Jan;16(1):228-238. doi: 10.1158/1535-7163.MCT-15-0887.

PMID: 27811012

 

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects.

Chowdhury GM, Zhang J, Thomas M, Banasr M, Ma X, Pittman B, Bristow L, Schaeffer E, Duman RS, Rothman DL, Behar KL, Sanacora G.

Mol Psychiatry. 2017 Jan;22(1):120-126. doi: 10.1038/mp.2016.34.

PMID: 27067013

 

Clinical Pharmacology Studies in Critically Ill Children.

Thakkar N, Salerno S, Hornik CP, Gonzalez D.

Pharm Res. 2017 Jan;34(1):7-24. doi: 10.1007/s11095-016-2033-y. Review.

PMID: 27585904

 

Principles for Assessing Adversity in Toxicologic Clinical Pathology.

Ramaiah L, Tomlinson L, Tripathi NK, Cregar LC, Vitsky A, von Beust B, Barlow VG, Reagan WJ, Ennulat D.

Toxicol Pathol. 2017 Jan 1:192623316681646. doi: 10.1177/0192623316681646. [Epub ahead of print]

PMID: 28056663

 

Interpreting and Integrating Clinical and Anatomic Pathology Results.

Ramaiah L, Hinrichs MJ, Skuba EV, Iverson WO, Ennulat D.

Toxicol Pathol. 2017 Jan;45(1):223-237. doi: 10.1177/0192623316677068.

PMID: 27879439

Back to Top

2016 Publications

The effect of body mass index on clinical response to abatacept as a first-line biologic for rheumatoid arthritis: 6-month results from the 2-year, observational, prospective ACTION study.

Mariette X, Alten R, Nüßlein HG, Galeazzi M, Lorenz HM, Cantagrel A, Chartier M, Poncet C, Rauch C, Le Bars M.

Joint Bone Spine. 2016 Dec 30. pii: S1297-319X(16)30210-X. doi: 10.1016/j.jbspin.2016.10.011. [Epub ahead of print]

PMID: 28043761

 

Designer vaccine nanodiscs for personalized cancer immunotherapy.

Kuai R, Ochyl LJ, Bahjat KS, Schwendeman A, Moon JJ.

Nat Mater. 2016 Dec 26. doi: 10.1038/nmat4822. [Epub ahead of print]

PMID: 28024156

 

Real-World Experience With Daclatasvir Plus Sofosbuvir ± Ribavirin for Post-Liver Transplant HCV Recurrence and Severe Liver Disease.

Herzer K, Welzel TM, Spengler U, Hinrichsen H, Klinker H, Berg T, Ferenci P, Peck-Radosavljevic M, Inderson A, Zhao Y, Jimenez-Exposito MJ, Zeuzem S.

Transpl Int. 2016 Dec 24. doi: 10.1111/tri.12910. [Epub ahead of print]

PMID: 28012215

 

Effect of minor populations of NS5A and NS5B resistance-associated variants on HCV genotype-3 response to daclatasvir plus sofosbuvir, with or without ribavirin.

McPhee F, Hernandez D, Zhou N.

Antivir Ther. 2016 Dec 23. doi: 10.3851/IMP3120. [Epub ahead of print]

PMID: 28008868

 

Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study.

Goozee R, O'Daly O, Handley R, Reis Marques T, Taylor H, McQueen G, Hubbard K, Pariante C, Mondelli V, Reinders AA, Dazzan P.

Hum Brain Mapp. 2016 Dec 23. doi: 10.1002/hbm.23485. [Epub ahead of print]

PMID: 28009070

 

Cost-effectiveness analysis of the use of daclatasvir + sofosbuvir + ribavirin (16 weeks and 12 weeks) vs sofosbuvir + ribavirin (16 weeks and 24 weeks) for the treatment of cirrhotic patients affected with hepatitis C virus genotype 3 in Italy.

Restelli U, Alberti A, Lazzarin A, Bonfanti M, Nappi C, Croce D.

Eur J Health Econ. 2016 Dec 22. doi: 10.1007/s10198-016-0865-3. [Epub ahead of print]

PMID: 28008546

 

Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.

Yang MG, Xiao Z, Dhar TG, Xiao HY, Gilmore JL, Marcoux D, Xie JH, McIntyre KW, Taylor TL, Borowski V, Heimrich E, Li YW, Feng J, Fernandes A, Yang Z, Balimane P, Marino AM, Cornelius G, Warrack BM, Mathur A, Wu DR, Li P, Gupta A, Pragalathan B, Shen DR, Cvijic ME, Lehman-McKeeman LD, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ.

J Med Chem. 2016 Dec 22;59(24):11138-11147. doi: 10.1021/acs.jmedchem.6b01433.

PMID: 28002964

 

Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.

Cook J, Zusi FC, McDonald IM, King D, Hill MD, Iwuagwu C, Mate RA, Fang H, Zhao R, Wang B, Cutrone J, Ma B, Gao Q, Knox RJ, Matchett M, Gallagher L, Ferrante M, Post-Munson D, Molski T, Easton A, Miller R, Jones K, Digavalli S, Healy F, Lentz K, Benitex Y, Clarke W, Natale J, Siuciak JA, Lodge N, Zaczek R, Denton R, Morgan D, Bristow LJ, Macor JE, Olson RE.

J Med Chem. 2016 Dec 22;59(24):11171-11181. doi: 10.1021/acs.jmedchem.6b01506.

PMID: 27958732

 

Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression.

Degnan AP, Tora GO, Huang H, Conlon DA, Davis CD, Hanumegowda UM, Hou X, Hsiao Y, Hu J, Krause R, Li YW, Newton AE, Pieschl RL, Raybon J, Rosner T, Sun JH, Taber MT, Taylor SJ, Wong MK, Zhang H, Lodge NJ, Bronson JJ, Macor JE, Gillman KW.

ACS Chem Neurosci. 2016 Dec 21;7(12):1635-1640. doi: 10.1021/acschemneuro.6b00337.

PMID: 27744678

 

Evaluation of automated Wes system as an analytical and characterization tool to support monoclonal antibody drug product development.

Wang J, Valdez A, Chen Y.

J Pharm Biomed Anal. 2016 Dec 21. pii: S0731-7085(16)30669-0. doi: 10.1016/j.jpba.2016.12.024. [Epub ahead of print]

PMID: 28069351

 

Phase 2 Placebo-Controlled, Double-Blind Trial of Dasatinib Added to Gemcitabine for Patients with Locally-Advanced Pancreatic Cancer.

Evans TR, Van Cutsem E, Moore MJ, Bazin IS, Rosemurgy A, Bodoky G, Deplanque G, Harrison M, Melichar B, Pezet D, Elekes A, Rock E, Lin C, Strauss L, O'Dwyer PJ.

Ann Oncol. 2016 Dec 19. pii: mdw607. doi: 10.1093/annonc/mdw607. [Epub ahead of print]

PMID: 27998964

 

Revised Reply to Letter to the Editor with regards to manuscript AR-15-1750.R1.

Fleischmann R, Connolly SE, Maldonado MA, Schiff M.

Arthritis Rheumatol. 2016 Dec 19. doi: 10.1002/art.40021. [Epub ahead of print] No abstract available.

PMID: 27992708

 

Systematic interpolation method predicts protein chromatographic elution with salt gradients, pH gradients and combined salt/pH gradients.

Creasy A, Barker G, Carta G.

Biotechnol J. 2016 Dec 19. doi: 10.1002/biot.201600636. [Epub ahead of print]

PMID: 27992113

 

Drug-Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization.

Gan J, Zhang H, Humphreys WG.

Chem Res Toxicol. 2016 Dec 19;29(12):2040-2057.

PMID: 27989144

 

Functionalized triazines as potent HCV entry inhibitors.

Mull ES, Sun LQ, Zhao Q, Eggers B, Pokornowski K, Zhai G, Rajamani R, Jenkins S, Kramer M, Wang YK, Fang H, Tenney D, Baldick CJ, Cockett MI, Meanwell NA, Scola PM.

Bioorg Med Chem Lett. 2016 Dec 18. pii: S0960-894X(16)31304-X. doi: 10.1016/j.bmcl.2016.12.038. [Epub ahead of print]

PMID: 28089701

 

Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential.

Degnan AP, Maxwell D, Balakrishnan A, Brown JM, Easton A, Gulianello M, Hanumegowda U, Hill-Drzewi M, Miller R, Santone KS, Senapati A, Shields EE, Sivarao DV, Westphal R, Whiterock VJ, Zhuo X, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5871-5876. doi: 10.1016/j.bmcl.2016.11.014.

PMID: 27856084

 

Characterization of TAP Ambr 250 disposable bioreactors, as a reliable scale-down model for biologics process development.

Xu P, Clark C, Ryder T, Sparks C, Zhou J, Wang M, Russell R, Scott C.

Biotechnol Prog. 2016 Dec 15. doi: 10.1002/btpr.2417. [Epub ahead of print]

PMID: 27977912

 

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel TM.

Nature. 2016 Dec 15;540(7633):458-461. doi: 10.1038/nature20605.

PMID: 27926736

 

Enhancing tablet disintegration characteristics of a highly water-soluble high-drug-loading formulation by granulation process.

Pandey P, Levins C, Pafiakis S, Zacour B, Bindra DS, Trinh J, Buckley D, Gour S, Sharif S, Stamato H.

Pharm Dev Technol. 2016 Dec 15:1-9. [Epub ahead of print]

PMID: 27879156

 

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43.

Wu W, Sun M, Chen F, Cao AT, Liu H, Zhao Y, Huang X, Xiao Y, Yao S, Zhao Q, Liu Z, Cong Y.

Mucosal Immunol. 2016 Dec 14. doi: 10.1038/mi.2016.114. [Epub ahead of print]

PMID: 27966553

 

Real-World Assessment of Renal and Bone Safety among Patients with HIV Infection Exposed to Tenofovir Disoproxil Fumarate-Containing Single-Tablet Regimens.

Nkhoma ET, Rosenblatt L, Myers J, Villasis-Keever A, Coumbis J.

PLoS One. 2016 Dec 12;11(12):e0166982. doi: 10.1371/journal.pone.0166982.

PMID: 27941989

  

Short-duration treatment for chronic hepatitis C virus with daclatasvir, asunaprevir, beclabuvir and sofosbuvir (FOURward study).

Sulkowski MS, Flamm S, Kayali Z, Lawitz EJ, Kwo P, McPhee F, Torbeyns A, Hughes EA, Swenson ES, Yin PD, Linaberry M.

Liver Int. 2016 Dec 10. doi: 10.1111/liv.13335. [Epub ahead of print]

PMID: 27943563

 

The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury.

Zeng L, Yang XT, Li HS, Li Y, Yang C, Gu W, Zhou YH, Du J, Wang HY, Sun JH, Wen DL, Jiang JX.

Respir Res. 2016 Dec 7;17(1):164.

PMID: 27923370

 

 Safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in antiretroviral-experienced subjects: week 48 analysis of AI438011, a Phase IIb, randomized controlled trial.

Thompson M, Lalezari JP, Kaplan R, Pinedo Y, Pena OA, Cahn P, Stock DA, Joshi SR, Hanna GJ, Lataillade M; AI.; study team..

Antivir Ther. 2016 Dec 6. doi: 10.3851/IMP3112. [Epub ahead of print]

PMID: 27922453

 

A carbon dioxide stripping model for mammalian cell culture in manufacturing scale bioreactors.

Xing Z, Lewis AM, Borys MC, Li ZJ.

Biotechnol Bioeng. 2016 Dec 6. doi: 10.1002/bit.26232. [Epub ahead of print]

PMID: 27922179

 

John Staniforth-An appreciation: The non-conformist nonconformist.

Tobyn M, Price R.

Int J Pharm. 2016 Dec 5;514(2):333-334. doi: 10.1016/j.ijpharm.2016.10.028. No abstract available.

PMID: 27780744

 

Development of aqueous dispersions of Coenzyme Q10 for pulmonary delivery and the dynamics of active vibrating-mesh aerosolization.

Carvalho TC, McCook JP, Narain NR, McConville JT.

Int J Pharm. 2016 Dec 5;514(2):407-419. doi: 10.1016/j.ijpharm.2016.10.011.

PMID: 27732894

 

Pre-absorption physicochemical compatibility assessment of 8-drug metabolic cocktail.

Tye CK, Wang Z, Dockens RC, Vakkalagadda B, Wang C, Zhang Y, Su CC, Hageman MJ.

Int J Pharm. 2016 Dec 5;514(2):364-373. doi: 10.1016/j.ijpharm.2016.06.028.

PMID: 27291974

 

Use of similarity scoring in the development of oral solid dosage forms.

Ferreira AP, Olusanmi D, Sprockel O, Abebe A, Nikfar F, Tobyn M.

Int J Pharm. 2016 Dec 5;514(2):335-340. doi: 10.1016/j.ijpharm.2015.09.046.

PMID: 26423176

 

Discrepancies in column parameters presented in hydrophobic subtraction model manuscripts.

Shackman JG.

J Chromatogr A. 2016 Dec 2;1475:116-118. doi: 10.1016/j.chroma.2016.11.006. No abstract available.

PMID: 27842900

 

Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists.

Hill MD, Fang H, King HD, Iwuagwu CI, McDonald IM, Cook J, Zusi FC, Mate RA, Knox RJ, Post-Munson D, Easton A, Miller R, Lentz K, Clarke W, Benitex Y, Lodge N, Zaczek R, Denton R, Morgan D, Bristow L, Macor JE, Olson R.

ACS Med Chem Lett. 2016 Dec 1;8(1):133-137. doi: 10.1021/acsmedchemlett.6b00471.

PMID: 28105289

 

Reasons for non-intensification of treatment in people with type 2 diabetes receiving oral monotherapy: Outcomes from the prospective DIAttitude study.

Balkau B, Halimi S, Blickle JF, Vergès B, Avignon A, Attali C, Chartier I, Amelineau E.

Ann Endocrinol (Paris). 2016 Dec;77(6):649-657. doi: 10.1016/j.ando.2016.03.001.

PMID: 27646493

 

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 3 - LBA, biomarkers and immunogenicity).

Richards S, Amaravadi L, Pillutla R, Birnboeck H, Torri A, Cowan KJ, Papadimitriou A, Garofolo F, Satterwhite C, Piccoli S, Wu B, Krinos-Fiorotti C, Allinson J, Berisha F, Cocea L, Croft S, Fraser S, Galliccia F, Gorovits B, Gupta S, Gupta V, Haidar S, Hottenstein C, Ishii-Watabe A, Jani D, Kadavil J, Kamerud J, Kramer D, Litwin V, Lima Santos GM, Nelson R, Ni Y, Pedras-Vasconcelos J, Qiu Y, Rhyne P, Safavi A, Saito Y, Savoie N, Scheibner K, Schick E, Siguenza PY, Smeraglia J, Staack RF, Subramanyam M, Sumner G, Thway T, Uhlinger D, Ullmann M, Vitaliti A, Welink J, Whiting CC, Xue L, Zeng R.

Bioanalysis. 2016 Dec;8(23):2475-2496.

PMID: 27855512

 

UHPLC-MS/MS bioanalysis of urinary DHEA, cortisone and their hydroxylated metabolites as potential biomarkers for CYP3A-mediated drug-drug interactions.

Zheng N, Christopher LJ, Ma X, Ji QC, Buzescu A, Kandoussi H, Garonzik SM, LaCreta F, Aubry AF, Arnold ME, Zeng J.

Bioanalysis. 2016 Dec;8(23):2429-2443.

PMID: 27855510

 

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 2 - Hybrid LBA/LCMS and input from regulatory agencies).

Song A, Lee A, Garofolo F, Kaur S, Duggan J, Evans C, Palandra J, Donato LD, Xu K, Bauer R, Bustard M, Chen L, Cocea L, Croft S, Galliccia F, Haidar S, Hughes N, Ishii-Watabe A, Islam R, Jones B, Kadavil J, Krantz C, Lima Santos GM, Olah T, Pedras-Vasconcelos J, Staelens L, Saito Y, Savoie N, Scheibner K, Spitz S, Tampal N, Thomas E, Vinter S, Wakelin-Smith J, Welink J, Zeng J, Zhou S.

Bioanalysis. 2016 Dec;8(23):2457-2474.

PMID: 27855509

 

A simple, fast, sensitive and robust LC-MS/MS bioanalytical assay for evaluating 7α-hydroxy-4-cholesten-3-one biomarker in a clinical program.

Yuan L, Luo Y, Kandoussi H, Ji QC.

Bioanalysis. 2016 Dec;8(23):2445-2455.

PMID: 27855505

 

Robust Ki67 detection in human blood by flow cytometry for clinical studies.

Sun Y, Yang K, Bridal T, Ehrhardt AG.

Bioanalysis. 2016 Dec;8(23):2399-2413.

PMID: 27807982

 

Allosteric activation of midazolam CYP3A5 hydroxylase activity by icotinib - Enhancement by ketoconazole.

Zhuang X, Zhang T, Yue S, Wang J, Luo H, Zhang Y, Li Z, Che J, Yang H, Li H, Zhu M, Lu C.

Biochem Pharmacol. 2016 Dec 1;121:67-77. doi: 10.1016/j.bcp.2016.09.012.

PMID: 27666601

 

[2.2.1]-Bicyclic sultams as potent androgen receptor antagonists.

Shan W, Balog A, Nation A, Zhu X, Chen J, Cvijic ME, Geng J, Rizzo CA, Spires T Jr, Attar RM, Obermeier M, Traeger S, Dai J, Zhang Y, Galella M, Trainor G, Vite GD, Gavai AV.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5707-5711. doi: 10.1016/j.bmcl.2016.10.059.

PMID: 27836399

 

Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.

Wu YJ, Guernon J, Rajamani R, Toyn JH, Ahlijanian MK, Albright CF, Muckelbauer J, Chang C, Camac D, Macor JE, Thompson LA.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5729-5731. doi: 10.1016/j.bmcl.2016.10.055.

PMID: 27816517

 

Effects of elotuzumab on QT interval and cardiac safety in patients with multiple myeloma.

Passey C, Darbenzio R, Jou YM, Lynch M, Gupta M.

Cancer Chemother Pharmacol. 2016 Dec;78(6):1237-1244.

PMID: 27796540

 

A Systematic Literature Review on the Cost-Effectiveness of Apixaban for Stroke Prevention in Non-valvular Atrial Fibrillation.

Pinyol C, Cepeda JM, Roldan I, Roldan V, Jimenez S, Gonzalez P, Soto J.

Cardiol Ther. 2016 Dec;5(2):171-186.

PMID: 27457613

 

Using Population Pharmacokinetic and Pharmacodynamic Analyses of Entecavir in Pediatric Subjects to Simplify Dosing Recommendations.

Chan P, Mould DR, Tarif MA, Reynolds L, LaCreta F, Bertz R, Bifano M.

Clin Pharmacokinet. 2016 Dec;55(12):1559-1572.

PMID: 27319000

 

Atazanavir and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Patients: A Systematic Review.

Chow D, Shikuma C, Ritchings C, Guo M, Rosenblatt L.

Infect Dis Ther. 2016 Dec;5(4):473-489. Review.

PMID: 27677263

 

Characterization of NS5A polymorphisms and their impact on response rates in patients with HCV genotype 2 treated with daclatasvir-based regimens.

Zhou N, Han Z, Hartman-Neumann S, DeGray B, Ueland J, Vellucci V, Hernandez D, McPhee F.

J Antimicrob Chemother. 2016 Dec;71(12):3495-3505.

PMID: 27605597

 

Collaborating to improve the use of free-energy and other quantitative methods in drug discovery.

Sherborne B, Shanmugasundaram V, Cheng AC, Christ CD, DesJarlais RL, Duca JS, Lewis RA, Loughney DA, Manas ES, McGaughey GB, Peishoff CE, van Vlijmen H.

J Comput Aided Mol Des. 2016 Dec;30(12):1139-1141. doi: 10.1007/s10822-016-9996-y.

PMID: 28013427

 

Nationwide survey of specialist knowledge on current standard of care (Peg-IFN/RBV) and barriers of care in chronic hepatitis C patients in China.

Wei L, Li J, Yang X, Wang G, Feng B, Hou J, Duan Z, Jia J, Ren H, Niu J, Chen X, Wang FS, Shang J, Bo Q, Li R, Liu Y, Zhuang H.

J Gastroenterol Hepatol. 2016 Dec;31(12):1995-2003. doi: 10.1111/jgh.13399.

PMID: 27043040

 

The syntheses of isotopically labelled CB-1 antagonists for the treatment of obesity.

Tran SB, Maxwell BD, Burrell R, Bonacorsi SJ Jr.

J Labelled Comp Radiopharm. 2016 Dec;59(14):665-672. doi: 10.1002/jlcr.3433.

PMID: 27624665

 

The synthesis and analysis of [phenyl-14 C(U)]BMS-770767 and [13 C6 ]BMS-770767 for use in discovery biotransformation, human ADME and bioanalytical studies.

Maxwell BD, Bonacorsi SJ Jr.

J Labelled Comp Radiopharm. 2016 Dec;59(14):657-664. doi: 10.1002/jlcr.3428.

PMID: 27460954

 

Literature review of the distribution of hepatitis C virus genotypes across Europe.

Alberti A, Lacoin L, Morais E, Lefevre C, Abogunrin S, Iheanacho I.

J Med Virol. 2016 Dec;88(12):2157-2169. doi: 10.1002/jmv.24573.

PMID: 27171396

 

Resolution and Sensitivity of Inline Focused Beam Reflectance Measurement During Wet Granulation in Pharmaceutically Relevant Particle Size Ranges.

Narang AS, Stevens T, Hubert M, Paruchuri S, Macias K, Bindra D, Gao Z, Badawy S.

J Pharm Sci. 2016 Dec;105(12):3594-3602. doi: 10.1016/j.xphs.2016.09.001.

PMID: 27745886

 

Technical Decision Making With Higher Order Structure Data: Perspectives on Higher Order Structure Characterization From the Biopharmaceutical Industry.

Weiss WF 4th, Gabrielson JP, Al-Azzam W, Chen G, Davis DL, Das TK, Hayes DB, Houde D, Singh SK.

J Pharm Sci. 2016 Dec;105(12):3465-3470. doi: 10.1016/j.xphs.2016.09.003.

PMID: 27743675

 

Autoxidation of betulonaldehyde.

Ayers S, Benkovics T, Marshall J, Tan Y.

Planta Med. 2016 Dec;81(S 01):S1-S381. No abstract available.

PMID: 27975757

 

Tackling the burden of the hepatitis C virus in the UK: characterizing and assessing the clinical and economic consequences.

Ward T, Gordon J, Bennett H, Webster S, Sugrue D, Jones B, Brenner M, McEwan P.

Public Health. 2016 Dec;141:42-51. doi: 10.1016/j.puhe.2016.08.002.

PMID: 27932014

 

Progression-free survival, overall survival and quality of life: What is their medicoeconomic importance in oncology?

Pavlovic M, Garnier J, Durand-Zaleski I; participants of Round Table n(o) 3 of Giens XXXI., Bilbault P, Gaudin AF, Le Jeunne C, Lalaude O, Roze S, de Sahb R, Sapède C.

Therapie. 2016 Dec;71(6):625-632. doi: 10.1016/j.therap.2016.03.004.

PMID: 27639631

 

Evaluation of microRNAs-208 and 133a/b as differential biomarkers of acute cardiac and skeletal muscle toxicity in rats.

Calvano J, Achanzar W, Murphy B, DiPiero J, Hixson C, Parrula C, Burr H, Mangipudy R, Tirmenstein M.

Toxicol Appl Pharmacol. 2016 Dec 1;312:53-60. doi: 10.1016/j.taap.2015.11.015.

PMID: 26627004

 

MicroRNA as biomarkers of mitochondrial toxicity.

Baumgart BR, Gray KL, Woicke J, Bunch RT, Sanderson TP, Van Vleet TR.

Toxicol Appl Pharmacol. 2016 Dec 1;312:26-33. doi: 10.1016/j.taap.2015.10.007.

PMID: 26476301

 

The Cost of Costing Treatments Incorrectly: Errors in the Application of Drug Prices in Economic Evaluation Due to Failing to Account for the Distribution of Patient Weight.

Hatswell AJ, Porter J, Lee D, Hertel N, Latimer NR.

Value Health. 2016 Dec;19(8):1055-1058. doi: 10.1016/j.jval.2016.04.013.

PMID: 27987632

 

A Cost-Effectiveness Analysis of Nivolumab Compared with Ipilimumab for the Treatment of BRAF Wild-Type Advanced Melanoma in Australia.

Bohensky MA, Pasupathi K, Gorelik A, Kim H, Harrison JP, Liew D.

Value Health. 2016 Dec;19(8):1009-1015. doi: 10.1016/j.jval.2016.05.013.

PMID: 27987627

 

Reducing blood volume requirements for clinical pathology testing in toxicologic studies-points to consider.

Poitout-Belissent F, Aulbach A, Tripathi N, Ramaiah L.

Vet Clin Pathol. 2016 Dec;45(4):534-551. doi: 10.1111/vcp.12429.

PMID: 27935623

 

Additive free preparative chiral SFC separations of 2,2-dimethyl-3-aryl-propanoic acids.

Wu DR, Yip SH, Li P, Sun D, Kempson J, Mathur A.

J Pharm Biomed Anal. 2016 Nov 30;131:54-63. doi: 10.1016/j.jpba.2016.08.009.

PMID: 27522108

 

Use of Spray-Dried Dispersions in Early Pharmaceutical Development: Theoretical and Practical Challenges.

Li J, Patel D, Wang G.

AAPS J. 2016 Nov 28. [Epub ahead of print]

PMID: 27896684

 

Population Pharmacokinetics of an Extended-Release Formulation of Exenatide Following Single- and Multiple-Dose Administration.

Cirincione B, Edwards J, Mager DE.

AAPS J. 2016 Nov 28. [Epub ahead of print]

PMID: 27896683

 

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors.

Lin Z, Cantone J, Lu H, Nowicka-Sans B, Protack T, Yuan T, Yang H, Liu Z, Drexler D, Regueiro-Ren A, Meanwell NA, Cockett M, Krystal M, Lataillade M, Dicker IB.

PLoS Pathog. 2016 Nov 28;12(11):e1005990. doi: 10.1371/journal.ppat.1005990.

PMID: 27893830

 

Surface induced three-peak elution behavior of a monoclonal antibody during cation exchange chromatography.

Guo J, Creasy AD, Barker G, Carta G.

J Chromatogr A. 2016 Nov 25;1474:85-94. doi: 10.1016/j.chroma.2016.10.061.

PMID: 27802880

 

Allogeneic human mesenchymal stem cells in patients with idiopathic pulmonary fibrosis via intravenous delivery (AETHER): a phase I, safety, clinical trial.

Glassberg MK, Minkiewicz J, Toonkel RL, Simonet ES, Rubio GA, Difede D, Shafazand S, Khan A, Pujol MV, LaRussa VF, Lancaster LH, Rosen GD, Fishman J, Mageto YN, Mendizabal A, Hare JM.

Chest. 2016 Nov 24. pii: S0012-3692(16)62462-5. doi: 10.1016/j.chest.2016.10.061. [Epub ahead of print]

PMID: 27890713

 

A novel liquid chromatography tandem mass spectrometry method for the estimation of bilirubin glucuronides and its application to in vitro enzyme assays.

Putluru SP, Matta MK, Ahire D, Subramanian M, Sinz M, Mandlekar S.

Drug Metab Lett. 2016 Nov 24. [Epub ahead of print]

PMID: 27908259

 

Safety and Efficacy Outcomes 3 Years After Switching to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients: Results From a Phase 2 Randomized Trial.

Grinyó JM, Del Carmen Rial M, Alberu J, Steinberg SM, Manfro RC, Nainan G, Vincenti F, Jones-Burton C, Kamar N.

Am J Kidney Dis. 2016 Nov 23. pii: S0272-6386(16)30572-8. doi: 10.1053/j.ajkd.2016.09.021. [Epub ahead of print]

PMID: 27889299



Synthesis of unlabelled and stable-isotope-labelled glucuronide metabolites of dapagliflozin and synthesis of stable-isotope-labelled dapagliflozin.

Cao K, Brailsford JA, Yao M, Caceres-Cortes J, Espina R, Bonacorsi SJ Jr.

J Labelled Comp Radiopharm. 2016 Nov 21. doi: 10.1002/jlcr.3484. [Epub ahead of print]

PMID: 27868223

 

A comparison of the variance estimation methods for heteroscedastic nonlinear models.

Sidik K, Jonkman JN.

Stat Med. 2016 Nov 20;35(26):4856-4874. doi: 10.1002/sim.7024.

PMID: 27383279

 

Readmission Risk in Chronic Obstructive Pulmonary Disease Patients: Comparative Study of Nebulized β2-Agonists.

Bollu V, Guérin A, Gauthier G, Hiscock R, Wu EQ.

Drugs Real World Outcomes. 2016 Nov 18. [Epub ahead of print]

PMID: 27864792

 

Investigation of the "true" extraction recovery of analytes from multiple types of tissues and its impact on tissue bioanalysis using two model compounds.

Yuan L, Ma L, Dillon L, Fancher RM, Sun H, Zhu M, Lehman-McKeeman L, Aubry AF, Ji QC.

Anal Chim Acta. 2016 Nov 16;945:57-66. doi: 10.1016/j.aca.2016.09.039.

PMID: 27968716

 

COMBINED TREATMENT WITH SAXAGLIPTIN PLUS DAPAGLIFLOZIN REDUCES INSULIN LEVELS BY INCREASED INSULIN CLEARANCE AND IMPROVES β-CELL FUNCTION.

Ekholm E, Hansen L, Johnsson E, Iqbal N, Carlsson B, Chen H, Hirshberg B.

Endocr Pract. 2016 Nov 16. [Epub ahead of print]

PMID: 27849380

 

Daclatasvir plus sofosbuvir, with or without ribavirin, in real-world patients with HIV-HCV coinfection and advanced liver disease.

Rockstroh JK, Ingiliz P, Petersen J, Peck-Radosavljevic M, Welzel TM, Van der Valk M, Zhao Y, Exposito MJ, Zeuzem S.

Antivir Ther. 2016 Nov 15. doi: 10.3851/IMP3108. [Epub ahead of print]

PMID: 27845298

 

Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma.

Choueiri TK, Fishman MN, Escudier B, McDermott DF, Drake CG, Kluger H, Stadler WM, Perez-Gracia JL, McNeel DG, Curti B, Harrison MR, Plimack ER, Appleman L, Fong L, Albiges L, Cohen L, Young TC, Chasalow SD, Ross-Macdonald P, Srivastava S, Jure-Kunkel M, Kurland JF, Simon JS, Sznol M.

Clin Cancer Res. 2016 Nov 15;22(22):5461-5471. doi: 10.1158/1078-0432.CCR-15-2839.

PMID: 27169994

 

 Elotuzumab with lenalidomide and dexamethasone for Japanese patients with relapsed/refractory multiple myeloma: phase 1 study.

Iida S, Nagai H, Kinoshita G, Miyoshi M, Robbins M, Pandya D, Bleickardt E, Chou T.

Int J Hematol. 2016 Nov 15. [Epub ahead of print]

PMID: 27848182

 

Nivolumab dose selection: challenges, opportunities, and lessons learned for cancer immunotherapy.

Agrawal S, Feng Y, Roy A, Kollia G, Lestini B.

J Immunother Cancer. 2016 Nov 15;4:72.

PMID: 27879974

 

Safety Profile of Nivolumab Monotherapy: A Pooled Analysis of Patients With Advanced Melanoma.

Weber JS, Hodi FS, Wolchok JD, Topalian SL, Schadendorf D, Larkin J, Sznol M, Long GV, Li H, Waxman IM, Jiang J, Robert C.

J Clin Oncol. 2016 Nov 14:JCO2015661389. [Epub ahead of print]

PMID: 28068177

 

Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.

Xiao HY, Watterson SH, Langevine CM, Srivastava AS, Ko SS, Zhang Y, Cherney RJ, Guo WW, Gilmore JL, Sheppeck JE 2nd, Wu DR, Li P, Ramasamy D, Arunachalam P, Mathur A, Taylor TL, Shuster DJ, McIntyre KW, Shen DR, Yarde M, Cvijic ME, Marino AM, Balimane PV, Yang Z, Banas DM, Cornelius G, D'Arienzo CJ, Warrack BM, Lehman-McKeeman L, Salter-Cid LM, Xie J, Barrish JC, Carter PH, Dyckman AJ, Dhar TG.

J Med Chem. 2016 Nov 10;59(21):9837-9854.

PMID: 27726358

 

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.

Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML.

N Engl J Med. 2016 Nov 10;375(19):1856-1867.

PMID: 27718784

 

Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy.

Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, Lebbé C, Ferraresi V, Smylie M, Weber JS, Maio M, Bastholt L, Mortier L, Thomas L, Tahir S, Hauschild A, Hassel JC, Hodi FS, Taitt C, de Pril V, de Schaetzen G, Suciu S, Testori A.

N Engl J Med. 2016 Nov 10;375(19):1845-1855.

PMID: 27717298

 

Untargeted screening of unknown xenobiotics and potential toxins in plasma of poisoned patients using high-resolution mass spectrometry: Generation of xenobiotic fingerprint using background subtraction.

Chen C, Wohlfarth A, Xu H, Su D, Wang X, Jiang H, Feng Y, Zhu M.

Anal Chim Acta. 2016 Nov 9;944:37-43. doi: 10.1016/j.aca.2016.09.034.

PMID: 27776637

 

Pd-Catalyzed γ-C(sp3)-H Arylation of Free Amines Using a Transient Directing Group.

Wu Y, Chen YQ, Liu T, Eastgate MD, Yu JQ.

J Am Chem Soc. 2016 Nov 9;138(44):14554-14557.

PMID: 27786439

 

Development of an HTS-Compatible Assay for Discovery of Melanoma-Related Microphthalmia Transcription Factor Disruptors Using AlphaScreen Technology.

Wang J, Fang P, Chase P, Tshori S, Razin E, Spicer TP, Scampavia L, Hodder P, Guo M.

J Biomol Screen. 2016 Nov 8. pii: 1087057116675274. [Epub ahead of print]

PMID: 27827304

 

Advances in analytical methodologies to guide bioprocess engineering for bio-therapeutics.

Saldova R, Kilcoyne M, Stöckmann H, Millán Martín S, Lewis AM, Tuite CM, Gerlach JQ, Le Berre M, Borys MC, Li ZJ, Abu-Absi NR, Leister K, Joshi L, Rudd PM.

Methods. 2016 Nov 8. pii: S1046-2023(16)30434-0. doi: 10.1016/j.ymeth.2016.11.002. [Epub ahead of print]

PMID: 27832969

 

A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma.

Yau TC, Lencioni R, Sukeepaisarnjaroen W, Chao Y, Yen CJ, Lausoontornsiri W, Chen PJ, Sanpajit T, Camp A, Cox DS, Gagnon RC, Liu Y, Raffensperger KE, Kulkarni DA, Kallender H, Ottesen LH, Poon RT, Bottaro DP.

Clin Cancer Res. 2016 Nov 7. pii: clincanres.1789.2016. [Epub ahead of print]

PMID: 27821605

 

Understanding the Impact of Chemical Variability and Calibration Algorithms on Prediction of Solid Fraction of Roller Compacted Ribbons Using Near-Infrared (NIR) Spectroscopy.

Talwar S, Nunes C, Stevens T, Nesarikar V, Timmins P, Anderson CA, Drennen JK 3rd.

Appl Spectrosc. 2016 Nov 4. pii: 0003702816671960. [Epub ahead of print]

PMID: 27815436

 

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

Patel MA, Kim JE, Theodros D, Tam A, Velarde E, Kochel CM, Francica B, Nirschl TR, Ghasemzadeh A, Mathios D, Harris-Bookman S, Jackson CC, Jackson C, Ye X, Tran PT, Tyler B, Coric V, Selby M, Brem H, Drake CG, Pardoll DM, Lim M.

J Immunother Cancer. 2016 Nov 4;4:74.

PMID: 27822377

 

Reply to Letter to the Editor.

Fleischmann R, Connolly SE, Maldonado MA, Schiff M.

Arthritis Rheumatol. 2016 Nov 3. doi: 10.1002/art.39978. [Epub ahead of print] Review. No abstract available.

PMID: 27813366

 

Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ.

N Engl J Med. 2016 Nov 3;375(18):1749-1755.

PMID: 27806233

 

Strategies to Determine Assay Format for the Assessment of Neutralizing Antibody Responses to Biotherapeutics.

Wu B, Chung S, Jiang XR, McNally J, Pedras-Vasconcelos J, Pillutla R, White JT, Xu Y, Gupta S.

AAPS J. 2016 Nov;18(6):1335-1350.

PMID: 27495119

 

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.

Argikar UA, Potter PM, Hutzler JM, Marathe PH.

AAPS J. 2016 Nov;18(6):1391-1405. Review.

PMID: 27495117

 

Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors.

Richter JM, Cheney DL, Bates JA, Wei A, Luettgen JM, Rendina AR, Harper TM, Narayanan R, Wong PC, Seiffert D, Wexler RR, Priestley ES.

ACS Med Chem Lett. 2016 Nov 1;8(1):67-72. doi: 10.1021/acsmedchemlett.6b00375.

PMID: 28105277

 

A Review of Daclatasvir Drug-Drug Interactions.

Garimella T, You X, Wang R, Huang SP, Kandoussi H, Bifano M, Bertz R, Eley T.

Adv Ther. 2016 Nov;33(11):1867-1884. Review.

PMID: 27664109

 

 Long-Term Outcomes in Belatacept- Versus Cyclosporine-Treated Recipients of Extended Criteria Donor Kidneys: Final Results From BENEFIT-EXT, a Phase III Randomized Study.

Durrbach A, Pestana JM, Florman S, Del Carmen Rial M, Rostaing L, Kuypers D, Matas A, Wekerle T, Polinsky M, Meier-Kriesche HU, Munier S, Grinyó JM.

Am J Transplant. 2016 Nov;16(11):3192-3201. doi: 10.1111/ajt.13830.

PMID: 27130868

 

Daclatasvir and Peginterferon/Ribavirin for Black/African-American and Latino Patients with HCV infection.

Rodriguez-Torres M, Lawitz E, Yangco B, Jeffers L, Han SH, Thuluvath PJ, Rustgi V, Harrison S, Ghalib R, Vierling JM, Luketic V, Zamor PJ, Ravendhran N, Morgan TR, Pearlman B, O'Brien C, Khallafi H, Pyrsopoulos N, Kong G, McPhee F, Yin PD, Hughes E, Treitel M.

Ann Hepatol. 2016 Nov-Dec 2016;15(6):834-845.

PMID: 27740516

 

Elotuzumab in combination with thalidomide and low-dose dexamethasone: a phase 2 single-arm safety study in patients with relapsed/refractory multiple myeloma.

Mateos MV, Granell M, Oriol A, Martinez-Lopez J, Blade J, Hernandez MT, Martín J, Gironella M, Lynch M, Bleickardt E, Paliwal P, Singhal A, San-Miguel J.

Br J Haematol. 2016 Nov;175(3):448-456. doi: 10.1111/bjh.14263.

PMID: 27434748

 

Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor.

Ngiow SF, Young A, Blake SJ, Hill GR, Yagita H, Teng MW, Korman AJ, Smyth MJ.

Cancer Res. 2016 Nov 1;76(21):6266-6277.

PMID: 27634762

 

Highlights From the American Association of Pharmaceutical Scientists/ International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations.

Ronaldson PT, Bauer B, El-Kattan AF, Shen H, Salphati L, Louie SW.

Clin Pharmacol Ther. 2016 Nov;100(5):419-422. doi: 10.1002/cpt.439.

PMID: 27500791

 

Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects.

Theunissen PT, Beken S, Beyer BK, Breslin WJ, Cappon GD, Chen CL, Chmielewski G, De Schaepdrijver L, Enright B, Foreman JE, Harrouk W, Hew KW, Hoberman AM, Hui JY, Knudsen TB, Laffan SB, Makris SL, Martin M, McNerney ME, Siezen CL, Stanislaus DJ, Stewart J, Thompson KE, Tornesi B, Van der Laan JW, Weinbauer GF, Wood S, Piersma AH.

Crit Rev Toxicol. 2016 Nov;46(10):900-910.

PMID: 27848393

 

One-year efficacy and safety of saxagliptin add-on in patients receiving dapagliflozin and metformin.

Matthaei S, Aggarwal N, Garcia-Hernandez P, Iqbal N, Chen H, Johnsson E, Chin A, Hansen L.

Diabetes Obes Metab. 2016 Nov;18(11):1128-1133. doi: 10.1111/dom.12741.

PMID: 27403645

 

Efficacy and safety of triple therapy with dapagliflozin add-on to saxagliptin plus metformin over 52 weeks in patients with type 2 diabetes.

Mathieu C, Herrera Marmolejo M, González González JG, Hansen L, Chen H, Johnsson E, Garcia-Sanchez R, Iqbal N.

Diabetes Obes Metab. 2016 Nov;18(11):1134-1137. doi: 10.1111/dom.12737.

PMID: 27385192

 

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.

Wang L, Collins C, Kelly EJ, Chu X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao M, Mathias A, Evers R, Humphreys W, Hop CE, Kumer SC, Unadkat JD.

Drug Metab Dispos. 2016 Nov;44(11):1752-1758.

PMID: 27543206

 

Non-cytochrome P450-mediated bioactivation and its toxicological relevance.

Gan J, Ma S, Zhang D.

Drug Metab Rev. 2016 Nov;48(4):473-501.

PMID: 27533622

 

Hepatitis C disease transmission and treatment uptake: impact on the cost-effectiveness of new direct-acting antiviral therapies.

Bennett H, Gordon J, Jones B, Ward T, Webster S, Kalsekar A, Yuan Y, Brenner M, McEwan P.

Eur J Health Econ. 2016 Nov 1. [Epub ahead of print]

PMID: 27803989

 

Systematic review of renal and bone safety of the antiretroviral regimen efavirenz, emtricitabine, and tenofovir disoproxil fumarate in patients with HIV infection.

Bedimo R, Rosenblatt L, Myers J.

HIV Clin Trials. 2016 Nov;17(6):246-266.

PMID: 27809711

 

Efficacy and safety of dapagliflozin in Asian patients with type 2 diabetes after metformin failure: A randomized controlled trial.

Yang W, Han P, Min KW, Wang B, Mansfield T, T'Joen C, Iqbal N, Johnsson E, Ptaszynska A.

J Diabetes. 2016 Nov;8(6):796-808. doi: 10.1111/1753-0407.12357.

PMID: 26589253

 

A phase 3, open-label study of daclatasvir plus asunaprevir in Asian patients with chronic hepatitis C virus genotype 1b infection who are ineligible for or intolerant to interferon alfa therapies with or without ribavirin.

Wei L, Zhang M, Xu M, Chuang WL, Lu W, Xie W, Jia Z, Gong G, Li Y, Bae SH, Yang YF, Xie Q, Lin S, Chen X, Niu J, Jia J, Garimella T, Torbeyns A, McPhee F, Treitel M, Yin PD, Mo L.

J Gastroenterol Hepatol. 2016 Nov;31(11):1860-1867. doi: 10.1111/jgh.13379.

PMID: 27003037

 

Mechanisms of Hyperbilirubinemia During Peginterferon Lambda-1a Therapy for Chronic Hepatitis C Infection: A Retrospective Investigation.

Zwirtes R, Narasimhan P, Wind-Rotolo MM, Xu D, Hruska MW, Kishnani N, Colston EM, Srinivasan S.

J Interferon Cytokine Res. 2016 Nov;36(11):644-651.

PMID: 27710263

 

Peginterferon Lambda-1a/Ribavirin with Daclatasvir or Peginterferon Alfa-2a/Ribavirin with Telaprevir for Chronic Hepatitis C Genotype 1b.

Flisiak R, Kawazoe S, Znoyko O, Assy N, Gadano A, Kao JH, Lee KS, Zwirtes R, Portsmouth S, Dong Y, Xu D, Kumada H, Srinivasan S.

J Interferon Cytokine Res. 2016 Nov;36(11):635-643.

PMID: 27327078

 

Cardiovascular Outcomes Associated with Lowering Low-density Lipoprotein Cholesterol in Rheumatoid Arthritis and Matched Nonrheumatoid Arthritis.

An J, Alemao E, Reynolds K, Kawabata H, Solomon DH, Liao KP, Niu F, Cheetham TC.

J Rheumatol. 2016 Nov;43(11):1989-1996.

PMID: 27585690

  

PS01.74: Systemic Treatment Sequencing in US Medicare Patients with Extensive Disease (ED)-Small Cell Lung Cancer (SCLC): Topic: Medical Oncology.

Danese M, Gleeson M, Lubeck D, Korytowsky B, Bobiak S.

J Thorac Oncol. 2016 Nov;11(11S):S317-S318. doi: 10.1016/j.jtho.2016.09.109. No abstract available.

PMID: 27969541

 

PS01.73: Have We Shifted the Therapeutic Innovation Frontier? A US Assessment of Advanced Non-Small Cell Lung Cancer (advNSCLC): Topic: Medical Oncology.

Korytowsky B, Justo N, Nilsson J, Madison T, Dalen J, McGuire A.

J Thorac Oncol. 2016 Nov;11(11S):S316-S317. doi: 10.1016/j.jtho.2016.09.108. No abstract available.

PMID: 27969540

 

PS01.59: CheckMate 370: A Master Protocol of Phase 1/2 Studies of Nivolumab as Maintenance or First-Line ± Standard-of-Care Therapies in Advanced NSCLC: Topic: Medical Oncology.

Blumenschein G Jr, Chandler J, Garon EB, Waterhouse D, Goldman JW, Gunuganti VK, Boccia R, Spigel D, Glaspy J, Berry DA, Korytowsky B, Zhu J, Lin WH, Bennett K, Reynolds C.

J Thorac Oncol. 2016 Nov;11(11S):S307. doi: 10.1016/j.jtho.2016.09.094. No abstract available.

PMID: 27969526

 

PS01.58: A Phase 3 Trial of Nivolumab, Nivolumab Plus Ipilimumab, or Placebo Maintenance for Extensive-Stage SCLC After First-Line Chemotherapy: Topic: Medical Oncology.

Owonikoko T, Ready N, Postmus P, Reck M, Peters S, Pieters A, Selvaggi G, Fairchild J, Govindan R.

J Thorac Oncol. 2016 Nov;11(11S):S306-S307. doi: 10.1016/j.jtho.2016.09.093. No abstract available.

PMID: 27969525

 

ORAL01.03: CheckMate 012: Safety and Efficacy of First-Line Nivolumab and Ipilimumab in Advanced NSCLC: Topic: Medical Oncology.

Antonia SJ, Gettinger SN, Goldman J, Brahmer J, Borghaei H, Chow LQ, Ready NE, Gerber DE, Juergens R, Shepherd F, Laurie SA, Young T, Geese WJ, Agrawal S, Li X, Hellmann MD.

J Thorac Oncol. 2016 Nov;11(11S):S250-S251. doi: 10.1016/j.jtho.2016.09.008. No abstract available.

PMID: 27969442

 

ORAL01.02: Biopsies in Initial Diagnosis of Non-Small Cell Lung Cancer in US Community Oncology Practices: Implications for First-Line Immunotherapy: Topic: Medical Oncology.

Hussein M, Richards DA, Ulrich B, Korytowsky B, Pandya D, Cogswell J, Batenchuk C, Burns V.

J Thorac Oncol. 2016 Nov;11(11S):S249-S250. doi: 10.1016/j.jtho.2016.09.007. No abstract available.

PMID: 27969441

 

Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial.

Sharma P, Callahan MK, Bono P, Kim J, Spiliopoulou P, Calvo E, Pillai RN, Ott PA, de Braud F, Morse M, Le DT, Jaeger D, Chan E, Harbison C, Lin CS, Tschaika M, Azrilevich A, Rosenberg JE.

Lancet Oncol. 2016 Nov;17(11):1590-1598. doi: 10.1016/S1470-2045(16)30496-X.

PMID: 27733243

 

Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial.

Hodi FS, Chesney J, Pavlick AC, Robert C, Grossmann KF, McDermott DF, Linette GP, Meyer N, Giguere JK, Agarwala SS, Shaheen M, Ernstoff MS, Minor DR, Salama AK, Taylor MH, Ott PA, Horak C, Gagnier P, Jiang J, Wolchok JD, Postow MA.

Lancet Oncol. 2016 Nov;17(11):1558-1568. doi: 10.1016/S1470-2045(16)30366-7.

PMID: 27622997

 

On-treatment HCV RNA as a predictor of sustained virological response in HCV genotype 3-infected patients treated with daclatasvir and sofosbuvir.

Kowdley KV, Nelson DR, Lalezari JP, Box T, Gitlin N, Poleynard G, Rabinovitz M, Ravendhran N, Sheikh AM, Siddique A, Bhore R, Noviello S, Rana K.

Liver Int. 2016 Nov;36(11):1611-1618. doi: 10.1111/liv.13165.

PMID: 27188960

 

Some practical considerations in three-arm non-inferiority trial design.

Zhou M, Kundu S.

Pharm Stat. 2016 Nov;15(6):550-559. doi: 10.1002/pst.1779.

PMID: 27681603

 

Autoxidation Products of Betulonaldehyde.

Ayers S, Benkovics T, Marshall J, Tan Y, Strotman NA, Kiau S.

J Nat Prod. 2016 Oct 28;79(10):2758-2761.

PMID: 27684353

 

Treatment Design and Rationale for a Randomized Trial of Cisplatin and Etoposide Plus Thoracic Radiotherapy Followed by Nivolumab or Placebo for Locally Advanced Non-Small-Cell Lung Cancer (RTOG 3505).

Gerber DE, Urbanic JJ, Langer C, Hu C, Chang IF, Lu B, Movsas B, Jeraj R, Curran WJ, Bradley JD.

Clin Lung Cancer. 2016 Oct 26. pii: S1525-7304(16)30352-7. doi: 10.1016/j.cllc.2016.10.009. [Epub ahead of print]

PMID: 27923550

 

Non-major bleeding with apixaban versus warfarin in patients with atrial fibrillation.

Bahit MC, Lopes RD, Wojdyla DM, Held C, Hanna M, Vinereanu D, Hylek EM, Verheugt F, Goto S, Alexander JH, Wallentin L, Granger CB.

Heart. 2016 Oct 24. pii: heartjnl-2016-309901. doi: 10.1136/heartjnl-2016-309901. [Epub ahead of print]

PMID: 27798052

 

Discovery of Highly Potent Liver X Receptor β Agonists.

Kick EK, Busch BB, Martin R, Stevens WC, Bollu V, Xie Y, Boren BC, Nyman MC, Nanao MH, Nguyen L, Plonowski A, Schulman IG, Yan G, Zhang H, Hou X, Valente MN, Narayanan R, Behnia K, Rodrigues AD, Brock B, Smalley J, Cantor GH, Lupisella J, Sleph P, Grimm D, Ostrowski J, Wexler RR, Kirchgessner T, Mohan R.

ACS Med Chem Lett. 2016 Oct 23;7(12):1207-1212.

PMID: 27994765

 

Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects.

Theunissen PT, Beken S, Beyer B, Breslin WJ, Cappon GD, Chen CL, Chmielewski G, de Schaepdrijver L, Enright B, Foreman JE, Harrouk W, Hew KW, Hoberman AM, Y Hui J, Knudsen TB, Laffan SB, Makris SL, Martin M, McNerney ME, Siezen CL, Stanislaus DJ, Stewart J, Thompson KE, Tornesi B, Van der Laan JW, Weinbauer GF, Wood S, Piersma AH.

Crit Rev Toxicol. 2016 Oct 21:1-13. [Epub ahead of print]

PMID: 27766926

 

Dual roles for regulatory T cell depletion and co-stimulatory signaling in agonistic GITR targeting for tumor immunotherapy.

Mahne A, Mauze S, Joyce-Shaikh B, Xia J, Bowman E, Beebe A, Cua D, Jain R.

Cancer Res. 2016 Oct 20. pii: canres.0797.2016. doi: 10.1158/0008-5472.CAN-16-0797. [Epub ahead of print]

PMID: 28122327

 

Results From an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody.

Segal NH, Logan TF, Hodi FS, McDermott DF, Melero I, Hamid O, Schmidt H, Robert C, Chiarion-Sileni V, Ascierto PA, Maio M, Urba WJ, Gangadhar TC, Suryawanshi S, Neely J, Jure-Kunkel M, Krishnan S, Kohrt HE, Sznol M, Levy R.

Clin Cancer Res. 2016 Oct 18. pii: clincanres.1272.2016. [Epub ahead of print]

PMID: 27756788

 

A Randomized Study of Peginterferon Lambda-1a Compared to Peginterferon Alfa-2a in Combination with Ribavirin and Telaprevir in Patients with Genotype-1 Chronic Hepatitis C.

Flisiak R, Shiffman M, Arenas J, Cheinquer H, Nikitin I, Dong Y, Rana K, Srinivasan S.

PLoS One. 2016 Oct 17;11(10):e0164563. doi: 10.1371/journal.pone.0164563.

PMID: 27749900

 

Regulatory Forum*: Progress toward ICH S1 Revision.

Peden WM.

Toxicol Pathol. 2016 Oct 17. pii: 0192623316673201. [Epub ahead of print]

PMID: 27753636

 

Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.

Ladziata VU, Glunz PW, Zou Y, Zhang X, Jiang W, Jacutin-Porte S, Cheney DL, Wei A, Luettgen JM, Harper TM, Wong PC, Seiffert D, Wexler RR, Priestley ES.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):5051-5057. doi: 10.1016/j.bmcl.2016.08.088.

PMID: 27612545

 

Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming.

Rodriguez-Ruiz ME, Rodriguez I, Garasa S, Barbes B, Solorzano JL, Perez-Gracia JL, Labiano S, Sanmamed MF, Azpilikueta A, Bolaños E, Sanchez-Paulete AR, Aznar MA, Rouzaut A, Schalper KA, Jure-Kunkel M, Melero I.

Cancer Res. 2016 Oct 15;76(20):5994-6005.

PMID: 27550452

 

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.

Watterson SH, De Lucca GV, Shi Q, Langevine CM, Liu Q, Batt DG, Beaudoin Bertrand M, Gong H, Dai J, Yip S, Li P, Sun D, Wu DR, Wang C, Zhang Y, Traeger SC, Pattoli MA, Skala S, Cheng L, Obermeier MT, Vickery R, Discenza LN, D'Arienzo CJ, Zhang Y, Heimrich E, Gillooly KM, Taylor TL, Pulicicchio C, McIntyre KW, Galella MA, Tebben AJ, Muckelbauer JK, Chang C, Rampulla R, Mathur A, Salter-Cid L, Barrish JC, Carter PH, Fura A, Burke JR, Tino JA.

J Med Chem. 2016 Oct 13;59(19):9173-9200.

PMID: 27583770

 

Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor.

Ahmad S, Washburn WN, Hernandez AS, Bisaha S, Ngu K, Wang W, Pelleymounter MA, Longhi D, Flynn N, Azzara AV, Rohrbach K, Devenny J, Rooney S, Thomas M, Glick S, Godonis H, Harvey S, Zhang H, Gemzik B, Janovitz EB, Huang C, Zhang L, Robl JA, Murphy BJ.

J Med Chem. 2016 Oct 13;59(19):8848-8858.

PMID: 27564419

 

Evaluation and selection of a non-PCR based technology for improved gene expression profiling from clinical formalin-fixed, paraffin-embedded samples.

Qi Z, Wang L, He A, Ma-Edmonds M, Cogswell J.

Bioanalysis. 2016 Oct 7. [Epub ahead of print]

PMID: 27712086

 

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV) (Part 1 - small molecules, peptides and small molecule biomarkers by LCMS).

Yang E, Welink J, Cape S, Woolf E, Sydor J, James C, Goykhman D, Arnold M, Addock N, Bauer R, Buonarati M, Ciccimaro E, Dodda R, Evans C, Garofolo F, Hughes N, Islam R, Nehls C, Wilson A, Briscoe C, Bustard M, Coppola L, Croft S, Drexler D, Ferrari L, Fraier D, Jenkins R, Kadavil J, King L, Li W, Lima Santos GM, Musuku A, Ramanathan R, Saito Y, Savoie N, Summerfield S, Sun R, Tampal N, Vinter S, Wakelin-Smith J, Yue Q.

Bioanalysis. 2016 Oct 7. [Epub ahead of print]

PMID: 27712081

 

Erratum to: Risk of cardiovascular events among patients with HIV treated with atazanavircontaining regimens: a retrospective cohort study.

Rosenblatt L, Farr AM, Nkhoma ET, Nelson JK, Ritchings C, Johnston SS.

BMC Infect Dis. 2016 Oct 7;16(1):547. No abstract available.

PMID: 27717332

 

The 'obesity paradox' in atrial fibrillation: observations from the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial.

Sandhu RK, Ezekowitz J, Andersson U, Alexander JH, Granger CB, Halvorsen S, Hanna M, Hijazi Z, Jansky P, Lopes RD, Wallentin L.

Eur Heart J. 2016 Oct 7;37(38):2869-2878.

PMID: 27071819

 

Synthesis of Fmoc-Protected Arylphenylalanines (Bip Derivatives) via Nonaqueous Suzuki-Miyaura Cross-Coupling Reactions.

Qiao JX, Fraunhoffer KJ, Hsiao Y, Li YX, Wang C, Wang TC, Poss MA.

J Org Chem. 2016 Oct 7;81(19):9499-9506.

PMID: 27615449

 

Novel platens to measure the hardness of a pentagonal shaped tablet.

Malladi J, Sidik K, Wu S, McCann R, Dougherty J, Parab P, Carragher T.

Pharm Dev Technol. 2016 Oct 4:1-10. [Epub ahead of print]

PMID: 27607150

 

Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators.

Hill MD, Fang H, Brown JM, Molski T, Easton A, Han X, Miller R, Hill-Drzewi M, Gallagher L, Matchett M, Gulianello M, Balakrishnan A, Bertekap RL, Santone KS, Whiterock VJ, Zhuo X, Bronson JJ, Macor JE, Degnan AP.

ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086.

PMID: 27994742

 

Recommendations to improve adverse event reporting in clinical trial publications: a joint pharmaceutical industry/journal editor perspective.

Lineberry N, Berlin JA, Mansi B, Glasser S, Berkwits M, Klem C, Bhattacharya A, Citrome L, Enck R, Fletcher J, Haller D, Chen TT, Laine C.

BMJ. 2016 Oct 3;355:i5078. doi: 10.1136/bmj.i5078. No abstract available.

PMID: 27697753

 

In-line ATR-UV and Raman Spectroscopy for Monitoring API Dissolution Process During Liquid-Filled Soft-Gelatin Capsule Manufacturing.

Wan B, Zordan CA, Lu X, McGeorge G.

AAPS PharmSciTech. 2016 Oct;17(5):1173-81. doi: 10.1208/s12249-015-0456-0.

PMID: 26604007

 

Establishing a complementary diagnostic for anti-PD-1 immune checkpoint inhibitor therapy.

Novotny JF Jr, Cogswell J, Inzunza H, Harbison C, Horak C, Averbuch S.

Ann Oncol. 2016 Oct;27(10):1966-9. doi: 10.1093/annonc/mdw288. No abstract available.

PMID: 27502705

 

Effect of nivolumab on health-related quality of life in patients with treatment-naïve advanced melanoma: results from the phase III CheckMate 066 study.

Long GV, Atkinson V, Ascierto PA, Robert C, Hassel JC, Rutkowski P, Savage KJ, Taylor F, Coon C, Gilloteau I, Dastani HB, Waxman IM, Abernethy AP.

Ann Oncol. 2016 Oct;27(10):1940-6. doi: 10.1093/annonc/mdw265.

PMID: 27405322

 

Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results from the APPRAISE study.

D'Agostino MA, Wakefield RJ, Berner-Hammer H, Vittecoq O, Filippou G, Balint P, Möller I, Iagnocco A, Naredo E, Østergaard M, Boers M, Gaillez C, Van Holder K, Le Bars M; OMERACT-EULAR-Ultrasound Task Force..

Ann Rheum Dis. 2016 Oct;75(10):1763-9. doi: 10.1136/annrheumdis-2015-207709.

PMID: 26590174

 

A validated LC-MS/MS method for the quantitative measurement of creatinine as an endogenous biomarker in human plasma.

Zhao Y, Liu G, Angeles A, Christopher LJ, Wang Z, Arnold ME, Shen JX.

Bioanalysis. 2016 Oct;8(19):1997-2005. doi: 10.4155/bio-2016-0086.

PMID: 27611058

 

HCV NS5A replication complex inhibitors.

Gao M, O'Boyle DR 2nd, Roberts S.

Curr Opin Pharmacol. 2016 Oct;30:151-157. doi: 10.1016/j.coph.2016.07.014. Review.

PMID: 27643675

 

Efficacy and Safety of Multiple Doses of Exenatide Once-Monthly Suspension in Patients With Type 2 Diabetes: A Phase II Randomized Clinical Trial.

Wysham CH, MacConell L, Hardy E.

Diabetes Care. 2016 Oct;39(10):1768-76. doi: 10.2337/dc16-0238.

PMID: 27436275

 

Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective.

Fahmi OA, Shebley M, Palamanda J, Sinz MW, Ramsden D, Einolf HJ, Chen L, Wang H.

Drug Metab Dispos. 2016 Oct;44(10):1720-30. doi: 10.1124/dmd.116.071076.

PMID: 27422672

 

Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa.

Schmidt A, Hammerbacher AS, Bastian M, Nieken KJ, Klockgether J, Merighi M, Lapouge K, Poschgan C, Kölle J, Acharya KR, Ulrich M, Tümmler B, Unden G, Kaever V, Lory S, Haas D, Schwarz S, Döring G.

Environ Microbiol. 2016 Oct;18(10):3390-3402. doi: 10.1111/1462-2920.13208.

PMID: 26743546

 

Novel statistical approach for evaluating flow cytometric in vitro micronucleus data.

Wojciechowski JP, Gleason CR, Roberts DJ, Custer LL.

Environ Mol Mutagen. 2016 Oct;57(8):623-629. doi: 10.1002/em.22038.

PMID: 27545269

 

P2.46 (also presented as PD1.01): LCSS as a Marker of Treatment Benefit With Nivolumab vs Docetaxel in Pts With Advanced Non-Squamous NSCLC From Checkmate 057: Track: Immunotherapy.

Gralla RJ, Spigel D, Bennett B, Taylor F, Penrod JR, Derosa M, Dastani H, Orsini L, Mathias C, Reck M.

J Thorac Oncol. 2016 Oct;11(10S):S247. doi: 10.1016/j.jtho.2016.08.117. No abstract available.

PMID: 27676580

 

P2.36: Nivolumab (nivo) in Patients (pts) With Advanced (adv) NSCLC and Central Nervous System (CNS) Metastases (mets): Track: Immunotherapy.

Goldman JW, Crino L, Vokes EE, Holgado E, Reckamp K, Pluzanski A, Spigel D, Kohlhaeufl M, Garassino M, Chow LQ, Gettinger S, Gerber DE, Havel L, Ramalingam SS, Dy GK, Geese WJ, Li A, Blackwood-Chirchir A, Healey D, Brahmer J, Lopes G.

J Thorac Oncol. 2016 Oct;11(10S):S238-S239. doi: 10.1016/j.jtho.2016.08.107. No abstract available.

PMID: 27676570

 

P2.35: Nivolumab vs Docetaxel in Advanced NSCLC: CheckMate 017/057 2-Y Update and Exploratory Cytokine Profile Analysis: Track: Immunotherapy.

Borghaei H, Brahmer J, Horn L, Ready N, Steins M, Felip E, Paz-Ares L, Xx X, Barlesi F, Antonia S, Fayette J, Rizvi N, Crino L, Reck M, Erich Eberhardt WE, Hellmann M, Desai K, Li A, Healey D, Spigel D, Mathias C.

J Thorac Oncol. 2016 Oct;11(10S):S237-S238. doi: 10.1016/j.jtho.2016.08.106. No abstract available.

PMID: 27676569

 

P2.33: Safety Profile of Nivolumab Administered as 30-Minute (MIN) Infusion: Analysis of Data From Checkmate 153: Track: Immunotherapy.

Waterhouse D, Horn L, Reynolds C, Spigel D, Chandler J, Mekhail T, Mohamed M, Creelan B, Blankstein KB, Nikolinakos P, Mccleod MJ, Li A, Waxman IM, Aanur N, Agrawal S, Richardet E.

J Thorac Oncol. 2016 Oct;11(10S):S236. doi: 10.1016/j.jtho.2016.08.104. No abstract available.

PMID: 27676567

 

PD1.01 (also presented as P2.46): LCSS as a Marker of Treatment Benefit With Nivolumab vs Docetaxel in Pts With Advanced Non-Squamous NSCLC From Checkmate 057.

Gralla RJ, Spigel D, Bennett B, Taylor F, Penrod JR, Derosa M, Dastani H, Orsini L, Mathias C, Reck M.

J Thorac Oncol. 2016 Oct;11(10S):S171. doi: 10.1016/j.jtho.2016.08.009. No abstract available.

PMID: 27676476

  

All-oral daclatasvir plus asunaprevir for chronic hepatitis C virus (HCV) genotype 1b infection: a sub-analysis in Asian patients from the HALLMARK DUAL study.

Kao JH, Lee YJ, Heo J, Ahn SH, Lim YS, Peng CY, Chang TT, Torbeyns A, Hughes E, Bhore R, Noviello S.

Liver Int. 2016 Oct;36(10):1433-41. doi: 10.1111/liv.13128.

PMID: 27009831

 

Investigating investment in biopharmaceutical R&D.

Carter PH, Berndt ER, DiMasi JA, Trusheim M.

Nat Rev Drug Discov. 2016 Oct;15(10):673-4. doi: 10.1038/nrd.2016.104. No abstract available.

PMID: 27616295

 

Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction.

Chen Y, Wang S, Wang S, Liu C, Su C, Hageman M, Hussain M, Haskell R, Stefanski K, Qian F.

Pharm Res. 2016 Oct;33(10):2445-58. doi: 10.1007/s11095-016-1969-2.

PMID: 27283830

 

Effects of BMS-986094, a Guanosine Nucleotide Analogue, on Mitochondrial DNA Synthesis and Function.

Baumgart BR, Wang F, Kwagh J, Storck C, Euler C, Fuller M, Simic D, Sharma S, Arnold JJ, Cameron CE, Van Vleet TR, Flint O, Bunch RT, Davies MH, Graziano MJ, Sanderson TP.

Toxicol Sci. 2016 Oct;153(2):396-408. doi: 10.1093/toxsci/kfw135.

PMID: 27466212

 

Mixtures, Metabolites, and Mechanisms: Understanding Toxicology Using Zebrafish.

Gamse JT, Gorelick DA.

Zebrafish. 2016 Oct;13(5):377-8. doi: 10.1089/zeb.2016.1370.

PMID: 27618129

 

Early real-world evidence of persistence on oral anticoagulants for stroke prevention in non-valvular atrial fibrillation: a cohort study in UK primary care.

Johnson ME, Lefèvre C, Collings SL, Evans D, Kloss S, Ridha E, Maguire A.

BMJ Open. 2016 Sep 26;6(9):e011471. doi: 10.1136/bmjopen-2016-011471.

PMID: 27678530

 

 Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.

Wu YJ, Guernon J, Shi J, Marcin L, Higgins M, Rajamani R, Muckelbauer J, Lewis H, Chang C, Camac D, Toyn JH, Ahlijanian MK, Albright CF, Macor JE, Thompson LA.

J Med Chem. 2016 Sep 22;59(18):8593-600. doi: 10.1021/acs.jmedchem.6b01012.

PMID: 27559936

 

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).

Engers DW, Blobaum AL, Gogliotti RD, Cheung YY, Salovich JM, Garcia-Barrantes PM, Daniels JS, Morrison R, Jones CK, Soars MG, Zhuo X, Hurley J, Macor JE, Bronson JJ, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.

ACS Chem Neurosci. 2016 Sep 21;7(9):1192-200. doi: 10.1021/acschemneuro.6b00035.

PMID: 27075300

 

Population pharmacokinetics of exenatide.

Cirincione B, Mager DE.

Br J Clin Pharmacol. 2016 Sep 21. doi: 10.1111/bcp.13135. [Epub ahead of print]

PMID: 27650681

 

Risk of cardiovascular events among patients with HIV treated with atazanavir-containing regimens: a retrospective cohort study.

Rosenblatt L, Farr AM, Nkhoma ET, Nelson JK, Ritchings C, Johnston SS.

BMC Infect Dis. 2016 Sep 19;16:492. doi: 10.1186/s12879-016-1827-1. Erratum in: BMC Infect Dis. 2016 Oct 7;16(1):547.

PMID: 27643691

 

 Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors.

Wurtz NR, Parkhurst BL, Jiang W, DeLucca I, Zhang X, Ladziata V, Cheney DL, Bozarth JR, Rendina AR, Wei A, Luettgen JM, Wu Y, Wong PC, Seiffert DA, Wexler RR, Priestley ES.

ACS Med Chem Lett. 2016 Sep 17;7(12):1077-1081.

PMID: 27994741

 

Overview of Critical Parameters for the Design and Execution of a High-Throughput Screen for Allosteric Ligands.

Alt A.

Curr Protoc Pharmacol. 2016 Sep 16;74:9.20.1-9.20.23. doi: 10.1002/cpph.12.

PMID: 27636112

 

Bioequivalence and food effect of heat-stressed and non-heat-stressed dapagliflozin 2.5- and 10-mg tablets.

LaCreta F, Griffen SC, Liu X, Smith C, Hines C, Volk K, Tejwani R, Boulton DW.

Int J Pharm. 2016 Sep 10;511(1):288-95. doi: 10.1016/j.ijpharm.2016.07.017.

PMID: 27418571

 

An integrated approach for profiling oxidative metabolites and glutathione adducts using liquid chromatography coupled with ultraviolet detection and triple quadrupole-linear ion trap mass spectrometry.

Chen G, Cheng Z, Zhang K, Jiang H, Zhu M.

J Pharm Biomed Anal. 2016 Sep 10;129:482-91. doi: 10.1016/j.jpba.2016.07.048.

PMID: 27497649

 

Definitive Upfront Stereotactic Ablative Radiotherapy Combined with Image-Guided, Intensity Modulated Radiotherapy (IG-IMRT) or IG-IMRT Alone for Locally Advanced Non-Small Cell Lung Cancer.

Chi A, Wen S, Monga M, Almubarak M, He X, Rojanasakul Y, Tse W, Remick SC.

PLoS One. 2016 Sep 9;11(9):e0162453. doi: 10.1371/journal.pone.0162453.

PMID: 27611833

 

Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.

Selby MJ, Engelhardt JJ, Johnston RJ, Lu LS, Han M, Thudium K, Yao D, Quigley M, Valle J, Wang C, Chen B, Cardarelli PM, Blanset D, Korman AJ.

PLoS One. 2016 Sep 9;11(9):e0161779. doi: 10.1371/journal.pone.0161779. Erratum in: PLoS One. 2016 Nov 18;11(11):e0167251.

PMID: 27610613

 

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.

Sun LQ, Mull E, Zheng B, D'Andrea S, Zhao Q, Wang AX, Sin N, Venables BL, Sit SY, Chen Y, Chen J, Cocuzza A, Bilder DM, Mathur A, Rampulla R, Chen BC, Palani T, Ganesan S, Arunachalam PN, Falk P, Levine S, Chen C, Friborg J, Yu F, Hernandez D, Sheaffer AK, Knipe JO, Han YH, Schartman R, Donoso M, Mosure K, Sinz MW, Zvyaga T, Rajamani R, Kish K, Tredup J, Klei HE, Gao Q, Ng A, Mueller L, Grasela DM, Adams S, Loy J, Levesque PC, Sun H, Shi H, Sun L, Warner W, Li D, Zhu J, Wang YK, Fang H, Cockett MI, Meanwell NA, McPhee F, Scola PM.

J Med Chem. 2016 Sep 8;59(17):8042-60. doi: 10.1021/acs.jmedchem.6b00821.

PMID: 27564532

 

Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).

De Lucca GV, Shi Q, Liu Q, Batt DG, Beaudoin Bertrand M, Rampulla R, Mathur A, Discenza L, D'Arienzo C, Dai J, Obermeier M, Vickery R, Zhang Y, Yang Z, Marathe P, Tebben AJ, Muckelbauer JK, Chang CJ, Zhang H, Gillooly K, Taylor T, Pattoli MA, Skala S, Kukral DW, McIntyre KW, Salter-Cid L, Fura A, Burke JR, Barrish JC, Carter PH, Tino JA.

J Med Chem. 2016 Sep 8;59(17):7915-35. doi: 10.1021/acs.jmedchem.6b00722.

PMID: 27531604

 

Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort.

Welzel TM, Petersen J, Herzer K, Ferenci P, Gschwantler M, Wedemeyer H, Berg T, Spengler U, Weiland O, van der Valk M, Rockstroh J, Peck-Radosavljevic M, Zhao Y, Jimenez-Exposito MJ, Zeuzem S.

Gut. 2016 Sep 7. pii: gutjnl-2016-312444. doi: 10.1136/gutjnl-2016-312444. [Epub ahead of print] Erratum in: Gut. 2016 Dec;65(12 ):2060.

PMID: 27605539

 

Redox-Active Esters in Fe-Catalyzed C-C Coupling.

Toriyama F, Cornella J, Wimmer L, Chen TG, Dixon DD, Creech G, Baran PS.

J Am Chem Soc. 2016 Sep 7;138(35):11132-5. doi: 10.1021/jacs.6b07172.

PMID: 27548696

 

Implementation of USP antibody standard for system suitability in capillary electrophoresis sodium dodecyl sulfate (CE-SDS) for release and stability methods.

Esterman AL, Katiyar A, Krishnamurthy G.

J Pharm Biomed Anal. 2016 Sep 5;128:447-54. doi: 10.1016/j.jpba.2016.06.006.

PMID: 27344634

 

Characterization of human metabolism and disposition of levo-tetrahydropalmatine: Qualitative and quantitative determination of oxidative and conjugated metabolites.

Xiao W, Shen G, Zhuang X, Ran X, Zhu M, Li H.

J Pharm Biomed Anal. 2016 Sep 5;128:371-81. doi: 10.1016/j.jpba.2016.06.015.

PMID: 27343900

 

Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity.

Aubry AF, Dean B, Diczfalusy U, Goodenough A, Iffland A, McLeod J, Weng N, Yang Z.

AAPS J. 2016 Sep;18(5):1056-66. doi: 10.1208/s12248-016-9949-3. Review.

PMID: 27350147

 

Preclinical to Clinical Translation of Antibody-Drug Conjugates Using PK/PD Modeling: a Retrospective Analysis of Inotuzumab Ozogamicin.

Betts AM, Haddish-Berhane N, Tolsma J, Jasper P, King LE, Sun Y, Chakrapani S, Shor B, Boni J, Johnson TR.

AAPS J. 2016 Sep;18(5):1101-16. doi: 10.1208/s12248-016-9929-7.

PMID: 27198897

 

Tissue distribution and tumor uptake of folate receptor-targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration.

Shen H, Wang L, Chen W, Menard K, Hong Y, Tian Y, Bonacorsi SJ, Humphreys WG, Lee FY, Gan J.

Acta Pharm Sin B. 2016 Sep;6(5):460-467.

PMID: 27709015

 

Apixaban compared with parenteral heparin and/or vitamin K antagonist in patients with nonvalvular atrial fibrillation undergoing cardioversion: Rationale and design of the EMANATE trial.

Ezekowitz MD, Pollack CV, Sanders P, Halperin JL, Spahr J, Cater N, Petkun W, Breazna A, Kirchhof P, Oldgren J.

Am Heart J. 2016 Sep;179:59-68. doi: 10.1016/j.ahj.2016.06.008.

PMID: 27595680

 

Dasatinib in imatinib-resistant or -intolerant chronic-phase, chronic myeloid leukemia patients: 7-year follow-up of study CA180-034.

Shah NP, Rousselot P, Schiffer C, Rea D, Cortes JE, Milone J, Mohamed H, Healey D, Kantarjian H, Hochhaus A, Saglio G.

Am J Hematol. 2016 Sep;91(9):869-74. doi: 10.1002/ajh.24423.

PMID: 27192969

 

Brief Report: Estimating Disease Activity Using Multi-Biomarker Disease Activity Scores in Rheumatoid Arthritis Patients Treated With Abatacept or Adalimumab.

Fleischmann R, Connolly SE, Maldonado MA, Schiff M.

Arthritis Rheumatol. 2016 Sep;68(9):2083-9. doi: 10.1002/art.39714.

PMID: 27111089

 

The Efficacy and Safety of Clazakizumab, an Anti-Interleukin-6 Monoclonal Antibody, in a Phase IIb Study of Adults With Active Psoriatic Arthritis.

Mease PJ, Gottlieb AB, Berman A, Drescher E, Xing J, Wong R, Banerjee S.

Arthritis Rheumatol. 2016 Sep;68(9):2163-73. doi: 10.1002/art.39700.

PMID: 27059799

 

A simple, effective approach for rapid development of high-throughput and reliable LC-MS/MS bioanalytical assays.

Yuan L, Aubry AF, Ji QC.

Bioanalysis. 2016 Sep;8(17):1809-22. doi: 10.4155/bio-2016-0100.

PMID: 27491843

 

Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.

Huang H, Degnan AP, Balakrishnan A, Easton A, Gulianello M, Huang Y, Matchett M, Mattson G, Miller R, Santone KS, Senapati A, Shields EE, Sivarao DV, Snyder LB, Westphal R, Whiterock VJ, Yang F, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2016 Sep 1;26(17):4165-9. doi: 10.1016/j.bmcl.2016.07.065.

PMID: 27496211

 

Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.

Bhide RS, Neels J, Qin LY, Ruan Z, Stachura S, Weigelt C, Sack JS, Stefanski K, Gu X, Xie JH, Goldstine CB, Skala S, Pedicord DL, Ruepp S, Dhar TG, Carter PH, Salter-Cid LM, Poss MA, Davies P.

Bioorg Med Chem Lett. 2016 Sep 1;26(17):4256-60. doi: 10.1016/j.bmcl.2016.07.047.

PMID: 27476421

 

CHO cells knocked out for TSC2 display an improved productivity of antibodies under fed batch conditions.

McVey D, Aronov M, Rizzi G, Cowan A, Scott C, Megill J, Russell R, Tirosh B.

Biotechnol Bioeng. 2016 Sep;113(9):1942-52. doi: 10.1002/bit.25951.

PMID: 26888596

 

Combined metabolomics and proteomics reveals hypoxia as a cause of lower productivity on scale-up to a 5000-liter CHO bioprocess.

Gao Y, Ray S, Dai S, Ivanov AR, Abu-Absi NR, Lewis AM, Huang Z, Xing Z, Borys MC, Li ZJ, Karger BL.

Biotechnol J. 2016 Sep;11(9):1190-200. doi: 10.1002/biot.201600030.

PMID: 27213298

 

Large Cell Neuroendocrine Carcinoma of the Lung: Clinico-Pathologic Features, Treatment, and Outcomes.

Naidoo J, Santos-Zabala ML, Iyriboz T, Woo KM, Sima CS, Fiore JJ, Kris MG, Riely GJ, Lito P, Iqbal A, Veach S, Smith-Marrone S, Sarkaria IS, Krug LM, Rudin CM, Travis WD, Rekhtman N, Pietanza MC.

Clin Lung Cancer. 2016 Sep;17(5):e121-e129. doi: 10.1016/j.cllc.2016.01.003.

PMID: 26898325

 

A practical approach for the scale-up of roller compaction process.

Shi W, Sprockel OL.

Eur J Pharm Biopharm. 2016 Sep;106:15-9. doi: 10.1016/j.ejpb.2016.02.005.

PMID: 26883853

 

 Daclatasvir/peginterferon lambda-1a/ribavirin in patients with chronic HCV infection and haemophilia who are treatment naïve or prior relapsers to peginterferon alfa-2a/ribavirin.

Santagostino E, Pol S, Olveira A, Reesink HW, van Erpecum K, Bogomolov P, Xu D, Critelli L, Srinivasan S, Cooney E.

Haemophilia. 2016 Sep;22(5):692-9. doi: 10.1111/hae.12947.

PMID: 27339614

 

Entecavir plus tenofovir combination therapy for chronic hepatitis B in patients with previous nucleos(t)ide treatment failure.

Zoulim F, Białkowska-Warzecha J, Diculescu MM, Goldis AE, Heyne R, Mach T, Marcellin P, Petersen J, Simon K, Bendahmane S, Klauck I, Wasiak W, Janssen HL.

Hepatol Int. 2016 Sep;10(5):779-88. doi: 10.1007/s12072-016-9737-2.

PMID: 27206517

 

Major bleeding risk among non-valvular atrial fibrillation patients initiated on apixaban, dabigatran, rivaroxaban or warfarin: a "real-world" observational study in the United States.

Lip GY, Pan X, Kamble S, Kawabata H, Mardekian J, Masseria C, Bruno A, Phatak H.

Int J Clin Pract. 2016 Sep;70(9):752-63. doi: 10.1111/ijcp.12863.

PMID: 27550177

 

 Effect of rate of pyrolysis on the textural properties of naturally-templated porous carbons from alginic acid.

Marriott AS, Hunt AJ, Bergström E, Thomas-Oates J, Clark JH.

J Anal Appl Pyrolysis. 2016 Sep;121:62-66.

PMID: 27695151

 

Development of a Human Whole Blood Screening Platform to Monitor JAK/STAT Signaling Using High-Throughput Flow Cytometry.

Fereshteh MP, Li X, Li S, Fan Y, Zhang R, Farr GA, Kolodin G, Lippy J, Naglich JG, Schieven G, Schweizer L, Zhang L.

J Biomol Screen. 2016 Sep;21(8):866-74. doi: 10.1177/1087057116645095.

PMID: 27142718

 

Nivolumab Monotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer.

Gettinger S, Rizvi NA, Chow LQ, Borghaei H, Brahmer J, Ready N, Gerber DE, Shepherd FA, Antonia S, Goldman JW, Juergens RA, Laurie SA, Nathan FE, Shen Y, Harbison CT, Hellmann MD.

J Clin Oncol. 2016 Sep 1;34(25):2980-7. doi: 10.1200/JCO.2016.66.9929.

PMID: 27354485

 

Nivolumab in Combination With Platinum-Based Doublet Chemotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer.

Rizvi NA, Hellmann MD, Brahmer JR, Juergens RA, Borghaei H, Gettinger S, Chow LQ, Gerber DE, Laurie SA, Goldman JW, Shepherd FA, Chen AC, Shen Y, Nathan FE, Harbison CT, Antonia S.

J Clin Oncol. 2016 Sep 1;34(25):2969-79. doi: 10.1200/JCO.2016.66.9861.

PMID: 27354481

 

Current Challenges and Potential Opportunities for the Pharmaceutical Sciences to Make Global Impact: An FIP Perspective.

Tucker G, DeSilva B, Dressman J, Ito M, Kumamoto T, Mager D, Mahler HC, Maitland-van der Zee AH, Pauletti GM, Sasaki H, Shah V, Tang D, Ward M.

J Pharm Sci. 2016 Sep;105(9):2489-97. doi: 10.1016/j.xphs.2015.12.001.

PMID: 26886325

 

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.

Kostich W, Hamman BD, Li YW, Naidu S, Dandapani K, Feng J, Easton A, Bourin C, Baker K, Allen J, Savelieva K, Louis JV, Dokania M, Elavazhagan S, Vattikundala P, Sharma V, Das ML, Shankar G, Kumar A, Holenarsipur VK, Gulianello M, Molski T, Brown JM, Lewis M, Huang Y, Lu Y, Pieschl R, O'Malley K, Lippy J, Nouraldeen A, Lanthorn TH, Ye G, Wilson A, Balakrishnan A, Denton R, Grace JE, Lentz KA, Santone KS, Bi Y, Main A, Swaffield J, Carson K, Mandlekar S, Vikramadithyan RK, Nara SJ, Dzierba C, Bronson J, Macor JE, Zaczek R, Westphal R, Kiss L, Bristow L, Conway CM, Zambrowicz B, Albright CF.

J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. doi: 10.1124/jpet.116.235333.

PMID: 27411717

 

Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition.

Lai Y, Mandlekar S, Shen H, Holenarsipur VK, Langish R, Rajanna P, Murugesan S, Gaud N, Selvam S, Date O, Cheng Y, Shipkova P, Dai J, Humphreys WG, Marathe P.

J Pharmacol Exp Ther. 2016 Sep;358(3):397-404. doi: 10.1124/jpet.116.234914.

PMID: 27317801

 

Apixaban 5 mg Twice Daily and Clinical Outcomes in Patients With Atrial Fibrillation and Advanced Age, Low Body Weight, or High Creatinine: A Secondary Analysis of a Randomized Clinical Trial.

Alexander JH, Andersson U, Lopes RD, Hijazi Z, Hohnloser SH, Ezekowitz JA, Halvorsen S, Hanna M, Commerford P, Ruzyllo W, Huber K, Al-Khatib SM, Granger CB, Wallentin L; Apixaban for Reduction of Stroke and Other Thromboembolic Complications in Atrial Fibrillation (ARISTOTLE) Investigators..

JAMA Cardiol. 2016 Sep 1;1(6):673-81. doi: 10.1001/jamacardio.2016.1829.

PMID: 27463942

 

Safety and Efficacy of Nivolumab in Patients With Metastatic Renal Cell Carcinoma Treated Beyond Progression: A Subgroup Analysis of a Randomized Clinical Trial.

George S, Motzer RJ, Hammers HJ, Redman BG, Kuzel TM, Tykodi SS, Plimack ER, Jiang J, Waxman IM, Rini BI.

JAMA Oncol. 2016 Sep 1;2(9):1179-86. doi: 10.1001/jamaoncol.2016.0775.

PMID: 27243803

 

Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial.

Younes A, Santoro A, Shipp M, Zinzani PL, Timmerman JM, Ansell S, Armand P, Fanale M, Ratanatharathorn V, Kuruvilla J, Cohen JB, Collins G, Savage KJ, Trneny M, Kato K, Farsaci B, Parker SM, Rodig S, Roemer MG, Ligon AH, Engert A.

Lancet Oncol. 2016 Sep;17(9):1283-94. doi: 10.1016/S1470-2045(16)30167-X.

PMID: 27451390

 

Bioanalysis of dried saliva spot (DSS) samples using detergent-assisted sample extraction with UHPLC-MS/MS detection.

Zheng N, Zeng J, Ji QC, Angeles A, Aubry AF, Basdeo S, Buzescu A, Landry IS, Jariwala N, Turley W, Burrell R, Arnold ME.

Anal Chim Acta. 2016 Aug 31;934:170-9. doi: 10.1016/j.aca.2016.05.057.

PMID: 27506357

 

Harmonizing Global Biospecimen Consent Practices to Advance Translational Research: A Call to Action.

Warner AW, Moore H, Reinhard D, Ball LA, Knoppers BM.

Clin Pharmacol Ther. 2016 Aug 25. doi: 10.1002/cpt.461. [Epub ahead of print]

PMID: 27558027

 

Evaluation of Immunogenicity of Nivolumab Monotherapy and Its Clinical Relevance in Patients With Metastatic Solid Tumors.

Agrawal S, Statkevich P, Bajaj G, Feng Y, Saeger S, Desai DD, Park JS, Waxman IM, Roy A, Gupta M.

J Clin Pharmacol. 2016 Aug 25. doi: 10.1002/jcph.818. [Epub ahead of print]

PMID: 27557786

 

2015 Philip S. Portoghese Medicinal Chemistry Lectureship. Curing Hepatitis C Virus Infection with Direct-Acting Antiviral Agents: The Arc of a Medicinal Chemistry Triumph.

Meanwell NA.

J Med Chem. 2016 Aug 25;59(16):7311-51. doi: 10.1021/acs.jmedchem.6b00915.

PMID: 27501244

 

IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.

Singh B, Jegga AG, Shanmukhappa KS, Edukulla R, Khurana GH, Medvedovic M, Dillon SR, Madala SK.

PLoS One. 2016 Aug 24;11(8):e0161877. doi: 10.1371/journal.pone.0161877. Erratum in: PLoS One. 2017 Jan 23;12 (1):e0170446.

PMID: 27556734

 

Application of X-ray microtomography for the characterisation of hollow polymer-stabilised spray dried amorphous dispersion particles.

Gamble JF, Terada M, Holzner C, Lavery L, Nicholson SJ, Timmins P, Tobyn M.

Int J Pharm. 2016 Aug 20;510(1):1-8. doi: 10.1016/j.ijpharm.2016.05.051.

PMID: 27262271

  

Insights in understanding aggregate formation and dissociation in cation exchange chromatography for a structurally unstable Fc-fusion protein.

Chen Z, Huang C, Chennamsetty N, Xu X, Li ZJ.

J Chromatogr A. 2016 Aug 19;1460:110-22. doi: 10.1016/j.chroma.2016.07.023.

PMID: 27452990

 

A randomized, controlled study of peginterferon lambda-1a/ribavirin ± daclatasvir for hepatitis C virus genotype 2 or 3.

Foster GR, Chayama K, Chuang WL, Fainboim H, Farkkila M, Gadano A, Gaeta GB, Hézode C, Inada Y, Heo J, Kumada H, Lu SN, Marcellin P, Moreno C, Roberts SK, Strasser SI, Thompson AJ, Toyota J, Paik SW, Vierling JM, Zignego AL, Cohen D, McPhee F, Wind-Rotolo M, Srinivasan S, Hruska M, Myler H, Portsmouth SD.

Springerplus. 2016 Aug 19;5(1):1365. doi: 10.1186/s40064-016-2920-z.

PMID: 27588258

 

Phase II study of vemurafenib followed by ipilimumab in patients with previously untreated BRAF-mutated metastatic melanoma.

Amin A, Lawson DH, Salama AK, Koon HB, Guthrie T Jr, Thomas SS, O'Day SJ, Shaheen MF, Zhang B, Francis S, Hodi FS.

J Immunother Cancer. 2016 Aug 16;4:44. doi: 10.1186/s40425-016-0148-7.

PMID: 27532019

 

Predictive ability of HAS-BLED, HEMORR2HAGES, and ATRIA bleeding risk scores in patients with atrial fibrillation. A French nationwide cross-sectional study.

Fauchier L, Chaize G, Gaudin AF, Vainchtock A, Rushton-Smith SK, Cotté FE.

Int J Cardiol. 2016 Aug 15;217:85-91. doi: 10.1016/j.ijcard.2016.04.173.

PMID: 27179213

 

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.

Huang RY, Iacob RE, Krystek SR, Jin M, Wei H, Tao L, Das TK, Tymiak AA, Engen JR, Chen G.

J Am Soc Mass Spectrom. 2016 Aug 15. [Epub ahead of print]

PMID: 27527097

 

Development of a high-throughput mass spectrometry based analytical method to support an in vitro OATP1B1 inhibition screening assay.

Wagner AD, Elkin L, Mosure K, Gallagher L, Stavola LK, Soars MG, Shou W.

Rapid Commun Mass Spectrom. 2016 Aug 15;30(15):1787-96. doi: 10.1002/rcm.7655.

PMID: 27426455

 

Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex.

Zhang X, Glunz PW, Johnson JA, Jiang W, Jacutin-Porte S, Ladziata V, Zou Y, Phillips MS, Wurtz NR, Parkhurst B, Rendina AR, Harper TM, Cheney DL, Luettgen JM, Wong PC, Seiffert D, Wexler RR, Priestley ES.

J Med Chem. 2016 Aug 11;59(15):7125-37. doi: 10.1021/acs.jmedchem.6b00469.

PMID: 27455395

 

Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study.

Lesokhin AM, Ansell SM, Armand P, Scott EC, Halwani A, Gutierrez M, Millenson MM, Cohen AD, Schuster SJ, Lebovic D, Dhodapkar M, Avigan D, Chapuy B, Ligon AH, Freeman GJ, Rodig SJ, Cattry D, Zhu L, Grosso JF, Bradley Garelik MB, Shipp MA, Borrello I, Timmerman J.

J Clin Oncol. 2016 Aug 10;34(23):2698-704. doi: 10.1200/JCO.2015.65.9789.

PMID: 27269947

 

Serum microRNAs-217 and -375 as biomarkers of acute pancreatic injury in rats.

Calvano J, Edwards G, Hixson C, Burr H, Mangipudy R, Tirmenstein M.

Toxicology. 2016 Aug 10;368-369:1-9. doi: 10.1016/j.tox.2016.08.009.

PMID: 27521901

 

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study., Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ.

Cell Metab. 2016 Aug 9;24(2):234-45. doi: 10.1016/j.cmet.2016.07.012.

PMID: 27508872

 

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils.

Kirchgessner TG, Sleph P, Ostrowski J, Lupisella J, Ryan CS, Liu X, Fernando G, Grimm D, Shipkova P, Zhang R, Garcia R, Zhu J, He A, Malone H, Martin R, Behnia K, Wang Z, Barrett YC, Garmise RJ, Yuan L, Zhang J, Gandhi MD, Wastall P, Li T, Du S, Salvador L, Mohan R, Cantor GH, Kick E, Lee J, Frost RJ.

Cell Metab. 2016 Aug 9;24(2):223-33. doi: 10.1016/j.cmet.2016.07.016.

PMID: 27508871

 

Daclatasvir/asunaprevir/beclabuvir fixed-dose combination in Japanese patients with HCV genotype 1 infection.

Toyota J, Karino Y, Suzuki F, Ikeda F, Ido A, Tanaka K, Takaguchi K, Naganuma A, Tomita E, Chayama K, Fujiyama S, Inada Y, Yoshiji H, Watanabe H, Ishikawa H, Hu W, McPhee F, Linaberry M, Yin PD, Swenson ES, Kumada H.

J Gastroenterol. 2016 Aug 9. [Epub ahead of print]

PMID: 27502287

 

Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids.

Wang J, Qin T, Chen TG, Wimmer L, Edwards JT, Cornella J, Vokits B, Shaw SA, Baran PS.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9676-9. doi: 10.1002/anie.201605463.

PMID: 27380912

 

Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human.

Haarhoff ZE, Kramer MA, Zvyaga TA, Zhang J, Bhutani P, Subramanian M, Rodrigues AD.

Xenobiotica. 2016 Aug 8:1-9. [Epub ahead of print]

PMID: 27498589

 

In vitro model systems to investigate bile salt export pump (BSEP) activity and drug interactions: A review.

Cheng Y, Woolf TF, Gan J, He K.

Chem Biol Interact. 2016 Aug 5;255:23-30. doi: 10.1016/j.cbi.2015.11.029. Review.

PMID: 26683212

 

A randomized trial of Plasma-Lyte A and 0.9 % sodium chloride in acute pediatric gastroenteritis.

Allen CH, Goldman RD, Bhatt S, Simon HK, Gorelick MH, Spandorfer PR, Spiro DM, Mace SE, Johnson DW, Higginbotham EA, Du H, Smyth BJ, Schermer CR, Goldstein SL.

BMC Pediatr. 2016 Aug 2;16:117. doi: 10.1186/s12887-016-0652-4.

PMID: 27480410

 

Mathematical Model-Based Accelerated Development of Extended-release Metformin Hydrochloride Tablet Formulation.

Chen W, Desai D, Good D, Crison J, Timmins P, Paruchuri S, Wang J, Ha K.

AAPS PharmSciTech. 2016 Aug;17(4):1007-13. doi: 10.1208/s12249-015-0423-9.

PMID: 26729531

 

Sustained improvements in MRI outcomes with abatacept following the withdrawal of all treatments in patients with early, progressive rheumatoid arthritis.

Peterfy C, Burmester GR, Bykerk VP, Combe BG, DiCarlo JC, Furst DE, Huizinga TW, Wong DA, Conaghan PG, Emery P.

Ann Rheum Dis. 2016 Aug;75(8):1501-5. doi: 10.1136/annrheumdis-2015-208258.

PMID: 26865601

 

Recent developments in software tools for high-throughput in vitro ADME support with high-resolution MS.

Paiva A, Shou WZ.

Bioanalysis. 2016 Aug;8(16):1723-33. doi: 10.4155/bio-2016-0074. Review.

PMID: 27487387

 

Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS.

Mehl JT, Sleczka BG, Ciccimaro EF, Kozhich AT, Gilbertson DG, Vuppugalla R, Huang CS, Stevens B, Mo J, Deyanova EG, Wang Y, Huang RY, Chen G, Olah TV.

Bioanalysis. 2016 Aug;8(15):1611-1622.

PMID: 27397670

 

Immunoaffinity-coupled MS: best of both technologies.

DeSilva B.

Bioanalysis. 2016 Aug;8(15):1543-1544. No abstract available.

PMID: 27396588

 

Modelling Comparative Efficacy of Drugs with Different Survival Profiles: Ipilimumab, Vemurafenib and Dacarbazine in Advanced Melanoma.

Lee D, Porter J, Hertel N, Hatswell AJ, Briggs A.

BioDrugs. 2016 Aug;30(4):307-19. doi: 10.1007/s40259-016-0178-1.

PMID: 27177756

 

Identifying and retargeting transcriptional hot spots in the human genome.

Cheng JK, Lewis AM, Kim do S, Dyess T, Alper HS.

Biotechnol J. 2016 Aug;11(8):1100-9. doi: 10.1002/biot.201600015.

PMID: 27311394

 

Lack of a Pharmacokinetic Interaction Between Saxagliptin and Dapagliflozin in Healthy Subjects: A Randomized Crossover Study.

Vakkalagadda B, Lubin S, Reynolds L, Liang D, Marion AS, LaCreta F, Boulton DW.

Clin Ther. 2016 Aug;38(8):1890-9. doi: 10.1016/j.clinthera.2016.07.005.

PMID: 27491280

 

Cost-effectiveness of pazopanib compared with sunitinib in metastatic renal cell carcinoma in Canada.

Amdahl J, Diaz J, Park J, Nakhaipour HR, Delea TE.

Curr Oncol. 2016 Aug;23(4):e340-54. doi: 10.3747/co.23.2244.

PMID: 27536183

 

Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs.

Cheng Y, Ma L, Chang SY, Humphreys WG, Li W.

Drug Metab Dispos. 2016 Aug;44(8):1372-80. doi: 10.1124/dmd.116.070409.

PMID: 27226352

 

Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.

Bohnert T, Patel A, Templeton I, Chen Y, Lu C, Lai G, Leung L, Tse S, Einolf HJ, Wang YH, Sinz M, Stearns R, Walsky R, Geng W, Sudsakorn S, Moore D, He L, Wahlstrom J, Keirns J, Narayanan R, Lang D, Yang X; International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group..

Drug Metab Dispos. 2016 Aug;44(8):1399-423. doi: 10.1124/dmd.115.069096.

PMID: 27052879

 

Metabolic characterization of AH-7921, a synthetic opioid designer drug: in vitro metabolic stability assessment and metabolite identification, evaluation of in silico prediction, and in vivo confirmation.

Wohlfarth A, Scheidweiler KB, Pang S, Zhu M, Castaneto M, Kronstrand R, Huestis MA.

Drug Test Anal. 2016 Aug;8(8):779-91. doi: 10.1002/dta.1856.

PMID: 26331297

 

New Directions For Foundations In Health Equity.

Doykos P, Gray-Akpa K, Mitchell F.

Health Aff (Millwood). 2016 Aug 1;35(8):1536-40. doi: 10.1377/hlthaff.2016.0256.

PMID: 27503980

 

Reply.

Miller V, Harrington P, Howe A, Kieffer T, Lennerstrand J, Lenz O, Lontok E, McPhee F, Mo H, Parkin N, Pilot-Matias T.

Hepatology. 2016 Aug;64(2):698-9. doi: 10.1002/hep.28615. No abstract available.

PMID: 27113118

 

The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves.

Feld M, Garcia R, Buddenkotte J, Katayama S, Lewis K, Muirhead G, Hevezi P, Plesser K, Schrumpf H, Krjutskov K, Sergeeva O, Müller HW, Tsoka S, Kere J, Dillon SR, Steinhoff M, Homey B.

J Allergy Clin Immunol. 2016 Aug;138(2):500-508.e24. doi: 10.1016/j.jaci.2016.02.020.

PMID: 27212086

 

Comparison of Demographic and Clinical Characteristics of Hispanic and Asian Chronic Hepatitis B Patients in Southern California.

Zhu J, Khemichian S, Nghiem D, Zhang SR, Limurti J, Saito T, Fong TL.

J Clin Gastroenterol. 2016 Aug;50(7):602-7. doi: 10.1097/MCG.0000000000000486.

PMID: 26890328

 

Opening New Frontiers in the Development of Life Sciences Technology with Collaborative 3D Printing Technology.

Gill JM 2nd, Hart AS.

J Lab Autom. 2016 Aug;21(4):487-8. doi: 10.1177/2211068216647323. No abstract available.

PMID: 27422022

 

Comparison of hospital length of stay and hospitalization costs among patients with non-valvular atrial fibrillation treated with apixaban or warfarin: An early view.

Xie L, Vo L, Keshishian A, Price K, Singh P, Mardekian J, Bruno A, Baser O, Kim J, Tan W, Trocio J.

J Med Econ. 2016 Aug;19(8):769-76. doi: 10.3111/13696998.2016.1171774.

PMID: 27028360

 

Association of Autoimmune Encephalitis With Combined Immune Checkpoint Inhibitor Treatment for Metastatic Cancer.

Williams TJ, Benavides DR, Patrice KA, Dalmau JO, de Ávila AL, Le DT, Lipson EJ, Probasco JC, Mowry EM.

JAMA Neurol. 2016 Aug 1;73(8):928-33. doi: 10.1001/jamaneurol.2016.1399.

PMID: 27271951

 

Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion.

Chen Y, Wang S, Wang S, Liu C, Su C, Hageman M, Hussain M, Haskell R, Stefanski K, Qian F.

Mol Pharm. 2016 Aug 1;13(8):2787-95. doi: 10.1021/acs.molpharmaceut.6b00391.

PMID: 27337060

 

40 Hz Auditory Steady-State Response Is a Pharmacodynamic Biomarker for Cortical NMDA Receptors.

Sivarao DV, Chen P, Senapati A, Yang Y, Fernandes A, Benitex Y, Whiterock V, Li YW, Ahlijanian MK.

Neuropsychopharmacology. 2016 Aug;41(9):2232-40. doi: 10.1038/npp.2016.17.

PMID: 26837462

 

Special endpoint and product specific considerations in pharmaceutical acceptable daily exposure derivation.

Gould J, Callis CM, Dolan DG, Stanard B, Weideman PA.

Regul Toxicol Pharmacol. 2016 Aug;79 Suppl 1:S79-93. doi: 10.1016/j.yrtph.2016.05.022.

PMID: 27233924

 

The regulatory framework for preventing cross-contamination of pharmaceutical products: History and considerations for the future.

Sargent EV, Flueckiger A, Barle EL, Luo W, Molnar LR, Sandhu R, Weideman PA.

Regul Toxicol Pharmacol. 2016 Aug;79 Suppl 1:S3-S10. doi: 10.1016/j.yrtph.2016.05.029.

PMID: 27230736

 

Advances in mechanistic understanding of release rate control mechanisms of extended-release hydrophilic matrix tablets.

Timmins P, Desai D, Chen W, Wray P, Brown J, Hanley S.

Ther Deliv. 2016 Aug;7(8):553-72. doi: 10.4155/tde-2016-0026.

PMID: 27444495

 

Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development.

Halpern WG, Ameri M, Bowman CJ, Elwell MR, Mirsky ML, Oliver J, Regan KS, Remick AK, Sutherland VL, Thompson KE, Tremblay C, Yoshida M, Tomlinson L.

Toxicol Pathol. 2016 Aug;44(6):789-809. doi: 10.1177/0192623316650052.

PMID: 27235322

 

Molecular perspective of antibody aggregates and their adsorption on Protein A resin.

Yu D, Song Y, Huang RY, Swanson RK, Tan Z, Schutsky E, Lewandowski A, Chen G, Li ZJ.

J Chromatogr A. 2016 Jul 29;1457:66-75. doi: 10.1016/j.chroma.2016.06.031.

PMID: 27344283

 

A Landscape of Pharmacogenomic Interactions in Cancer.

Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Cokelaer T, Greninger P, van Dyk E, Chang H, de Silva H, Heyn H, Deng X, Egan RK, Liu Q, Mironenko T, Mitropoulos X, Richardson L, Wang J, Zhang T, Moran S, Sayols S, Soleimani M, Tamborero D, Lopez-Bigas N, Ross-Macdonald P, Esteller M, Gray NS, Haber DA, Stratton MR, Benes CH, Wessels LF, Saez-Rodriguez J, McDermott U, Garnett MJ.

Cell. 2016 Jul 28;166(3):740-54. doi: 10.1016/j.cell.2016.06.017.

PMID: 27397505

 

 The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia.

Bristow LJ, Easton AE, Li YW, Sivarao DV, Lidge R, Jones KM, Post-Munson D, Daly C, Lodge NJ, Gallagher L, Molski T, Pieschl R, Chen P, Hendricson A, Westphal R, Cook J, Iwuagwu C, Morgan D, Benitex Y, King D, Macor JE, Zaczek R, Olson R.

PLoS One. 2016 Jul 28;11(7):e0159996. doi: 10.1371/journal.pone.0159996.

PMID: 27467081

 

Ligand-Promoted Meta-C-H Arylation of Anilines, Phenols, and Heterocycles.

Wang P, Farmer ME, Huo X, Jain P, Shen PX, Ishoey M, Bradner JE, Wisniewski SR, Eastgate MD, Yu JQ.

J Am Chem Soc. 2016 Jul 27;138(29):9269-76. doi: 10.1021/jacs.6b04966.

PMID:

 

(19) F NMR Spectroscopy as a Highly Sensitive Method for the Direct Monitoring of Confined Crystallization within Nanoporous Materials.

Nartowski KP, Malhotra D, Hawarden LE, Sibik J, Iuga D, Zeitler JA, Fábián L, Khimyak YZ.

Angew Chem Int Ed Engl. 2016 Jul 25;55(31):8904-8. doi: 10.1002/anie.201602936.

PMID: 27272008

 

Phase III Randomized Trial of Ipilimumab Plus Etoposide and Platinum Versus Placebo Plus Etoposide and Platinum in Extensive-Stage Small-Cell Lung Cancer.

Reck M, Luft A, Szczesna A, Havel L, Kim SW, Akerley W, Pietanza MC, Wu YL, Zielinski C, Thomas M, Felip E, Gold K, Horn L, Aerts J, Nakagawa K, Lorigan P, Pieters A, Kong Sanchez T, Fairchild J, Spigel D.

J Clin Oncol. 2016 Jul 25. pii: JCO676601. [Epub ahead of print]

PMID: 27458307

 

No clinically significant pharmacokinetic interactions between dolutegravir and daclatasvir in healthy adult subjects.

Ross LL, Song IH, Arya N, Choukour M, Zong J, Huang SP, Eley T, Wynne B, Buchanan AM.

BMC Infect Dis. 2016 Jul 22;16:347. doi: 10.1186/s12879-016-1629-5.

PMID: 27450277

 

Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.

Yamniuk AP, Suri A, Krystek SR, Tamura J, Ramamurthy V, Kuhn R, Carroll K, Fleener C, Ryseck R, Cheng L, An Y, Drew P, Grant S, Suchard SJ, Nadler SG, Bryson JW, Sheriff S.

J Mol Biol. 2016 Jul 17;428(14):2860-79. doi: 10.1016/j.jmb.2016.05.014.

PMID: 27216500

 

Discovery of hydroxyl 1,2-diphenylethanamine analogs as potent cholesterol ester transfer protein inhibitors.

Jiang J, Finlay H, Johnson JA, Harikrishnan L, Kamau M, Qiao J, Wang T, Adam L, Taylor D, Yang R, Sleph P, Chen AY, Yin X, Wexler R, Salvati ME.

Bioorg Med Chem Lett. 2016 Jul 15;26(14):3278-81. doi: 10.1016/j.bmcl.2016.05.058.

PMID: 27256912

 

Exploitation of the size-exclusion effect of reversed-phase high performance liquid chromatography for the direct analysis of diethylene triamine pentaacetic acid in therapeutic monoclonal antibody formulations.

Huang JZ, Liao K, Wang G, Haby T, Bolgar MS.

J Chromatogr A. 2016 Jul 15;1455:140-6. doi: 10.1016/j.chroma.2016.05.087.

PMID: 27295965

 

Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates.

Wang C, Chen S, Caceres-Cortes J, Huang RY, Tymiak AA, Zhang Y.

J Chromatogr A. 2016 Jul 15;1455:133-9. doi: 10.1016/j.chroma.2016.05.086.

PMID: 27286648

 

Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).

Gilmore JL, Sheppeck JE 2nd, Watterson SH, Haque L, Mukhopadhyay P, Tebben AJ, Galella MA, Shen DR, Yarde M, Cvijic ME, Borowski V, Gillooly K, Taylor T, McIntyre KW, Warrack B, Levesque PC, Li JP, Cornelius G, D'Arienzo C, Marino A, Balimane P, Salter-Cid L, Barrish JC, Pitts WJ, Carter PH, Xie J, Dyckman AJ.

J Med Chem. 2016 Jul 14;59(13):6248-64. doi: 10.1021/acs.jmedchem.6b00373.

PMID: 27309907

 

Coarse-Grained Antibody Models for "Weak" Protein-Protein Interactions from Low to High Concentrations.

Calero-Rubio C, Saluja A, Roberts CJ.

J Phys Chem B. 2016 Jul 14;120(27):6592-605. doi: 10.1021/acs.jpcb.6b04907.

PMID: 27314827

 

Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial.

Cortes JE, Saglio G, Kantarjian HM, Baccarani M, Mayer J, Boqué C, Shah NP, Chuah C, Casanova L, Bradley-Garelik B, Manos G, Hochhaus A.

J Clin Oncol. 2016 Jul 10;34(20):2333-40. doi: 10.1200/JCO.2015.64.8899.

PMID: 27217448

 

Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations.

Nicolaou KC, Wang Y, Lu M, Mandal D, Pattanayak MR, Yu R, Shah AA, Chen JS, Zhang H, Crawford JJ, Pasunoori L, Poudel YB, Chowdari NS, Pan C, Nazeer A, Gangwar S, Vite G, Pitsinos EN.

J Am Chem Soc. 2016 Jul 6;138(26):8235-46. doi: 10.1021/jacs.6b04339.

PMID: 27266267

 

Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap.

Vincentz JW, Casasnovas JJ, Barnes RM, Que J, Clouthier DE, Wang J, Firulli AB.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7563-8. doi: 10.1073/pnas.1603930113.

PMID: 27335460

 

 Sex differences and hormonal effects on gut microbiota composition in mice.

Org E, Mehrabian M, Parks BW, Shipkova P, Liu X, Drake TA, Lusis AJ.

Gut Microbes. 2016 Jul 3;7(4):313-322.

PMID: 27355107

 

Development and Validation of Electrochemiluminescence Assays to Measure Free and Total sSLAMF7 in Human Serum in the Absence and Presence of Elotuzumab.

Postelnek J, Neely RJ, Robbins MD, Gleason CR, Peterson JE, Piccoli SP.

AAPS J. 2016 Jul;18(4):989-99. doi: 10.1208/s12248-016-9912-3.

PMID: 27116021

 

Impact of Pre-existing NS5A-L31 or -Y93H Minor Variants on Response Rates in Patients Infected with HCV Genotype-1b Treated with Daclatasvir/Asunaprevir.

Hernandez D, Yu F, Huang X, Kirov S, Pant S, McPhee F.

Adv Ther. 2016 Jul;33(7):1169-79. doi: 10.1007/s12325-016-0354-1.

PMID: 27287851

 

A Comprehensive Overview of Direct Oral Anticoagulants for the Management of Venous Thromboembolism.

Comerota AJ, Ramacciotti E.

Am J Med Sci. 2016 Jul;352(1):92-106. doi: 10.1016/j.amjms.2016.03.018. Review.

PMID: 27432042

 

Safety and efficacy of daclatasvir in the management of patients with chronic hepatitis C.

Manolakopoulos S, Zacharakis G, Zissis M, Giannakopoulos V.

Ann Gastroenterol. 2016 Jul-Sep;29(3):282-96. doi: 10.20524/aog.2016.0041. Review.

PMID: 27366028

 

Designing proteins to combat disease: Cardiac troponin C as an example.

Davis JP, Shettigar V, Tikunova SB, Little SC, Liu B, Siddiqui JK, Janssen PM, Ziolo MT, Walton SD.

Arch Biochem Biophys. 2016 Jul 1;601:4-10. doi: 10.1016/j.abb.2016.02.007.

PMID: 26901433

 

Patient-Reported Outcomes From a Two-Year Head-to-Head Comparison of Subcutaneous Abatacept and Adalimumab for Rheumatoid Arthritis.

Fleischmann R, Weinblatt ME, Schiff M, Khanna D, Maldonado MA, Nadkarni A, Furst DE.

Arthritis Care Res (Hoboken). 2016 Jul;68(7):907-13. doi: 10.1002/acr.22763.

PMID: 26473625

 

 Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays.

Wang J, Gu H, Liu A, Kozhich A, Rangan V, Myler H, Luo L, Wong R, Sun H, Wang B, Vezina HE, Deshpande S, Zhang Y, Yang Z, Olah TV, Aubry AF, Arnold ME, Pillutla R, DeSilva B.

Bioanalysis. 2016 Jul;8(13):1383-401. doi: 10.4155/bio-2016-0017.

PMID: 27277879

 

Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment.

Cheng Y, Freeden C, Zhang Y, Abraham P, Shen H, Wescott D, Humphreys WG, Gan J, Lai Y.

Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011.

PMID: 27059119

 

Real-world treatment practice in patients with advanced melanoma in the era before ipilimumab: results from the IMAGE study.

Middleton MR, Dalle S, Claveau J, Mut P, Hallmeyer S, Plantin P, Highley M, Kotapati S, Le TK, Brokaw J, Abernethy AP.

Cancer Med. 2016 Jul;5(7):1436-43. doi: 10.1002/cam4.717.

PMID: 27118102

 

In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments.

Morris ZS, Guy EI, Francis DM, Gressett MM, Werner LR, Carmichael LL, Yang RK, Armstrong EA, Huang S, Navid F, Gillies SD, Korman A, Hank JA, Rakhmilevich AL, Harari PM, Sondel PM.

Cancer Res. 2016 Jul 1;76(13):3929-41. doi: 10.1158/0008-5472.CAN-15-2644.

PMID: 27197149

 

Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy.

Chan JL, Koda J, Heilig JS, Cochran EK, Gorden P, Oral EA, Brown RJ.

Clin Endocrinol (Oxf). 2016 Jul;85(1):137-49. doi: 10.1111/cen.12980.

PMID: 26589105

 

Evaluation of Crushed Tablet for Oral Administration and the Effect of Food on Apixaban Pharmacokinetics in Healthy Adults.

Song Y, Chang M, Suzuki A, Frost RJ, Kelly A, LaCreta F, Frost C.

Clin Ther. 2016 Jul;38(7):1674-1685.e1. doi: 10.1016/j.clinthera.2016.05.004.

PMID: 27292282

 

 Pharmacokinetics and pharmacodynamics of dapagliflozin in children and adolescents with type 2 diabetes mellitus.

Tirucherai GS, LaCreta F, Ismat FA, Tang W, Boulton DW.

Diabetes Obes Metab. 2016 Jul;18(7):678-84. doi: 10.1111/dom.12638.

PMID: 27291448

 

Long-Term Safety of Dapagliflozin in Older Patients with Type 2 Diabetes Mellitus: A Pooled Analysis of Phase IIb/III Studies.

Fioretto P, Mansfield TA, Ptaszynska A, Yavin Y, Johnsson E, Parikh S.

Drugs Aging. 2016 Jul;33(7):511-22. doi: 10.1007/s40266-016-0382-1.

PMID: 27357173

 

Implementation of mechanism of action biology-driven early drug development for children with cancer.

Pearson AD, Herold R, Rousseau R, Copland C, Bradley-Garelik B, Binner D, Capdeville R, Caron H, Carleer J, Chesler L, Geoerger B, Kearns P, Marshall LV, Pfister SM, Schleiermacher G, Skolnik J, Spadoni C, Sterba J, van den Berg H, Uttenreuther-Fischer M, Witt O, Norga K, Vassal G; Members of Working Group 1 of the Paediatric Platform of ACCELERATE..

Eur J Cancer. 2016 Jul;62:124-31. doi: 10.1016/j.ejca.2016.04.001.

PMID: 27258969

 

RECIST 1.1 - Standardisation and disease-specific adaptations: Perspectives from the RECIST Working Group.

Schwartz LH, Seymour L, Litière S, Ford R, Gwyther S, Mandrekar S, Shankar L, Bogaerts J, Chen A, Dancey J, Hayes W, Hodi FS, Hoekstra OS, Huang EP, Lin N, Liu Y, Therasse P, Wolchok JD, de Vries E.

Eur J Cancer. 2016 Jul;62:138-45. doi: 10.1016/j.ejca.2016.03.082.

PMID: 27237360

 

RECIST 1.1-Update and clarification: From the RECIST committee.

Schwartz LH, Litière S, de Vries E, Ford R, Gwyther S, Mandrekar S, Shankar L, Bogaerts J, Chen A, Dancey J, Hayes W, Hodi FS, Hoekstra OS, Huang EP, Lin N, Liu Y, Therasse P, Wolchok JD, Seymour L.

Eur J Cancer. 2016 Jul;62:132-7. doi: 10.1016/j.ejca.2016.03.081.

PMID: 27189322

  

Reliability among central readers in the evaluation of endoscopic findings from patients with Crohn's disease.

Khanna R, Zou G, D'Haens G, Rutgeerts P, McDonald JW, Daperno M, Feagan BG, Sandborn WJ, Dubcenco E, Stitt L, Vandervoort MK, Donner A, Luo A, Levesque BG.

Gut. 2016 Jul;65(7):1119-25. doi: 10.1136/gutjnl-2014-308973.

PMID: 25935574

 

384-Well Multiplexed Luminex Cytokine Assays for Lead Optimization.

Tang H, Panemangalore R, Yarde M, Zhang L, Cvijic ME.

J Biomol Screen. 2016 Jul;21(6):548-55. doi: 10.1177/1087057116644164.

PMID: 27095819

 

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.

Toyn JH, Boy KM, Raybon J, Meredith JE Jr, Robertson AS, Guss V, Hoque N, Sweeney F, Zhuo X, Clarke W, Snow K, Denton RR, Zuev D, Thompson LA, Morrison J, Grace J, Berisha F, Furlong M, Wang JS, Lentz KA, Padmanabha R, Cook L, Wei C, Drexler DM, Macor JE, Albright CF, Gasior M, Olson RE, Hong Q, Soares HD, AbuTarif M, Ahlijanian MK.

J Pharmacol Exp Ther. 2016 Jul;358(1):125-37. doi: 10.1124/jpet.116.232249.

PMID: 27189974

 

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers.

Soares HD, Gasior M, Toyn JH, Wang JS, Hong Q, Berisha F, Furlong MT, Raybon J, Lentz KA, Sweeney F, Zheng N, Akinsanya B, Berman RM, Thompson LA, Olson RE, Morrison J, Drexler DM, Macor JE, Albright CF, Ahlijanian MK, AbuTarif M.

J Pharmacol Exp Ther. 2016 Jul;358(1):138-50. doi: 10.1124/jpet.116.232256.

PMID: 27189973

 

Evaluation of cardiac function in unrestrained dogs and monkeys using left ventricular dP/dt.

Buchanan LV, Warner WA, Arthur SR, Gleason CR, Lewen G, Levesque PC, Gill MW.

J Pharmacol Toxicol Methods. 2016 Jul-Aug;80:51-8. doi: 10.1016/j.vascn.2016.03.006.

PMID: 27063376

 

Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation in Relation to Renal Function Over Time: Insights From the ARISTOTLE Randomized Clinical Trial.

Hijazi Z, Hohnloser SH, Andersson U, Alexander JH, Hanna M, Keltai M, Parkhomenko A, López-Sendón JL, Lopes RD, Siegbahn A, Granger CB, Wallentin L.

JAMA Cardiol. 2016 Jul 1;1(4):451-60. doi: 10.1001/jamacardio.2016.1170.

PMID: 27438322

 

Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: a randomised, open-label, phase 3 trial.

Cella D, Grünwald V, Nathan P, Doan J, Dastani H, Taylor F, Bennett B, DeRosa M, Berry S, Broglio K, Berghorn E, Motzer RJ.

Lancet Oncol. 2016 Jul;17(7):994-1003. doi: 10.1016/S1470-2045(16)30125-5.

PMID: 27283863

 

Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial.

Antonia SJ, López-Martin JA, Bendell J, Ott PA, Taylor M, Eder JP, Jäger D, Pietanza MC, Le DT, de Braud F, Morse MA, Ascierto PA, Horn L, Amin A, Pillai RN, Evans J, Chau I, Bono P, Atmaca A, Sharma P, Harbison CT, Lin CS, Christensen O, Calvo E.

Lancet Oncol. 2016 Jul;17(7):883-95. doi: 10.1016/S1470-2045(16)30098-5.

PMID: 27269741

 

Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial.

Weber JS, Gibney G, Sullivan RJ, Sosman JA, Slingluff CL Jr, Lawrence DP, Logan TF, Schuchter LM, Nair S, Fecher L, Buchbinder EI, Berghorn E, Ruisi M, Kong G, Jiang J, Horak C, Hodi FS.

Lancet Oncol. 2016 Jul;17(7):943-55. doi: 10.1016/S1470-2045(16)30126-7.

PMID: 27269740

 

Low incidence of peripheral arterial disease in patients receiving dasatinib in clinical trials.

le Coutre PD, Hughes TP, Mahon FX, Kim DW, Steegmann JL, Shah NP, Gooden K, Wallis N, Cortes JE.

Leukemia. 2016 Jul;30(7):1593-6. doi: 10.1038/leu.2015.352. No abstract available.

PMID: 26686247

 

Daclatasvir plus asunaprevir for HCV genotype 1b infection in patients with or without compensated cirrhosis: a pooled analysis.

Kao JH, Jensen DM, Manns MP, Jacobson I, Kumada H, Toyota J, Heo J, Yoffe B, Sievert W, Bessone F, Peng CY, Roberts SK, Lee YJ, Bhore R, Mendez P, Hughes E, Noviello S.

Liver Int. 2016 Jul;36(7):954-62. doi: 10.1111/liv.13049.

PMID: 26683763

 

Detection and quantification of RNA 2'-O-methylation and pseudouridylation.

Huang C, Karijolich J, Yu YT.

Methods. 2016 Jul 1;103:68-76. doi: 10.1016/j.ymeth.2016.02.003.

PMID: 26853326

 

Postmarketing surveillance of the safety and effectiveness of abatacept in Japanese patients with rheumatoid arthritis.

Harigai M, Ishiguro N, Inokuma S, Mimori T, Ryu J, Takei S, Takeuchi T, Tanaka Y, Takasaki Y, Yamanaka H, Watanabe M, Tamada H, Koike T.

Mod Rheumatol. 2016 Jul;26(4):491-8. doi: 10.3109/14397595.2015.1123211.

PMID: 26635183

 

 Organizational effectiveness: a key to R&D productivity.

Tollman P, Panier V, Dosik D, Biondi P, Cuss F.

Nat Rev Drug Discov. 2016 Jul;15(7):441-2. doi: 10.1038/nrd.2016.91.

PMID: 27312725

 

A Biopharmaceutical Industry Perspective on the Control of Visible Particles in Biotechnology-Derived Injectable Drug Products.

Mathonet S, Mahler HC, Esswein ST, Mazaheri M, Cash PW, Wuchner K, Kallmeyer G, Das TK, Finkler C, Lennard A.

PDA J Pharm Sci Technol. 2016 Jul-Aug;70(4):392-408. doi: 10.5731/pdajpst.2015.006189.

PMID: 27091885

 

Effects of antipsychotics on cortisol, interleukin-6 and hippocampal perfusion in healthy volunteers.

Handley R, Mondelli V, Zelaya F, Marques T, Taylor H, Reinders AA, Chaddock C, McQueen G, Hubbard K, Papadopoulos A, Williams S, McGuire P, Pariante C, Dazzan P.

Schizophr Res. 2016 Jul;174(1-3):99-105. doi: 10.1016/j.schres.2016.03.039.

PMID: 27112637

 

 Report of the European Society of Cardiology Cardiovascular Round Table regulatory workshop update of the evaluation of new agents for the treatment of acute coronary syndrome: Executive summary.

Bueno H, de Graeff P, Richard-Lordereau I, Emmerich J, Fox KA, Friedman CP, Gaudin C, El-Gazayerly A, Goldman S, Hemmrich M, Henderson RA, Himmelmann A, Irs A, Jackson N, James SK, Katus HA, Laslop A, Laws I, Mehran R, Ong S, Prasad K, Roffi M, Rosano GM, Rose M, Sinnaeve PR, Stough WG, Thygesen K, Van de Werf F, Varin C, Verheugt FW, de Los Angeles Alonso García M.

Eur Heart J Acute Cardiovasc Care. 2016 Jun 29. pii: 2048872616649859. [Epub ahead of print]

PMID: 27357206

 

Determination of process variables affecting drug particle attrition withinmulti-component blends during powder feed transmission.

Gamble JF, Dennis AB, Hutchins P, Jones JW, Musembi P, Tobyn M.

Pharm Dev Technol. 2016 Jun 27:1-6. [Epub ahead of print]

PMID: 27344924

 

A Fluorescence-Based High-Throughput Coupled Enzymatic Assay for Quantitation of Isoaspartate in Proteins and Peptides.

Puri A, Quan Y, Narang AS, Adams M, Gandhi R, Nashine VC.

AAPS PharmSciTech. 2016 Jun 24. [Epub ahead of print]

PMID: 27342117

 

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.

Nowicka-Sans B, Protack T, Lin Z, Li Z, Zhang S, Sun Y, Samanta H, Terry B, Liu Z, Chen Y, Sin N, Sit SY, Swidorski JJ, Chen J, Venables BL, Healy M, Meanwell NA, Cockett M, Hanumegowda U, Regueiro-Ren A, Krystal M, Dicker IB.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):3956-69. doi: 10.1128/AAC.02560-15.

PMID: 27090171

 

 Editorial: The Physiology and Pharmacology of Leucine-rich Repeat GPCRs.

Arey BJ, Dias JA.

Front Endocrinol (Lausanne). 2016 Jun 17;7:56. doi: 10.3389/fendo.2016.00056. No abstract available.

PMID: 27379012

 

B cells from African American lupus patients exhibit an activated phenotype.

Menard LC, Habte S, Gonsiorek W, Lee D, Banas D, Holloway DA, Manjarrez-Orduno N, Cunningham M, Stetsko D, Casano F, Kansal S, Davis PM, Carman J, Zhang CK, Abidi F, Furie R, Nadler SG, Suchard SJ.

JCI Insight. 2016 Jun 16;1(9):e87310.

PMID: 27699274

 

Understanding and Controlling Sialylation in a CHO Fc-Fusion Process.

Lewis AM, Croughan WD, Aranibar N, Lee AG, Warrack B, Abu-Absi NR, Patel R, Drew B, Borys MC, Reily MD, Li ZJ.

PLoS One. 2016 Jun 16;11(6):e0157111. doi: 10.1371/journal.pone.0157111.

PMID: 27310468

 

The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay.

Zheng JJ, Shields EE, Snow KJ, Nelson DM, Olah TV, Reily MD, Robertson DG, Shipkova PA, Stryker SA, Xin B, Drexler DM.

Anal Biochem. 2016 Jun 15;503:71-8. doi: 10.1016/j.ab.2016.03.011.

PMID: 27033006

 

12 Weeks of Daclatasvir in Combination With Sofosbuvir for HIV-HCV Coinfection (ALLY-2 Study): Efficacy and Safety by HIV Combination Antiretroviral Regimens.

Luetkemeyer AF, McDonald C, Ramgopal M, Noviello S, Bhore R, Ackerman P.

Clin Infect Dis. 2016 Jun 15;62(12):1489-96. doi: 10.1093/cid/ciw163.

PMID: 27025835

 

Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement.

Dahan R, Barnhart BC, Li F, Yamniuk AP, Korman AJ, Ravetch JV.

Cancer Cell. 2016 Jun 13;29(6):820-31. doi: 10.1016/j.ccell.2016.05.001.

PMID: 27265505

 

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model.

Archer AM, Saber R, Rose S, Shaffer A, Misharin AV, Tsai F, Haines Iii GK, Dominguez S, Eren M, Vaughan DE, Cuda CM, Perlman H.

J Transl Med. 2016 Jun 10;14(1):170. doi: 10.1186/s12967-016-0912-y.

PMID: 27287704

 

Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor.

Finlay HJ, Johnson JA, Lloyd JL, Jiang J, Neels J, Gunaga P, Banerjee A, Dhondi N, Chimalakonda A, Mandlekar S, Conder ML, Sale H, Xing D, Levesque P, Wexler RR.

ACS Med Chem Lett. 2016 Jun 9;7(9):831-4. doi: 10.1021/acsmedchemlett.6b00117.

PMID: 27660686

 

Randomized phase 2 study: elotuzumab plus bortezomib/dexamethasone vs bortezomib/dexamethasone for relapsed/refractory MM.

Jakubowiak A, Offidani M, Pégourie B, De La Rubia J, Garderet L, Laribi K, Bosi A, Marasca R, Laubach J, Mohrbacher A, Carella AM, Singhal AK, Tsao LC, Lynch M, Bleickardt E, Jou YM, Robbins M, Palumbo A.

Blood. 2016 Jun 9;127(23):2833-40. doi: 10.1182/blood-2016-01-694604.

PMID: 27091875

 

A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses.

Sheaffer AK, Lee MS, Qi H, Chaniewski S, Zheng X, Farr GA, Esposito K, Harden D, Lei M, Schweizer L, Friborg J, Agler M, McPhee F, Gentles R, Beno BR, Chupak L, Mason S.

PLoS One. 2016 Jun 9;11(6):e0155909. doi: 10.1371/journal.pone.0155909.

PMID: 27280728

 

Examining Manufacturing Readiness for Breakthrough Drug Development.

Dye E, Sturgess A, Maheshwari G, May K, Ruegger C, Ramesh U, Tan H, Cockerill K, Groskoph J, Lacana E, Lee S, Miksinski SP.

AAPS PharmSciTech. 2016 Jun;17(3):529-38. doi: 10.1208/s12249-015-0455-1. Review. No abstract available.

PMID: 26608693

 

[Cost-effectiveness analysis of apixaban versus acetylsalicylic acid in the prevention of stroke in patients with non-valvular atrial fibrillation in Spain].

Escolar-Albaladejo G, Barón-Esquivias G, Zamorano JL, Betegón-Nicolás L, Canal-Fontcuberta C, de Salas-Cansado M, Rubio-Rodríguez D, Rubio-Terrés C.

Aten Primaria. 2016 Jun-Jul;48(6):394-405. doi: 10.1016/j.aprim.2015.04.012. Spanish.

PMID: 26832316

 

Rendering the 3 + 3 Design to Rest: More Efficient Approaches to Oncology Dose-Finding Trials in the Era of Targeted Therapy.

Nie L, Rubin EH, Mehrotra N, Pinheiro J, Fernandes LL, Roy A, Bailey S, de Alwis DP.

Clin Cancer Res. 2016 Jun 1;22(11):2623-9. doi: 10.1158/1078-0432.CCR-15-2644.

PMID: 27250933

 

Case report: successful retreatment of hepatitis C genotype 1b infection with sofosbuvir + simeprevir in a patient with cirrhosis who had prior virologic relapse after treatment with daclatasvir and asunaprevir.

Safadi R, Noviello S, Boparai N, McPhee F.

Clin Case Rep. 2016 Jun 1;4(7):653-6. doi: 10.1002/ccr3.581.

PMID: 27386121

 

Cross-Intolerance With Dasatinib Among Imatinib-Intolerant Patients With Chronic Phase Chronic Myeloid Leukemia.

Khoury HJ, Goldberg SL, Mauro MJ, Stone RM, Deininger MW, Bradley-Garelik MB, Mohamed H, Guilhot F.

Clin Lymphoma Myeloma Leuk. 2016 Jun;16(6):341-349.e1. doi: 10.1016/j.clml.2016.03.004.

PMID: 27133948

 

Chronic hepatitis C: Burden of disease and cost associated with hospitalisations in France in 2012 (The HEPC-LONE study).

Abergel A, Rotily M, Branchoux S, Akremi R, de Léotoing L, Vainchtock A, Gaudin AF.

Clin Res Hepatol Gastroenterol. 2016 Jun;40(3):340-8. doi: 10.1016/j.clinre.2015.08.006.

PMID: 26546175

 

Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.

Li W, Zhao W, Liu X, Huang X, Lopez OD, Leet JE, Fancher RM, Nguyen V, Goodrich J, Easter J, Hong Y, Caceres-Cortes J, Chang SY, Ma L, Belema M, Hamann LG, Gao M, Zhu M, Shu YZ, Humphreys WG, Johnson BM.

Drug Metab Dispos. 2016 Jun;44(6):809-20. doi: 10.1124/dmd.115.068866.

PMID: 27029743

 

An Integrated Approach for Studying Exposure, Metabolism, and Disposition of Multiple Component Herbal Medicines Using High-Resolution Mass Spectrometry and Multiple Data Processing Tools.

Wu C, Zhang H, Wang C, Qin H, Zhu M, Zhang J.

Drug Metab Dispos. 2016 Jun;44(6):800-8. doi: 10.1124/dmd.115.068189.

PMID: 27013399

 

Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection?

Festino L, Botti G, Lorigan P, Masucci GV, Hipp JD, Horak CE, Melero I, Ascierto PA.

Drugs. 2016 Jun;76(9):925-45. doi: 10.1007/s40265-016-0588-x. Review.

PMID: 27229745

 

Trial-based cost-effectiveness of abatacept for rheumatoid arthritis patients in Italy.

Gaultney J, Benucci M, Iannazzo S, Nappi C, Sion K, Sabater FJ.

Expert Rev Pharmacoecon Outcomes Res. 2016 Jun;16(3):409-17. doi: 10.1586/14737167.2016.1102636.

PMID: 26495961

 

A validated enantioselective LC-MS/MS assay for quantification of a major chiral metabolite of an achiral 11-β-hydroxysteroid-dehydrogenase 1 inhibitor in human plasma: Application to a clinical pharmacokinetic study.

Furlong MT, Ji QC, Iacono L, Dang O, Noren M, Bruce J, Aubry AF, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:167-72. doi: 10.1016/j.jchromb.2016.03.043.

PMID: 27100678

 

Semiautomated Sample Preparation for Protein Stability and Formulation Screening via Buffer Exchange.

Ying W, Levons JK, Carney A, Gandhi R, Vydra V, Rubin AE.

J Lab Autom. 2016 Jun;21(3):378-86. doi: 10.1177/2211068215585484.

PMID: 25969451

 

Economic evaluation of nivolumab for the treatment of second-line advanced squamous NSCLC in Canada: a comparison of modeling approaches to estimate and extrapolate survival outcomes.

Goeree R, Villeneuve J, Goeree J, Penrod JR, Orsini L, Tahami Monfared AA.

J Med Econ. 2016 Jun;19(6):630-44. doi: 10.3111/13696998.2016.1151432.

PMID: 26850122

 

Rates, factors, reasons, and economic impact associated with switching in rheumatoid arthritis patients newly initiated on biologic disease modifying anti-rheumatic drugs in an integrated healthcare system.

Rashid N, Lin AT, Aranda G Jr, Lin KJ, Guerrero VN, Nadkarni A, Patel C.

J Med Econ. 2016 Jun;19(6):568-75. doi: 10.3111/13696998.2016.1142448.

PMID: 26766553

 

Clinical and economic benefits of extended treatment with apixaban for the treatment and prevention of recurrent venous thromboembolism in Canada.

Quon P, Le HH, Raymond V, Mtibaa M, Moshyk A.

J Med Econ. 2016 Jun;19(6):557-67. doi: 10.3111/13696998.2016.1141780.

PMID: 26761644

 

The effect of dapagliflozin on renal function in patients with type 2 diabetes.

Kohan DE, Fioretto P, Johnsson K, Parikh S, Ptaszynska A, Ying L.

J Nephrol. 2016 Jun;29(3):391-400. doi: 10.1007/s40620-016-0261-1.

PMID: 26894924

 

Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays.

Newberry K, Wang S, Hoque N, Kiss L, Ahlijanian MK, Herrington J, Graef JD.

J Neurophysiol. 2016 Jun 1;115(6):3217-28. doi: 10.1152/jn.01122.2015.

PMID: 27052585

 

Correlation of Phosphorus Cross-Linking to Hydration Rates in Sodium Starch Glycolate Tablet Disintegrants Using MRI.

Abraham A, Olusanmi D, Ilott AJ, Good D, Murphy D, Mcnamara D, Jerschow A, Mantri RV.

J Pharm Sci. 2016 Jun;105(6):1907-13. doi: 10.1016/j.xphs.2016.03.025.

PMID: 27155767

 

Model-based pharmacokinetic analysis of elotuzumab in patients with relapsed/refractory multiple myeloma.

Gibiansky L, Passey C, Roy A, Bello A, Gupta M.

J Pharmacokinet Pharmacodyn. 2016 Jun;43(3):243-57. doi: 10.1007/s10928-016-9469-x.

PMID: 26993283

 

The Impact of State AIDS Drug Assistance Policies on Clinical and Economic Outcomes of People With HIV.

Snider JT, Goldman DP, Rosenblatt L, Seekins D, Juday T, Sanchez Y, Wu Y, Peneva D, Romley JA.

Med Care Res Rev. 2016 Jun;73(3):329-48. doi: 10.1177/1077558715614479.

PMID: 26537525

 

Key factors for successful data integration in biomarker research.

Elefsinioti A, Bellaire T, Wang A, Quast K, Seidel H, Braxenthaler M, Goeller G, Christianson A, Henderson D, Reischl J.

Nat Rev Drug Discov. 2016 Jun;15(6):369-70. doi: 10.1038/nrd.2016.74.

PMID: 27173942

 

Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity.

Ahlberg E, Amberg A, Beilke LD, Bower D, Cross KP, Custer L, Ford KA, Van Gompel J, Harvey J, Honma M, Jolly R, Joossens E, Kemper RA, Kenyon M, Kruhlak N, Kuhnke L, Leavitt P, Naven R, Neilan C, Quigley DP, Shuey D, Spirkl HP, Stavitskaya L, Teasdale A, White A, Wichard J, Zwickl C, Myatt GJ.

Regul Toxicol Pharmacol. 2016 Jun;77:1-12. doi: 10.1016/j.yrtph.2016.02.003.

PMID: 26879463

 

Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses.

Amberg A, Beilke L, Bercu J, Bower D, Brigo A, Cross KP, Custer L, Dobo K, Dowdy E, Ford KA, Glowienke S, Van Gompel J, Harvey J, Hasselgren C, Honma M, Jolly R, Kemper R, Kenyon M, Kruhlak N, Leavitt P, Miller S, Muster W, Nicolette J, Plaper A, Powley M, Quigley DP, Reddy MV, Spirkl HP, Stavitskaya L, Teasdale A, Weiner S, Welch DS, White A, Wichard J, Myatt GJ.

Regul Toxicol Pharmacol. 2016 Jun;77:13-24. doi: 10.1016/j.yrtph.2016.02.004.

PMID: 26877192

 

Effects of aripiprazole and haloperidol on neural activation during the n-back in healthy individuals: A functional MRI study.

Goozee R, Reinders AA, Handley R, Marques T, Taylor H, O'Daly O, McQueen G, Hubbard K, Mondelli V, Pariante C, Dazzan P.

Schizophr Res. 2016 Jun;173(3):174-81. doi: 10.1016/j.schres.2015.02.023.

PMID: 25778615

 

Physician and Patient Preferences for Nonvalvular Atrial Fibrillation Therapies.

Shafrin J, Bruno A, MacEwan JP, Campinha-Bacote A, Trocio J, Shah M, Tan W, Romley JA.

Value Health. 2016 Jun;19(4):451-9. doi: 10.1016/j.jval.2016.01.001.

PMID: 27325337

 

Impact of menstruation on select hematology and clinical chemistry variables in cynomolgus macaques.

Perigard CJ, Parrula MC, Larkin MH, Gleason CR.

Vet Clin Pathol. 2016 Jun;45(2):232-43. doi: 10.1111/vcp.12350.

PMID: 27061515

 

The syntheses of [(14) C]BMS-823778 for use in a human ADME clinical study and of [(13) CD3 (13) CD2 ]BMT-094817, a stable-isotope labeled standard of a newly detected human metabolite.

Maxwell BD, Tran SB, Lago M, Li J, Bonacorsi SJ Jr.

J Labelled Comp Radiopharm. 2016 May 30;59(6):255-9. doi: 10.1002/jlcr.3383.

PMID: 27169762

 

Structural characterization of low level degradants in aztreonam injection and an innovative approach to aid HPLC method validation.

Ye Q, Ding W, Rinaldi F, Huang Y, Miller SA, Bolgar M.

J Pharm Biomed Anal. 2016 May 30;124:358-64. doi: 10.1016/j.jpba.2016.03.017.

PMID: 26991056

 

Three strikes and research is out.

Orsini MJ.

Science. 2016 May 27;352(6289):1138. doi: 10.1126/science.352.6289.1138. No abstract available.

PMID: 27230382

 

Antibody response to pneumococcal and influenza vaccination in patients with rheumatoid arthritis receiving abatacept.

Alten R, Bingham CO 3rd, Cohen SB, Curtis JR, Kelly S, Wong D, Genovese MC.

BMC Musculoskelet Disord. 2016 May 26;17:231. doi: 10.1186/s12891-016-1082-z.

PMID: 27229685

 

Population Pharmacokinetics Analysis To Inform Efavirenz Dosing Recommendations in Pediatric HIV Patients Aged 3 Months to 3 Years.

Luo M, Chapel S, Sevinsky H, Savant I, Cirincione B, Bertz R, Roy A.

Antimicrob Agents Chemother. 2016 May 23;60(6):3676-86. doi: 10.1128/AAC.02678-15.

PMID: 27067333

 

The ABC (age, biomarkers, clinical history) stroke risk score: a biomarker-based risk score for predicting stroke in atrial fibrillation.

Hijazi Z, Lindbäck J, Alexander JH, Hanna M, Held C, Hylek EM, Lopes RD, Oldgren J, Siegbahn A, Stewart RA, White HD, Granger CB, Wallentin L; ARISTOTLE and STABILITY Investigators..

Eur Heart J. 2016 May 21;37(20):1582-90. doi: 10.1093/eurheartj/ehw054.

PMID: 26920728

 

Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors.

Shang Y, Yeatman HR, Provasi D, Alt A, Christopoulos A, Canals M, Filizola M.

ACS Chem Biol. 2016 May 20;11(5):1220-9. doi: 10.1021/acschembio.5b00712.

PMID: 26841170

 

Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop.

Houot R, Gaulard P, Schreiber R, Mellman I, Lambotte O, Coulie PG, Fest T, Korman A, Levy R, Shipp M, Tarte K, Kohrt H, Marabelle A, Ansell S, Watier H, van Elsas A, Balakumaran A, Arce Vargas F, Quezada SA, Salles G, Olive D.

Oncoimmunology. 2016 May 19;5(7):e1186323. doi: 10.1080/2162402X.2016.1186323.

PMID: 27622041

 

Biotechnology Based Process for Production of a Disulfide-Bridged Peptide.

Goswami A, Goldberg SL, Hanson RL, Johnston RM, Lyngberg OK, Chan Y, Lo E, Chan SH, de Mas N, Ramirez A, Doyle R, Ding W, Gao M, Krystek SR Jr, Wan C, Kim YJ, Calambur D, Witmer M, Bryson JW.

Bioconjug Chem. 2016 May 18;27(5):1276-84. doi: 10.1021/acs.bioconjchem.6b00101.

PMID: 27098672

 

Synthesis of Diverse (11)C-Labeled PET Radiotracers via Direct Incorporation of [(11)C]CO2.

Mossine AV, Brooks AF, Jackson IM, Quesada CA, Sherman P, Cole EL, Donnelly DJ, Scott PJ, Shao X.

Bioconjug Chem. 2016 May 18;27(5):1382-9. doi: 10.1021/acs.bioconjchem.6b00163.

PMID: 27043721

 

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

Patel MA, Kim JE, Theodros D, Tam A, Velarde E, Kochel CM, Francica B, Nirschl TR, Ghasemzadeh A, Mathios D, Harris-Bookman S, Jackson CC, Jackson C, Ye X, Tran PT, Tyler B, Coric V, Selby M, Brem H, Drake CG, Pardoll DM, Lim M.

J Immunother Cancer. 2016 May 17;4:28. doi: 10.1186/s40425-016-0132-2. Erratum in: J Immunother Cancer. 2016 Nov 4;4:74.

PMID: 27190629

 

Characterization of monoacylglycerol acyltransferase 2 inhibitors by a novel probe in binding assays.

Ma Z, Chao HJ, Turdi H, Hangeland JJ, Friends T, Kopcho LM, Lawrence RM, Cheng D.

Anal Biochem. 2016 May 15;501:48-55. doi: 10.1016/j.ab.2016.02.012.

PMID: 26925857

 

Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders.

Lu H, Kopcho L, Ghosh K, Witmer M, Parker M, Gupta S, Paul M, Krishnamurthy P, Laksmaiah B, Xie D, Tredup J, Zhang L, Abell LM.

Anal Biochem. 2016 May 15;501:56-65. doi: 10.1016/j.ab.2016.02.003.

PMID: 26874021

 

Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.

Corte JR, Fang T, Pinto DJ, Orwat MJ, Rendina AR, Luettgen JM, Rossi KA, Wei A, Ramamurthy V, Myers JE Jr, Sheriff S, Narayanan R, Harper TW, Zheng JJ, Li YX, Seiffert DA, Wexler RR, Quan ML.

Bioorg Med Chem. 2016 May 15;24(10):2257-72. doi: 10.1016/j.bmc.2016.03.062.

PMID: 27073051

 

Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).

Guo J, Watterson SH, Spergel SH, Kempson J, Langevine CM, Shen DR, Yarde M, Cvijic ME, Banas D, Liu R, Suchard SJ, Gillooly K, Taylor T, Rex-Rabe S, Shuster DJ, McIntyre KW, Cornelius G, D'Arienzo C, Marino A, Balimane P, Salter-Cid L, McKinnon M, Barrish JC, Carter PH, Pitts WJ, Xie J, Dyckman AJ.

Bioorg Med Chem Lett. 2016 May 15;26(10):2470-4. doi: 10.1016/j.bmcl.2016.03.105.

PMID: 27055941

 

mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production.

Chen F, Cao A, Yao S, Evans-Marin HL, Liu H, Wu W, Carlsen ED, Dann SM, Soong L, Sun J, Zhao Q, Cong Y.

J Immunol. 2016 May 15;196(10):4390-9. doi: 10.4049/jimmunol.1501541.

PMID: 27067005

 

Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals.

Broce S, Hensley L, Sato T, Lehrer-Graiwer J, Essrich C, Edwards KJ, Pajda J, Davis CJ, Bhadresh R, Hurt CR, Freeman B, Lingappa VR, Kelleher CA, Karpuj MV.

Biol Direct. 2016 May 14;11:25. doi: 10.1186/s13062-016-0126-5.

PMID: 27179769

 

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents.

Qin T, Cornella J, Li C, Malins LR, Edwards JT, Kawamura S, Maxwell BD, Eastgate MD, Baran PS.

Science. 2016 May 13;352(6287):801-5. doi: 10.1126/science.aaf6123.

PMID: 27103669

 

Use of Chronic Medications Among Patients with Non-Valvular Atrial Fibrillation.

Kocis PT, Liu G, Makenbaeva D, Trocio J, Velott D, Trainer JB, Abdulsattar Y, Molina MI, Leslie DL.

Drugs Real World Outcomes. 2016 May 10;3(2):165-173.

PMID: 27398295

 

Scalable and sustainable electrochemical allylic C-H oxidation.

Horn EJ, Rosen BR, Chen Y, Tang J, Chen K, Eastgate MD, Baran PS.

Nature. 2016 May 5;533(7601):77-81. doi: 10.1038/nature17431.

PMID: 27096371

 

Exploring a new ultrasound score as a clinical predictive tool in patients with rheumatoid arthritis starting abatacept: results from the APPRAISE study.

D'Agostino MA, Boers M, Wakefield RJ, Berner Hammer H, Vittecoq O, Filippou G, Balint P, Möller I, Iagnocco A, Naredo E, Østergaard M, Gaillez C, Le Bars M.

RMD Open. 2016 May 5;2(1):e000237. doi: 10.1136/rmdopen-2015-000237.

PMID: 27175297

 

Erratum to: Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis.

Simon TA, Thompson A, Gandhi KK, Hochberg MC, Suissa S.

Arthritis Res Ther. 2016 May 4;18(1):100. No abstract available.

PMID: 27146822

 

Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity.

Tebben AJ, Ruzanov M, Gao M, Xie D, Kiefer SE, Yan C, Newitt JA, Zhang L, Kim K, Lu H, Kopcho LM, Sheriff S.

Acta Crystallogr D Struct Biol. 2016 May;72(Pt 5):658-74. doi: 10.1107/S2059798316003624.

PMID: 27139629

 

Impact of Disease Duration on the Effects of Pramlintide in Type 1 Diabetes: A Post Hoc Analysis of Three Clinical Trials.

Herrmann K, Brunell SC, Li Y, Zhou M, Maggs DG.

Adv Ther. 2016 May;33(5):848-61. doi: 10.1007/s12325-016-0326-5.

PMID: 27071768

 

History of bleeding and outcomes with apixaban versus warfarin in patients with atrial fibrillation in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial.

De Caterina R, Andersson U, Alexander JH, Al-Khatib SM, Bahit MC, Goto S, Hanna M, Held C, Hohnloser S, Hylek EM, Lanas F, Lopes RD, López-Sendón J, Renda G, Horowitz J, Granger CB, Wallentin L; ARISTOTLE Investigators..

Am Heart J. 2016 May;175:175-83. doi: 10.1016/j.ahj.2016.01.005.

PMID: 27179738

 

 LC-quadrupole/Orbitrap high-resolution mass spectrometry enables stable isotope-resolved simultaneous quantification and ¹³C-isotopic labeling of acyl-coenzyme A thioesters.

Frey AJ, Feldman DR, Trefely S, Worth AJ, Basu SS, Snyder NW.

Anal Bioanal Chem. 2016 May;408(13):3651-8. doi: 10.1007/s00216-016-9448-5.

PMID: 26968563

 

Traditional Cardiovascular Disease Risk Factor Management in Rheumatoid Arthritis Compared to Matched Nonrheumatoid Arthritis in a US Managed Care Setting.

An J, Cheetham TC, Reynolds K, Alemao E, Kawabata H, Liao KP, Solomon DH.

Arthritis Care Res (Hoboken). 2016 May;68(5):629-37. doi: 10.1002/acr.22740.

PMID: 26414069

 

Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF₁) receptor antagonists.

Ahuja VT, Hartz RA, Molski TF, Mattson GK, Lentz KA, Grace JE Jr, Lodge NJ, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2184-7. doi: 10.1016/j.bmcl.2016.03.067.

PMID: 27020524

 

Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity.

Schiffer CA, Cortes JE, Hochhaus A, Saglio G, le Coutre P, Porkka K, Mustjoki S, Mohamed H, Shah NP.

Cancer. 2016 May 1;122(9):1398-407. doi: 10.1002/cncr.29933.

PMID: 26998677

 

Efficacy and prognostic factors of treatment retention with intravenous abatacept for rheumatoid arthritis: 24-month results from an international, prospective, real-world study.

Nüßlein HG, Alten R, Galeazzi M, Lorenz HM, Nurmohamed MT, Bensen WG, Burmester GR, Peter HH, Peichl P, Pavelka K, Chartier M, Poncet C, Rauch C, Le Bars M.

Clin Exp Rheumatol. 2016 May-Jun;34(3):489-99.

PMID: 26966919

 

Network meta-analysis of treatments for type 2 diabetes mellitus following failure with metformin plus sulfonylurea.

Lozano-Ortega G, Goring S, Bennett HA, Bergenheim K, Sternhufvud C, Mukherjee J.

Curr Med Res Opin. 2016 May;32(5):807-16. doi: 10.1185/03007995.2015.1135110.

PMID: 26700585

 

Cardiovascular Risk Factor Targets and Cardiovascular Disease Event Risk in Diabetes: A Pooling Project of the Atherosclerosis Risk in Communities Study, Multi-Ethnic Study of Atherosclerosis, and Jackson Heart Study.

Wong ND, Zhao Y, Patel R, Patao C, Malik S, Bertoni AG, Correa A, Folsom AR, Kachroo S, Mukherjee J, Taylor H, Selvin E.

Diabetes Care. 2016 May;39(5):668-76. doi: 10.2337/dc15-2439.

PMID: 27208374

 

Characterization of antibody-drug conjugates by mass spectrometry: advances and future trends.

Huang RY, Chen G.

Drug Discov Today. 2016 May;21(5):850-5. doi: 10.1016/j.drudis.2016.04.004. Review.

PMID: 27080148

 

Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.

Kraynov E, Kamath AV, Walles M, Tarcsa E, Deslandes A, Iyer RA, Datta-Mannan A, Sriraman P, Bairlein M, Yang JJ, Barfield M, Xiao G, Escandon E, Wang W, Rock DA, Chemuturi NV, Moore DJ.

Drug Metab Dispos. 2016 May;44(5):617-23. doi: 10.1124/dmd.115.068049. Review.

PMID: 26669328

 

Use of acute and chronic ecotoxicity data in environmental risk assessment of pharmaceuticals.

Vestel J, Caldwell DJ, Constantine L, D'Aco VJ, Davidson T, Dolan DG, Millard SP, Murray-Smith R, Parke NJ, Ryan JJ, Straub JO, Wilson P.

Environ Toxicol Chem. 2016 May;35(5):1201-12. doi: 10.1002/etc.3260.

PMID: 26403382

 

Cost-effectiveness analysis of apixaban compared to low-molecularweight heparins and vitamin k antagonists for treatment and secondary prevention of venous thromboembolism.

Elías I, Oyagüez I, Alvarez-Sala LA, García-Bragado F, Navarro A, González P, De Andrés-Nogales F, Soto J.

Farm Hosp. 2016 May 1;40(3):187-208. doi: 10.7399/fh.2016.40.3.10461.

PMID: 27145388

 

Daclatasvir, sofosbuvir, and ribavirin for hepatitis C virus genotype 3 and advanced liver disease: A randomized phase III study (ALLY-3+).

Leroy V, Angus P, Bronowicki JP, Dore GJ, Hezode C, Pianko S, Pol S, Stuart K, Tse E, McPhee F, Bhore R, Jimenez-Exposito MJ, Thompson AJ.

Hepatology. 2016 May;63(5):1430-41. doi: 10.1002/hep.28473.

PMID: 26822022

 

Daclatasvir with sofosbuvir and ribavirin for hepatitis C virus infection with advanced cirrhosis or post-liver transplantation recurrence.

Poordad F, Schiff ER, Vierling JM, Landis C, Fontana RJ, Yang R, McPhee F, Hughes EA, Noviello S, Swenson ES.

Hepatology. 2016 May;63(5):1493-505. doi: 10.1002/hep.28446.

PMID: 26754432

 

Exploitation of the Ornithine Effect Enhances Characterization of Stapled and Cyclic Peptides.

Crittenden CM, Parker WR, Jenner ZB, Bruns KA, Akin LD, McGee WM, Ciccimaro E, Brodbelt JS.

J Am Soc Mass Spectrom. 2016 May;27(5):856-63. doi: 10.1007/s13361-016-1355-7.

PMID: 26864791

 

Response to Letter to the Editor From Drs. Stöllberger and Finsterer: Original Publication: "Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, and Safety of Apixaban".

Frost C, Chang M, Yu Z, Shenker A, Wang J, Pursley J, Byon W, Boyd RA, LaCreta F.

J Clin Pharmacol. 2016 May;56(5):648-9. doi: 10.1002/jcph.687. No abstract available.

PMID: 27088780

 

Effect of renal impairment on the pharmacokinetics, pharmacodynamics, and safety of apixaban.

Chang M, Yu Z, Shenker A, Wang J, Pursley J, Byon W, Boyd RA, LaCreta F, Frost CE.

J Clin Pharmacol. 2016 May;56(5):637-45. doi: 10.1002/jcph.633.

PMID: 26358690

 

Pharmacokinetics, pharmacodynamics, and safety of apixaban in subjects with end-stage renal disease on hemodialysis.

Wang X, Tirucherai G, Marbury TC, Wang J, Chang M, Zhang D, Song Y, Pursley J, Boyd RA, Frost C.

J Clin Pharmacol. 2016 May;56(5):628-36. doi: 10.1002/jcph.628.

PMID: 26331581

 

Daclatasvir + asunaprevir versus sofosbuvir/ledipasvir for hepatitis C genotype 1 in Japanese patients: an indirect comparison.

Swallow E, Kelley C, Signorovitch J, Wygant G, McPhee F.

J Comp Eff Res. 2016 May;5(3):273-9. doi: 10.2217/cer.15.69.

PMID: 26793987

 

Peginterferon lambda for the treatment of HBeAg-positive chronic hepatitis B: A randomized phase 2b study (LIRA-B).

Chan HL, Ahn SH, Chang TT, Peng CY, Wong D, Coffin CS, Lim SG, Chen PJ, Janssen HL, Marcellin P, Serfaty L, Zeuzem S, Cohen D, Critelli L, Xu D, Wind-Rotolo M, Cooney E; LIRA-B Study Team..

J Hepatol. 2016 May;64(5):1011-9. doi: 10.1016/j.jhep.2015.12.018.

PMID: 26739688

 

Association Between Weight Change, Clinical Outcomes, and Health Care Costs in Patients with Type 2 Diabetes.

Mukherjee J, Sternhufvud C, Smith N, Bell K, Stott-Miller M, McMorrow D, Johnston S.

J Manag Care Spec Pharm. 2016 May;22(5):449-66. doi: 10.18553/jmcp.2016.22.5.449.

PMID: 27123909

 

 The function and performance of aqueous aerosol devices for inhalation therapy.

Carvalho TC, McConville JT.

J Pharm Pharmacol. 2016 May;68(5):556-78. doi: 10.1111/jphp.12541. Review.

PMID: 27061412

 

Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species.

Shen H, Dai J, Liu T, Cheng Y, Chen W, Freeden C, Zhang Y, Humphreys WG, Marathe P, Lai Y.

J Pharmacol Exp Ther. 2016 May;357(2):382-93. doi: 10.1124/jpet.116.232066.

PMID: 26907622

 

Retrospective Evaluation of Low-pH Viral Inactivation and Viral Filtration Data from a Multiple Company Collaboration.

Mattila J, Clark M, Liu S, Pieracci J, Gervais TR, Wilson E, Galperina O, Li X, Roush D, Zoeller K, Brough H, Simpson-Platre C.

PDA J Pharm Sci Technol. 2016 May-Jun;70(3):293-9. doi: 10.5731/pdajpst.2016.006478.

PMID: 27020645

 

A Roadmap for the Implementation of Continued Process Verification.

Boyer M, Gampfer J, Zamamiri A, Payne R.

PDA J Pharm Sci Technol. 2016 May-Jun;70(3):282-92. doi: 10.5731/pdajpst.2015.006395.

PMID: 27020644

 

Investigation of Air-Liquid Interface Rings in Buffer Preparation Vessels: the Role of Slip Agents.

Shi T, Ding W, Kessler DW, De Mas N, Weaver DG, Pathirana C, Martin RD, Mackin NA, Casati M, Miller SA, Pla IA.

PDA J Pharm Sci Technol. 2016 May-Jun;70(3):272-81. doi: 10.5731/pdajpst.2015.005736.

PMID: 26797969

 

Characterization of Supersaturated Danazol Solutions - Impact of Polymers on Solution Properties and Phase Transitions.

Jackson MJ, Kestur US, Hussain MA, Taylor LS.

Pharm Res. 2016 May;33(5):1276-88. doi: 10.1007/s11095-016-1871-y.

PMID: 26892947

 

Osmotic diuresis with SGLT2 inhibition: analysis of events related to volume reduction in dapagliflozin clinical trials.

Johnsson K, Johnsson E, Mansfield TA, Yavin Y, Ptaszynska A, Parikh SJ.

Postgrad Med. 2016 May;128(4):346-55. doi: 10.1080/00325481.2016.1153941.

PMID: 26878357

 

Cost analysis of biologic drugs in rheumatoid arthritis first line treatment after methotrexate failure according to patients' body weight.

Román Ivorra JA, Ivorra J, Monte-Boquet E, Canal C, Oyagüez I, Gómez-Barrera M.

Reumatol Clin. 2016 May-Jun;12(3):123-9. doi: 10.1016/j.reuma.2015.07.008. English, Spanish.

PMID: 26362842

 

Cardiovascular risk factor management in patients with RA compared to matched non-RA patients.

Alemao E, Cawston H, Bourhis F, Al M, Rutten-van Mölken MP, Liao KP, Solomon DH.

Rheumatology (Oxford). 2016 May;55(5):809-16. doi: 10.1093/rheumatology/kev427.

PMID: 26705329

  

Evolution of the microstructure during the process of consolidation and bonding in soft granular solids.

Yohannes B, Gonzalez M, Abebe A, Sprockel O, Nikfar F, Kiang S, Cuitiño AM.

Int J Pharm. 2016 Apr 30;503(1-2):68-77. doi: 10.1016/j.ijpharm.2016.02.032.

PMID: 26902721

 

Atropisomer Control in Macrocyclic Factor VIIa Inhibitors.

Glunz PW, Mueller L, Cheney DL, Ladziata V, Zou Y, Wurtz NR, Wei A, Wong PC, Wexler RR, Priestley ES.

J Med Chem. 2016 Apr 28;59(8):4007-18. doi: 10.1021/acs.jmedchem.6b00244.

PMID: 27015008

 

The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes.

Sabareesan AT, Singh J, Roy S, Udgaonkar JB, Mathew MK.

Biophys J. 2016 Apr 26;110(8):1766-76. doi: 10.1016/j.bpj.2016.03.017.

PMID: 27119637

 

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

Regueiro-Ren A, Liu Z, Chen Y, Sin N, Sit SY, Swidorski JJ, Chen J, Venables BL, Zhu J, Nowicka-Sans B, Protack T, Lin Z, Terry B, Samanta H, Zhang S, Li Z, Beno BR, Huang XS, Rahematpura S, Parker DD, Haskell R, Jenkins S, Santone KS, Cockett MI, Krystal M, Meanwell NA, Hanumegowda U, Dicker IB.

ACS Med Chem Lett. 2016 Apr 22;7(6):568-72. doi: 10.1021/acsmedchemlett.6b00010.

PMID: 27326328

 

Model-Based Phase 3 Dose Selection for HIV-1 Attachment Inhibitor Prodrug BMS-663068 in HIV-1-Infected Patients: Population Pharmacokinetics/Pharmacodynamics of the Active Moiety, BMS-626529.

Landry I, Zhu L, Abu Tarif M, Hruska M, Sadler BM, Pitsiu M, Joshi S, Hanna GJ, Lataillade M, Boulton DW, Bertz RJ.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2782-9. doi: 10.1128/AAC.02503-15.

PMID: 26902761

 

PD-1 marks dysfunctional regulatory T cells in malignant gliomas.

Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA.

JCI Insight. 2016 Apr 21;1(5). pii: e85935.

PMID: 27182555

 

Attenuated total reflection-Fourier transform infrared spectroscopic imaging of pharmaceuticals in microfluidic devices.

Ewing AV, Clarke GS, Kazarian SG.

Biomicrofluidics. 2016 Apr 20;10(2):024125. doi: 10.1063/1.4946867.

PMID: 27158293

 

Reductions in disease activity in the AMPLE trial: clinical response by baseline disease duration.

Schiff M, Weinblatt ME, Valente R, Citera G, Maldonado M, Massarotti E, Yazici Y, Fleischmann R.

RMD Open. 2016 Apr 19;2(1):e000210. doi: 10.1136/rmdopen-2015-000210.

PMID: 27110385

 

 Toxicology Strategies for Drug Discovery - Present and Future: Introduction.

Humphreys WG, Will Y, Guengerich FP.

Chem Res Toxicol. 2016 Apr 18;29(4):437. doi: 10.1021/acs.chemrestox.6b00049. No abstract available.

PMID: 27087588

 

Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space.

Meanwell NA.

Chem Res Toxicol. 2016 Apr 18;29(4):564-616. doi: 10.1021/acs.chemrestox.6b00043. Review.

PMID: 26974882

 

Involvement of Drug Transporters in Organ Toxicity: The Fundamental Basis of Drug Discovery and Development.

Cheng Y, El-Kattan A, Zhang Y, Ray AS, Lai Y.

Chem Res Toxicol. 2016 Apr 18;29(4):545-63. doi: 10.1021/acs.chemrestox.5b00511. Review.

PMID: 26889774

 

In Vitro Developmental Toxicology Screens: A Report on the Progress of the Methodology and Future Applications.

Zhang C, Ball J, Panzica-Kelly J, Augustine-Rauch K.

Chem Res Toxicol. 2016 Apr 18;29(4):534-44. doi: 10.1021/acs.chemrestox.5b00458. Review.

PMID: 26766213

 

Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics.

Zheng N, Zeng J, Manney A, Williams L, Aubry AF, Voronin K, Buzescu A, Zhang YJ, Allentoff A, Xu C, Shen H, Warner W, Arnold ME.

Anal Chim Acta. 2016 Apr 15;916:42-51. doi: 10.1016/j.aca.2016.02.017.

PMID: 27016437

 

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

Liu Z, Swidorski JJ, Nowicka-Sans B, Terry B, Protack T, Lin Z, Samanta H, Zhang S, Li Z, Parker DD, Rahematpura S, Jenkins S, Beno BR, Krystal M, Meanwell NA, Dicker IB, Regueiro-Ren A.

Bioorg Med Chem. 2016 Apr 15;24(8):1757-70. doi: 10.1016/j.bmc.2016.03.001.

PMID: 26968652

 

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.

Swidorski JJ, Liu Z, Sit SY, Chen J, Chen Y, Sin N, Venables BL, Parker DD, Nowicka-Sans B, Terry BJ, Protack T, Rahematpura S, Hanumegowda U, Jenkins S, Krystal M, Dicker IB, Meanwell NA, Regueiro-Ren A.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):1925-30. doi: 10.1016/j.bmcl.2016.03.019.

PMID: 26988305

 

Brief Report: Switch to Ritonavir-Boosted Atazanavir Plus Raltegravir in Virologically Suppressed Patients With HIV-1 Infection: A Randomized Pilot Study.

van Lunzen J, Pozniak A, Gatell JM, Antinori A, Klauck I, Serrano O, Baakili A, Osiyemi O, Sevinsky H, Girard PM.

J Acquir Immune Defic Syndr. 2016 Apr 15;71(5):538-43. doi: 10.1097/QAI.0000000000000904.

PMID: 26605505

 

Expedient Synthesis of Furo[2,3-d][1,3]thiazinamines and Pyrano[2,3-d][1,3]thiazinamines from Enones and Thiourea.

Wu YJ, Guernon J, Park H, Thompson LA.

J Org Chem. 2016 Apr 15;81(8):3386-90. doi: 10.1021/acs.joc.5b02705.

PMID: 27002691

 

Synergistic Catalysis: Pd(II) Catalyzed Oxidation of 1,4-Dihydroquinones in the Pd(II) Catalyzed 1,4-Oxidation of Cyclic 1,3-Dienes.

Zheng B, Schmidt MA, Eastgate MD.

J Org Chem. 2016 Apr 15;81(8):3112-8. doi: 10.1021/acs.joc.5b02769.

PMID: 26925844

 

The Human Vaccines Project: A roadmap for cancer vaccine development.

Romero P, Banchereau J, Bhardwaj N, Cockett M, Disis ML, Dranoff G, Gilboa E, Hammond SA, Hershberg R, Korman AJ, Kvistborg P, Melief C, Mellman I, Palucka AK, Redchenko I, Robins H, Sallusto F, Schenkelberg T, Schoenberger S, Sosman J, Türeci Ö, Van den Eynde B, Koff W, Coukos G.

Sci Transl Med. 2016 Apr 13;8(334):334ps9. doi: 10.1126/scitranslmed.aaf0685. Review.

PMID: 27075624

 

Understanding CKD among patients with T2DM: prevalence, temporal trends, and treatment patterns-NHANES 2007-2012.

Wu B, Bell K, Stanford A, Kern DM, Tunceli O, Vupputuri S, Kalsekar I, Willey V.

BMJ Open Diabetes Res Care. 2016 Apr 11;4(1):e000154. doi: 10.1136/bmjdrc-2015-000154.

PMID: 27110365

 

Long-term drug costs per life-month gained associated with first-line treatments for unresectable or metastatic melanoma.

Liu JS, Rao S.

Exp Hematol Oncol. 2016 Apr 11;5:9. doi: 10.1186/s40164-016-0039-0.

PMID: 27069772

 

Transthyretin Suppresses Amyloid-β Secretion by Interfering with Processing of the Amyloid-β Protein Precursor.

Li X, Song Y, Sanders CR, Buxbaum JN.

J Alzheimers Dis. 2016 Apr 8;52(4):1263-75. doi: 10.3233/JAD-160033.

PMID: 27079720

 

 Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.

Adams PD, Aertgeerts K, Bauer C, Bell JA, Berman HM, Bhat TN, Blaney JM, Bolton E, Bricogne G, Brown D, Burley SK, Case DA, Clark KL, Darden T, Emsley P, Feher VA, Feng Z, Groom CR, Harris SF, Hendle J, Holder T, Joachimiak A, Kleywegt GJ, Krojer T, Marcotrigiano J, Mark AE, Markley JL, Miller M, Minor W, Montelione GT, Murshudov G, Nakagawa A, Nakamura H, Nicholls A, Nicklaus M, Nolte RT, Padyana AK, Peishoff CE, Pieniazek S, Read RJ, Shao C, Sheriff S, Smart O, Soisson S, Spurlino J, Stouch T, Svobodova R, Tempel W, Terwilliger TC, Tronrud D, Velankar S, Ward SC, Warren GL, Westbrook JD, Williams P, Yang H, Young J.

Structure. 2016 Apr 5;24(4):502-8. doi: 10.1016/j.str.2016.02.017.

PMID: 27050687

 

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

Shi Y, Li J, Kennedy LJ, Tao S, Hernández AS, Lai Z, Chen S, Wong H, Zhu J, Trehan A, Lim NK, Zhang H, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M, Muckelbauer J, Chang C, Krystek SR, Li YX, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA.

ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. doi: 10.1021/acsmedchemlett.6b00033.

PMID: 27326332

 

Rationale and design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) trial.

Holman RR, Bethel MA, George J, Sourij H, Doran Z, Keenan J, Khurmi NS, Mentz RJ, Oulhaj A, Buse JB, Chan JC, Iqbal N, Kundu S, Maggioni AP, Marso SP, Öhman P, Pencina MJ, Poulter N, Porter LE, Ramachandran A, Zinman B, Hernandez AF.

Am Heart J. 2016 Apr;174:103-10. doi: 10.1016/j.ahj.2015.12.009.

PMID: 26995376

 

Effect of Rifampin on the Pharmacokinetics of Apixaban, an Oral Direct Inhibitor of Factor Xa.

Vakkalagadda B, Frost C, Byon W, Boyd RA, Wang J, Zhang D, Yu Z, Dias C, Shenker A, LaCreta F.

Am J Cardiovasc Drugs. 2016 Apr;16(2):119-27. doi: 10.1007/s40256-015-0157-9.

PMID: 26749408

 

CD57(+) CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection.

Espinosa J, Herr F, Tharp G, Bosinger S, Song M, Farris AB 3rd, George R, Cheeseman J, Stempora L, Townsend R, Durrbach A, Kirk AD.

Am J Transplant. 2016 Apr;16(4):1102-12. doi: 10.1111/ajt.13613.

PMID: 26603381

 

Impact of baseline anti-cyclic citrullinated peptide-2 antibody concentration on efficacy outcomes following treatment with subcutaneous abatacept or adalimumab: 2-year results from the AMPLE trial.

Sokolove J, Schiff M, Fleischmann R, Weinblatt ME, Connolly SE, Johnsen A, Zhu J, Maldonado MA, Patel S, Robinson WH.

Ann Rheum Dis. 2016 Apr;75(4):709-14. doi: 10.1136/annrheumdis-2015-207942.

PMID: 26359449

 

Techniques for quantitative LC-MS/MS analysis of protein therapeutics: advances in enzyme digestion and immunocapture.

Fung EN, Bryan P, Kozhich A.

Bioanalysis. 2016 Apr;8(8):847-56. doi: 10.4155/bio.16.24. Review.

PMID: 27005854

 

Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase.

Chupak LS, Zheng X, Hu S, Huang Y, Ding M, Lewis MA, Westphal RS, Blat Y, McClure A, Gentles RG.

Bioorg Med Chem. 2016 Apr 1;24(7):1455-68. doi: 10.1016/j.bmc.2016.02.006.

PMID: 26917221

 

Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives.

Singh N, Arunkumar A, Chollangi S, Tan ZG, Borys M, Li ZJ.

Biotechnol Bioeng. 2016 Apr;113(4):698-716. doi: 10.1002/bit.25810. Review.

PMID: 26302443

 

De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute.

Mellman I, Hubbard-Lucey VM, Tontonoz MJ, Kalos MD, Chen DS, Allison JP, Drake CG, Levitsky H, Lonberg N, van der Burg SH, Fearon DT, Wherry EJ, Lowy I, Vonderheide RH, Hwu P.

Cancer Immunol Res. 2016 Apr;4(4):279-88. doi: 10.1158/2326-6066.CIR-16-0045. Review.

PMID: 27036972

 

Diagnosis, monitoring and management of immune-related adverse drug reactions of anti-PD-1 antibody therapy.

Eigentler TK, Hassel JC, Berking C, Aberle J, Bachmann O, Grünwald V, Kähler KC, Loquai C, Reinmuth N, Steins M, Zimmer L, Sendl A, Gutzmer R.

Cancer Treat Rev. 2016 Apr;45:7-18. doi: 10.1016/j.ctrv.2016.02.003. Review.

PMID: 26922661

 

The Association Between Bleeding and the Incidence of Warfarin Discontinuation in Patients with Atrial Fibrillation.

Simon TA, Pan X, Kawabata H, Huang HY, Azoulay L.

Cardiovasc Ther. 2016 Apr;34(2):94-9. doi: 10.1111/1755-5922.12174.

PMID: 26763662

 

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach.

Vildhede A, Mateus A, Khan EK, Lai Y, Karlgren M, Artursson P, Kjellsson MC.

Drug Metab Dispos. 2016 Apr;44(4):505-16. doi: 10.1124/dmd.115.066746.

PMID: 26842596

 

Burden of stroke and other cardiovascular complications in patients with atrial fibrillation hospitalized in France.

Cotté FE, Chaize G, Gaudin AF, Samson A, Vainchtock A, Fauchier L.

Europace. 2016 Apr;18(4):501-7. doi: 10.1093/europace/euv248.

PMID: 26718532

 

Multimodal imaging analysis of an orthotopic head and neck cancer mouse model and application of anti-CD137 tumor immune therapy.

Vahle AK, Hermann S, Schäfers M, Wildner M, Kerem A, Öztürk E, Jure-Kunkel M, Franklin C, Lang S, Brandau S.

Head Neck. 2016 Apr;38(4):542-9. doi: 10.1002/hed.23929.

PMID: 25482887

 

Biomarkers of inflammation and risk of cardiovascular events in anticoagulated patients with atrial fibrillation.

Hijazi Z, Aulin J, Andersson U, Alexander JH, Gersh B, Granger CB, Hanna M, Horowitz J, Hylek EM, Lopes RD, Siegbahn A, Wallentin L; ARISTOTLE Investigators..

Heart. 2016 Apr;102(7):508-17. doi: 10.1136/heartjnl-2015-308887.

PMID: 26839066

 

Eldelumab [Anti-IP-10] Induction Therapy for Ulcerative Colitis: A Randomised, Placebo-Controlled, Phase 2b Study.

Sandborn WJ, Colombel JF, Ghosh S, Sands BE, Dryden G, Hébuterne X, Leong RW, Bressler B, Ullman T, Lakatos PL, Reinisch W, Xu LA, Luo A.

J Crohns Colitis. 2016 Apr;10(4):418-28. doi: 10.1093/ecco-jcc/jjv224.

PMID: 26721935

 

Synthesis of isotopically labeled daclatasvir for use in human clinical studies.

Easter JA, Burrell RC, Bonacorsi SJ Jr.

J Labelled Comp Radiopharm. 2016 Apr;59(4):164-70. doi: 10.1002/jlcr.3386.

PMID: 26968868

 

Lost Labor Productivity Costs of Prostate Cancer to Patients and Their Spouses: Evidence From US National Survey Data.

Rizzo JA, Zyczynski TM, Chen J, Mallow PJ, Trudel GC, Penrod JR.

J Occup Environ Med. 2016 Apr;58(4):351-8. doi: 10.1097/JOM.0000000000000621.

PMID: 27058474

 

Dehydration and Stabilization of a Reactive Tertiary Hydroxyl Group in Solid Oral Dosage Forms of BMS-779788.

Adams ML, Sharma V, Gokhale M, Huang Y, Stefanski K, Su C, Hussain MA.

J Pharm Sci. 2016 Apr;105(4):1478-88. doi: 10.1016/j.xphs.2015.12.028.

PMID: 26921118

 

193TiP: CheckMate 171: A multicenter phase 2 trial of nivolumab (nivo) in patients (pts) with stage IIIB/IV squamous cell (SQ) NSCLC who have received ≥1 prior systemic treatment.

Felip E, Van Meerbeeck J, Wolf J, Ardizzoni A, Li A, Srinivasan S, Popat S.

J Thorac Oncol. 2016 Apr;11(4 Suppl):S141. doi: 10.1016/S1556-0864(16)30302-1. No abstract available.

PMID: 27198331

 

137O: Nivolumab in patients (pts) with advanced refractory squamous (SQ) non-small cell lung cancer (NSCLC): 2-year follow-up from CheckMate 063 and exploratory cytokine profling analyses.

Lena H, Rizvi NA, Wolf J, Cappuzzo F, Zalcman G, Baas P, Mazieres J, Farsaci B, Blackwood-Chirchir MA, Ramalingam S.

J Thorac Oncol. 2016 Apr;11(4 Suppl):S115-6. doi: 10.1016/S1556-0864(16)30247-7. No abstract available.

PMID: 27198275

 

The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys.

Wong PC, Watson C, Crain EJ.

J Thromb Thrombolysis. 2016 Apr;41(3):514-21. doi: 10.1007/s11239-015-1302-7.

PMID: 26660522

 

Investigation of Color in a Fusion Protein Using Advanced Analytical Techniques: Delineating Contributions from Oxidation Products and Process Related Impurities.

Song H, Xu J, Jin M, Huang C, Bongers J, Bai H, Wu W, Ludwig R, Li Z, Tao L, Das TK.

Pharm Res. 2016 Apr;33(4):932-41. doi: 10.1007/s11095-015-1839-3.

PMID: 26658915

 

The qEEG Signature of Selective NMDA NR2B Negative Allosteric Modulators; A Potential Translational Biomarker for Drug Development.

Keavy D, Bristow LJ, Sivarao DV, Batchelder M, King D, Thangathirupathy S, Macor JE, Weed MR.

PLoS One. 2016 Apr 1;11(4):e0152729. doi: 10.1371/journal.pone.0152729.

PMID: 27035340

 

The Use of Minipigs for Preclinical Safety Assessment by the Pharmaceutical Industry: Results of an IQ DruSafe Minipig Survey.

Colleton C, Brewster D, Chester A, Clarke DO, Heining P, Olaharski A, Graziano M.

Toxicol Pathol. 2016 Apr;44(3):458-66. doi: 10.1177/0192623315617562.

PMID: 27006130

 

Risk of Cardiovascular Events Among Patients Initiating Efavirenz-Containing Versus Efavirenz-Free Antiretroviral Regimens.

Rosenblatt L, Farr AM, Johnston SS, Nkhoma ET.

Open Forum Infect Dis. 2016 Mar 30;3(2):ofw061. doi: 10.1093/ofid/ofw061.

PMID: 27186585

 

Ensemble Modeling and Intracellular Aggregation of an Engineered Immunoglobulin-Like Domain.

Trainor K, Gingras Z, Shillingford C, Malakian H, Gosselin M, Lipovšek D, Meiering EM.

J Mol Biol. 2016 Mar 27;428(6):1365-74. doi: 10.1016/j.jmb.2016.02.016.

PMID: 26903090

 

Quantitation of repaglinide and metabolites in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.

Chen W, Wang L, Van Berkel GJ, Kertesz V, Gan J.

J Chromatogr A. 2016 Mar 25;1439:137-43. doi: 10.1016/j.chroma.2015.10.093.

PMID: 26589943

 

Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.

Watterson SH, Guo J, Spergel SH, Langevine CM, Moquin RV, Shen DR, Yarde M, Cvijic ME, Banas D, Liu R, Suchard SJ, Gillooly K, Taylor T, Rex-Rabe S, Shuster DJ, McIntyre KW, Cornelius G, D'Arienzo C, Marino A, Balimane P, Warrack B, Salter-Cid L, McKinnon M, Barrish JC, Carter PH, Pitts WJ, Xie J, Dyckman AJ.

J Med Chem. 2016 Mar 24;59(6):2820-40. doi: 10.1021/acs.jmedchem.6b00089.

PMID: 26924461

 

Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target.

Chaudhry C, Davis J, Zhang Y, Posy S, Lei M, Shen H, Yan C, Devaux B, Zhang L, Blat Y, Metzler W, Borzilleri RM, Talbott RL.

Anal Biochem. 2016 Mar 15;497:8-17. doi: 10.1016/j.ab.2015.11.026.

PMID: 26743718

 

Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators.

Wu YJ, Zhang Y, Toyn JH, Macor JE, Thompson LA.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1554-7. doi: 10.1016/j.bmcl.2016.02.016.

PMID: 26898338

 

Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.

Zhuo X, Cantone JL, Wang Y, Leet JE, Drexler DM, Yeung KS, Huang XS, Eastman KJ, Parcella KE, Mosure KW, Soars MG, Kadow JF, Johnson BM.

Drug Metab Dispos. 2016 Mar 9. pii: dmd.115.069062. [Epub ahead of print]

PMID: 26961241

 

Evaluation of the Microcentrifuge Dissolution Method as a Tool for Spray-Dried Dispersion.

Wu B, Li J, Wang Y.

AAPS J. 2016 Mar;18(2):346-53. doi: 10.1208/s12248-016-9872-7.

PMID: 26831250

 

Pre-existing Antibody: Biotherapeutic Modality-Based Review.

Gorovits B, Clements-Egan A, Birchler M, Liang M, Myler H, Peng K, Purushothama S, Rajadhyaksha M, Salazar-Fontana L, Sung C, Xue L.

AAPS J. 2016 Mar;18(2):311-20. doi: 10.1208/s12248-016-9878-1. Review.

PMID: 26821802

 

Assessment of low-dose i.v. ketamine infusions for adjunctive analgesia.

Kator S, Correll DJ, Ou JY, Levinson R, Noronha GN, Adams CD.

Am J Health Syst Pharm. 2016 Mar 1;73(5 Suppl 1):S22-9. doi: 10.2146/ajhp150367.

PMID: 26896522

 

Pharmacologic Prophylaxis for Venous Thromboembolism Among Patients With Total Joint Replacement: An Electronic Medical Records Study.

Rosenman M, Liu X, Phatak H, Qi R, Teal E, Nisi D, Liu LZ, Parr JA.

Am J Ther. 2016 Mar-Apr;23(2):e336-44. doi: 10.1097/01.mjt.0000433946.78535.84.

PMID: 26736015

 

Pharmacological Prophylaxis for Venous Thromboembolism Among Hospitalized Patients With Acute Medical Illness: An Electronic Medical Records Study.

Rosenman M, Liu X, Phatak H, Qi R, Teal E, Nisi D, Liu LZ, Ramacciotti E.

Am J Ther. 2016 Mar-Apr;23(2):e328-35. doi: 10.1097/01.mjt.0000433945.70911.7c.

PMID: 26720163

 

Effects of Achieving Target Measures in Rheumatoid Arthritis on Functional Status, Quality of Life, and Resource Utilization: Analysis of Clinical Practice Data.

Alemao E, Joo S, Kawabata H, Al MJ, Allison PD, Rutten-van Mölken MP, Frits ML, Iannaccone CK, Shadick NA, Weinblatt ME.

Arthritis Care Res (Hoboken). 2016 Mar;68(3):308-17. doi: 10.1002/acr.22678.

PMID: 26238974

 

Abatacept Inhibition of T Cell Priming in Mice by Induction of a Unique Transcriptional Profile That Reduces Their Ability to Activate Antigen-Presenting Cells.

Patakas A, Ji RR, Weir W, Connolly SE, Benson RA, Nadler SG, Brewer JM, McInnes IB, Garside P.

Arthritis Rheumatol. 2016 Mar;68(3):627-38. doi: 10.1002/art.39470.

PMID: 26473409

 

Validation of an integrated series of ligand-binding assays for the quantitative determination of antibody-drug conjugates in biological matrices.

Myler H, Rangan VS, Kozhich A, Hoffpauir B, Dail D, Cummings J, Saewert M, Manney A, Liu A, Rao C, Wang J, Pillutla R, DeSilva B.

Bioanalysis. 2016 Mar;8(6):519-31. doi: 10.4155/bio.16.13.

PMID: 26915587

 

Industry view on the relative importance of "clonality" of biopharmaceutical-producing cell lines.

Frye C, Deshpande R, Estes S, Francissen K, Joly J, Lubiniecki A, Munro T, Russell R, Wang T, Anderson K.

Biologicals. 2016 Mar;44(2):117-22. doi: 10.1016/j.biologicals.2016.01.001. Review.

PMID: 26852257

 

Design and optimization of tricyclic gamma-secretase modulators.

Shi J, Zuev D, Xu L, Lentz KA, Grace JE, Toyn JH, Olson RE, Macor JE, Thompson LA.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1498-502. doi: 10.1016/j.bmcl.2015.06.020.

PMID: 26848108

 

Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans.

Wang H, Rangan VS, Sung MC, Passmore D, Kempe T, Wang X, Thevanayagam L, Pan C, Rao C, Srinivasan M, Zhang Q, Gangwar S, Deshpande S, Cardarelli P, Marathe P, Yang Z.

Biopharm Drug Dispos. 2016 Mar;37(2):93-106. doi: 10.1002/bdd.1953.

PMID: 25869904

 

Evaluation of the potential for QTc prolongation in patients with solid tumors receiving nivolumab.

Agrawal S, Waxman I, Lambert A, Roy A, Darbenzio R.

Cancer Chemother Pharmacol. 2016 Mar;77(3):635-41. doi: 10.1007/s00280-016-2980-3.

PMID: 26861469

 

Pharmacokinetics and Safety of Elotuzumab Combined With Lenalidomide and Dexamethasone in Patients With Multiple Myeloma and Various Levels of Renal Impairment: Results of a Phase Ib Study.

Berdeja J, Jagannath S, Zonder J, Badros A, Kaufman JL, Manges R, Gupta M, Tendolkar A, Lynch M, Bleickardt E, Paliwal P, Vij R.

Clin Lymphoma Myeloma Leuk. 2016 Mar;16(3):129-38. doi: 10.1016/j.clml.2015.12.007.

PMID :26795075

 

Cost-effectiveness of Apixaban Versus Other Oral Anticoagulants for the Initial Treatment of Venous Thromboembolism and Prevention of Recurrence.

Lanitis T, Leipold R, Hamilton M, Rublee D, Quon P, Browne C, Cohen AT.

Clin Ther. 2016 Mar;38(3):478-93.e1-16. doi: 10.1016/j.clinthera.2016.01.020.

PMID: 26922297

 

Saxagliptin improves glycaemic control and C-peptide secretion in latent autoimmune diabetes in adults (LADA).

Buzzetti R, Pozzilli P, Frederich R, Iqbal N, Hirshberg B.

Diabetes Metab Res Rev. 2016 Mar;32(3):289-96. doi: 10.1002/dmrr.2717.

PMID: 26385269

 

Comparison of the pharmacokinetics and pharmacodynamics of dapagliflozin in patients with type 1 versus type 2 diabetes mellitus.

Tang W, Leil TA, Johnsson E, Boulton DW, LaCreta F.

Diabetes Obes Metab. 2016 Mar;18(3):236-40. doi: 10.1111/dom.12594.

PMID: 26510924

 

Effect of the SGLT2 Inhibitor Dapagliflozin on Potassium Levels in Patients with Type 2 Diabetes Mellitus: A Pooled Analysis.

Yavin Y, Mansfield TA, Ptaszynska A, Johnsson K, Parikh S, Johnsson E.

Diabetes Ther. 2016 Mar;7(1):125-37. doi: 10.1007/s13300-015-0150-y.

PMID: 26758563

 

Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.

Zhang Y, Han YH, Putluru SP, Matta MK, Kole P, Mandlekar S, Furlong MT, Liu T, Iyer RA, Marathe P, Yang Z, Lai Y, Rodrigues AD.

Drug Metab Dispos. 2016 Mar;44(3):320-8. doi: 10.1124/dmd.115.066944.

PMID: 26714763

 

Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology.

Jackson N, Atar D, Borentain M, Breithardt G, van Eickels M, Endres M, Fraass U, Friede T, Hannachi H, Janmohamed S, Kreuzer J, Landray M, Lautsch D, Le Floch C, Mol P, Naci H, Samani NJ, Svensson A, Thorstensen C, Tijssen J, Vandzhura V, Zalewski A, Kirchhof P.

Eur Heart J. 2016 Mar 1;37(9):747-54. doi: 10.1093/eurheartj/ehv213. Review.

PMID: 26077039

 

Deciphering CD137 (4-1BB) signaling in T-cell costimulation for translation into successful cancer immunotherapy.

Sanchez-Paulete AR, Labiano S, Rodriguez-Ruiz ME, Azpilikueta A, Etxeberria I, Bolaños E, Lang V, Rodriguez M, Aznar MA, Jure-Kunkel M, Melero I.

Eur J Immunol. 2016 Mar;46(3):513-22. doi: 10.1002/eji.201445388. Review.

PMID: 26773716

 

Influence of temperature and relative humidity conditions on the pan coating of hydroxypropyl cellulose molded capsules.

Macchi E, Zema L, Pandey P, Gazzaniga A, Felton LA.

Eur J Pharm Biopharm. 2016 Mar;100:47-57. doi: 10.1016/j.ejpb.2015.11.021.

PMID: 26686650

 

Viral hepatitis screening guideline before biological drug use in rheumatic patients.

Karadağ Ö, Kaşifoğlu T, Özer B, Kaymakoğlu S, Kuş Y, İnanç M, Keser G, Kiraz S.

Eur J Rheumatol. 2016 Mar;3(1):25-28. Review.

PMID 27708965

 

Estimating the cost-effectiveness of daclatasvir plus asunaprevir in difficult to treat Japanese patients chronically infected with hepatitis C genotype 1b.

McEwan P, Ward T, Webster S, Yuan Y, Kalsekar A, Kamae I, Kobayashi M, Tang A, Kumada H.

Hepatol Res. 2016 Mar;46(5):423-33. doi: 10.1111/hepr.12570.

PMID: 26440999

 

Comparison of real-world acute care interventions (ACI) in patients (pts) with advanced non-small cell lung cancer (adv NSCLC) treated with chemotherapy versus targeted therapies.

Korytowsky B, Bhor M, Tuell K, Feinberg BA.

J Clin Oncol. 2016 Mar;34(7_suppl):37. doi: 10.1200/jco.2016.34.7_suppl.37.

PMID: 28152720

 

Daclatasvir + sofosbuvir versus standard of care for hepatitis C genotype 3: a matching-adjusted indirect comparison.

Swallow E, Song J, Yuan Y, Kalsekar A, Kelley C, Mu F, Kim S, Noviello S, Signorovitch J.

J Comp Eff Res. 2016 Mar;5(2):129-39. doi: 10.2217/cer.15.49.

PMID: 26390233

 

Relating Protein-Protein Interactions and Aggregation Rates From Low to High Concentrations.

Ghosh R, Calero-Rubio C, Saluja A, Roberts CJ.

J Pharm Sci. 2016 Mar;105(3):1086-96. doi: 10.1016/j.xphs.2016.01.004.

PMID: 26928400

 

An Approach to Mitigate Particle Formation on the Dilution of a Monoclonal Antibody Drug Product in an IV Administration Fluid.

Zheng S, Adams M, Mantri RV.

J Pharm Sci. 2016 Mar;105(3):1349-50. doi: 10.1016/j.xphs.2015.12.013.

PMID: 26886343

 

Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination.

Kieltyka K, McAuliffe B, Cianci C, Drexler DM, Shou W, Zhang J.

J Pharm Sci. 2016 Mar;105(3):1036-42. doi: 10.1016/S0022-3549(15)00177-X.

PMID: 26886323

 

Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: a randomised, double-blind, placebo-controlled, phase 3 study.

Weber MA, Mansfield TA, Cain VA, Iqbal N, Parikh S, Ptaszynska A.

Lancet Diabetes Endocrinol. 2016 Mar;4(3):211-20. doi: 10.1016/S2213-8587(15)00417-9. Erratum in: Lancet Diabetes Endocrinol. 2016 Mar;4(3):e3.

PMID: 26620248

 

Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy.

Li YW, Seager MA, Wojcik T, Heman K, Molski TF, Fernandes A, Langdon S, Pendri A, Gerritz S, Tian Y, Hong Y, Gallagher L, Merritt JR, Zhang C, Westphal R, Zaczek R, Macor JE, Bronson JJ, Lodge NJ.

Neuropharmacology. 2016 Mar;102:121-35. doi: 10.1016/j.neuropharm.2015.10.037.

PMID: 26522433

 

HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach.

Lebrec H, Brennan FR, Haggerty H, Herzyk D, Kamperschroer C, Maier CC, Ponce R, Preston BD, Weinstock D, Mellon RD.

Regul Toxicol Pharmacol. 2016 Mar;75:72-80. doi: 10.1016/j.yrtph.2015.12.018.

PMID: 26743742

 

Birth Control in Clinical Trials: Industry Survey of Current Use Practices, Governance, and Monitoring.

Stewart J, Breslin WJ, Beyer BK, Chadwick K, De Schaepdrijver L, Desai M, Enright B, Foster W, Hui JY, Moffat GJ, Tornesi B, Van Malderen K, Wiesner L, Chen CL.

Ther Innov Regul Sci. 2016 Mar;50(2):155-168.

PMID: 27042398

 

 Evaluation of the Relative Performance of Drug-Induced Skeletal Muscle Injury Biomarkers in Rats.

Burch PM, Greg Hall D, Walker EG, Bracken W, Giovanelli R, Goldstein R, Higgs RE, King NM, Lane P, Sauer JM, Michna L, Muniappa N, Pritt ML, Vlasakova K, Watson DE, Wescott D, Zabka TS, Glaab WE.

Toxicol Sci. 2016 Mar;150(1):247-56. doi: 10.1093/toxsci/kfv328.

PMID: 26721300

 

Practical Ni-Catalyzed Aryl-Alkyl Cross-Coupling of Secondary Redox-Active Esters.

Cornella J, Edwards JT, Qin T, Kawamura S, Wang J, Pan CM, Gianatassio R, Schmidt M, Eastgate MD, Baran PS.

J Am Chem Soc. 2016 Feb 24;138(7):2174-7. doi: 10.1021/jacs.6b00250.

PMID: 26835704

 

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease.

Shettigar V, Zhang B, Little SC, Salhi HE, Hansen BJ, Li N, Zhang J, Roof SR, Ho HT, Brunello L, Lerch JK, Weisleder N, Fedorov VV, Accornero F, Rafael-Fortney JA, Gyorke S, Janssen PM, Biesiadecki BJ, Ziolo MT, Davis JP.

Nat Commun. 2016 Feb 24;7:10794. doi: 10.1038/ncomms10794.

PMID: 26908229

 

 Optimization of microchip-based electrophoresis for monoclonal antibody product quality analysis revealed needs for extra surfactants during denaturation.

Cai H, Song Y, Zhang J, Shi T, Fu Y, Li R, Mussa N, Li ZJ.

J Pharm Biomed Anal. 2016 Feb 20;120:46-56. doi: 10.1016/j.jpba.2015.10.041.

PMID: 26704629

 

Regioselective Synthesis of Substituted 4-Alkylamino and 4-Arylaminophthalazin-1(2H)-ones.

Krishnananthan S, Smith D, Wu DR, Yip S, Gunaga P, Mathur A, Li J.

J Org Chem. 2016 Feb 19;81(4):1520-6. doi: 10.1021/acs.joc.5b02652.

PMID:26795884

 

Incidence of venous thromboembolism in France: a retrospective analysis of a national insurance claims database.

Bouée S, Emery C, Samson A, Gourmelen J, Bailly C, Cotté FE.

Thromb J. 2016 Feb 19;14:4. doi: 10.1186/s12959-016-0078-0.

PMID: 26900350

 

Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry.

Yan Y, Wei H, Fu Y, Jusuf S, Zeng M, Ludwig R, Krystek SR Jr, Chen G, Tao L, Das TK.

Anal Chem. 2016 Feb 16;88(4):2041-50. doi: 10.1021/acs.analchem.5b02800.

PMID: 26824491

 

Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines.

Civiello RL, Han X, Beno BR, Chaturvedula PV, Herbst JJ, Xu C, Conway CM, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1229-32. doi: 10.1016/j.bmcl.2016.01.026.

PMID: 26832218

 

Decreased use of glucocorticoids in biological-experienced patients with rheumatoid arthritis who initiated intravenous abatacept: results from the 2-year ACTION study.

Alten R, Nüßlein H, Galeazzi M, Lorenz HM, Nurmohamed MT, Bensen WG, Burmester GR, Peter HH, Pavelka K, Chartier M, Poncet C, Rauch C, Elbez Y, Le Bars M.

RMD Open. 2016 Feb 15;2(1):e000228. doi: 10.1136/rmdopen-2015-000228.

PMID: 26925253

 

Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.

Luo G, Chen L, Burton CR, Xiao H, Sivaprakasam P, Krause CM, Cao Y, Liu N, Lippy J, Clarke WJ, Snow K, Raybon J, Arora V, Pokross M, Kish K, Lewis HA, Langley DR, Macor JE, Dubowchik GM.

J Med Chem. 2016 Feb 11;59(3):1041-51. doi: 10.1021/acs.jmedchem.5b01550.

PMID: 26751161

 

From analytical methods to large scale chiral supercritical fluid chromatography using chlorinated chiral stationary phases.

Wu DR, Yip SH, Li P, Sun D, Mathur A.

J Chromatogr A. 2016 Feb 5;1432:122-31. doi: 10.1016/j.chroma.2015.12.072.

PMID: 26768405

 

A highly sensitive and selective LC-MS/MS method to quantify asunaprevir, an HCV NS3 protease inhibitor, in human plasma in support of pharmacokinetic studies.

Kandoussi H, Jiang H, Zeng J, Zheng N, Kadiyala P, Eley T, He B, Garimella T, Demers R, Cojocaru L, Aubry AF, Arnold ME.

J Pharm Biomed Anal. 2016 Feb 5;119:145-51. doi: 10.1016/j.jpba.2015.11.028.

PMID: 26683987

 

Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity.

Landge S, Ramachandran V, Kumar A, Neres J, Murugan K, Sadler C, Fellows MD, Humnabadkar V, Vachaspati P, Raichurkar A, Sharma S, Ravishankar S, Guptha S, Sambandamurthy VK, Balganesh TS, Ugarkar BG, Balasubramanian V, Bandodkar BS, Panda M.

ChemMedChem. 2016 Feb 4;11(3):331-9. doi: 10.1002/cmdc.201500462.

PMID: 26751718

 

Immunogenicity to Biotherapeutics - The Role of Anti-drug Immune Complexes.

Krishna M, Nadler SG.

Front Immunol. 2016 Feb 2;7:21. doi: 10.3389/fimmu.2016.00021. Review.

PMID: 26870037

 

 Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor.

Sack JS, Gao M, Kiefer SE, Myers JE Jr, Newitt JA, Wu S, Yan C.

Acta Crystallogr F Struct Biol Commun. 2016 Feb;72(Pt 2):129-34. doi: 10.1107/S2053230X15024747.

PMID: 26841763

 

Usability and Acceptability of the Abatacept Pre-Filled Autoinjector for the Subcutaneous Treatment of Rheumatoid Arthritis.

Schiff M, Koo J, Jin E, Schiller E, Day A, Stevens R, Laskar C.

Adv Ther. 2016 Feb;33(2):199-213. doi: 10.1007/s12325-016-0286-9.

PMID: 26833303

 

Supporting open access to clinical trial data for researchers: The Duke Clinical Research Institute-Bristol-Myers Squibb Supporting Open Access to Researchers Initiative.

Pencina MJ, Louzao DM, McCourt BJ, Adams MR, Tayyabkhan RH, Ronco P, Peterson ED.

Am Heart J. 2016 Feb;172:64-9. doi: 10.1016/j.ahj.2015.11.002. Review.

PMID: 26856217

 

Surgical Resection Preferences and Perceptions among Medical Oncologists Treating Liver Metastases from Colorectal Cancer.

Choti MA, Thomas M, Wong SL, Eaddy M, Pawlik TM, Hirose K, Weiss MJ, Kish J, Green MR.

Ann Surg Oncol. 2016 Feb;23(2):375-81. doi: 10.1245/s10434-015-4925-1.

PMID: 26561404

 

Boston Society's 11th Annual Applied Pharmaceutical Analysis conference.

Lee V, Liu A, Groeber E, Moghaddam M, Schiller J, Tweed JA, Walker GS.

Bioanalysis. 2016 Feb;8(4):259-64. doi: 10.4155/bio.15.250.

PMID: 26853375

 

Absolute quantification of imipramine and its metabolites in vivo utilizing calibrators from radiolabeled in vitro incubations.

Bhutani P, Shah D, Varkhede N, Mandlekar S, Chacko S, Subramanian M.

Bioanalysis. 2016 Feb;8(4):297-309. doi: 10.4155/bio.15.259.

PMID: 26847656

 

LC-MS/MS multiplexed assay for the quantitation of a therapeutic protein BMS-986089 and the target protein Myostatin.

Zhu Y, D'Arienzo C, Lou Z, Kozhich A, Madireddi M, Chimalakonda A, Tymiak A, Olah TV.

Bioanalysis. 2016 Feb;8(3):193-204. doi: 10.4155/bio.15.238.

PMID: 26811930

 

Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.

Discenza LN, Cornelius G, Gan J, Szapiel N, Talbott RL, Chaudhry C, Roy A, Borzilleri RM, Vuppugalla R, Stefanski K, Moore R, D'Arienzo CJ, Olah TV, Mehl JT.

Bioanalysis. 2016 Feb;8(4):265-74. doi: 10.4155/bio.15.246.

PMID: 26807991

 

Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.

Hewawasam P, Tu Y, Gao M, Hanumegowda U, Knipe J, Lemm JA, Parker DD, Rigat KL, Roberts SB, Meanwell NA, Kadow JF.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):936-40. doi: 10.1016/j.bmcl.2015.12.058.

PMID: 26747393

 

A Developmental Toxicology Assay Platform for Screening Teratogenic Liability of Pharmaceutical Compounds.

Augustine-Rauch K, Zhang CX, Panzica-Kelly JM.

Birth Defects Res B Dev Reprod Toxicol. 2016 Feb;107(1):4-20. doi: 10.1002/bdrb.21168.

PMID: 26729651

 

Predicting analysis times in randomized clinical trials with cancer immunotherapy.

Chen TT.

BMC Med Res Methodol. 2016 Feb 1;16:12. doi: 10.1186/s12874-016-0117-3.

PMID: 26830911

 

 Daclatasvir and Sofosbuvir Versus Sofosbuvir and Ribavirin in Patients with Chronic Hepatitis C Coinfected with HIV: A Matching-adjusted Indirect Comparison.

Swallow E, Song J, Yuan Y, Kalsekar A, Kelley C, Peeples M, Mu F, Ackerman P, Signorovitch J.

Clin Ther. 2016 Feb;38(2):404-12. doi: 10.1016/j.clinthera.2015.12.017. Review.

PMID: 26839044

 

Pharmacokinetics of Weekly Paclitaxel and Feasibility of Dexamethasone Taper in Japanese Patients with Advanced Non-small Cell Lung Cancer.

Nokihara H, Yamamoto N, Ohe Y, Hiraoka M, Tamura T.

Clin Ther. 2016 Feb;38(2):338-47. doi: 10.1016/j.clinthera.2015.12.009.

PMID: 26774841

 

Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.

Shen H, Liu T, Jiang H, Titsch C, Taylor K, Kandoussi H, Qiu X, Chen C, Sukrutharaj S, Kuit K, Mintier G, Krishnamurthy P, Fancher RM, Zeng J, Rodrigues AD, Marathe P, Lai Y.

Drug Metab Dispos. 2016 Feb;44(2):238-49. doi: 10.1124/dmd.115.066852.

PMID: 26608080

 

The cost-effectiveness of daclatasvir-based regimens for the treatment of hepatitis C virus genotypes 1 and 4 in the UK.

McEwan P, Bennett H, Ward T, Webster S, Gordon J, Kalsekar A, Yuan Y, Brenner M.

Eur J Gastroenterol Hepatol. 2016 Feb;28(2):173-80. doi: 10.1097/MEG.0000000000000510.

PMID: 26545086

 

A phase I trial of pegylated liposomal doxorubicin (PLD), carboplatin, bevacizumab and veliparib in recurrent, platinum-sensitive ovarian, primary peritoneal, and fallopian tube cancer: An NRG Oncology/Gynecologic Oncology Group study.

Landrum LM, Brady WE, Armstrong DK, Moore KN, DiSilvestro PA, O'Malley DM, Tenney ME, Rose PG, Fracasso PM.

Gynecol Oncol. 2016 Feb;140(2):204-9. doi: 10.1016/j.ygyno.2015.11.024.

PMID: 26616225

 

Randomized, controlled trial of entecavir versus placebo in children with hepatitis B envelope antigen-positive chronic hepatitis B.

Jonas MM, Chang MH, Sokal E, Schwarz KB, Kelly D, Kim KM, Ling SC, Rosenthal P, Oraseanu D, Reynolds L, Thiry A, Ackerman P.

Hepatology. 2016 Feb;63(2):377-87. doi: 10.1002/hep.28015.

PMID: 26223345

 

Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening.

Haarhoff Z, Wagner A, Picard P, Drexler DM, Zvyaga T, Shou W.

J Biomol Screen. 2016 Feb;21(2):165-75. doi: 10.1177/1087057115607184.

PMID: 26420787

 

Treatment Outcomes With First-line Therapies With Entecavir and Tenofovir in Treatment-Naive Chronic Hepatitis B Patients in a Routine Clinical Practice.

Ha NB, Trinh HN, Rosenblatt L, Nghiem D, Nguyen MH.

J Clin Gastroenterol. 2016 Feb;50(2):169-74. doi: 10.1097/MCG.0000000000000345.

PMID: 26018133

 

Immune Checkpoint inhibitors: An introduction to the next-generation cancer immunotherapy.

Lee L, Gupta M, Sahasranaman S.

J Clin Pharmacol. 2016 Feb;56(2):157-69. doi: 10.1002/jcph.591. Review.

PMID: 26183909

 

Best practices for the use of itraconazole as a replacement for ketoconazole in drug-drug interaction studies.

Liu L, Bello A, Dresser MJ, Heald D, Komjathy SF, O'Mara E, Rogge M, Stoch SA, Robertson SM.

J Clin Pharmacol. 2016 Feb;56(2):143-51. doi: 10.1002/jcph.562. Review.

PMID: 26044116

 

Daclatasvir plus simeprevir with or without ribavirin for the treatment of chronic hepatitis C virus genotype 1 infection.

Zeuzem S, Hézode C, Bronowicki JP, Loustaud-Ratti V, Gea F, Buti M, Olveira A, Banyai T, Al-Assi MT, Petersen J, Thabut D, Gadano A, Pruitt R, Makara M, Bourlière M, Pol S, Beumont-Mauviel M, Ouwerkerk-Mahadevan S, Picchio G, Bifano M, McPhee F, Boparai N, Cheung K, Hughes EA, Noviello S; LEAGUE-1 Study Team..

J Hepatol. 2016 Feb;64(2):292-300. doi: 10.1016/j.jhep.2015.09.024.

PMID: 26453968

 

Acoustic Sample Deposition MALDI-MS (ASD-MALDI-MS): A Novel Process Flow for Quality Control Screening of Compound Libraries.

Chin J, Wood E, Peters GS, Drexler DM.

J Lab Autom. 2016 Feb;21(1):204-7. doi: 10.1177/2211068215594769.

PMID: 26203056

 

Utility of PBPK Absorption Modeling to Guide Modified Release Formulation Development of Gaboxadol, a Highly Soluble Compound With Region-Dependent Absorption.

Kesisoglou F, Balakrishnan A, Manser K.

J Pharm Sci. 2016 Feb;105(2):722-8. doi: 10.1002/jps.24674.

PMID: 26457884

 

Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.

Alt A, Pendri A, Bertekap RL Jr, Li G, Benitex Y, Nophsker M, Rockwell KL, Burford NT, Sum CS, Chen J, Herbst JJ, Ferrante M, Hendricson A, Cvijic ME, Westphal RS, O'Connell J, Banks M, Zhang L, Gentles RG, Jenkins S, Loy J, Macor JE.

J Pharmacol Exp Ther. 2016 Feb;356(2):293-304. doi: 10.1124/jpet.115.226910.

PMID: 26582730

 

Safety and Efficacy of Open-label Subcutaneous Ixekizumab Treatment for 48 Weeks in a Phase II Study in Biologic-naive and TNF-IR Patients with Rheumatoid Arthritis.

Genovese MC, Braun DK, Erickson JS, Berclaz PY, Banerjee S, Heffernan MP, Carlier H.

J Rheumatol. 2016 Feb;43(2):289-97. doi: 10.3899/jrheum.140831.

PMID: 26669919

 

Daclatasvir + asunaprevir + beclabuvir ± ribavirin for chronic HCV genotype 1-infected treatment-naive patients.

Everson GT, Sims KD, Thuluvath PJ, Lawitz E, Hassanein T, Rodriguez-Torres M, Desta T, Hawkins T, Levin JM, Hinestrosa F, Rustgi V, Schwartz H, Younossi Z, Webster L, Gitlin N, Eley T, Huang SP, McPhee F, Grasela DM, Gardiner DF.

Liver Int. 2016 Feb;36(2):189-97. doi: 10.1111/liv.12964.

PMID: 26473667

 

STP Best Practices for Evaluating Clinical Pathology in Pharmaceutical Recovery Studies.

Tomlinson L, Ramaiah L, Tripathi NK, Barlow VG, Vitsky A, Poitout-Belissent FM, Bounous DI, Ennulat D.

Toxicol Pathol. 2016 Feb;44(2):163-72. doi: 10.1177/0192623315624165.

PMID: 26879687

 

Belatacept and Long-Term Outcomes in Kidney Transplantation.

Vincenti F, Rostaing L, Grinyo J, Rice K, Steinberg S, Gaite L, Moal MC, Mondragon-Ramirez GA, Kothari J, Polinsky MS, Meier-Kriesche HU, Munier S, Larsen CP.

N Engl J Med. 2016 Jan 28;374(4):333-43. doi: 10.1056/NEJMoa1506027. Erratum in: N Engl J Med. 2016 Feb 18;374(7):698.

PMID: 26816011

 

Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate.

Villaume MT, Sella E, Saul G, Borzilleri RM, Fargnoli J, Johnston KA, Zhang H, Fereshteh MP, Dhar TG, Baran PS.

ACS Cent Sci. 2016 Jan 27;2(1):27-31. doi: 10.1021/acscentsci.5b00345.

PMID: 27163023

 

Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.

Ehrhardt A, Chung WJ, Pyle LC, Wang W, Nowotarski K, Mulvihill CM, Ramjeesingh M, Hong J, Velu SE, Lewis HA, Atwell S, Aller S, Bear CE, Lukacs GL, Kirk KL, Sorscher EJ.

J Biol Chem. 2016 Jan 22;291(4):1854-65. doi: 10.1074/jbc.M115.704809.

PMID: 26627831

 

Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.

Dhar TG, Xiao HY, Xie J, Lehman-McKeeman LD, Wu DR, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Warrack B, Shi H, Levesque PC, Zhu JL, Hennan J, Balimane P, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ.

ACS Med Chem Lett. 2016 Jan 19;7(3):283-8. doi: 10.1021/acsmedchemlett.5b00448.

PMID: 26985316

 

Label-Free Bottom-Up Proteomic Workflow for Simultaneously Assessing the Target Specificity of Covalent Drug Candidates and Their Off-Target Reactivity to Selected Proteins.

Yang Y, Shu YZ, Humphreys WG.

Chem Res Toxicol. 2016 Jan 19;29(1):109-16. doi: 10.1021/acs.chemrestox.5b00460.

PMID: 26675335

 

Novel technologies and emerging biomarkers for personalized cancer immunotherapy.

Yuan J, Hegde PS, Clynes R, Foukas PG, Harari A, Kleen TO, Kvistborg P, Maccalli C, Maecker HT, Page DB, Robins H, Song W, Stack EC, Wang E, Whiteside TL, Zhao Y, Zwierzina H, Butterfield LH, Fox BA.

J Immunother Cancer. 2016 Jan 19;4:3. doi: 10.1186/s40425-016-0107-3. Review.

PMID: 26788324

 

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway.

Kashyap MK, Kumar D, Jones H, Amaya-Chanaga CI, Choi MY, Melo-Cardenas J, Ale-Ali A, Kuhne MR, Sabbatini P, Cohen LJ, Shelat SG, Rassenti LZ, Kipps TJ, Cardarelli PM, Castro JE.

Oncotarget. 2016 Jan 19;7(3):2809-22. doi: 10.18632/oncotarget.6465.

PMID: 26646452

 

Novel phenylalanine derived diamides as Factor XIa inhibitors.

Smith LM 2nd, Orwat MJ, Hu Z, Han W, Wang C, Rossi KA, Gilligan PJ, Pabbisetty KB, Osuna H, Corte JR, Rendina AR, Luettgen JM, Wong PC, Narayanan R, Harper TW, Bozarth JM, Crain EJ, Wei A, Ramamurthy V, Morin PE, Xin B, Zheng J, Seiffert DA, Quan ML, Lam PY, Wexler RR, Pinto DJ.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):472-8. doi: 10.1016/j.bmcl.2015.11.089.

PMID: 26704266

 

Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity.

Brown GD, Shi Q, Delucca GV, Batt DG, Galella MA, Cvijic ME, Liu RQ, Qiu F, Zhao Q, Barrish JC, Carter PH.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):662-6. doi: 10.1016/j.bmcl.2015.11.051.

PMID: 26631321

 

NS5A Sequence Heterogeneity and Mechanisms of Daclatasvir Resistance in Hepatitis C Virus Genotype 4 Infection.

Zhou N, Hernandez D, Ueland J, Yang X, Yu F, Sims K, Yin PD, McPhee F.

J Infect Dis. 2016 Jan 15;213(2):206-15. doi: 10.1093/infdis/jiv379.

PMID: 26170396

 

Bioequivalence of saxagliptin/dapagliflozin fixed-dose combination tablets compared with coadministration of the individual tablets to healthy subjects.

Vakkalagadda B, Vetter ML, Rana J, Smith CH, Huang J, Karkas J, Boulton DW, LaCreta F.

Pharmacol Res Perspect. 2016 Jan 12;3(6):e00201. doi: 10.1002/prp2.201.

PMID: 27022473

 

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.

Wu YJ, Guernon J, Yang F, Snyder L, Shi J, Mcclure A, Rajamani R, Park H, Ng A, Lewis H, Chang C, Camac D, Toyn JH, Ahlijanian MK, Albright CF, Macor JE, Thompson LA.

ACS Med Chem Lett. 2016 Jan 11;7(3):271-6. doi: 10.1021/acsmedchemlett.5b00432.

PMID: 26985314

 

Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.

He J, Jiang H, Takise R, Zhu RY, Chen G, Dai HX, Dhar TG, Shi J, Zhang H, Cheng PT, Yu JQ.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):785-9. doi: 10.1002/anie.201509996.

PMID: 26611496

 

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC.

PLoS Pathog. 2016 Jan 7;12(1):e1005349. doi: 10.1371/journal.ppat.1005349.

PMID: 26741490

 

 Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5.

Yang F, Snyder LB, Balakrishnan A, Brown JM, Sivarao DV, Easton A, Fernandes A, Gulianello M, Hanumegowda UM, Huang H, Huang Y, Jones KM, Li YW, Matchett M, Mattson G, Miller R, Santone KS, Senapati A, Shields EE, Simutis FJ, Westphal R, Whiterock VJ, Bronson JJ, Macor JE, Degnan AP.

ACS Med Chem Lett. 2016 Jan 4;7(3):289-93. doi: 10.1021/acsmedchemlett.5b00450.

PMID: 26985317

 

Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type.

Jackson MJ, Kestur US, Hussain MA, Taylor LS.

Mol Pharm. 2016 Jan 4;13(1):223-31. doi: 10.1021/acs.molpharmaceut.5b00652.

PMID: 26618718

 

Recommendations for Use and Fit-for-Purpose Validation of Biomarker Multiplex Ligand Binding Assays in Drug Development.

Jani D, Allinson J, Berisha F, Cowan KJ, Devanarayan V, Gleason C, Jeromin A, Keller S, Khan MU, Nowatzke B, Rhyne P, Stephen L.

AAPS J. 2016 Jan;18(1):1-14. doi: 10.1208/s12248-015-9820-y. Review.

PMID: 26377333

 

Warfarin Discontinuation in Patients With Unprovoked Venous Thromboembolism: A Large US Insurance Database Analysis.

Xie L, Liu X, Phatak H, Mardekian J, Tan W, Baser O, Ramacciotti E.

Am J Ther. 2016 Nov/Dec;23(6):e1744-e1753.

PMID: 26214203

 

Overview on biotherapeutic proteins: impact on bioanalysis.

Zhang YJ, Luo L, Desai DD.

Bioanalysis. 2016;8(1):1-9. doi: 10.4155/bio.15.224. Review.

PMID: 26648322

 

Determination of kynurenic acid in rat cerebrospinal fluid by HPLC with fluorescence detection.

Bao Y, Luchetti D, Schaeffer E, Cutrone J.

Biomed Chromatogr. 2016 Jan;30(1):62-7. doi: 10.1002/bmc.3492.

PMID: 25963282

 

Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.

Swidorski JJ, Liu Z, Yin Z, Wang T, Carini DJ, Rahematpura S, Zheng M, Johnson K, Zhang S, Lin PF, Parker DD, Li W, Meanwell NA, Hamann LG, Regueiro-Ren A.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):160-7. doi: 10.1016/j.bmcl.2015.11.009.

PMID: 26584882

 

The use of 'Omics technology to rationally improve industrial mammalian cell line performance.

Lewis AM, Abu-Absi NR, Borys MC, Li ZJ.

Biotechnol Bioeng. 2016 Jan;113(1):26-38. doi: 10.1002/bit.25673. Review.

PMID: 26059229

 

Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade.

Weber MA, Mansfield TA, Alessi F, Iqbal N, Parikh S, Ptaszynska A.

Blood Press. 2016;25(2):93-103. doi: 10.3109/08037051.2015.1116258.

PMID: 26623980

 

First-in-human multicenter phase I study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70.

Owonikoko TK, Hussain A, Stadler WM, Smith DC, Kluger H, Molina AM, Gulati P, Shah A, Ahlers CM, Cardarelli PM, Cohen LJ.

Cancer Chemother Pharmacol. 2016 Jan;77(1):155-62. doi: 10.1007/s00280-015-2909-2.

PMID: 26576779

 

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells.

Sánchez-Paulete AR, Cueto FJ, Martínez-López M, Labiano S, Morales-Kastresana A, Rodríguez-Ruiz ME, Jure-Kunkel M, Azpilikueta A, Aznar MA, Quetglas JI, Sancho D, Melero I.

Cancer Discov. 2016 Jan;6(1):71-9. doi: 10.1158/2159-8290.CD-15-0510.

PMID: 26493961

 

Real-World Medical Cost Avoidance When New Oral Anticoagulants are Used Versus Warfarin for Venous Thromboembolism in the United States.

Amin A, Bruno A, Trocio J, Lin J, Lingohr-Smith M.

Clin Appl Thromb Hemost. 2016 Jan;22(1):5-11. doi: 10.1177/1076029615585991. Review.

PMID: 25993994

 

Safety, pharmacokinetics, and pharmacodynamics of PD 0348292, an oral, direct factor Xa inhibitor, after single and multiple dosings in healthy subjects.

Xuan D, McBride S, Wastall P, Porcari A, DiCarlo L, Boyd RA.

Clin Pharmacol Drug Dev. 2016 Jan;5(1):13-26. doi: 10.1002/cpdd.232.

PMID: 27119575

 

Fed and Fasted Single-dose Assessment of Bioequivalence of Dapagliflozin and Metformin Extended-release Fixed-dose Combination Tablets Relative to Single-component Dapagliflozin and Metformin Extended-release Tablets in Healthy Subjects.

Boulton DW, Chang M, Griffen SC, Kitaura C, Lubin S, Pollack A, LaCreta F.

Clin Ther. 2016 Jan 1;38(1):99-109. doi: 10.1016/j.clinthera.2015.11.010.

PMID: 26682500

 

An early evaluation of bleeding-related hospital readmissions among hospitalized patients with nonvalvular atrial fibrillation treated with direct oral anticoagulants.

Deitelzweig S, Bruno A, Trocio J, Tate N, Gupta K, Lin J, Lingohr-Smith M.

Curr Med Res Opin. 2016;32(3):573-82. doi: 10.1185/03007995.2015.1131676.

PMID: 26652179

 

Methods applied in cost-effectiveness models for treatment strategies in type 2 diabetes mellitus and their use in Health Technology Assessments: a systematic review of the literature from 2008 to 2013.

Charokopou M, Sabater FJ, Townsend R, Roudaut M, McEwan P, Verheggen BG.

Curr Med Res Opin. 2016;32(2):207-18. doi: 10.1185/03007995.2015.1102722. Review.

PMID: 26473650

 

Warfarin time in therapeutic range and its impact on healthcare resource utilization and costs among patients with nonvalvular atrial fibrillation.

Deitelzweig S, Evans M, Hillson E, Trocio J, Bruno A, Tan W, Lingohr-Smith M, Singh P, Lin J.

Curr Med Res Opin. 2016;32(1):87-94. doi: 10.1185/03007995.2015.1103217.

PMID: 26451675

 

A quality by design approach to scale-up of high-shear wet granulation process.

Pandey P, Badawy S.

Drug Dev Ind Pharm. 2016;42(2):175-89. doi: 10.3109/03639045.2015.1100199. Review.

PMID: 26489403

 

Assessing impact of manufacturing and package configurations to photosensitive compounds.

Carvalho TC, Escotet ML, Lin J, Sprockel OL.

Drug Dev Ind Pharm. 2016;42(6):936-44. doi: 10.3109/03639045.2015.1091472.

PMID: 26460067

 

Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.

Roberts DJ, McKeon M, Xu Y, Stankowski LF Jr.

Environ Mol Mutagen. 2016 Jan;57(1):17-27. doi: 10.1002/em.21981.

PMID: 26407646

 

A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference.

Kirchhof P, Breithardt G, Bax J, Benninger G, Blomstrom-Lundqvist C, Boriani G, Brandes A, Brown H, Brueckmann M, Calkins H, Calvert M, Christoffels V, Crijns H, Dobrev D, Ellinor P, Fabritz L, Fetsch T, Freedman SB, Gerth A, Goette A, Guasch E, Hack G, Haegeli L, Hatem S, Haeusler KG, Heidbüchel H, Heinrich-Nols J, Hidden-Lucet F, Hindricks G, Juul-Möller S, Kääb S, Kappenberger L, Kespohl S, Kotecha D, Lane DA, Leute A, Lewalter T, Meyer R, Mont L, Münzel F, Nabauer M, Nielsen JC, Oeff M, Oldgren J, Oto A, Piccini JP, Pilmeyer A, Potpara T, Ravens U, Reinecke H, Rostock T, Rustige J, Savelieva I, Schnabel R, Schotten U, Schwichtenberg L, Sinner MF, Steinbeck G, Stoll M, Tavazzi L, Themistoclakis S, Tse HF, Van Gelder IC, Vardas PE, Varpula T, Vincent A, Werring D, Willems S, Ziegler A, Lip GY, Camm AJ.

Europace. 2016 Jan;18(1):37-50. doi: 10.1093/europace/euv304. Review.

PMID: 26481149

 

Hepatic drug transporters: the journey so far.

Riley RJ, Foley SA, Barton P, Soars MG, Williamson B.

Expert Opin Drug Metab Toxicol. 2016;12(2):201-16. doi: 10.1517/17425255.2016.1132308. Review.

PMID: 26670591

 

Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes.

Diao X, Scheidweiler KB, Wohlfarth A, Zhu M, Pang S, Huestis MA.

Forensic Toxicol. 2016;34:256-267.

PMID: 27547265

 

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.

Fermini B, Hancox JC, Abi-Gerges N, Bridgland-Taylor M, Chaudhary KW, Colatsky T, Correll K, Crumb W, Damiano B, Erdemli G, Gintant G, Imredy J, Koerner J, Kramer J, Levesque P, Li Z, Lindqvist A, Obejero-Paz CA, Rampe D, Sawada K, Strauss DG, Vandenberg JI.

J Biomol Screen. 2016 Jan;21(1):1-11. doi: 10.1177/1087057115594589. Review.

PMID: 26170255

 

Testing for parallelism in the heteroscedastic four-parameter logistic model.

Sidik K, Jonkman JN.

J Biopharm Stat. 2016;26(2):250-68. doi: 10.1080/10543406.2014.1003432.

PMID: 25629201

 

Management of epidermal growth factor receptor inhibitor-associated rash: a systematic review.

Brown J, Su Y, Nelleson D, Shankar P, Mayo C.

J Community Support Oncol. 2016 Jan;14(1):21-8. doi: 10.12788/jcso.0193.

PMID: 26870839

 

Randomized comparison of daclatasvir + asunaprevir versus telaprevir + peginterferon/ribavirin in Japanese hepatitis C virus patients.

Kumada H, Suzuki F, Suzuki Y, Toyota J, Karino Y, Chayama K, Kawakami Y, Fujiyama S, Ito T, Itoh Y, Tamura E, Ueki T, Ishikawa H, Hu W, McPhee F, Linaberry M, Hughes E.

J Gastroenterol Hepatol. 2016 Jan;31(1):14-22. doi: 10.1111/jgh.13073.

PMID: 26252875

 

Persistence, adherence, and all-cause healthcare costs in atazanavir- and darunavir-treated patients with human immunodeficiency virus in a real-world setting.

Farr AM, Johnston SS, Ritchings C, Brouillette M, Rosenblatt L.

J Med Econ. 2016;19(4):386-96. doi: 10.3111/13696998.2015.1128942.

PMID: 26640980

 

Cost-effectiveness analysis of second-line tyrosine kinase inhibitor treatment for chronic myelogenous leukemia.

Whalen J, Stillman I, Ambavane A, Felber E, Makenbaeva D, Bolinder B.

J Med Econ. 2016;19(5):445-61. doi: 10.3111/13696998.2015.1126285.

PMID: 26613118

 

A retrospective study of persistence, adherence, and health economic outcomes of fixed-dose combination vs. loose-dose combination of oral anti-diabetes drugs.

Lokhandwala T, Smith N, Sternhufvud C, Sörstadius E, Lee WC, Mukherjee J.

J Med Econ. 2016;19(3):203-12. doi: 10.3111/13696998.2015.1109518.

PMID: 26473990

 

Process Analytical Technology for High Shear Wet Granulation: Wet Mass Consistency Reported by In-Line Drag Flow Force Sensor Is Consistent With Powder Rheology Measured by At-Line FT4 Powder Rheometer.

Narang AS, Sheverev V, Freeman T, Both D, Stepaniuk V, Delancy M, Millington-Smith D, Macias K, Subramanian G.

J Pharm Sci. 2016 Jan;105(1):182-7. doi: 10.1016/j.xphs.2015.11.030.

PMID: 26852853

 

Integrated Application of Quality-by-Design Principles to Drug Product Development: A Case Study of Brivanib Alaninate Film-Coated Tablets.

Badawy SI, Narang AS, LaMarche KR, Subramanian GA, Varia SA, Lin J, Stevens T, Shah PA.

J Pharm Sci. 2016 Jan;105(1):168-81. doi: 10.1016/j.xphs.2015.11.023.

PMID: 26852852

 

Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly blinded trial.

Gupta SK, McComsey GA, Lombaard J, Echevarría J, Orrell C, Avihingsanon A, Osiyemi O, Santoscoy M, Ray N, Stock DA, Joshi SR, Hanna GJ, Lataillade M.

Lancet HIV. 2016 Jan;3(1):e13-22. doi: 10.1016/S2352-3018(15)00231-3.

PMID: 26762988

 

Lymphoma in acquired generalized lipodystrophy.

Brown RJ, Chan JL, Jaffe ES, Cochran E, DePaoli AM, Gautier JF, Goujard C, Vigouroux C, Gorden P.

Leuk Lymphoma. 2016;57(1):45-50. doi: 10.3109/10428194.2015.1040015.

PMID: 25864863

 

Multi-Site N-glycan mapping study 1: Capillary electrophoresis - laser induced fluorescence.

Szekrényes Á, Park SS, Santos M, Lew C, Jones A, Haxo T, Kimzey M, Pourkaveh S, Szabó Z, Sosic Z, Feng P, Váradi C, de l'Escaille F, Falmagne JB, Sejwal P, Niedringhaus T, Michels D, Freckleton G, Hamm M, Manuilov A, Schwartz M, Luo JK, van Dyck J, Leung PK, Olajos M, Gu Y, Gao K, Wang W, Wegstein J, Tep S, Guttman A.

MAbs. 2016;8(1):56-64. doi: 10.1080/19420862.2015.1107687.

PMID: 26466659

 

No Evidence of an Association Between Efavirenz Exposure and Suicidality Among HIV Patients Initiating Antiretroviral Therapy in a Retrospective Cohort Study of Real World Data.

Nkhoma ET, Coumbis J, Farr AM, Johnston SS, Chu BC, Rosenblatt LC, Seekins D, Villasis-Keever A.

Medicine (Baltimore). 2016 Jan;95(3):e2480. doi: 10.1097/MD.0000000000002480.

PMID: 26817882

 

Purification and Functional Reconstitution of Box H/ACA Ribonucleoprotein Particles.

Huang C, Wu G, Yu YT.

Methods Mol Biol. 2016;1421:97-109. doi: 10.1007/978-1-4939-3591-8_9.

PMID: 26965260

 

Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains.

Weed MR, Bookbinder M, Polino J, Keavy D, Cardinal RN, Simmermacher-Mayer J, Cometa FN, King D, Thangathirupathy S, Macor JE, Bristow LJ.

Neuropsychopharmacology. 2016 Jan;41(2):568-77. doi: 10.1038/npp.2015.184.

PMID: 26105137

 

Feasibility of Using Fluorescence Spectrophotometry to Develop a Sensitive Dye Immersion Method for Container Closure Integrity Testing of Prefilled Syringes.

Lu X, Lloyd DK, Klohr SE.

PDA J Pharm Sci Technol. 2016 Jan-Feb;70(1):39-50. doi: 10.5731/pdajpst.2015.006015.

PMID: 26889055

 

Effect of pepsin on maintaining the supersaturation of the HCl salt of a weakly basic drug: a case study.

Pinnamaneni S, Rinaldi FA, Jayawickrama DA, Li J, Dali MV.

Pharm Dev Technol. 2016;21(3):311-20. doi: 10.3109/10837450.2014.1003653.

PMID: 25708152

 

Reprint of "Potential seminal transport of pharmaceuticals to the conceptus".

Scialli AR, Bailey G, Beyer BK, Bøgh IB, Breslin WJ, Chen CL, DeLise AM, Hui JY, Moffat GJ, Stewart J, Thompson KE.

Reprod Toxicol. 2016 Jan;59:22-30. doi: 10.1016/j.reprotox.2016.01.005. Review.

PMID: 26854737

 

Assessment of cervical passage of vital dyes in pregnant, nonpregnant, and mated rats and mice.

Thompson KE, Rayhon SL, Bailey G, Delille P, McNerney ME.

Reprod Toxicol. 2016 Jan;59:1-7. doi: 10.1016/j.reprotox.2015.10.018.

PMID: 26546978

 

Evaluation of early fetal exposure to vaginally-administered metronidazole in pregnant cynomolgus monkeys.

Thompson KE, Newcomb DL, Moffat GJ, Zalikowski J, Chellman GJ, McNerney ME.

Reprod Toxicol. 2016 Jan;59:17-21. doi: 10.1016/j.reprotox.2015.10.013.

PMID: 26524246

 

Cardioprotection by Thymosin Beta 4.

Pipes GT, Yang J.

Vitam Horm. 2016;102:209-26. doi: 10.1016/bs.vh.2016.04.004.

PMID: 27450736

 

Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans.

Gong J, Eley T, He B, Arora V, Philip T, Jiang H, Easter J, Humphreys WG, Iyer RA, Li W.

Xenobiotica. 2016;46(1):52-64. doi: 10.3109/00498254.2015.1048487.

PMID: 26153443

Back to Top

2015 Publications

Measuring the sticking of mefenamic acid powders on stainless steel surface.

Wang Z, Shah UV, Olusanmi D, Narang AS, Hussain MA, Gamble JF, Tobyn MJ, Heng JY.

Int J Pharm. 2015 Dec 30;496(2):407-13. doi: 10.1016/j.ijpharm.2015.09.067.

PMID: 26456293

 

Synergistic Activity of Combined NS5A Inhibitors.

O'Boyle DR 2nd, Nower PT, Gao M, Fridell R, Wang C, Hewawasam P, Lopez O, Tu Y, Meanwell NA, Belema M, Roberts SB, Cockett M, Sun JH.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1573-83. doi: 10.1128/AAC.02639-15.

PMID: 26711745

 

Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry.

Wang C, Chen S, Brailsford JA, Yamniuk AP, Tymiak AA, Zhang Y.

J Chromatogr A. 2015 Dec 24;1426:133-9. doi: 10.1016/j.chroma.2015.11.065.

PMID: 26674608

 

The Predicted Impact of Ipilimumab Usage on Survival in Previously Treated Advanced or Metastatic Melanoma in the UK.

Larkin J, Hatswell AJ, Nathan P, Lebmeier M, Lee D.

PLoS One. 2015 Dec 23;10(12):e0145524. doi: 10.1371/journal.pone.0145524.

PMID: 26700304

 

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains.

Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ.

PLoS Genet. 2015 Dec 22;11(12):e1005711. doi: 10.1371/journal.pgen.1005711. Erratum in: PLoS Genet. 2016 Mar;12(3):e1005913.

PMID: 26694027

 

Asymmetric Synthesis of Heterocyclic Analogues of a CGRP Receptor Antagonist for Treating Migraine.

Luo G, Chen L, Conway CM, Kostich W, Macor JE, Dubowchik GM.

Org Lett. 2015 Dec 18;17(24):5982-5. doi: 10.1021/acs.orglett.5b02921.

PMID: 26650258

 

General Method for the Preparation of Electron-Deficient Imidazo[1,2-a]pyridines and Related Heterocycles.

McDonald IM, Peese KM.

Org Lett. 2015 Dec 18;17(24):6002-5. doi: 10.1021/acs.orglett.5b02966.

PMID: 26598965

 

Post-pellet-digestion precipitation and solid phase extraction: A practical and efficient workflow to extract surrogate peptides for ultra-high performance liquid chromatography--tandem mass spectrometry bioanalysis of a therapeutic antibody in the low ng/mL range.

Gong C, Zheng N, Zeng J, Aubry AF, Arnold ME.

J Chromatogr A. 2015 Dec 11;1424:27-36. doi: 10.1016/j.chroma.2015.10.049.

PMID: 26525666

 

Clinical outcomes in patients with atrial fibrillation according to sex during anticoagulation with apixaban or warfarin: a secondary analysis of a randomized controlled trial.

Vinereanu D, Stevens SR, Alexander JH, Al-Khatib SM, Avezum A, Bahit MC, Granger CB, Lopes RD, Halvorsen S, Hanna M, Husted S, Hylek EM, Mărgulescu AD, Wallentin L, Atar D.

Eur Heart J. 2015 Dec 7;36(46):3268-75. doi: 10.1093/eurheartj/ehv447.

PMID: 26371113

 

Mitigation of Adverse Clinical Events of a Narrow Target Therapeutic Index Compound through Modified Release Formulation Design: An in Vitro, in Vivo, in Silico, and Clinical Pharmacokinetic Analysis.

Good DJ, Hartley R, Mathias N, Crison J, Tirucherai G, Timmins P, Hussain M, Haddadin R, Koo O, Nikfar F, Fung NK.

Mol Pharm. 2015 Dec 7;12(12):4434-44. doi: 10.1021/acs.molpharmaceut.5b00624.

PMID: 26536519

 

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer.

Huang A, Jayaraman L, Fura A, Vite GD, Trainor GL, Gottardis MM, Spires TE, Spires VM, Rizzo CA, Obermeier MT, Elzinga PA, Todderud G, Fan Y, Newitt JA, Beyer SM, Zhu Y, Warrack BM, Goodenough AK, Tebben AJ, Doweyko AM, Gold DL, Balog A.

ACS Med Chem Lett. 2015 Dec 2;7(1):40-5. doi: 10.1021/acsmedchemlett.5b00310.

PMID: 26819663

 

Finite Element Method (FEM) Modeling of Freeze-drying: Monitoring Pharmaceutical Product Robustness During Lyophilization.

Chen X, Sadineni V, Maity M, Quan Y, Enterline M, Mantri RV.

AAPS PharmSciTech. 2015 Dec;16(6):1317-26. doi: 10.1208/s12249-015-0318-9.

PMID: 25791415

 

Anticipated Impact of Generic Imatinib Market Entry on the Costs of Tyrosine Kinase Inhibitors.

Bloudek LM, Makenbaeva D, Eaddy M.

Am Health Drug Benefits. 2015 Dec;8(9):472-80.

PMID: 26834933

 

The impact of dasatinib on pregnancy outcomes.

Cortes JE, Abruzzese E, Chelysheva E, Guha M, Wallis N, Apperley JF.

Am J Hematol. 2015 Dec;90(12):1111-5. doi: 10.1002/ajh.24186.

PMID: 26348106

 

2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 3--LBA, biomarkers and immunogenicity).

Amaravadi L, Song A, Myler H, Thway T, Kirshner S, Devanarayan V, Ni YG, Garofolo F, Birnboeck H, Richards S, Gupta S, Luo L, Kingsley C, Salazar-Fontana L, Fraser S, Gorovits B, Allinson J, Barger T, Chilewski S, Fjording MS, Haidar S, Islam R, Jaitner B, Kamerud J, Katori N, Krinos-Fiorotti C, Lanham D, Ma M, McNally J, Morimoto A, Mytych D, Nogueira da Costa A, Papadimitriou A, Pillutla R, Ray S, Safavi A, Savoie N, Schaefer M, Shih J, Smeraglia J, Skelly MF, Spond J, Staack RF, Stouffer B, Tampal N, Torri A, Welink J, Yang TY, Zoghbi J.

Bioanalysis. 2015 Dec;7(24):3107-24. doi: 10.4155/bio.15.226.

PMID: 26635247

 

2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 2 - hybrid LBA/LCMS and input from regulatory agencies).

Ackermann B, Neubert H, Hughes N, Garofolo F, Abberley L, Alley SC, Brown-Augsburger P, Bustard M, Chen LZ, Heinrich J, Katori N, Kaur S, Kirkovsky L, Laterza OF, Le Blaye O, Lévesque A, Santos GM, Olah T, Savoie N, Skelly M, Spitz S, Szapacs M, Tampal N, Wang J, Welink J, Wieling J, Haidar S, Vinter S, Whale E, Witte B.

Bioanalysis. 2015 Dec;7(23):3019-34. doi: 10.4155/bio.15.214.

PMID: 26627049

 

So you think your assay is robust?

Aubry AF, Weng N.

Bioanalysis. 2015 Dec;7(23):2969-71. doi: 10.4155/bio.15.198. No abstract available.

PMID: 26616477

 

Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.

Datta D, Arion D, Corradi JP, Lewis DA.

Biol Psychiatry. 2015 Dec 1;78(11):775-85. doi: 10.1016/j.biopsych.2015.03.030.

PMID: 25981171

 

Statistical Challenges in the Design of Late-Stage Cancer Immunotherapy Studies.

Mick R, Chen TT.

Cancer Immunol Res. 2015 Dec;3(12):1292-8. doi: 10.1158/2326-6066.CIR-15-0260. Review.

PMID: 26644449

 

Serum Immunoregulatory Proteins as Predictors of Overall Survival of Metastatic Melanoma Patients Treated with Ipilimumab.

Koguchi Y, Hoen HM, Bambina SA, Rynning MD, Fuerstenberg RK, Curti BD, Urba WJ, Milburn C, Bahjat FR, Korman AJ, Bahjat KS.

Cancer Res. 2015 Dec 1;75(23):5084-92. doi: 10.1158/0008-5472.CAN-15-2303.

PMID: 26627641

 

Use of Real-World Claim Databases to Assess Prevalence of Comorbid Conditions Relevant to the Treatment of Chronic Myelogenous Leukemia Based on National Comprehensive Network Treatment Guidelines.

Jabbour E, Makenbaeva D, Lingohr-Smith M, Lin J.

Clin Lymphoma Myeloma Leuk. 2015 Dec;15(12):797-802. doi: 10.1016/j.clml.2015.09.008.

PMID: 26603185

 

Asunaprevir: A Review of Preclinical and Clinical Pharmacokinetics and Drug-Drug Interactions.

Eley T, Garimella T, Li W, Bertz RJ.

Clin Pharmacokinet. 2015 Dec;54(12):1205-22. doi: 10.1007/s40262-015-0299-6. Review.

PMID: 26177803

 

Cost-effectiveness Analysis of Apixaban against Warfarin for Stroke Prevention in Patients with Nonvalvular Atrial Fibrillation in Japan.

Kamae I, Hashimoto Y, Koretsune Y, Tanahashi N, Murata T, Phatak H, Liu LZ, Tang AC, Feng Wang P, Okumura K.

Clin Ther. 2015 Dec 1;37(12):2837-51. doi: 10.1016/j.clinthera.2015.10.007.

PMID: 26608819

 

Hypoglycaemic episodes in patients with type 2 diabetes--risk factors and associations with patient-reported outcomes: The PANORAMA Study.

Simon D, de Pablos-Velasco P, Parhofer KG, Gönder-Frederick L, Duprat Lomon I, Vandenberghe H, Eschwège E, Bradley C.

Diabetes Metab. 2015 Dec;41(6):470-9. doi: 10.1016/j.diabet.2015.08.007.

PMID: 26455870

 

Health state utilities associated with attributes of treatments for hepatitis C.

Matza LS, Sapra SJ, Dillon JF, Kalsekar A, Davies EW, Devine MK, Jordan JB, Landrian AS, Feeny DH.

Eur J Health Econ. 2015 Dec;16(9):1005-18. doi: 10.1007/s10198-014-0649-6.

PMID: 25481796

 

Apixaban Reduces Hospitalizations in Patients With Venous Thromboembolism: An Analysis of the Apixaban for the Initial Management of Pulmonary Embolism and Deep-Vein Thrombosis as First-Line Therapy (AMPLIFY) Trial.

Liu X, Johnson M, Mardekian J, Phatak H, Thompson J, Cohen AT.

J Am Heart Assoc. 2015 Dec 1;4(12). pii: e002340. doi: 10.1161/JAHA.115.002340.

PMID: 26627879

 

Blood Pressure Control and Risk of Stroke or Systemic Embolism in Patients With Atrial Fibrillation: Results From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial.

Rao MP, Halvorsen S, Wojdyla D, Thomas L, Alexander JH, Hylek EM, Hanna M, Bahit MC, Lopes RD, De Caterina R, Erol C, Goto S, Lanas F, Lewis BS, Husted S, Gersh BJ, Wallentin L, Granger CB; Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Steering Committee and Investigators..

J Am Heart Assoc. 2015 Dec 1;4(12). pii: e002015. doi: 10.1161/JAHA.115.002015.

PMID: 26627878

 

The Risk for Cardiovascular Events Associated with Hyperlipdemia among Patients with and Without Rheumatoid Arthritis.

Nadkarni A, You M, Resuehr H, Curtis JR.

J Arthritis. 2015 Dec;4(4). pii: 178.

PMID: 26835182

 

Development of a Model Protein Interaction Pair as a Benchmarking Tool for the Quantitative Analysis of 2-Site Protein-Protein Interactions.

Yamniuk AP, Newitt JA, Doyle ML, Arisaka F, Giannetti AM, Hensley P, Myszka DG, Schwarz FP, Thomson JA, Eisenstein E.

J Biomol Tech. 2015 Dec;26(4):125-41. doi: 10.7171/jbt.15-2604-001.

PMID: 26543437

 

Comparison of Ensemble and Single Molecule Methods for Particle Characterization and Binding Analysis of a PEGylated Single-Domain Antibody.

Schneeweis LA, Obenauer-Kutner L, Kaur P, Yamniuk AP, Tamura J, Jaffe N, O'Mara BW, Lindsay S, Doyle M, Bryson J.

J Pharm Sci. 2015 Dec;104(12):4015-24. doi: 10.1002/jps.24624.

PMID: 26343417

 

Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699.

Yang Z, Wang H, Salcedo TW, Suchard SJ, Xie JH, Schneeweis LA, Fleener CA, Calore JD, Shi R, Zhang SX, Rodrigues AD, Car BD, Marathe PH, Nadler SG.

J Pharmacol Exp Ther. 2015 Dec;355(3):506-15. doi: 10.1124/jpet.115.227249.

PMID: 26442523

 

Memory re-differentiation and reduced lymphocyte activation in chronic HCV-infected patients receiving direct-acting antivirals.

Burchill MA, Golden-Mason L, Wind-Rotolo M, Rosen HR.

J Viral Hepat. 2015 Dec;22(12):983-91. doi: 10.1111/jvh.12465.

PMID: 26482547

 

Elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma: final phase 2 results from the randomised, open-label, phase 1b-2 dose-escalation study.

Richardson PG, Jagannath S, Moreau P, Jakubowiak AJ, Raab MS, Facon T, Vij R, White D, Reece DE, Benboubker L, Zonder J, Tsao LC, Anderson KC, Bleickardt E, Singhal AK, Lonial S; 1703 study investigators..

Lancet Haematol. 2015 Dec;2(12):e516-27. doi: 10.1016/S2352-3026(15)00197-0.

PMID: 26686406

 

Cause of death in patients with atrial fibrillation admitted to French hospitals in 2012: a nationwide database study.

Fauchier L, Samson A, Chaize G, Gaudin AF, Vainchtock A, Bailly C, Cotté FE.

Open Heart. 2015 Dec 1;2(1):e000290. doi: 10.1136/openhrt-2015-000290.

PMID: 26688739

 

Efavirenz Capsule Sprinkle and Liquid Formulations With Didanosine and Emtricitabine in HIV-1-infected Infants and Children 3 Months to 6 Years of Age: Study AI266-922.

Pavia-Ruz N, Rossouw M, Sáez-Llorens X, Bunupuradah T, Taylor M, Yang R, Sevinsky H, Krystal M, Lataillade M, Seekins D, Biguenet S.

Pediatr Infect Dis J. 2015 Dec;34(12):1355-60. doi: 10.1097/INF.0000000000000913.

PMID: 26379163

 

Benefit-Risk Assessment, Communication, and Evaluation (BRACE) throughout the life cycle of therapeutic products: overall perspective and role of the pharmacoepidemiologist.

Radawski C, Morrato E, Hornbuckle K, Bahri P, Smith M, Juhaeri J, Mol P, Levitan B, Huang HY, Coplan P, Li H; BRACE Special Interest Group..

Pharmacoepidemiol Drug Saf. 2015 Dec;24(12):1233-40. doi: 10.1002/pds.3859. Review.

PMID: 26456379

 

The role of ADME pharmacogenomics in early clinical trials: perspective of the Industry Pharmacogenomics Working Group (I-PWG).

Tremaine L, Brian W, DelMonte T, Francke S, Groenen P, Johnson K, Li L, Pearson K, Marshall JC.

Pharmacogenomics. 2015 Dec;16(18):2055-67. doi: 10.2217/pgs.15.141. Review.

PMID: 26616152

 

Caring for relatives with lung cancer in Europe: an evaluation of caregivers' experience.

Jassem J, Penrod JR, Goren A, Gilloteau I.

Qual Life Res. 2015 Dec;24(12):2843-52. doi: 10.1007/s11136-015-1028-1.

PMID: 26068731

 

Potential seminal transport of pharmaceuticals to the conceptus.

Scialli AR, Bailey G, Beyer BK, Bøgh IB, Breslin WJ, Chen CL, DeLise AM, Hui JY, Moffat GJ, Stewart J, Thompson KE.

Reprod Toxicol. 2015 Dec;58:213-21. doi: 10.1016/j.reprotox.2015.10.015. Review.

PMID: 26545974

 

Pregnancy outcomes following exposure to abatacept during pregnancy.

Kumar M, Ray L, Vemuri S, Simon TA.

Semin Arthritis Rheum. 2015 Dec;45(3):351-6. doi: 10.1016/j.semarthrit.2015.06.016.

PMID: 26210783

 

Erratum to: Iron metabolism and iron supplementation in cancer patients.

Ludwig H, Evstatiev R, Kornek G, Aapro M, Bauernhofer T, Buxhofer-Ausch V, Fridrik M, Geissler D, Geissler K, Gisslinger H, Koller E, Kopetzky G, Lang A, Rumpold H, Steurer M, Kamali H, Link H.

Wien Klin Wochenschr. 2015 Dec;127(23-24):920-1. doi: 10.1007/s00508-015-0893-5. No abstract available.

PMID: 26613899

 

Iron metabolism and iron supplementation in cancer patients.

Ludwig H, Evstatiev R, Kornek G, Aapro M, Bauernhofer T, Buxhofer-Ausch V, Fridrik M, Geissler D, Geissler K, Gisslinger H, Koller E, Kopetzky G, Lang A, Rumpold H, Steurer M, Kamali H, Link H.

Wien Klin Wochenschr. 2015 Dec;127(23-24):907-19. doi: 10.1007/s00508-015-0842-3. Review. Erratum in: Wien Klin Wochenschr. 2015 Dec;127(23-24):920-1.

PMID: 26373748

 

Impact of moisture and magnesium stearate functionality on manufacturability of wet granulated metformin tablets.

Kestur U, Desai D, Sharif S, Wong B, Guo H, Tang D, Chan S.

Pharm Dev Technol. 2015 Nov 29:1-9. [Epub ahead of print]

PMID: 26616157

 

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).

Qiao JX, Wang TC, Adam LP, Chen AY, Taylor DS, Yang RZ, Zhuang S, Sleph PG, Li JP, Li D, Yin X, Chang M, Chen XQ, Shen H, Li J, Smith D, Wu DR, Leith L, Harikrishnan LS, Kamau MG, Miller MM, Bilder D, Rampulla R, Li YX, Xu C, Lawrence RM, Poss MA, Levesque P, Gordon DA, Huang CS, Finlay HJ, Wexler RR, Salvati ME.

J Med Chem. 2015 Nov 25;58(22):9010-26. doi: 10.1021/acs.jmedchem.5b01363.

PMID: 26524347

 

Polymorphisms near the IFNL3 Gene Associated with HCV RNA Spontaneous Clearance and Hepatocellular Carcinoma Risk.

Lee MH, Yang HI, Lu SN, Lin YJ, Jen CL, Wong KH, Chan SY, Chen LC, Wang LY, L'Italien G, Yuan Y, Chen CJ.

Sci Rep. 2015 Nov 25;5:17030. doi: 10.1038/srep17030.

PMID: 26602024

 

 Impact of Genetic Mutations and Health Plan Access to Therapies on Treatment Response and Drug Costs Related to Tyrosine Kinase Inhibitor Treatment Among Patients With Chronic Myelogenous Leukemia.

Jabbour E, Makenbaeva D, Lingohr-Smith M, Lin J.

Am J Clin Oncol. 2015 Nov 17. [Epub ahead of print]

PMID: 26580245

 

 Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE).

Boy KM, Guernon JM, Wu YJ, Zhang Y, Shi J, Zhai W, Zhu S, Gerritz SW, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Good AC, Grace JE, Lentz KA, Olson RE, Macor JE, Thompson LA 3rd.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5040-7. doi: 10.1016/j.bmcl.2015.10.031.

PMID: 26497283

 

Applications of Fluorine in Medicinal Chemistry.

Gillis EP, Eastman KJ, Hill MD, Donnelly DJ, Meanwell NA.

J Med Chem. 2015 Nov 12;58(21):8315-59. doi: 10.1021/acs.jmedchem.5b00258. Review.

PMID: 26200936

 

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.

Sun JH, O'Boyle DR 2nd, Fridell RA, Langley DR, Wang C, Roberts SB, Nower P, Johnson BM, Moulin F, Nophsker MJ, Wang YK, Liu M, Rigat K, Tu Y, Hewawasam P, Kadow J, Meanwell NA, Cockett M, Lemm JA, Kramer M, Belema M, Gao M.

Nature. 2015 Nov 12;527(7577):245-8. doi: 10.1038/nature15711.

PMID: 26536115

 

Comparison of pharmaceutical formulations: ATR-FTIR spectroscopic imaging to study drug-carrier interactions.

Ewing AV, Biggart GD, Hale CR, Clarke GS, Kazarian SG.

Int J Pharm. 2015 Nov 10;495(1):112-21. doi: 10.1016/j.ijpharm.2015.08.068.

PMID: 26319636

 

Effect of milling temperatures on surface area, surface energy and cohesion of pharmaceutical powders.

Shah UV, Wang Z, Olusanmi D, Narang AS, Hussain MA, Tobyn MJ, Heng JY.

Int J Pharm. 2015 Nov 10;495(1):234-40. doi: 10.1016/j.ijpharm.2015.08.061.

PMID: 26315119

 

Drug usage analysis and health care resources consumption in naïve patients with rheumatoid arthritis.

Sangiorgi D, Benucci M, Nappi C, Perrone V, Buda S, Degli Esposti L.

Biologics. 2015 Nov 6;9:119-27. doi: 10.2147/BTT.S89286.

PMID: 26604680

 

Cost-effectiveness of dapagliflozin versus DPP-4 inhibitors as an add-on to Metformin in the Treatment of Type 2 Diabetes Mellitus from a UK Healthcare System Perspective.

Charokopou M, McEwan P, Lister S, Callan L, Bergenheim K, Tolley K, Postema R, Townsend R, Roudaut M.

BMC Health Serv Res. 2015 Nov 5;15:496. doi: 10.1186/s12913-015-1139-y.

PMID: 26541516

 

Inhibition of in vivo [(3)H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice.

Fernandes A, Wojcik T, Baireddy P, Pieschl R, Newton A, Tian Y, Hong Y, Bristow L, Li YW.

Eur J Pharmacol. 2015 Nov 5;766:1-8. doi: 10.1016/j.ejphar.2015.08.044.

PMID: 26325093

 

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma.

Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, Castellano D, Choueiri TK, Gurney H, Donskov F, Bono P, Wagstaff J, Gauler TC, Ueda T, Tomita Y, Schutz FA, Kollmannsberger C, Larkin J, Ravaud A, Simon JS, Xu LA, Waxman IM, Sharma P; CheckMate 025 Investigators..

N Engl J Med. 2015 Nov 5;373(19):1803-13. doi: 10.1056/NEJMoa1510665.

PMID: 26406148

 

Hepatic Disposition of Gemfibrozil and Its Major Metabolite Gemfibrozil 1-O-β-Glucuronide.

Kimoto E, Li R, Scialis RJ, Lai Y, Varma MV.

Mol Pharm. 2015 Nov 2;12(11):3943-52. doi: 10.1021/acs.molpharmaceut.5b00411.

PMID: 26378985

 

Development of a Generic Anti-PEG Antibody Assay Using BioScale's Acoustic Membrane MicroParticle Technology.

Dong H, Mora JR, Brockus C, Chilewski SD, Dodge R, Merrifield C, Dickerson WM, DeSilva B.

AAPS J. 2015 Nov;17(6):1511-6. doi: 10.1208/s12248-015-9799-4.

PMID: 26139446

 

Clinical features of pulmonary arterial hypertension in patients receiving dasatinib.

Shah NP, Wallis N, Farber HW, Mauro MJ, Wolf RA, Mattei D, Guha M, Rea D, Peacock A.

Am J Hematol. 2015 Nov;90(11):1060-4. doi: 10.1002/ajh.24174. Review.

PMID: 26284693

 

Long-term Survival with Ipilimumab: Experience from a National Expanded Access Program for Patients with Melanoma.

Krajsová I, Arenberger P, Lakomý R, Kubala E, Březinová I, Poprach A, Šťastný M, Mužík J, Melichar B.

Anticancer Res. 2015 Nov;35(11):6303-10.

PMID: 26504067

 

Application of Low- and Mid-Frequency Raman Spectroscopy to Characterize the Amorphous-Crystalline Transformation of Indomethacin.

Larkin PJ, Wasylyk J, Raglione M.

Appl Spectrosc. 2015 Nov;69(11):1217-28. doi: 10.1366/15-07926.

PMID: 26647045

 

Discrepancy between guidelines for stroke prevention in atrial fibrillation and practice patterns in primary care. The nationwide French AFIGP survey.

Sabouret P, Bricard M, Hermann MA, Cotté FE, Deret-Bixio L, Rushton-Smith S.

Arch Cardiovasc Dis. 2015 Nov;108(11):544-53. doi: 10.1016/j.acvd.2015.05.005.

PMID: 26113478

  

Using the Effects of Youngsters' Eyesight on Quality of Life Questionnaire to Measure Visual Outcomes in Children With Uveitis.

Angeles-Han ST, Yeh S, McCracken C, Jenkins K, Stryker D, Myoung E, Vogler LB, Rouster-Stevens K, Lambert SR, Harrison MJ, Prahalad S, Drews-Botsch C.

Arthritis Care Res (Hoboken). 2015 Nov;67(11):1513-20. doi: 10.1002/acr.22627.

PMID: 26037544

 

Subvisible (2-100 μm) particle analysis during biotherapeutic drug product development: Part 2, experience with the application of subvisible particle analysis.

Corvari V, Narhi LO, Spitznagel TM, Afonina N, Cao S, Cash P, Cecchini I, DeFelippis MR, Garidel P, Herre A, Koulov AV, Lubiniecki T, Mahler HC, Mangiagalli P, Nesta D, Perez-Ramirez B, Polozova A, Rossi M, Schmidt R, Simler R, Singh S, Weiskopf A, Wuchner K.

Biologicals. 2015 Nov;43(6):457-73. doi: 10.1016/j.biologicals.2015.07.011. Review.

PMID: 26324466

 

Pseudosaccharin amines as potent and selective KV1.5 blockers.

Lloyd J, Finlay HJ, Kover A, Johnson J, Pi Z, Jiang J, Neels J, Cavallaro C, Wexler R, Conder ML, Shi H, Li D, Sun H, Chimalakonda A, Huang C, Salvati M, Levesque P.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4983-6. doi: 10.1016/j.bmcl.2015.02.066.

PMID: 25801931

 

Development of robust antibody purification by optimizing protein-A chromatography in combination with precipitation methodologies.

Chollangi S, Parker R, Singh N, Li Y, Borys M, Li Z.

Biotechnol Bioeng. 2015 Nov;112(11):2292-304. doi: 10.1002/bit.25639.

PMID: 25950654

 

Caprylic acid-induced impurity precipitation from protein A capture column elution pool to enable a two-chromatography-step process for monoclonal antibody purification.

Zheng J, Wang L, Twarowska B, Laino S, Sparks C, Smith T, Russell R, Wang M.

Biotechnol Prog. 2015 Nov-Dec;31(6):1515-25. doi: 10.1002/btpr.2154.

PMID: 26280674

 

Phase II study of ipilimumab monotherapy in Japanese patients with advanced melanoma.

Yamazaki N, Kiyohara Y, Uhara H, Fukushima S, Uchi H, Shibagaki N, Tsutsumida A, Yoshikawa S, Okuyama R, Ito Y, Tokudome T.

Cancer Chemother Pharmacol. 2015 Nov;76(5):997-1004. doi: 10.1007/s00280-015-2873-x.

PMID: 26410424

 

Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma.

Yamazaki N, Uhara H, Fukushima S, Uchi H, Shibagaki N, Kiyohara Y, Tsutsumida A, Namikawa K, Okuyama R, Otsuka Y, Tokudome T.

Cancer Chemother Pharmacol. 2015 Nov;76(5):969-75. doi: 10.1007/s00280-015-2870-0.

PMID: 26407818

 

Cost-effectiveness of Apixaban Compared With Edoxaban for Stroke Prevention in Nonvalvular Atrial Fibrillation.

Lip GY, Lanitis T, Kongnakorn T, Phatak H, Chalkiadaki C, Liu X, Kuznik A, Lawrence J, Dorian P.

Clin Ther. 2015 Nov 1;37(11):2476-2488.e27. doi: 10.1016/j.clinthera.2015.09.005.

PMID: 26477648

 

Stroke associated with discontinuation of warfarin therapy for atrial fibrillation.

Spivey CA, Liu X, Qiao Y, Mardekian J, Parker RB, Phatak H, Masseria C, Kachroo S, Abdulsattar Y, Wang J.

Curr Med Res Opin. 2015 Nov;31(11):2021-9. doi: 10.1185/03007995.2015.1082995.

PMID: 26390258

 

Randomized, Double-Blind Trial of Triple Therapy With Saxagliptin Add-on to Dapagliflozin Plus Metformin in Patients With Type 2 Diabetes.

Matthaei S, Catrinoiu D, Celiński A, Ekholm E, Cook W, Hirshberg B, Chen H, Iqbal N, Hansen L.

Diabetes Care. 2015 Nov;38(11):2018-24. doi: 10.2337/dc15-0811.

PMID: 26324329

 

Randomized, Double-Blind, Phase 3 Trial of Triple Therapy With Dapagliflozin Add-on to Saxagliptin Plus Metformin in Type 2 Diabetes.

Mathieu C, Ranetti AE, Li D, Ekholm E, Cook W, Hirshberg B, Chen H, Hansen L, Iqbal N.

Diabetes Care. 2015 Nov;38(11):2009-17. doi: 10.2337/dc15-0779.

PMID: 26246458

 

GPCR profiling: from hits to leads and from genotype to phenotype.

Cvijic ME, Sum CS, Alt A, Zhang L.

Drug Discov Today Technol. 2015 Nov;18:30-7. doi: 10.1016/j.ddtec.2015.10.005. Review.

PMID: 26723890

 

Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake.

Morse BL, Cai H, MacGuire JG, Fox M, Zhang L, Zhang Y, Gu X, Shen H, Dierks EA, Su H, Luk CE, Marathe P, Shu YZ, Humphreys WG, Lai Y.

Drug Metab Dispos. 2015 Nov;43(11):1788-94. doi: 10.1124/dmd.115.065946.

PMID: 26341276

 

Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.

Talbott RL, Borzilleri RM, Chaudhry C, Fargnoli J, Shen H, Fairchild C, Barnhart B, Ortega M, McDonagh TE, Vuppugalla R, Vite GD, Hunt JT, Gottardis M, Naglich JG.

Exp Cell Res. 2015 Nov 1;338(2):251-60. doi: 10.1016/j.yexcr.2015.08.011.

PMID: 26302264

 

Hepatitis C virus drug resistance-associated substitutions: State of the art summary.

Lontok E, Harrington P, Howe A, Kieffer T, Lennerstrand J, Lenz O, McPhee F, Mo H, Parkin N, Pilot-Matias T, Miller V.

Hepatology. 2015 Nov;62(5):1623-32. doi: 10.1002/hep.27934. Review.

PMID: 26095927

 

Comparative efficacy and safety of daclatasvir/asunaprevir versus IFN-based regimens in genotype 1b hepatitis C virus infection.

Signorovitch JE, Betts KA, Song Y, Sorg RA, Li J, Behl AS, Kalsekar A.

J Comp Eff Res. 2015 Nov;4(6):593-605. doi: 10.2217/cer.15.33. Review.

PMID: 26159375

 

Peginterferon Lambda-1a Is Associated with a Low Incidence of Autoimmune Thyroid Disease in Chronic Hepatitis C.

Fredlund P, Hillson J, Gray T, Shemanski L, Dimitrova D, Srinivasan S.

J Interferon Cytokine Res. 2015 Nov;35(11):841-3. doi: 10.1089/jir.2014.0233.

PMID: 26376344

 

Scale Up of Pan Coating Process Using Quality by Design Principles.

Agrawal AM, Pandey P.

J Pharm Sci. 2015 Nov;104(11):3589-611. doi: 10.1002/jps.24582. Review.

PMID: 26202540

 

In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa.

Wong PC, Quan ML, Watson CA, Crain EJ, Harpel MR, Rendina AR, Luettgen JM, Wexler RR, Schumacher WA, Seiffert DA.

J Thromb Thrombolysis. 2015 Nov;40(4):416-23. doi: 10.1007/s11239-015-1258-7.

PMID: 26249722

 

The contribution of apixaban renal clearance to total clearance.

Frost C, Boyd RA.

J Thromb Thrombolysis. 2015 Nov;40(4):521-2. doi: 10.1007/s11239-015-1220-8. No abstract available.

PMID: 25962516

 

Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial.

Coric V, Salloway S, van Dyck CH, Dubois B, Andreasen N, Brody M, Curtis C, Soininen H, Thein S, Shiovitz T, Pilcher G, Ferris S, Colby S, Kerselaers W, Dockens R, Soares H, Kaplita S, Luo F, Pachai C, Bracoud L, Mintun M, Grill JD, Marek K, Seibyl J, Cedarbaum JM, Albright C, Feldman HH, Berman RM.

JAMA Neurol. 2015 Nov;72(11):1324-33. doi: 10.1001/jamaneurol.2015.0607.

PMID: 26414022

 

Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder.

Arion D, Corradi JP, Tang S, Datta D, Boothe F, He A, Cacace AM, Zaczek R, Albright CF, Tseng G, Lewis DA.

Mol Psychiatry. 2015 Nov;20(11):1397-405. doi: 10.1038/mp.2014.171.

PMID: 25560755

 

Long-term virologic outcomes following bariatric surgery in patients with HIV.

Zivich S, Cauterucci M, Allen S, Vetter M, Vinnard C.

Obes Res Clin Pract. 2015 Nov-Dec;9(6):633-5. doi: 10.1016/j.orcp.2015.09.002.

PMID: 26411387

 

Cost-Effectiveness of Apixaban Versus Other Noacs And Warfarin, During Hospitalization In The Private Brazilian Health System.

Tanaka S, Preto MC, Bernardino G, Nogueira F, Ferreira CN, Donato BM.

Value Health. 2015 Nov;18(7):A830. doi: 10.1016/j.jval.2015.09.312. No abstract available.

PMID: 26534432

 

Costo - Efectividad De Apixaban Con Otros Noacs (Dabigatran Y Rivaroxaban) En El Tratamiento De La Fibrilacion Auricular No Valvular (Fanv) En Pacientes De La Seguridad Social De Perú.

Sanabria C, Cabrejos J, Olortegui A, Guevara C, Garrido Lecca S.

Value Health. 2015 Nov;18(7):A829. doi: 10.1016/j.jval.2015.09.308. No abstract available.

PMID: 26534427

 

Cost-Effectiveness of Apixaban Versus Other New Oral Anticoagulants And Warfarin for Stroke Prevention In Atrial Fibrillation In Venezuela.

Fernández Ávila Y, Garcia KC, Garrido Lecca S, Donato BM, Juarez-Garcia A.

Value Health. 2015 Nov;18(7):A829. doi: 10.1016/j.jval.2015.09.309. No abstract available.

PMID: 26534424

 

The Relative Clinical and Economic Value of Ipilimumab in the Treatment of Metastatic Melanoma Versus Other Anti-Cancer Agents for Metastatic Diseases from a Brazilian Private Health Care System Perspective.

Stefani S, Tanaka S, Araujo R, Chagas K, Bernardino G, Donato BM.

Value Health. 2015 Nov;18(7):A819. doi: 10.1016/j.jval.2015.09.250. No abstract available.

PMID: 26534369

 

Apixaban In Patients With Atrial Fibrillation: Patient Characteristics Of The Latin America Cohort From A Multinational Clinical Trial.

Avezum A, Bahit MC, Hermosillo JA, Zanetti FL, Perafan P, Juarez-Garcia A, Vulcano C, Cubillos LA, Korenblat Donato BM.

Value Health. 2015 Nov;18(7):A809. doi: 10.1016/j.jval.2015.09.097. No abstract available.

PMID: 26534313

 

Simulated Treatment Comparison of Time-To-Event (And Other Non-Linear) Outcomes.

Ishak KJ, Rael M, Phatak H, Masseria C, Lanitis T.

Value Health. 2015 Nov;18(7):A719. doi: 10.1016/j.jval.2015.09.2723. No abstract available.

PMID: 26534029

 

A Comparison of Three Survival Models to Estimate The Cost-Effectiveness of Cancer Immunotherapy In The Treatment of Advanced Melanoma.

Bohensky M, Gorelik A, Kim H, Liew D.

Value Health. 2015 Nov;18(7):A699. doi: 10.1016/j.jval.2015.09.2613. No abstract available.

PMID: 26533919

 

Societal Burden And Impact On Health Related Quality Of Life (Hrqol) Of Non-Small Cell Lung Cancer (Nsclc) In Europe.

Enstone A, Panter C, Manley Daumont M, Miles R.

Value Health. 2015 Nov;18(7):A690. doi: 10.1016/j.jval.2015.09.2563. No abstract available.

PMID: 26533869

  

Economic Evaluation of Dasatynib In Treatment of Adult Patients With Philadelphia Chromosome Positive (Ph+) Acute Lymbphoblastic Leukemia (All) With Resistance or Intolerance to Prior Therapy In Poland.

Mucha J, Stelmachowski J, Walczak J, Pieniazek I, Obrzut G, Labak-Klimasara M.

Value Health. 2015 Nov;18(7):A671-2. doi: 10.1016/j.jval.2015.09.1975. No abstract available.

PMID: 26533764

 

Budget Impact Analysis of Dasatynib In Treatment of Adult Patients With Philadelphia Chromosome Positive (Ph+) Acute Lymbphoblastic Leukemia (All) With Resistance or Intolerance to Prior Therapy In Poland.

Mucha J, Stelmachowski J, Walczak J, Pieniazek I, Labak-Klimasara M, Obrzut G.

Value Health. 2015 Nov;18(7):A663. doi: 10.1016/j.jval.2015.09.2412. No abstract available.

PMID: 26533717

 

Cost-Effectiveness of Abatacept Compared to Adalimumab In Italy Based on A Head-To-Head Outcomes Study In Rheumatoid Arthritis.

Gaultney J, Nappi C, Benucci M, Iannazzo S, Sion K, Alemao E, Sabater J.

Value Health. 2015 Nov;18(7):A644. doi: 10.1016/j.jval.2015.09.2302. No abstract available.

PMID: 26533615

 

The Efficacy and Safety of Abatacept, Adalimumab, Etanercept And Tocilizumab are Comparable In Polyarticular Juvenile Idiopathic Arthritis.

Rathi H, Pennington B, Amadi A, Lister S, Nanuwa K.

Value Health. 2015 Nov;18(7):A636. doi: 10.1016/j.jval.2015.09.2258. No abstract available.

PMID: 26533567

 

Modeling The Cost-Effectiveness of The All Oral, Direct-Acting Antiviral Regimen Daclatasvir Plus Sofosbuvir In Patients Co-Infected With Hepatitis C Virus (Hcv) And Hiv.

McEwan P, Ward T, Webster S, Kalsekar A, Brenner M, Yuan Y.

Value Health. 2015 Nov;18(7):A628. doi: 10.1016/j.jval.2015.09.2213. No abstract available.

PMID: 26533528

 

Association between Weight Change, Diabetes-Related Healthcare Costs, and HbA1c among Patients with Type 2 Diabetes.

Mukherjee J, Sternhufvud C, Smith N, Bell K, Stott-Miller M, Johnston S.

Value Health. 2015 Nov;18(7):A605-6. doi: 10.1016/j.jval.2015.09.2088. No abstract available.

PMID: 26533397

 

Cost of Achieving Combined Improvements in HbA1c and Weight without Hypoglycaemia over 4 Years in a Post-Hoc Analysis of Dapagliflozin + MET Vs Glipizide + MET.

Johansen P, Mukherjee J, Sörstadius E, Sternhufvud C.

Value Health. 2015 Nov;18(7):A604-5. doi: 10.1016/j.jval.2015.09.2083. No abstract available.

PMID: 26533390

 

Cost Effectiveness Analysis of The Use of Daclatasvir for the Treatment of Hepatitis C Virus (Hcv) Genotypes 3 in Cirrhotic Patients Within the Italian National Health Service.

Restelli U, Bonfanti M, Alberti A, Lazzarin A, Nappi C, Croce D.

Value Health. 2015 Nov;18(7):A587. doi: 10.1016/j.jval.2015.09.1498. No abstract available.

PMID: 26533297

 

Direct Medical Cost Associated With The Diagnosis and Treatment of Patients With Chronic Hepatitis-B In Three Large Metropolitan Cities In India - A Pilot Study.

Marfatia S, Gupta K, Mukherjee A, Mattoo V.

Value Health. 2015 Nov;18(7):A581-2. doi: 10.1016/j.jval.2015.09.1945. No abstract available.

PMID: 26533268

 

Budget Impact Analysis of The Use of Daclatasvir for The Treatment of Hepatitis C Virus (Hcv) Genotypes 3, In The Italian Setting.

Restelli U, Bonfanti M, Alberti A, Lazzarin A, Nappi C, Croce D.

Value Health. 2015 Nov;18(7):A580. doi: 10.1016/j.jval.2015.09.1935. No abstract available.

PMID: 26533258

 

Epidemiology of Hepatitis C Patients In Italian Local Health Units (Lhus).

Degli Esposti L, Sangiorgi D, Buda S, Crovato E, Nappi C, Lefevre C.

Value Health. 2015 Nov;18(7):A579. doi: 10.1016/j.jval.2015.09.1928. No abstract available.

PMID: 26533255

 

Daclatasvir +Asunaprevir Versus Sofosbuvir/Ledipasvir for The Treatment of Chronic Hepatitis C Genotype 1 In Japanese Patients: A Matching-Adjusted Indirect Comparison.

Swallow E, Kelley C, Ristovska L, Signorovitch JE, Kalsekar A, Wygant G, McPhee F.

Value Health. 2015 Nov;18(7):A576. doi: 10.1016/j.jval.2015.09.1915. No abstract available.

PMID: 26533237

 

Clinical And Health-Economic Criteria for the Assessment of New Immune-Oncologic Drugs in Spain.

López-Bastida J, Oliva Moreno J, Sánchez Martínez F, González García P.

Value Health. 2015 Nov;18(7):A485. doi: 10.1016/j.jval.2015.09.1329. No abstract available.

PMID: 26532723

 

Patient Count Forecasts of Advanced Non-Small Cell Lung Cancer: Results from the UK, Germany, France, Italy and Spain (Eu-5).

Kish JK, O'Day K, Manley-Daumont M, Campbell DJ, Penrod J.

Value Health. 2015 Nov;18(7):A484. doi: 10.1016/j.jval.2015.09.1324. No abstract available.

PMID: 26532716

 

Progressive Disease Does Not Impact Hrqol In Patients Receiving Nivolumab For The Treatment Of Unresectable Or Metastatic Melanoma.

Harrison JP, Kim H.

Value Health. 2015 Nov;18(7):A475. doi: 10.1016/j.jval.2015.09.1271. No abstract available.

PMID: 26532667

 

Eastern Cooperative Oncology Group (Ecog) Performance Status (Ps) Is An Independent Predictor Of Hrqol In Unresectable Or Metastatic Melanoma.

Harrison JP, Kim H.

Value Health. 2015 Nov;18(7):A474. doi: 10.1016/j.jval.2015.09.1267. No abstract available.

PMID: 26532662

 

Predictors Of Utility Over Time Among Patients With Treatment-Naïve Advanced Melanoma From The Phase 3 Checkmate 066 Trial.

Paly V, Colby C, Gilloteau I, Exuzides A, Briggs A.

Value Health. 2015 Nov;18(7):A474. doi: 10.1016/j.jval.2015.09.1265. No abstract available.

PMID: 26532660

 

Understanding The Impact Of Patient And Physician Preferences In Personalized Treatment For Melanoma Using A Discrete Choice Experiment.

Stenehjem D, Korytowsky B, Oderda G, Wanishayakorn T, Bauer H, Brixner D.

Value Health. 2015 Nov;18(7):A469-70. doi: 10.1016/j.jval.2015.09.1241. No abstract available.

PMID: 26532636

 

Mapping Health State Utility Values From Eortc Data Collected From A Clinical Trial Population With Relapsed/Refractory Multiple Myeloma.

Quinn C, Hirji I, Shingler SL, Davis C.

Value Health. 2015 Nov;18(7):A468. doi: 10.1016/j.jval.2015.09.1233. No abstract available.

PMID: 26532629

 

Treatment Sequencing Patterns And Costs of Care in Patients with Relapsed/Refractory Multiple Myeloma.

Potluri R, Farr AM, Hirji I, Davis C, Bhandari H, Oukessou A.

Value Health. 2015 Nov;18(7):A450. doi: 10.1016/j.jval.2015.09.1134. No abstract available.

PMID: 26532531

 

Resource Utilization Among Advanced Squamous and non-Squamous non-Small Cell Lung Cancer Patients Receiving Second-Line Treatment in France, Germany, Italy, and Spain: Results of A Retrospective Medical Chart Review.

Solem CT, Penrod JR, Lees M, Manley Daumont M, Macahilig CP, Baeten S, Verleger K, Wilke T.

Value Health. 2015 Nov;18(7):A450. doi: 10.1016/j.jval.2015.09.1133. No abstract available.

PMID: 26532530

 

An Assessment of The Hospitalization Costs of Melanoma in France in the Advanced/Metastatic Setting: the Melissa Study (Melanoma in Hospital Costs Assessment).

de Léotoing L, Combemale P, Fernandes J, Bregman B, Amaz C, Vainchtock A, Gaudin A.

Value Health. 2015 Nov;18(7):A447. doi: 10.1016/j.jval.2015.09.1115. No abstract available.

PMID: 26532513

 

The Relative Efficacy And Safety Of Treatments In Second-Line Management Of Chronic Myeloid Leukaemia: Systematic Review And Network Meta-Analysis Feasibility Study.

Kroes MA, Witkowski MA, Paine A, Zagorska A, Almeida AM.

Value Health. 2015 Nov;18(7):A435. doi: 10.1016/j.jval.2015.09.1047. No abstract available.

PMID: 26532449

 

Overall Survival (Os) And Quality-Of-Life (Qol) Outcomes In Recurrent Or Metastatic Squamous Cell Carcinoma Of The Head And Neck (Scchn): A Systematic Literature Review.

Signorovitch J, Li N, Zhong Y, Shaw J, Dastani H, Orsini L.

Value Health. 2015 Nov;18(7):A433-4. doi: 10.1016/j.jval.2015.09.1040. No abstract available.

PMID: 26532439

 

Overall Survival (Os), Quality Of Life (Qol), And Neurocognitive Function (Nf) In Recurrent Glioblastoma Multiforme (Gbm): A Systematic Literature Review.

Signorovitch J, Li N, Ohashi E, Dastani H, Shaw J, Orsini L.

Value Health. 2015 Nov;18(7):A433. doi: 10.1016/j.jval.2015.09.1036. No abstract available.

PMID: 26532436

 

Persistence To Vitamin-K Antagonists (Vka) And Novel Oral Anticoagulants (Noacs) In Non-Valvular Atrial Fibrillation (Nvaf): An Observational Study Using A Comprehensive Regional Database In Catalonia, Spain.

Lefevre C, Benhaddi H, Lacoin L, Diaz Cuervo H, Lee Y, Evans D, Budd D.

Value Health. 2015 Nov;18(7):A403. doi: 10.1016/j.jval.2015.09.938. No abstract available.

PMID: 26532274

 

Factors Associated With The Duration Of Anticoagulation Therapy Following Acute Vte In England In General Practice: An Observational Study Using Cprd-Hes Databases.

Lacoin L, Ridha E, Lefevre C, Moorthy V, Vasudev M, Lister S, Bird A, Minns I, Evans D, Alikhan R, Bakhai A.

Value Health. 2015 Nov;18(7):A401. doi: 10.1016/j.jval.2015.09.927. No abstract available.

PMID: 26532263

 

Resource Utilisation And Bleeding Events During Anticoagulation Treatment: Real-World Findings From England.

Lister S, Lefevre C, Menown I, Alikhan R, Lacoin L, Bird A, You M, Ridha E, Evans D.

Value Health. 2015 Nov;18(7):A396-7. doi: 10.1016/j.jval.2015.09.899. No abstract available.

PMID: 26532233

 

Cost-Utility Analysis Of Apixaban In The Acute Treatment And Prevention Of Venous Thromboembolism In France.

Stern S, Cotte F, Minacori R, Gosden T, Hamilton M, Phatak H, Quon P.

Value Health. 2015 Nov;18(7):A395. doi: 10.1016/j.jval.2015.09.892. No abstract available.

PMID: 26532232

 

Local Cost Study Of Treatment Of Venous Thromboembolism In Turkey.

Tatar M, Senturk A, Tuna E, Bilginer B, Ulus AT, Buyuktuna N, Hacibedel B, Saribas G.

Value Health. 2015 Nov;18(7):A388-9. doi: 10.1016/j.jval.2015.09.856. No abstract available.

PMID: 26532194

 

Resource Utilization And Treatment Costs Of Stroke In Patients With Non-Valvular Atrial Fibrillation In Spain.

Lefevre C, Benhaddi H, Lacoin L, Diaz Cuervo H, Lee Y, Evans D, Budd D.

Value Health. 2015 Nov;18(7):A388. doi: 10.1016/j.jval.2015.09.852. No abstract available.

PMID: 26532190

 

Medical Cost Of Patients With Non-Valvular Atrial Fibrillation (Nvaf) And Treated With Vitamin K Antagonists (Vkas) According To Inr Control Status In Spain.

Postema R, Bardoulat I, Roset M, Maurel F, Lefevre C, Evans D.

Value Health. 2015 Nov;18(7):A385. doi: 10.1016/j.jval.2015.09.836. No abstract available.

PMID: 26532176

 

Patient Profile of New Users of Novel Oral Anticoagulants in non-Valvular Atrial Fibrillation (Nvaf): Real-World Evidence from Primary Care Data in Germany.

Lefevre C, Johnson M, Maguire A, Collings S, Kloss S, Evans D.

Value Health. 2015 Nov;18(7):A375. doi: 10.1016/j.jval.2015.09.776. No abstract available.

PMID: 26532119

 

Access to Innovative Drugs in Patients with Metastatic Lung Cancer in French Public Hospitals (the Territoire Study).

Scherpereel A, Fernandes J, Cotté F, Blein C, Debieuvre D, Durand-Zaleski I, Gaudin A, Ozan N, Saitta B, Souquet P, Vainchtock A, Westeel V, Chouaïd C.

Value Health. 2015 Nov;18(7):A341. doi: 10.1016/j.jval.2015.09.145. No abstract available.

PMID: 26531933

 

 A Cost Effectiveness Analysis of Nivolumab Compared to Ipilimumab for the Treatment of Braf Wild-Type Advanced Melanoma in Australia.

Bohensky M, Pasupathi K, Gorelik A, Kim H, Harrison JP, Liew D.

Value Health. 2015 Nov;18(7):A340. doi: 10.1016/j.jval.2015.09.138. No abstract available.

PMID: 26531928

 

Partitioned Survival Versus State Transition Modeling in Oncology: a Case Study with Nivolumab in Advanced Melanoma.

Briggs A, Baker TM, Gilloteau I, Orsini L, Wagner S, Paly V.

Value Health. 2015 Nov;18(7):A338. doi: 10.1016/j.jval.2015.09.130. No abstract available.

PMID: 26531916

 

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer.

Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, Barlesi F, Kohlhäufl M, Arrieta O, Burgio MA, Fayette J, Lena H, Poddubskaya E, Gerber DE, Gettinger SN, Rudin CM, Rizvi N, Crinò L, Blumenschein GR Jr, Antonia SJ, Dorange C, Harbison CT, Graf Finckenstein F, Brahmer JR.

N Engl J Med. 2015 Oct 22;373(17):1627-39. doi: 10.1056/NEJMoa1507643.

PMID: 26412456

 

Mono-Oxidation of Bidentate Bis-phosphines in Catalyst Activation: Kinetic and Mechanistic Studies of a Pd/Xantphos-Catalyzed C-H Functionalization.

Ji Y, Plata RE, Regens CS, Hay M, Schmidt M, Razler T, Qiu Y, Geng P, Hsiao Y, Rosner T, Eastgate MD, Blackmond DG.

J Am Chem Soc. 2015 Oct 21;137(41):13272-81. doi: 10.1021/jacs.5b01913.

PMID: 26461028

 

Syn-Selective Synthesis of β-Branched α-Amino Acids by Alkylation of Glycine-Derived Imines with Secondary Sulfonates.

Lou S, McKenna GM, Tymonko SA, Ramirez A, Benkovics T, Conlon DA, González-Bobes F.

Org Lett. 2015 Oct 16;17(20):5000-3. doi: 10.1021/acs.orglett.5b02448.

PMID: 26444227

 

The application of high-resolution mass spectrometry-based data-mining tools in tandem to metabolite profiling of a triple drug combination in humans.

Xing J, Zang M, Zhang H, Zhu M.

Anal Chim Acta. 2015 Oct 15;897:34-44. doi: 10.1016/j.aca.2015.09.034.

PMID: 26515003

 

Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies.

Devasthale P, Wang W, Mignone J, Renduchintala K, Radhakrishnan S, Dhanapal J, Selvaraj J, Kuppusamy R, Pelleymounter MA, Longhi D, Huang N, Flynn N, Azzara AV, Rohrbach K, Devenny J, Rooney S, Thomas M, Glick S, Godonis H, Harvey S, Cullen MJ, Zhang H, Caporuscio C, Stetsko P, Grubb M, Huang C, Zhang L, Freeden C, Murphy BJ, Robl JA, Washburn WN.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4412-8. doi: 10.1016/j.bmcl.2015.09.018.

PMID: 26386604

 

Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor.

Liu C, Lin J, Hynes J, Wu H, Wrobleski ST, Lin S, Dhar TG, Vrudhula VM, Sun JH, Chao S, Zhao R, Wang B, Chen BC, Everlof G, Gesenberg C, Zhang H, Marathe PH, McIntyre KW, Taylor TL, Gillooly K, Shuster DJ, McKinnon M, Dodd JH, Barrish JC, Schieven GL, Leftheris K.

J Med Chem. 2015 Oct 8;58(19):7775-84. doi: 10.1021/acs.jmedchem.5b00839.

PMID: 26359680

 

The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

Ramamurthy V, Yamniuk AP, Lawrence EJ, Yong W, Schneeweis LA, Cheng L, Murdock M, Corbett MJ, Doyle ML, Sheriff S.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1273-81. doi: 10.1107/S2053230X15016416.

PMID: 26457518

 

Effect of an intensive lifestyle intervention on atrial fibrillation risk in individuals with type 2 diabetes: the Look AHEAD randomized trial.

Alonso A, Bahnson JL, Gaussoin SA, Bertoni AG, Johnson KC, Lewis CE, Vetter M, Mantzoros CS, Jeffery RW, Soliman EZ; Look AHEAD Research Group..

Am Heart J. 2015 Oct;170(4):770-777.e5. doi: 10.1016/j.ahj.2015.07.026.

PMID: 26386801

 

The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: results from a multinational, phase IIb, randomized, double-blind, placebo/active-controlled, dose-ranging study.

Weinblatt ME, Mease P, Mysler E, Takeuchi T, Drescher E, Berman A, Xing J, Zilberstein M, Banerjee S, Emery P.

Arthritis Rheumatol. 2015 Oct;67(10):2591-600. doi: 10.1002/art.39249.

PMID: 26138593

 

Long-term safety, efficacy, and quality of life in patients with juvenile idiopathic arthritis treated with intravenous abatacept for up to seven years.

Lovell DJ, Ruperto N, Mouy R, Paz E, Rubio-Pérez N, Silva CA, Abud-Mendoza C, Burgos-Vargas R, Gerloni V, Melo-Gomes JA, Saad-Magalhaes C, Chavez-Corrales J, Huemer C, Kivitz A, Blanco FJ, Foeldvari I, Hofer M, Huppertz HI, Job Deslandre C, Minden K, Punaro M, Block AJ, Giannini EH, Martini A; Pediatric Rheumatology Collaborative Study Group and the Paediatric Rheumatology International Trials Organisation..

Arthritis Rheumatol. 2015 Oct;67(10):2759-70. doi: 10.1002/art.39234.

PMID: 26097215

 

[Cost-effectiveness analysis of dapagliflozin compared to DPP4 inhibitors and other oral antidiabetic drugs in the treatment of type-2 diabetes mellitus in Spain].

Abad Paniagua EJ, Casado Escribano P, Fernández Rodriguez JM, Morales Escobar FJ, Betegón Nicolás L, Sánchez-Covisa J, Brosa M.

Aten Primaria. 2015 Oct;47(8):505-13. doi: 10.1016/j.aprim.2014.11.002. Spanish.

PMID: 25555492

 

Beyond classical derivatization: analyte 'derivatives' in the bioanalysis of endogenous and exogenous compounds.

Barnaby OS, Benitex Y, Cantone JL, McNaney CA, Olah TV, Drexler DM.

Bioanalysis. 2015 Oct;7(19):2501-13. doi: 10.4155/bio.15.171.

PMID: 26466806

 

Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).

Liu Q, Batt DG, Lippy JS, Surti N, Tebben AJ, Muckelbauer JK, Chen L, An Y, Chang C, Pokross M, Yang Z, Wang H, Burke JR, Carter PH, Tino JA.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4265-9. doi: 10.1016/j.bmcl.2015.07.102.

PMID: 26320619

 

The Effectiveness of Tyrosine Kinase Inhibitors and Molecular Monitoring Patterns in Newly Diagnosed Patients With Chronic Myeloid Leukemia in the Community Setting.

Di Bella NJ, Bhowmik D, Bhor M, Yap M, Middlebrook B, Rembert D, Cain Z, Okoro T, Bolinder B, Patt D, Jabbour EJ.

Clin Lymphoma Myeloma Leuk. 2015 Oct;15(10):599-605. doi: 10.1016/j.clml.2015.06.006.

PMID: 26208445

 

Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates.

Huang RY, Deyanova EG, Passmore D, Rangan V, Deshpande S, Tymiak AA, Chen G.

J Am Soc Mass Spectrom. 2015 Oct;26(10):1791-4. doi: 10.1007/s13361-015-1203-1.

PMID: 26122520

 

Dried blood spot analysis without dilution: Application to the LC-MS/MS determination of BMS-986001 in rat dried blood spot.

Yuan L, Schuster A, Shen JX, Garrison-Borowski P, Aubry AF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:201-9. doi: 10.1016/j.jchromb.2015.08.029.

PMID: 26340763

 

Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC-MS/MS approach: Assay development, validation, and a case study.

Liu A, Kozhich A, Passmore D, Gu H, Wong R, Zambito F, Rangan VS, Myler H, Aubry AF, Arnold ME, Wang J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:54-62. doi: 10.1016/j.jchromb.2015.08.007.

PMID: 26310897

 

Comparison of different QT interval correction methods for heart rate and QT beat-to-beat method in a thorough QT study of triple monoamine reuptake inhibitor BMS-820836.

Zheng M, Burt D, Chan W, Hawthorne D, Gasior M, Bhagwagar Z, Keswani S, AbuTarif M, Bertz R.

J Clin Pharmacol. 2015 Oct;55(10):1137-46. doi: 10.1002/jcph.528.

PMID: 25904041

 

Safety and efficacy of the HIV-1 attachment inhibitor prodrug BMS-663068 in treatment-experienced individuals: 24 week results of AI438011, a phase 2b, randomised controlled trial.

Lalezari JP, Latiff GH, Brinson C, Echevarría J, Treviño-Pérez S, Bogner JR, Thompson M, Fourie J, Sussmann Pena OA, Mendo Urbina FC, Martins M, Diaconescu IG, Stock DA, Joshi SR, Hanna GJ, Lataillade M; AI438011 study team..

Lancet HIV. 2015 Oct;2(10):e427-37. doi: 10.1016/S2352-3018(15)00177-0.

PMID: 26423650

 

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression.

Lenhart R, Kirov S, Desilva H, Cao J, Lei M, Johnston K, Peterson R, Schweizer L, Purandare A, Ross-Macdonald P, Fairchild C, Wong T, Wee S.

Mol Cancer Ther. 2015 Oct;14(10):2167-74. doi: 10.1158/1535-7163.MCT-15-0037.

PMID: 26253517

 

Establishing best practise in the application of expert review of mutagenicity under ICH M7.

Barber C, Amberg A, Custer L, Dobo KL, Glowienke S, Van Gompel J, Gutsell S, Harvey J, Honma M, Kenyon MO, Kruhlak N, Muster W, Stavitskaya L, Teasdale A, Vessey J, Wichard J.

Regul Toxicol Pharmacol. 2015 Oct;73(1):367-77. doi: 10.1016/j.yrtph.2015.07.018.

PMID: 26248005

 

Comparison of physiologic and pharmacologic parameters in Asian and mauritius cynomolgus macaques.

Kozlosky JC, Mysore J, Clark SP, Burr HN, Li J, Aranibar N, Vuppugalla R, West RC, Mangipudy RS, Graziano MJ.

Regul Toxicol Pharmacol. 2015 Oct;73(1):27-42. doi: 10.1016/j.yrtph.2015.06.008.

PMID: 26111605

 

PEGylated Biopharmaceuticals: Current Experience and Considerations for Nonclinical Development.

Ivens IA, Achanzar W, Baumann A, Brändli-Baiocco A, Cavagnaro J, Dempster M, Depelchin BO, Rovira AR, Dill-Morton L, Lane JH, Reipert BM, Salcedo T, Schweighardt B, Tsuruda LS, Turecek PL, Sims J.

Toxicol Pathol. 2015 Oct;43(7):959-83. doi: 10.1177/0192623315591171. Review.

PMID: 26239651

 

Investigation into process-induced de-aggregation of cohesive micronised API particles.

Hoffmann M, Wray PS, Gamble JF, Tobyn M.

Int J Pharm. 2015 Sep 30;493(1-2):341-6. doi: 10.1016/j.ijpharm.2015.07.073.

PMID: 26235919

 

The use of in situ near infrared imaging and Raman mapping to study the disproportionation of a drug HCl salt during dissolution.

Wray PS, Sinclair WE, Jones JW, Clarke GS, Both D.

Int J Pharm. 2015 Sep 30;493(1-2):198-207. doi: 10.1016/j.ijpharm.2015.07.045.

PMID: 26200745

 

Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor.

Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M.

J Chem Inf Model. 2015 Sep 28;55(9):1836-43. doi: 10.1021/acs.jcim.5b00388.

PMID: 26347990

 

Cost-Effectiveness of Cetuximab as First-line Treatment for Metastatic Colorectal Cancer in the United States.

Shankaran V, Ortendahl JD, Purdum AG, Bolinder B, Anene AM, Sun GH, Bentley TG.

Am J Clin Oncol. 2015 Sep 22. [Epub ahead of print]

PMID: 26398184

 

FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis.

Dahan R, Sega E, Engelhardt J, Selby M, Korman AJ, Ravetch JV.

Cancer Cell. 2015 Sep 14;28(3):285-95. doi: 10.1016/j.ccell.2015.08.004. Erratum in: Cancer Cell. 2015 Oct 12;28(4):543.

PMID: 26373277

 

Long-term changes in cardiovascular risk markers during administration of exenatide twice daily or glimepiride: results from the European exenatide study.

Simó R, Guerci B, Schernthaner G, Gallwitz B, Rosas-Guzmàn J, Dotta F, Festa A, Zhou M, Kiljański J.

Cardiovasc Diabetol. 2015 Sep 4;14:116. doi: 10.1186/s12933-015-0279-z.

PMID: 26338040

 

Utilizing Internal Standard Responses to Assess Risk on Reporting Bioanalytical Results from Hemolyzed Samples.

Fung EN, Aubry AF, Allentoff A, Ji QC.

AAPS J. 2015 Sep;17(5):1168-76. doi: 10.1208/s12248-015-9783-z.

PMID: 25975617

 

Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study.

Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, Soares HD, Kling MA, Mailman M, Arnold SE, Narayan VA, Lee VM, Shaw LM, Baker D, Wittenberg GM, Trojanowski JQ, Wang LS.

Alzheimers Dement (Amst). 2015 Sep 1;1(3):339-348.

PMID: 26693175

 

Assessment of drug-drug interactions between daclatasvir and methadone or buprenorphine-naloxone.

Garimella T, Wang R, Luo WL, Wastall P, Kandoussi H, DeMicco M, Bruce RD, Hwang C, Bertz R, Bifano M.

Antimicrob Agents Chemother. 2015 Sep;59(9):5503-10. doi: 10.1128/AAC.00478-15.

PMID: 26124175

 

Development of an automated PD-L1 immunohistochemistry (IHC) assay for non-small cell lung cancer.

Phillips T, Simmons P, Inzunza HD, Cogswell J, Novotny J Jr, Taylor C, Zhang X.

Appl Immunohistochem Mol Morphol. 2015 Sep;23(8):541-9. doi: 10.1097/PAI.0000000000000256.

PMID: 26317305

 

Bioanalysis of acetylcarnitine in cerebrospinal fluid by HILIC-mass spectrometry.

Holder BR, McNaney CA, Luchetti D, Schaeffer E, Drexler DM.

Biomed Chromatogr. 2015 Sep;29(9):1375-9. doi: 10.1002/bmc.3433.

PMID: 25712252

 

Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model.

Creasy A, Barker G, Yao Y, Carta G.

Biotechnol J. 2015 Sep;10(9):1400-11. doi: 10.1002/biot.201500089.

PMID: 26015091

 

Adaptation to high throughput batch chromatography enhances multivariate screening.

Barker GA, Calzada J, Herzer S, Rieble S.

Biotechnol J. 2015 Sep;10(9):1493-8. doi: 10.1002/biot.201400671.

PMID: 25914370

 

Efficient high-throughput biological process characterization: Definitive screening design with the ambr250 bioreactor system.

Tai M, Ly A, Leung I, Nayar G.

Biotechnol Prog. 2015 Sep-Oct;31(5):1388-95. doi: 10.1002/btpr.2142.

PMID: 26138048

 

The pharmacokinetics of peginterferon lambda-1a following single dose administration to subjects with impaired renal function.

Hruska MW, Adamczyk R, Colston E, Hesney M, Stonier M, Myler H, Bertz R.

Br J Clin Pharmacol. 2015 Sep;80(3):515-24. doi: 10.1111/bcp.12634.

PMID: 25807956

 

Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice.

Sanmamed MF, Rodriguez I, Schalper KA, Oñate C, Azpilikueta A, Rodriguez-Ruiz ME, Morales-Kastresana A, Labiano S, Pérez-Gracia JL, Martín-Algarra S, Alfaro C, Mazzolini G, Sarno F, Hidalgo M, Korman AJ, Jure-Kunkel M, Melero I.

Cancer Res. 2015 Sep 1;75(17):3466-78. doi: 10.1158/0008-5472.CAN-14-3510.

PMID: 26113085

 

Dapagliflozin lowers blood pressure in hypertensive and non-hypertensive patients with type 2 diabetes.

Sjöström CD, Johansson P, Ptaszynska A, List J, Johnsson E.

Diab Vasc Dis Res. 2015 Sep;12(5):352-8. doi: 10.1177/1479164115585298.

PMID: 26008804

 

Assessing Bladder Cancer Risk in Type 2 Diabetes Clinical Trials: the Dapagliflozin Drug Development Program as a 'Case Study'.

Ptaszynska A, Cohen SM, Messing EM, Reilly TP, Johnsson E, Johnsson K.

Diabetes Ther. 2015 Sep;6(3):357-75. doi: 10.1007/s13300-015-0128-9.

PMID: 26323372

 

Integrated risk assessment of suicidal ideation and behavior in drug development.

Muller PY, Dambach D, Gemzik B, Hartmann A, Ratcliffe S, Trendelenburg C, Urban L.

Drug Discov Today. 2015 Sep;20(9):1135-42. doi: 10.1016/j.drudis.2015.05.010. Review.

PMID: 26022402

 

Characterising and predicting bleeding in high-risk patients with an acute coronary syndrome.

Khan R, Lopes RD, Neely ML, Stevens SR, Harrington RA, Diaz R, Cools F, Jansky P, Montalescot G, Atar D, Lopez-Sendon J, Flather M, Liaw D, Wallentin L, Alexander JH, Goodman SG; Apixaban for Prevention of Acute Ischemic Safety Events (APPRAISE)-2 Steering Committee and Investigators..

Heart. 2015 Sep;101(18):1475-84. doi: 10.1136/heartjnl-2014-307346.

PMID: 26109589

 

Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MS.

Liu A, Lute J, Gu H, Wang B, Trouba KJ, Arnold ME, Aubry AF, Wang J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 1;1000:29-40. doi: 10.1016/j.jchromb.2015.07.006.

PMID: 26209768

 

Synthesis of 2-(14)C-iminothiolane and 2-(13)C,(15)N-iminothiolane (Traut's reagent).

Wallace M, Allentoff AJ, Brailsford J, Gong S, Bonacorsi S Jr, Rinaldi F.

J Labelled Comp Radiopharm. 2015 Sep-Oct;58(11-12):429-32. doi: 10.1002/jlcr.3345.

PMID: 26365707

 

Gordon L. Amidon: Very Sustained Drug Absorption.

Donovan MD, Polli JE, Langguth P, Tamai I, Vig B, Yu LX.

J Pharm Sci. 2015 Sep;104(9):2650-63. doi: 10.1002/jps.24523. No abstract available.

PMID: 26053319

 

Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.

Mosure KW, Knipe JO, Browning M, Arora V, Shu YZ, Phillip T, Mcphee F, Scola P, Balakrishnan A, Soars MG, Santone K, Sinz M.

J Pharm Sci. 2015 Sep;104(9):2813-23. doi: 10.1002/jps.24356.

PMID: 25631585

 

Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.

Lewis MA, Hunihan L, Watson J, Gentles RG, Hu S, Huang Y, Bronson J, Macor JE, Beno BR, Ferrante M, Hendricson A, Knox RJ, Molski TF, Kong Y, Cvijic ME, Rockwell KL, Weed MR, Cacace AM, Westphal RS, Alt A, Brown JM.

J Pharmacol Exp Ther. 2015 Sep;354(3):340-9. doi: 10.1124/jpet.115.224071.

PMID: 26109678

 

Renal studies in safety pharmacology and toxicology: A survey conducted in the top 15 pharmaceutical companies.

Benjamin A, Gallacher DJ, Greiter-Wilke A, Guillon JM, Kasai C, Ledieu D, Levesque P, Prelle K, Ratcliffe S, Sannajust F, Valentin JP.

J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:101-10. doi: 10.1016/j.vascn.2015.01.004.

PMID: 25637943

 

BCR-ABL1 mutation development during first-line treatment with dasatinib or imatinib for chronic myeloid leukemia in chronic phase.

Hughes TP, Saglio G, Quintás-Cardama A, Mauro MJ, Kim DW, Lipton JH, Bradley-Garelik MB, Ukropec J, Hochhaus A.

Leukemia. 2015 Sep;29(9):1832-8. doi: 10.1038/leu.2015.168.

PMID: 26118315

 

Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study.

Park JW, Chen M, Colombo M, Roberts LR, Schwartz M, Chen PJ, Kudo M, Johnson P, Wagner S, Orsini LS, Sherman M.

Liver Int. 2015 Sep;35(9):2155-66. doi: 10.1111/liv.12818.

PMID: 25752327

 

Use of demographic and pharmacy data to identify patients included within both the Clinical Practice Research Datalink (CPRD) and The Health Improvement Network (THIN).

Carbonari DM, Saine ME, Newcomb CW, Blak B, Roy JA, Haynes K, Wood J, Gallagher AM, Bhullar H, Cardillo S, Hennessy S, Strom BL, Lo Re V 3rd.

Pharmacoepidemiol Drug Saf. 2015 Sep;24(9):999-1003. doi: 10.1002/pds.3844.

PMID: 26213344

 

Prediction of pH dependent absorption using in vitro, in silico, and in vivo rat models: Early liability assessment during lead optimization.

Saxena A, Shah D, Padmanabhan S, Gautam SS, Chowan GS, Mandlekar S, Desikan S.

Eur J Pharm Sci. 2015 Aug 30;76:173-80. doi: 10.1016/j.ejps.2015.05.006.

PMID: 25960252

 

Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Findings From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial.

Avezum A, Lopes RD, Schulte PJ, Lanas F, Gersh BJ, Hanna M, Pais P, Erol C, Diaz R, Bahit MC, Bartunek J, De Caterina R, Goto S, Ruzyllo W, Zhu J, Granger CB, Alexander JH.

Circulation. 2015 Aug 25;132(8):624-32. doi: 10.1161/CIRCULATIONAHA.114.014807.

PMID: 26106009

 

Daclatasvir plus Sofosbuvir for HCV in Patients Coinfected with HIV-1.

Wyles DL, Ruane PJ, Sulkowski MS, Dieterich D, Luetkemeyer A, Morgan TR, Sherman KE, Dretler R, Fishbein D, Gathe JC Jr, Henn S, Hinestrosa F, Huynh C, McDonald C, Mills A, Overton ET, Ramgopal M, Rashbaum B, Ray G, Scarsella A, Yozviak J, McPhee F, Liu Z, Hughes E, Yin PD, Noviello S, Ackerman P; ALLY-2 Investigators..

N Engl J Med. 2015 Aug 20;373(8):714-25. doi: 10.1056/NEJMoa1503153.

PMID: 26196502

 

Apixaban Plus Mono Versus Dual Antiplatelet Therapy in Acute Coronary Syndromes: Insights From the APPRAISE-2 Trial.

Hess CN, James S, Lopes RD, Wojdyla DM, Neely ML, Liaw D, Hagstrom E, Bhatt DL, Husted S, Goodman SG, Lewis BS, Verheugt FW, De Caterina R, Ogawa H, Wallentin L, Alexander JH.

J Am Coll Cardiol. 2015 Aug 18;66(7):777-87. doi: 10.1016/j.jacc.2015.06.027.

PMID: 26271059

 

Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis.

Simon TA, Thompson A, Gandhi KK, Hochberg MC, Suissa S.

Arthritis Res Ther. 2015 Aug 15;17:212. doi: 10.1186/s13075-015-0728-9. Review. Erratum in: Arthritis Res Ther. 2016;18(1):100.

PMID: 26271620

 

Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma.

Lonial S, Dimopoulos M, Palumbo A, White D, Grosicki S, Spicka I, Walter-Croneck A, Moreau P, Mateos MV, Magen H, Belch A, Reece D, Beksac M, Spencer A, Oakervee H, Orlowski RZ, Taniwaki M, Röllig C, Einsele H, Wu KL, Singhal A, San-Miguel J, Matsumoto M, Katz J, Bleickardt E, Poulart V, Anderson KC, Richardson P; ELOQUENT-2 Investigators..

N Engl J Med. 2015 Aug 13;373(7):621-31. doi: 10.1056/NEJMoa1505654.

PMID: 26035255

 

Response to Letter Regarding Article, "Heart Failure, Saxagliptin and Diabetes Mellitus: Observations From the SAVOR-TIMI 53 Randomized Trial".

Scirica BM, Braunwald E, Raz I, Cavender MA, Morrow DA, Jarolim P, Udell JA, Mosenzon O, Im K, Umez-Eronini AA, Pollack PS, Hirshberg B, Frederich R, Lewis BS, McGuire DK, Davidson J, Steg G, Bhatt DL.

Circulation. 2015 Aug 11;132(6):e121-2. doi: 10.1161/CIRCULATIONAHA.115.015511. No abstract available.

PMID: 26260506

 

Targeting the tumor-stromal-immune cell axis.

Gururajan M, Josson S, Chung LW.

Oncoscience. 2015 Aug 11;2(9):743-4. No abstract available.

PMID: 26501076

 

Phase I safety data of lenalidomide, bortezomib, dexamethasone, and elotuzumab as induction therapy for newly diagnosed symptomatic multiple myeloma: SWOG S1211.

Usmani SZ, Sexton R, Ailawadhi S, Shah JJ, Valent J, Rosenzweig M, Lipe B, Zonder JA, Fredette S, Durie B, Hoering A, Bartlett B, Orlowski RZ.

Blood Cancer J. 2015 Aug 7;5:e334. doi: 10.1038/bcj.2015.62. No abstract available.

PMID: 26252787

 

Assessing Hyperspectral Image Content of Pharmaceutical Products Using the Herfindahl-Hirschman Index and Ripley's K-Functions.

Bobiak JP, McGeorge G.

Appl Spectrosc. 2015 Aug;69(8):955-65. doi: 10.1366/14-07650.

PMID: 26163504

 

Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors.

Degnan AP, Tora GO, Han Y, Rajamani R, Bertekap R, Krause R, Davis CD, Hu J, Morgan D, Taylor SJ, Krause K, Li YW, Mattson G, Cunningham MA, Taber MT, Lodge NJ, Bronson JJ, Gillman KW, Macor JE.

Bioorg Med Chem Lett. 2015 Aug 1;25(15):3039-43. doi: 10.1016/j.bmcl.2015.04.098.

PMID: 26048800

 

Relative Bioavailability of Apixaban Solution or Crushed Tablet Formulations Administered by Mouth or Nasogastric Tube in Healthy Subjects.

Song Y, Wang X, Perlstein I, Wang J, Badawy S, Frost C, LaCreta F.

Clin Ther. 2015 Aug;37(8):1703-12. doi: 10.1016/j.clinthera.2015.05.497.

PMID: 26188837

 

Costs and Resource Utilization Associated With Anemia and Rash in Chronic Hepatitis C Patients Treated With Direct-Acting Antiviral Agents in the United States.

Le TK, Macaulay D, Kalsekar A, Yuan Y, Sorg RA, Wei J, Wu EQ.

Clin Ther. 2015 Aug;37(8):1713-25.e3. doi: 10.1016/j.clinthera.2015.05.503.

PMID: 26111918

 

Dapagliflozin-induced weight loss affects 24-week glycated haemoglobin and blood pressure levels.

Sjöström CD, Hashemi M, Sugg J, Ptaszynska A, Johnsson E.

Diabetes Obes Metab. 2015 Aug;17(8):809-12. doi: 10.1111/dom.12500.

PMID: 25997813

 

Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment.

Chakraborty M, Fullerton AM, Semple K, Chea LS, Proctor WR, Bourdi M, Kleiner DE, Zeng X, Ryan PM, Dagur PK, Berkson JD, Reilly TP, Pohl LR.

Hepatology. 2015 Aug;62(2):546-57. doi: 10.1002/hep.27764.

PMID: 25712247

 

Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C.

Ahmad T, Yin P, Saffitz J, Pockros PJ, Lalezari J, Shiffman M, Freilich B, Zamparo J, Brown K, Dimitrova D, Kumar M, Manion D, Heath-Chiozzi M, Wolf R, Hughes E, Muir AJ, Hernandez AF.

Hepatology. 2015 Aug;62(2):409-16. doi: 10.1002/hep.27488.

PMID: 25251156

 

Assessment of the Efficacy and Safety of BMS-820836 in Patients With Treatment-Resistant Major Depression: Results From 2 Randomized, Double-Blind Studies.

Bhagwagar Z, Torbeyns A, Hennicken D, Zheng M, Dunlop BW, Mathew SJ, Khan A, Weisler R, Nelson C, Shelton R, Thase ME, Lane R.

J Clin Psychopharmacol. 2015 Aug;35(4):454-9. doi: 10.1097/JCP.0000000000000335.

PMID: 25961781

 

Increased risk of arterial thromboembolic events after Staphylococcus aureus bacteremia: A matched cohort study.

Mejer N, Gotland N, Uhre ML, Westh H, Schønheyder HC, Petersen A, Jensen AG, Larsen AR, Skov R, Benfield T; Danish Staphylococcal Bacteremia Study Group..

J Infect. 2015 Aug;71(2):167-78. doi: 10.1016/j.jinf.2015.03.010.

PMID: 25936743

 

Synthesis and characterization of tritium labeled N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-sulfamoylbenzamide.

Hong Y, Hynes J, Tian Y, Balasubramanian B, Bonacorsi S Jr.

J Labelled Comp Radiopharm. 2015 Aug;58(10):414-8. doi: 10.1002/jlcr.3320.

PMID: 26228905

 

Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.

Mangan PR, Su LJ, Jenny V, Tatum AL, Picarillo C, Skala S, Ditto N, Lin Z, Yang X, Cotter PZ, Shuster DJ, Song Y, Borowski V, Thomas RL, Heimrich EM, Devaux B, Das Gupta R, Carvajal I, McIntyre KW, Xie J, Zhao Q, Struthers M, Salter-Cid LM.

J Pharmacol Exp Ther. 2015 Aug;354(2):152-65. doi: 10.1124/jpet.115.224246.

PMID: 26015463

 

A randomized, placebo-controlled study of the NS5B inhibitor beclabuvir with peginterferon/ribavirin for HCV genotype 1.

Tatum H, Thuluvath PJ, Lawitz E, Martorell C, DeMicco M, Cohen S, Rustgi V, Ravendhran N, Ghalib R, Hanson J, Zamparo J, Zhao J, Cooney E, Treitel M, Hughes E.

J Viral Hepat. 2015 Aug;22(8):658-64. doi: 10.1111/jvh.12372.

PMID: 25496007

 

Evolving synergistic combinations of targeted immunotherapies to combat cancer.

Melero I, Berman DM, Aznar MA, Korman AJ, Pérez Gracia JL, Haanen J.

Nat Rev Cancer. 2015 Aug;15(8):457-72. doi: 10.1038/nrc3973. Review.

PMID: 26205340

 

Development of a Control Strategy for Benzene Impurity in HPMCAS-Stabilized Spray-Dried Dispersion Drug Products Using a Science-Based and Risk-Based Approach.

Yue H, Nicholson SJ, Young JD, Hsieh D, Ketner RJ, Hall RG, Sackett J, Banks EC, Castoro JA, Randazzo ME.

Pharm Res. 2015 Aug;32(8):2636-48. doi: 10.1007/s11095-015-1649-7.

PMID: 25724159

 

Role of Self-Association and Supersaturation in Oral Absorption of a Poorly Soluble Weakly Basic Drug.

Narang AS, Badawy S, Ye Q, Patel D, Vincent M, Raghavan K, Huang Y, Yamniuk A, Vig B, Crison J, Derbin G, Xu Y, Ramirez A, Galella M, Rinaldi FA.

Pharm Res. 2015 Aug;32(8):2579-94. doi: 10.1007/s11095-015-1645-y.

PMID: 25724158

 

Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine.

Wang C, Yamniuk A, Dai J, Chen S, Stetsko P, Ditto N, Zhang Y.

Pharm Res. 2015 Aug;32(8):2625-35. doi: 10.1007/s11095-015-1648-8.

PMID: 25670525

 

Cost-effectiveness Analysis Comparing Apixaban and Acenocoumarol in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation in Spain.

Barón Esquivias G, Escolar Albaladejo G, Zamorano JL, Betegón Nicolás L, Canal Fontcuberta C, de Salas-Cansado M, Rubio-Rodríguez D, Rubio-Terrés C.

Rev Esp Cardiol (Engl Ed). 2015 Aug;68(8):680-90. doi: 10.1016/j.rec.2014.08.010.

PMID: 25498373

 

Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS.

Sanmamed MF, Pastor F, Rodriguez A, Perez-Gracia JL, Rodriguez-Ruiz ME, Jure-Kunkel M, Melero I.

Semin Oncol. 2015 Aug;42(4):640-55. doi: 10.1053/j.seminoncol.2015.05.014. Review.

PMID: 26320067

 

Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.

Tirmenstein M, Horvath J, Graziano M, Mangipudy R, Dorr T, Colman K, Zinker B, Kirby M, Cheng PT, Patrone L, Kozlosky J, Reilly TP, Wang V, Janovitz E.

Toxicol Pathol. 2015 Aug;43(6):825-37. doi: 10.1177/0192623315581020.

PMID: 26085543

 

Checkpoint blockade for cancer therapy: revitalizing a suppressed immune system.

Pico de Coaña Y, Choudhury A, Kiessling R.

Trends Mol Med. 2015 Aug;21(8):482-91. doi: 10.1016/j.molmed.2015.05.005. Review.

PMID: 26091825

 

Prognostic factors for abatacept retention in patients who received at least one prior biologic agent: an interim analysis from the observational, prospective ACTION study.

Nüßlein HG, Alten R, Galeazzi M, Lorenz HM, Nurmohamed MT, Bensen WG, Burmester GR, Peter HH, Pavelka K, Chartier M, Poncet C, Rauch C, Le Bars M.

BMC Musculoskelet Disord. 2015 Jul 30;16:176. doi: 10.1186/s12891-015-0636-9.

PMID: 26228643

 

An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter.

Lucey BP, Gonzales C, Das U, Li J, Siemers ER, Slemmon JR, Bateman RJ, Huang Y, Fox GB, Claassen JA, Slats D, Verbeek MM, Tong G, Soares H, Savage MJ, Kennedy M, Forman M, Sjögren M, Margolin R, Chen X, Farlow MR, Dean RA, Waring JF.

Alzheimers Res Ther. 2015 Jul 29;7(1):53. doi: 10.1186/s13195-015-0136-z.

PMID: 26225140

 

CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation.

Roccaro AM, Mishima Y, Sacco A, Moschetta M, Tai YT, Shi J, Zhang Y, Reagan MR, Huynh D, Kawano Y, Sahin I, Chiarini M, Manier S, Cea M, Aljawai Y, Glavey S, Morgan E, Pan C, Michor F, Cardarelli P, Kuhne M, Ghobrial IM.

Cell Rep. 2015 Jul 28;12(4):622-35. doi: 10.1016/j.celrep.2015.06.059.

PMID: 26190113

 

Heterogeneous glycoform separation by process chromatography: I: Monomer purification and characterization.

Li Y, Xu X, Shupe A, Yang R, Bai K, Das T, Borys MC, Li ZJ.

J Chromatogr A. 2015 Jul 24;1404:51-9. doi: 10.1016/j.chroma.2015.05.054.

PMID: 26051082

 

Retrospective analysis of drug utilization, health care resource use, and costs associated with IFN therapy for adjuvant treatment of malignant melanoma.

Zhang Y, Le TK, Shaw JW, Kotapati S.

Clinicoecon Outcomes Res. 2015 Jul 21;7:397-407. doi: 10.2147/CEOR.S78704.

PMID: 26229494

 

Stroke and Bleeding Risk Associated With Antithrombotic Therapy for Patients With Nonvalvular Atrial Fibrillation in Clinical Practice.

An J, Niu F, Lang DT, Jazdzewski KP, Le PT, Rashid N, Meissner B, Mendes R, Dills DG, Aranda G, Bruno A.

J Am Heart Assoc. 2015 Jul 17;4(7). pii: e001921. doi: 10.1161/JAHA.115.001921.

PMID: 26187996

 

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.

Shaw SA, Balasubramanian B, Bonacorsi S, Cortes JC, Cao K, Chen BC, Dai J, Decicco C, Goswami A, Guo Z, Hanson R, Humphreys WG, Lam PY, Li W, Mathur A, Maxwell BD, Michaudel Q, Peng L, Pudzianowski A, Qiu F, Su S, Sun D, Tymiak AA, Vokits BP, Wang B, Wexler R, Wu DR, Zhang Y, Zhao R, Baran PS.

J Org Chem. 2015 Jul 17;80(14):7019-32. doi: 10.1021/acs.joc.5b00632. Erratum in: J Org Chem. 2015 Sep 18;80(18):9370.

PMID: 26151079

 

Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup.

Devasthale P, Wang W, Hernandez AS, Moore F, Renduchintala K, Sridhar R, Pelleymounter MA, Longhi D, Huang N, Flynn N, Azzara AV, Rohrbach K, Devenny J, Rooney S, Thomas M, Glick S, Godonis H, Harvey S, Cullen MJ, Zhang H, Caporuscio C, Stetsko P, Grubb M, Huang C, Zhang L, Freeden C, Li YX, Murphy BJ, Robl JA, Washburn WN.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2793-9. doi: 10.1016/j.bmcl.2015.05.008.

PMID: 26022839

 

9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors.

Zimmermann K, Sang X, Mastalerz HA, Johnson WL, Zhang G, Liu Q, Batt D, Lombardo LJ, Vyas D, Trainor GL, Tokarski JS, Lorenzi MV, You D, Gottardis MM, Lippy J, Khan J, Sack JS, Purandare AV.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2809-12. doi: 10.1016/j.bmcl.2015.04.101.

PMID: 25987372

 

Current complexity: a tool for assessing the complexity of organic molecules.

Li J, Eastgate MD.

Org Biomol Chem. 2015 Jul 14;13(26):7164-76. doi: 10.1039/c5ob00709g.

PMID: 25962620

 

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.

Wan H, Schroeder GM, Hart AC, Inghrim J, Grebinski J, Tokarski JS, Lorenzi MV, You D, Mcdevitt T, Penhallow B, Vuppugalla R, Zhang Y, Gu X, Iyer R, Lombardo LJ, Trainor GL, Ruepp S, Lippy J, Blat Y, Sack JS, Khan JA, Stefanski K, Sleczka B, Mathur A, Sun JH, Wong MK, Wu DR, Li P, Gupta A, Arunachalam PN, Pragalathan B, Narayanan S, K C N, Kuppusamy P, Purandare AV.

ACS Med Chem Lett. 2015 Jul 12;6(8):850-5. doi: 10.1021/acsmedchemlett.5b00226.

PMID: 26288683

 

Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors.

Hart AC, Schroeder GM, Wan H, Grebinski J, Inghrim J, Kempson J, Guo J, Pitts WJ, Tokarski JS, Sack JS, Khan JA, Lippy J, Lorenzi MV, You D, McDevitt T, Vuppugalla R, Zhang Y, Lombardo LJ, Trainor GL, Purandare AV.

ACS Med Chem Lett. 2015 Jul 10;6(8):845-9. doi: 10.1021/acsmedchemlett.5b00225.

PMID: 26288682

 

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.

Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, Waterhouse D, Ready N, Gainor J, Arén Frontera O, Havel L, Steins M, Garassino MC, Aerts JG, Domine M, Paz-Ares L, Reck M, Baudelet C, Harbison CT, Lestini B, Spigel DR.

N Engl J Med. 2015 Jul 9;373(2):123-35. doi: 10.1056/NEJMoa1504627.

PMID: 26028407

 

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.

Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P, Ferrucci PF, Hill A, Wagstaff J, Carlino MS, Haanen JB, Maio M, Marquez-Rodas I, McArthur GA, Ascierto PA, Long GV, Callahan MK, Postow MA, Grossmann K, Sznol M, Dreno B, Bastholt L, Yang A, Rollin LM, Horak C, Hodi FS, Wolchok JD.

N Engl J Med. 2015 Jul 2;373(1):23-34. doi: 10.1056/NEJMoa1504030.

PMID: 26027431

 

Food Effect in Humans: Predicting the Risk Through In Vitro Dissolution and In Vivo Pharmacokinetic Models.

Mathias N, Xu Y, Vig B, Kestur U, Saari A, Crison J, Desai D, Vanarase A, Hussain M.

AAPS J. 2015 Jul;17(4):988-98. doi: 10.1208/s12248-015-9759-z.

PMID: 25933598

 

Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay.

Ni YG, Yuan X, Newitt JA, Peterson JE, Gleason CR, Haulenbeek J, Santockyte R, Lafont V, Marsilio F, Neely RJ, DeSilva B, Piccoli SP.

AAPS J. 2015 Jul;17(4):976-87. doi: 10.1208/s12248-015-9762-4.

PMID: 25924887

 

High Sustained Virologic Response to Daclatasvir Plus Asunaprevir in Elderly and Cirrhotic Patients with Hepatitis C Virus Genotype 1b Without Baseline NS5A Polymorphisms.

McPhee F, Suzuki Y, Toyota J, Karino Y, Chayama K, Kawakami Y, Yu ML, Ahn SH, Ishikawa H, Bhore R, Zhou N, Hernandez D, Mendez P, Kumada H.

Adv Ther. 2015 Jul;32(7):637-49. doi: 10.1007/s12325-015-0221-5.

PMID: 26155891

 

Perspective: The Alzheimer's Disease Neuroimaging Initiative and the role and contributions of the Private Partner Scientific Board (PPSB).

Liu E, Luthman J, Cedarbaum JM, Schmidt ME, Cole PE, Hendrix J, Carrillo MC, Jones-Davis D, Tarver E, Novak G, De Santi S, Soares HD, Potter WZ, Siemers E, Schwarz AJ.

Alzheimers Dement. 2015 Jul;11(7):840-9. doi: 10.1016/j.jalz.2015.04.001. Review.

PMID: 26194317

 

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans.

Saykin AJ, Shen L, Yao X, Kim S, Nho K, Risacher SL, Ramanan VK, Foroud TM, Faber KM, Sarwar N, Munsie LM, Hu X, Soares HD, Potkin SG, Thompson PM, Kauwe JS, Kaddurah-Daouk R, Green RC, Toga AW, Weiner MW; Alzheimer's Disease Neuroimaging Initiative..

Alzheimers Dement. 2015 Jul;11(7):792-814. doi: 10.1016/j.jalz.2015.05.009. Review.

PMID: 26194313

 

The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans.

Kang JH, Korecka M, Figurski MJ, Toledo JB, Blennow K, Zetterberg H, Waligorska T, Brylska M, Fields L, Shah N, Soares H, Dean RA, Vanderstichele H, Petersen RC, Aisen PS, Saykin AJ, Weiner MW, Trojanowski JQ, Shaw LM; Alzheimer's Disease Neuroimaging Initiative..

Alzheimers Dement. 2015 Jul;11(7):772-91. doi: 10.1016/j.jalz.2015.05.003. Review.

PMID: 26194312

 

Warfarin and Aspirin Use for Stroke Prevention Among Patients With Atrial Fibrillation: The US National Health and Wellness Survey.

Goren A, Liu X, Gupta S, Simon TA, Phatak H.

Am J Ther. 2015 Jul-Aug;22(4):248-56. doi: 10.1097/MJT.0000000000000001.

PMID: 24326696

 

Pharmacokinetic interactions between BMS-626529, the active moiety of the HIV-1 attachment inhibitor prodrug BMS-663068, and ritonavir or ritonavir-boosted atazanavir in healthy subjects.

Zhu L, Hruska M, Hwang C, Shah V, Furlong M, Hanna GJ, Bertz R, Landry IS.

Antimicrob Agents Chemother. 2015 Jul;59(7):3816-22. doi: 10.1128/AAC.04914-14.

PMID: 25870057

 

 

Development and scale-up of the recovery and purification of a domain antibody Fc fusion protein-comparison of a two and three-step approach.

Herzer S, Bhangale A, Barker G, Chowdhary I, Conover M, O'Mara BW, Tsang L, Wang SY, Krystek SR Jr, Yao Y, Rieble S.

Biotechnol Bioeng. 2015 Jul;112(7):1417-28. doi: 10.1002/bit.25561.

PMID: 25683677

 

Bioequivalence, Food Effect, and Steady-State Assessment of Dapagliflozin/Metformin Extended-release Fixed-dose Combination Tablets Relative to Single-component Dapagliflozin and Metformin Extended-release Tablets in Healthy Subjects.

Chang M, Liu X, Cui D, Liang D, LaCreta F, Griffen SC, Lubin S, Quamina-Edghill D, Boulton DW.

Clin Ther. 2015 Jul 1;37(7):1517-28. doi: 10.1016/j.clinthera.2015.05.004.

PMID: 26048185

 

The cost-effectiveness of dapagliflozin versus sulfonylurea as an add-on to metformin in the treatment of Type 2 diabetes mellitus.

Charokopou M, McEwan P, Lister S, Callan L, Bergenheim K, Tolley K, Postema R, Townsend R, Roudaut M.

Diabet Med. 2015 Jul;32(7):890-8. doi: 10.1111/dme.12772.

PMID: 25817050

 

Treatment escalation options for patients with type 2 diabetes after failure of exenatide twice daily or glimepiride added to metformin: results from the prospective European Exenatide (EUREXA) study.

Schernthaner G, Rosas-Guzmán J, Dotta F, Guerci B, Simó R, Festa A, Kiljański J, Zhou M, Gallwitz B.

Diabetes Obes Metab. 2015 Jul;17(7):689-98. doi: 10.1111/dom.12471.

PMID: 25846577

 

Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.

Shen H, Liu T, Morse BL, Zhao Y, Zhang Y, Qiu X, Chen C, Lewin AC, Wang XT, Liu G, Christopher LJ, Marathe P, Lai Y.

Drug Metab Dispos. 2015 Jul;43(7):984-93. doi: 10.1124/dmd.114.062364.

PMID: 25904762

 

Comparison of thromboprophylaxis patterns in arthroplasty in public and private hospitals.

Cortada AP, Silva TG, Silva AC, Golmia RP, Guerra RL, Takemoto ML, Monteiro RD, Scheinberg MA.

Einstein (Sao Paulo). 2015 Jul-Sep;13(3):410-6. doi: 10.1590/S1679-45082015GS3057. English, Portuguese.

PMID: 26313439

 

 

Phase III randomized trial of second-line ixabepilone versus paclitaxel or doxorubicin in women with advanced endometrial cancer.

McMeekin S, Dizon D, Barter J, Scambia G, Manzyuk L, Lisyanskaya A, Oaknin A, Ringuette S, Mukhopadhyay P, Rosenberg J, Vergote I.

Gynecol Oncol. 2015 Jul;138(1):18-23. doi: 10.1016/j.ygyno.2015.04.026.

PMID: 25925990

 

Cytokines: The Good, the Bad, and the Deadly.

Ramani T, Auletta CS, Weinstock D, Mounho-Zamora B, Ryan PC, Salcedo TW, Bannish G.

Int J Toxicol. 2015 Jul-Aug;34(4):355-65. doi: 10.1177/1091581815584918.

PMID: 26015504

 

Hydromethylation of Unactivated Olefins.

Dao HT, Li C, Michaudel Q, Maxwell BD, Baran PS.

J Am Chem Soc. 2015 Jul 1;137(25):8046-9. doi: 10.1021/jacs.5b05144.

PMID: 26088401

 

D-α-tocopheryl polyethylene glycol 1000 succinate-containing vehicles provide no detectable chemoprotection from oxidative damage.

Baumgart BR, Van Vleet TR, Simic D, Salcedo TW, Lentz K, Donegan M, Davies MH, Bunch RT, Sanderson TP, Lange RW.

J Appl Toxicol. 2015 Jul;35(7):791-8. doi: 10.1002/jat.3072.

PMID: 25348750

 

Evaluation of the Dual-Chamber Pen Design for the Injection of Exenatide Once Weekly for the Treatment of Type 2 Diabetes.

LaRue S, Malloy J.

J Diabetes Sci Technol. 2015 Jul;9(4):815-21. doi: 10.1177/1932296815576186.

PMID: 25759181

 

Daclatasvir and asunaprevir plus peginterferon alfa and ribavirin in HCV genotype 1 or 4 non-responders.

Jensen D, Sherman KE, Hézode C, Pol S, Zeuzem S, de Ledinghen V, Tran A, Elkhashab M, Younes ZH, Kugelmas M, Mauss S, Everson G, Luketic V, Vierling J, Serfaty L, Brunetto M, Heo J, Bernstein D, McPhee F, Hennicken D, Mendez P, Hughes E, Noviello S; HALLMARK-QUAD Study Team..

J Hepatol. 2015 Jul;63(1):30-7. doi: 10.1016/j.jhep.2015.02.018.

PMID: 25703086

 

Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach.

Burrell RC, Turley WA, Bonacorsi SJ Jr.

J Labelled Comp Radiopharm. 2015 Jul;58(9):361-9. doi: 10.1002/jlcr.3312.

PMID: 26158758

 

Wetting effects versus ion pairs diffusivity: interactions of anionic surfactants with highly soluble cationic drugs and its impact on tablet dissolution.

Desai D, Wong B, Huang Y, Ye Q, Guo H, Huang M, Timmins P.

J Pharm Sci. 2015 Jul;104(7):2255-65. doi: 10.1002/jps.24478.

PMID: 26017286

 

Evaluating scale-up rules of a high-shear wet granulation process.

Tao J, Pandey P, Bindra DS, Gao JZ, Narang AS.

J Pharm Sci. 2015 Jul;104(7):2323-33. doi: 10.1002/jps.24504.

PMID: 26010137

 

Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients.

König K, Peifer M, Fassunke J, Ihle MA, Künstlinger H, Heydt C, Stamm K, Ueckeroth F, Vollbrecht C, Bos M, Gardizi M, Scheffler M, Nogova L, Leenders F, Albus K, Meder L, Becker K, Florin A, Rommerscheidt-Fuss U, Altmüller J, Kloth M, Nürnberg P, Henkel T, Bikár SE, Sos ML, Geese WJ, Strauss L, Ko YD, Gerigk U, Odenthal M, Zander T, Wolf J, Merkelbach-Bruse S, Buettner R, Heukamp LC.

J Thorac Oncol. 2015 Jul;10(7):1049-57. doi: 10.1097/JTO.0000000000000570.

PMID: 26102443

 

Efficacy and Safety of Nivolumab in Patients With BRAF V600 Mutant and BRAF Wild-Type Advanced Melanoma: A Pooled Analysis of 4 Clinical Trials.

Larkin J, Lao CD, Urba WJ, McDermott DF, Horak C, Jiang J, Wolchok JD.

JAMA Oncol. 2015 Jul;1(4):433-40. doi: 10.1001/jamaoncol.2015.1184.

PMID: 26181250

 

Optimization and Performance Assessment of the Chorion-Off [Dechorinated] Zebrafish Developmental Toxicity Assay.

Panzica-Kelly JM, Zhang CX, Augustine-Rauch KA.

Toxicol Sci. 2015 Jul;146(1):127-34. doi: 10.1093/toxsci/kfv076.

PMID: 25877614

 

Editorial: The emerging discipline of quantitative systems pharmacology.

Leil TA, Ermakov S.

Front Pharmacol. 2015 Jun 30;6:129. doi: 10.3389/fphar.2015.00129. No abstract available.

PMID: 26175687

 

Milestone Survival: A Potential Intermediate Endpoint for Immune Checkpoint Inhibitors.

Chen TT.

J Natl Cancer Inst. 2015 Jun 25;107(9). pii: djv156. doi: 10.1093/jnci/djv156.

PMID: 26113579

 

Simultaneous and stereospecific analysis of warfarin oxidative metabolism using 2D LC/Q-TOF.

Joseph S, Subramanian M, Khera S.

Bioanalysis. 2015 Jun 24:1-13. [Epub ahead of print]

PMID: 26105112

 

Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism.

Labiano S, Palazón A, Bolaños E, Azpilikueta A, Sánchez-Paulete AR, Morales-Kastresana A, Quetglas JI, Perez-Gracia JL, Gúrpide A, Rodriguez-Ruiz M, Aznar MA, Jure-Kunkel M, Berraondo P, Melero I.

Oncoimmunology. 2015 Jun 24;5(1):e1062967.

PMID: 26942078

 

 

Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression.

Liu D, Suchard SJ, Nadler SG, Ford ML.

PLoS One. 2015 Jun 22;10(6):e0130490. doi: 10.1371/journal.pone.0130490.

PMID: 26098894

 

Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer.

Gettinger SN, Horn L, Gandhi L, Spigel DR, Antonia SJ, Rizvi NA, Powderly JD, Heist RS, Carvajal RD, Jackman DM, Sequist LV, Smith DC, Leming P, Carbone DP, Pinder-Schenck MC, Topalian SL, Hodi FS, Sosman JA, Sznol M, McDermott DF, Pardoll DM, Sankar V, Ahlers CM, Salvati M, Wigginton JM, Hellmann MD, Kollia GD, Gupta AK, Brahmer JR.

J Clin Oncol. 2015 Jun 20;33(18):2004-12. doi: 10.1200/JCO.2014.58.3708.

PMID: 25897158

 

Survival, Durable Response, and Long-Term Safety in Patients With Previously Treated Advanced Renal Cell Carcinoma Receiving Nivolumab.

McDermott DF, Drake CG, Sznol M, Choueiri TK, Powderly JD, Smith DC, Brahmer JR, Carvajal RD, Hammers HJ, Puzanov I, Hodi FS, Kluger HM, Topalian SL, Pardoll DM, Wigginton JM, Kollia GD, Gupta A, McDonald D, Sankar V, Sosman JA, Atkins MB.

J Clin Oncol. 2015 Jun 20;33(18):2013-20. doi: 10.1200/JCO.2014.58.1041.

PMID: 25800770

 

 

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.

Balog A, Rampulla R, Martin GS, Krystek SR, Attar R, Dell-John J, DiMarco JD, Fairfax D, Gougoutas J, Holst CL, Nation A, Rizzo C, Rossiter LM, Schweizer L, Shan W, Spergel S, Spires T, Cornelius G, Gottardis M, Trainor G, Vite GD, Salvati ME.

ACS Med Chem Lett. 2015 Jun 19;6(8):908-12. doi: 10.1021/acsmedchemlett.5b00173.

PMID: 26288692

 

Ni-Catalyzed C-H Functionalization in the Formation of a Complex Heterocycle: Synthesis of the Potent JAK2 Inhibitor BMS-911543.

Fitzgerald MA, Soltani O, Wei C, Skliar D, Zheng B, Li J, Albrecht J, Schmidt M, Mahoney M, Fox RJ, Tran K, Zhu K, Eastgate MD.

J Org Chem. 2015 Jun 19;80(12):6001-11. doi: 10.1021/acs.joc.5b00572.

PMID: 25848821

 

Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257.

Ofotokun I, Na LH, Landovitz RJ, Ribaudo HJ, McComsey GA, Godfrey C, Aweeka F, Cohn SE, Sagar M, Kuritzkes DR, Brown TT, Patterson KB, Para MF, Leavitt RY, Villasis-Keever A, Baugh BP, Lennox JL, Currier JS; AIDS Clinical Trials Group (ACTG) A5257 Team..

Clin Infect Dis. 2015 Jun 15;60(12):1842-51. doi: 10.1093/cid/civ193.

PMID: 25767256

 

The genetic architecture of NAFLD among inbred strains of mice.

Hui ST, Parks BW, Org E, Norheim F, Che N, Pan C, Castellani LW, Charugundla S, Dirks DL, Psychogios N, Neuhaus I, Gerszten RE, Kirchgessner T, Gargalovic PS, Lusis AJ.

Elife. 2015 Jun 12;4:e05607. doi: 10.7554/eLife.05607.

PMID: 26067236

 

 

Attainment and characteristics of clinical remission according to the new ACR-EULAR criteria in abatacept-treated patients with early rheumatoid arthritis: new analyses from the Abatacept study to Gauge Remission and joint damage progression in methotrexate (MTX)-naive patients with Early Erosive rheumatoid arthritis (AGREE).

Smolen JS, Wollenhaupt J, Gomez-Reino JJ, Grassi W, Gaillez C, Poncet C, Le Bars M, Westhovens R.

Arthritis Res Ther. 2015 Jun 11;17:157. doi: 10.1186/s13075-015-0671-9.

PMID: 26063454

 

A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design.

Beno BR, Yeung KS, Bartberger MD, Pennington LD, Meanwell NA.

J Med Chem. 2015 Jun 11;58(11):4383-438. doi: 10.1021/jm501853m.

PMID: 25734370

 

Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma.

Schadendorf D, Hodi FS, Robert C, Weber JS, Margolin K, Hamid O, Patt D, Chen TT, Berman DM, Wolchok JD.

J Clin Oncol. 2015 Jun 10;33(17):1889-94. doi: 10.1200/JCO.2014.56.2736.

PMID: 25667295

 

PRINCE-1: safety and efficacy of atazanavir powder and ritonavir liquid in HIV-1-infected antiretroviral-naïve and -experienced infants and children aged ≥3 months to <6 years.

Strehlau R, Donati AP, Arce PM, Lissens J, Yang R, Biguenet S, Cambilargiu D, Hardy H, Correll T.

J Int AIDS Soc. 2015 Jun 10;18:19467. doi: 10.7448/IAS.18.1.19467.

PMID: 26066346

 

 

Scalable Synthesis of the Potent HIV Inhibitor BMS-986001 by Non-Enzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT).

Ortiz A, Benkovics T, Beutner GL, Shi Z, Bultman M, Nye J, Sfouggatakis C, Kronenthal DR.

Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7185-8. doi: 10.1002/anie.201502290.

PMID: 25925234

 

Ongoing HIV Transmission and the HIV Care Continuum in North Carolina.

Cope AB, Powers KA, Kuruc JD, Leone PA, Anderson JA, Ping LH, Kincer LP, Swanstrom R, Mobley VL, Foust E, Gay CL, Eron JJ, Cohen MS, Miller WC.

PLoS One. 2015 Jun 4;10(6):e0127950. doi: 10.1371/journal.pone.0127950

PMID: 26042804

 

Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus.

Graef JD, Newberry K, Newton A, Pieschl R, Shields E, Luan FN, Simmermacher J, Luchetti D, Schaeffer E, Li YW, Kiss L, Bristow LJ.

Brain Res. 2015 Jun 3;1609:31-9. doi: 10.1016/j.brainres.2015.03.019.

PMID: 25796435

 

The effect of BMS-582949, a P38 mitogen-activated protein kinase (P38 MAPK) inhibitor on arterial inflammation: a multicenter FDG-PET trial.

Emami H, Vucic E, Subramanian S, Abdelbaky A, Fayad ZA, Du S, Roth E, Ballantyne CM, Mohler ER, Farkouh ME, Kim J, Farmer M, Li L, Ehlgen A, Langenickel TH, Velasquez L, Hayes W, Tawakol A.

Atherosclerosis. 2015 Jun;240(2):490-6. doi: 10.1016/j.atherosclerosis.2015.03.039.

PMID: 25913664

 

Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis.

Tanaka H, Yang GX, Tomiyama T, Tsuneyama K, Zhang W, Leung PS, Coppel RL, Joh T, Nadler SG, Ansari AA, Bowlus C, Gershwin ME.

Clin Exp Immunol. 2015 Jun;180(3):371-82. doi: 10.1111/cei.12581.

PMID: 25581259

 

Effects of age and sex on the single-dose pharmacokinetics and pharmacodynamics of apixaban.

Frost CE, Song Y, Shenker A, Wang J, Barrett YC, Schuster A, Harris SI, LaCreta F.

Clin Pharmacokinet. 2015 Jun;54(6):651-62. doi: 10.1007/s40262-014-0228-0.

PMID: 25573421

 

Severe Acquired Idiopathic Thrombocytopenia in a Female Cynomolgus Macaque (Macaca fascicularis).

Parrula CM, Mysore J, Burr H, Freebern W, Neef N.

Comp Med. 2015 Jun;65(3):271-6.

PMID: 26141452

 

Efficacy and safety of saxagliptin in older participants in the SAVOR-TIMI 53 trial.

Leiter LA, Teoh H, Braunwald E, Mosenzon O, Cahn A, Kumar KM, Smahelova A, Hirshberg B, Stahre C, Frederich R, Bonnici F, Scirica BM, Bhatt DL, Raz I; SAVOR-TIMI 53 Steering Committee and Investigators..

Diabetes Care. 2015 Jun;38(6):1145-53. doi: 10.2337/dc14-2868.

PMID: 25758769

 

Metabolomics in the pharmaceutical industry.

Reily MD, Tymiak AA.

Drug Discov Today Technol. 2015 Jun;13:25-31. doi: 10.1016/j.ddtec.2015.03.001. Review.

PMID: 26190680

 

Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study.

Hézode C, Hirschfield GM, Ghesquiere W, Sievert W, Rodriguez-Torres M, Shafran SD, Thuluvath PJ, Tatum HA, Waked I, Esmat G, Lawitz EJ, Rustgi VK, Pol S, Weis N, Pockros PJ, Bourlière M, Serfaty L, Vierling JM, Fried MW, Weiland O, Brunetto MR, Everson GT, Zeuzem S, Kwo PY, Sulkowski M, Bräu N, Hernandez D, McPhee F, Wind-Rotolo M, Liu Z, Noviello S, Hughes EA, Yin PD, Schnittman S.

Gut. 2015 Jun;64(6):948-56. doi: 10.1136/gutjnl-2014-307498.

PMID: 25080450

 

Just-in-Time Compound Pooling Increases Primary Screening Capacity without Compromising Screening Quality.

Elkin LL, Harden DG, Saldanha S, Ferguson H, Cheney DL, Pieniazek SN, Maloney DP, Zewinski J, O'Connell J, Banks M.

J Biomol Screen. 2015 Jun;20(5):577-87. doi: 10.1177/1087057115572988.

PMID: 25722344

 

HPLC biogram analysis: a powerful tool used for hit confirmation in early drug discovery.

Leet JE, Belcastro JV, Dowling CJ, Nemeth GA, Weller HN.

J Biomol Screen. 2015 Jun;20(5):681-7. doi: 10.1177/1087057115569160.

PMID: 25681433

 

A UHPLC-MS/MS bioanalytical assay for the determination of BMS-911543, a JAK2 inhibitor, in human plasma.

Liu J, Yuan L, Liu G, Shen JX, Aubry AF, Arnold ME, Ji QC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jun 1;991:85-91. doi: 10.1016/j.jchromb.2015.04.013.

PMID: 25930207

 

Subvisible (2-100 μm) Particle Analysis During Biotherapeutic Drug Product Development: Part 1, Considerations and Strategy.

Narhi LO, Corvari V, Ripple DC, Afonina N, Cecchini I, Defelippis MR, Garidel P, Herre A, Koulov AV, Lubiniecki T, Mahler HC, Mangiagalli P, Nesta D, Perez-Ramirez B, Polozova A, Rossi M, Schmidt R, Simler R, Singh S, Spitznagel TM, Weiskopf A, Wuchner K.

J Pharm Sci. 2015 Jun;104(6):1899-908. doi: 10.1002/jps.24437. Review.

PMID: 25832583

 

Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341).

Yang MG, Dhar TG, Xiao Z, Xiao HY, Duan JJ, Jiang B, Galella MA, Cunningham M, Wang J, Habte S, Shuster D, McIntyre KW, Carman J, Holloway DA, Somerville JE, Nadler SG, Salter-Cid L, Barrish JC, Weinstein DS.

J Med Chem. 2015 May 28;58(10):4278-90. doi: 10.1021/acs.jmedchem.5b00257.

PMID: 25905990

 

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.

Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, Traynor JR, Gerritz SW, Alt A.

J Med Chem. 2015 May 28;58(10):4220-9. doi: 10.1021/acs.jmedchem.5b00007.

PMID: 25901762

 

Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.

Zhang Y, Seigal BA, Terrett NK, Talbott RL, Fargnoli J, Naglich JG, Chaudhry C, Posy SL, Vuppugalla R, Cornelius G, Lei M, Wang C, Zhang Y, Schmidt RJ, Wei DD, Miller MM, Allen MP, Li L, Carter PH, Vite GD, Borzilleri RM.

ACS Med Chem Lett. 2015 May 27;6(7):770-5. doi: 10.1021/acsmedchemlett.5b00091.

PMID: 26191364

 

Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression.

Edukulla R, Singh B, Jegga AG, Sontake V, Dillon SR, Madala SK.

J Biol Chem. 2015 May 22;290(21):13510-20. doi: 10.1074/jbc.M114.622126.

PMID: 25847241

 

Organic chemistry. Practical olefin hydroamination with nitroarenes.

Gui J, Pan CM, Jin Y, Qin T, Lo JC, Lee BJ, Spergel SH, Mertzman ME, Pitts WJ, La Cruz TE, Schmidt MA, Darvatkar N, Natarajan SR, Baran PS.

Science. 2015 May 22;348(6237):886-91. doi: 10.1126/science.aab0245.

PMID: 25999503

 

Clinical outcomes and management associated with major bleeding in patients with atrial fibrillation treated with apixaban or warfarin: insights from the ARISTOTLE trial.

Held C, Hylek EM, Alexander JH, Hanna M, Lopes RD, Wojdyla DM, Thomas L, Al-Khalidi H, Alings M, Xavier D, Ansell J, Goto S, Ruzyllo W, Rosenqvist M, Verheugt FW, Zhu J, Granger CB, Wallentin L.

Eur Heart J. 2015 May 21;36(20):1264-72. doi: 10.1093/eurheartj/ehu463.

PMID: 25499871

 

Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.

Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, Linette GP, Meyer N, Giguere JK, Agarwala SS, Shaheen M, Ernstoff MS, Minor D, Salama AK, Taylor M, Ott PA, Rollin LM, Horak C, Gagnier P, Wolchok JD, Hodi FS.

N Engl J Med. 2015 May 21;372(21):2006-17. doi: 10.1056/NEJMoa1414428.

PMID: 25891304

 

Safety and tolerability of exenatide once weekly in patients with type 2 diabetes: an integrated analysis of 4,328 patients.

MacConell L, Gurney K, Malloy J, Zhou M, Kolterman O.

Diabetes Metab Syndr Obes. 2015 May 18;8:241-53. doi: 10.2147/DMSO.S77290.

PMID: 26056482

 

Development of a Diastereoselective Phosphorylation of a Complex Nucleoside via Dynamic Kinetic Resolution.

Tran K, Beutner GL, Schmidt M, Janey J, Chen K, Rosso V, Eastgate MD.

J Org Chem. 2015 May 15;80(10):4994-5003. doi: 10.1021/acs.joc.5b00392.

PMID: 25840459

 

Comparison of glucose lowering effect of metformin and acarbose in type 2 diabetes mellitus: a meta-analysis.

Gu S, Shi J, Tang Z, Sawhney M, Hu H, Shi L, Fonseca V, Dong H.

PLoS One. 2015 May 11;10(5):e0126704. doi: 10.1371/journal.pone.0126704. Review.

PMID: 25961824

 

Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase.

Cox BD, Prosser AR, Sun Y, Li Z, Lee S, Huang MB, Bond VC, Snyder JP, Krystal M, Wilson LJ, Liotta DC.

ACS Med Chem Lett. 2015 May 6;6(7):753-7. doi: 10.1021/acsmedchemlett.5b00036.

PMID: 26191361

 

The prevalence and burden of systemic lupus erythematosus in a medicare population: retrospective analysis of medicare claims.

Garris C, Shah M, Farrelly E.

Cost Eff Resour Alloc. 2015 May 6;13:9. doi: 10.1186/s12962-015-0034-z.

PMID: 26019689

 

Patterns of response to aripiprazole, lithium, haloperidol, and placebo across factor scores of mania.

Ostacher MJ, Suppes T, Swann AC, Eudicone JM, Landsberg W, Baker RA, Carlson BX.

Int J Bipolar Disord. 2015 May 5;3:11. doi: 10.1186/s40345-015-0026-0.

PMID: 25945321

 

Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis.

Muir AJ, Poordad F, Lalezari J, Everson G, Dore GJ, Herring R, Sheikh A, Kwo P, Hézode C, Pockros PJ, Tran A, Yozviak J, Reau N, Ramji A, Stuart K, Thompson AJ, Vierling J, Freilich B, Cooper J, Ghesquiere W, Yang R, McPhee F, Hughes EA, Swenson ES, Yin PD.

JAMA. 2015 May 5;313(17):1736-44. doi: 10.1001/jama.2015.3868.

PMID: 25942724

 

Fixed-dose combination therapy with daclatasvir, asunaprevir, and beclabuvir for noncirrhotic patients with HCV genotype 1 infection.

Poordad F, Sievert W, Mollison L, Bennett M, Tse E, Bräu N, Levin J, Sepe T, Lee SS, Angus P, Conway B, Pol S, Boyer N, Bronowicki JP, Jacobson I, Muir AJ, Reddy KR, Tam E, Ortiz-Lasanta G, de Lédinghen V, Sulkowski M, Boparai N, McPhee F, Hughes E, Swenson ES, Yin PD; UNITY-1 Study Group..

JAMA. 2015 May 5;313(17):1728-35. doi: 10.1001/jama.2015.3860.

PMID: 25942723

 

Systematic Literature Review and Meta-Analysis of Renal Function in Human Immunodeficiency Virus (HIV)-Infected Patients Treated with Atazanavir (ATV)-Based Regimens.

Cure S, Bianic F, Espinas C, Hardy H, Rosenblatt L, Juday T.

PLoS One. 2015 May 4;10(5):e0124666. doi: 10.1371/journal.pone.0124666. Review.

PMID: 25938588

 

 

Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research.

O'Bryant SE, Gupta V, Henriksen K, Edwards M, Jeromin A, Lista S, Bazenet C, Soares H, Lovestone S, Hampel H, Montine T, Blennow K, Foroud T, Carrillo M, Graff-Radford N, Laske C, Breteler M, Shaw L, Trojanowski JQ, Schupf N, Rissman RA, Fagan AM, Oberoi P, Umek R, Weiner MW, Grammas P, Posner H, Martins R; STAR-B and BBBIG working groups..

Alzheimers Dement. 2015 May;11(5):549-60. doi: 10.1016/j.jalz.2014.08.099. Review.

PMID: 25282381

 

The 40-Hz auditory steady-state response: a selective biomarker for cortical NMDA function.

Sivarao DV.

Ann N Y Acad Sci. 2015 May;1344:27-36. doi: 10.1111/nyas.12739. Review.

PMID: 25809615

 

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.

Shan W, Balog A, Quesnelle C, Gill P, Han WC, Norris D, Mandal S, Thiruvenkadam R, Gona KB, Thiyagarajan K, Kandula S, McGlinchey K, Menard K, Wen ML, Rose A, White R, Guarino V, Shen DR, Cvijic ME, Ranasinghe A, Dai J, Zhang Y, Wu DR, Mathur A, Rampulla R, Trainor G, Hunt JT, Vite GD, Westhouse R, Lee FY, Gavai AV.

Bioorg Med Chem Lett. 2015 May 1;25(9):1905-9. doi: 10.1016/j.bmcl.2015.03.038.

PMID: 25857941

 

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.

Sivaprakasam P, Han X, Civiello RL, Jacutin-Porte S, Kish K, Pokross M, Lewis HA, Ahmed N, Szapiel N, Newitt JA, Baldwin ET, Xiao H, Krause CM, Park H, Nophsker M, Lippy JS, Burton CR, Langley DR, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2015 May 1;25(9):1856-63. doi: 10.1016/j.bmcl.2015.03.046.

PMID: 25845281

 

Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor.

Frost CE, Byon W, Song Y, Wang J, Schuster AE, Boyd RA, Zhang D, Yu Z, Dias C, Shenker A, LaCreta F.

Br J Clin Pharmacol. 2015 May;79(5):838-46. doi: 10.1111/bcp.12541.

PMID: 25377242

 

An open-label investigation into drug-drug interactions between multiple doses of daclatasvir and single-dose cyclosporine or tacrolimus in healthy subjects.

Bifano M, Adamczyk R, Hwang C, Kandoussi H, Marion A, Bertz RJ.

Clin Drug Investig. 2015 May;35(5):281-9. doi: 10.1007/s40261-015-0279-5.

PMID: 25896946

 

Integration of Physiologically-Based Pharmacokinetic Modeling into Early Clinical Development: An Investigation of the Pharmacokinetic Nonlinearity.

Zhou L, Gan J, Yoshitsugu H, Gu X, Lutz JD, Masson E, Humphreys WG.

CPT Pharmacometrics Syst Pharmacol. 2015 May;4(5):286-94. doi: 10.1002/psp4.35.

PMID: 26225254

 

RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications.

Suárez-Fariñas M, Ungar B, Correa da Rosa J, Ewald DA, Rozenblit M, Gonzalez J, Xu H, Zheng X, Peng X, Estrada YD, Dillon SR, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2015 May;135(5):1218-27. doi: 10.1016/j.jaci.2015.03.003.

PMID: 25840722

 

Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial.

Motzer RJ, Rini BI, McDermott DF, Redman BG, Kuzel TM, Harrison MR, Vaishampayan UN, Drabkin HA, George S, Logan TF, Margolin KA, Plimack ER, Lambert AM, Waxman IM, Hammers HJ.

J Clin Oncol. 2015 May 1;33(13):1430-7. doi: 10.1200/JCO.2014.59.0703.

PMID: 25452452

 

Randomized, blinded, placebo- and positive-controlled crossover study to determine the effect of multiple doses of apixaban on the QTc interval.

Frost C, Nepal S, Byon W, Moore K, Reeves RA, Boyd R, LaCreta F.

J Clin Pharmacol. 2015 May;55(5):549-55. doi: 10.1002/jcph.447.

PMID: 25501868

 

Dynamics of HCV genotype 4 resistance-associated variants during virologic escape with pIFN/RBV+daclatasvir: a case study using ultra deep pyrosequencing.

Bartolini B, Lionetti R, Giombini E, Sias C, Taibi C, Montalbano M, D'Offizi G, McPhee F, Hughes EA, Zhou N, Ippolito G, Garbuglia AR, Capobianchi MR.

J Clin Virol. 2015 May;66:38-43. doi: 10.1016/j.jcv.2015.02.001. Erratum in: J Clin Virol. 2015 Aug;69:252. Gianpiero, D'Offizi [corrected to D'Offizi, Gianpiero].

PMID: 25866334

 

A randomized trial of daclatasvir in combination with asunaprevir and beclabuvir in patients with chronic hepatitis C virus genotype 4 infection.

Hassanein T, Sims KD, Bennett M, Gitlin N, Lawitz E, Nguyen T, Webster L, Younossi Z, Schwartz H, Thuluvath PJ, Zhou H, Rege B, McPhee F, Zhou N, Wind-Rotolo M, Chung E, Griffies A, Grasela DM, Gardiner DF.

J Hepatol. 2015 May;62(5):1204-6. doi: 10.1016/j.jhep.2014.12.025. No abstract available.

PMID: 25559328

 

Characterization of submicron (0.1-1 μm) particles in therapeutic proteins by nanoparticle tracking analysis.

Vasudev R, Mathew S, Afonina N.

J Pharm Sci. 2015 May;104(5):1622-31. doi: 10.1002/jps.24411.

PMID: 25737284

 

Application of image-based particle size and shape characterization systems in the development of small molecule pharmaceuticals.

Gamble JF, Tobyn M, Hamey R.

J Pharm Sci. 2015 May;104(5):1563-74. doi: 10.1002/jps.24382. Review.

PMID: 25690940

 

Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys.

Shen H, Su H, Liu T, Yao M, Mintier G, Li L, Fancher RM, Iyer R, Marathe P, Lai Y, Rodrigues AD.

J Pharmacol Exp Ther. 2015 May;353(2):380-91. doi: 10.1124/jpet.114.221804.

PMID: 25740896

 

Comparison of costs and discharge outcomes for patients hospitalized for ischemic or hemorrhagic stroke with or without atrial fibrillation in the United States.

Pan X, Simon TA, Hamilton M, Kuznik A.

J Thromb Thrombolysis. 2015 May;39(4):508-15. doi: 10.1007/s11239-014-1144-8.

PMID: 25371108

 

Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial.

Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, Lebbé C, Ferraresi V, Smylie M, Weber JS, Maio M, Konto C, Hoos A, de Pril V, Gurunath RK, de Schaetzen G, Suciu S, Testori A.

Lancet Oncol. 2015 May;16(5):522-30. doi: 10.1016/S1470-2045(15)70122-1. Erratum in: Lancet Oncol. 2015 Jun;16(6):e262.

PMID: 25840693

 

The secondary drying and the fate of organic solvents for spray dried dispersion drug product.

Hsieh DS, Yue H, Nicholson SJ, Roberts D, Schild R, Gamble JF, Lindrud M.

Pharm Res. 2015 May;32(5):1804-16. doi: 10.1007/s11095-014-1577-y.

PMID: 25515491

 

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.

Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, Barrezueta N, Polson C, Wes P, Rangan VS, Cacace A, Albright CF, Meredith J Jr, Trojanowski JQ, Lee VM, Brunden KR, Ahlijanian M.

PLoS One. 2015 May 1;10(5):e0125614. doi: 10.1371/journal.pone.0125614.

PMID: 25933020

 

[Observational research is an important accompaniment to randomized and controlled clinical studies].

Li H, Wei L, Jia J, Niu J, Rao H, Zheng Z.

Zhonghua Gan Zang Bing Za Zhi. 2015 May;23(5):389-92. Chinese. No abstract available.

PMID: 26427073

 

Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice.

Thakker DR, Sankaranarayanan S, Weatherspoon MR, Harrison J, Pierdomenico M, Heisel JM, Thompson LA, Haskell R, Grace JE, Taylor SJ, Albright CF, Shafer LL.

J Neurosci. 2015 Apr 29;35(17):6931-6. doi: 10.1523/JNEUROSCI.2262-14.2015.

PMID: 25926467

 

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

Tokarski JS, Zupa-Fernandez A, Tredup JA, Pike K, Chang C, Xie D, Cheng L, Pedicord D, Muckelbauer J, Johnson SR, Wu S, Edavettal SC, Hong Y, Witmer MR, Elkin LL, Blat Y, Pitts WJ, Weinstein DS, Burke JR.

J Biol Chem. 2015 Apr 24;290(17):11061-74. doi: 10.1074/jbc.M114.619502.

PMID: 25762719

 

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier.

Lazear HM, Daniels BP, Pinto AK, Huang AC, Vick SC, Doyle SE, Gale M Jr, Klein RS, Diamond MS.

Sci Transl Med. 2015 Apr 22;7(284):284ra59. doi: 10.1126/scitranslmed.aaa4304. Erratum in: Sci Transl Med. 2015 May 27;7(289):289er5.

PMID: 25904743

 

High-resolution mass spectrometry-based background subtraction for identifying protein modifications in a complex biological system: detection of acetaminophen-bound microsomal proteins including argininosuccinate synthetase.

Zhang H, Gan J, Shu YZ, Humphreys WG.

Chem Res Toxicol. 2015 Apr 20;28(4):775-81. doi: 10.1021/tx500526s.

PMID: 25654186

 

Development and validation of a liquid chromatography tandem mass spectrometry assay for the quantitation of a protein therapeutic in cynomolgus monkey serum.

Zhao Y, Liu G, Angeles A, Hamuro LL, Trouba KJ, Wang B, Pillutla RC, DeSilva BS, Arnold ME, Shen JX.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:81-7. doi: 10.1016/j.jchromb.2015.02.007.

PMID: 25756208

 

"Center punch" and "whole spot" bioanalysis of apixaban in human dried blood spot samples by UHPLC-MS/MS.

Zheng N, Yuan L, Ji QC, Mangus H, Song Y, Frost C, Zeng J, Aubry AF, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:66-74. doi: 10.1016/j.jchromb.2015.02.023.

PMID: 25746754

 

Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' Moiety.

Hu Z, Wong PC, Gilligan PJ, Han W, Pabbisetty KB, Bozarth JM, Crain EJ, Harper T, Luettgen JM, Myers JE Jr, Ramamurthy V, Rossi KA, Sheriff S, Watson CA, Wei A, Zheng JJ, Seiffert DA, Wexler RR, Quan ML.

ACS Med Chem Lett. 2015 Apr 8;6(5):590-5. doi: 10.1021/acsmedchemlett.5b00066.

PMID: 26005539

 

The short-term cost-effectiveness of once-daily liraglutide versus once-weekly exenatide for the treatment of type 2 diabetes mellitus in the United States.

Wang B, Roth JA, Nguyen H, Felber E, Furnback W, Garrison LP.

PLoS One. 2015 Apr 7;10(4):e0121915. doi: 10.1371/journal.pone.0121915.

PMID: 25849542

 

Anticoagulant therapy and outcomes in patients with prior or acute heart failure and acute coronary syndromes: Insights from the APixaban for PRevention of Acute ISchemic Events 2 trial.

Cornel JH, Lopes RD, James S, Stevens SR, Neely ML, Liaw D, Miller J, Mohan P, Amerena J, Raev D, Huo Y, Urina-Triana M, Gallegos Cazorla A, Vinereanu D, Fridrich V, Harrington RA, Wallentin L, Alexander JH; APPRAISE-2 Study Group..

Am Heart J. 2015 Apr;169(4):531-8. doi: 10.1016/j.ahj.2014.12.022.

PMID: 25819860

 

The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.

Bi Y, Dzierba CD, Fink C, Garcia Y, Green M, Han J, Kwon S, Kumi G, Liang Z, Liu Y, Qiao Y, Zhang Y, Zipp G, Burford N, Ferrante M, Bertekap R, Lewis M, Cacace A, Westphal RS, Kimball D, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1443-7. doi: 10.1016/j.bmcl.2015.02.038.

PMID: 25754495

 

Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.

Pinto DJ, Smallheer JM, Corte JR, Austin EJ, Wang C, Fang T, Smith LM 2nd, Rossi KA, Rendina AR, Bozarth JM, Zhang G, Wei A, Ramamurthy V, Sheriff S, Myers JE Jr, Morin PE, Luettgen JM, Seiffert DA, Quan ML, Wexler RR.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1635-42. doi: 10.1016/j.bmcl.2015.01.028.

PMID: 25728130

 

Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.

Dzierba CD, Bi Y, Dasgupta B, Hartz RA, Ahuja V, Cianchetta G, Kumi G, Dong L, Aleem S, Fink C, Garcia Y, Green M, Han J, Kwon S, Qiao Y, Wang J, Zhang Y, Liu Y, Zipp G, Liang Z, Burford N, Ferrante M, Bertekap R, Lewis M, Cacace A, Grace J, Wilson A, Nouraldeen A, Westphal R, Kimball D, Carson K, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1448-52. doi: 10.1016/j.bmcl.2015.01.036.

PMID: 25690789

 

Comparison of Medical Costs of Patients With Atrial Fibrillation Unsuitable for Warfarin Treatment With Apixaban or Aspirin Based on AVERROES Trial.

Amin A, Deitelzweig S, Jing Y, Makenbaeva D, Wiederkehr D, Lin J, Graham J.

Clin Appl Thromb Hemost. 2015 Apr;21(3):235-40. doi: 10.1177/1076029613507335.

PMID: 24108232

 

Biomarkers in the pharmaceutical industry.

Laterza OF, Plump A, Ming JE, Richards S, Burczynski ME, Wagner JA, Patterson SD.

Clin Chem. 2015 Apr;61(4):579-83. doi: 10.1373/clinchem.2014.225284. No abstract available.

PMID: 25376580

 

Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes and moderate or severe renal impairment: observations from the SAVOR-TIMI 53 Trial.

Udell JA, Bhatt DL, Braunwald E, Cavender MA, Mosenzon O, Steg PG, Davidson JA, Nicolau JC, Corbalan R, Hirshberg B, Frederich R, Im K, Umez-Eronini AA, He P, McGuire DK, Leiter LA, Raz I, Scirica BM; SAVOR-TIMI 53 Steering Committee and Investigators..

Diabetes Care. 2015 Apr;38(4):696-705. doi: 10.2337/dc14-1850.

PMID: 25552421

 

Contribution of metabolites to P450 inhibition-based drug-drug interactions: scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group.

Yu H, Balani SK, Chen W, Cui D, He L, Humphreys WG, Mao J, Lai WG, Lee AJ, Lim HK, MacLauchlin C, Prakash C, Surapaneni S, Tse S, Upthagrove A, Walsky RL, Wen B, Zeng Z.

Drug Metab Dispos. 2015 Apr;43(4):620-30. doi: 10.1124/dmd.114.059345.

PMID: 25655830

 

Identification of glutathione conjugates of acetylene-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5.

Zhuo X, Huang XS, Degnan AP, Snyder LB, Yang F, Huang H, Shu YZ, Johnson BM.

Drug Metab Dispos. 2015 Apr;43(4):578-89. doi: 10.1124/dmd.114.061879.

PMID: 25633841

 

Clinical outcomes of patients with diabetes and atrial fibrillation treated with apixaban: results from the ARISTOTLE trial.

Ezekowitz JA, Lewis BS, Lopes RD, Wojdyla DM, McMurray JJ, Hanna M, Atar D, Cecilia Bahit M, Keltai M, Lopez-Sendon JL, Pais P, Ruzyllo W, Wallentin L, Granger CB, Alexander JH.

Eur Heart J Cardiovasc Pharmacother. 2015 Apr;1(2):86-94. doi: 10.1093/ehjcvp/pvu024.

PMID: 27533976

 

Strategies for improving sensitivity and selectivity for the quantitation of biotherapeutics in biological matrix using LC-MS/MS.

Shen JX, Liu G, Zhao Y.

Expert Rev Proteomics. 2015 Apr;12(2):125-31. doi: 10.1586/14789450.2015.1024225. Review.

PMID: 25776016

 

Five-year survival rates for treatment-naive patients with advanced melanoma who received ipilimumab plus dacarbazine in a phase III trial.

Maio M, Grob JJ, Aamdal S, Bondarenko I, Robert C, Thomas L, Garbe C, Chiarion-Sileni V, Testori A, Chen TT, Tschaika M, Wolchok JD.

J Clin Oncol. 2015 Apr 1;33(10):1191-6. doi: 10.1200/JCO.2014.56.6018.

PMID: 25713437

 

Development and characterization of a free therapeutic ligand binding assay with assistance from kinetics modeling.

Williams L, Sank M, Chimalakonda A, Ni Y, Saewert M, DeSilva B, Pillutla R.

J Immunol Methods. 2015 Apr;419:18-24. doi: 10.1016/j.jim.2015.02.009.

PMID: 25728474

 

Modeling the oxidation of methionine residues by peroxides in proteins.

Chennamsetty N, Quan Y, Nashine V, Sadineni V, Lyngberg O, Krystek S.

J Pharm Sci. 2015 Apr;104(4):1246-55. doi: 10.1002/jps.24340.

PMID: 25641333

 

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial.

Weber JS, D'Angelo SP, Minor D, Hodi FS, Gutzmer R, Neyns B, Hoeller C, Khushalani NI, Miller WH Jr, Lao CD, Linette GP, Thomas L, Lorigan P, Grossmann KF, Hassel JC, Maio M, Sznol M, Ascierto PA, Mohr P, Chmielowski B, Bryce A, Svane IM, Grob JJ, Krackhardt AM, Horak C, Lambert A, Yang AS, Larkin J.

Lancet Oncol. 2015 Apr;16(4):375-84. doi: 10.1016/S1470-2045(15)70076-8.

PMID: 25795410

 

Haematological malignancies: at the forefront of immunotherapeutic innovation.

Bachireddy P, Burkhardt UE, Rajasagi M, Wu CJ.

Nat Rev Cancer. 2015 Apr;15(4):201-15. doi: 10.1038/nrc3907. Review.

PMID: 25786696

 

Tasimelteon: a selective and unique receptor binding profile.

Lavedan C, Forsberg M, Gentile AJ.

Neuropharmacology. 2015 Apr;91:142-7. doi: 10.1016/j.neuropharm.2014.12.004.

PMID: 25534555

 

The development of immunomodulatory monoclonal antibodies as a new therapeutic modality for cancer: the Bristol-Myers Squibb experience.

Berman D, Korman A, Peck R, Feltquate D, Lonberg N, Canetta R.

Pharmacol Ther. 2015 Apr;148:132-53. doi: 10.1016/j.pharmthera.2014.11.017. Review.

PMID: 25476108

 

Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models.

Holenarsipur VK, Gaud N, Sinha J, Sivaprasad S, Bhutani P, Subramanian M, Singh SP, Arla R, Paruchury S, Sharma T, Marathe P, Mandlekar S.

Biopharm Drug Dispos. 2015 Mar 31. doi: 10.1002/bdd.1950. [Epub ahead of print]

PMID: 25832562

 

Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes.

Friborg J, Ross-Macdonald P, Cao J, Willard R, Lin B, Eggers B, McPhee F.

PLoS One. 2015 Mar 31;10(3):e0121734. doi: 10.1371/journal.pone.0121734.

PMID: 25826356

 

Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening.

Cheney DL, Bozarth JM, Metzler WJ, Morin PE, Mueller L, Newitt JA, Nirschl AH, Rendina AR, Tamura JK, Wei A, Wen X, Wurtz NR, Seiffert DA, Wexler RR, Priestley ES.

J Med Chem. 2015 Mar 26;58(6):2799-808. doi: 10.1021/jm501982k.

PMID: 25764119

 

Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma.

Jiang H, Kandoussi H, Zeng J, Wang J, Demers R, Eley T, He B, Burrell R, Easter J, Kadiyala P, Pursley J, Cojocaru L, Baker C, Ryan J, Aubry AF, Arnold ME.

J Pharm Biomed Anal. 2015 Mar 25;107:409-18. doi: 10.1016/j.jpba.2015.01.027.

PMID: 25676854

 

Sensitive and accurate liquid chromatography-tandem mass spectrometry methods for quantitative determination of a novel hepatitis C NS5B inhibitor BMS-791325 and its active metabolite in human plasma and urine.

Jiang H, Demers R, Kandoussi H, Burrell R, Eley T, Kadiyala P, Cojocaru L, Baker C, Ryan J, Aubry AF, Arnold ME, Zeng J.

J Pharm Biomed Anal. 2015 Mar 25;107:17-23. doi: 10.1016/j.jpba.2014.12.011.

PMID: 25562845

 

Trace level liquid chromatography tandem mass spectrometry quantification of the mutagenic impurity 2-hydroxypyridine N-oxide as its dansyl derivative.

Ding W, Huang Y, Miller SA, Bolgar MS.

J Chromatogr A. 2015 Mar 20;1386:47-52. doi: 10.1016/j.chroma.2015.01.079.

PMID: 25683628

 

Comparative value of four measures of retention in expert care in predicting clinical outcomes and health care utilization in HIV patients.

Reveles KR, Juday TR, Labreche MJ, Mortensen EM, Koeller JM, Seekins D, Oramasionwu CU, Bollinger M, Copeland LA, Jones X, Frei CR.

PLoS One. 2015 Mar 20;10(3):e0120953. doi: 10.1371/journal.pone.0120953.

PMID: 25794182

 

Selective reaction monitoring of negative electrospray ionization acetate adduct ions for the bioanalysis of dapagliflozin in clinical studies.

Ji QC, Xu X, Ma E, Liu J, Basdeo S, Liu G, Mylott W, Boulton DW, Shen JX, Stouffer B, Aubry AF, Arnold ME.

Anal Chem. 2015 Mar 17;87(6):3247-54. doi: 10.1021/ac5037523.

PMID: 25671589

 

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Zhang H, Ding CZ, Lai Z, Chen SS, Devasthale P, Herpin T, Morton G, Qu F, Ryono D, Smirk R, Wang W, Wu S, Ye XX, Li YX, Apedo A, Farrelly D, Wang T, Gu L, Morgan N, Flynn N, Chu C, Kunselman L, Lippy J, Locke K, O'Malley K, Harrity T, Cap M, Zhang L, Hosagrahara V, Kadiyala P, Xu C, Doweyko AM, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1196-205. doi: 10.1016/j.bmcl.2015.01.066.

PMID: 25686852

 

Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers.

Modugno M, Banfi P, Gasparri F, Borzilleri R, Carter P, Cornelius L, Gottardis M, Lee V, Mapelli C, Naglich JG, Tebben A, Vite G, Pastori W, Albanese C, Corti E, Ballinari D, Galvani A.

Exp Cell Res. 2015 Mar 15;332(2):267-77. doi: 10.1016/j.yexcr.2014.11.022.

PMID: 25486070

 

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

Gavai AV, Quesnelle C, Norris D, Han WC, Gill P, Shan W, Balog A, Chen K, Tebben A, Rampulla R, Wu DR, Zhang Y, Mathur A, White R, Rose A, Wang H, Yang Z, Ranasinghe A, D'Arienzo C, Guarino V, Xiao L, Su C, Everlof G, Arora V, Shen DR, Cvijic ME, Menard K, Wen ML, Meredith J, Trainor G, Lombardo LJ, Olson R, Baran PS, Hunt JT, Vite GD, Fischer BS, Westhouse RA, Lee FY.

ACS Med Chem Lett. 2015 Mar 11;6(5):523-7. doi: 10.1021/acsmedchemlett.5b00001.

PMID: 26005526

 

 Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5.

Carter PH, Brown GD, Cherney RJ, Batt DG, Chen J, Clark CM, Cvijic ME, Duncia JV, Ko SS, Mandlekar S, Mo R, Nelson DJ, Pang J, Rose AV, Santella JB 3rd, Tebben AJ, Traeger SC, Xu S, Zhao Q, Barrish JC.

ACS Med Chem Lett. 2015 Mar 4;6(4):439-44. doi: 10.1021/ml500505q.

PMID: 25893046

 

Comparison of "Word" vs. "Picture" Version of the Free and Cued Selective Reminding Test (FCSRT) in Older Adults.

Zimmerman ME, Katz MJ, Wang C, Burns LC, Berman RM, Derby CA, L'Italien G, Budd D, Lipton RB.

Alzheimers Dement (Amst). 2015 Mar 1;1(1):94-100.

PMID: 25870860

 

Outcomes related to postsurgical opioids--reply.

Minkowitz HS, Gruschkus SK, Shah M, Raju A.

Am J Health Syst Pharm. 2015 Mar 1;72(5):346. doi: 10.2146/ajhp140764. No abstract available.

PMID: 25694406

 

Maintenance of remission following 2 years of standard treatment then dose reduction with abatacept in patients with early rheumatoid arthritis and poor prognosis.

Westhovens R, Robles M, Ximenes AC, Wollenhaupt J, Durez P, Gomez-Reino J, Grassi W, Haraoui B, Shergy W, Park SH, Genant H, Peterfy C, Becker JC, Murthy B.

Ann Rheum Dis. 2015 Mar;74(3):564-8. doi: 10.1136/annrheumdis-2014-206149.

PMID: 25550337

 

Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin.

Rosenstock J, Hansen L, Zee P, Li Y, Cook W, Hirshberg B, Iqbal N.

Diabetes Care. 2015 Mar;38(3):376-83. doi: 10.2337/dc14-1142.

PMID: 25352655

 

Exploring the potential of the SGLT2 inhibitor dapagliflozin in type 1 diabetes: a randomized, double-blind, placebo-controlled pilot study.

Henry RR, Rosenstock J, Edelman S, Mudaliar S, Chalamandaris AG, Kasichayanula S, Bogle A, Iqbal N, List J, Griffen SC.

Diabetes Care. 2015 Mar;38(3):412-9. doi: 10.2337/dc13-2955.

PMID: 25271207

 

Falk Herbert Weih (1959-2014).

Ryseck RP, Caamaño J.

Eur J Immunol. 2015 Mar;45(3):650-1. doi: 10.1002/eji.201570035. No abstract available.

PMID: 25758036

 

Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS.

Onorato JM, Chu CH, Ma Z, Kopcho LM, Chao HJ, Lawrence RM, Cheng D.

J Lipid Res. 2015 Mar;56(3):747-53. doi: 10.1194/jlr.D055020.

PMID: 25598079

 

Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.

Wagshal D, Sankaranarayanan S, Guss V, Hall T, Berisha F, Lobach I, Karydas A, Voltarelli L, Scherling C, Heuer H, Tartaglia MC, Miller Z, Coppola G, Ahlijanian M, Soares H, Kramer JH, Rabinovici GD, Rosen HJ, Miller BL, Meredith J, Boxer AL.

J Neurol Neurosurg Psychiatry. 2015 Mar;86(3):244-50. doi: 10.1136/jnnp-2014-308004.

PMID: 24899730

 

Real-time assessment of granule densification in high shear wet granulation and application to scale-up of a placebo and a brivanib alaninate formulation.

Narang AS, Sheverev VA, Stepaniuk V, Badawy S, Stevens T, Macias K, Wolf A, Pandey P, Bindra D, Varia S.

J Pharm Sci. 2015 Mar;104(3):1019-34. doi: 10.1002/jps.24233.

PMID: 25470221

 

Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial.

Rizvi NA, Mazières J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, Horn L, Lena H, Minenza E, Mennecier B, Otterson GA, Campos LT, Gandara DR, Levy BP, Nair SG, Zalcman G, Wolf J, Souquet PJ, Baldini E, Cappuzzo F, Chouaid C, Dowlati A, Sanborn R, Lopez-Chavez A, Grohe C, Huber RM, Harbison CT, Baudelet C, Lestini BJ, Ramalingam SS.

Lancet Oncol. 2015 Mar;16(3):257-65. doi: 10.1016/S1470-2045(15)70054-9.

PMID: 25704439

 

Five-year efficacy and safety data of exenatide once weekly: long-term results from the DURATION-1 randomized clinical trial.

Wysham CH, MacConell LA, Maggs DG, Zhou M, Griffin PS, Trautmann ME.

Mayo Clin Proc. 2015 Mar;90(3):356-65. doi: 10.1016/j.mayocp.2015.01.008.

PMID: 25744115

 

Impact of micromeritic properties of an active pharmaceutical ingredient on its compaction behavior.

Bindra DS, Desikan S.

Pharm Dev Technol. 2015 Mar;20(2):129-38. doi: 10.3109/10837450.2013.852569.

PMID: 24219704

 

Status of oral anticoagulant treatment in patients with nonvalvular atrial fibrillation in Spain. REACT-AF Study.

de Andrés-Nogales F, Oyagüez I, Betegón-Nicolás L, Canal-Fontcuberta C, Soto-Álvarez J.

Rev Clin Esp. 2015 Mar;215(2):73-82. doi: 10.1016/j.rce.2014.08.008. English, Spanish.

PMID: 25288530

 

What is your diagnosis? Urine from a cynomolgus monkey.

Parrula MC, Pandya D.

Vet Clin Pathol. 2015 Mar;44(1):169-70. doi: 10.1111/vcp.12211. No abstract available.

PMID: 25361214

 

Developing Adnectins that target SRC co-activator binding to PXR: a structural approach toward understanding promiscuity of PXR.

Khan JA, Camac DM, Low S, Tebben AJ, Wensel DL, Wright MC, Su J, Jenny V, Gupta RD, Ruzanov M, Russo KA, Bell A, An Y, Bryson JW, Gao M, Gambhire P, Baldwin ET, Gardner D, Cavallaro CL, Duncia JV, Hynes J Jr.

J Mol Biol. 2015 Feb 27;427(4):924-42. doi: 10.1016/j.jmb.2014.12.022.

PMID: 25579995

 

Provider beliefs about diabetes treatment have little impact on glycemic control of their patients with diabetes.

LeBlanc ES, Rosales AG, Kachroo S, Mukherjee J, Funk KL, Schneider JL, Nichols GA.

BMJ Open Diabetes Res Care. 2015 Feb 24;3(1):e000062. doi: 10.1136/bmjdrc-2014-000062.

PMID: 25741443

 

Pyridine and pyridinone-based factor XIa inhibitors.

Corte JR, Fang T, Hangeland JJ, Friends TJ, Rendina AR, Luettgen JM, Bozarth JM, Barbera FA, Rossi KA, Wei A, Ramamurthy V, Morin PE, Seiffert DA, Wexler RR, Quan ML.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):925-30. doi: 10.1016/j.bmcl.2014.12.050.

PMID: 25592713

 

Safety, correlative markers, and clinical results of adjuvant nivolumab in combination with vaccine in resected high-risk metastatic melanoma.

Gibney GT, Kudchadkar RR, DeConti RC, Thebeau MS, Czupryn MP, Tetteh L, Eysmans C, Richards A, Schell MJ, Fisher KJ, Horak CE, Inzunza HD, Yu B, Martinez AJ, Younos I, Weber JS.

Clin Cancer Res. 2015 Feb 15;21(4):712-20. doi: 10.1158/1078-0432.CCR-14-2468.

PMID: 25524312

 

Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.

Perez HL, Chaudhry C, Emanuel SL, Fanslau C, Fargnoli J, Gan J, Kim KS, Lei M, Naglich JG, Traeger SC, Vuppugalla R, Wei DD, Vite GD, Talbott RL, Borzilleri RM.

J Med Chem. 2015 Feb 12;58(3):1556-62. doi: 10.1021/jm501482t.

PMID: 25584393

 

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.

Kenny HA, Lal-Nag M, White EA, Shen M, Chiang CY, Mitra AK, Zhang Y, Curtis M, Schryver EM, Bettis S, Jadhav A, Boxer MB, Li Z, Ferrer M, Lengyel E.

Nat Commun. 2015 Feb 5;6:6220. doi: 10.1038/ncomms7220. Erratum in: Nat Commun. 2016;7:10649.

PMID: 25653139

 

Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes.

Blonde L, Pencek R, MacConell L.

Cardiovasc Diabetol. 2015 Feb 3;14:12. doi: 10.1186/s12933-014-0171-2.

PMID: 25645567

 

Genetic architecture of insulin resistance in the mouse.

Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis AJ.

Cell Metab. 2015 Feb 3;21(2):334-46. doi: 10.1016/j.cmet.2015.01.002.

PMID: 25651185

 

Development of a material sparing bulk density test comparable to a standard USP method for use in early development of API's.

Hughes H, Leane MM, Tobyn M, Gamble JF, Munoz S, Musembi P.

AAPS PharmSciTech. 2015 Feb;16(1):165-70. doi: 10.1208/s12249-014-0215-7.

PMID: 25233802

 

Immune-priming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy.

Shahabi V, Postow MA, Tuck D, Wolchok JD.

Am J Clin Oncol. 2015 Feb;38(1):90-7. doi: 10.1097/COC.0b013e3182868ec8. Review.

PMID: 25616204

 

A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.

Ross TM, Battista K, Bignan GC, Brenneman DE, Connolly PJ, Liu J, Middleton SA, Orsini M, Reitz AB, Rosenthal DI, Scott MK, Vaidya AH.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):602-6. doi: 10.1016/j.bmcl.2014.12.015.

PMID: 25556095

 

Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.

Naidu BN, Sorenson ME, Patel M, Ueda Y, Banville J, Beaulieu F, Bollini S, Dicker IB, Higley H, Lin Z, Pajor L, Parker DD, Terry BJ, Zheng M, Martel A, Meanwell NA, Krystal M, Walker MA.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):717-20. doi: 10.1016/j.bmcl.2014.11.060.

PMID: 25529736

 

Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

Hannani D, Vétizou M, Enot D, Rusakiewicz S, Chaput N, Klatzmann D, Desbois M, Jacquelot N, Vimond N, Chouaib S, Mateus C, Allison JP, Ribas A, Wolchok JD, Yuan J, Wong P, Postow M, Mackiewicz A, Mackiewicz J, Schadendorff D, Jaeger D, Zörnig I, Hassel J, Korman AJ, Bahjat K, Maio M, Calabro L, Teng MW, Smyth MJ, Eggermont A, Robert C, Kroemer G, Zitvogel L.

Cell Res. 2015 Feb;25(2):208-24. doi: 10.1038/cr.2015.3. Erratum in: Cell Res. 2015 Mar;25(3):399-400. Zörnig, Inka [added]; Hassel, Jessica [added].

PMID: 25582080

 

Ixabepilone alone or with cetuximab as first-line treatment for advanced/metastatic triple-negative breast cancer.

Trédan O, Campone M, Jassem J, Vyzula R, Coudert B, Pacilio C, Prausova J, Hardy-Bessard AC, Arance A, Mukhopadhyay P, Aloe A, Roché H.

Clin Breast Cancer. 2015 Feb;15(1):8-15. doi: 10.1016/j.clbc.2014.07.007.

PMID: 25218708

 

Comparison of cardiac troponins I and T measured with high-sensitivity methods for evaluation of prognosis in atrial fibrillation: an ARISTOTLE substudy.

Hijazi Z, Siegbahn A, Andersson U, Lindahl B, Granger CB, Alexander JH, Atar D, Gersh BJ, Hanna M, Harjola VP, Horowitz J, Husted S, Hylek EM, Lopes RD, McMurray JJ, Wallentin L.

Clin Chem. 2015 Feb;61(2):368-78. doi: 10.1373/clinchem.2014.226936.

PMID: 25451868

 

Organic anion transporting polypeptide-mediated transport of, and inhibition by, asunaprevir, an inhibitor of hepatitis C virus NS3 protease.

Eley T, Han YH, Huang SP, He B, Li W, Bedford W, Stonier M, Gardiner D, Sims K, Rodrigues AD, Bertz RJ.

Clin Pharmacol Ther. 2015 Feb;97(2):159-66. doi: 10.1002/cpt.4.

PMID: 25670521

 

[Vigilance level for cardiovascular risk factors in schizophrenic patients].

Rouillon F, Van Ganse E, Vekhoff P, Arnaud R, Depret-Bixio L, Dillenschneider A.

Encephale. 2015 Feb;41(1):70-7. doi: 10.1016/j.encep.2014.12.003. French.

PMID: 25637197

 

Daclatasvir plus peginterferon and ribavirin is noninferior to peginterferon and ribavirin alone, and reduces the duration of treatment for HCV genotype 2 or 3 infection.

Dore GJ, Lawitz E, Hézode C, Shafran SD, Ramji A, Tatum HA, Taliani G, Tran A, Brunetto MR, Zaltron S, Strasser SI, Weis N, Ghesquiere W, Lee SS, Larrey D, Pol S, Harley H, George J, Fung SK, de Lédinghen V, Hagens P, McPhee F, Hernandez D, Cohen D, Cooney E, Noviello S, Hughes EA.

Gastroenterology. 2015 Feb;148(2):355-366.e1. doi: 10.1053/j.gastro.2014.10.007.

PMID: 25311593

 

Pharmacological characterization of a novel liver X receptor agonist with partial LXRα activity and a favorable window in nonhuman primates.

Kirchgessner TG, Martin R, Sleph P, Grimm D, Liu X, Lupisella J, Smalley J, Narayanan R, Xie Y, Ostrowski J, Cantor GH, Mohan R, Kick E.

J Pharmacol Exp Ther. 2015 Feb;352(2):305-14. doi: 10.1124/jpet.114.219923.

PMID: 25467132

 

Prospective, randomized, multi-institutional clinical trial of a silver alginate dressing to reduce lower extremity vascular surgery wound complications.

Ozaki CK, Hamdan AD, Barshes NR, Wyers M, Hevelone ND, Belkin M, Nguyen LL.

J Vasc Surg. 2015 Feb;61(2):419-427.e1. doi: 10.1016/j.jvs.2014.07.034.

PMID: 25175629

 

IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines.

Huang F, Chang H, Greer A, Hillerman S, Reeves KA, Hurlburt W, Cogswell J, Patel D, Qi Z, Fairchild C, Ryseck RP, Wong TW, Finckenstein FG, Jackson J, Carboni JM.

Mol Cancer Ther. 2015 Feb;14(2):620-30. doi: 10.1158/1535-7163.MCT-14-0794-T.

PMID: 25527633

 

Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor.

Carter PH, Dean T, Bhayana B, Khatri A, Rajur R, Gardella TJ.

Mol Endocrinol. 2015 Feb;29(2):307-21. doi: 10.1210/me.2014-1129.

PMID: 25584411

 

Long-term safety and efficacy of atazanavir-based therapy in HIV-infected infants, children and adolescents: the Pediatric AIDS Clinical Trials Group Protocol 1020A.

Rutstein RM, Samson P, Fenton T, Fletcher CV, Kiser JJ, Mofenson LM, Smith E, Graham B, Mathew M, Aldrovani G; PACTG 1020A Study Team..

Pediatr Infect Dis J. 2015 Feb;34(2):162-7. doi: 10.1097/INF.0000000000000538.

PMID: 25232777

 

The effect of polymeric excipients on the physical properties and performance of amorphous dispersions: Part I, free volume and glass transition.

Li J, Zhao J, Tao L, Wang J, Waknis V, Pan D, Hubert M, Raghavan K, Patel J.

Pharm Res. 2015 Feb;32(2):500-15. doi: 10.1007/s11095-014-1478-0.

PMID: 25107427

 

Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action.

Langley DR, Kimura SR, Sivaprakasam P, Zhou N, Dicker I, McAuliffe B, Wang T, Kadow JF, Meanwell NA, Krystal M.

Proteins. 2015 Feb;83(2):331-50. doi: 10.1002/prot.24726.

PMID: 25401969

 

Safety, pharmacokinetic, and positron emission tomography evaluation of serotonin and dopamine transporter occupancy following multiple-dose administration of the triple monoamine reuptake inhibitor BMS-820836.

Zheng M, Appel L, Luo F, Lane R, Burt D, Risinger R, Antoni G, Cahir M, Keswani S, Hayes W, Bhagwagar Z.

Psychopharmacology (Berl). 2015 Feb;232(3):529-40. doi: 10.1007/s00213-014-3688-x.

PMID: 25116481

 

The role of observational studies in optimizing the clinical management of chronic myeloid leukemia.

Mauro MJ, Davis C, Zyczynski T, Khoury HJ.

Ther Adv Hematol. 2015 Feb;6(1):3-14. doi: 10.1177/2040620714560305. Review.

PMID: 25642311

 

Estimating the clinical and economic benefit associated with incremental improvements in sustained virologic response in chronic hepatitis C.

McEwan P, Ward T, Bennett H, Kalsekar A, Webster S, Brenner M, Yuan Y.

PLoS One. 2015 Jan 30;10(1):e0117334. doi: 10.1371/journal.pone.0117334.

PMID: 25635922

 

Evaluation of clinical trials by Ethics Committees in Germany--results and a comparison of two surveys performed among members of the German Association of Research-Based Pharmaceutical Companies (vfa).

Russ H, Busta S, Jost B, Bethke TD.

Ger Med Sci. 2015 Jan 27;13:Doc02. doi: 10.3205/000206.

PMID: 25698912

 

Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy.

Chen K, Yang D, Li X, Sun B, Song F, Cao W, Brat DJ, Gao Z, Li H, Liang H, Zhao Y, Zheng H, Li M, Buckner J, Patterson SD, Ye X, Reinhard C, Bhathena A, Joshi D, Mischel PS, Croce CM, Wang YM, Raghavakaimal S, Li H, Lu X, Pan Y, Chang H, Ba S, Luo L, Cavenee WK, Zhang W, Hao X.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1107-12. doi: 10.1073/pnas.1422640112.

PMID: 25583476

 

The association of the treatment with glucagon-like peptide-1 receptor agonist exenatide or insulin with cardiovascular outcomes in patients with type 2 diabetes: a retrospective observational study.

Paul SK, Klein K, Maggs D, Best JH.

Cardiovasc Diabetol. 2015 Jan 24;14:10. doi: 10.1186/s12933-015-0178-3.

PMID: 25616979

 

Lethality of PAK3 and SGK2 shRNAs to human papillomavirus positive cervical cancer cells is independent of PAK3 and SGK2 knockdown.

Zhou N, Ding B, Agler M, Cockett M, McPhee F.

PLoS One. 2015 Jan 23;10(1):e0117357. doi: 10.1371/journal.pone.0117357.

PMID: 25615606

 

PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma.

Ansell SM, Lesokhin AM, Borrello I, Halwani A, Scott EC, Gutierrez M, Schuster SJ, Millenson MM, Cattry D, Freeman GJ, Rodig SJ, Chapuy B, Ligon AH, Zhu L, Grosso JF, Kim SY, Timmerman JM, Shipp MA, Armand P.

N Engl J Med. 2015 Jan 22;372(4):311-9. doi: 10.1056/NEJMoa1411087.

PMID: 25482239

 

Nivolumab in previously untreated melanoma without BRAF mutation.

Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbé C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Arance A, Schmidt H, Schadendorf D, Gogas H, Lundgren-Eriksson L, Horak C, Sharkey B, Waxman IM, Atkinson V, Ascierto PA.

N Engl J Med. 2015 Jan 22;372(4):320-30. doi: 10.1056/NEJMoa1412082.

PMID: 25399552

 

Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding.

Lu J, Chu J, Zou Z, Hamacher NB, Rixon MW, Sun PD.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):833-8. doi: 10.1073/pnas.1418812112.

PMID: 25561553

 

Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ.

Kick E, Martin R, Xie Y, Flatt B, Schweiger E, Wang TL, Busch B, Nyman M, Gu XH, Yan G, Wagner B, Nanao M, Nguyen L, Stout T, Plonowski A, Schulman I, Ostrowski J, Kirchgessner T, Wexler R, Mohan R.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):372-7. doi: 10.1016/j.bmcl.2014.11.029.

PMID: 25435151

 

Modelling drug degradation in a spray dried polymer dispersion using a modified Arrhenius equation.

Patterson A, Ferreira AP, Banks E, Skeene K, Clarke G, Nicholson S, Rawlinson-Malone C.

Int J Pharm. 2015 Jan 15;478(1):348-60. doi: 10.1016/j.ijpharm.2014.11.063.

PMID: 25450477

 

High Reproducibility of ELISPOT Counts from Nine Different Laboratories.

Sundararaman S, Karulin AY, Ansari T, BenHamouda N, Gottwein J, Laxmanan S, Levine SM, Loffredo JT, McArdle S, Neudoerfl C, Roen D, Silina K, Welch M, Lehmann PV.

Cells. 2015 Jan 9;4(1):21-39. doi: 10.3390/cells4010021.

PMID: 25585297

 

A Claisen approach to 4'-Ed4T.

Gallagher WP, Deshpande PP, Li J, Katipally K, Sausker J.

Org Lett. 2015 Jan 2;17(1):14-7. doi: 10.1021/ol503095v.

PMID: 25522212

 

microRNAs and Prostate Cancer.

Josson S, Chung LW, Gururajan M.

Adv Exp Med Biol. 2015;889:105-18. doi: 10.1007/978-3-319-23730-5_7.

PMID: 26658999

 

Quality assurance of metabolomics.

Bouhifd M, Beger R, Flynn T, Guo L, Harris G, Hogberg H, Kaddurah-Daouk R, Kamp H, Kleensang A, Maertens A, Odwin-DaCosta S, Pamies D, Robertson D, Smirnova L, Sun J, Zhao L, Hartung T.

ALTEX. 2015;32(4):319-26. doi: 10.14573/altex.1509161.

PMID: 26536290

 

Clinical events after transitioning from apixaban versus warfarin to warfarin at the end of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.

Granger CB, Lopes RD, Hanna M, Ansell J, Hylek EM, Alexander JH, Thomas L, Wang J, Bahit MC, Verheugt F, Lawrence J, Xavier D, Wallentin L.

Am Heart J. 2015 Jan;169(1):25-30. doi: 10.1016/j.ahj.2014.09.006. Erratum in: Am Heart J. 2015 Apr;169(4):594.

PMID: 25497244

 

Evaluating drug-free remission with abatacept in early rheumatoid arthritis: results from the phase 3b, multicentre, randomised, active-controlled AVERT study of 24 months, with a 12-month, double-blind treatment period.

Emery P, Burmester GR, Bykerk VP, Combe BG, Furst DE, Barré E, Karyekar CS, Wong DA, Huizinga TW.

Ann Rheum Dis. 2015 Jan;74(1):19-26. doi: 10.1136/annrheumdis-2014-206106.

PMID: 25367713

 

Single-dose pharmacokinetics and safety of daclatasvir in subjects with renal function impairment.

Garimella T, Wang R, Luo WL, Hwang C, Sherman D, Kandoussi H, Marbury TC, Alcorn H, Bertz R, Bifano M.

Antivir Ther. 2015;20(5):535-43. doi: 10.3851/IMP2941.

PMID: 25654812

 

A randomized trial in healthy subjects to assess the bioequivalence of an atazanavir/cobicistat fixed-dose combination tablet versus administration as separate agents.

Sevinsky H, Tao X, Wang R, Ravindran P, Sims K, Xu X, Jariwala N, Bertz R.

Antivir Ther. 2015;20(5):493-500. doi: 10.3851/IMP2913.

PMID: 25361436

 

The effect of hepatic impairment on the pharmacokinetics of asunaprevir, an HCV NS3 protease inhibitor.

Eley T, He B, Chang I, Colston E, Child M, Bedford W, Kandoussi H, Pasquinelli C, Marbury TC, Bertz RJ.

Antivir Ther. 2015;20(1):29-37. doi: 10.3851/IMP2773.

PMID: 24704773

 

2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 1 - small molecules by LCMS).

Welink J, Fluhler E, Hughes N, Arnold M, Garofolo F, Bustard M, Coppola L, Dhodda R, Evans C, Gleason C, Haidar S, Hayes R, Heinig K, Katori N, Blaye OL, Li W, Liu G, Lima Santos GM, Meng M, Nicholson B, Savoie N, Skelly M, Sojo L, Tampal N, de Merbel Nv, Verhaeghe T, Vinter S, Wickremsinhe E, Whale E, Wilson A, Witte B, Woolf E.

Bioanalysis. 2015;7(22):2913-25. doi: 10.4155/bio.15.204.

PMID: 26573485

 

Development and characterization of antibody reagents to assess anti-PEG IgG antibodies in clinical samples.

Krishna M, Palme H, Duo J, Lin Z, Corbett M, Dodge R, Piccoli S, Myler H, Pillutla R, Desilva B.

Bioanalysis. 2015;7(15):1869-83. doi: 10.4155/bio.15.112.

PMID: 26295988

 

Scientific or regulated validation: a tiered approach? Meeting report from a joint EBF/DVDMDG workshop.

Timmerman P, Lowes S, McDougall S, Colligon I, Miksic J, Chowdhury S, White S, Aubry AF, Jenkins R, Kemper C.

Bioanalysis. 2015;7(14):1703-10. doi: 10.4155/bio.15.115.

PMID: 26270777

 

Recommendations for the development and validation of confirmatory anti-drug antibody assays.

Jani D, Marsden R, Mikulskis A, Gleason C, Klem T, Krinos Fiorotti C, Myler H, Yang L, Fiscella M.

Bioanalysis. 2015;7(13):1619-31. doi: 10.4155/bio.15.96.

PMID: 26226311

 

An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study.

Myler H, Rangan VS, Wang J, Kozhich A, Cummings JA, Neely R, Dail D, Liu A, Wang B, Vezina HE, Freebern W, Sung MC, Passmore D, Deshpande S, Kempe T, Gu H, Saewert M, Manney A, Lute J, Zambito F, Wong RL, Piccoli SP, Aubry AF, Pillutla R, Arnold M, DeSilva B.

Bioanalysis. 2015;7(13):1569-82. doi: 10.4155/bio.15.80.

PMID: 26226308

 

Challenges in antibody-drug conjugate discovery: a bioconjugation and analytical perspective.

Rao C, Rangan VS, Deshpande S.

Bioanalysis. 2015;7(13):1561-4. doi: 10.4155/bio.15.81. No abstract available.

PMID: 26226306

 

Biotransformation and stability of antibody-drug conjugates: payload metabolism and linker cleavage delineation.

Rangan VS, Myler H, Kozhich A, Wang J, Randazzo R, Deshpande S.

Bioanalysis. 2015;7(11):1319-23. doi: 10.4155/bio.15.50. No abstract available.

PMID: 26110704

 

Stability assessment in ligand-binding assays: a critical parameter for data integrity.

Thway TM, DeSilva B.

Bioanalysis. 2015;7(11):1315-7. doi: 10.4155/bio.15.71. No abstract available.

PMID: 26110703

 

Which Metrics Are Appropriate to Describe the Value of New Cancer Therapies?

Johnson P, Greiner W, Al-Dakkak I, Wagner S.

Biomed Res Int. 2015;2015:865101. doi: 10.1155/2015/865101. Review.

PMID: 26161418

 

Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors.

Glunz PW, Cheng X, Cheney DL, Weigelt CA, Wei A, Luettgen JM, Wong PC, Wexler RR, Priestley ES.

Bioorg Med Chem Lett. 2015;25(10):2169-73. doi: 10.1016/j.bmcl.2015.03.062.

PMID: 25881820

 

Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications.

Burford NT, Traynor JR, Alt A.

Br J Pharmacol. 2015 Jan;172(2):277-86. doi: 10.1111/bph.12599. Review.

PMID: 24460691

 

A retrospective analysis of cross-reacting cetuximab IgE antibody and its association with severe infusion reactions.

Maier S, Chung CH, Morse M, Platts-Mills T, Townes L, Mukhopadhyay P, Bhagavatheeswaran P, Racenberg J, Trifan OC.

Cancer Med. 2015 Jan;4(1):36-42. doi: 10.1002/cam4.333.

PMID: 25296628

 

Incidence of type 2 diabetes among patients exposed to the combination of pravastatin and paroxetine.

Gooden KM, Bibeau KB, Wood J, Irizarry MC, Pan X, Allen J, Sampson T, Heim JM.

Curr Drug Saf. 2015;10(2):152-8.

PMID: 24861991

 

Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer.

Vassal G, Rousseau R, Blanc P, Moreno L, Bode G, Schwoch S, Schrappe M, Skolnik J, Bergman L, Bradley-Garelik MB, Saha V, Pearson A, Zwierzina H.

Eur J Cancer. 2015 Jan;51(2):218-24. doi: 10.1016/j.ejca.2014.10.029.

PMID: 25434924

 

Quality of Care for Patients with Type 2 Diabetes Mellitus in Dubai: A HEDIS-Like Assessment.

Szabo SM, Osenenko KM, Qatami L, Korenblat Donato BM, Korol EE, Al Madani AA, Al Awadi FF, Al-Ansari J, Maclean R, Levy AR.

Int J Endocrinol. 2015;2015:413276. doi: 10.1155/2015/413276.

PMID: 26089885

 

Changes in bone mineral density after 96 weeks of treatment with atazanavir/ritonavir or lopinavir/ritonavir plus tenofovir DF/emtricitabine in treatment-naive patients with HIV-1 infection: the CASTLE body composition substudy.

Moyle GJ, Hardy H, Farajallah A, McGrath SJ, Kaplita S, Ward D.

J Acquir Immune Defic Syndr. 2015 Jan 1;68(1):40-5. doi: 10.1097/QAI.0000000000000383.

PMID: 25296097

 

A novel route to recognizing quaternary ammonium cations using electrospray mass spectrometry.

Shackman HM, Ding W, Bolgar MS.

J Am Soc Mass Spectrom. 2015 Jan;26(1):181-9. doi: 10.1007/s13361-014-1019-4.

PMID: 25391726

 

Derivation of Phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 2: Exposure-response analyses for efficacy and safety variables.

Hruska M, Wang X, Chan P, Ahmad A, Freeman J, Horga MA, Hillson J, Kansra V, Lopez-Talavera JC.

J Clin Pharmacol. 2015 Jan;55(1):73-80. doi: 10.1002/jcph.361.

PMID: 25042797

 

Quantification of HBsAg in nucleos(t)ide-naïve patients treated for chronic hepatitis B with entecavir with or without tenofovir in the BE-LOW study.

Zoulim F, Carosi G, Greenbloom S, Mazur W, Nguyen T, Jeffers L, Brunetto M, Yu S, Llamoso C.

J Hepatol. 2015 Jan;62(1):56-63. doi: 10.1016/j.jhep.2014.08.031.

PMID: 25176615

 

Detection of drug specific circulating immune complexes from in vivo cynomolgus monkey serum samples.

Pierog P, Krishna M, Yamniuk A, Chauhan A, DeSilva B.

J Immunol Methods. 2015 Jan;416:124-36. doi: 10.1016/j.jim.2014.11.007.

PMID: 25462536

 

Development and characterization of a pre-treatment procedure to eliminate human monoclonal antibody therapeutic drug and matrix interference in cell-based functional neutralizing antibody assays.

Xu W, Jiang H, Titsch C, Haulenbeek JR, Pillutla RC, Aubry AF, DeSilva BS, Arnold ME, Zeng J, Dodge RW.

J Immunol Methods. 2015 Jan;416:94-104. doi: 10.1016/j.jim.2014.11.005.

PMID: 25445325

 

Cardiovascular event costs in patients with Type 2 diabetes mellitus.

Johnston SS, Sheehan JJ, Shah M, Cappell K, Princic N, Smith D, Kalsekar I.

J Med Econ. 2015;18(12):1032-40. doi: 10.3111/13696998.2015.1074078.

PMID: 26189723

 

Cost-effectiveness of DTG + ABC/3TC versus EFV/TDF/FTC for first-line treatment of HIV-1 in the United States.

Peng S, Tafazzoli A, Dorman E, Rosenblatt L, Villasis-Keever A, Sorensen S.

J Med Econ. 2015;18(10):763-76. doi: 10.3111/13696998.2015.1046878.

PMID: 25934146

 

Transition metal-induced degradation of a pharmaceutical compound in reversed-phase liquid chromatographic analysis.

Wang Q, He BL, Zhang J, Huang Y, Kleintop B, Raglione T.

J Pharm Biomed Anal. 2015;111:288-96. doi: 10.1016/j.jpba.2015.04.005.

PMID: 25916912

 

Evaluating drug delivery with salt formation: Drug disproportionation studied in situ by ATR-FTIR imaging and Raman mapping.

Ewing AV, Wray PS, Clarke GS, Kazarian SG.

J Pharm Biomed Anal. 2015;111:248-56. doi: 10.1016/j.jpba.2015.03.040.

PMID: 25910459

 

Development of a simple method for quantitation of methanesulfonic acid at low ppm level using hydrophilic interaction chromatography coupled with ESI-MS.

Huang Z, Francis R, Zha Y, Ruan J.

J Pharm Biomed Anal. 2015 Jan;102:17-24. doi: 10.1016/j.jpba.2014.08.019.

PMID: 25218030

 

Pseudouridine in mRNA: Incorporation, Detection, and Recoding.

Wu G, Huang C, Yu YT.

Methods Enzymol. 2015;560:187-217. doi: 10.1016/bs.mie.2015.03.009.

PMID: 26253972

 

Multicolor Digital Flow Cytometry in Human Translational Immunology.

Joshi SR, Mohanty S, Shaw AC.

Methods Mol Biol. 2015;1343:53-64. doi: 10.1007/978-1-4939-2963-4_5.

PMID: 26420708

 

High-Throughput Screening for Allosteric Modulators of GPCRs.

Bertekap RL Jr, Burford NT, Li Z, Alt A.

Methods Mol Biol. 2015;1335:223-40. doi: 10.1007/978-1-4939-2914-6_15.

PMID: 26260604

 

Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.

Guo H, Cruz-Munoz ME, Wu N, Robbins M, Veillette A.

Mol Cell Biol. 2015 Jan;35(1):41-51. doi: 10.1128/MCB.01107-14.

PMID: 25312647

 

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.

Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M.

Nat Struct Mol Biol. 2015 Jan;22(1):37-43. doi: 10.1038/nsmb.2924.

PMID: 25437913

 

A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms.

Leane M, Pitt K, Reynolds G; Manufacturing Classification System (MCS) Working Group..

Pharm Dev Technol. 2015 Jan;20(1):12-21. doi: 10.3109/10837450.2014.954728. Review.

PMID: 25162770

 

Multivariate analysis in the pharmaceutical industry: enabling process understanding and improvement in the PAT and QbD era.

Ferreira AP, Tobyn M.

Pharm Dev Technol. 2015;20(5):513-27. doi: 10.3109/10837450.2014.898656. Review.

PMID: 24641280

 

Industry update: 1-30 April 2015.

Timmins P.

Ther Deliv. 2015;6(8):903-10. doi: 10.4155/TDE.15.49. No abstract available.

PMID: 26272086

 

  

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2014 Publications

Development of an ELP-Z based mAb affinity precipitation process using scaled-down filtration techniques.

Sheth RD, Bhut BV, Jin M, Li Z, Chen W, Cramer SM.

J Biotechnol. 2014 Dec 20;192 Pt A:11-9. doi: 10.1016/j.jbiotec.2014.09.020.

PMID: 25285370

 

In Vitro Assessment of Re-treatment Options for Patients with Hepatitis C Virus Genotype 1b Infection Resistant to Daclatasvir Plus Asunaprevir.

Friborg J, Zhou N, Han Z, Yang X, Falk P, Mendez P, McPhee F.

Infect Dis Ther. 2014 Dec 17. [Epub ahead of print]

PMID: 25516102

 

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.

Duan JJ, Lu Z, Jiang B, Yang BV, Doweyko LM, Nirschl DS, Haque LE, Lin S, Brown G, Hynes J Jr, Tokarski JS, Sack JS, Khan J, Lippy JS, Zhang RF, Pitt S, Shen G, Pitts WJ, Carter PH, Barrish JC, Nadler SG, Salter-Cid LM, McKinnon M, Fura A, Schieven GL, Wrobleski ST.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5721-6. doi: 10.1016/j.bmcl.2014.10.061.

PMID: 25453808

 

Electrophilicity of pyridazine-3-carbonitrile, pyrimidine-2-carbonitrile, and pyridine-carbonitrile derivatives: a chemical model to describe the formation of thiazoline derivatives in human liver microsomes.

Sinha S, Ahire D, Wagh S, Mullick D, Sistla R, Selvakumar K, Cortes JC, Putlur SP, Mandlekar S, Johnson BM.

Chem Res Toxicol. 2014 Dec 15;27(12):2052-61. doi: 10.1021/tx500256j.

PMID: 25372409

 

Management and clinical outcomes in patients treated with apixaban vs warfarin undergoing procedures.

Garcia D, Alexander JH, Wallentin L, Wojdyla DM, Thomas L, Hanna M, Al-Khatib SM, Dorian P, Ansell J, Commerford P, Flaker G, Lanas F, Vinereanu D, Xavier D, Hylek EM, Held C, Verheugt FW, Granger CB, Lopes RD.

Blood. 2014 Dec 11;124(25):3692-8. doi: 10.1182/blood-2014-08-595496.

PMID: 25320240

 

Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity.

Hangeland JJ, Friends TJ, Rossi KA, Smallheer JM, Wang C, Sun Z, Corte JR, Fang T, Wong PC, Rendina AR, Barbera FA, Bozarth JM, Luettgen JM, Watson CA, Zhang G, Wei A, Ramamurthy V, Morin PE, Bisacchi GS, Subramaniam S, Arunachalam P, Mathur A, Seiffert DA, Wexler RR, Quan ML.

J Med Chem. 2014 Dec 11;57(23):9915-32. doi: 10.1021/jm5010607.

PMID: 25405503

 

Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans.

Lu Y, Griffen SC, Boulton DW, Leil TA.

Front Pharmacol. 2014 Dec 10;5:274. doi: 10.3389/fphar.2014.00274.

PMID: 25540623

 

Controlling the chemical stability of a moisture-sensitive drug product through monitoring and identification of coating process microenvironment.

Kestur U, Pandey P, Badawy S, Lin J, Desai D.

Int J Pharm. 2014 Dec 10;476(1-2):93-8. doi: 10.1016/j.ijpharm.2014.09.030.

PMID: 25261712

 

Genetic basis for clinical response to CTLA-4 blockade in melanoma.

Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky JM, Desrichard A, Walsh LA, Postow MA, Wong P, Ho TS, Hollmann TJ, Bruggeman C, Kannan K, Li Y, Elipenahli C, Liu C, Harbison CT, Wang L, Ribas A, Wolchok JD, Chan TA.

N Engl J Med. 2014 Dec 4;371(23):2189-99. doi: 10.1056/NEJMoa1406498.

PMID: 25409260

 

Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.

Ciccimaro E, Ranasinghe A, D'Arienzo C, Xu C, Onorato J, Drexler DM, Josephs JL, Poss M, Olah T.

Anal Chem. 2014 Dec 2;86(23):11523-7. doi: 10.1021/ac502678y.

PMID: 25371986

 

Stable isotope labeling by amino acids in cell culture-based liquid chromatography-mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures.

Polson C, Cantone JL, Wei C, Drexler DM, Meredith JE Jr.

Anal Biochem. 2014 Dec 1;466:65-71. doi: 10.1016/j.ab.2014.08.011.

PMID: 25175011

 

Potency and resistance analysis of hepatitis C virus NS5B polymerase inhibitor BMS-791325 on all major genotypes.

Liu M, Tuttle M, Gao M, Lemm JA.

Antimicrob Agents Chemother. 2014 Dec;58(12):7416-23. doi: 10.1128/AAC.03851-14.

PMID: 25267677

 

Artifactual prolongation of activated partial thromboplastin time with PEGylated compounds in silica-based assays.

Murphy B, Parrula MC, Perigard CJ, Li J.

Blood Coagul Fibrinolysis. 2014 Dec;25(8):876-82. doi: 10.1097/MBC.0000000000000176.

PMID: 25192241

 

Efficacy of adjunctive aripiprazole in patients with major depressive disorder whose symptoms worsened with antidepressant monotherapy.

Nelson JC, Rahman Z, Laubmeier KK, Eudicone JM, McQuade RD, Berman RM, Marcus RN, Baker RA, Sheehan JJ.

CNS Spectr. 2014 Dec;19(6):528-34. doi: 10.1017/S109285291300103X.

PMID: 24642260

 

Novel tactics for designing water-soluble molecules in drug discovery.

Walker MA.

Expert Opin Drug Discov. 2014 Dec;9(12):1421-33. doi: 10.1517/17460441.2014.960839. Review.

PMID: 25226793

 

Labware additives identified to be selective monoamine oxidase-B inhibitors.

Stewart J, Drexler DM, Leet JE, McNaney CA, Herbst JJ.

J Biomol Screen. 2014 Dec;19(10):1409-14. doi: 10.1177/1087057114551523.

PMID: 25296658

 

A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection.

Muir AJ, Arora S, Everson G, Flisiak R, George J, Ghalib R, Gordon SC, Gray T, Greenbloom S, Hassanein T, Hillson J, Horga MA, Jacobson IM, Jeffers L, Kowdley KV, Lawitz E, Lueth S, Rodriguez-Torres M, Rustgi V, Shemanski L, Shiffman ML, Srinivasan S, Vargas HE, Vierling JM, Xu D, Lopez-Talavera JC, Zeuzem S; EMERGE study group..

J Hepatol. 2014 Dec;61(6):1238-46. doi: 10.1016/j.jhep.2014.07.022.

PMID: 25064437

 

Randomized trial of asunaprevir plus peginterferon alfa and ribavirin for previously untreated genotype 1 or 4 chronic hepatitis C.

Bronowicki JP, Ratziu V, Gadano A, Thuluvath PJ, Bessone F, Martorell CT, Pol S, Terg R, Younes Z, He B, Eley T, Cohen D, Yu F, Hernandez D, McPhee F, Mendez P, Hughes E.

J Hepatol. 2014 Dec;61(6):1220-7. doi: 10.1016/j.jhep.2014.07.011.

PMID: 25038486

 

Dynamically optimizing experiment schedules of a laboratory robot system with simulated annealing.

Cabrera C, Fine-Morris M, Pokross M, Kish K, Michalczyk S, Cahn M, Klei H, Russo MF.

J Lab Autom. 2014 Dec;19(6):517-27. doi: 10.1177/2211068214546493.

PMID: 25117530

 

Myocardial matrix metalloproteinase-2: inside out and upside down.

DeCoux A, Lindsey ML, Villarreal F, Garcia RA, Schulz R.

J Mol Cell Cardiol. 2014 Dec;77:64-72. doi: 10.1016/j.yjmcc.2014.09.016. Review.

PMID: 25261607

 

Oral delivery of highly lipophilic poorly water-soluble drugs: spray-dried dispersions to improve oral absorption and enable high-dose toxicology studies of a P2Y1 antagonist.

Chen XQ, Stefanski K, Shen H, Huang C, Caporuscio C, Yang W, Lam P, Su C, Gudmundsson O, Hageman M.

J Pharm Sci. 2014 Dec;103(12):3924-31. doi: 10.1002/jps.24199.

PMID: 25308627

 

The authors reply.

Kohan DE, Fioretto P, Tang W, List JF.

Kidney Int. 2014 Dec;86(6):1272. doi: 10.1038/ki.2014.291. No abstract available.

PMID: 25427094

 

Current Practice Patterns and Educational Needs of Rheumatologists Who Manage Patients with Rheumatoid Arthritis.

Glauser TA, Ruderman EM, Kummerle D, Kelly S.

Rheumatol Ther. 2014 Dec;1(1):31-44.

PMID: 27747761

 

Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats.

Subramanian M, Kurawattimath V, Pocha K, Freeden C, Rao I, Mariappan TT, Marathe PH, Vikramadithyan RK, Abraham P, Kulkarni CP, Katnapally P, Nutakki R, Paruchury S, Bhutani P, Mandlekar S.

Xenobiotica. 2014 Dec;44(12):1108-16. doi: 10.3109/00498254.2014.932470.

PMID: 24947446

 

Is hypoglycemia fear independently associated with health-related quality of life?

Shi L, Shao H, Zhao Y, Thomas NA.

Health Qual Life Outcomes. 2014 Nov 30;12:167. doi: 10.1186/s12955-014-0167-3.

PMID: 25433668

 

Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.

Rigat KL, Lu H, Wang YK, Argyrou A, Fanslau C, Beno B, Wang Y, Marcinkeviciene J, Ding M, Gentles RG, Gao M, Abell LM, Roberts SB.

J Biol Chem. 2014 Nov 28;289(48):33456-68. doi: 10.1074/jbc.M114.613653.

PMID: 25301950

 

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.

Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD.

Nature. 2014 Nov 27;515(7528):577-81. doi: 10.1038/nature13988.

PMID: 25428507

 

Independent and joint effect of type 2 diabetes and gastric and hepatobiliary diseases on risk of pancreatic cancer risk: 10-year follow-up of population-based cohort.

Lin CC, Chiang JH, Li CI, Hsieh TF, Liu CS, Lin WY, Lee YD, Li TC.

Br J Cancer. 2014 Nov 25;111(11):2180-6. doi: 10.1038/bjc.2014.525.

PMID: 25275365

 

Decoupling the contribution of dispersive and acid-base components of surface energy on the cohesion of pharmaceutical powders.

Shah UV, Olusanmi D, Narang AS, Hussain MA, Tobyn MJ, Heng JY.

Int J Pharm. 2014 Nov 20;475(1-2):592-6. doi: 10.1016/j.ijpharm.2014.09.018.

PMID: 25223493

 

Growth differentiation factor 15, a marker of oxidative stress and inflammation, for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.

Wallentin L, Hijazi Z, Andersson U, Alexander JH, De Caterina R, Hanna M, Horowitz JD, Hylek EM, Lopes RD, Asberg S, Granger CB, Siegbahn A; ARISTOTLE Investigators..

Circulation. 2014 Nov 18;130(21):1847-58. doi: 10.1161/CIRCULATIONAHA.114.011204.

PMID: 25294786

 

Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans.

Matuskey D, Bhagwagar Z, Planeta B, Pittman B, Gallezot JD, Chen J, Wanyiri J, Najafzadeh S, Ropchan J, Geha P, Huang Y, Potenza MN, Neumeister A, Carson RE, Malison RT.

Biol Psychiatry. 2014 Nov 15;76(10):816-22. doi: 10.1016/j.biopsych.2013.11.022.

PMID: 24433854

 

Beneficial effect of belatacept on health-related quality of life and perceived side effects: results from the BENEFIT and BENEFIT-EXT trials.

Dobbels F, Wong S, Min Y, Sam J, Kalsekar A.

Transplantation. 2014 Nov 15;98(9):960-8. doi: 10.1097/TP.0000000000000159.

PMID: 24831918

 

Adaptation of the pore diffusion model to describe multi-addition batch uptake high-throughput screening experiments.

Traylor SJ, Xu X, Li Y, Jin M, Li ZJ.

J Chromatogr A. 2014 Nov 14;1368:100-6. doi: 10.1016/j.chroma.2014.09.058.

PMID: 25311484

 

A randomized direct comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban.

Frost C, Song Y, Barrett YC, Wang J, Pursley J, Boyd RA, LaCreta F.

Clin Pharmacol. 2014 Nov 13;6:179-87. doi: 10.2147/CPAA.S61131.

PMID: 25419161

 

Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development.

Leil TA, Bertz R.

Front Pharmacol. 2014 Nov 10;5:247. doi: 10.3389/fphar.2014.00247.

PMID: 25426074

 

Evaluation of drug-drug interaction between daclatasvir and methadone or buprenorphine/naloxone.

Garimella T, Wang R, Luo WL, Wastall P, Kandoussi H, Demicco M, Bruce D, Hwang C, Bertz R, Bifano M.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19628. doi: 10.7448/IAS.17.4.19628.

PMID: 25394132

 

Cost-effectiveness of DTG+ABC/3TC versus EFV/TDF/FTC for first-line treatment of HIV-1 in the United States.

Peng S, Tafazzoli A, Dorman E, Rosenblatt L, Villasis-Keever A, Sorensen S.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19605. doi: 10.7448/IAS.17.4.19605.

PMID: 25394109

 

Nephrolithiasis and renal failure among patients exposed to atazanavir, other PIs and PI-free regimens.

Nkhoma E, Kumar M, Hines P, Moorthy V, Klauck I, Keever AV.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19560. doi: 10.7448/IAS.17.4.19560.

PMID: 25394067

 

No difference in persistence to treatment with atazanavir or darunavir in HIV patients in a real-world setting.

Farr AM, Johnston SS, Ritchings C, Brouillette M, Rosenblatt L.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19538. doi: 10.7448/IAS.17.4.19538.

PMID: 25394047

 

Safety profile of HIV-1 attachment inhibitor prodrug BMS-663068 in antiretroviral-experienced subjects: week 24 analysis.

Lalezari J, Latiff GH, Brinson C, Echevarria J, Treviño-Pérez S, Bogner JR, Stock D, Joshi SR, Hanna GJ, Lataillade M.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19530. doi: 10.7448/IAS.17.4.19530.

PMID: 25394039

 

HIV-1 attachment inhibitor prodrug BMS-663068 in antiretroviral-experienced subjects: week 24 sub-group analysis.

Brinson C, Lalezari J, Gulam LH, Thompson M, Echevarria J, Treviño-Pérez S, Stock D, Samit JR, George HJ, Lataillade M.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19529. doi: 10.7448/IAS.17.4.19529.

PMID: 25394038

 

Evaluation of acoustic membrane microparticle (AMMP) technology for a sensitive ligand binding assay to support pharmacokinetic determinations of a biotherapeutic.

Chilewski SD, Dickerson WM, Mora JR, Saab A, Alderman EM.

AAPS J. 2014 Nov;16(6):1366-71. doi: 10.1208/s12248-014-9659-7.

PMID: 25245223

 

Next generation ligand binding assays-review of emerging technologies' capabilities to enhance throughput and multiplexing.

Mora J, Given Chunyk A, Dysinger M, Purushothama S, Ricks C, Osterlund K, Theobald V.

AAPS J. 2014 Nov;16(6):1175-84. doi: 10.1208/s12248-014-9660-1. Review.

PMID: 25193269

 

Development of apixaban: a novel anticoagulant for prevention of stroke in patients with atrial fibrillation.

Hanna MS, Mohan P, Knabb R, Gupta E, Frost C, Lawrence JH.

Ann N Y Acad Sci. 2014 Nov;1329:93-106. doi: 10.1111/nyas.12567. Review.

PMID: 25377080

 

Survival follow-up and ipilimumab retreatment of patients with advanced melanoma who received ipilimumab in prior phase II studies.

Lebbé C, Weber JS, Maio M, Neyns B, Harmankaya K, Hamid O, O'Day SJ, Konto C, Cykowski L, McHenry MB, Wolchok JD.

Ann Oncol. 2014 Nov;25(11):2277-84. doi: 10.1093/annonc/mdu441.

PMID: 25210016

 

Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists.

Kim KS, Zhang L, Williams D, Perez HL, Stang E, Borzilleri RM, Posy S, Lei M, Chaudhry C, Emanuel S, Talbott R.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5022-9. doi: 10.1016/j.bmcl.2014.09.022.

PMID: 25278234

 

Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors for the treatment of metabolic disorders.

Yoon DS, Wu SC, Seethala R, Golla R, Nayeem A, Everlof JG, Gordon DA, Hamann LG, Robl JA.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5045-9. doi: 10.1016/j.bmcl.2014.09.012.

PMID: 25266782

 

Hypoxia influences protein transport and epigenetic repression of CHO cell cultures in shake flasks.

Qian Y, Xing Z, Lee S, Mackin NA, He A, Kayne PS, He Q, Qian NX, Li ZJ.

Biotechnol J. 2014 Nov;9(11):1413-24. doi: 10.1002/biot.201400315.

PMID: 25271019

 

Effects of glutamine and asparagine on recombinant antibody production using CHO-GS cell lines.

Xu P, Dai XP, Graf E, Martel R, Russell R.

Biotechnol Prog. 2014 Nov-Dec;30(6):1457-68. doi: 10.1002/btpr.1957.

PMID: 25079388

 

Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects.

Kasichayanula S, Boulton DW, Luo WL, Rodrigues AD, Yang Z, Goodenough A, Lee M, Jemal M, LaCreta F.

Br J Clin Pharmacol. 2014 Nov;78(5):1122-34. doi: 10.1111/bcp.12425.

PMID: 24837659

 

Bacillus Calmette-Guérin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice.

Vijaya Kumar K, Rudra A, Sreedhara MV, Siva Subramani T, Prasad DS, Das ML, Murugesan S, Yadav R, Trivedi RK, Louis JV, Li YW, Bristow LJ, Naidu PS, Vikramadithyan RK.

Brain Behav Immun. 2014 Nov;42:204-11. doi: 10.1016/j.bbi.2014.06.205.

PMID: 25016199

 

Reviewing a clinical decision aid for the selection of anticoagulation treatment in patients with nonvalvular atrial fibrillation: applications in a US managed care health plan database.

Deitelzweig SB, Jing Y, Swindle JP, Makenbaeva D.

Clin Ther. 2014 Nov 1;36(11):1566-1573.e3. doi: 10.1016/j.clinthera.2014.09.016.

PMID: 25438725

 

Postprandial dynamics of plasma glucose, insulin, and glucagon in patients with type 2 diabetes treated with saxagliptin plus dapagliflozin add-on to metformin therapy.

Hansen L, Iqbal N, Ekholm E, Cook W, Hirshberg B.

Endocr Pract. 2014 Nov;20(11):1187-97. doi: 10.4158/EP14489.OR.

PMID: 25370334

 

Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication.

Berger C, Romero-Brey I, Radujkovic D, Terreux R, Zayas M, Paul D, Harak C, Hoppe S, Gao M, Penin F, Lohmann V, Bartenschlager R.

Gastroenterology. 2014 Nov;147(5):1094-105.e25. doi: 10.1053/j.gastro.2014.07.019.

PMID: 25046163

 

The paradox of public participation in the healthcare in Poland--what citizens want, and what they think.

Kolasa K, Dohnalik J, Borek E, Siemiątkowski M, Scibiorski C.

Health Policy. 2014 Nov;118(2):159-65. doi: 10.1016/j.healthpol.2014.09.015.

PMID: 25445113

 

A commentary on scale-up of pan coating process using microenvironmental control.

Pandey P, Bindra DS.

J Pharm Sci. 2014 Nov;103(11):3412-5. doi: 10.1002/jps.24191. Review.

PMID: 25257120

 

Insight to the thermodynamic stability of molecular crystals through crystallographic studies of a multipolymorph system.

Ng AT, Lai C, Dabros M, Gao Q.

J Pharm Sci. 2014 Nov;103(11):3423-31. doi: 10.1002/jps.24135.

PMID: 25252084

 

Excipient-process interactions and their impact on tablet compaction and film coating.

Pandey P, Bindra DS, Gour S, Trinh J, Buckley D, Badawy S.

J Pharm Sci. 2014 Nov;103(11):3666-74. doi: 10.1002/jps.24169.

PMID: 25223603

 

Incidence and clinical features of drug-induced lung injury in patients with advanced colorectal cancer receiving cetuximab: results of a prospective multicenter registry.

Satoh T, Gemma A, Kudoh S, Sakai F, Yamaguchi K, Watanabe T, Ishiguro M, Inoshiri S, Izawa M, Sugihara K, Sakata Y.

Jpn J Clin Oncol. 2014 Nov;44(11):1032-9. doi: 10.1093/jjco/hyu128.

PMID: 25210144

 

 All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study.

Manns M, Pol S, Jacobson IM, Marcellin P, Gordon SC, Peng CY, Chang TT, Everson GT, Heo J, Gerken G, Yoffe B, Towner WJ, Bourliere M, Metivier S, Chu CJ, Sievert W, Bronowicki JP, Thabut D, Lee YJ, Kao JH, McPhee F, Kopit J, Mendez P, Linaberry M, Hughes E, Noviello S; HALLMARK-DUAL Study Team..

Lancet. 2014 Nov 1;384(9954):1597-605. doi: 10.1016/S0140-6736(14)61059-X. Erratum in: Lancet. 2014 Nov 1;384(9954):1576.

PMID: 25078304

 

Expanding public-private collaborations to enhance cancer drug development: a report of the Institute of Medicine's workshop series, "Implementing a National Cancer Clinical Trials System for the 21st Century".

Bertagnolli MM, Canetta R, Nass SJ.

Oncologist. 2014 Nov;19(11):1179-85. doi: 10.1634/theoncologist.2014-0240.

PMID: 25326161

 

A practical approach to a viral detection pipeline using existing viral and non-viral sequence resources.

Bekkari K, Shpungin J, Thompson JR.

PDA J Pharm Sci Technol. 2014 Nov-Dec;68(6):595-601. doi: 10.5731/pdajpst.2014.01022.

PMID: 25475634

 

Repeatability of metabolically active tumor volume measurements with FDG PET/CT in advanced gastrointestinal malignancies: a multicenter study.

Frings V, van Velden FH, Velasquez LM, Hayes W, van de Ven PM, Hoekstra OS, Boellaard R.

Radiology. 2014 Nov;273(2):539-48. doi: 10.1148/radiol.14132807.

PMID: 24865311

 

Use of animals for toxicology testing is necessary to ensure patient safety in pharmaceutical development.

Mangipudy R, Burkhardt J, Kadambi VJ.

Regul Toxicol Pharmacol. 2014 Nov;70(2):439-41. doi: 10.1016/j.yrtph.2014.07.014.

PMID: 25058855

 

Survey of Treatment Costs to Hepatitis C in China.

Duan ZP, Zhou HY, Duan C, Wang Z, Chen Y, Zheng SJ, Liu S, Tang A, Li H.

Value Health. 2014 Nov;17(7):A805. doi: 10.1016/j.jval.2014.08.515. No abstract available.

PMID: 27203036

 

Cost-Effectiveness of Antiviral Therapy for Chronic Hepatitis B: A Systematic Review.

Chen W, Tang Z, Wang X, Li J, Luo Z.

Value Health. 2014 Nov;17(7):A805. doi: 10.1016/j.jval.2014.08.518. No abstract available.

PMID: 27203032

 

From Regulatory Approval to Subsidised Patient Access in the Asia-Pacific Region: A Comparison of Systems Across Australia, China, Japan, Korea, New Zealand, Taiwan And Thailand.

Kim H, Jung H, Chou P, Kunihara T, Tosanguan J, Tang Z, Brydon S, Cook G.

Value Health. 2014 Nov;17(7):A794. doi: 10.1016/j.jval.2014.08.454. No abstract available.

PMID: 27202972

 

Discontinuation/Interruption of Warfarin Therapy in Patients with Non-Valvular Atrial Fibrillation.

Wang J, Qiao Y, Spivey CA, Liu X, Phatak H, Mardekian J, Claflin AB, Kachroo S, Abdulsatter Y, Parker RB.

Value Health. 2014 Nov;17(7):A763. doi: 10.1016/j.jval.2014.08.272. No abstract available.

PMID: 27202796

 

Health Care Utilization and Costs After Warfarin Discontinuation Among Patients with Non-Valvular Atrial Fibrillation.

Wang J, Qiao Y, Spivey CA, Liu X, Phatak H, Mardekian J, Claflin AB, Kachroo S, Abdulsatter Y, Parker RB.

Value Health. 2014 Nov;17(7):A756. doi: 10.1016/j.jval.2014.08.230. No abstract available.

PMID: 27202755

 

Cost Minimization Analysis Of Clinical Option Scenarios For Metformin And Acarbose In Treatment Of Type 2 Diabetes: Based On Direct And Indirect Treatment Comparison Results.

Gu S, Xu X, Shi L, Sawhney M, Hu H, Dong H.

Value Health. 2014 Nov;17(7):A745. doi: 10.1016/j.jval.2014.08.165. No abstract available.

PMID: 27202690

 

The Incidence, Prevalence, and Survival of Malignant Melanoma in Taiwan.

Chang HY, Feng HL, Wang L, Chou P, Wang PF.

Value Health. 2014 Nov;17(7):A740. doi: 10.1016/j.jval.2014.08.135. No abstract available.

PMID: 27202661

 

Anticipated Price Disclosure: Impact on Funding Decisions in Australia.

Harrison JP, Cook G, Kim H.

Value Health. 2014 Nov;17(7):A723-4. doi: 10.1016/j.jval.2014.08.037. No abstract available.

PMID: 27202568

 

Modelling the Relationship between Sustained Virologic Response and Treatment Uptake Rates on Future Prevalence and Incidence of Hepatitis C in the UK.

Bennett H, McEwan P, Ward T, Kalsekar A, Yuan Y.

Value Health. 2014 Nov;17(7):A682. doi: 10.1016/j.jval.2014.08.2547. No abstract available.

PMID: 27202526

 

The Epidemiologic Burden of Hepatitis C Virus Infection in Egypt.

Szabo SM, Juarez-Garcia A, Levy AR, Donato BM.

Value Health. 2014 Nov;17(7):A666. doi: 10.1016/j.jval.2014.08.2455. No abstract available.

PMID: 27202436

 

Cost-Effectiveness of Ipilimumab in Previously Untreated Patients for Advanced Melanoma in Sweden.

Barzey V, Asukai Y, Gueron B, Holmberg C, Kotapati S.

Value Health. 2014 Nov;17(7):A642-3. doi: 10.1016/j.jval.2014.08.2322. No abstract available.

PMID: 27202303

 

Patient Count Projections for Advanced Melanoma by Line of Therapy and Other Clinical Characteristics in EU Countries: Results from The UK, Germany, France, Italy and Spain (EU-5).

Gueron B, Kish JK, O'Day K, Martel MJ, Manley Daumont M.

Value Health. 2014 Nov;17(7):A619. doi: 10.1016/j.jval.2014.08.2191. No abstract available.

PMID: 27202177

 

The Relative Efficacy of Treatments in First-Line Management of Newly Diagnosed Chronic Myeloid Leukaemia: Systematic Literature Review and Indirect Comparison.

Kroes M, Zagorska A, Osei-Assibey G, Paine A.

Value Health. 2014 Nov;17(7):A615. doi: 10.1016/j.jval.2014.08.2165. No abstract available.

PMID: 27202156

 

Health Care Costs in Patients Treated with Ipilimumab for Advanced Melanoma Results of a Retrospective Chart Review.

Tarhini A, Rao AS, Corman S, Botteman M, Ji X, Mehta S, Margolin K.

Value Health. 2014 Nov;17(7):A615. doi: 10.1016/j.jval.2014.08.2167. No abstract available.

PMID: 27202153

 

Patient Reported Utilities In First-Line Advanced Or Metastatic Melanoma: Analysis Of Trial CA184-024.

Porter J, Lee D, Hertel N, Hatswell AJ.

Value Health. 2014 Nov;17(7):A569. doi: 10.1016/j.jval.2014.08.1900. No abstract available.

PMID: 27201894

 

Modelling Survival in the Presence of Different Mechanisms of Action: Ipilimumab and Vemurafenib in Advanced Melanoma.

Lee D, Porter J, Hertel N, Hatswell AJ.

Value Health. 2014 Nov;17(7):A557. doi: 10.1016/j.jval.2014.08.1832. No abstract available.

PMID: 27201833

 

Cost-Effectiveness Analysis of Ipilimumab in Previously Untreated Patients With Unresectable Malignant Melanoma in Scotland.

Lee D, Porter J, Hatswell AJ, Hertel N, Walker A.

Value Health. 2014 Nov;17(7):A549-50. doi: 10.1016/j.jval.2014.08.1789. No abstract available.

PMID: 27201787

 

Treatment Patterns and Health Resource Utilization Among Atrial Fibrillation Patients in United Arab Emirates and Saudi Arabia.

Johnston K, Osenenko KM, Donato BM, Qatami L, Alawi AA, Binbrek AS, Hersi AS, Mould JF, Levy AR.

Value Health. 2014 Nov;17(7):A504. doi: 10.1016/j.jval.2014.08.1527. No abstract available.

PMID: 27201532

 

Clinical and Demographics Characteristics of Non-Valvular Atrial Fibrillation Patients Switching From Warfarin To Novel Oral Anticoagulants.

Kachroo S, Pan X, Liu L, Kawabata H, Phatak H.

Value Health. 2014 Nov;17(7):A500-1. doi: 10.1016/j.jval.2014.08.1506. No abstract available.

PMID: 27201512

 

Literature Review Of Pro Measures Assessing Anticoagulant Therapy.

Barrett AM, Harris NI, DeMuro C, Kachroo S, Phatak H.

Value Health. 2014 Nov;17(7):A495-6. doi: 10.1016/j.jval.2014.08.1477. No abstract available.

PMID: 27201485

 

Cost-Effectiveness Of Apixaban Compared To Other Anticoagulants For Lifetime Treatment And Prevention Of Recurrent Venous Thromboembolism.

Lanitis T, Hamilton M, Rublee DA, Leipold R, Quon P, Browne C, Cohen AT.

Value Health. 2014 Nov;17(7):A488. doi: 10.1016/j.jval.2014.08.1434. No abstract available.

PMID: 27201443

 

Cost Effectiveness Analysis Of Apixaban Versus Other Noacs For The Prevention Of Stroke In Italian Non-Valvular Atrial Fibrillation Patients.

Pradelli L, Calandriello M, Di VR, Bellone M, Tubaro M.

Value Health. 2014 Nov;17(7):A487-8. doi: 10.1016/j.jval.2014.08.1432. No abstract available.

PMID: 27201441

 

Pharmacoeconomic Assessment Of Apixaban Versus Standard Of Care For The Prevention Of Stroke In Italian Non-Valvular Atrial Fibrillation Patients.

Pradelli L, Calandriello M, Di VR, Bellone M, Tubaro M.

Value Health. 2014 Nov;17(7):A486-7. doi: 10.1016/j.jval.2014.08.1427. No abstract available.

PMID: 27201435

 

Burden Of Cardiovascular Complications In Patients With Atrial Fibrillation In France.

Fauchier L, Samson A, Chaize G, Gaudin AF, Vainchtock A, Bailly C, Cotté FE.

Value Health. 2014 Nov;17(7):A483. doi: 10.1016/j.jval.2014.08.1404. No abstract available.

PMID: 27201414

 

Budget Impact Analysis Of Apixaban Versus Other Noacs For The Prevention Of Stroke In Italian Non-Valvular Atrial Fibrillation Patients.

Pradelli L, Calandriello M, Di VR, Bellone M, Tubaro M.

Value Health. 2014 Nov;17(7):A479. doi: 10.1016/j.jval.2014.08.1383. No abstract available.

PMID: 27201393

 

Risk Factors Associated With Venous Thromboembolism Recurrence In A European Population.

Hamilton M, Gupta S, Goren A, Auziere S, Claflin AB, Reboul R, Phatak H.

Value Health. 2014 Nov;17(7):A477. doi: 10.1016/j.jval.2014.08.1369. No abstract available.

PMID: 27201384

 

Real World Incidences And Hospital Cost Of Venous And Pulmonary Thromboembolic Events In France.

Bouee S, Emery C, Samson A, Bailly C, Cotté FE.

Value Health. 2014 Nov;17(7):A477. doi: 10.1016/j.jval.2014.08.1370. No abstract available.

PMID: 27201381

 

Lifetime Clinical Events Avoided And Resource Utilization With Apixaban Compared To Low-Molecular-Weight Heparin Followed By A Vitamin K Antagonist For The Treatment And Prevention Of Venous Thromboembolism.

Hamilton M, Phatak H, Lanitis T, Mardekian J, Rublee DA, Leipold R, Quon P, Browne C, Cohen AT.

Value Health. 2014 Nov;17(7):A475. doi: 10.1016/j.jval.2014.08.1358. No abstract available.

PMID: 27201370

 

Comparison of Post-Authorisation Measures From Regulatory Authorities With Additional Evidence Requirements From HTA Bodies in Germany.

Ruof J, Staab TR, Slawik L, Orben T, Bosch S.

Value Health. 2014 Nov;17(7):A427. doi: 10.1016/j.jval.2014.08.1073. No abstract available.

PMID: 27201102

 

Characterizing Work Productivity Loss In Incident Rheumatoid Arthritis In Sweden.

Banefelt J, Gustavsson A, Borgström F, Alemao E.

Value Health. 2014 Nov;17(7):A383. doi: 10.1016/j.jval.2014.08.2629. No abstract available.

PMID: 27200860

 

Treating to the Target of Das28 < 2.6 in Rheumatoid Arthritis: the Impact of Efficacy on Cost Effectiveness.

Alemao E, Johal S, Al MJ, Rutten-van MM.

Value Health. 2014 Nov;17(7):A378-9. doi: 10.1016/j.jval.2014.08.2605. No abstract available.

PMID: 27200834

 

Drug Usage Analysis and Health Care Resources Consumption in Patients With Rheumatoid Arthritis.

Degli EL, Sangiorgi D, Calandriello M, Buda S.

Value Health. 2014 Nov;17(7):A373. doi: 10.1016/j.jval.2014.08.2576. No abstract available.

PMID: 27200805

 

Real World Studies Using Japanese Administrative Databases: Chronic Hepatitis C Treatment Pattern And Resource Use.

Crawford B, Tang A, Li H, Burns L, Wada K, McDonald J.

Value Health. 2014 Nov;17(7):A370-1. doi: 10.1016/j.jval.2014.08.843. No abstract available.

PMID: 27200790

 

Mean Annual Cost Of Patients Hospitalized For Chronic Hepatitis C In France: The Hepc-Lone Study.

Abergel A, Rotily M, Gaudin AF, De LL, Vainchtock A, Akremi R, Branchoux S.

Value Health. 2014 Nov;17(7):A364. doi: 10.1016/j.jval.2014.08.809. No abstract available.

PMID: 27200756

 

Burden Of Hospitalizations Related To Chronic Hepatitis C In France: Evolution Between 2009 And 2012.

Rotily M, Abergel A, Branchoux S, De LL, Vainchtock A, Akremi R, Gaudin AF.

Value Health. 2014 Nov;17(7):A364. doi: 10.1016/j.jval.2014.08.808. No abstract available.

PMID: 27200755

 

Treatment Patterns Among Type 2 Diabetes Mellitus Patients in Saudi Arabia.

Levy AR, Szabo SM, Osenenko KM, Korol EE, Qatami L, Al JS, Al SA, Al SS, Maclean R, Donato BM.

Value Health. 2014 Nov;17(7):A362. doi: 10.1016/j.jval.2014.08.795. No abstract available.

PMID: 27200742

 

Glycemic, Lipid, and Blood Pressure Control Among Individuals with Type 2 Diabetes Mellitus in Saudi Arabia.

Osenenko KM, Szabo SM, Donato BM, Korol EE, Qatami L, Al Jaser S, Al Saggabi A, El Seid ME, Maclean R, Levy AR.

Value Health. 2014 Nov;17(7):A333-4. doi: 10.1016/j.jval.2014.08.635. No abstract available.

PMID: 27200581

 

The Cost of Costing Treatments Incorrectly: Errors in the Application of Drug Prices in Economic Models Due to Differing Patient Weights.

Hatswell AJ, Porter J, Hertel N, Lee D.

Value Health. 2014 Nov;17(7):A323-4. doi: 10.1016/j.jval.2014.08.568. No abstract available.

PMID: 27200530

 

P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development.

Garcia RA, Yan M, Search D, Zhang R, Carson NL, Ryan CS, Smith-Monroy C, Zheng J, Chen J, Kong Y, Tang H, Hellings SE, Wardwell-Swanson J, Dinchuk JE, Psaltis GC, Gordon DA, Glunz PW, Gargalovic PS.

PLoS One. 2014 Oct 31;9(10):e111385. doi: 10.1371/journal.pone.0111385.

PMID: 25360548

 

Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial.

Scirica BM, Braunwald E, Raz I, Cavender MA, Morrow DA, Jarolim P, Udell JA, Mosenzon O, Im K, Umez-Eronini AA, Pollack PS, Hirshberg B, Frederich R, Lewis BS, McGuire DK, Davidson J, Steg PG, Bhatt DL; SAVOR-TIMI 53 Steering Committee and Investigators*..

Circulation. 2014 Oct 28;130(18):1579-88. doi: 10.1161/CIRCULATIONAHA.114.010389. Erratum in: Circulation. 2015 Oct 13;132(15):e198.

PMID: 25189213

 

Five-step authorship framework to improve transparency in disclosing contributors to industry-sponsored clinical trial publications.

Marušić A, Hren D, Mansi B, Lineberry N, Bhattacharya A, Garrity M, Clark J, Gesell T, Glasser S, Gonzalez J, Hustad C, Lannon MM, Mooney LA, Peña T.

BMC Med. 2014 Oct 24;12:197. doi: 10.1186/s12916-014-0197-z.

PMID: 25604352

 

Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models.

Ermakov S, Forster P, Pagidala J, Miladinov M, Wang A, Baillie R, Bartlett D, Reed M, Leil TA.

Front Pharmacol. 2014 Oct 22;5:232. doi: 10.3389/fphar.2014.00232.

PMID: 25374542

 

Resource use and cost implications of implementing a heart failure program for patients with systolic heart failure in Swedish primary health care.

Agvall B, Paulsson T, Foldevi M, Dahlström U, Alehagen U.

Int J Cardiol. 2014 Oct 20;176(3):731-8. doi: 10.1016/j.ijcard.2014.07.105.

PMID: 25131925

 

Gene signature-guided dasatinib therapy in metastatic breast cancer.

Pusztai L, Moulder S, Altan M, Kwiatkowski D, Valero V, Ueno NT, Esteva FJ, Avritscher R, Qi Y, Strauss L, Hortobagyi GN, Hatzis C, Symmans WF.

Clin Cancer Res. 2014 Oct 15;20(20):5265-71. doi: 10.1158/1078-0432.CCR-14-0800. Erratum in: Clin Cancer Res. 2015 Jun 1;21(11):2653.

PMID: 25172932

 

Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay.

Yuan L, Fu Y, Zhang D, Xia YQ, Peng Q, Aubry AF, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:60-8. doi: 10.1016/j.jchromb.2014.08.006.

PMID: 25151331

 

Amiodarone, anticoagulation, and clinical events in patients with atrial fibrillation: insights from the ARISTOTLE trial.

Flaker G, Lopes RD, Hylek E, Wojdyla DM, Thomas L, Al-Khatib SM, Sullivan RM, Hohnloser SH, Garcia D, Hanna M, Amerena J, Harjola VP, Dorian P, Avezum A, Keltai M, Wallentin L, Granger CB; ARISTOTLE Committees and Investigators..

J Am Coll Cardiol. 2014 Oct 14;64(15):1541-50. doi: 10.1016/j.jacc.2014.07.967.

PMID: 25301455

 

Ipilimumab administration for advanced melanoma in patients with pre-existing Hepatitis B or C infection: a multicenter, retrospective case series.

Ravi S, Spencer K, Ruisi M, Ibrahim N, Luke JJ, Thompson JA, Shirai K, Lawson D, Bartell H, Kudchadkar R, Gunter NT, Mehnert JM, Lipson EJ.

J Immunother Cancer. 2014 Oct 14;2(1):33. doi: 10.1186/s40425-014-0033-1.

PMID: 25317333

 

A validated LC-MS/MS method for the simultaneous determination of BMS-791325, a hepatitis C virus NS5B RNA polymerase inhibitor, and its metabolite in plasma.

Yuan L, Jiang H, Zheng N, Xia YQ, Ouyang Z, Zeng J, Akinsanya B, Valentine JL, Moehlenkamp JD, Deng Y, Aubry AF, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 12;973C:1-8. doi: 10.1016/j.jchromb.2014.10.005. [Epub ahead of print]

PMID: 25464088

 

Insights into chiral recognition mechanism in supercritical fluid chromatography III. Non-halogenated polysaccharide stationary phases.

Khater S, Zhang Y, West C.

J Chromatogr A. 2014 Oct 10;1363:278-93. doi: 10.1016/j.chroma.2014.06.084.

PMID: 25035237

 

Insights into chiral recognition mechanism in supercritical fluid chromatography IV. Chlorinated polysaccharide stationary phases.

Khater S, Zhang Y, West C.

J Chromatogr A. 2014 Oct 10;1363:294-310. doi: 10.1016/j.chroma.2014.06.026.

PMID: 24973802

 

Understanding API-polymer proximities in amorphous stabilized composite drug products using fluorine-carbon 2D HETCOR solid-state NMR.

Abraham A, Crull G.

Mol Pharm. 2014 Oct 6;11(10):3754-9. doi: 10.1021/mp400629j.

PMID: 25152063

 

Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry.

Huang RY, Chen G.

Anal Bioanal Chem. 2014 Oct;406(26):6541-58. doi: 10.1007/s00216-014-7924-3. Review.

PMID: 24948090

 

Evaluation of the effect of naproxen on the pharmacokinetics and pharmacodynamics of apixaban.

Frost C, Shenker A, Gandhi MD, Pursley J, Barrett YC, Wang J, Zhang D, Byon W, Boyd RA, LaCreta F.

Br J Clin Pharmacol. 2014 Oct;78(4):877-85. doi: 10.1111/bcp.12393.

PMID: 24697979

 

4-Benzothiazole-7-hydroxyindolinyl diaryl ureas are potent P2Y1 antagonists with favorable pharmacokinetics: low clearance and small volume of distribution.

Qiao JX, Wang TC, Hiebert S, Hu CH, Schumacher WA, Spronk SA, Clark CG, Han Y, Hua J, Price LA, Shen H, Chacko SA, Everlof G, Bostwick JS, Steinbacher TE, Li YX, Huang CS, Seiffert DA, Rehfuss R, Wexler RR, Lam PY.

ChemMedChem. 2014 Oct;9(10):2327-43. doi: 10.1002/cmdc.201402141.

PMID: 24989964

 

Glucagon-like peptide 1 receptor agonist or bolus insulin with optimized basal insulin in type 2 diabetes.

Diamant M, Nauck MA, Shaginian R, Malone JK, Cleall S, Reaney M, de Vries D, Hoogwerf BJ, MacConell L, Wolffenbuttel BH; 4B Study Group..

Diabetes Care. 2014 Oct;37(10):2763-73. doi: 10.2337/dc14-0876.

PMID: 25011946

 

The glucagon-like peptide-1-based therapeutics exenatide and saxagliptin did not cause detrimental effects on the pancreas in mice, rats, dogs and monkeys.

Roy D, Chadwick KD, Tatarkiewicz K, LaCerte C, Bergholm AM, Brodie T, Mangipudy RS, Parkes D, Graziano MJ, Reilly TP.

Diabetes Obes Metab. 2014 Oct;16(10):910-21. doi: 10.1111/dom.12294.

PMID: 24666399

 

Safety profile of dapagliflozin for type 2 diabetes: pooled analysis of clinical studies for overall safety and rare events.

Ptaszynska A, Johnsson KM, Parikh SJ, de Bruin TW, Apanovitch AM, List JF.

Drug Saf. 2014 Oct;37(10):815-29. doi: 10.1007/s40264-014-0213-4.

PMID: 25096959

 

Effects of pramlintide in patients with type 2 diabetes mellitus: an analysis using daily insulin dose tertiles.

Herrmann K, Shan K, Brunell SC, Chen S.

Endocr Pract. 2014 Oct;20(10):1070-5. doi: 10.4158/EP13477.OR.

PMID: 25100363

 

Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen.

Burford NT, Wehrman T, Bassoni D, O'Connell J, Banks M, Zhang L, Alt A.

J Biomol Screen. 2014 Oct;19(9):1255-65. doi: 10.1177/1087057114542975.

PMID: 25047277

 

Clinical effectiveness of stress-reduction techniques in patients with hypertension: systematic review and meta-analysis.

Nagele E, Jeitler K, Horvath K, Semlitsch T, Posch N, Herrmann KH, Grouven U, Hermanns T, Hemkens LG, Siebenhofer A.

J Hypertens. 2014 Oct;32(10):1936-44; discussion 1944. doi: 10.1097/HJH.0000000000000298. Review.

PMID: 25084308

 

The synthesis of 14C-labeled N-succinimidyl-3-maleimidopropionate, a linker molecule for PEGylated biologics.

Cao K, Maxwell BD, Bonacorsi SJ.

J Labelled Comp Radiopharm. 2014 Oct;57(12):667-9. doi: 10.1002/jlcr.3225.

PMID: 25303408

 

Utilization of Zwitterion-based solutions to dissect the relative effects of solution pH and ionic strength on the aggregation behavior and conformational stability of a fusion protein.

Zhou R, Nashine V, Palm T, Gandhi R, Adams M.

J Pharm Sci. 2014 Oct;103(10):3065-74. doi: 10.1002/jps.24118.

PMID: 25139470

 

A combination turbidity and supernatant microplate assay to rank-order the supersaturation limits of early drug candidates.

Morrison JS, Nophsker MJ, Haskell RJ.

J Pharm Sci. 2014 Oct;103(10):3022-32. doi: 10.1002/jps.24090.

PMID: 25070886

 

Peak purity assessment in a triple-active fixed-dose combination drug product related substances method using a commercial two-dimensional liquid chromatography system.

Shackman JG, Kleintop BL.

J Sep Sci. 2014 Oct;37(19):2688-95. doi: 10.1002/jssc.201400515.

PMID: 25045066

 

Using Modified RECIST and Alpha-Fetoprotein Levels to Assess Treatment Benefit in Hepatocellular Carcinoma.

Raoul JL, Park JW, Kang YK, Finn RS, Kim JS, Yeo W, Polite BN, Chao Y, Walters I, Baudelet C, Lencioni R.

Liver Cancer. 2014 Oct;3(3-4):439-50. doi: 10.1159/000343872. Review.

PMID: 26280005

 

Nontraditional applications in clinical pathology.

Jordan HL, Register TC, Tripathi NK, Bolliger AP, Everds N, Zelmanovic D, Poitout F, Bounous DI, Wescott D, Ramaiah SK.

Toxicol Pathol. 2014 Oct;42(7):1058-68. doi: 10.1177/0192623314522109. Review.

PMID: 24705882

 

Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease.

McCrindle BW, Li JS, Manlhiot C, Tweddell JS, Giglia TM, Massicotte MP, Monagle P, Krishnamurthy R, Mahaffey KW, Michelson AD, Verdun N, Almond CS, Newburger JW, Brandão LR, Esmon CT, Manco-Johnson MJ, Ichord R, Ortel TL, Chan AK, Portman R, Rose M, Strony J, Kaltman JR.

Circulation. 2014 Sep 30;130(14):1192-203. doi: 10.1161/CIRCULATIONAHA.113.008428. No abstract available.

PMID: 25266860

 

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells.

Lin H, Chen M, Rothe K, Lorenzi MV, Woolfson A, Jiang X.

Oncotarget. 2014 Sep 30;5(18):8637-50.

PMID: 25226617

 

Reverse transcriptase and intron number evolution.

Zhou K, Kuo A, Grigoriev IV.

Stem Cell Investig. 2014 Sep 28;1:17. doi: 10.3978/j.issn.2306-9759.2014.08.01.

PMID: 27358863

 

Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119.

Wacker DA, Wang Y, Broekema M, Rossi K, O'Connor S, Hong Z, Wu G, Malmstrom SE, Hung CP, LaMarre L, Chimalakonda A, Zhang L, Xin L, Cai H, Chu C, Boehm S, Zalaznick J, Ponticiello R, Sereda L, Han SP, Zebo R, Zinker B, Luk CE, Wong R, Everlof G, Li YX, Wu CK, Lee M, Griffen S, Miller KJ, Krupinski J, Robl JA.

J Med Chem. 2014 Sep 25;57(18):7499-508. doi: 10.1021/jm501175v.

PMID: 25208139

 

Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate.

Washburn WN, Manfredi M, Devasthale P, Zhao G, Ahmad S, Hernandez A, Robl JA, Wang W, Mignone J, Wang Z, Ngu K, Pelleymounter MA, Longhi D, Zhao R, Wang B, Huang N, Flynn N, Azzara AV, Barrish JC, Rohrbach K, Devenny JJ, Rooney S, Thomas M, Glick S, Godonis HE, Harvey SJ, Cullen MJ, Zhang H, Caporuscio C, Stetsko P, Grubb M, Maxwell BD, Yang H, Apedo A, Gemzik B, Janovitz EB, Huang C, Zhang L, Freeden C, Murphy BJ.

J Med Chem. 2014 Sep 25;57(18):7509-22. doi: 10.1021/jm500026w.

PMID: 25165888

 

Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis.

Santella JB 3rd, Gardner DS, Duncia JV, Wu H, Dhar M, Cavallaro C, Tebben AJ, Carter PH, Barrish JC, Yarde M, Briceno SW, Cvijic ME, Grafstrom RR, Liu R, Patel SR, Watson AJ, Yang G, Rose AV, Vickery RD, Caceres-Cortes J, Caporuscio C, Camac DM, Khan JA, An Y, Foster WR, Davies P, Hynes J Jr.

J Med Chem. 2014 Sep 25;57(18):7550-64. doi: 10.1021/jm5003167.

PMID: 25101488

 

Synthesis of the 6-azaindole containing HIV-1 attachment inhibitor pro-drug, BMS-663068.

Chen K, Risatti C, Bultman M, Soumeillant M, Simpson J, Zheng B, Fanfair D, Mahoney M, Mudryk B, Fox RJ, Hsaio Y, Murugesan S, Conlon DA, Buono FG, Eastgate MD.

J Org Chem. 2014 Sep 19;79(18):8757-67. doi: 10.1021/jo5016008.

PMID: 25144249

 

Model-based exposure-response analysis of apixaban to quantify bleeding risk in special populations of subjects undergoing orthopedic surgery.

Leil TA, Frost C, Wang X, Pfister M, LaCreta F.

CPT Pharmacometrics Syst Pharmacol. 2014 Sep 17;3:e136. doi: 10.1038/psp.2014.34.

PMID: 25229619

 

Selecting the correct weighting factors for linear and quadratic calibration curves with least-squares regression algorithm in bioanalytical LC-MS/MS assays and impacts of using incorrect weighting factors on curve stability, data quality, and assay performance.

Gu H, Liu G, Wang J, Aubry AF, Arnold ME.

Anal Chem. 2014 Sep 16;86(18):8959-66. doi: 10.1021/ac5018265.

PMID: 25157966

 

Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab.

Santegoets SJ, Stam AG, Lougheed SM, Gall H, Jooss K, Sacks N, Hege K, Lowy I, Scheper RJ, Gerritsen WR, van den Eertwegh AJ, de Gruijl TD.

J Immunother Cancer. 2014 Sep 16;2:31. doi: 10.1186/s40425-014-0031-3.

PMID: 26196012

 

Identification of human liver microsomal proteins adducted by a reactive metabolite using shotgun proteomics.

Yang Y, Xiao Q, Humphreys WG, Dongre A, Shu YZ.

Chem Res Toxicol. 2014 Sep 15;27(9):1537-46. doi: 10.1021/tx500181p.

PMID: 25105203

 

Development of an LC-MS/MS method for high throughput quantification of metformin uptake in transporter inhibition assays.

Vath M, Gallagher L, Shou W, Weller H, Elkin L, Zhang J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:211-8. doi: 10.1016/j.jchromb.2014.07.024.

PMID: 25125398

 

Effect of crystal habits on the surface energy and cohesion of crystalline powders.

Shah UV, Olusanmi D, Narang AS, Hussain MA, Gamble JF, Tobyn MJ, Heng JY.

Int J Pharm. 2014 Sep 10;472(1-2):140-7. doi: 10.1016/j.ijpharm.2014.06.014.

PMID: 24928138

 

Tandem ring-closing metathesis/transfer hydrogenation: practical chemoselective hydrogenation of alkenes.

Connolly T, Wang Z, Walker MA, McDonald IM, Peese KM.

Org Lett. 2014 Sep 5;16(17):4444-7. doi: 10.1021/ol5019739.

PMID: 25140991

 

Long-term safety and tolerability of saxagliptin add-on therapy in older patients (aged ≥ 65 years) with type 2 diabetes.

Iqbal N, Allen E, Öhman P.

Clin Interv Aging. 2014 Sep 4;9:1479-87. doi: 10.2147/CIA.S68193.

PMID: 25214775

 

No evident association between efavirenz use and suicidality was identified from a disproportionality analysis using the FAERS database.

Napoli AA, Wood JJ, Coumbis JJ, Soitkar AM, Seekins DW, Tilson HH.

J Int AIDS Soc. 2014 Sep 4;17:19214. doi: 10.7448/IAS.17.1.19214.

PMID: 25192857

 

Efficacy and safety of apixaban compared with warfarin for stroke prevention in patients with atrial fibrillation from East Asia: a subanalysis of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial.

Goto S, Zhu J, Liu L, Oh BH, Wojdyla DM, Aylward P, Bahit MC, Gersh BJ, Hanna M, Horowitz J, Lopes RD, Wallentin L, Xavier D, Alexander JH; ARISTOTLE Investigators..

Am Heart J. 2014 Sep;168(3):303-9. doi: 10.1016/j.ahj.2014.06.005.

PMID: 25173541

 

Comparison of daclatasvir resistance barriers on NS5A from hepatitis C virus genotypes 1 to 6: implications for cross-genotype activity.

Wang C, Jia L, O'Boyle DR 2nd, Sun JH, Rigat K, Valera L, Nower P, Huang X, Kienzle B, Roberts S, Gao M, Fridell RA.

Antimicrob Agents Chemother. 2014 Sep;58(9):5155-63. doi: 10.1128/AAC.02788-14.

PMID: 24936600

 

Current advances and strategies towards fully automated sample preparation for regulated LC-MS/MS bioanalysis.

Zheng N, Jiang H, Zeng J.

Bioanalysis. 2014 Sep;6(18):2441-59. doi: 10.4155/bio.14.161. Review.

PMID: 25384595

 

Development and validation of an LC-MS/MS assay for the quantitation of a PEGylated anti-CD28 domain antibody in human serum: overcoming interference from antidrug antibodies and soluble target.

Gong C, Zeng J, Akinsanya B, Jiang H, Mora J, Chilewski S, Gambardella J, Allentoff A, Gleason C, Aubry AF, DeSilva BS, Arnold ME.

Bioanalysis. 2014 Sep;6(18):2371-83. doi: 10.4155/bio.14.181.

PMID: 25384590

 

In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates.

Wang C, Thudium KB, Han M, Wang XT, Huang H, Feingersh D, Garcia C, Wu Y, Kuhne M, Srinivasan M, Singh S, Wong S, Garner N, Leblanc H, Bunch RT, Blanset D, Selby MJ, Korman AJ.

Cancer Immunol Res. 2014 Sep;2(9):846-56. doi: 10.1158/2326-6066.CIR-14-0040.

PMID: 24872026

 

The pharmacokinetics of daclatasvir and asunaprevir administered in combination in studies in healthy subjects and patients infected with hepatitis C virus.

Eley T, Sevinsky H, Huang SP, He B, Zhu K, Kandoussi H, Gardiner D, Grasela DM, Bertz R, Bifano M.

Clin Drug Investig. 2014 Sep;34(9):661-71. doi: 10.1007/s40261-014-0219-9.

PMID: 25117173

 

Vitamin K antagonist treatment in patients with atrial fibrillation and time in therapeutic range in four European countries.

Cotté FE, Benhaddi H, Duprat-Lomon I, Doble A, Marchant N, Letierce A, Huguet M.

Clin Ther. 2014 Sep 1;36(9):1160-8. doi: 10.1016/j.clinthera.2014.07.016.

PMID: 25151574

 

Incidence of pancreatitis and pancreatic cancer in a randomized controlled multicenter trial (SAVOR-TIMI 53) of the dipeptidyl peptidase-4 inhibitor saxagliptin.

Raz I, Bhatt DL, Hirshberg B, Mosenzon O, Scirica BM, Umez-Eronini A, Im K, Stahre C, Buskila A, Iqbal N, Greenberger N, Lerch MM.

Diabetes Care. 2014 Sep;37(9):2435-41. doi: 10.2337/dc13-2546.

PMID: 24914244

 

Retrospective cohort study evaluating exenatide twice daily and long-acting insulin analogs in a Veterans Health Administration population with type 2 diabetes.

Bounthavong M, Tran JN, Golshan S, Piland NF, Morello CM, Blickensderfer A, Best JH.

Diabetes Metab. 2014 Sep;40(4):284-91. doi: 10.1016/j.diabet.2014.06.002.

PMID: 25059703

 

New advances in treating thrombotic diseases.

Schumacher WA, Wang X, Wong PC.

Drug Discov Today. 2014 Sep;19(9):1433-4. doi: 10.1016/j.drudis.2014.06.015. No abstract available.

PMID: 24959954

 

Tissue factor-fVIIa inhibition: update on an unfinished quest for a novel oral antithrombotic.

Priestley ES.

Drug Discov Today. 2014 Sep;19(9):1440-4. doi: 10.1016/j.drudis.2014.05.023. Review.

PMID: 24881783

 

Enabled clinical use of an HIV-1 attachment inhibitor through drug delivery.

Timmins P, Brown J, Meanwell NA, Hanna GJ, Zhu L, Kadow JF.

Drug Discov Today. 2014 Sep;19(9):1288-93. doi: 10.1016/j.drudis.2014.03.025.

PMID: 24727410

 

New models for elevating the practice and status of community-based nursing across the spectrum of cancer care in Central and Eastern Europe.

Grimes C, Wanless RS, Damonti J.

Eur J Oncol Nurs. 2014 Sep;18 Suppl 2:S97-122. doi: 10.1016/j.ejon.2014.07.008. Erratum in: Eur J Oncol Nurs. 2014 Dec;18(6):649.

PMID: 25174879

 

Suppression of peak tailing of phosphate prodrugs in reversed-phase liquid chromatography.

Zhang J, Wang Q, Kleintop B, Raglione T.

J Pharm Biomed Anal. 2014 Sep;98:247-52. doi: 10.1016/j.jpba.2014.05.027.

PMID: 24946148

 

Burden of corticosteroid use in patients with systemic lupus erythematosus: results from a Delphi panel.

Petri M, Bechtel B, Dennis G, Shah M, McLaughlin T, Kan H, Molta C.

Lupus. 2014 Sep;23(10):1006-13. doi: 10.1177/0961203314532699.

PMID: 24786783

 

Introduction to the HESI DART Drugs in Semen Consortium.

Chen CL, Beyer BK, Breslin WJ, DeLise AM, Hui JY, Moffat GJ, Thompson KE.

Reprod Toxicol. 2014 Sep;48:113-4. doi: 10.1016/j.reprotox.2014.04.007. No abstract available.

PMID: 24803405

 

Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.

Wes PD, Easton A, Corradi J, Barten DM, Devidze N, DeCarr LB, Truong A, He A, Barrezueta NX, Polson C, Bourin C, Flynn ME, Keenan S, Lidge R, Meredith J, Natale J, Sankaranarayanan S, Cadelina GW, Albright CF, Cacace AM.

PLoS One. 2014 Aug 25;9(8):e106050. doi: 10.1371/journal.pone.0106050. Erratum in: PLoS One. 2015;10(3):e0121509.

PMID: 25153994

 

A novel and cost effective method of removing excess albumin from plasma/serum samples and its impacts on LC-MS/MS bioanalysis of therapeutic proteins.

Liu G, Zhao Y, Angeles A, Hamuro LL, Arnold ME, Shen JX.

Anal Chem. 2014 Aug 19;86(16):8336-43. doi: 10.1021/ac501837t.

PMID: 25083595

 

Stability of indomethacin with relevance to the release from amorphous solid dispersions studied with ATR-FTIR spectroscopic imaging.

Ewing AV, Clarke GS, Kazarian SG.

Eur J Pharm Sci. 2014 Aug 18;60:64-71. doi: 10.1016/j.ejps.2014.05.001.

PMID: 24832964

 

Monoamine reuptake site occupancy of sibutramine: Relationship to antidepressant-like and thermogenic effects in rats.

Li YW, Langdon S, Pieschl R, Strong T, Wright RN, Rohrbach K, Lelas S, Lodge NJ.

Eur J Pharmacol. 2014 Aug 15;737:47-56. doi: 10.1016/j.ejphar.2014.03.024.

PMID: 24821570

 

Monitoring process induced attrition of drug substance particles within formulated blends.

Gamble JF, Hoffmann M, Hughes H, Hutchins P, Tobyn M.

Int J Pharm. 2014 Aug 15;470(1-2):77-87. doi: 10.1016/j.ijpharm.2014.04.028.

PMID: 24793838

 

Prolonged immunosuppression preserves nonsensitization status after kidney transplant failure.

Casey MJ, Wen X, Kayler LK, Aiyer R, Scornik JC, Meier-Kriesche HU.

Transplantation. 2014 Aug 15;98(3):306-11. doi: 10.1097/TP.0000000000000057.

PMID: 24717218

 

Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID.

Gong J, Gu X, Achanzar WE, Chadwick KD, Gan J, Brock BJ, Kishnani NS, Humphreys WG, Iyer RA.

Anal Chem. 2014 Aug 5;86(15):7642-9. doi: 10.1021/ac501507g.

PMID: 25003239

 

NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats.

Sivarao DV, Chen P, Yang Y, Li YW, Pieschl R, Ahlijanian MK.

Front Psychiatry. 2014 Aug 5;5:96. doi: 10.3389/fpsyt.2014.00096.

PMID: 25140157

 

Determination of residual acetone and acetone related impurities in drug product intermediates prepared as Spray Dried Dispersions (SDD) using gas chromatography with headspace autosampling (GCHS).

Quirk E, Doggett A, Bretnall A.

J Pharm Biomed Anal. 2014 Aug 5;96:37-44. doi: 10.1016/j.jpba.2014.03.027.

PMID: 24721204

 

Economic evaluation of apixaban for the prevention of stroke in non-valvular atrial fibrillation in the Netherlands.

Stevanović J, Pompen M, Le HH, Rozenbaum MH, Tieleman RG, Postma MJ.

PLoS One. 2014 Aug 5;9(8):e103974. doi: 10.1371/journal.pone.0103974.

PMID: 25093723

 

Independent data monitoring committees: preparing a path for the future.

Hess CN, Roe MT, Gibson CM, Temple RJ, Pencina MJ, Zarin DA, Anstrom KJ, Alexander JH, Sherman RE, Fiedorek FT, Mahaffey KW, Lee KL, Chow SC, Armstrong PW, Califf RM.

Am Heart J. 2014 Aug;168(2):135-41.e1. doi: 10.1016/j.ahj.2014.05.003.

PMID: 25066551

 

Bioavailability of therapeutic proteins by inhalation--worker safety aspects.

Pfister T, Dolan D, Bercu J, Gould J, Wang B, Bechter R, Barle EL, Pfannkuch F, Flueckiger A.

Ann Occup Hyg. 2014 Aug;58(7):899-911. doi: 10.1093/annhyg/meu038. Review.

PMID: 24958792

 

LC-MS/MS determination of apixaban (BMS-562247) and its major metabolite in human plasma: an application of polarity switching and monolithic HPLC column.

Pursley J, Shen JX, Schuster A, Dang OT, Lehman J, Buonarati MH, Song Y, Aubry AF, Arnold ME.

Bioanalysis. 2014 Aug;6(15):2071-82. doi: 10.4155/bio.14.66.

PMID: 25322783

 

Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.

Gong H, Yang M, Xiao Z, Doweyko AM, Cunningham M, Wang J, Habte S, Holloway D, Burke C, Shuster D, Gao L, Carman J, Somerville JE, Nadler SG, Salter-Cid L, Barrish JC, Weinstein DS.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3268-73. doi: 10.1016/j.bmcl.2014.06.010.

PMID: 24980053

 

Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties.

Orwat MJ, Qiao JX, He K, Rendina AR, Luettgen JM, Rossi KA, Xin B, Knabb RM, Wexler RR, Lam PY, Pinto DJ.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3341-5. doi: 10.1016/j.bmcl.2014.05.101.

PMID: 24951330

 

Affinity precipitation of a monoclonal antibody from an industrial harvest feedstock using an ELP-Z stimuli responsive biopolymer.

Sheth RD, Jin M, Bhut BV, Li Z, Chen W, Cramer SM.

Biotechnol Bioeng. 2014 Aug;111(8):1595-603. doi: 10.1002/bit.25230.

PMID: 24595842

 

Cancer immunotherapy highlights from the 2014 ASCO Meeting.

Harshman LC, Drake CG, Wargo JA, Sharma P, Bhardwaj N.

Cancer Immunol Res. 2014 Aug;2(8):714-9. doi: 10.1158/2326-6066.CIR-14-0119.

PMID: 25092813

 

Saxagliptin improves glycemic control by modulating postprandial glucagon and C-peptide levels in Chinese patients with type 2 diabetes.

Sjöstrand M, Iqbal N, Lu J, Hirshberg B.

Diabetes Res Clin Pract. 2014 Aug;105(2):185-91. doi: 10.1016/j.diabres.2014.05.006.

PMID: 24947443

 

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.

Salphati L, Chu X, Chen L, Prasad B, Dallas S, Evers R, Mamaril-Fishman D, Geier EG, Kehler J, Kunta J, Mezler M, Laplanche L, Pang J, Rode A, Soars MG, Unadkat JD, van Waterschoot RA, Yabut J, Schinkel AH, Scheer N.

Drug Metab Dispos. 2014 Aug;42(8):1301-13. doi: 10.1124/dmd.114.057976.

PMID: 24855184

 

Treatment patterns, complications, and disease relapse in a real-world population of patients with moderate-to-severe ulcerative colitis initiating immunomodulator therapy.

Loftus EV Jr, Davis KL, Wang CC, Dastani H, Luo A.

Inflamm Bowel Dis. 2014 Aug;20(8):1361-7. doi: 10.1097/MIB.0000000000000089.

PMID: 24918320

 

Therapeutic potential of chloroquine in a murine model of inflammatory bowel disease.

Nagar J, Ranade S, Kamath V, Singh S, Karunanithi P, Subramani S, Venkatesh K, Srivastava R, Dudhgaonkar S, Vikramadithyan RK.

Int Immunopharmacol. 2014 Aug;21(2):328-35. doi: 10.1016/j.intimp.2014.05.005.

PMID: 24859061

 

Integrating High-Content Analysis into a Multiplexed Screening Approach to Identify and Characterize GPCR Agonists.

Zhu Y, Watson J, Chen M, Shen DR, Yarde M, Agler M, Burford N, Alt A, Jayachandra S, Cvijic ME, Zhang L, Dyckman A, Xie J, O'Connell J, Banks M, Weston A.

J Biomol Screen. 2014 Aug;19(7):1079-89. doi: 10.1177/1087057114533146.

PMID: 24789006

 

Chronic lumbar intrathecal catheterization for the collection of cerebrospinal fluid in the canine.

West W, Ehrmann J, Johnson W.

J Invest Surg. 2014 Aug;27(4):226-33. doi: 10.3109/08941939.2014.882450.

PMID: 24694254

 

Synthesis of carbon-14 and stable isotope labeled Avagacestat: a novel gamma secretase inhibitor for the treatment of Alzheimer's disease.

Burrell RC, Easter JA, Cassidy MP, Gillman KW, Olson RE, Bonacorsi SJ.

J Labelled Comp Radiopharm. 2014 Aug;57(10):600-5. doi: 10.1002/jlcr.3224.

PMID: 25196195

 

Challenges in accurate quantitation of lysophosphatidic acids in human biofluids.

Onorato JM, Shipkova P, Minnich A, Aubry AF, Easter J, Tymiak A.

J Lipid Res. 2014 Aug;55(8):1784-96. doi: 10.1194/jlr.D050070.

PMID: 24872406

 

Pharmacologic profile of the Adnectin BMS-962476, a small protein biologic alternative to PCSK9 antibodies for low-density lipoprotein lowering.

Mitchell T, Chao G, Sitkoff D, Lo F, Monshizadegan H, Meyers D, Low S, Russo K, DiBella R, Denhez F, Gao M, Myers J, Duke G, Witmer M, Miao B, Ho SP, Khan J, Parker RA.

J Pharmacol Exp Ther. 2014 Aug;350(2):412-24. doi: 10.1124/jpet.114.214221.

PMID: 24917546

 

Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents.

Yang W, Wang Y, Lai A, Qiao JX, Wang TC, Hua J, Price LA, Shen H, Chen XQ, Wong P, Crain E, Watson C, Huang CS, Seiffert DA, Rehfuss R, Wexler RR, Lam PY.

J Med Chem. 2014 Jul 24;57(14):6150-64. doi: 10.1021/jm5006226.

PMID: 24931384

 

Efficacy and safety of apixaban compared with aspirin in patients who previously tried but failed treatment with vitamin K antagonists: results from the AVERROES trial.

Coppens M, Synhorst D, Eikelboom JW, Yusuf S, Shestakovska O, Connolly SJ.

Eur Heart J. 2014 Jul 21;35(28):1856-63. doi: 10.1093/eurheartj/ehu048.

PMID: 24569032

 

Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial.

Halvorsen S, Atar D, Yang H, De Caterina R, Erol C, Garcia D, Granger CB, Hanna M, Held C, Husted S, Hylek EM, Jansky P, Lopes RD, Ruzyllo W, Thomas L, Wallentin L.

Eur Heart J. 2014 Jul 21;35(28):1864-72. doi: 10.1093/eurheartj/ehu046.

PMID: 24561548

 

Cost-effectiveness of apixaban vs. current standard of care for stroke prevention in patients with atrial fibrillation.

Dorian P, Kongnakorn T, Phatak H, Rublee DA, Kuznik A, Lanitis T, Liu LZ, Iloeje U, Hernandez L, Lip GY.

Eur Heart J. 2014 Jul 21;35(28):1897-906. doi: 10.1093/eurheartj/ehu006.

PMID: 24513791

 

Initiation of warfarin in patients with atrial fibrillation: early effects on ischaemic strokes.

Azoulay L, Dell'Aniello S, Simon TA, Renoux C, Suissa S.

Eur Heart J. 2014 Jul 21;35(28):1881-7. doi: 10.1093/eurheartj/eht499.

PMID: 24353282

 

Quality by design development of brivanib alaninate tablets: degradant and moisture control strategy.

Badawy SI, Lin J, Gokhale M, Desai S, Nesarikar VV, LaMarche KR, Subramanian GA, Narang AS.

Int J Pharm. 2014 Jul 20;469(1):111-20. doi: 10.1016/j.ijpharm.2014.04.059.

PMID: 24780101

 

Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors.

Johnson JA, Xu N, Jeon Y, Finlay HJ, Kover A, Conder ML, Sun H, Li D, Levesque P, Hsueh MM, Harper TW, Wexler RR, Lloyd J.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3018-22. doi: 10.1016/j.bmcl.2014.05.035.

PMID: 24881565

 

Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum.

Zhang H, Xiao Q, Xin B, Trigona W, Tymiak AA, Dongre AR, Olah TV.

Rapid Commun Mass Spectrom. 2014 Jul 15;28(13):1535-43. doi: 10.1002/rcm.6928.

PMID: 24861605

 

The effect of additives on the zinc carbenoid-mediated cyclopropanation of a dihydropyrrole.

Ramirez A, Truc VC, Lawler M, Ye YK, Wang J, Wang C, Chen S, Laporte T, Liu N, Kolotuchin S, Jones S, Bordawekar S, Tummala S, Waltermire RE, Kronenthal D.

J Org Chem. 2014 Jul 3;79(13):6233-43. doi: 10.1021/jo500966m.

PMID: 24915024

 

Quantitative targeted proteomics for membrane transporter proteins: method and application.

Qiu X, Zhang H, Lai Y.

AAPS J. 2014 Jul;16(4):714-26. doi: 10.1208/s12248-014-9607-6. Review.

PMID: 24830943

 

Justifying reimbursement for Alzheimer's diagnostics and treatments: Seeking alignment on evidence.

Foster NL, Hackett JS, White G, Chenevert S, Svarvar P, Bain L, Carrillo MC.

Alzheimers Dement. 2014 Jul;10(4):503-8. doi: 10.1016/j.jalz.2014.05.003.

PMID: 24985689

 

Coalition Against Major Diseases/European Medicines Agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer's disease.

Hill DL, Schwarz AJ, Isaac M, Pani L, Vamvakas S, Hemmings R, Carrillo MC, Yu P, Sun J, Beckett L, Boccardi M, Brewer J, Brumfield M, Cantillon M, Cole PE, Fox N, Frisoni GB, Jack C, Kelleher T, Luo F, Novak G, Maguire P, Meibach R, Patterson P, Bain L, Sampaio C, Raunig D, Soares H, Suhy J, Wang H, Wolz R, Stephenson D.

Alzheimers Dement. 2014 Jul;10(4):421-9.e3. doi: 10.1016/j.jalz.2013.07.003.

PMID: 24985687

 

Model-based clinical pharmacology profiling of ipilimumab in patients with advanced melanoma.

Feng Y, Masson E, Dai D, Parker SM, Berman D, Roy A.

Br J Clin Pharmacol. 2014 Jul;78(1):106-17. doi: 10.1111/bcp.12323.

PMID: 24433434

 

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Part 1.

Tran TD, Wakenhut F, Pickford C, Shaw S, Westby M, Smith-Burchnell C, Watson L, Paradowski M, Milbank J, Brimage RA, Halstead R, Glen R, Wilson CP, Adam F, Hay D, Chiva JY, Nichols C, Blakemore DC, Gardner I, Dayal S, Pike A, Webster R, Pryde DC.

ChemMedChem. 2014 Jul;9(7):1378-86. doi: 10.1002/cmdc.201400045.

PMID: 24729513

 

Antibody-drug conjugates: current status and future directions.

Perez HL, Cardarelli PM, Deshpande S, Gangwar S, Schroeder GM, Vite GD, Borzilleri RM.

Drug Discov Today. 2014 Jul;19(7):869-81. doi: 10.1016/j.drudis.2013.11.004. Review.

PMID: 24239727

 

[Cost-minimization analysis of subcutaneous abatacept in the treatment of rheumatoid arthritis in Spain].

Ariza R, Van Walsem A, Canal C, Roldán C, Betegón L, Oyagüez I, Janssen K.

Farm Hosp. 2014 Jul 1;38(4):257-65. doi: 10.7399/fh.2014.38.4.1137. Spanish.

PMID: 25137158

 

Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates.

Voronin K, Allentoff AJ, Bonacorsi SJ Jr, Mapelli C, Gong SX, Lee V, Riexinger D, Sanghvi N, Jiang H, Zeng J.

J Labelled Comp Radiopharm. 2014 Jul;57(9):579-83. doi: 10.1002/jlcr.3218.

PMID: 25089024

 

1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity.

Khandelwal P, Stryker S, Chao H, Aranibar N, Lawrence RM, Madireddi M, Zhao W, Chen L, Reily MD.

J Lipid Res. 2014 Jul;55(7):1366-74. doi: 10.1194/jlr.M049155.

PMID: 24755647

 

Patients' perspectives on residual symptoms in bipolar disorder: a focus group study.

Samalin L, Bellivier F, Giordana B, Yon L, Milhiet V, El-Hage W, Courtet P, Hacques E, Bedira N, Dillenschneider A, Llorca PM.

J Nerv Ment Dis. 2014 Jul;202(7):550-5. doi: 10.1097/NMD.0000000000000157.

PMID: 24921420

 

Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors.

Lodge NJ, Li YW, Chin FT, Dischino DD, Zoghbi SS, Deskus JA, Mattson RJ, Imaizumi M, Pieschl R, Molski TF, Fujita M, Dulac H, Zaczek R, Bronson JJ, Macor JE, Innis RB, Pike VW.

Nucl Med Biol. 2014 Jul;41(6):524-35. doi: 10.1016/j.nucmedbio.2014.03.005.

PMID: 24793011

 

Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union.

Annys E, Billington R, Clayton R, Bremm KD, Graziano M, McKelvie J, Ragan I, Schwarz M, van der Laan JW, Wood C, Öberg M, Wester P, Woodward KN.

Regul Toxicol Pharmacol. 2014 Jul;69(2):234-42. doi: 10.1016/j.yrtph.2014.04.009.

PMID: 24768934

 

Information and communication on risks related to medications and proper use of medications for healthcare professionals and the general public: precautionary principle, risk management, communication during and in the absence of crisis situations.

Molimard M, Bernaud C, Lechat P; participants of round table n6 of Giens XXIX: Bejan-Angoulvant Theodora 4 Benattia Cherif 5 Benkritly Amel 6., Bejan-Angoulvant T, Benattia C, Benkritly A, Braunstein D, Cabut S, David N, Fourrier-Réglat A, Gallet B, Gersberg M, Goni S, Jolliet P, Lamarque-Garnier V, Le Jeunne C, Leurs I, Liard F, Malbezin M, Micallef J, Nguon M.

Therapie. 2014 Jul-Aug;69(4):355-66. doi: 10.2515/therapie/2014045. English, French.

PMID: 25099666

 

Information et communication sur les risques liés au médicament et son bon usage auprès des professionnels de santé et du public : principe de précaution, gestion du risque, communication pendant et en dehors des situations de crise.

Molimard M, Bernaud C, Lechat P; et les participants à la table ronde N°6 de Giens XXIX :., Bejan-Angoulvant T, Benattia C, Benkritly A, Braunstein D, Cabut S, David N, Fourrier-Réglat A, Gallet B, Gersberg M, Goni S, Jolliet P, Lamarque-Garnier V, Le Jeunne C, Leurs I, Liard F, Malbezin M, Micallef J, Nguon M.

Therapie. 2014 Jul-Aug;69(4):355-60. doi: 10.2515/therapie/2014044. French. No abstract available.

PMID: 27393228

 

A note on the kappa statistic for clustered dichotomous data.

Zhou M, Yang Z.

Stat Med. 2014 Jun 30;33(14):2425-48. doi: 10.1002/sim.6098.

PMID: 24488927

 

C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma.

Roccaro AM, Sacco A, Jimenez C, Maiso P, Moschetta M, Mishima Y, Aljawai Y, Sahin I, Kuhne M, Cardarelli P, Cohen L, San Miguel JF, Garcia-Sanz R, Ghobrial IM.

Blood. 2014 Jun 26;123(26):4120-31. doi: 10.1182/blood-2014-03-564583.

PMID: 24711662

 

Discovery of daclatasvir, a pan-genotypic hepatitis C virus NS5A replication complex inhibitor with potent clinical effect.

Belema M, Meanwell NA.

J Med Chem. 2014 Jun 26;57(12):5057-71. doi: 10.1021/jm500335h.

PMID: 24749835

 

A bayesian perspective on estimation of variability and uncertainty in mechanism-based models.

Leil TA.

CPT Pharmacometrics Syst Pharmacol. 2014 Jun 25;3:e121. doi: 10.1038/psp.2014.19.

PMID: 24964283

 

Evaluation of 4β-Hydroxycholesterol as a Clinical Biomarker of CYP3A4 Drug Interactions Using a Bayesian Mechanism-Based Pharmacometric Model.

Leil TA, Kasichayanula S, Boulton DW, LaCreta F.

CPT Pharmacometrics Syst Pharmacol. 2014 Jun 25;3:e120. doi: 10.1038/psp.2014.18.

PMID: 24964282

 

Ipilimumab versus placebo after complete resection of stage III melanoma: Initial efficacy and safety results from the EORTC 18071 phase III trial.

Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, Lebbe C, Ferraresi V, Smylie M, Weber JS, Maio M, Konto C, Karra Gurunath R, de Pril V, Suciu S, Testori A.

J Clin Oncol. 2014 Jun 20;32(18_suppl):LBA9008. doi: 10.1200/jco.2014.32.18_suppl.lba9008.

PMID: 28141989

 

Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in advanced melanoma (MEL).

Kluger HM, Callahan MK, Postow MA, Gordon RA, Segal NH, Rizvi NA, Lesokhin AM, Atkins MB, Kirkwood JM, Burke MM, Ralabate AL, Rivera AL, Kronenberg SA, Agunwamba B, Feely W, Hong Q, Krishnan S, Gupta AK, Wolchok JD.

J Clin Oncol. 2014 Jun 20;32(18_suppl):LBA9003. doi: 10.1200/jco.2014.32.18_suppl.lba9003.

PMID: 28141981

 

Sensitive fluorescence-based method for the rapid determination of polysorbate-80 content in therapeutic monoclonal antibody products.

Zheng S, Smith P, Burton L, Adams ML.

Pharm Dev Technol. 2014 Jun 20:1-5. [Epub ahead of print]

PMID: 24946793

 

Serendipitous oxidation product of BIBN4096BS: a potent CGRP receptor antagonist.

Dasgupta B, Kozlowski E, Schroeder DR, Torrente JR, Xu C, Pin S, Conway CM, Dubowchik GM, Macor JE, Vrudhula VM.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2744-8. doi: 10.1016/j.bmcl.2014.04.033.

PMID: 24794104

 

A systematic review and mixed-treatment comparison of dapagliflozin with existing anti-diabetes treatments for those with type 2 diabetes mellitus inadequately controlled by sulfonylurea monotherapy.

Orme M, Fenici P, Lomon ID, Wygant G, Townsend R, Roudaut M.

Diabetol Metab Syndr. 2014 Jun 11;6:73. doi: 10.1186/1758-5996-6-73. Review.

PMID: 25006351

 

Understanding the structure details when drying hydrate crystals of pharmaceuticals - interpretations from diffuse scattering and inter-modulation satellites of a partially dehydrated crystal.

Chan EJ, Gao Q, Dabros M.

Acta Crystallogr B Struct Sci Cryst Eng Mater. 2014 Jun;70(Pt 3):555-67. doi: 10.1107/S2052520614005125.

PMID: 24892602

 

Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.

Lemm JA, Liu M, Gentles RG, Ding M, Voss S, Pelosi LA, Wang YK, Rigat KL, Mosure KW, Bender JA, Knipe JO, Colonno R, Meanwell NA, Kadow JF, Santone KS, Roberts SB, Gao M.

Antimicrob Agents Chemother. 2014 Jun;58(6):3485-95. doi: 10.1128/AAC.02495-13.

PMID: 24733465

 

Randomized, placebo-controlled, single-ascending-dose study of BMS-791325, a hepatitis C virus (HCV) NS5B polymerase inhibitor, in HCV genotype 1 infection.

Sims KD, Lemm J, Eley T, Liu M, Berglind A, Sherman D, Lawitz E, Vutikullird AB, Tebas P, Gao M, Pasquinelli C, Grasela DM.

Antimicrob Agents Chemother. 2014 Jun;58(6):3496-503. doi: 10.1128/AAC.02579-13.

PMID: 24733462

 

Reasons for calibration standard curve slope variation in LC-MS assays and how to address it.

Zhao Y, Liu G, Shen JX, Aubry AF.

Bioanalysis. 2014 Jun;6(11):1439-43. doi: 10.4155/bio.14.71. No abstract available.

PMID: 25046045

 

2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists.

Hu CH, Qiao JX, Han Y, Wang TC, Hua J, Price LA, Wu Q, Shen H, Huang CS, Rehfuss R, Wexler RR, Lam PY.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2481-5. doi: 10.1016/j.bmcl.2014.04.011.

PMID: 24767843

 

Synthesis and structure-activity relationship of dihydrobenzofuran derivatives as novel human GPR119 agonists.

Ye XY, Morales CL, Wang Y, Rossi KA, Malmstrom SE, Abousleiman M, Sereda L, Apedo A, Robl JA, Miller KJ, Krupinski J, Wacker DA.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2539-45. doi: 10.1016/j.bmcl.2014.03.096.

PMID: 24755425

 

Illuminating HIV gp120-Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules.

Parker CG, Dahlgren MK, Tao RN, Li DT, Douglass EF Jr, Shoda T, Jawanda N, Spasov KA, Lee S, Zhou N, Domaoal RA, Sutton RE, Anderson KS, Jorgensen WL, Krystal M, Spiegel DA.

Chem Sci. 2014 Jun 1;5(6):2311-2317.

PMID: 25379167

 

Histologic remission: the ultimate therapeutic goal in ulcerative colitis?

Peyrin-Biroulet L, Bressenot A, Kampman W.

Clin Gastroenterol Hepatol. 2014 Jun;12(6):929-34.e2. doi: 10.1016/j.cgh.2013.07.022. Review.

PMID: 23911875

 

Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus.

Reilly TP, Graziano MJ, Janovitz EB, Dorr TE, Fairchild C, Lee F, Chen J, Wong T, Whaley JM, Tirmenstein M.

Diabetes Ther. 2014 Jun;5(1):73-96. doi: 10.1007/s13300-014-0053-3.

PMID: 24474422

 

Correlating bilayer tablet delamination tendencies to micro-environmental thermodynamic conditions during pan coating.

Zacour BM, Pandey P, Subramanian G, Gao JZ, Nikfar F.

Drug Dev Ind Pharm. 2014 Jun;40(6):829-37. doi: 10.3109/03639045.2013.788014.

PMID: 23638984

 

Effect of symptom severity on efficacy and safety of aripiprazole adjunctive to antidepressant monotherapy in major depressive disorder: a pooled analysis.

Stewart TD, Hatch A, Largay K, Sheehan JJ, Marler SV, Berman RM, Nelson JC.

J Affect Disord. 2014 Jun;162:20-5. doi: 10.1016/j.jad.2014.03.017.

PMID: 24766999

 

Preclinical pharmacokinetics and in vitro metabolism of BMS-605339: a novel HCV NS3 protease inhibitor.

Jenkins S, Scola P, McPhee F, Knipe J, Gesenberg C, Sinz M, Arora V, Pilcher G, Santone K.

J Pharm Sci. 2014 Jun;103(6):1891-902. doi: 10.1002/jps.23959.

PMID: 24700293

 

Longterm safety, efficacy, and inhibition of structural damage progression over 5 years of treatment with abatacept in patients with rheumatoid arthritis in the abatacept in inadequate responders to methotrexate trial.

Kremer JM, Peterfy C, Russell AS, Emery P, Abud-Mendoza C, Sibilia J, Becker JC, Westhovens R, Genant HK.

J Rheumatol. 2014 Jun;41(6):1077-87. doi: 10.3899/jrheum.130263.

PMID: 24786925

 

Pegylated interferons Lambda-1a and alfa-2a display different gene induction and cytokine and chemokine release profiles in whole blood, human hepatocytes and peripheral blood mononuclear cells.

Freeman J, Baglino S, Friborg J, Kraft Z, Gray T, Hill M, McPhee F, Hillson J, Lopez-Talavera JC, Wind-Rotolo M.

J Viral Hepat. 2014 Jun;21(6):e1-9. doi: 10.1111/jvh.12243.

PMID: 24827902

 

Severe infusion reactions to cetuximab occur within 1 h in patients with metastatic colorectal cancer: results of a nationwide, multicenter, prospective registry study of 2126 patients in Japan.

Yamaguchi K, Watanabe T, Satoh T, Ishiguro M, Izawa M, Inoshiri S, Sugihara K, Sakata Y.

Jpn J Clin Oncol. 2014 Jun;44(6):541-6. doi: 10.1093/jjco/hyu049.

PMID: 24771864

 

Exenatide once weekly versus insulin glargine for type 2 diabetes (DURATION-3): 3-year results of an open-label randomised trial.

Diamant M, Van Gaal L, Guerci B, Stranks S, Han J, Malloy J, Boardman MK, Trautmann ME.

Lancet Diabetes Endocrinol. 2014 Jun;2(6):464-73. doi: 10.1016/S2213-8587(14)70029-4. Erratum in: Lancet Diabetes Endocrinol. 2014 Jun;2(6):e13.

PMID: 24731672

 

Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial.

Kwon ED, Drake CG, Scher HI, Fizazi K, Bossi A, van den Eertwegh AJ, Krainer M, Houede N, Santos R, Mahammedi H, Ng S, Maio M, Franke FA, Sundar S, Agarwal N, Bergman AM, Ciuleanu TE, Korbenfeld E, Sengeløv L, Hansen S, Logothetis C, Beer TM, McHenry MB, Gagnier P, Liu D, Gerritsen WR; CA184-043 Investigators..

Lancet Oncol. 2014 Jun;15(7):700-12. doi: 10.1016/S1470-2045(14)70189-5.

PMID: 24831977

 

Significance of unfolding thermodynamics for predicting aggregation kinetics: a case study on high concentration solutions of a multi-domain protein.

Saluja A, Sadineni V, Mungikar A, Nashine V, Kroetsch A, Dahlheim C, Rao VM.

Pharm Res. 2014 Jun;31(6):1575-87. doi: 10.1007/s11095-013-1263-5.

PMID: 24398696

 

Evaluation of safety and tolerability, pharmacokinetics, and pharmacodynamics of BMS-820836 in healthy subjects: a placebo-controlled, ascending single-dose study.

Risinger R, Bhagwagar Z, Luo F, Cahir M, Miler L, Mendonza AE, Meyer JH, Zheng M, Hayes W.

Psychopharmacology (Berl). 2014 Jun;231(11):2299-310. doi: 10.1007/s00213-013-3391-3.

PMID: 24337079

 

The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: study design, data analysis, interpretation.

Lebrec H, Molinier B, Boverhof D, Collinge M, Freebern W, Henson K, Mytych DT, Ochs HD, Wange R, Yang Y, Zhou L, Arrington J, Christin-Piché MS, Shenton J.

Regul Toxicol Pharmacol. 2014 Jun;69(1):7-21. doi: 10.1016/j.yrtph.2014.02.008. Review.

PMID: 24566336

 

The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies.

Pettersen JC, Litchfield J, Neef N, Schmidt SP, Shirai N, Walters KM, Enerson BE, Chatman LA, Pfefferkorn JA.

Toxicol Pathol. 2014 Jun;42(4):696-708. doi: 10.1177/0192623314526006.

PMID: 24771080

 

Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin: The ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation): Predictors, Characteristics, and Clinical Outcomes.

Hylek EM, Held C, Alexander JH, Lopes RD, De Caterina R, Wojdyla DM, Huber K, Jansky P, Steg PG, Hanna M, Thomas L, Wallentin L, Granger CB.

J Am Coll Cardiol. 2014 May 27;63(20):2141-7. doi: 10.1016/j.jacc.2014.02.549.

PMID: 24657685

 

Genetic regulation of mouse liver metabolite levels.

Ghazalpour A, Bennett BJ, Shih D, Che N, Orozco L, Pan C, Hagopian R, He A, Kayne P, Yang WP, Kirchgessner T, Lusis AJ.

Mol Syst Biol. 2014 May 23;10:730. doi: 10.15252/msb.20135004.

PMID: 24860088

 

Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).

Li J, Kennedy LJ, Wang H, Li JJ, Walker SJ, Hong Z, O'Connor SP, Nayeem A, Camac DM, Morin PE, Sheriff S, Wang M, Harper T, Golla R, Seethala R, Harrity T, Ponticiello RP, Morgan NN, Taylor JR, Zebo R, Gordon DA, Robl JA.

ACS Med Chem Lett. 2014 May 22;5(7):803-8. doi: 10.1021/ml500144h.

PMID: 25050169

 

Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.

Liu S, Zha C, Nacro K, Hu M, Cui W, Yang YL, Bhatt U, Sambandam A, Isherwood M, Yet L, Herr MT, Ebeltoft S, Hassler C, Fleming L, Pechulis AD, Payen-Fornicola A, Holman N, Milanowski D, Cotterill I, Mozhaev V, Khmelnitsky Y, Guzzo PR, Sargent BJ, Molino BF, Olson R, King D, Lelas S, Li YW, Johnson K, Molski T, Orie A, Ng A, Haskell R, Clarke W, Bertekap R, O'Connell J, Lodge N, Sinz M, Adams S, Zaczek R, Macor JE.

ACS Med Chem Lett. 2014 May 13;5(7):760-5. doi: 10.1021/ml500053b.

PMID: 25050161

 

Development and validation of a clinical scoring system for predicting risk of HCC in asymptomatic individuals seropositive for anti-HCV antibodies.

Lee MH, Lu SN, Yuan Y, Yang HI, Jen CL, You SL, Wang LY, L'Italien G, Chen CJ; R.E.V.E.A.L.-HCV Study Group..

PLoS One. 2014 May 6;9(5):e94760. doi: 10.1371/journal.pone.0094760.

PMID: 24801353

 

Analysis of L-serine-O-phosphate in cerebrospinal spinal fluid by derivatization-liquid chromatography/mass spectrometry.

McNaney CA, Benitex Y, Luchetti D, Labasi JM, Olah TV, Morgan DG, Drexler DM.

Anal Biochem. 2014 May 1;452:10-2. doi: 10.1016/j.ab.2014.02.007.

PMID: 24534252

 

Development of other microtubule-stabilizer families: the epothilones and their derivatives.

Brogdon CF, Lee FY, Canetta RM.

Anticancer Drugs. 2014 May;25(5):599-609. doi: 10.1097/CAD.0000000000000071. Review.

PMID: 24398663

 

Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.

Shi Q, Tebben A, Dyckman AJ, Li H, Liu C, Lin J, Spergel S, Burke JR, McIntyre KW, Olini GC, Strnad J, Surti N, Muckelbauer JK, Chang C, An Y, Cheng L, Ruan Q, Leftheris K, Carter PH, Tino J, De Lucca GV.

Bioorg Med Chem Lett. 2014 May 1;24(9):2206-11. doi: 10.1016/j.bmcl.2014.02.075.

PMID: 24685542

 

Nonclinical Safety Profile of BMS-986001, a Nucleoside Transcriptase Inhibitor for Combination Retroviral Therapy.

Mausumee G, Frank S, Shawn C, Dara H, Zhao Y, Soleil PM, Sanderson TP, Michael G, Marc D.

Int J Toxicol. 2014 May;33(3):204-218.

PMID: 24846376

 

Utility of population pharmacokinetic modeling in the assessment of therapeutic protein-drug interactions.

Chow AT, Earp JC, Gupta M, Hanley W, Hu C, Wang DD, Zajic S, Zhu M; Population PK TPDI Working Group..

J Clin Pharmacol. 2014 May;54(5):593-601. doi: 10.1002/jcph.240.

PMID: 24272952

 

A comprehensive review of the pharmacokinetics of approved therapeutic monoclonal antibodies in Japan: Are Japanese phase I studies still needed?

Chiba K, Yoshitsugu H, Kyosaka Y, Iida S, Yoneyama K, Tanigawa T, Fukushima T, Hiraoka M.

J Clin Pharmacol. 2014 May;54(5):483-94. doi: 10.1002/jcph.231. Review.

PMID: 24242979

 

Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.

Xie JH, Yamniuk AP, Borowski V, Kuhn R, Susulic V, Rex-Rabe S, Yang X, Zhou X, Zhang Y, Gillooly K, Brosius R, Ravishankar R, Waggie K, Mink K, Price L, Rehfuss R, Tamura J, An Y, Cheng L, Abramczyk B, Ignatovich O, Drew P, Grant S, Bryson JW, Suchard S, Salter-Cid L, Nadler S, Suri A.

J Immunol. 2014 May 1;192(9):4083-92. doi: 10.4049/jimmunol.1303239.

PMID: 24670803

 

Incompatibility of croscarmellose sodium with alkaline excipients in a tablet formulation.

Bindra DS, Stein D, Pandey P, Barbour N.

Pharm Dev Technol. 2014 May;19(3):285-9. doi: 10.3109/10837450.2013.778869.

PMID: 23528069

 

Estimated hospitalizations attributable to diabetes mellitus within the public healthcare system in Brazil from 2008 to 2010: study DIAPS 79.

Rosa R, Nita ME, Rached R, Donato B, Rahal E.

Rev Assoc Med Bras (1992). 2014 May-Jun;60(3):222-30.

PMID: 25004267

 

The economic burden of posttransplant events in renal transplant recipients in Europe.

Chamberlain G, Baboolal K, Bennett H, Pockett RD, McEwan P, Sabater J, Sennfält K.

Transplantation. 2014 Apr 27;97(8):854-61. doi: 10.1097/01.TP.0000438205.04348.69.

PMID: 24732898

 

Application of imaging based tools for the characterisation of hollow spray dried amorphous dispersion particles.

Gamble JF, Ferreira AP, Tobyn M, DiMemmo L, Martin K, Mathias N, Schild R, Vig B, Baumann JM, Parks S, Ashton M.

Int J Pharm. 2014 Apr 25;465(1-2):210-7. doi: 10.1016/j.ijpharm.2014.02.002.

PMID: 24508807

 

Preventable coronary heart disease events from control of cardiovascular risk factors in US adults with diabetes (projections from utilizing the UKPDS risk engine).

Wong ND, Patao C, Malik S, Iloeje U.

Am J Cardiol. 2014 Apr 15;113(8):1356-61. doi: 10.1016/j.amjcard.2013.12.042.

PMID: 24581920

 

Optimization and simulation of tandem column supercritical fluid chromatography separations using column back pressure as a unique parameter.

Wang C, Tymiak AA, Zhang Y.

Anal Chem. 2014 Apr 15;86(8):4033-40. doi: 10.1021/ac500530n.

PMID: 24661124

 

Identification of a novel series of potent HCV NS5B Site I inhibitors.

Eastman KJ, Yang Z, Bender JA, Mosure K, Lemm JA, Meanwell NA, Roberts SB, Knipe J, Kadow JF.

Bioorg Med Chem Lett. 2014 Apr 15;24(8):1993-7. doi: 10.1016/j.bmcl.2014.02.047.

PMID: 24656612

 

Simultaneous quantification of the glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK) receptor agonists in rodent plasma by on-line solid phase extraction and LC-MS/MS.

Wang Y, Roth JD, Taylor SW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:24-9. doi: 10.1016/j.jchromb.2014.02.040. Erratum in: J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jul 15;963:141-2.

PMID: 24657407

 

Feasibility assessment of a novel selective peptide derivatization strategy for sensitivity enhancement for the liquid chromatography/tandem mass spectrometry bioanalysis of protein therapeutics in serum.

Yuan L, Mai A, Aubry AF, Arnold ME, Ji QC.

Rapid Commun Mass Spectrom. 2014 Apr 15;28(7):705-12. doi: 10.1002/rcm.6836.

PMID: 24573801

 

Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling.

Nakamura I, Zakharia K, Banini BA, Mikhail DS, Kim TH, Yang JD, Moser CD, Shaleh HM, Thornburgh SR, Walters I, Roberts LR.

PLoS One. 2014 Apr 7;9(4):e92273. doi: 10.1371/journal.pone.0092273. Erratum in: PLoS One. 2015;10(11):e0142355.

PMID: 24710173

  

 Multiple myeloma in the very old: an IASIA conference report.

Tuchman SA, Shapiro GR, Ershler WB, Badros A, Cohen HJ, Dispenzieri A, Flores IQ, Kanapuru B, Jurivich D, Longo DL, Nourbakhsh A, Palumbo A, Walston J, Yates JW.

J Natl Cancer Inst. 2014 Apr 3;106(5). pii: dju067. doi: 10.1093/jnci/dju067.

PMID: 24700806

 

From bench to humans: formulation development of a poorly water soluble drug to mitigate food effect.

Pandey P, Hamey R, Bindra DS, Huang Z, Mathias N, Eley T, Crison J, Yan B, Perrone R, Vemavarapu C.

AAPS PharmSciTech. 2014 Apr;15(2):407-16. doi: 10.1208/s12249-013-0069-4.

PMID: 24442773

 

Influence of process parameters on tablet bed microenvironmental factors during pan coating.

Pandey P, Bindra DS, Felton LA.

AAPS PharmSciTech. 2014 Apr;15(2):296-305. doi: 10.1208/s12249-013-0060-0.

PMID: 24323824

 

Effect of activated charcoal on apixaban pharmacokinetics in healthy subjects.

Wang X, Mondal S, Wang J, Tirucherai G, Zhang D, Boyd RA, Frost C.

Am J Cardiovasc Drugs. 2014 Apr;14(2):147-54. doi: 10.1007/s40256-013-0055-y.

PMID: 24277644

 

Measuring biotherapeutics with endogenous counterparts and pre-existing antibodies: an interferon case study.

Myler H, Felix T, Zhu J, Hruska M, Piccoli SP.

Bioanalysis. 2014 Apr;6(8):1113-22. doi: 10.4155/bio.14.37.

PMID: 24830895

 

Addressing matrix effects in ligand-binding assays through the use of new reagents and technology.

Chilewski SD, Mora JR, Gleason C, DeSilva B.

Bioanalysis. 2014 Apr;6(8):1059-67. doi: 10.4155/bio.14.75.

PMID: 24830890

 

Matrix interference in ligand-binding assays: challenge or solution?

DeSilva B, Garofolo F.

Bioanalysis. 2014 Apr;6(8):1029-31. doi: 10.4155/bio.14.92. No abstract available.

PMID: 24830884

 

Conjugated critical reagent characterization for ligand-binding assays: using MALDI-TOF-MS as an orthogonal tool to assess assay performance.

Haulenbeek J, Piccoli SP.

Bioanalysis. 2014 Apr;6(7):983-92. doi: 10.4155/bio.14.65. Review.

PMID: 24806906

 

Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Mo R, Yang MG, Xiao Z, Zhao Q, Mandlekar S, Cvijic ME, Charo IF, Barrish JC, Decicco CP, Carter PH.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1843-5. doi: 10.1016/j.bmcl.2014.02.013.

PMID: 24613378

 

Cytokine release assays: current practices and future directions.

Finco D, Grimaldi C, Fort M, Walker M, Kiessling A, Wolf B, Salcedo T, Faggioni R, Schneider A, Ibraghimov A, Scesney S, Serna D, Prell R, Stebbings R, Narayanan PK.

Cytokine. 2014 Apr;66(2):143-55. doi: 10.1016/j.cyto.2013.12.009. Review.

PMID: 24412476

 

Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies.

Chadwick KD, Fletcher AM, Parrula MC, Bonner-Weir S, Mangipudy RS, Janovitz E, Graziano MJ, Roy D, Reilly TP.

Diabetes. 2014 Apr;63(4):1303-14. doi: 10.2337/db13-1268.

PMID: 24222349

 

Understanding the thermodynamic micro-environment inside a pan coater using a data logging device.

Pandey P, Ji J, Subramanian G, Gour S, Bindra DS.

Drug Dev Ind Pharm. 2014 Apr;40(4):542-8. doi: 10.3109/03639045.2013.772192.

PMID: 23590129

 

Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump.

Rodrigues AD, Lai Y, Cvijic ME, Elkin LL, Zvyaga T, Soars MG.

Drug Metab Dispos. 2014 Apr;42(4):566-74. doi: 10.1124/dmd.113.054205. Review. Erratum in: Drug Metab Dispos. 2014 Nov;42(11):1978.

PMID: 24115749

 

Residual symptoms and functional performance in a large sample of euthymic bipolar patients in France (the OPTHYMUM study).

Samalin L, Llorca PM, Giordana B, Milhiet V, Yon L, El-Hage W, Courtet P, Hacques E, Bedira N, Filipovics A, Arnaud R, Dillenschneider A, Bellivier F.

J Affect Disord. 2014 Apr;159:94-102. doi: 10.1016/j.jad.2014.02.023.

PMID: 24679396

 

Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity.

Appiah KK, Blat Y, Robertson BJ, Pearce BC, Pedicord DL, Gentles RG, Yu XC, Mseeh F, Nguyen N, Swaffield JC, Harden DG, Westphal RS, Banks MN, O'Connell JC.

J Biomol Screen. 2014 Apr;19(4):595-605. doi: 10.1177/1087057113511111.

PMID: 24241710

 

Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab.

Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, Brahmer JR, Lawrence DP, Atkins MB, Powderly JD, Leming PD, Lipson EJ, Puzanov I, Smith DC, Taube JM, Wigginton JM, Kollia GD, Gupta A, Pardoll DM, Sosman JA, Hodi FS.

J Clin Oncol. 2014 Apr 1;32(10):1020-30. doi: 10.1200/JCO.2013.53.0105.

PMID: 24590637

 

Switching of biologic disease modifying anti-rheumatic drugs in patients with rheumatoid arthritis in a real world setting.

Meissner B, Trivedi D, You M, Rosenblatt L.

J Med Econ. 2014 Apr;17(4):259-65. doi: 10.3111/13696998.2014.893241.

PMID: 24575891

 

In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10).

Brown JM, Hunihan L, Prack MM, Harden DG, Bronson J, Dzierba CD, Gentles RG, Hendricson A, Krause R, Macor JE, Westphal RS.

J Neurochem. 2014 Apr;129(2):275-83. doi: 10.1111/jnc.12618.

PMID: 24266811

 

Determination of 2-Hydroxypyridine-1-Oxide (HOPO) at sub-ppm levels using derivitization and gas chromatography with mass spectrometry detection (GCMS).

Quirk E, Davies C, Foy P, Bretnall A, Clarke GS.

J Pharm Biomed Anal. 2014 Apr;92:127-34. doi: 10.1016/j.jpba.2014.01.009.

PMID: 24525561

 

Subcutaneous abatacept for the treatment of rheumatoid arthritis: longterm data from the ACQUIRE trial.

Genovese MC, Tena CP, Covarrubias A, Leon G, Mysler E, Keiserman M, Valente R, Nash P, Simon-Campos JA, Box J, Legerton CW 3rd, Nasonov E, Durez P, Delaet I, Teng J, Alten R.

J Rheumatol. 2014 Apr;41(4):629-39. doi: 10.3899/jrheum.130112.

PMID: 24584926

 

Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control.

Kohan DE, Fioretto P, Tang W, List JF.

Kidney Int. 2014 Apr;85(4):962-71. doi: 10.1038/ki.2013.356.

PMID: 24067431

 

Efficacy and safety of apixaban in patients after cardioversion for atrial fibrillation: insights from the ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation).

Flaker G, Lopes RD, Al-Khatib SM, Hermosillo AG, Hohnloser SH, Tinga B, Zhu J, Mohan P, Garcia D, Bartunek J, Vinereanu D, Husted S, Harjola VP, Rosenqvist M, Alexander JH, Granger CB; ARISTOTLE Committees and Investigators..

J Am Coll Cardiol. 2014 Mar 25;63(11):1082-7. doi: 10.1016/j.jacc.2013.09.062.

PMID: 24211508

 

Discovery of a cyclopentylamine as an orally active dual NK1 receptor antagonist-serotonin reuptake transporter inhibitor.

Wu YJ, He H, Gao Q, Wu D, Bertekap R, Westphal RS, Lelas S, Newton A, Wallace T, Taber M, Davis C, Macor JE, Bronson J.

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1611-4. doi: 10.1016/j.bmcl.2014.01.036.

PMID: 24507922

 

Discovery and development of hepatitis C virus NS5A replication complex inhibitors.

Belema M, Lopez OD, Bender JA, Romine JL, St Laurent DR, Langley DR, Lemm JA, O'Boyle DR 2nd, Sun JH, Wang C, Fridell RA, Meanwell NA.

J Med Chem. 2014 Mar 13;57(5):1643-72. doi: 10.1021/jm401793m.

PMID: 24621191

 

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.

Scola PM, Sun LQ, Wang AX, Chen J, Sin N, Venables BL, Sit SY, Chen Y, Cocuzza A, Bilder DM, D'Andrea SV, Zheng B, Hewawasam P, Tu Y, Friborg J, Falk P, Hernandez D, Levine S, Chen C, Yu F, Sheaffer AK, Zhai G, Barry D, Knipe JO, Han YH, Schartman R, Donoso M, Mosure K, Sinz MW, Zvyaga T, Good AC, Rajamani R, Kish K, Tredup J, Klei HE, Gao Q, Mueller L, Colonno RJ, Grasela DM, Adams SP, Loy J, Levesque PC, Sun H, Shi H, Sun L, Warner W, Li D, Zhu J, Meanwell NA, McPhee F.

J Med Chem. 2014 Mar 13;57(5):1730-52. doi: 10.1021/jm500297k.

PMID: 24564672

 

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

Scola PM, Wang AX, Good AC, Sun LQ, Combrink KD, Campbell JA, Chen J, Tu Y, Sin N, Venables BL, Sit SY, Chen Y, Cocuzza A, Bilder DM, D'Andrea S, Zheng B, Hewawasam P, Ding M, Thuring J, Li J, Hernandez D, Yu F, Falk P, Zhai G, Sheaffer AK, Chen C, Lee MS, Barry D, Knipe JO, Li W, Han YH, Jenkins S, Gesenberg C, Gao Q, Sinz MW, Santone KS, Zvyaga T, Rajamani R, Klei HE, Colonno RJ, Grasela DM, Hughes E, Chien C, Adams S, Levesque PC, Li D, Zhu J, Meanwell NA, McPhee F.

J Med Chem. 2014 Mar 13;57(5):1708-29. doi: 10.1021/jm401840s.

PMID: 24555570

 

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

Belema M, Nguyen VN, Bachand C, Deon DH, Goodrich JT, James CA, Lavoie R, Lopez OD, Martel A, Romine JL, Ruediger EH, Snyder LB, St Laurent DR, Yang F, Zhu J, Wong HS, Langley DR, Adams SP, Cantor GH, Chimalakonda A, Fura A, Johnson BM, Knipe JO, Parker DD, Santone KS, Fridell RA, Lemm JA, O'Boyle DR 2nd, Colonno RJ, Gao M, Meanwell NA, Hamann LG.

J Med Chem. 2014 Mar 13;57(5):2013-32. doi: 10.1021/jm401836p.

PMID: 24521299

 

Introduction to hepatitis C virus (HCV) therapies special thematic issue.

Meanwell NA, Watkins WJ.

J Med Chem. 2014 Mar 13;57(5):1625-6. doi: 10.1021/jm5000936. No abstract available.

PMID: 24484173

 

Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons.

Belema M, Nguyen VN, Romine JL, St Laurent DR, Lopez OD, Goodrich JT, Nower PT, O'Boyle DR 2nd, Lemm JA, Fridell RA, Gao M, Fang H, Krause RG, Wang YK, Oliver AJ, Good AC, Knipe JO, Meanwell NA, Snyder LB.

J Med Chem. 2014 Mar 13;57(5):1995-2012. doi: 10.1021/jm4016203.

PMID: 24437689

 

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Gentles RG, Ding M, Bender JA, Bergstrom CP, Grant-Young K, Hewawasam P, Hudyma T, Martin S, Nickel A, Regueiro-Ren A, Tu Y, Yang Z, Yeung KS, Zheng X, Chao S, Sun JH, Beno BR, Camac DM, Chang CH, Gao M, Morin PE, Sheriff S, Tredup J, Wan J, Witmer MR, Xie D, Hanumegowda U, Knipe J, Mosure K, Santone KS, Parker DD, Zhuo X, Lemm J, Liu M, Pelosi L, Rigat K, Voss S, Wang Y, Wang YK, Colonno RJ, Gao M, Roberts SB, Gao Q, Ng A, Meanwell NA, Kadow JF.

J Med Chem. 2014 Mar 13;57(5):1855-79. doi: 10.1021/jm4016894.

PMID: 24397558

 

HCV NS5A replication complex inhibitors. Part 4. Optimization for genotype 1a replicon inhibitory activity.

St Laurent DR, Serrano-Wu MH, Belema M, Ding M, Fang H, Gao M, Goodrich JT, Krause RG, Lemm JA, Liu M, Lopez OD, Nguyen VN, Nower PT, O'Boyle DR 2nd, Pearce BC, Romine JL, Valera L, Sun JH, Wang YK, Yang F, Yang X, Meanwell NA, Snyder LB.

J Med Chem. 2014 Mar 13;57(5):1976-94. doi: 10.1021/jm301796k.

PMID: 23573957

 

Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β.

Toyn JH, Ahlijanian MK.

Alzheimers Res Ther. 2014 Mar 12;6(2):14. doi: 10.1186/alzrt244. Review.

PMID: 25031632

 

Comparative assessment of achiral stationary phases for high throughput analysis in supercritical fluid chromatography.

Ebinger K, Weller HN.

J Chromatogr A. 2014 Mar 7;1332:73-81. doi: 10.1016/j.chroma.2014.01.060.

PMID: 24508356

 

Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.

Jiang H, Xu W, Titsch CA, Furlong MT, Dodge R, Voronin K, Allentoff A, Zeng J, Aubry AF, DeSilva BS, Arnold ME.

Anal Chem. 2014 Mar 4;86(5):2673-80. doi: 10.1021/ac5001465.

PMID: 24506335

 

Application and challenges in using LC-MS assays for absolute quantitative analysis of therapeutic proteins in drug discovery.

Zheng J, Mehl J, Zhu Y, Xin B, Olah T.

Bioanalysis. 2014 Mar;6(6):859-79. doi: 10.4155/bio.14.36. Review.

PMID: 24702115

 

Reflecting on a decade of metabolite screening and monitoring.

Aubry AF, Christopher LJ, Wang J, Zhu M, Tirucherai G, Arnold ME.

Bioanalysis. 2014 Mar;6(5):651-64. doi: 10.4155/bio.14.19. Review.

PMID: 24620807

 

Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists.

Hu S, Huang Y, Wu YJ, He H, Grant-Young KA, Bertekap RL, Whiterock V, Brassil P, Lentz K, Sivaprakasam P, Langley DR, Westphal RS, Scola PM.

Bioorg Med Chem. 2014 Mar 1;22(5):1782-90. doi: 10.1016/j.bmc.2014.01.003.

PMID: 24495863

 

Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.

Jeon YT, Yang W, Qiao JX, Li L, Ruel R, Thibeault C, Hiebert S, Wang TC, Wang Y, Liu Y, Clark CG, Wong HS, Zhu J, Wu DR, Sun D, Chen BC, Mathur A, Chacko SA, Malley M, Chen XQ, Shen H, Huang CS, Schumacher WA, Bostwick JS, Stewart AB, Price LA, Hua J, Li D, Levesque PC, Seiffert DA, Rehfuss R, Wexler RR, Lam PY.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1294-8. doi: 10.1016/j.bmcl.2014.01.066.

PMID: 24513044

 

Genital and urinary tract infections in diabetes: impact of pharmacologically-induced glucosuria.

Geerlings S, Fonseca V, Castro-Diaz D, List J, Parikh S.

Diabetes Res Clin Pract. 2014 Mar;103(3):373-81. doi: 10.1016/j.diabres.2013.12.052. Review.

PMID: 24529566

 

Evaluation of the relationship between weight change and glycemic control after initiation of antidiabetic therapy in patients with type 2 diabetes using electronic medical record data.

McAdam-Marx C, Mukherjee J, Bellows BK, Unni S, Ye X, Iloeje U, Brixner DI.

Diabetes Res Clin Pract. 2014 Mar;103(3):402-11. doi: 10.1016/j.diabres.2013.12.038.

PMID: 24503045

 

Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system.

Selvakumar S, Bhutani P, Ghosh K, Krishnamurthy P, Kallipatti S, Selvam S, Ramarao M, Mandlekar S, Sinz MW, Rodrigues AD, Subramanian M.

Drug Metab Dispos. 2014 Mar;42(3):369-76. doi: 10.1124/dmd.113.055491.

PMID: 24335510

 

On the "proportion eliminated" for risk differences versus excess relative risks.

Suzuki E, Evans D, Chaix B, Vanderweele TJ.

Epidemiology. 2014 Mar;25(2):309-10. doi: 10.1097/EDE.0000000000000060. No abstract available.

PMID: 24487217

 

Commentary: Socioeconomic status, health behavior, and mortality: old question plus modern methods equals new insights?

Chaix B, Evans D, Suzuki E.

Epidemiology. 2014 Mar;25(2):178-81. doi: 10.1097/EDE.0000000000000062. No abstract available.

PMID: 24487201

 

Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach.

McIntyre RS, Filteau MJ, Martin L, Patry S, Carvalho A, Cha DS, Barakat M, Miguelez M.

J Affect Disord. 2014 Mar;156:1-7. doi: 10.1016/j.jad.2013.10.043. Review.

PMID: 24314926

 

Genotypic correlates of susceptibility to HIV-1 attachment inhibitor BMS-626529, the active agent of the prodrug BMS-663068.

Zhou N, Nowicka-Sans B, McAuliffe B, Ray N, Eggers B, Fang H, Fan L, Healy M, Langley DR, Hwang C, Lataillade M, Hanna GJ, Krystal M.

J Antimicrob Chemother. 2014 Mar;69(3):573-81. doi: 10.1093/jac/dkt412.

PMID: 24128669

 

Disease and treatment perceptions among Asian Americans diagnosed with chronic hepatitis B infection.

Tokes K, Quadri S, Cahill P, Chiu G, Ivanov A, Tang H.

J Gen Intern Med. 2014 Mar;29(3):477-84. doi: 10.1007/s11606-013-2673-0.

PMID: 24352635

 

Randomized trial of daclatasvir and asunaprevir with or without PegIFN/RBV for hepatitis C virus genotype 1 null responders.

Lok AS, Gardiner DF, Hézode C, Lawitz EJ, Bourlière M, Everson GT, Marcellin P, Rodriguez-Torres M, Pol S, Serfaty L, Eley T, Huang SP, Li J, Wind-Rotolo M, Yu F, McPhee F, Grasela DM, Pasquinelli C.

J Hepatol. 2014 Mar;60(3):490-9. doi: 10.1016/j.jhep.2013.10.019.

PMID: 24444658

 

The synthesis of (14)C-labeled, (13)CD2-labeled saxagliptin, and its (13)CD2-labeled 5-hydroxy metabolite.

Tran SB, Maxwell BD, Cao K, Bonacorsi SJ.

J Labelled Comp Radiopharm. 2014 Mar;57(3):136-40. doi: 10.1002/jlcr.3179.

PMID: 24519575

 

Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity.

Desai D, Wong B, Huang Y, Ye Q, Tang D, Guo H, Huang M, Timmins P.

J Pharm Sci. 2014 Mar;103(3):920-6. doi: 10.1002/jps.23852.

PMID: 24549733

 

Assessing the impact of propensity score estimation and implementation on covariate balance and confounding control within and across important subgroups in comparative effectiveness research.

Girman CJ, Gokhale M, Kou TD, Brodovicz KG, Wyss R, Stürmer T.

Med Care. 2014 Mar;52(3):280-7. doi: 10.1097/MLR.0000000000000064.

PMID: 24374422

 

Projecting long-term graft and patient survival after transplantation.

Levy AR, Briggs AH, Johnston K, MacLean JR, Yuan Y, L'Italien GJ, Kalsekar A, Schnitzler MA.

Value Health. 2014 Mar;17(2):254-60. doi: 10.1016/j.jval.2014.01.001.

PMID: 24636384

 

Dynamic changes in myocardial matrix and relevance to disease: translational perspectives.

Li AH, Liu PP, Villarreal FJ, Garcia RA.

Circ Res. 2014 Feb 28;114(5):916-27. doi: 10.1161/CIRCRESAHA.114.302819. Review.

PMID: 24577970

 

Meta-analysis of peripheral blood apolipoprotein E levels in Alzheimer's disease.

Wang C, Yu JT, Wang HF, Jiang T, Tan CC, Meng XF, Soares HD, Tan L.

PLoS One. 2014 Feb 18;9(2):e89041. doi: 10.1371/journal.pone.0089041.

PMID: 24558469

 

Chemical structure informing statistical hypothesis testing in metabolomics.

Zhu H, Luo M.

Bioinformatics. 2014 Feb 15;30(4):514-22. doi: 10.1093/bioinformatics/btt708.

PMID: 24319000

 

Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors.

Quan ML, Wong PC, Wang C, Woerner F, Smallheer JM, Barbera FA, Bozarth JM, Brown RL, Harpel MR, Luettgen JM, Morin PE, Peterson T, Ramamurthy V, Rendina AR, Rossi KA, Watson CA, Wei A, Zhang G, Seiffert D, Wexler RR.

J Med Chem. 2014 Feb 13;57(3):955-69. doi: 10.1021/jm401670x.

PMID: 24405333

 

High-sensitivity troponin I for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.

Hijazi Z, Siegbahn A, Andersson U, Granger CB, Alexander JH, Atar D, Gersh BJ, Mohan P, Harjola VP, Horowitz J, Husted S, Hylek EM, Lopes RD, McMurray JJ, Wallentin L; ARISTOTLE Investigators..

Circulation. 2014 Feb 11;129(6):625-34. doi: 10.1161/CIRCULATIONAHA.113.006286.

PMID: 24226808

 

Establishing a High-content Analysis Method for Tubulin Polymerization to Evaluate Both the Stabilizing and Destabilizing Activities of Compounds.

Sum CS, Nickischer D, Lei M, Weston A, Zhang L, Schweizer L.

Curr Chem Genom Transl Med. 2014 Feb 7;8(Suppl 1):16-26. doi: 10.2174/2213988501408010016.

PMID: 24596681

 

Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer.

Jonker DJ, Karapetis CS, Harbison C, O'Callaghan CJ, Tu D, Simes RJ, Malone DP, Langer C, Tebbutt N, Price TJ, Shapiro J, Siu LL, Wong RP, Bjarnason G, Moore MJ, Zalcberg JR, Khambata-Ford S.

Br J Cancer. 2014 Feb 4;110(3):648-55. doi: 10.1038/bjc.2013.753.

PMID: 24335920

 

Assessment of the cardiovascular safety of saxagliptin in patients with type 2 diabetes mellitus: pooled analysis of 20 clinical trials.

Iqbal N, Parker A, Frederich R, Donovan M, Hirshberg B.

Cardiovasc Diabetol. 2014 Feb 4;13:33. doi: 10.1186/1475-2840-13-33.

PMID: 24490835

 

Estimation of the unbound brain concentration of P-glycoprotein substrates or nonsubstrates by a serial cerebrospinal fluid sampling technique in rats.

Mariappan TT, Kurawattimath V, Gautam SS, Kulkarni CP, Kallem R, Taskar KS, Marathe PH, Mandlekar S.

Mol Pharm. 2014 Feb 3;11(2):477-85. doi: 10.1021/mp400436d.

PMID: 24380373

 

The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.

Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):173-81. doi: 10.1107/S2053230X14000144.

PMID: 24637750

 

Targeting epigenetic regulators for cancer therapy.

Wee S, Dhanak D, Li H, Armstrong SA, Copeland RA, Sims R, Baylin SB, Liu XS, Schweizer L.

Ann N Y Acad Sci. 2014 Feb;1309:30-6. doi: 10.1111/nyas.12356. Review.

PMID: 24571255

 

Sensitivity-based analytical approaches to support human absolute bioavailability studies.

Xu XS, Jiang H, Christopher LJ, Shen JX, Zeng J, Arnold ME.

Bioanalysis. 2014 Feb;6(4):497-504. doi: 10.4155/bio.13.318.

PMID: 24568352

 

Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation.

Riehle KJ, Johnson MM, Johansson F, Bauer RL, Hayes BJ, Gilbertson DG, Haran AC, Fausto N, Campbell JS.

Biochim Biophys Acta. 2014 Feb;1842(2):318-25. doi: 10.1016/j.bbadis.2013.11.013.

PMID: 24269585

 

Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors.

Wang Y, Yang W, Finlay HJ, Harikrishnan LS, Jiang J, Kamau MG, Van Kirk K, Nirschl DS, Taylor DS, Chen AY, Yin X, Sleph PG, Yang RZ, Huang CS, Adam LP, Lawrence RM, Wexler RR, Salvati ME.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):860-4. doi: 10.1016/j.bmcl.2013.12.088.

PMID: 24424134

 

Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERα(+) tumorigenesis.

Chan SR, Rickert CG, Vermi W, Sheehan KC, Arthur C, Allen JA, White JM, Archambault J, Lonardi S, McDevitt TM, Bhattacharya D, Lorenzi MV, Allred DC, Schreiber RD.

Cell Death Differ. 2014 Feb;21(2):234-46. doi: 10.1038/cdd.2013.116.

PMID: 24037089

 

BMS-927711 for the acute treatment of migraine: a double-blind, randomized, placebo controlled, dose-ranging trial.

Marcus R, Goadsby PJ, Dodick D, Stock D, Manos G, Fischer TZ.

Cephalalgia. 2014 Feb;34(2):114-25. doi: 10.1177/0333102413500727.

PMID: 23965396

 

Pharmacokinetics, pharmacodynamics, and immunogenicity of belatacept in adult kidney transplant recipients.

Shen J, Townsend R, You X, Shen Y, Zhan P, Zhou Z, Geng D, Wu D, McGirr N, Soucek K, Proszynski E, Pursley J, Masson E.

Clin Drug Investig. 2014 Feb;34(2):117-26. doi: 10.1007/s40261-013-0153-2.

PMID: 24217983

 

Evaluation of various static and dynamic modeling methods to predict clinical CYP3A induction using in vitro CYP3A4 mRNA induction data.

Einolf HJ, Chen L, Fahmi OA, Gibson CR, Obach RS, Shebley M, Silva J, Sinz MW, Unadkat JD, Zhang L, Zhao P.

Clin Pharmacol Ther. 2014 Feb;95(2):179-88. doi: 10.1038/clpt.2013.170.

PMID: 23995268

 

Cost-effectiveness of apixaban versus other new oral anticoagulants for stroke prevention in atrial fibrillation.

Lip GY, Kongnakorn T, Phatak H, Kuznik A, Lanitis T, Liu LZ, Iloeje U, Hernandez L, Dorian P.

Clin Ther. 2014 Feb 1;36(2):192-210.e20. doi: 10.1016/j.clinthera.2013.12.011.

PMID: 24508420

 

Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation.

Zhu Y, Wang F, Li Q, Zhu M, Du A, Tang W, Chen W.

Drug Metab Dispos. 2014 Feb;42(2):245-9. doi: 10.1124/dmd.113.055400.

PMID: 24301608

 

Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection.

Everson GT, Sims KD, Rodriguez-Torres M, Hézode C, Lawitz E, Bourlière M, Loustaud-Ratti V, Rustgi V, Schwartz H, Tatum H, Marcellin P, Pol S, Thuluvath PJ, Eley T, Wang X, Huang SP, McPhee F, Wind-Rotolo M, Chung E, Pasquinelli C, Grasela DM, Gardiner DF.

Gastroenterology. 2014 Feb;146(2):420-9. doi: 10.1053/j.gastro.2013.10.057.

PMID: 24184132

 

A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.

Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M.

J Allergy Clin Immunol. 2014 Feb;133(2):448-60. doi: 10.1016/j.jaci.2013.10.048.

PMID: 24373353

 

Screening and characterization of reactive compounds with in vitro peptide-trapping and liquid chromatography/high-resolution accurate mass spectrometry.

Wei C, Chupak LS, Philip T, Johnson BM, Gentles R, Drexler DM.

J Biomol Screen. 2014 Feb;19(2):297-307. doi: 10.1177/1087057113492852.

PMID: 23796688

 

Bioanalysis of propylparaben and p-hydroxybenzoic acid, and their sulfate conjugates in rat plasma by liquid chromatography-tandem mass spectrometry.

Zhao Y, Liu G, Shen H, Shen JX, Aubry AF, Sivaraman L, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 1;947-948:68-74. doi: 10.1016/j.jchromb.2013.12.012.

PMID: 24412689

 

MR characterization of hepatic storage iron in transfusional iron overload.

Tang H, Jensen JH, Sammet CL, Sheth S, Swaminathan SV, Hultman K, Kim D, Wu EX, Brown TR, Brittenham GM.

J Magn Reson Imaging. 2014 Feb;39(2):307-16. doi: 10.1002/jmri.24171.

PMID: 23720394

 

Low level drug product API form analysis - Avalide tablet NIR quantitative method development and robustness challenges.

Pan D, Crull G, Yin S, Grosso J.

J Pharm Biomed Anal. 2014 Feb;89:268-75. doi: 10.1016/j.jpba.2013.11.011.

PMID: 24316453

 

Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS.

Zheng N, Zeng J, Ji QC, Angeles A, Buzescu A, Basdeo S, Aubry AF, Trouba K, Patrone LM, Peng Q, Arnold ME.

J Pharm Biomed Anal. 2014 Feb;89:240-50. doi: 10.1016/j.jpba.2013.11.017.

PMID: 24316424

 

Incidence and cost of stroke and hemorrhage in patients diagnosed with atrial fibrillation in France.

Cotté FE, Chaize G, Kachaner I, Gaudin AF, Vainchtock A, Durand-Zaleski I.

J Stroke Cerebrovasc Dis. 2014 Feb;23(2):e73-83. doi: 10.1016/j.jstrokecerebrovasdis.2013.08.022.

PMID: 24119623

 

The risk of long-term morbidity and mortality in patients with chronic hepatitis C: results from an analysis of data from a Department of Veterans Affairs Clinical Registry.

McCombs J, Matsuda T, Tonnu-Mihara I, Saab S, Hines P, L'italien G, Juday T, Yuan Y.

JAMA Intern Med. 2014 Feb 1;174(2):204-12. doi: 10.1001/jamainternmed.2013.12505.

PMID: 24193887

 

Outcome of pediatric acute myeloid leukemia patients receiving intensive care in the United States.

Maude SL, Fitzgerald JC, Fisher BT, Li Y, Huang YS, Torp K, Seif AE, Kavcic M, Walker DM, Leckerman KH, Kilbaugh TJ, Rheingold SR, Sung L, Zaoutis TE, Berg RA, Nadkarni VM, Thomas NJ, Aplenc R.

Pediatr Crit Care Med. 2014 Feb;15(2):112-20. doi: 10.1097/PCC.0000000000000042.

PMID: 24366507

 

Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats.

Jones KM, McDonald IM, Bourin C, Olson RE, Bristow LJ, Easton A.

Psychopharmacology (Berl). 2014 Feb;231(4):673-83. doi: 10.1007/s00213-013-3275-6.

PMID: 24057763

 

Accurate prediction of drug-induced liver injury using stem cell-derived populations.

Szkolnicka D, Farnworth SL, Lucendo-Villarin B, Storck C, Zhou W, Iredale JP, Flint O, Hay DC.

Stem Cells Transl Med. 2014 Feb;3(2):141-8. doi: 10.5966/sctm.2013-0146.

PMID: 24375539

 

Review of bilayer tablet technology.

Abebe A, Akseli I, Sprockel O, Kottala N, Cuitiño AM.

Int J Pharm. 2014 Jan 30;461(1-2):549-58. doi: 10.1016/j.ijpharm.2013.12.028. Review.

PMID: 24370841

 

Effects of reusing baseline volumes of interest by applying (non-)rigid image registration on positron emission tomography response assessments.

van Velden FH, Nissen IA, Hayes W, Velasquez LM, Hoekstra OS, Boellaard R.

PLoS One. 2014 Jan 28;9(1):e87167. doi: 10.1371/journal.pone.0087167.

PMID: 24489860

 

Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study.

Bhatia S, Curti B, Ernstoff MS, Gordon M, Heath EI, Miller WH Jr, Puzanov I, Quinn DI, Flaig TW, VanVeldhuizen P, Byrnes-Blake K, Freeman JA, Bittner R, Hunder N, Souza S, Thompson JA.

J Immunother Cancer. 2014 Jan 27;2:2. doi: 10.1186/2051-1426-2-2.

PMID: 24829759

 

The Economic Burden of Posttransplant Events in Renal Transplant Recipients in Europe.

Chamberlain G, Baboolal K, Bennett H, Pockett RD, McEwan P, Sabater J, Sennfält K.

Transplantation. 2014 Jan 22. [Epub ahead of print]

PMID: 24458103

 

Multicountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.

Dibonaventura MD, Yuan Y, Lescrauwaet B, L'italien G, Liu GG, Kamae I, Mauskopf JA.

PLoS One. 2014 Jan 21;9(1):e86070. doi: 10.1371/journal.pone.0086070.

PMID: 24465875

 

Mice lacking natural killer T cells are more susceptible to metabolic alterations following high fat diet feeding.

Martin-Murphy BV, You Q, Wang H, De La Houssaye BA, Reilly TP, Friedman JE, Ju C.

PLoS One. 2014 Jan 20;9(1):e80949. doi: 10.1371/journal.pone.0080949.

PMID: 24465369

 

Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection.

Sulkowski MS, Gardiner DF, Rodriguez-Torres M, Reddy KR, Hassanein T, Jacobson I, Lawitz E, Lok AS, Hinestrosa F, Thuluvath PJ, Schwartz H, Nelson DR, Everson GT, Eley T, Wind-Rotolo M, Huang SP, Gao M, Hernandez D, McPhee F, Sherman D, Hindes R, Symonds W, Pasquinelli C, Grasela DM; AI444040 Study Group..

N Engl J Med. 2014 Jan 16;370(3):211-21. doi: 10.1056/NEJMoa1306218. Erratum in: N Engl J Med. 2014 Apr 10;370(15):1469.

PMID:24428467

 

Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).

Ye XY, Yoon D, Chen SY, Nayeem A, Golla R, Seethala R, Wang M, Harper T, Sleczka BG, Apedo A, Li YX, He B, Kirby M, Gordon DA, Robl JA.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):654-60. doi: 10.1016/j.bmcl.2013.11.066.

PMID: 24360604

 

High-sensitivity troponin T and risk stratification in patients with atrial fibrillation during treatment with apixaban or warfarin.

Hijazi Z, Wallentin L, Siegbahn A, Andersson U, Alexander JH, Atar D, Gersh BJ, Hanna M, Harjola VP, Horowitz JD, Husted S, Hylek EM, Lopes RD, McMurray JJ, Granger CB; ARISTOTLE Investigators..

J Am Coll Cardiol. 2014 Jan 7-14;63(1):52-61. doi: 10.1016/j.jacc.2013.07.093.

PMID: 24055845

 

Ligand placement based on prior structures: the guided ligand-replacement method.

Klei HE, Moriarty NW, Echols N, Terwilliger TC, Baldwin ET, Pokross M, Posy S, Adams PD.

Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):134-43. doi: 10.1107/S1399004713030071.

PMID: 24419386

 

Cell culture process operations for recombinant protein production.

Abu-Absi S, Xu S, Graham H, Dalal N, Boyer M, Dave K.

Adv Biochem Eng Biotechnol. 2014;139:35-68. doi: 10.1007/10_2013_252.

PMID: 24153406

 

Developing novel blood-based biomarkers for Alzheimer's disease.

Snyder HM, Carrillo MC, Grodstein F, Henriksen K, Jeromin A, Lovestone S, Mielke MM, O'Bryant S, Sarasa M, Sjøgren M, Soares H, Teeling J, Trushina E, Ward M, West T, Bain LJ, Shineman DW, Weiner M, Fillit HM.

Alzheimers Dement. 2014 Jan;10(1):109-14. doi: 10.1016/j.jalz.2013.10.007. Review.

PMID: 24365657

 

The future of blood-based biomarkers for Alzheimer's disease.

Henriksen K, O'Bryant SE, Hampel H, Trojanowski JQ, Montine TJ, Jeromin A, Blennow K, Lönneborg A, Wyss-Coray T, Soares H, Bazenet C, Sjögren M, Hu W, Lovestone S, Karsdal MA, Weiner MW; Blood-Based Biomarker Interest Group..

Alzheimers Dement. 2014 Jan;10(1):115-31. doi: 10.1016/j.jalz.2013.01.013. Review.

PMID: 23850333

 

Association of plasma and cortical amyloid beta is modulated by APOE ε4 status.

Swaminathan S, Risacher SL, Yoder KK, West JD, Shen L, Kim S, Inlow M, Foroud T, Jagust WJ, Koeppe RA, Mathis CA, Shaw LM, Trojanowski JQ, Soares H, Aisen PS, Petersen RC, Weiner MW, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative..

Alzheimers Dement. 2014 Jan;10(1):e9-e18. doi: 10.1016/j.jalz.2013.01.007.

PMID: 23541187

 

Virological escape in HCV genotype-1-infected patients receiving daclatasvir plus ribavirin and peginterferon alfa-2a or alfa-2b.

McPhee F, Hernandez D, Zhou N, Yu F, Ueland J, Monikowski A, Chayama K, Toyota J, Izumi N, Yokosuka O, Kawada N, Osaki Y, Hughes EA, Watanabe H, Ishikawa H, Kumada H.

Antivir Ther. 2014;19(5):479-90. doi: 10.3851/IMP2729.

PMID: 24448487

 

Effect of the coadministration of daclatasvir on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and norgestimate.

Bifano M, Sevinsky H, Hwang C, Kandoussi H, Jiang H, Grasela D, Bertz R.

Antivir Ther. 2014;19(5):511-9. doi: 10.3851/IMP2718.

PMID: 24343001

 

Polymorph characterization of active pharmaceutical ingredients (APIs) using low-frequency Raman spectroscopy.

Larkin PJ, Dabros M, Sarsfield B, Chan E, Carriere JT, Smith BC.

Appl Spectrosc. 2014;68(7):758-76. doi: 10.1366/13-07329.

PMID: 25014842

 

Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation.

Münzer P, Borst O, Walker B, Schmid E, Feijge MA, Cosemans JM, Chatterjee M, Schmidt EM, Schmidt S, Towhid ST, Leibrock C, Elvers M, Schaller M, Seizer P, Ferlinz K, May AE, Gulbins E, Heemskerk JW, Gawaz M, Lang F.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):61-71. doi: 10.1161/ATVBAHA.112.300210.

PMID: 24233488

 

 High-throughput high-content imaging assays for identification and characterization of selective AXL pathway inhibitors.

Tang H, Yang J, Shen DR, Calambur D, Witmer M, Wu S, Carpenter B, Zhang Y, Gao M, Constantine K, Zhang L, Cvijic ME.

Assay Drug Dev Technol. 2014 Jan-Feb;12(1):80-6. doi: 10.1089/adt.2013.540.

PMID: 24547742

 

Quantitative determination of free/bound atazanavir via high-throughput equilibrium dialysis and LC-MS/MS, and the application in ex vivo samples.

Xu XS, Rose A, Demers R, Eley T, Ryan J, Stouffer B, Cojocaru L, Arnold M.

Bioanalysis. 2014;6(23):3169-82. doi: 10.4155/bio.14.251.

PMID: 25529885

 

Targeting an acid labile aspartyl-prolyl amide bond as a viable alternative to trypsin digestion to generate a surrogate peptide for LC-MS/MS analysis.

Fung EN, Zambito F, Haulenbeek J, Piccoli SP, Zhang Y, DeSilva B, Arnold M, Kozhich A.

Bioanalysis. 2014;6(22):2985-98. doi: 10.4155/bio.14.182.

PMID: 25496253

 

Bioanalysis of (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) in rat plasma using derivatization liquid chromatography/mass spectrometry.

Benitex Y, Luan FN, Shields E, McNaney CA, Morgan DG, Olah TV, Drexler DM.

Bioanalysis. 2014;6(14):1901-5. doi: 10.4155/bio.14.103.

PMID: 25158962

 

Applied Pharmaceutical Analysis India 2014 conference report.

Kole P, Barot D, Kotecha J, Raina V, Rao M, Yadav M.

Bioanalysis. 2014;6(14):1891-6. doi: 10.4155/bio.14.124.

PMID: 25158960

 

The integration of ligand binding and LC-MS-based assays into bioanalytical strategies for protein analysis.

Zhang YJ, Olah TV, Zeng J.

Bioanalysis. 2014;6(13):1827-41. doi: 10.4155/bio.14.128. Review.

PMID: 25157488

 

Quantification of human mAbs in mouse tissues using generic affinity enrichment procedures and LC-MS detection.

Sleczka BG, Mehl JT, Shuster DJ, Lewis KE, Moore R, Vuppugalla R, Rajendran S, D'Arienzo CJ, Olah TV.

Bioanalysis. 2014;6(13):1795-811. doi: 10.4155/bio.14.143.

PMID: 25157486

 

An exploratory universal LC-MS/MS assay for bioanalysis of hinge region-stabilized human IgG4 mAbs in clinical studies.

Furlong MT, Titsch C, Xu W, Jiang H, Jemal M, Zeng J.

Bioanalysis. 2014;6(13):1747-58. doi: 10.4155/bio.14.64.

PMID: 24661028

 

Risks of decreased renal function and increased albuminuria for glycemic status and metabolic syndrome components: Taichung Community Health study.

Lin CC, Li CI, Liu CS, Lin WY, Lin CH, Lai MM, Lee YD, Chen CC, Yang CW, Li TC.

Biomed Res Int. 2014;2014:841497. doi: 10.1155/2014/841497.

PMID: 24900991

 

Clarification and capture of high-concentration refold pools for E. coli-based therapeutics using expanded bed adsorption chromatography.

Xu X, Hirpara J, Epting K, Jin M, Ghose S, Rieble S, Li ZJ.

Biotechnol Prog. 2014 Jan-Feb;30(1):113-23. doi: 10.1002/btpr.1833.

PMID: 24167114

 

Molecular detection and prognostic value of epithelial markers mRNA expression in peripheral blood of advanced non-small cell lung cancer patients.

Arrieta O, Pineda B, Muñiz-Hernández S, Flores D, Ordóñez G, Borbolla-Escoboza JR, Orta D.

Cancer Biomark. 2014;14(4):215-23. doi: 10.3233/CBM-140394.

PMID: 24934364

 

Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor.

Callahan MK, Masters G, Pratilas CA, Ariyan C, Katz J, Kitano S, Russell V, Gordon RA, Vyas S, Yuan J, Gupta A, Wigginton JM, Rosen N, Merghoub T, Jure-Kunkel M, Wolchok JD.

Cancer Immunol Res. 2014 Jan;2(1):70-9. doi: 10.1158/2326-6066.CIR-13-0160.

PMID: 24416731

 

Understanding the standard of care in the treatment of type 2 diabetes in China: results from a national survey.

Ji L, Newman J, Lu J, Cai X.

Chin Med J (Engl). 2014;127(20):3524-9.

PMID: 25316223

 

Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2.

Kasichayanula S, Liu X, Lacreta F, Griffen SC, Boulton DW.

Clin Pharmacokinet. 2014 Jan;53(1):17-27. doi: 10.1007/s40262-013-0104-3. Review.

PMID: 24105299

 

Dapagliflozin as monotherapy in drug-naive Asian patients with type 2 diabetes mellitus: a randomized, blinded, prospective phase III study.

Ji L, Ma J, Li H, Mansfield TA, T'joen CL, Iqbal N, Ptaszynska A, List JF.

Clin Ther. 2014 Jan 1;36(1):84-100.e9. doi: 10.1016/j.clinthera.2013.11.002.

PMID: 24378206

 

Beyond the ITC White Paper: emerging sciences in drug transporters and opportunities for drug development.

Lai Y, Hsiao P.

Curr Pharm Des. 2014;20(10):1577-94. Review.

PMID: 23789952

 

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications.

Wei H, Mo J, Tao L, Russell RJ, Tymiak AA, Chen G, Iacob RE, Engen JR.

Drug Discov Today. 2014 Jan;19(1):95-102. doi: 10.1016/j.drudis.2013.07.019. Review.

PMID: 23928097

 

A systematic evaluation of solubility enhancing excipients to enable the generation of permeability data for poorly soluble compounds in Caco-2 model.

Shah D, Paruchury S, Matta M, Chowan G, Subramanian M, Saxena A, Soars MG, Herbst J, Haskell R, Marathe P, Mandlekar S.

Drug Metab Lett. 2014;8(2):109-18.

PMID: 25429513

 

Quality of life and satisfaction with treatment in subjects with type 2 diabetes: results in Spain of the PANORAMA study.

Depablos-Velasco P, Salguero-Chaves E, Mata-Poyo J, Derivas-Otero B, García-Sánchez R, Viguera-Ester P.

Endocrinol Nutr. 2014 Jan;61(1):18-26. doi: 10.1016/j.endonu.2013.05.005. English, Spanish.

PMID: 24055176

 

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.

Toyn JH, Thompson LA, Lentz KA, Meredith JE Jr, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, Denton RR, Grace JE, Morrison J, Raybon J, Zhuo X, Snow K, Padmanabha R, Agler M, Esposito K, Harden D, Prack M, Varma S, Wong V, Zhu Y, Zvyaga T, Gerritz S, Marcin LR, Higgins MA, Shi J, Wei C, Cantone JL, Drexler DM, Macor JE, Olson RE, Ahlijanian MK, Albright CF.

Int J Alzheimers Dis. 2014;2014:431858. doi: 10.1155/2014/431858.

PMID: 25097793

 

Five-year safety evaluation of maraviroc in HIV-1-infected treatment-experienced patients.

Gulick RM, Fatkenheuer G, Burnside R, Hardy WD, Nelson MR, Goodrich J, Mukwaya G, Portsmouth S, Heera JR.

J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):78-81. doi: 10.1097/QAI.0b013e3182a7a97a.

PMID: 24419064

 

Synthesis of [3α-(3) H] 17α-hydroxy pregnenolone and [3α-(3) H] pregnenolone.

Tian Y, Hong Y, Bonacorsi SJ, Balog A, Gong S.

J Labelled Comp Radiopharm. 2014 Jan;57(1):1-11. doi: 10.1002/jlcr.3114.

PMID: 24448740

 

Application of a stabilizer cocktail of N-ethylmaleimide and phenylmethanesulfonyl fluoride to concurrently stabilize the disulfide and ester containing compounds in a plasma LC-MS/MS assay.

Yuan L, Jian W, Zhang D, Aubry AF, Arnold ME.

J Pharm Biomed Anal. 2014 Jan;88:552-61. doi: 10.1016/j.jpba.2013.10.014.

PMID: 24211707

 

Improving the efficiency of quantitative (1)H NMR: an innovative external standard-internal reference approach.

Huang Y, Su BN, Ye Q, Palaniswamy VA, Bolgar MS, Raglione TV.

J Pharm Biomed Anal. 2014 Jan;88:1-6. doi: 10.1016/j.jpba.2013.07.043.

PMID: 24013124

 

Preclinical QT safety assessment: cross-species comparisons and human translation from an industry consortium.

Holzgrefe H, Ferber G, Champeroux P, Gill M, Honda M, Greiter-Wilke A, Baird T, Meyer O, Saulnier M.

J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):61-101. doi: 10.1016/j.vascn.2013.05.004.

PMID: 23689033

 

 Sleep problems in patients with rheumatoid arthritis.

Westhovens R, Van der Elst K, Matthys A, Tran M, Gilloteau I.

J Rheumatol. 2014 Jan;41(1):31-40. doi: 10.3899/jrheum.130430.

PMID: 24293569

 

NMR methods for metabolomics of mammalian cell culture bioreactors.

Aranibar N, Reily MD.

Methods Mol Biol. 2014;1104:223-36. doi: 10.1007/978-1-62703-733-4_15.

PMID: 24297419

 

Functional annotation of differentially regulated gene set using WebGestalt: a gene set predictive of response to ipilimumab in tumor biopsies.

Kirov S, Ji R, Wang J, Zhang B.

Methods Mol Biol. 2014;1101:31-42. doi: 10.1007/978-1-62703-721-1_3.

PMID: 24233776

 

Molecular basis of crystal morphology-dependent adhesion behavior of mefenamic acid during tableting.

Waknis V, Chu E, Schlam R, Sidorenko A, Badawy S, Yin S, Narang AS.

Pharm Res. 2014 Jan;31(1):160-72. doi: 10.1007/s11095-013-1149-6.

PMID: 23943544

 

Regulatory forum opinion piece: Peer review documentation and pathology data locking.

Neef N.

Toxicol Pathol. 2014;42(2):311-3. doi: 10.1177/0192623313517060. No abstract available.

PMID: 24357644

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2013 Publications

Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors.

Zhang X, Jiang W, Jacutin-Porte S, Glunz PW, Zou Y, Cheng X, Nirschl AH, Wurtz NR, Luettgen JM, Rendina AR, Luo G, Harper TM, Wei A, Anumula R, Cheney DL, Knabb RM, Wong PC, Wexler RR, Priestley ES.

ACS Med Chem Lett. 2013 Dec 26;5(2):188-92. doi: 10.1021/ml400453z.

PMID: 24900796

 

Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds.

Ruel R, L'Heureux A, Thibeault C, Lapointe P, Martel A, Qiao JX, Hua J, Price LA, Wu Q, Chang M, Zheng J, Huang CS, Wexler RR, Rehfuss R, Lam PY.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6825-8. doi: 10.1016/j.bmcl.2013.10.009.

PMID: 24269480

 

Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.

Ellsworth BA, Sher PM, Wu X, Wu G, Sulsky RB, Gu Z, Murugesan N, Zhu Y, Yu G, Sitkoff DF, Carlson KE, Kang L, Yang Y, Lee N, Baska RA, Keim WJ, Cullen MJ, Azzara AV, Zuvich E, Thomas MA, Rohrbach KW, Devenny JJ, Godonis HE, Harvey SJ, Murphy BJ, Everlof GG, Stetsko PI, Gudmundsson O, Johnghar S, Ranasinghe A, Behnia K, Pelleymounter MA, Ewing WR.

J Med Chem. 2013 Dec 12;56(23):9586-600. doi: 10.1021/jm4010835.

PMID: 24182233

 

Single- and multiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban in healthy Chinese subjects.

Cui Y, Song Y, Wang J, Yu Z, Schuster A, Barrett YC, Frost C.

Clin Pharmacol. 2013 Dec 6;5:177-84. doi: 10.2147/CPAA.S51981. Erratum in: Clin Pharmacol. 2014;6:61.

PMID: 24353445

 

Orthogonal high-throughput thermal scanning method for rank ordering protein formulations.

Nashine VC, Kroetsch AM, Sahin E, Zhou R, Adams ML.

AAPS PharmSciTech. 2013 Dec;14(4):1360-6. doi: 10.1208/s12249-013-0026-2.

PMID: 24002823

 

BMS-986001, an HIV nucleoside reverse transcriptase inhibitor, does not degrade mitochondrial DNA in long-term primary cultures of cells isolated from human kidney, muscle, and adipose tissue.

Wang F, Flint OP.

Antimicrob Agents Chemother. 2013 Dec;57(12):6205-12. doi: 10.1128/AAC.01206-13.

PMID: 24080659

 

Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects.

Upreti VV, Wang J, Barrett YC, Byon W, Boyd RA, Pursley J, LaCreta FP, Frost CE.

Br J Clin Pharmacol. 2013 Dec;76(6):908-16. doi: 10.1111/bcp.12114.

PMID: 23488672

 

Diagnoses associated with use of atypical antipsychotics in a commercial health plan: a claims database analysis.

Citrome L, Kalsekar I, Guo Z, Laubmeier K, Hebden T.

Clin Ther. 2013 Dec;35(12):1867-75. doi: 10.1016/j.clinthera.2013.09.006.

PMID: 24119767

 

Assessment of vandetanib as an inhibitor of various human renal transporters: inhibition of multidrug and toxin extrusion as a possible mechanism leading to decreased cisplatin and creatinine clearance.

Shen H, Yang Z, Zhao W, Zhang Y, Rodrigues AD.

Drug Metab Dispos. 2013 Dec;41(12):2095-103. doi: 10.1124/dmd.113.053215.

PMID: 24026623

 

Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma.

Weber JS, Kudchadkar RR, Yu B, Gallenstein D, Horak CE, Inzunza HD, Zhao X, Martinez AJ, Wang W, Gibney G, Kroeger J, Eysmans C, Sarnaik AA, Chen YA.

J Clin Oncol. 2013 Dec 1;31(34):4311-8. doi: 10.1200/JCO.2013.51.4802.

PMID: 24145345

 

Peginterferon Lambda-1a, a New Therapeutic for Hepatitis C Infection, from Bench to Clinic.

Andersen H, Meyer J, Freeman J, Doyle SE, Klucher K, Miller DM, Hausman D, Hillson JL.

J Clin Transl Hepatol. 2013 Dec;1(2):116-24. doi: 10.14218/JCTH.2013.00014. Review.

PMID: 26357610

 

Evaluation of integrated Raman-DSC technology in early pharmaceutical development: characterization of polymorphic systems.

Huang J, Dali M.

J Pharm Biomed Anal. 2013 Dec;86:92-9. doi: 10.1016/j.jpba.2013.08.004.

PMID: 23995752

 

The effect of the physical state of binders on high-shear wet granulation and granule properties: a mechanistic approach to understand the high-shear wet granulation process. part IV. the impact of rheological state and tip-speeds.

Li J, Tao L, Buckley D, Tao J, Gao J, Hubert M.

J Pharm Sci. 2013 Dec;102(12):4384-94. doi: 10.1002/jps.23750.

PMID: 24135976

 

Imaging dehydration kinetics of a channel hydrate form of the HIV-1 attachment inhibitor prodrug BMS-663068.

Leane MM, Gamble JF, Brown J, Hughes H, Crull G, Engstrom J, Gao Q, Bunker M, Rutherford S, Parker A, Roberts CJ, Tobyn M.

J Pharm Sci. 2013 Dec;102(12):4375-83. doi: 10.1002/jps.23747.

PMID: 24129913

 

Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.

Qiao JX, Wang TC, Ruel R, Thibeault C, L'Heureux A, Schumacher WA, Spronk SA, Hiebert S, Bouthillier G, Lloyd J, Pi Z, Schnur DM, Abell LM, Hua J, Price LA, Liu E, Wu Q, Steinbacher TE, Bostwick JS, Chang M, Zheng J, Gao Q, Ma B, McDonnell PA, Huang CS, Rehfuss R, Wexler RR, Lam PY.

J Med Chem. 2013 Nov 27;56(22):9275-95. doi: 10.1021/jm4013906.

PMID: 24164581

 

Practical and economical implementation of online H/D exchange in LC-MS.

Shah RP, Garg A, Putlur SP, Wagh S, Kumar V, Rao V, Singh S, Mandlekar S, Desikan S.

Anal Chem. 2013 Nov 19;85(22):10904-12. doi: 10.1021/ac402339s.

PMID: 24117319

 

Introduction of a new scaling approach for particle size reduction in toothed rotor-stator wet mills.

Engstrom J, Wang C, Lai C, Sweeney J.

Int J Pharm. 2013 Nov 18;456(2):261-8. doi: 10.1016/j.ijpharm.2013.08.084.

PMID: 24012859

 

Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.

Wu YJ, Conway CM, Sun LQ, Machet F, Chen J, Chen P, He H, Bourin C, Calandra V, Polino JL, Davis CD, Heman K, Gribkoff VK, Boissard CG, Knox RJ, Thompson MW, Fitzpatrick W, Weaver D, Harden DG, Natale J, Dworetzky SI, Starrett JE Jr.

Bioorg Med Chem Lett. 2013 Nov 15;23(22):6188-91. doi: 10.1016/j.bmcl.2013.08.092.

PMID: 24070783

 

Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model.

Morales-Kastresana A, Sanmamed MF, Rodriguez I, Palazon A, Martinez-Forero I, Labiano S, Hervas-Stubbs S, Sangro B, Ochoa C, Rouzaut A, Azpilikueta A, Bolaños E, Jure-Kunkel M, Gütgemann I, Melero I.

Clin Cancer Res. 2013 Nov 15;19(22):6151-62. doi: 10.1158/1078-0432.CCR-13-1189.

PMID: 24030703

 

 

Assessing the risk of pH-dependent absorption for new molecular entities: a novel in vitro dissolution test, physicochemical analysis, and risk assessment strategy.

Mathias NR, Xu Y, Patel D, Grass M, Caldwell B, Jager C, Mullin J, Hansen L, Crison J, Saari A, Gesenberg C, Morrison J, Vig B, Raghavan K.

Mol Pharm. 2013 Nov 4;10(11):4063-73. doi: 10.1021/mp400426f.

PMID: 24032349

 

In vitro cross-resistance profile of nucleoside reverse transcriptase inhibitor (NRTI) BMS-986001 against known NRTI resistance mutations.

Li Z, Terry B, Olds W, Protack T, Deminie C, Minassian B, Nowicka-Sans B, Sun Y, Dicker I, Hwang C, Lataillade M, Hanna GJ, Krystal M.

Antimicrob Agents Chemother. 2013 Nov;57(11):5500-8. doi: 10.1128/AAC.01195-13.

PMID: 23979732

 

Gene expression analyses of mouse aortic endothelium in response to atherogenic stimuli.

Erbilgin A, Siemers N, Kayne P, Yang WP, Berliner J, Lusis AJ.

Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2509-17. doi: 10.1161/ATVBAHA.113.301989.

PMID: 23990205

 

 Safety, pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban, a factor Xa inhibitor, in healthy subjects.

Frost C, Nepal S, Wang J, Schuster A, Byon W, Boyd RA, Yu Z, Shenker A, Barrett YC, Mosqueda-Garcia R, Lacreta F.

Br J Clin Pharmacol. 2013 Nov;76(5):776-86. doi: 10.1111/bcp.12106.

PMID: 23451769

 

Metabolomics in drug discovery and development.

Robertson DG, Frevert U.

Clin Pharmacol Ther. 2013 Nov;94(5):559-61. doi: 10.1038/clpt.2013.120.

PMID: 24145714

 

A monovalent anti-human CD28 domain antibody antagonist: preclinical efficacy and safety.

Suchard SJ, Davis PM, Kansal S, Stetsko DK, Brosius R, Tamura J, Schneeweis L, Bryson J, Salcedo T, Wang H, Yang Z, Fleener CA, Ignatovich O, Plummer C, Grant S, Nadler SG.

J Immunol. 2013 Nov 1;191(9):4599-610. doi: 10.4049/jimmunol.1300470.

PMID: 24081989

 

Pharmaceutical development and regulatory considerations for nanoparticles and nanoparticulate drug delivery systems.

Narang AS, Chang RK, Hussain MA.

J Pharm Sci. 2013 Nov;102(11):3867-82. doi: 10.1002/jps.23691.

PMID: 24037829

 

Crystal structure of rat intestinal alkaline phosphatase--role of crown domain in mammalian alkaline phosphatases.

Ghosh K, Mazumder Tagore D, Anumula R, Lakshmaiah B, Kumar PP, Singaram S, Matan T, Kallipatti S, Selvam S, Krishnamurthy P, Ramarao M.

J Struct Biol. 2013 Nov;184(2):182-92. doi: 10.1016/j.jsb.2013.09.017.

PMID: 24076154

 

Formulation design, challenges, and development considerations for fixed dose combination (FDC) of oral solid dosage forms.

Desai D, Wang J, Wen H, Li X, Timmins P.

Pharm Dev Technol. 2013 Nov-Dec;18(6):1265-76. doi: 10.3109/10837450.2012.660699. Review.

PMID: 22339230

 

Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease.

Easton A, Sankaranarayanan S, Tanghe A, Terwel D, Lin AX, Hoque N, Bourin C, Gu H, Ahlijanian M, Bristow L.

Psychopharmacology (Berl). 2013 Nov;230(2):279-89. doi: 10.1007/s00213-013-3152-3.

PMID: 23783773

 

Statistical issues and challenges in immuno-oncology.

Chen TT.

J Immunother Cancer. 2013 Oct 21;1:18. doi: 10.1186/2051-1426-1-18.

PMID: 24829754

 

Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population.

Colilla S, Crow A, Petkun W, Singer DE, Simon T, Liu X.

Am J Cardiol. 2013 Oct 15;112(8):1142-7. doi: 10.1016/j.amjcard.2013.05.063.

PMID: 23831166

 

Altering drug tolerance of surface plasmon resonance assays for the detection of anti-drug antibodies.

Barbosa MD, Gokemeijer J, Martin AD, Bush A.

Anal Biochem. 2013 Oct 15;441(2):174-9. doi: 10.1016/j.ab.2013.07.019.

PMID: 23886888

 

Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.

Jiang H, Zeng J, Titsch C, Voronin K, Akinsanya B, Luo L, Shen H, Desai DD, Allentoff A, Aubry AF, Desilva BS, Arnold ME.

Anal Chem. 2013 Oct 15;85(20):9859-67. doi: 10.1021/ac402420v.

PMID: 24024648

 

Heterocyclic glucocorticoid receptor modulators with a 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core.

Xiao HY, Wu DR, Sheppeck JE 2nd, Habte SF, Cunningham MD, Somerville JE, Barrish JC, Nadler SG, Dhar TG.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5571-4. doi: 10.1016/j.bmcl.2013.08.049.

PMID: 24011644

 

Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists.

Tora G, Degnan AP, Conway CM, Kostich WA, Davis CD, Pin SS, Schartman R, Xu C, Widmann KA, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5684-8. doi: 10.1016/j.bmcl.2013.08.031.

PMID: 23993336

 

Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease.

Meredith JE Jr, Sankaranarayanan S, Guss V, Lanzetti AJ, Berisha F, Neely RJ, Slemmon JR, Portelius E, Zetterberg H, Blennow K, Soares H, Ahlijanian M, Albright CF.

PLoS One. 2013 Oct 7;8(10):e76523. doi: 10.1371/journal.pone.0076523.

PMID: 24116116

 

Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.

Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I; SAVOR-TIMI 53 Steering Committee and Investigators..

N Engl J Med. 2013 Oct 3;369(14):1317-26. doi: 10.1056/NEJMoa1307684.

PMID: 23992601

 

Amino acids as promoieties in prodrug design and development.

Vig BS, Huttunen KM, Laine K, Rautio J.

Adv Drug Deliv Rev. 2013 Oct;65(10):1370-85. doi: 10.1016/j.addr.2012.10.001. Review.

PMID: 23099277

 

Clinical and pharmacogenetic factors affecting neonatal bilirubinemia following atazanavir treatment of mothers during pregnancy.

Eley T, Huang SP, Conradie F, Zorrilla CD, Josipovic D, Botes M, Osiyemi O, Hardy H, Bertz R, McGrath D.

AIDS Res Hum Retroviruses. 2013 Oct;29(10):1287-92. doi: 10.1089/AID.2013.0002.

PMID: 23782005

 

Cost of venous thromboembolism in hospitalized medically ill patients.

Pendergraft T, Atwood M, Liu X, Phatak H, Liu LZ, Oster G.

Am J Health Syst Pharm. 2013 Oct 1;70(19):1681-7. doi: 10.2146/ajhp130099.

PMID: 24048605

 

Systematic investigation of orthogonal SPE sample preparation for the LC-MS/MS bioanalysis of a monoclonal antibody after pellet digestion.

Yuan L, Aubry AF, Arnold ME, Ji QC.

Bioanalysis. 2013 Oct;5(19):2379-91. doi: 10.4155/bio.13.224.

PMID: 24066623

 

Conference report: energized bioanalytical solutions at the 2012 Eastern Analytical Symposium & Exposition.

Liu A, Aubry AF.

Bioanalysis. 2013 Oct;5(19):2341-4. doi: 10.4155/bio.13.228.

PMID: 24066619

 

Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.

Gilmore JL, Sheppeck JE 2nd, Wang J, Dhar TG, Cavallaro C, Doweyko AM, Mckay L, Cunningham MD, Habte SF, Nadler SG, Dodd JH, Somerville JE, Barrish JC.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5448-51. doi: 10.1016/j.bmcl.2013.06.085.

PMID: 23916594

 

Pharmacokinetics of the NS3 Protease Inhibitor, Asunaprevir (ASV, BMS-650032), in Phase I Studies in Subjects With or Without Chronic Hepatitis C.

Eley T, He B, Huang SP, Li W, Pasquinelli C, Rodrigues AD, Grasela DM, Bertz RJ.

Clin Pharmacol Drug Dev. 2013 Oct;2(4):316-27. doi: 10.1002/cpdd.52.

PMID: 27121936

 

Antiviral activity and resistance of HCV NS5A replication complex inhibitors.

Gao M.

Curr Opin Virol. 2013 Oct;3(5):514-20. doi: 10.1016/j.coviro.2013.06.014. Review.

PMID: 23896281

 

Development of novel, 384-well high-throughput assay panels for human drug transporters: drug interaction and safety assessment in support of discovery research.

Tang H, Shen DR, Han YH, Kong Y, Balimane P, Marino A, Gao M, Wu S, Xie D, Soars MG, O'Connell JC, Rodrigues AD, Zhang L, Cvijic ME.

J Biomol Screen. 2013 Oct;18(9):1072-83. doi: 10.1177/1087057113494807.

PMID: 24062352

 

Establishing a high-throughput and automated cancer cell proliferation panel for oncology lead optimization.

Lei M, Ribeiro H, Kolodin G, Gill J, Wang YS, Maloney D, Fan Y, Li S, Myer L, Beluch M, Zhang L, Schweizer L.

J Biomol Screen. 2013 Oct;18(9):1043-53. doi: 10.1177/1087057113491825.

PMID: 23733846

 

Aripiprazole treatment of irritability associated with autistic disorder and the relationship between prior antipsychotic exposure, adverse events, and weight change.

Mankoski R, Stockton G, Manos G, Marler S, McQuade R, Forbes RA, Marcus R.

J Child Adolesc Psychopharmacol. 2013 Oct;23(8):572-6. doi: 10.1089/cap.2012.0075.

PMID: 24138011

 

Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study.

Llovet JM, Decaens T, Raoul JL, Boucher E, Kudo M, Chang C, Kang YK, Assenat E, Lim HY, Boige V, Mathurin P, Fartoux L, Lin DY, Bruix J, Poon RT, Sherman M, Blanc JF, Finn RS, Tak WY, Chao Y, Ezzeddine R, Liu D, Walters I, Park JW.

J Clin Oncol. 2013 Oct 1;31(28):3509-16. doi: 10.1200/JCO.2012.47.3009.

PMID: 23980090

 

Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study.

Johnson PJ, Qin S, Park JW, Poon RT, Raoul JL, Philip PA, Hsu CH, Hu TH, Heo J, Xu J, Lu L, Chao Y, Boucher E, Han KH, Paik SW, Robles-Aviña J, Kudo M, Yan L, Sobhonslidsuk A, Komov D, Decaens T, Tak WY, Jeng LB, Liu D, Ezzeddine R, Walters I, Cheng AL.

J Clin Oncol. 2013 Oct 1;31(28):3517-24. doi: 10.1200/JCO.2012.48.4410.

PMID: 23980084

 

Efficacy and safety of ixabepilone plus capecitabine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer.

Vahdat LT, Vrdoljak E, Gómez H, Li RK, Bosserman L, Sparano JA, Baselga J, Mukhopadhyay P, Valero V.

J Geriatr Oncol. 2013 Oct;4(4):346-52. doi: 10.1016/j.jgo.2013.07.006.

PMID: 24472478

 

Neither direct nor developmental exposure to bisphenol A alters the severity of experimental inflammatory colitis in mice.

Roy A, Gaylo A, Cao W, Saubermann LJ, Lawrence BP.

J Immunotoxicol. 2013 Oct-Dec;10(4):334-40. doi: 10.3109/1547691X.2012.747231.

PMID: 23282445

 

A computational method for planning complex compound distributions under container, liquid handler, and assay constraints.

Russo MF, Wild D, Hoffman S, Paulson J, Neil W, Nirschl DS.

J Lab Autom. 2013 Oct;18(5):391-403. doi: 10.1177/2211068213486651.

PMID: 23603752

 

An alternative and robust synthesis of [(13) C4 ]Baraclude® (entecavir).

Easter JA, Burrell RC, Bonacorsi SJ Jr.

J Labelled Comp Radiopharm. 2013 Oct;56(12):632-6. doi: 10.1002/jlcr.3064.

PMID: 24285240

 

Mechanistic insights into the scale-up of the roller compaction process: a practical and dimensionless approach.

Rowe JM, Crison JR, Carragher TJ, Vatsaraj N, McCann RJ, Nikfar F.

J Pharm Sci. 2013 Oct;102(10):3586-95. doi: 10.1002/jps.23659.

PMID: 23934748

 

A 96-well based analysis of replicon elimination with the HCV NS5A replication complex inhibitor daclatasvir.

O'Boyle DR 2nd, Nower PT, Sun JH, Fridell R, Wang C, Valera L, Gao M.

J Virol Methods. 2013 Oct;193(1):68-76. doi: 10.1016/j.jviromet.2013.04.024.

PMID: 23684844

 

NK1 receptor antagonism lowers occupancy requirement for antidepressant-like effects of SSRIs in the gerbil forced swim test.

Lelas S, Li YW, Wallace-Boone TL, Taber MT, Newton AE, Pieschl RL, Davis CD, Molski TF, Newberry KS, Parker MF, Gillman KW, Bronson JJ, Macor JE, Lodge NJ.

Neuropharmacology. 2013 Oct;73:232-40. doi: 10.1016/j.neuropharm.2013.05.038.

PMID: 23770339

 

MK-801 disrupts and nicotine augments 40 Hz auditory steady state responses in the auditory cortex of the urethane-anesthetized rat.

Sivarao DV, Frenkel M, Chen P, Healy FL, Lodge NJ, Zaczek R.

Neuropharmacology. 2013 Oct;73:1-9. doi: 10.1016/j.neuropharm.2013.05.006.

PMID: 23688921

 

Use of low-dose clinical pharmacodynamic and pharmacokinetic data to establish an occupational exposure limit for dapagliflozin, a potent inhibitor of the renal sodium glucose co-transporter 2.

Gould JC, Kasichayanula S, Shepperly DC, Boulton DW.

Regul Toxicol Pharmacol. 2013 Oct;67(1):89-97. doi: 10.1016/j.yrtph.2013.07.002.

PMID: 23851069

 

Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778).

Devasthale P, Wang Y, Wang W, Fevig J, Feng J, Wang A, Harrity T, Egan D, Morgan N, Cap M, Fura A, Klei HE, Kish K, Weigelt C, Sun L, Levesque P, Moulin F, Li YX, Zahler R, Kirby MS, Hamann LG.

J Med Chem. 2013 Sep 26;56(18):7343-57. doi: 10.1021/jm4008906.

PMID: 23964740

 

A safe, effective, and facility compatible cleaning in place procedure for affinity resin in large-scale monoclonal antibody purification.

Wang L, Dembecki J, Jaffe NE, O'Mara BW, Cai H, Sparks CN, Zhang J, Laino SG, Russell RJ, Wang M.

J Chromatogr A. 2013 Sep 20;1308:86-95. doi: 10.1016/j.chroma.2013.07.096.

PMID: 23953712

 

Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.

Bolton SA, Sutton JC, Anumula R, Bisacchi GS, Jacobson B, Slusarchyk WA, Treuner UD, Wu SC, Zhao G, Pi Z, Sheriff S, Smirk RA, Bisaha S, Cheney DL, Wei A, Schumacher WA, Hartl KS, Liu E, Zahler R, Seiler SM.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5239-43. doi: 10.1016/j.bmcl.2013.06.028.

PMID: 23927973

 

Nonbenzamidine acylsulfonamide tissue factor-factor VIIa inhibitors.

Glunz PW, Zhang X, Zou Y, Delucca I, Nirschl AH, Cheng X, Weigelt CA, Cheney DL, Wei A, Anumula R, Luettgen JM, Rendina AR, Harpel M, Luo G, Knabb R, Wong PC, Wexler RR, Priestley ES.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5244-8. doi: 10.1016/j.bmcl.2013.06.027.

PMID: 23845220

 

MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459.

Simic D, Euler C, Haines E, He A, Peden WM, Bunch RT, Sanderson T, Van Vleet T.

Toxicology. 2013 Sep 15;311(3):169-77. doi: 10.1016/j.tox.2013.06.006.

PMID: 23831372

 

DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues.

Harstad EB, Rosenblum JS, Gorrell MD, Achanzar WE, Minimo L, Wu J, Rosini-Marthaler L, Gullo R, Ordway ND, Kirby MS, Chadwick KD, Cosma GN, Moyer CF.

Regul Pept. 2013 Sep 10;186:26-35. doi: 10.1016/j.regpep.2013.07.003.

PMID: 23850796

 

Cost-effectiveness of the once-daily efavirenz/emtricitabine/tenofovir tablet compared with the once-daily elvitegravir/cobicistat/emtricitabine/tenofovir tablet as first-line antiretroviral therapy in HIV-infected adults in the US.

Juday T, Correll T, Anene A, Broder MS, Ortendahl J, Bentley T.

Clinicoecon Outcomes Res. 2013 Sep 2;5:437-45. doi: 10.2147/CEOR.S47486.

PMID: 24039438

 

Activity of the HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068, against CD4-independent viruses and HIV-1 envelopes resistant to other entry inhibitors.

Li Z, Zhou N, Sun Y, Ray N, Lataillade M, Hanna GJ, Krystal M.

Antimicrob Agents Chemother. 2013 Sep;57(9):4172-80. doi: 10.1128/AAC.00513-13.

PMID: 23774428

 

 The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitus.

Kasichayanula S, Liu X, Pe Benito M, Yao M, Pfister M, LaCreta FP, Humphreys WG, Boulton DW.

Br J Clin Pharmacol. 2013 Sep;76(3):432-44. doi: 10.1111/bcp.12056.

PMID: 23210765

 

Association between insulin resistance and sustained virologic response in hepatitis C treatment, genotypes 1 versus 2 and 3: systematic literature review and meta-analysis.

Laurito MP, Parise ER.

Braz J Infect Dis. 2013 Sep-Oct;17(5):555-63. doi: 10.1016/j.bjid.2013.02.009. Review.

PMID: 24055394

 

 Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models.

Jure-Kunkel M, Masters G, Girit E, Dito G, Lee F, Hunt JT, Humphrey R.

Cancer Immunol Immunother. 2013 Sep;62(9):1533-45. doi: 10.1007/s00262-013-1451-5.

PMID: 23873089

 

 A novel prothrombin time assay for assessing the anticoagulant activity of oral factor Xa inhibitors.

Barrett YC, Wang Z, Knabb RM.

Clin Appl Thromb Hemost. 2013 Sep;19(5):522-8. doi: 10.1177/1076029612441859.

PMID: 22473028

 

Degradation of BMS-753493, a novel epothilone folate conjugate anticancer agent.

Gokhale M, Thakur A, Rinaldi F.

Drug Dev Ind Pharm. 2013 Sep;39(9):1315-27. doi: 10.3109/03639045.2012.728226.

PMID: 23039020

 

Novel drug discovery opportunities for colorectal cancer.

Curtin JC.

Expert Opin Drug Discov. 2013 Sep;8(9):1153-64. doi: 10.1517/17460441.2013.807249. Review.

PMID: 23768167

 

[Ipilimumab].

Tokudome T.

Gan To Kagaku Ryoho. 2013 Sep;40(9):1140-4. Japanese.

PMID: 24047771

 

Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir.

McPhee F, Hernandez D, Yu F, Ueland J, Monikowski A, Carifa A, Falk P, Wang C, Fridell R, Eley T, Zhou N, Gardiner D.

Hepatology. 2013 Sep;58(3):902-11. doi: 10.1002/hep.26388.

PMID: 23504694

 

Nonclinical toxicology assessments support the chronic safety of dapagliflozin, a first-in-class sodium-glucose cotransporter 2 inhibitor.

Tirmenstein M, Dorr TE, Janovitz EB, Hagan D, Abell LM, Onorato JM, Whaley JM, Graziano MJ, Reilly TP.

Int J Toxicol. 2013 Sep-Oct;32(5):336-50. doi: 10.1177/1091581813505331.

PMID: 24097127

 

Prediction of virological response and assessment of resistance emergence to the HIV-1 attachment inhibitor BMS-626529 during 8-day monotherapy with its prodrug BMS-663068.

Ray N, Hwang C, Healy MD, Whitcomb J, Lataillade M, Wind-Rotolo M, Krystal M, Hanna GJ.

J Acquir Immune Defic Syndr. 2013 Sep 1;64(1):7-15. doi: 10.1097/QAI.0b013e31829726f3.

PMID: 23614999

 

Development of a validated liquid chromatography tandem mass spectrometry assay for a PEGylated adnectin in cynomolgus monkey plasma using protein precipitation and trypsin digestion.

Dawes ML, Gu H, Wang J, Schuster AE, Haulenbeek J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:1-7. doi: 10.1016/j.jchromb.2013.06.027.

PMID: 23891912

 

The Discovery and Development of a Potent Antiviral Drug, Entecavir, for the Treatment of Chronic Hepatitis B.

Tang H, Griffin J, Innaimo S, Lehman-Mckeeman L, Llamoso C.

J Clin Transl Hepatol. 2013 Sep;1(1):51-8. doi: 10.14218/JCTH.2013.00006. Review.

PMID: 26357607

 

Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression.

Parker RA, Garcia R, Ryan CS, Liu X, Shipkova P, Livanov V, Patel P, Ho SP.

J Lipid Res. 2013 Sep;54(9):2400-9. doi: 10.1194/jlr.M038331.

PMID: 23614904

 

A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies.

Zheng N, Zeng J, Akinsanya B, Buzescu A, Xia YQ, Ly V, Trouba K, Peng Q, Aubry AF, Arnold ME.

J Pharm Biomed Anal. 2013 Sep;83:237-48. doi: 10.1016/j.jpba.2013.05.019.

PMID: 23770636

 

Investigation of monoclonal antibody fragmentation artifacts in non-reducing SDS-PAGE.

Zhu ZC, Chen Y, Ackerman MS, Wang B, Wu W, Li B, Obenauer-Kutner L, Zhao R, Tao L, Ihnat PM, Liu J, Gandhi RB, Qiu B.

J Pharm Biomed Anal. 2013 Sep;83:89-95. doi: 10.1016/j.jpba.2013.04.030.

PMID: 23708435

 

Semi-preparative LC-SPE-cryoflow NMR for impurity identifications: use of mother liquor as a better source of impurities.

Rinaldi F, Fan J, Pathirana C, Palaniswamy V.

Magn Reson Chem. 2013 Sep;51(9):517-22. doi: 10.1002/mrc.3979.

PMID: 23788325

 

Value-based assessment of pharmacodiagnostic testing from early stage development to real-world use.

Burns LC, Orsini L, L'italien G.

Value Health. 2013 Sep-Oct;16(6 Suppl):S16-9. doi: 10.1016/j.jval.2013.06.007.

PMID: 24034307

 

Personalized medicine and the role of health economics and outcomes research: issues, applications, emerging trends, and future research.

O'Donnell JC.

Value Health. 2013 Sep-Oct;16(6 Suppl):S1-3. doi: 10.1016/j.jval.2013.06.004.

PMID: 24034305

 

Characterizations of HCV NS5A replication complex inhibitors.

O'Boyle Ii DR, Sun JH, Nower PT, Lemm JA, Fridell RA, Wang C, Romine JL, Belema M, Nguyen VN, Laurent DR, Serrano-Wu M, Snyder LB, Meanwell NA, Langley DR, Gao M.

Virology. 2013 Sep;444(1-2):343-54. doi: 10.1016/j.virol.2013.06.032.

PMID: 23896639

 

Isolation and characterization of interferon lambda-resistant hepatitis C virus replicon cell lines.

Friborg J, Lin B, Chen C, McPhee F.

Virology. 2013 Sep;444(1-2):384-93. doi: 10.1016/j.virol.2013.07.005.

PMID: 23891156

 

Addressing the need for biomarker liquid chromatography/mass spectrometry assays: a protocol for effective method development for the bioanalysis of endogenous compounds in cerebrospinal fluid.

Benitex Y, McNaney CA, Luchetti D, Schaeffer E, Olah TV, Morgan DG, Drexler DM.

Rapid Commun Mass Spectrom. 2013 Aug 30;27(16):1882-6. doi: 10.1002/rcm.6639.

PMID: 23857934

 

Lewis base catalysis of the Mukaiyama directed aldol reaction: 40 years of inspiration and advances.

Beutner GL, Denmark SE.

Angew Chem Int Ed Engl. 2013 Aug 26;52(35):9086-96. doi: 10.1002/anie.201302084. Review.

PMID: 23843275

 

Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy.

Schweizer L, Zhang L.

Cancer Growth Metastasis. 2013 Aug 20;6:53-9. doi: 10.4137/CGM.S11134.

PMID: 24665207

 

HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.

Belema M, Nguyen VN, St Laurent DR, Lopez OD, Qiu Y, Good AC, Nower PT, Valera L, O'Boyle DR 2nd, Sun JH, Liu M, Fridell RA, Lemm JA, Gao M, Knipe JO, Meanwell NA, Snyder LB.

Bioorg Med Chem Lett. 2013 Aug 1;23(15):4428-35. doi: 10.1016/j.bmcl.2013.05.040.

PMID: 23803586

 

Clinically relevant reductions in HbA1c without hypoglycaemia: results across four studies of saxagliptin.

Karyekar CS, Frederich R, Ravichandran S.

Int J Clin Pract. 2013 Aug;67(8):759-67. doi: 10.1111/ijcp.12212.

PMID: 23795975

 

Utility of gastric-retained alginate gels to modulate pharmacokinetic profiles in rats.

Foster KA, Sun H, Fancher RM, Proszynski M, Dixon G, Ford K, Cornelius G, Gudmundsson OS, Hageman MJ.

J Pharm Sci. 2013 Aug;102(8):2440-9. doi: 10.1002/jps.23630.

PMID: 23744594

 

Application of a kosmotrope-based solubility assay to multiple protein therapeutic classes indicates broad use as a high-throughput screen for protein therapeutic aggregation propensity.

Yamniuk AP, Ditto N, Patel M, Dai J, Sejwal P, Stetsko P, Doyle ML.

J Pharm Sci. 2013 Aug;102(8):2424-39. doi: 10.1002/jps.23618.

PMID: 23712759

 

3D matched pairs: integrating ligand- and structure-based knowledge for ligand design and receptor annotation.

Posy SL, Claus BL, Pokross ME, Johnson SR.

J Chem Inf Model. 2013 Jul 22;53(7):1576-88. doi: 10.1021/ci400201k.

PMID: 23809058

 

Multicomponent synthesis of 1-aryl 1,2,4-triazoles.

Tam A, Armstrong IS, La Cruz TE.

Org Lett. 2013 Jul 19;15(14):3586-9. doi: 10.1021/ol401428x.

PMID: 23815306

 

Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex.

Kim SH, Constantine KL, Duke GJ, Goldfarb V, Hunt JT, Johnson S, Kish K, Klei HE, McDonnell PA, Metzler WJ, Mueller L, Poss MA, Fairchild CR, Bhide RS.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4107-11. doi: 10.1016/j.bmcl.2013.05.052.

PMID: 23747226

 

The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.

Wrobleski ST, Lin S, Dhar TG, Dyckman AJ, Li T, Pitt S, Zhang R, Fan Y, Doweyko AM, Tokarski JS, Kish KF, Kiefer SE, Sack JS, Newitt JA, Witmer MR, McKinnon M, Barrish JC, Dodd JH, Schieven GL, Leftheris K.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4120-6. doi: 10.1016/j.bmcl.2013.05.047.

PMID: 23746475

 

2-Aminothiazole based P2Y(1) antagonists as novel antiplatelet agents.

Pi Z, Sutton J, Lloyd J, Hua J, Price L, Wu Q, Chang M, Zheng J, Rehfuss R, Huang CS, Wexler RR, Lam PY.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4206-9. doi: 10.1016/j.bmcl.2013.05.025.

PMID: 23743287

 

Exposure-response relationships of the efficacy and safety of ipilimumab in patients with advanced melanoma.

Feng Y, Roy A, Masson E, Chen TT, Humphrey R, Weber JS.

Clin Cancer Res. 2013 Jul 15;19(14):3977-86. doi: 10.1158/1078-0432.CCR-12-3243.

PMID: 23741070

 

Factors influencing magnitude and duration of target inhibition following antibody therapy: implications in drug discovery and development.

Chimalakonda AP, Yadav R, Marathe P.

AAPS J. 2013 Jul;15(3):717-27. doi: 10.1208/s12248-013-9477-3.

PMID: 23588584

 

A comparison of the likelihood ratio test and the variance-stabilising transformation-based tests for detecting association of rare variants.

Xing G, Ku HC, Xing C.

Ann Hum Genet. 2013 Jul;77(4):333-5. doi: 10.1111/ahg.12022.

PMID: 23488943

 

Adverse events in patients with liver cancer.

Dreyfus B, Kawabata HM, Gomez-Caminero A.

Anticancer Drugs. 2013 Jul;24(6):630-5. doi: 10.1097/CAD.0b013e3283607f4f.

PMID: 23525070

 

Rapid development of multiple 'fit-for-purpose' assays on an automatic microfluidic system using a streamlined process in support of early biotherapeutics discovery programs.

Liu R, Pillutla R, DeSilva B, Zhang YJ.

Bioanalysis. 2013 Jul;5(14):1751-63. doi: 10.4155/bio.13.152.

PMID: 23862707

 

A generic template for automated bioanalytical ligand-binding assays using modular robotic scripts in support of discovery biotherapeutic programs.

Duo J, Dong H, DeSilva B, Zhang YJ.

Bioanalysis. 2013 Jul;5(14):1735-50. doi: 10.4155/bio.13.154.

PMID: 23862706

 

Sample reduction strategies in discovery bioanalysis.

Cai X, Zhang J, Shou WZ.

Bioanalysis. 2013 Jul;5(13):1691-701. doi: 10.4155/bio.13.133. Review.

PMID: 23822131

 

Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist.

Luo G, Chen L, Hu S, Huang Y, Mattson G, Iben LG, Russell JW, Clarke WJ, Hogan JB, Antal-Zimanyi I, Poindexter GS.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3814-7. doi: 10.1016/j.bmcl.2013.04.095.

PMID: 23726344

 

The discovery of BMS-457, a potent and selective CCR1 antagonist.

Gardner DS, Santella JB 3rd, Duncia JV, Carter PH, Dhar TG, Wu H, Guo W, Cavallaro C, Van Kirk K, Yarde M, Briceno SW, Grafstrom RR, Liu R, Patel SR, Tebben AJ, Camac D, Khan J, Watson A, Yang G, Rose A, Foster WR, Cvijic ME, Davies P, Hynes J Jr.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3833-40. doi: 10.1016/j.bmcl.2013.04.079.

PMID: 23707259

  

Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.

Zhao G, Kwon C, Bisaha SN, Stein PD, Rossi KA, Cao X, Ung T, Wu G, Hung CP, Malmstrom SE, Zhang G, Qu Q, Gan J, Keim WJ, Cullen MJ, Rohrbach KW, Devenny J, Pelleymounter MA, Miller KJ, Robl JA.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3914-9. doi: 10.1016/j.bmcl.2013.04.061.

PMID: 23683593

 

Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells.

Selby MJ, Engelhardt JJ, Quigley M, Henning KA, Chen T, Srinivasan M, Korman AJ.

Cancer Immunol Res. 2013 Jul;1(1):32-42. doi: 10.1158/2326-6066.CIR-13-0013.

PMID: 24777248

 

A new perspective on the mechanical evaluation of granular material.

Chan SH, Wang SS, Lai C, Grosso J.

Drug Dev Ind Pharm. 2013 Jul;39(7):1126-32. doi: 10.3109/03639045.2012.715353.

PMID: 22934612

 

Characterization of recombinantly expressed rat and monkey intestinal alkaline phosphatases: in vitro studies and in vivo correlations.

Subramanian M, Paruchury S, Singh Gautam S, Pratap Singh S, Arla R, Pahwa S, Jana S, Katnapally P, Yoganand V, Lakshmaiah B, Mazumder Tagore D, Ghosh K, Marathe P, Mandlekar S.

Drug Metab Dispos. 2013 Jul;41(7):1425-32. doi: 10.1124/dmd.113.051987.

PMID: 23633529

 

Apixaban in the prevention of stroke and systemic embolism in nonvalvular atrial fibrillation.

Pujadas-Mestres L, Escolar G, Arellano-Rodrigo E, Galán AM.

Drugs Today (Barc). 2013 Jul;49(7):425-36. doi: 10.1358/dot.2013.49.7.1980498. Review.

PMID: 23914351

 

The synthesis of a carbon-14 labeled pegylated Adnectin™ for placental transfer studies in guinea pigs.

Maxwell BD, Cao K, Bonacorsi S, Sivaraman L, Wang B, McNerney M, Wang L, Christopher LJ, Fung NK, Wang J, Arnold ME.

J Labelled Comp Radiopharm. 2013 Jul-Aug;56(9-10):492-4. doi: 10.1002/jlcr.3077.

PMID: 24285527

 

Interleukin-21 enhances rituximab activity in a cynomolgus monkey model of B cell depletion and in mouse B cell lymphoma models.

Krejsa CM, Holly RD, Heipel M, Bannink KM, Johnson R, Roque R, Heffernan J, Hill J, Chin L, Wagener F, Shiota F, Henderson K, Sivakumar PV, Ren HP, Barahmand-Pour F, Foster D, Clegg C, Kindsvogel W, Ponce R, Hughes SD, Waggie K.

PLoS One. 2013 Jun 25;8(6):e67256. doi: 10.1371/journal.pone.0067256.

PMID: 23825648

 

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor.

Burford NT, Clark MJ, Wehrman TS, Gerritz SW, Banks M, O'Connell J, Traynor JR, Alt A.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10830-5. doi: 10.1073/pnas.1300393110.

PMID: 23754417

 

New azole antagonists with high affinity for the P2Y(1) receptor.

Ruel R, L'Heureux A, Thibeault C, Daris JP, Martel A, Price LA, Wu Q, Hua J, Wexler RR, Rehfuss R, Lam PY.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3519-22. doi: 10.1016/j.bmcl.2013.04.041.

PMID: 23668989

 

Differential effects of dosing regimen on the safety and efficacy of dasatinib: retrospective exposure-response analysis of a Phase III study.

Wang X, Roy A, Hochhaus A, Kantarjian HM, Chen TT, Shah NP.

Clin Pharmacol. 2013 Jun 10;5:85-97. doi: 10.2147/CPAA.S42796.

PMID: 23788844

 

Validation of companion diagnostic for detection of mutations in codons 12 and 13 of the KRAS gene in patients with metastatic colorectal cancer: analysis of the NCIC CTG CO.17 trial.

Harbison CT, Horak CE, Ledeine JM, Mukhopadhyay P, Malone DP, O'Callaghan C, Jonker DJ, Karapetis CS, Khambata-Ford S, Gustafson N, Trifan OC, Chang SC, Ravetto P, Iv GA.

Arch Pathol Lab Med. 2013 Jun;137(6):820-7. doi: 10.5858/arpa.2012-0367-OA.

PMID: 23030695

 

Dual universal peptide approach to bioanalysis of human monoclonal antibody protein drug candidates in animal studies.

Furlong MT, Zhao S, Mylott W, Jenkins R, Gao M, Hegde V, Tamura J, Tymiak A, Jemal M.

Bioanalysis. 2013 Jun;5(11):1363-76. doi: 10.4155/bio.13.55.

PMID: 23742306

 

Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.

Chaturvedula PV, Mercer SE, Pin SS, Thalody G, Xu C, Conway CM, Keavy D, Signor L, Cantor GH, Mathias N, Moench P, Denton R, Macci R, Schartman R, Whiterock V, Davis C, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3157-61. doi: 10.1016/j.bmcl.2013.04.012.

PMID: 23632269

 

Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility.

Wang TC, Qiao JX, Clark CG, Jua J, Price LA, Wu Q, Chang M, Zheng J, Huang CS, Everlof G, Schumacher WA, Wong PC, Seiffert DA, Stewart AB, Bostwick JS, Crain EJ, Watson CA, Rehfuss R, Wexler RR, Lam PY.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3239-43. doi: 10.1016/j.bmcl.2013.03.125.

PMID: 23602442

 

Compartmental absorption modeling and site of absorption studies to determine feasibility of an extended-release formulation of an HIV-1 attachment inhibitor phosphate ester prodrug.

Brown J, Chien C, Timmins P, Dennis A, Doll W, Sandefer E, Page R, Nettles RE, Zhu L, Grasela D.

J Pharm Sci. 2013 Jun;102(6):1742-51. doi: 10.1002/jps.23476.

PMID: 23681563

 

FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.

Conrad W, Major MB, Cleary MA, Ferrer M, Roberts B, Marine S, Chung N, Arthur WT, Moon RT, Berndt JD, Chien AJ.

Version 2. F1000Res. 2013 May 31 [revised 2013 Jan 1];2:134. doi: 10.12688/f1000research.2-134.v2.

PMID: 24358901

 

The impact of palladium(II) reduction pathways on the structure and activity of palladium(0) catalysts.

Wei CS, Davies GH, Soltani O, Albrecht J, Gao Q, Pathirana C, Hsiao Y, Tummala S, Eastgate MD.

Angew Chem Int Ed Engl. 2013 May 27;52(22):5822-6. doi: 10.1002/anie.201210252. No abstract available.

PMID: 23610043

 

A randomized, double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infection.

Gardiner D, Lalezari J, Lawitz E, DiMicco M, Ghalib R, Reddy KR, Chang KM, Sulkowski M, Marro SO, Anderson J, He B, Kansra V, McPhee F, Wind-Rotolo M, Grasela D, Selby M, Korman AJ, Lowy I.

PLoS One. 2013 May 22;8(5):e63818. doi: 10.1371/journal.pone.0063818.

PMID: 23717490

 

Conformationally restricted homotryptamines. Part 6: indole-5-cycloalkyl methylamines as selective serotonin reuptake inhibitors.

Ditta JL, Denhart DJ, Deskus JA, Epperson JR, Meng Z, Gao Q, Mattson GK, Lapaglia MA, Taber MT, Molski TF, Lodge NJ, Mattson RJ, Macor JE.

Bioorg Med Chem Lett. 2013 May 15;23(10):2948-50. doi: 10.1016/j.bmcl.2013.03.045.

PMID: 23578689

 

Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor.

Liu C, Lin J, Everlof G, Gesenberg C, Zhang H, Marathe PH, Malley M, Galella MA, McKinnon M, Dodd JH, Barrish JC, Schieven GL, Leftheris K.

Bioorg Med Chem Lett. 2013 May 15;23(10):3028-33. doi: 10.1016/j.bmcl.2013.03.022.

PMID: 23578688

 

Characterization of disulfide linkages in recombinant human granulocyte-colony stimulating factor.

Mo J, Tymiak AA, Chen G.

Rapid Commun Mass Spectrom. 2013 May 15;27(9):940-6. doi: 10.1002/rcm.6530.

PMID: 23592195

 

Comparison of supercritical fluid chromatography and reverse phase liquid chromatography for the impurity profiling of the antiretroviral drugs lamivudine/BMS-986001/efavirenz in a combination tablet.

Alexander AJ, Zhang L, Hooker TF, Tomasella FP.

J Pharm Biomed Anal. 2013 May 5;78-79:243-51. doi: 10.1016/j.jpba.2013.02.019.

PMID: 23507686

 

Persistence of resistant variants in hepatitis C virus-infected patients treated with the NS5A replication complex inhibitor daclatasvir.

Wang C, Sun JH, O'Boyle DR 2nd, Nower P, Valera L, Roberts S, Fridell RA, Gao M.

Antimicrob Agents Chemother. 2013 May;57(5):2054-65. doi: 10.1128/AAC.02494-12.

PMID: 23403428

 

High-resolution MS for structural characterization of protein therapeutics: advances and future directions.

Wei H, Tymiak AA, Chen G.

Bioanalysis. 2013 May;5(10):1299-313. doi: 10.4155/bio.13.80. Review.

PMID: 23721450

 

High-resolution MS in regulated bioanalysis: where are we now and where do we go from here?

Fung EN, Jemal M, Aubry AF.

Bioanalysis. 2013 May;5(10):1277-84. doi: 10.4155/bio.13.81.

PMID: 23721448

 

Expedient data mining for nontargeted high-resolution LC-MS profiles of biological samples.

Hnatyshyn S, Shipkova P, Sanders M.

Bioanalysis. 2013 May;5(10):1195-210. doi: 10.4155/bio.13.86.

PMID: 23721443

 

Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications.

Thevanayagam L, Bell A, Chakraborty I, Sufi B, Gangwar S, Zang A, Rangan V, Rao C, Wang Z, Pan C, Chong C, Cardarelli P, Deshpande S, Srinivasan M.

Bioanalysis. 2013 May;5(9):1073-81. doi: 10.4155/bio.13.57.

PMID: 23641697

  

Bioequivalence of saxagliptin/metformin immediate release (IR) fixed-dose combination tablets and single-component saxagliptin and metformin IR tablets in healthy adult subjects.

Upreti VV, Keung CF, Boulton DW, Chang M, Li L, Tang A, Hsiang BC, Quamina-Edghill D, Frevert EU, Lacreta FP.

Clin Drug Investig. 2013 May;33(5):365-74. doi: 10.1007/s40261-013-0075-z.

PMID: 23549864

 

Progress in the discovery of CC chemokine receptor 2 antagonists, 2009 - 2012.

Carter PH.

Expert Opin Ther Pat. 2013 May;23(5):549-68. doi: 10.1517/13543776.2013.771168. Review.

PMID: 23428142

 

A validated HPLC-MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: application to a clinical pharmacokinetic study.

Furlong MT, Savant I, Yuan M, Scott L, Mylott W, Mariannino T, Kadiyala P, Roongta V, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 1;926:36-41. doi: 10.1016/j.jchromb.2013.02.031.

PMID: 23542721

 

Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors.

Hernandez D, Zhou N, Ueland J, Monikowski A, McPhee F.

J Clin Virol. 2013 May;57(1):13-8. doi: 10.1016/j.jcv.2012.12.020. Erratum in: J Clin Virol. 2016 Apr;77:115.

PMID: 23384816

 

Effects of dapagliflozin on cardiovascular risk factors.

Ptaszynska A, Hardy E, Johnsson E, Parikh S, List J.

Postgrad Med. 2013 May;125(3):181-9. doi: 10.3810/pgm.2013.05.2667. Review.

PMID: 23748519

 

Effect of famotidine on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor.

Upreti VV, Song Y, Wang J, Byon W, Boyd RA, Pursley JM, Lacreta F, Frost CE.

Clin Pharmacol. 2013 Apr 16;5:59-66. doi: 10.2147/CPAA.S41999.

PMID: 23637566

 

Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.

Wu YJ, He H, Bertekap R, Westphal R, Lelas S, Newton A, Wallace T, Taber M, Davis C, Macor JE, Bronson J.

Bioorg Med Chem. 2013 Apr 15;21(8):2217-28. doi: 10.1016/j.bmc.2013.02.010.

PMID: 23477943

 

Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.

Priestley ES, De Lucca I, Zhou J, Zhou J, Saiah E, Stanton R, Robinson L, Luettgen JM, Wei A, Wen X, Knabb RM, Wong PC, Wexler RR.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2432-5. doi: 10.1016/j.bmcl.2013.02.013.

PMID: 23478148

 

A high-speed liquid chromatography/tandem mass spectrometry platform using multiplexed multiple-injection chromatography controlled by single software and its application in discovery ADME screening.

Zhang J, Vath M, Ferraro C, Li Y, Murphy K, Zvyaga T, Weller H, Shou W.

Rapid Commun Mass Spectrom. 2013 Apr 15;27(7):731-7. doi: 10.1002/rcm.6514.

PMID: 23495019

 

Liquid chromatography coupled with tandem mass spectrometry for the bioanalysis of proteins in drug development: practical considerations in assay development and validation.

Liu G, Ji QC, Dodge R, Sun H, Shuster D, Zhao Q, Arnold M.

J Chromatogr A. 2013 Apr 5;1284:155-62. doi: 10.1016/j.chroma.2013.02.016.

PMID: 23466204

 

Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones.

Denhart DJ, Zuev D, Ditta JL, Hartz RA, Ahuja VT, Mattson RJ, Huang H, Mattson GK, Zueva L, Nielsen JM, Kozlowski ES, Lodge NJ, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2052-5. doi: 10.1016/j.bmcl.2013.02.009.

PMID: 23465610

 

Selected adverse events in cancer patients treated with vascular endothelial growth factor inhibitors.

Dreyfus B, Kawabata H, Gomez A.

Cancer Epidemiol. 2013 Apr;37(2):191-6. doi: 10.1016/j.canep.2012.11.001.

PMID: 23246035

 

Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats.

Zhang D, Frost CE, He K, Rodrigues AD, Wang X, Wang L, Goosen TC, Humphreys WG.

Drug Metab Dispos. 2013 Apr;41(4):906-15. doi: 10.1124/dmd.112.050575.

PMID: 23386703

 

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Zhang D, He K, Herbst JJ, Kolb J, Shou W, Wang L, Balimane PV, Han YH, Gan J, Frost CE, Humphreys WG.

Drug Metab Dispos. 2013 Apr;41(4):827-35. doi: 10.1124/dmd.112.050260.

PMID: 23382458

 

 Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus.

Washburn WN, Poucher SM.

Expert Opin Investig Drugs. 2013 Apr;22(4):463-86. doi: 10.1517/13543784.2013.774372. Review.

PMID: 23452053

 

Pharmacological and behavioral characterization of the novel CRF1 antagonist BMS-763534.

Lodge NJ, Lelas S, Li YW, Molski T, Grace J, Sivarao DV, Post-Munson D, Healy F, Bronson JJ, Hartz R, Macor JE, Zaczek R.

Neuropharmacology. 2013 Apr;67:284-93. doi: 10.1016/j.neuropharm.2012.10.025.

PMID: 23174340

 

Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.

Zhao G, Kwon C, Wang A, Robertson JG, Marcinkeviciene J, Parker RA, Kirby MS, Hamann LG.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1622-5. doi: 10.1016/j.bmcl.2013.01.104.

PMID: 23416006

 

Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors.

Zhang X, Glunz PW, Jiang W, Schmitt A, Newman M, Barbera FA, Bozarth JM, Rendina AR, Wei A, Wen X, Rossi KA, Luettgen JM, Wong PC, Knabb RM, Wexler RR, Scott Priestley E.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1604-7. doi: 10.1016/j.bmcl.2013.01.094.

PMID: 23416003

 

Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists.

McDonald IM, Mate RA, Zusi FC, Huang H, Post-Munson DJ, Ferrante MA, Gallagher L, Bertekap RL Jr, Knox RJ, Robertson BJ, Harden DG, Morgan DG, Lodge NJ, Dworetzky SI, Olson RE, Macor JE.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1684-8. doi: 10.1016/j.bmcl.2013.01.070.

PMID: 23414838

 

Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.

Finlay HJ, Jiang J, Caringal Y, Kover A, Conder ML, Xing D, Levesque P, Harper T, Hsueh MM, Atwal K, Blanar M, Wexler R, Lloyd J.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1743-7. doi: 10.1016/j.bmcl.2013.01.064.

PMID: 23414837

 

The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.

Han X, Civiello RL, Conway CM, Cook DA, Davis CD, Degnan AP, Jiang XJ, Macci R, Mathias NR, Moench P, Pin SS, Schartman R, Signor LJ, Thalody G, Tora G, Whiterock V, Xu C, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1870-3. doi: 10.1016/j.bmcl.2013.01.011. Erratum in: Bioorg Med Chem Lett. 2013 Jun 15;23(12):3674.

PMID: 23402880

 

Biomarker analysis of neoadjuvant doxorubicin/cyclophosphamide followed by ixabepilone or Paclitaxel in early-stage breast cancer.

Horak CE, Pusztai L, Xing G, Trifan OC, Saura C, Tseng LM, Chan S, Welcher R, Liu D.

Clin Cancer Res. 2013 Mar 15;19(6):1587-95. doi: 10.1158/1078-0432.CCR-12-1359.

PMID: 23340299

 

Effects of column back pressure on supercritical fluid chromatography separations of enantiomers using binary mobile phases on 10 chiral stationary phases.

Wang C, Zhang Y.

J Chromatogr A. 2013 Mar 15;1281:127-34. doi: 10.1016/j.chroma.2013.01.050.

PMID: 23394748

 

A rugged and accurate liquid chromatography-tandem mass spectrometry method for the determination of asunaprevir, an NS3 protease inhibitor, in plasma.

Yuan L, Jiang H, Ouyang Z, Xia YQ, Zeng J, Peng Q, Lange RW, Deng Y, Arnold ME, Aubry AF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Mar 15;921-922:81-6. doi: 10.1016/j.jchromb.2013.01.029.

PMID: 23435345

 

A simplified and completely automated workflow for regulated LC-MS/MS bioanalysis using cap-piercing direct sampling and evaporation-free solid phase extraction.

Zheng N, Buzescu A, Pasas-Farmer S, Arnold ME, Ouyang Z, Jemal M, Peng Q, Van Vleet T, Zeng J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Mar 15;921-922:64-74. doi: 10.1016/j.jchromb.2013.01.028.

PMID: 23435343

 

Investigating the applicability of inverse gas chromatography to binary powdered systems: an application of surface heterogeneity profiles to understanding preferential probe-surface interactions.

Gamble JF, Davé RN, Kiang S, Leane MM, Tobyn M, Wang SS.

Int J Pharm. 2013 Mar 10;445(1-2):39-46. doi: 10.1016/j.ijpharm.2013.01.061.

PMID: 23380622

 

Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype.

Lane RM, He Y.

Alzheimers Dement. 2013 Mar;9(2):e1-73. doi: 10.1016/j.jalz.2010.12.005. Review.

PMID: 22402324

 

Combinations of lambda interferon with direct-acting antiviral agents are highly efficient in suppressing hepatitis C virus replication.

Friborg J, Levine S, Chen C, Sheaffer AK, Chaniewski S, Voss S, Lemm JA, McPhee F.

Antimicrob Agents Chemother. 2013 Mar;57(3):1312-22. doi: 10.1128/AAC.02239-12.

PMID: 23274666

 

Simultaneous oral therapeutic and intravenous ¹⁴C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin.

Boulton DW, Kasichayanula S, Keung CF, Arnold ME, Christopher LJ, Xu XS, Lacreta F.

Br J Clin Pharmacol. 2013 Mar;75(3):763-8. doi: 10.1111/j.1365-2125.2012.04391.x.

PMID: 22823746

 

Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.

Bain G, King CD, Schaab K, Rewolinski M, Norris V, Ambery C, Bentley J, Yamada M, Santini AM, van de Wetering de Rooij J, Stock N, Zunic J, Hutchinson JH, Evans JF.

Br J Clin Pharmacol. 2013 Mar;75(3):779-90. doi: 10.1111/j.1365-2125.2012.04386.x.

PMID: 22803688

 

Insight into tissue unbound concentration: utility in drug discovery and development.

Mariappan TT, Mandlekar S, Marathe P.

Curr Drug Metab. 2013 Mar;14(3):324-40. Review.

PMID: 23167621

 

Effects of rifampin and mefenamic acid on the pharmacokinetics and pharmacodynamics of dapagliflozin.

Kasichayanula S, Liu X, Griffen SC, Lacreta FP, Boulton DW.

Diabetes Obes Metab. 2013 Mar;15(3):280-3. doi: 10.1111/dom.12024.

PMID: 23061428

 

Dosing patterns of aripiprazole and quetiapine for adjunctive treatment of major depressive disorder (2006-2010).

Jing Y, Guo Z, Kalsekar I, Forbes RA, Hebden T, Thase ME.

Int Clin Psychopharmacol. 2013 Mar;28(2):87-90. doi: 10.1097/YIC.0b013e32835ce232.

PMID: 23262644

 

Cynomolgus monkey as a potential model to assess drug interactions involving hepatic organic anion transporting polypeptides: in vitro, in vivo, and in vitro-to-in vivo extrapolation.

Shen H, Yang Z, Mintier G, Han YH, Chen C, Balimane P, Jemal M, Zhao W, Zhang R, Kallipatti S, Selvam S, Sukrutharaj S, Krishnamurthy P, Marathe P, Rodrigues AD.

J Pharmacol Exp Ther. 2013 Mar;344(3):673-85. doi: 10.1124/jpet.112.200691.

PMID: 23297161

 

Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.

Albright CF, Dockens RC, Meredith JE Jr, Olson RE, Slemmon R, Lentz KA, Wang JS, Denton RR, Pilcher G, Rhyne PW, Raybon JJ, Barten DM, Burton C, Toyn JH, Sankaranarayanan S, Polson C, Guss V, White R, Simutis F, Sanderson T, Gillman KW, Starrett JE Jr, Bronson J, Sverdlov O, Huang SP, Castaneda L, Feldman H, Coric V, Zaczek R, Macor JE, Houston J, Berman RM, Tong G.

J Pharmacol Exp Ther. 2013 Mar;344(3):686-95. doi: 10.1124/jpet.112.199356.

PMID: 23275065

 

Formulation and process design for a solid dosage form containing a spray-dried amorphous dispersion of ibipinabant.

Leane MM, Sinclair W, Qian F, Haddadin R, Brown A, Tobyn M, Dennis AB.

Pharm Dev Technol. 2013 Mar-Apr;18(2):359-66. doi: 10.3109/10837450.2011.619544.

PMID: 22268601

 

Pharmacokinetics and pharmacodynamics of atazanavir-containing antiretroviral regimens, with or without ritonavir, in patients who are HIV-positive and treatment-naïve.

Bertz RJ, Persson A, Chung E, Zhu L, Zhang J, McGrath D, Grasela D.

Pharmacotherapy. 2013 Mar;33(3):284-94. doi: 10.1002/phar.1205.

PMID: 23456732

 

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248.

Regueiro-Ren A, Simmermacher-Mayer J, Sinz M, Johnson KA, Huang XS, Jenkins S, Parker D, Rahematpura S, Zheng M, Meanwell NA, Kadow JF.

J Med Chem. 2013 Feb 28;56(4):1670-6. doi: 10.1021/jm301638a.

PMID: 23374053

 

Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.

Chao H, Turdi H, Herpin TF, Roberge JY, Liu Y, Schnur DM, Poss MA, Rehfuss R, Hua J, Wu Q, Price LA, Abell LM, Schumacher WA, Bostwick JS, Steinbacher TE, Stewart AB, Ogletree ML, Huang CS, Chang M, Cacace AM, Arcuri MJ, Celani D, Wexler RR, Lawrence RM.

J Med Chem. 2013 Feb 28;56(4):1704-14. doi: 10.1021/jm301708u.

PMID: 23368907

 

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1h-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-585248).

Regueiro-Ren A, Xue QM, Swidorski JJ, Gong YF, Mathew M, Parker DD, Yang Z, Eggers B, D'Arienzo C, Sun Y, Malinowski J, Gao Q, Wu D, Langley DR, Colonno RJ, Chien C, Grasela DM, Zheng M, Lin PF, Meanwell NA, Kadow JF.

J Med Chem. 2013 Feb 28;56(4):1656-69. doi: 10.1021/jm3016377.

PMID: 23360431

 

Improved ruggedness of an ion-pairing liquid chromatography/tandem mass spectrometry assay for the quantitative analysis of the triphosphate metabolite of a nucleoside reverse transcriptase inhibitor in peripheral blood mononuclear cells.

Zhao Y, Liu G, Liu Y, Yuan L, Hawthorne D, Shen JX, Guha M, Aubry A.

Rapid Commun Mass Spectrom. 2013 Feb 15;27(3):481-8. doi: 10.1002/rcm.6473.

PMID: 23280981

 

HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies.

Lopez OD, Nguyen VN, St Laurent DR, Belema M, Serrano-Wu MH, Goodrich JT, Yang F, Qiu Y, Ripka AS, Nower PT, Valera L, Liu M, O'Boyle DR 2nd, Sun JH, Fridell RA, Lemm JA, Gao M, Good AC, Meanwell NA, Snyder LB.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):779-84. doi: 10.1016/j.bmcl.2012.11.086.

PMID: 23273521

 

Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects.

Frost C, Wang J, Nepal S, Schuster A, Barrett YC, Mosqueda-Garcia R, Reeves RA, LaCreta F.

Br J Clin Pharmacol. 2013 Feb;75(2):476-87. doi: 10.1111/j.1365-2125.2012.04369.x.

PMID: 22759198

 

Comparison of vascular leak syndrome in mice treated with IL21 or IL2.

Sivakumar PV, Garcia R, Waggie KS, Anderson-Haley M, Nelson A, Hughes SD.

Comp Med. 2013 Feb;63(1):13-21.

PMID: 23561933

 

Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.

Sinz MW.

Drug Metab Rev. 2013 Feb;45(1):3-14. doi: 10.3109/03602532.2012.743560. Review.

PMID: 23330538

 

Inhibitory effect of apixaban compared with rivaroxaban and dabigatran on thrombin generation assay.

Wong PC, White A, Luettgen J.

Hosp Pract (1995). 2013 Feb;41(1):19-25. doi: 10.3810/hp.2013.02.1009.

PMID: 23466964

 

Inhibitory effect of ketoconazole on the pharmacokinetics of a multireceptor tyrosine kinase inhibitor BMS-690514 in healthy participants: assessing the mechanism of the interaction with physiologically-based pharmacokinetic simulations.

Yang Z, Vakkalagadda B, Shen G, Ahlers CM, Has T, Christopher LJ, Kurland JF, Roongta V, Masson E, Zhang S.

J Clin Pharmacol. 2013 Feb;53(2):217-27. doi: 10.1177/0091270012439208.

PMID: 23436267

 

Real-time monitoring of thermodynamic microenvironment in a pan coater.

Pandey P, Bindra DS.

J Pharm Sci. 2013 Feb;102(2):336-40. doi: 10.1002/jps.23379.

PMID: 23161333

 

Intragenic complementation of hepatitis C virus NS5A RNA replication-defective alleles.

Fridell RA, Valera L, Qiu D, Kirk MJ, Wang C, Gao M.

J Virol. 2013 Feb;87(4):2320-9. doi: 10.1128/JVI.02861-12.

PMID: 23236071

 

Processing challenges with solid dosage formulations containing vitamin E TPGS.

Pandey P, Sinko PD, Bindra DS, Hamey R, Gour S, Vema-Varapu C.

Pharm Dev Technol. 2013 Feb;18(1):296-304. doi: 10.3109/10837450.2012.737807.

PMID: 23136832

 

A combined experimental and modeling approach to study the effects of high-shear wet granulation process parameters on granule characteristics.

Pandey P, Tao J, Chaudhury A, Ramachandran R, Gao JZ, Bindra DS.

Pharm Dev Technol. 2013 Feb;18(1):210-24. doi: 10.3109/10837450.2012.700933.

PMID: 22780851

 

Establishment of a molecular embryonic stem cell developmental toxicity assay.

Panzica-Kelly JM, Brannen KC, Ma Y, Zhang CX, Flint OP, Lehman-McKeeman LD, Augustine-Rauch KA.

Toxicol Sci. 2013 Feb;131(2):447-57. doi: 10.1093/toxsci/kfs293.

PMID: 23042729

 

Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.

Gillman KW, Parker MF, Silva M, Degnan AP, Tora GO, Lodge NJ, Li YW, Lelas S, Taber M, Krause RG, Bertekap RL, Newton AE, Pieschl RL, Lengyel KD, Johnson KA, Taylor SJ, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2013 Jan 15;23(2):407-11. doi: 10.1016/j.bmcl.2012.11.094.

PMID: 23253443

 

BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies.

Kuhne MR, Mulvey T, Belanger B, Chen S, Pan C, Chong C, Cao F, Niekro W, Kempe T, Henning KA, Cohen LJ, Korman AJ, Cardarelli PM.

Clin Cancer Res. 2013 Jan 15;19(2):357-66. doi: 10.1158/1078-0432.CCR-12-2333.

PMID: 23213054

 

Comparison of chromatographic techniques for diastereomer separation of a diverse set of drug-like compounds.

Ebinger K, Weller HN.

J Chromatogr A. 2013 Jan 11;1272:150-4. doi: 10.1016/j.chroma.2012.11.065.

PMID: 23261288

 

In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A.

Wang C, Valera L, Jia L, Kirk MJ, Gao M, Fridell RA.

Antimicrob Agents Chemother. 2013 Jan;57(1):611-3. doi: 10.1128/AAC.01874-12.

PMID: 23089758

 

Assessment of pharmacokinetic interactions of the HCV NS5A replication complex inhibitor daclatasvir with antiretroviral agents: ritonavir-boosted atazanavir, efavirenz and tenofovir.

Bifano M, Hwang C, Oosterhuis B, Hartstra J, Grasela D, Tiessen R, Velinova-Donga M, Kandoussi H, Sevinsky H, Bertz R.

Antivir Ther. 2013;18(7):931-40. doi: 10.3851/IMP2674.

PMID: 23963204

 

Atazanavir pharmacokinetics, efficacy and safety in pregnancy: a systematic review.

Eley T, Bertz R, Hardy H, Burger D.

Antivir Ther. 2013;18(3):361-75. doi: 10.3851/IMP2473. Review.

PMID: 23676668

 

Fit-for-purpose bioanalytical cross-validation for LC-MS/MS assays in clinical studies.

Xu X, Ji QC, Jemal M, Gleason C, Shen JX, Stouffer B, Arnold ME.

Bioanalysis. 2013 Jan;5(1):83-90. doi: 10.4155/bio.12.291.

PMID: 23256474

 

Establishment of a robust hepatitis C virus replicon cell line over-expressing P-glycoprotein that facilitates analysis of P-gp drug transporter effects on inhibitor antiviral activity.

Hernandez D, Falk P, Yu F, Zhai G, Quan Y, Faria T, Cao K, Scola P, McPhee F.

Biochem Pharmacol. 2013 Jan 1;85(1):21-8. doi: 10.1016/j.bcp.2012.10.002.

PMID: 23063413

 

Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores.

Bender JA, Yang Z, Eggers B, Gong YF, Lin PF, Parker DD, Rahematpura S, Zheng M, Meanwell NA, Kadow JF.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):218-22. doi: 10.1016/j.bmcl.2012.10.118.

PMID: 23206859

 

Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.

Wang T, Yang Z, Zhang Z, Gong YF, Riccardi KA, Lin PF, Parker DD, Rahematpura S, Mathew M, Zheng M, Meanwell NA, Kadow JF, Bender JA.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):213-7. doi: 10.1016/j.bmcl.2012.10.120.

PMID: 23200254

 

Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.

Yeung KS, Qiu Z, Xue Q, Fang H, Yang Z, Zadjura L, D'Arienzo CJ, Eggers BJ, Riccardi K, Shi PY, Gong YF, Browning MR, Gao Q, Hansel S, Santone K, Lin PF, Meanwell NA, Kadow JF.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):198-202. doi: 10.1016/j.bmcl.2012.10.115.

PMID: 23200252

 

Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.

Yeung KS, Qiu Z, Yin Z, Trehan A, Fang H, Pearce B, Yang Z, Zadjura L, D'Arienzo CJ, Riccardi K, Shi PY, Spicer TP, Gong YF, Browning MR, Hansel S, Santone K, Barker J, Coulter T, Lin PF, Meanwell NA, Kadow JF.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):203-8. doi: 10.1016/j.bmcl.2012.10.117.

PMID: 23200249

 

Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.

Yeung KS, Qiu Z, Yang Z, Zadjura L, D'Arienzo CJ, Browning MR, Hansel S, Huang XS, Eggers BJ, Riccardi K, Lin PF, Meanwell NA, Kadow JF.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):209-12. doi: 10.1016/j.bmcl.2012.10.125.

PMID: 23200244

 

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.

Fevig JM, Feng J, Rossi KA, Miller KJ, Wu G, Hung CP, Ung T, Malmstrom SE, Zhang G, Keim WJ, Cullen MJ, Rohrbach KW, Qu Q, Gan J, Pelleymounter MA, Robl JA.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):330-5. doi: 10.1016/j.bmcl.2012.10.091.

PMID: 23177783

 

A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat.

Tong G, Wang JS, Sverdlov O, Huang SP, Slemmon R, Croop R, Castaneda L, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Dockens R.

Br J Clin Pharmacol. 2013 Jan;75(1):136-45. doi: 10.1111/j.1365-2125.2012.04339.x.

PMID: 22616739

 

CTLA-4 blockade in tumor models: an overview of preclinical and translational research.

Grosso JF, Jure-Kunkel MN.

Cancer Immun. 2013;13:5. Review.

PMID: 23390376

 

Tolerability and efficacy of glycemic control with saxagliptin in older patients (aged ≥ 65 years) with inadequately controlled type 2 diabetes mellitus.

Karyekar CS, Ravichandran S, Allen E, Fleming D, Frederich R.

Clin Interv Aging. 2013;8:419-30. doi: 10.2147/CIA.S41246.

PMID: 23626461

 

Medical costs and utilization in patients with depression treated with adjunctive atypical antipsychotic therapy.

Nadkarni A, Kalsekar I, You M, Forbes R, Hebden T.

Clinicoecon Outcomes Res. 2013;5:49-57. doi: 10.2147/CEOR.S36526.

PMID: 23378778

 

Determination of relative Notch1 and gamma-secretase-related gene expression in puromycin-treated microdissected rat kidneys.

Simic D, Simutis F, Euler C, Thurby C, Peden WM, Bunch RT, Pilcher G, Sanderson T, Van Vleet T.

Gene Expr. 2013;16(1):39-47.

PMID: 24397211

 

γ -Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?

Toyn JH, Rowley A, Matsuoka Y, Tomita T, Imbimbo BP.

Int J Alzheimers Dis. 2013;2013:849128. doi: 10.1155/2013/849128. No abstract available.

PMID: 23710414

 

Methods: implementation of in vitro and ex vivo phagocytosis and respiratory burst function assessments in safety testing.

Freebern WJ, Bigwarfe TJ, Price KD, Haggerty HG.

J Immunotoxicol. 2013 Jan-Mar;10(1):106-17. doi: 10.3109/1547691X.2012.736427.

PMID: 23173903

 

The rat whole embryo culture assay using the Dysmorphology Score system.

Zhang C, Panzica-Kelly J, Augustine-Rauch K.

Methods Mol Biol. 2013;947:423-50. doi: 10.1007/978-1-62703-131-8_30.

PMID: 23138920

 

11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice.

García RA, Search DJ, Lupisella JA, Ostrowski J, Guan B, Chen J, Yang WP, Truong A, He A, Zhang R, Yan M, Hellings SE, Gargalovic PS, Ryan CS, Watson LM, Langish RA, Shipkova PA, Carson NL, Taylor JR, Yang R, Psaltis GC, Harrity TW, Robl JA, Gordon DA.

PLoS One. 2013;8(2):e53192. doi: 10.1371/journal.pone.0053192.

PMID: 23383297

 

Mutations in the hedgehog pathway genes SMO and PTCH1 in human gastric tumors.

Wang XD, Inzunza H, Chang H, Qi Z, Hu B, Malone D, Cogswell J.

PLoS One. 2013;8(1):e54415. doi: 10.1371/journal.pone.0054415.

PMID: 23349881

 

Integrated histopathological and urinary metabonomic investigation of the pathogenesis of microcystin-LR toxicosis.

Cantor GH, Beckonert O, Bollard ME, Keun HC, Ebbels TM, Antti H, Wijsman JA, Bible RH, Breau AP, Cockerell GL, Holmes E, Lindon JC, Nicholson JK.

Vet Pathol. 2013 Jan;50(1):159-71. doi: 10.1177/0300985812443839.

PMID: 22552484

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2012 Publications

Bioactivation of 2-(alkylthio)-1,3,4-thiadiazoles and 2-(alkylthio)-1,3-benzothiazoles.

Yang Y, Qiu F, Josephs JL, Humphreys WG, Shu YZ.

Chem Res Toxicol. 2012 Dec 17;25(12):2770-9. doi: 10.1021/tx3003998.

PMID: 23148672

 

Surfactant choice and the physical stability of nanosuspensions as a function of pH.

Donoso MD, Haskell RJ, Schartman RR.

Int J Pharm. 2012 Dec 15;439(1-2):1-7. doi: 10.1016/j.ijpharm.2012.09.012.

PMID: 22982488

 

Mechanistic basis for the effects of process parameters on quality attributes in high shear wet granulation.

Badawy SI, Narang AS, LaMarche K, Subramanian G, Varia SA.

Int J Pharm. 2012 Dec 15;439(1-2):324-33. doi: 10.1016/j.ijpharm.2012.09.011.

PMID: 22981985

 

Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine.

Luo G, Chen L, Conway CM, Denton R, Keavy D, Signor L, Kostich W, Lentz KA, Santone KS, Schartman R, Browning M, Tong G, Houston JG, Dubowchik GM, Macor JE.

J Med Chem. 2012 Dec 13;55(23):10644-51. doi: 10.1021/jm3013147.

PMID: 23153230

 

Evaluation of the performance characteristics of bilayer tablets: Part I. Impact of material properties and process parameters on the strength of bilayer tablets.

Kottala N, Abebe A, Sprockel O, Bergum J, Nikfar F, Cuitiño AM.

AAPS PharmSciTech. 2012 Dec;13(4):1236-42. doi: 10.1208/s12249-012-9845-9.

PMID: 22976242

 

Evaluation of the performance characteristics of bilayer tablets: Part II. Impact of environmental conditions on the strength of bilayer tablets.

Kottala N, Abebe A, Sprockel O, Bergum J, Nikfar F, Cuitiño AM.

AAPS PharmSciTech. 2012 Dec;13(4):1190-6. doi: 10.1208/s12249-012-9846-8.

PMID: 22965660

 

Simple and efficient digestion of a monoclonal antibody in serum using pellet digestion: comparison with traditional digestion methods in LC-MS/MS bioanalysis.

Yuan L, Arnold ME, Aubry AF, Ji QC.

Bioanalysis. 2012 Dec;4(24):2887-96. doi: 10.4155/bio.12.284.

PMID: 23244280

 

Automated dried blood spots standard and QC sample preparation using a robotic liquid handler.

Yuan L, Zhang D, Aubry AF, Arnold ME.

Bioanalysis. 2012 Dec;4(23):2795-804. doi: 10.4155/bio.12.264.

PMID: 23216120

 

Development of oral extended release formulations of 6-hydroxybuspirone.

Nicholson SJ, Timmins P, Dockens RC, Connor A, Croop R, Ferrie P, Zeng J, Dennis AB, Wilding I.

Biopharm Drug Dispos. 2012 Dec;33(9):522-35. doi: 10.1002/bdd.1819.

PMID: 23065950

 

Effect of saxagliptin on the pharmacokinetics of the active components of Ortho-Cyclen(®), a combined oral contraceptive containing ethinyl estradiol and norgestimate, in healthy women.

Upreti VV, Hsiang CB, Li L, Xu X, LaCreta FP, Boulton DW.

Diabetes Obes Metab. 2012 Dec;14(12):1155-7. doi: 10.1111/j.1463-1326.2012.01635.x.

PMID: 22776778

 

Structural mass spectrometry in biologics discovery: advances and future trends.

Mo J, Tymiak AA, Chen G.

Drug Discov Today. 2012 Dec;17(23-24):1323-30. doi: 10.1016/j.drudis.2012.07.006. Review.

PMID: 22819924

 

Biosimilars and biobetters as tools for understanding and mitigating the immunogenicity of biotherapeutics.

Barbosa MD, Kumar S, Loughrey H, Singh SK.

Drug Discov Today. 2012 Dec;17(23-24):1282-8. doi: 10.1016/j.drudis.2012.07.003. Review.

PMID: 22796124

 

Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology.

Gong J, Gan J, Masson E, Syed S, Xia YQ, Williams D, Pursley J, Jemal M, Humphreys WG, Iyer RA.

Drug Metab Dispos. 2012 Dec;40(12):2374-80. doi: 10.1124/dmd.112.047340.

PMID: 22983304

 

Microbial transformation of 2-amino-4-methyl-3-nitropyridine.

Tully T, Liu M, Huang Y, Ye Q, Patel RN, Goswami A.

J Ind Microbiol Biotechnol. 2012 Dec;39(12):1789-99. doi: 10.1007/s10295-012-1189-7.

PMID: 22926342

 

Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.

Cavallaro CL, Briceno S, Chen J, Cvijic ME, Davies P, Hynes J Jr, Liu RQ, Mandlekar S, Rose AV, Tebben AJ, Van Kirk K, Watson A, Wu H, Yang G, Carter PH.

J Med Chem. 2012 Nov 26;55(22):9643-53. doi: 10.1021/jm300896d.

PMID: 23075267

 

Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.

Jiang H, Zeng J, Li W, Bifano M, Gu H, Titsch C, Easter J, Burrell R, Kandoussi H, Aubry AF, Arnold ME.

Anal Chem. 2012 Nov 20;84(22):10031-7. doi: 10.1021/ac3024558.

PMID: 23106420

 

2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors.

Parker MF, Barten DM, Bergstrom CP, Bronson JJ, Corsa JA, Dee MF, Gai Y, Guss VL, Higgins MA, Keavy DJ, Loo A, Mate RA, Marcin LR, McElhone KE, Polson CT, Roberts SB, Macor JE.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6828-31. doi: 10.1016/j.bmcl.2012.09.057.

PMID: 23046960

 

Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.

Gerritz SW, Zhai W, Shi S, Zhu S, Toyn JH, Meredith JE Jr, Iben LG, Burton CR, Albright CF, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Metzler W, Cook LS, Padmanabha R, Lentz KA, Sofia MJ, Poss MA, Macor JE, Thompson LA 3rd.

J Med Chem. 2012 Nov 8;55(21):9208-23. doi: 10.1021/jm300931y.

PMID: 23030502

 

Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease.

Coric V, van Dyck CH, Salloway S, Andreasen N, Brody M, Richter RW, Soininen H, Thein S, Shiovitz T, Pilcher G, Colby S, Rollin L, Dockens R, Pachai C, Portelius E, Andreasson U, Blennow K, Soares H, Albright C, Feldman HH, Berman RM.

Arch Neurol. 2012 Nov;69(11):1430-40.

PMID: 22892585

 

[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents.

Deskus JA, Dischino DD, Mattson RJ, Ditta JL, Parker MF, Denhart DJ, Zuev D, Huang H, Hartz RA, Ahuja VT, Wong H, Mattson GK, Molski TF, Grace JE Jr, Zueva L, Nielsen JM, Dulac H, Li YW, Guaraldi M, Azure M, Onthank D, Hayes M, Wexler E, McDonald J, Lodge NJ, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6651-5. doi: 10.1016/j.bmcl.2012.08.112.

PMID: 23010264

 

Effects of single doses of avagacestat (BMS-708163) on cerebrospinal fluid Aβ levels in healthy young men.

Tong G, Castaneda L, Wang JS, Sverdlov O, Huang SP, Slemmon R, Gu H, Wong O, Li H, Berman RM, Smith C, Albright C, Dockens RC.

Clin Drug Investig. 2012 Nov;32(11):761-9. doi: 10.1007/s40261-012-0006-4.

PMID: 23018285

 

Characterization and identification of alanine to serine sequence variants in an IgG4 monoclonal antibody produced in mammalian cell lines.

Fu J, Bongers J, Tao L, Huang D, Ludwig R, Huang Y, Qian Y, Basch J, Goldstein J, Krishnan R, You L, Li ZJ, Russell RJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:1-8. doi: 10.1016/j.jchromb.2012.09.023.

PMID: 23122394

 

Incidence of urinary tract infection among patients with type 2 diabetes in the UK General Practice Research Database (GPRD).

Hirji I, Guo Z, Andersson SW, Hammar N, Gomez-Caminero A.

J Diabetes Complications. 2012 Nov-Dec;26(6):513-6. doi: 10.1016/j.jdiacomp.2012.06.008.

PMID: 22889712

 

Incidence of genital infection among patients with type 2 diabetes in the UK General Practice Research Database.

Hirji I, Andersson SW, Guo Z, Hammar N, Gomez-Caminero A.

J Diabetes Complications. 2012 Nov-Dec;26(6):501-5. doi: 10.1016/j.jdiacomp.2012.06.012.

PMID: 22840886

 

Application of a design of experiment approach in the development of a sensitive bioanalytical assay in human plasma.

Dawes ML, Bergum JS, Schuster AE, Aubry AF.

J Pharm Biomed Anal. 2012 Nov;70:401-7. doi: 10.1016/j.jpba.2012.06.011.

PMID: 22776736

 

A validated enantioselective LC-MS/MS assay for the simultaneous determination of carvedilol and its pharmacologically active 4'-hydroxyphenyl metabolite in human plasma: application to a clinical pharmacokinetic study.

Furlong MT, He B, Mylott W, Zhao S, Mariannino T, Shen J, Stouffer B.

J Pharm Biomed Anal. 2012 Nov;70:574-9. doi: 10.1016/j.jpba.2012.05.026.

PMID: 22709607

 

Evaluation of mobile phase gradient supercritical fluid chromatography for impurity profiling of pharmaceutical compounds.

Alexander AJ, Hooker TF, Tomasella FP.

J Pharm Biomed Anal. 2012 Nov;70:77-86. doi: 10.1016/j.jpba.2012.05.025.

PMID: 22687460

 

Impact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats.

Vuppugalla R, Zhang Y, Chang S, Rodrigues AD, Marathe PH.

Xenobiotica. 2012 Nov;42(11):1058-68. doi: 10.3109/00498254.2012.684104.

PMID: 22574883

 

Addressing drug effects on cut point determination for an anti-drug antibody assay.

Barbosa MD, Gleason CR, Phillips KR, Berisha F, Stouffer B, Warrack BM, Chen G.

J Immunol Methods. 2012 Oct 31;384(1-2):152-6. doi: 10.1016/j.jim.2012.06.014.

PMID: 22750627

 

Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors.

Miller MM, Liu Y, Jiang J, Johnson JA, Kamau M, Nirschl DS, Wang Y, Harikrishnan L, Taylor DS, Chen AY, Yin X, Seethala R, Peterson TL, Zvyaga T, Zhang J, Huang CS, Wexler RR, Poss MA, Lawrence RM, Adam LP, Salvati ME.

Bioorg Med Chem Lett. 2012 Oct 15;22(20):6503-8. doi: 10.1016/j.bmcl.2012.08.011.

PMID: 22995620

 

Influence of compaction properties and interfacial topography on the performance of bilayer tablets.

Kottala N, Abebe A, Sprockel O, Akseli I, Nikfar F, Cuitiño AM.

Int J Pharm. 2012 Oct 15;436(1-2):171-8. doi: 10.1016/j.ijpharm.2012.05.026.

PMID: 22728259

 

Roller compaction process development and scale up using Johanson model calibrated with instrumented roll data.

Nesarikar VV, Patel C, Early W, Vatsaraj N, Sprockel O, Jerzweski R.

Int J Pharm. 2012 Oct 15;436(1-2):486-507. doi: 10.1016/j.ijpharm.2012.06.027.

PMID: 22721851

 

Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032).

McPhee F, Sheaffer AK, Friborg J, Hernandez D, Falk P, Zhai G, Levine S, Chaniewski S, Yu F, Barry D, Chen C, Lee MS, Mosure K, Sun LQ, Sinz M, Meanwell NA, Colonno RJ, Knipe J, Scola P.

Antimicrob Agents Chemother. 2012 Oct;56(10):5387-96. doi: 10.1128/AAC.01186-12.

PMID: 22869577

 

Effect on hepatitis C virus replication of combinations of direct-acting antivirals, including NS5A inhibitor daclatasvir.

Pelosi LA, Voss S, Liu M, Gao M, Lemm JA.

Antimicrob Agents Chemother. 2012 Oct;56(10):5230-9. doi: 10.1128/AAC.01209-12.

PMID: 22850513

 

Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease.

Soares HD, Potter WZ, Pickering E, Kuhn M, Immermann FW, Shera DM, Ferm M, Dean RA, Simon AJ, Swenson F, Siuciak JA, Kaplow J, Thambisetty M, Zagouras P, Koroshetz WJ, Wan HI, Trojanowski JQ, Shaw LM; Biomarkers Consortium Alzheimer's Disease Plasma Proteomics Project..

Arch Neurol. 2012 Oct;69(10):1310-7.

PMID: 22801723

 

HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.

St Laurent DR, Belema M, Gao M, Goodrich J, Kakarla R, Knipe JO, Lemm JA, Liu M, Lopez OD, Nguyen VN, Nower PT, O'Boyle D 2nd, Qiu Y, Romine JL, Serrano-Wu MH, Sun JH, Valera L, Yang F, Yang X, Meanwell NA, Snyder LB.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6063-6. doi: 10.1016/j.bmcl.2012.08.049.

PMID: 22959243

 

Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Mo R, Meyer DT, Pechulis AD, Guaciaro MA, Lo YC, Yang G, Miller PB, Scherle PA, Zhao Q, Cvijic ME, Barrish JC, Decicco CP, Carter PH.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6181-4. doi: 10.1016/j.bmcl.2012.08.002.

PMID: 22939233

 

The cloning of the gene for hereditary hemochromatosis.

Feder JN, Thomas W.

Clin Chem. 2012 Oct;58(10):1485-6. No abstract available.

PMID: 22691273

 

A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects.

Dockens R, Wang JS, Castaneda L, Sverdlov O, Huang SP, Slemmon R, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Tong G.

Clin Pharmacokinet. 2012 Oct 1;51(10):681-93.

PMID: 23018531

 

Lack of a pharmacokinetic drug-drug interaction between lithium and valproate when co-administered with aripiprazole.

Boulton DW, Kollia GD, Mallikaarjun S, Kornhauser DM.

J Clin Pharm Ther. 2012 Oct;37(5):565-70. doi: 10.1111/j.1365-2710.2012.01331.x.

PMID: 22943745

 

Pharmacodynamics, safety, and pharmacokinetics of BMS-663068, an oral HIV-1 attachment inhibitor in HIV-1-infected subjects.

Nettles RE, Schürmann D, Zhu L, Stonier M, Huang SP, Chang I, Chien C, Krystal M, Wind-Rotolo M, Ray N, Hanna GJ, Bertz R, Grasela D.

J Infect Dis. 2012 Oct 1;206(7):1002-11. doi: 10.1093/infdis/jis432.

PMID: 22896665

 

Natural history of chronic hepatitis B: what exactly has REVEAL revealed?

Iloeje UH, Yang HI, Chen CJ.

Liver Int. 2012 Oct;32(9):1333-41. doi: 10.1111/j.1478-3231.2012.02805.x. Review.

PMID: 22510145

 

Impact of excipient interactions on solid dosage form stability.

Narang AS, Desai D, Badawy S.

Pharm Res. 2012 Oct;29(10):2660-83. doi: 10.1007/s11095-012-0782-9. Review.

PMID: 22707362

 

Solution behavior of PVP-VA and HPMC-AS-based amorphous solid dispersions and their bioavailability implications.

Qian F, Wang J, Hartley R, Tao J, Haddadin R, Mathias N, Hussain M.

Pharm Res. 2012 Oct;29(10):2765-76.

PMID: 22315020

 

Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs.

Tomlinson L, Tirmenstein MA, Janovitz EB, Aranibar N, Ott KH, Kozlosky JC, Patrone LM, Achanzar WE, Augustine KA, Brannen KC, Carlson KE, Charlap JH, Dubrow KM, Kang L, Rosini LT, Panzica-Kelly JM, Flint OP, Moulin FJ, Megill JR, Zhang H, Bennett MJ, Horvath JJ.

Toxicol Sci. 2012 Oct;129(2):268-79. doi: 10.1093/toxsci/kfs217.

PMID: 22821849

 

Application of lipid-based formulations in drug discovery.

Chen XQ, Gudmundsson OS, Hageman MJ.

J Med Chem. 2012 Sep 27;55(18):7945-56. Review. No abstract available.

PMID: 22779739

 

Efficient and scalable enantioselective synthesis of a CGRP antagonist.

Leahy DK, Fan Y, Desai LV, Chan C, Zhu J, Luo G, Chen L, Hanson RL, Sugiyama M, Rosner T, Cuniere N, Guo Z, Hsiao Y, Gao Q.

Org Lett. 2012 Sep 21;14(18):4938-41.

PMID: 22954228

 

Modulation of cofilin phosphorylation by inhibition of the Lim family kinases.

He L, Seitz SP, Trainor GL, Tortolani D, Vaccaro W, Poss M, Tarby CM, Tokarski JS, Penhallow B, Hung CY, Attar R, Lin TA.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. doi: 10.1016/j.bmcl.2012.07.002.

PMID: 22902653

 

Utility of in situ sodium alginate/karaya gum gels to facilitate gastric retention in rodents.

Foster KA, Morgen M, Murri B, Yates I, Fancher RM, Ehrmann J, Gudmundsson OS, Hageman MJ.

Int J Pharm. 2012 Sep 15;434(1-2):406-12. doi: 10.1016/j.ijpharm.2012.06.009.

PMID: 22692076

 

Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification.

Weller HN, Nirschl DS, Paulson JL, Hoffman SL, Bullock WH.

ACS Comb Sci. 2012 Sep 10;14(9):520-6. doi: 10.1021/co300075g.

PMID: 22909004

 

The use of modeling tools to drive efficient oral product design.

Mathias NR, Crison J.

AAPS J. 2012 Sep;14(3):591-600. doi: 10.1208/s12248-012-9372-3. Review.

PMID: 22644702

 

Medical care costs and hospitalization in patients with bipolar disorder treated with atypical antipsychotics.

Bergeson JG, Kalsekar I, Jing Y, You M, Forbes RA, Hebden T.

Am Health Drug Benefits. 2012 Sep;5(6):379-86.

PMID: 24991334

 

Evolution of end points for cancer immunotherapy trials.

Hoos A.

Ann Oncol. 2012 Sep;23 Suppl 8:viii47-52. doi: 10.1093/annonc/mds263.

PMID: 22918928

 

2012 white paper on recent issues in bioanalysis and alignment of multiple guidelines.

DeSilva B, Garofolo F, Rocci M, Martinez S, Dumont I, Landry F, Dicaire C, Szekely-Klepser G, Weiner R, Arnold M, Bansal S, Bateman K, Bauer R, Booth B, Davis S, Dudal S, Gouty D, Grundy J, Haidar S, Hayes R, Jemal M, Kaur S, Kelley M, Knutsson M, Le Blaye O, Lee J, Lowes S, Ma M, Mitsuoka T, Neto JT, Nicholson R, Ormsby E, Sailstad J, Stevenson L, Tang D, Welink J, Viswanathan CT, Wang L, Woolf E, Yang E.

Bioanalysis. 2012 Sep;4(18):2213-26. doi: 10.4155/bio.12.205.

PMID: 23046264

 

Enoxaparin dosing after discharge from US hospitals in patients with total knee replacement.

Wright R, Kawabata H, Pan X, Simon TA, Ramacciotti E.

Clin Appl Thromb Hemost. 2012 Sep;18(5):514-8. doi: 10.1177/1076029611433643.

PMID: 22345487

 

Evaluation of six proton pump inhibitors as inhibitors of various human cytochromes P450: focus on cytochrome P450 2C19.

Zvyaga T, Chang SY, Chen C, Yang Z, Vuppugalla R, Hurley J, Thorndike D, Wagner A, Chimalakonda A, Rodrigues AD.

Drug Metab Dispos. 2012 Sep;40(9):1698-711. doi: 10.1124/dmd.112.045575.

PMID: 22648560

 

Development of a carbon-14 labeling approach to support disposition studies with a pegylated biologic.

Wang H, Wang L, Cao K, Emanuel SL, Morin P, Lin Z, Shen G, Hosbach J, Zhang D, Bonacorsi S, Rodrigues AD, Yang Z.

Drug Metab Dispos. 2012 Sep;40(9):1677-85. doi: 10.1124/dmd.112.044792.

PMID: 22627466

 

A novel ring oxidation of 4- or 5-substituted 2H-oxazole to corresponding 2-oxazolone catalyzed by cytosolic aldehyde oxidase.

Arora VK, Philip T, Huang S, Shu YZ.

Drug Metab Dispos. 2012 Sep;40(9):1668-76. doi: 10.1124/dmd.112.044545.

PMID: 22621803

 

ABRF-MIRG benchmark study: molecular interactions in a three-component system.

Yamniuk AP, Edavettal SC, Bergqvist S, Yadav SP, Doyle ML, Calabrese K, Parsons JF, Eisenstein E.

J Biomol Tech. 2012 Sep;23(3):101-14. doi: 10.7171/jbt.12-2303-003.

PMID: 22942790

 

A Bayesian approach for inference from a bridging study with binary outcomes.

Gandhi M, Mukherjee B, Biswas D.

J Biopharm Stat. 2012 Sep;22(5):935-51. doi: 10.1080/10543406.2012.698436. Review.

PMID: 22946941

 

Food increased the bioavailability of BMS-690514, an orally active EGFR/HER2/VEGF receptor kinase inhibitor, in healthy subjects.

Vakkalagadda B, Park JS, Ahlers CM, Dorizio S, Has T, Roongta V, Heller KN, Derbin GM, Zhang S.

J Clin Pharmacol. 2012 Sep;52(9):1350-6. doi: 10.1177/0091270011417826.

PMID: 22031621

 

Formation of reactive impurities in aqueous and neat polyethylene glycol 400 and effects of antioxidants and oxidation inducers.

Hemenway JN, Carvalho TC, Rao VM, Wu Y, Levons JK, Narang AS, Paruchuri SR, Stamato HJ, Varia SA.

J Pharm Sci. 2012 Sep;101(9):3305-18. doi: 10.1002/jps.23198.

PMID: 22610374

 

Degradation kinetics and mechanism of an oxadiazole derivative, design of a stable drug product for BMS-708163, a γ-secretase inhibitor drug candidate.

Hartley RF, Huang Y, Cassidy M, Razler TM, Qian F, Hussain MA.

J Pharm Sci. 2012 Sep;101(9):3124-33. doi: 10.1002/jps.23050.

PMID: 22262489

 

Acid-catalyzed hydrolysis of BMS-582664: degradation product identification and mechanism elucidation.

Zhao F, Derbin G, Miller S, Badawy S, Hussain M.

J Pharm Sci. 2012 Sep;101(9):3526-30. doi: 10.1002/jps.23028.

PMID: 22189636

 

Predicting feasibility and characterizing performance of extended-release formulations using physiologically based pharmacokinetic modeling.

Brown J, Crison J, Timmins P.

Ther Deliv. 2012 Sep;3(9):1047-59. Review.

PMID: 23035591

 

Comparison of 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide Based Strategies to Crosslink Antibodies on Amine-Functionalized Platforms for Immunodiagnostic Applications.

Vashist SK.

Diagnostics (Basel). 2012 Aug 27;2(3):23-33. doi: 10.3390/diagnostics2030023.

PMID: 26859395

 

Development of a precipitation-resistant solution formulation to increase in vivo exposure of a poorly water-soluble compound.

Burton L, Ying W, Gandhi R, West R, Huang C, Zhou S, Shah K, Chen J, Shen X.

Int J Pharm. 2012 Aug 20;433(1-2):94-101. doi: 10.1016/j.ijpharm.2012.04.075.

PMID: 22569200

 

Internal multiple-scattering hole-enhanced Raman spectroscopy: improved backscattering Fourier transform Raman sampling in pharmaceutical tablets utilizing cylindrical-conical holes.

Larkin PJ, Santangelo M, Šašiċ S.

Appl Spectrosc. 2012 Aug;66(8):892-902. doi: 10.1366/12-06677.

PMID: 22800376

 

What is next for dried blood spots?

Ji QC, Liu G, D'Arienzo CJ, Olah TV, Arnold ME.

Bioanalysis. 2012 Aug;4(16):2059-65. doi: 10.4155/bio.12.168.

PMID: 22946921

 

Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.

Wei C, Grace JE Jr, Zvyaga TA, Drexler DM.

Bioanalysis. 2012 Aug;4(15):1895-905. doi: 10.4155/bio.12.151.

PMID: 22943620

 

Overcoming bioanalytical challenges in an Onglyza(®) intravenous [(14)C]microdose absolute bioavailability study with accelerator MS.

Xu XS, Dueker SR, Christopher LJ, Lohstroh PN, Keung CF, Cao KK, Bonacorsi SJ, Cojocaru L, Shen JX, Humphreys WG, Stouffer B, Arnold ME.

Bioanalysis. 2012 Aug;4(15):1855-70. doi: 10.4155/bio.12.171.

PMID: 22943617

 

A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies.

Furlong MT, Ouyang Z, Wu S, Tamura J, Olah T, Tymiak A, Jemal M.

Biomed Chromatogr. 2012 Aug;26(8):1024-32. doi: 10.1002/bmc.2759.

PMID: 22623136

 

Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists.

Dzierba CD, Sielecki TM, Arvanitis AG, Galka A, Johnson TL, Takvorian AG, Rafalski M, Kasireddy-Polam P, Vig S, Dasgupta B, Zhang G, Molski TF, Wong H, Zaczek RC, Lodge NJ, Combs AP, Gilligan PJ, Trainor GL, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):4986-9. doi: 10.1016/j.bmcl.2012.06.034.

PMID: 22749422

 

Time-varying belatacept exposure and its relationship to efficacy/safety responses in kidney-transplant recipients.

Zhou Z, Shen J, Hong Y, Kaul S, Pfister M, Roy A.

Clin Pharmacol Ther. 2012 Aug;92(2):251-7. doi: 10.1038/clpt.2012.84.

PMID: 22760001

 

Assessing cell fusion and cytokinesis failure as mechanisms of clone 9 hepatocyte multinucleation in vitro.

Simic D, Euler C, Thurby C, Peden M, Tannehill-Gregg S, Bunch T, Sanderson T, Van Vleet T.

Curr Protoc Toxicol. 2012 Aug;Chapter 14:Unit 14.9.1-17. doi: 10.1002/0471140856.tx1409s53.

PMID: 22896007

 

The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.

Soars MG, Barton P, Ismair M, Jupp R, Riley RJ.

Drug Metab Dispos. 2012 Aug;40(8):1641-8. doi: 10.1124/dmd.111.042382.

PMID: 22587986

 

Reduction of N-terminal methionylation while increasing titer by lowering metabolic and protein production rates in E. coli auto-induced fed-batch fermentation.

Xu J, Qian Y, Skonezny PM, You L, Xing Z, Meyers DS, Stankavage RJ, Pan SH, Li ZJ.

J Ind Microbiol Biotechnol. 2012 Aug;39(8):1199-208. doi: 10.1007/s10295-012-1127-8.

PMID: 22526331

 

GPCR assay automation for leveraging lead optimization.

Cvijic ME, Chen J, Kubala S, Nolfo J, Kolodin G, Zhang L.

J Lab Autom. 2012 Aug;17(4):266-74. doi: 10.1177/2211068212442502.

PMID: 22505604

 

Approach to improve compound recovery in a high-throughput Caco-2 permeability assay supported by liquid chromatography-tandem mass spectrometry.

Cai X, Walker A, Cheng C, Paiva A, Li Y, Kolb J, Herbst J, Shou W, Weller H.

J Pharm Sci. 2012 Aug;101(8):2755-62. doi: 10.1002/jps.23194.

PMID: 22611052

 

A platelet target for venous thrombosis? P2Y1 deletion or antagonism protects mice from vena cava thrombosis.

Bird JE, Wang X, Smith PL, Barbera F, Huang C, Schumacher WA.

J Thromb Thrombolysis. 2012 Aug;34(2):199-207. doi: 10.1007/s11239-012-0745-3.

PMID: 22588534

 

Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats.

Devenny JJ, Godonis HE, Harvey SJ, Rooney S, Cullen MJ, Pelleymounter MA.

Obesity (Silver Spring). 2012 Aug;20(8):1645-52. doi: 10.1038/oby.2012.59.

PMID: 22402735

 

Influenza nucleoprotein: promising target for antiviral chemotherapy.

Cianci C, Gerritz SW, Deminie C, Krystal M.

Antivir Chem Chemother. 2012 Jul 26;23(3):77-91. doi: 10.3851/IMP2235. Review.

PMID: 22837443

 

The efficacy and safety of the dipeptidyl peptidase-4 inhibitor saxagliptin in treatment-naïve patients with type 2 diabetes mellitus: a randomized controlled trial.

Frederich R, McNeill R, Berglind N, Fleming D, Chen R.

Diabetol Metab Syndr. 2012 Jul 24;4(1):36. doi: 10.1186/1758-5996-4-36.

PMID: 22828124

 

Synthetic approaches to a chiral 4-amino-3-hydroxy piperidine with pharmaceutical relevance.

Ortiz A, Young IS, Sawyer JR, Hsiao Y, Singh A, Sugiyama M, Corbett RM, Chau M, Shi Z, Conlon DA.

Org Biomol Chem. 2012 Jul 21;10(27):5253-7. doi: 10.1039/c2ob25411e.

PMID: 22648308

 

Comparison of health-related quality of life among patients using atypical antipsychotics for treatment of depression: results from the National Health and Wellness Survey.

Kalsekar I, Wagner JS, DiBonaventura M, Bates J, Forbes R, Hebden T.

Health Qual Life Outcomes. 2012 Jul 17;10:81. doi: 10.1186/1477-7525-10-81.

PMID: 22805425

 

Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor.

Chaturvedula PV, Pin S, Tholady G, Conway CM, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4719-22. doi: 10.1016/j.bmcl.2012.05.118.

PMID: 22732695

 

The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1.

Han X, Civiello RL, Conway CM, Cook DA, Davis CD, Macci R, Pin SS, Ren SX, Schartman R, Signor LJ, Thalody G, Widmann KA, Xu C, Chaturvedula PV, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4723-7. doi: 10.1016/j.bmcl.2012.05.074.

PMID: 22727645

 

Separation and detection of bis-maleimide-polyethylene glycol and mono-maleimide-polyethylene glycol by reversed-phase high pressure liquid chromatography.

Tang L, Jariwala F, Bolgar M, Lloyd DK.

2012 Jul 13;1246:117-22. doi: 10.1016/j.chroma.2012.03.044.

PMID: 22503616

 

Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.

Harikrishnan LS, Finlay HJ, Qiao JX, Kamau MG, Jiang J, Wang TC, Li J, Cooper CB, Poss MA, Adam LP, Taylor DS, Chen AY, Yin X, Sleph PG, Yang RZ, Sitkoff DF, Galella MA, Nirschl DS, Van Kirk K, Miller AV, Huang CS, Chang M, Chen XQ, Salvati ME, Wexler RR, Lawrence RM.

J Med Chem. 2012 Jul 12;55(13):6162-75. doi: 10.1021/jm300611v.

PMID: 22650305

 

A sensitive and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of the novel hepatitis C NS5A inhibitor BMS-790052 (daclastasvir) in human plasma and urine.

Jiang H, Zeng J, Kandoussi H, Liu Y, Wang X, Bifano M, Cojocaru L, Ryan J, Arnold ME.

J Chromatogr A. 2012 Jul 6;1245:117-21. doi: 10.1016/j.chroma.2012.05.028.

PMID: 22640838

 

In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068.

Nowicka-Sans B, Gong YF, McAuliffe B, Dicker I, Ho HT, Zhou N, Eggers B, Lin PF, Ray N, Wind-Rotolo M, Zhu L, Majumdar A, Stock D, Lataillade M, Hanna GJ, Matiskella JD, Ueda Y, Wang T, Kadow JF, Meanwell NA, Krystal M.

Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507. doi: 10.1128/AAC.00426-12.

PMID: 22547625

 

Resistance analysis of the hepatitis C virus NS3 protease inhibitor asunaprevir.

McPhee F, Friborg J, Levine S, Chen C, Falk P, Yu F, Hernandez D, Lee MS, Chaniewski S, Sheaffer AK, Pasquinelli C.

Antimicrob Agents Chemother. 2012 Jul;56(7):3670-81. doi: 10.1128/AAC.00308-12.

PMID: 22508297

 

A semi-automated method for the integrated evaluation of half-life and metabolic soft spots of discovery compounds.

Grubb MF, Humphreys WG, Josephs JL.

Bioanalysis. 2012 Jul;4(14):1747-61. doi: 10.4155/BIO.12.134.

PMID: 22877221

 

An immune-active tumor microenvironment favors clinical response to ipilimumab.

Ji RR, Chasalow SD, Wang L, Hamid O, Schmidt H, Cogswell J, Alaparthy S, Berman D, Jure-Kunkel M, Siemers NO, Jackson JR, Shahabi V.

Cancer Immunol Immunother. 2012 Jul;61(7):1019-31. doi: 10.1007/s00262-011-1172-6.

PMID: 22146893

 

Case study: technology initiative led to advanced lead optimization screening processes at Bristol-Myers Squibb, 2004-2009.

Zhang L, Cvijic ME, Lippy J, Myslik J, Brenner SL, Binnie A, Houston JG.

Drug Discov Today. 2012 Jul;17(13-14):733-40. doi: 10.1016/j.drudis.2012.02.012. Review.

PMID: 22425710

 

Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human.

Su H, Boulton DW, Barros A Jr, Wang L, Cao K, Bonacorsi SJ Jr, Iyer RA, Humphreys WG, Christopher LJ.

Drug Metab Dispos. 2012 Jul;40(7):1345-56. doi: 10.1124/dmd.112.045450.

PMID: 22496391

 

Comparison of the peak-to-trough fluctuation in plasma concentration of long-acting injectable antipsychotics and their oral equivalents.

Sheehan JJ, Reilly KR, Fu DJ, Alphs L.

Innov Clin Neurosci. 2012 Jul;9(7-8):17-23.

PMID: 22984648

 

Preclinical safety, pharmacokinetics, and pharmacodynamics of recombinant human interleukin-21 in cynomolgus macaques (Macaca fascicularis).

Waggie KS, Holdren MS, Byrnes-Blake K, Pedersen S, Ponce R, Hughes S, Miller DM.

Int J Toxicol. 2012 Jul-Aug;31(4):303-16. doi: 10.1177/1091581812449661.

PMID: 22723515

 

Mitigation of signal suppression caused by the use of trifluoroacetic acid in liquid chromatography mobile phases during liquid chromatography/mass spectrometry analysis via post-column addition of ammonium hydroxide.

Chan CC, Bolgar MS, Dalpathado D, Lloyd DK.

Rapid Commun Mass Spectrom. 2012 Jun 30;26(12):1507-14. doi: 10.1002/rcm.6240.

PMID: 22592995

 

Systematic evaluation of the root cause of non-linearity in liquid chromatography/tandem mass spectrometry bioanalytical assays and strategy to predict and extend the linear standard curve range.

Yuan L, Zhang D, Jemal M, Aubry AF.

Rapid Commun Mass Spectrom. 2012 Jun 30;26(12):1465-74. doi: 10.1002/rcm.6252.

PMID: 22592990

 

Expression Profile of Drug and Nutrient Absorption Related Genes in Madin-Darby Canine Kidney (MDCK) Cells Grown under Differentiation Conditions.

Quan Y, Jin Y, Faria TN, Tilford CA, He A, Wall DA, Smith RL, Vig BS.

Pharmaceutics. 2012 Jun 18;4(2):314-33. doi: 10.3390/pharmaceutics4020314.

PMID: 24300234

 

Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists.

Perez HL, Banfi P, Bertrand J, Cai ZW, Grebinski JW, Kim K, Lippy J, Modugno M, Naglich J, Schmidt RJ, Tebben A, Vianello P, Wei DD, Zhang L, Galvani A, Lombardo LJ, Borzilleri RM.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):3946-50. doi: 10.1016/j.bmcl.2012.04.103.

PMID: 22608961

 

Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.

Schroeder GM, Wei D, Banfi P, Cai ZW, Lippy J, Menichincheri M, Modugno M, Naglich J, Penhallow B, Perez HL, Sack J, Schmidt RJ, Tebben A, Yan C, Zhang L, Galvani A, Lombardo LJ, Borzilleri RM.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):3951-6. doi: 10.1016/j.bmcl.2012.04.106.

PMID: 22608393

 

Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry.

Zheng N, Fung EN, Buzescu A, Arnold ME, Zeng J.

Rapid Commun Mass Spectrom. 2012 Jun 15;26(11):1291-304. doi: 10.1002/rcm.6230.

PMID: 22555922

 

Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies.

Gu H, Wang J, Aubry AF, Jiang H, Zeng J, Easter J, Wang JS, Dockens R, Bifano M, Burrell R, Arnold ME.

Anal Chem. 2012 Jun 5;84(11):4844-50. doi: 10.1021/ac300442v.

PMID: 22540405

 

Validation and life-cycle management of a quantitative ligand-binding assay for the measurement of Nulojix(®), a CTLA-4-Fc fusion protein, in renal and liver transplant patients.

Myler HA, Phillips KR, Dong H, Tabler E, Shaikh M, Coats V, Hay L, Tacey R, Stouffer B.

Bioanalysis. 2012 Jun;4(10):1215-26. doi: 10.4155/bio.12.79.

PMID: 22651565

 

Conference report: bioanalytical sessions at the 2011 Eastern Analytical Symposium.

Dawes M, Zhao Y, Aubry AF.

Bioanalysis. 2012 Jun;4(10):1151-3. doi: 10.4155/bio.12.103.

PMID: 22651557

 

Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight.

Rohrbach K, Thomas MA, Glick S, Fung EN, Wang V, Watson L, Gregory P, Antel J, Pelleymounter MA.

Diabetes Obes Metab. 2012 Jun;14(6):555-64. doi: 10.1111/j.1463-1326.2012.01563.x.

PMID: 22268426

 

In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist.

Zhou L, Dockens RC, Liu-Kreyche P, Grossman SJ, Iyer RA.

Drug Metab Dispos. 2012 Jun;40(6):1093-103. doi: 10.1124/dmd.111.043596.

PMID: 22381334

 

A simplified protocol employing elacridar in rodents: a screening model in drug discovery to assess P-gp mediated efflux at the blood brain barrier.

Kallem R, Kulkarni CP, Patel D, Thakur M, Sinz M, Singh SP, Mahammad SS, Mandlekar S.

Drug Metab Lett. 2012 Jun 1;6(2):134-44.

PMID: 23061481

 

The emergence of factor Xa inhibitors for the treatment of cardiovascular diseases: a patent review.

Pinto DJ, Qiao JX, Knabb RM.

Expert Opin Ther Pat. 2012 Jun;22(6):645-61. doi: 10.1517/13543776.2012.680438. Review.

PMID: 22655676

 

Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5A replication complex inhibitor, BMS-790052.

Sun JH, O'Boyle Ii DR, Zhang Y, Wang C, Nower P, Valera L, Roberts S, Nettles RE, Fridell RA, Gao M.

Hepatology. 2012 Jun;55(6):1692-9. doi: 10.1002/hep.25581.

PMID: 22234905

 

Lack of effect of brivanib on the pharmacokinetics of midazolam, a CYP3A4 substrate, administered intravenously and orally in healthy participants.

Syed S, Clemens PL, Lathers D, Kollia G, Dhar A, Walters I, Masson E.

J Clin Pharmacol. 2012 Jun;52(6):914-21. doi: 10.1177/0091270011407495.

PMID: 21659627

 

A user-friendly robotic sample preparation program for fully automated biological sample pipetting and dilution to benefit the regulated bioanalysis.

Jiang H, Ouyang Z, Zeng J, Yuan L, Zheng N, Jemal M, Arnold ME.

J Lab Autom. 2012 Jun;17(3):211-21. doi: 10.1177/2211068211429775.

PMID: 22357562

 

Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial.

Easton JD, Lopes RD, Bahit MC, Wojdyla DM, Granger CB, Wallentin L, Alings M, Goto S, Lewis BS, Rosenqvist M, Hanna M, Mohan P, Alexander JH, Diener HC; ARISTOTLE Committees and Investigators..

Lancet Neurol. 2012 Jun;11(6):503-11. doi: 10.1016/S1474-4422(12)70092-3. Erratum in: Lancet Neurol. 2012 Dec;11(12):1021.

PMID: 22572202

 

Mechanistic understanding of protein-silicone oil interactions.

Li J, Pinnamaneni S, Quan Y, Jaiswal A, Andersson FI, Zhang X.

Pharm Res. 2012 Jun;29(6):1689-97. doi: 10.1007/s11095-012-0696-6.

PMID: 22350802

 

Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait.

Bird JE, Smith PL, Wang X, Schumacher WA, Barbera F, Revelli JP, Seiffert D.

Thromb Haemost. 2012 Jun;107(6):1141-50. doi: 10.1160/TH-11-10-0682.

PMID: 22398951

 

Regulatory forum opinion piece: blind reading of histopathology slides in general toxicology studies.

Neef N, Nikula KJ, Francke-Carroll S, Boone L.

Toxicol Pathol. 2012 Jun;40(4):697-9. doi: 10.1177/0192623312438737.

PMID: 22407309

 

Development of a streamlined rat whole embryo culture assay for classifying teratogenic potential of pharmaceutical compounds.

Zhang C, Cao J, Kenyon JR, Panzica-Kelly JM, Gong L, Augustine-Rauch K.

Toxicol Sci. 2012 Jun;127(2):535-46. doi: 10.1093/toxsci/kfs112.

PMID: 22430072

 

Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.

Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, Cadelina GW, Decarr LB, Yang L, Liu V, Fessler C, Protassio J, Riff T, Turner H, Janus CG, Sankaranarayanan S, Polson C, Meredith JE, Gray G, Hanna A, Olson RE, Kim SH, Vite GD, Lee FY, Albright CF.

J Neurosci. 2012 May 23;32(21):7137-45. doi: 10.1523/JNEUROSCI.0188-12.2012.

PMID: 22623658

 

An evaluation of process parameters to improve coating efficiency of an active tablet film-coating process.

Wang J, Hemenway J, Chen W, Desai D, Early W, Paruchuri S, Chang SY, Stamato H, Varia S.

Int J Pharm. 2012 May 10;427(2):163-9. doi: 10.1016/j.ijpharm.2012.01.033.

PMID: 22301427

 

Recent development in software and automation tools for high-throughput discovery bioanalysis.

Shou WZ, Zhang J.

Bioanalysis. 2012 May;4(9):1097-109. doi: 10.4155/bio.12.51. Review.

PMID: 22612689

 

A bioanalytical strategy utilizing dried blood spot sampling and LC-MS/MS in discovery toxicology studies.

Discenza L, Obermeier MT, Westhouse R, Olah TV, D'Arienzo CJ.

Bioanalysis. 2012 May;4(9):1057-64. doi: 10.4155/bio.12.69.

PMID: 22612686

 

Discovery bioanalysis. Foreward.

Shou WZ.

Bioanalysis. 2012 May;4(9):983-4. doi: 10.4155/bio.12.102. No abstract available.

PMID: 22612675

 

Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone.

Carter PH, Brown GD, King SR, Voss ME, Tebben AJ, Cherney RJ, Mandlekar S, Lo YC, Yang G, Miller PB, Scherle PA, Zhao Q, Decicco CP.

Bioorg Med Chem Lett. 2012 May 1;22(9):3311-6. doi: 10.1016/j.bmcl.2012.03.007.

PMID: 22475558

 

Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab.

Shahabi V, Whitney G, Hamid O, Schmidt H, Chasalow SD, Alaparthy S, Jackson JR.

Cancer Immunol Immunother. 2012 May;61(5):733-7. doi: 10.1007/s00262-012-1227-3.

PMID: 22382362

 

Sodium glucose co-transporter 2 (SGLT2) inhibitors: novel antidiabetic agents.

Washburn WN.

Expert Opin Ther Pat. 2012 May;22(5):483-94. doi: 10.1517/13543776.2012.680437. Review.

PMID: 22583331

 

Biowaiver approach for biopharmaceutics classification system class 3 compound metformin hydrochloride using in silico modeling.

Crison JR, Timmins P, Keung A, Upreti VV, Boulton DW, Scheer BJ.

J Pharm Sci. 2012 May;101(5):1773-82. doi: 10.1002/jps.23063.

PMID: 22334460

 

Effect of physical states of binders on high-shear wet granulation and granule properties: a mechanistic approach toward understanding high-shear wet granulation process, part 3: effect of binder rheological properties.

Li J, Tao L, Buckley D, Tao J, Gao J, Hubert M.

J Pharm Sci. 2012 May;101(5):1877-87. doi: 10.1002/jps.23059.

PMID: 22271364

 

Investigation of freeze/thaw-related quality attributes of a liquid biopharmaceutical formulation: the role of saccharide excipients.

Zhou R, Schlam RF, Yin S, Gandhi RB, Adams ML.

PDA J Pharm Sci Technol. 2012 May-Jun;66(3):221-35. doi: 10.5731/pdajpst.2012.00861.

PMID: 22634588

 

Galactose can be an inducer for production of therapeutic proteins by auto-induction using E. coli BL21 strains.

Xu J, Banerjee A, Pan SH, Li ZJ.

Protein Expr Purif. 2012 May;83(1):30-6. doi: 10.1016/j.pep.2012.02.014.

PMID: 22425658

 

Glycine to glutamic acid misincorporation observed in a recombinant protein expressed by Escherichia coli cells.

Huang Y, O'Mara B, Conover M, Ludwig R, Fu J, Tao L, Li ZJ, Rieble S, Grace MJ, Russell RJ.

Protein Sci. 2012 May;21(5):625-32. doi: 10.1002/pro.2046.

PMID: 22362707

 

Cost-effectiveness and budget impact of saxagliptine as additional therapy to metformin for the treatment of diabetes mellitus type 2 in the Brazilian private health system.

Nita ME, Eliaschewitz FG, Ribeiro E, Asano E, Barbosa E, Takemoto M, Donato B, Rached R, Rahal E.

Rev Assoc Med Bras (1992). 2012 May-Jun;58(3):294-301. English, Portuguese.

PMID: 22735220

 

A randomised assessment of the pharmacokinetic, pharmacodynamic and safety interaction between apixaban and enoxaparin in healthy subjects.

Barrett YC, Wang J, Song Y, Pursley J, Wastall P, Wright R, Lacreta F, Frost C.

Thromb Haemost. 2012 May;107(5):916-24. doi: 10.1160/TH11-09-0634.

PMID: 22398784

 

Chronic administration of belatacept, a T-cell costimulatory signal blocker, in cynomolgus monkeys.

Haggerty HG, Proctor SJ.

Toxicol Sci. 2012 May;127(1):159-68. doi: 10.1093/toxsci/kfs081.

PMID: 22331490

 

Calcitonin gene-related peptide (CGRP) receptor antagonists: novel aspartates and succinates.

Luo G, Chen L, Pin SS, Xu C, Conway CM, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2912-6. doi: 10.1016/j.bmcl.2012.02.066.

PMID: 22429471

 

Calcitonin gene-related peptide (CGRP) receptor antagonists: pyridine as a replacement for a core amide group.

Luo G, Chen L, Civiello R, Pin SS, Xu C, Kostich W, Kelley M, Conway CM, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2917-21. doi: 10.1016/j.bmcl.2012.02.065.

PMID: 22429470

 

Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.

Ding M, He F, Hudyma TW, Zheng X, Poss MA, Kadow JF, Beno BR, Rigat KL, Wang YK, Fridell RA, Lemm JA, Qiu D, Liu M, Voss S, Pelosi LA, Roberts SB, Gao M, Knipe J, Gentles RG.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2866-71. doi: 10.1016/j.bmcl.2012.02.063.

PMID: 22424979

 

Instrumented roll technology for the design space development of roller compaction process.

Nesarikar VV, Vatsaraj N, Patel C, Early W, Pandey P, Sprockel O, Gao Z, Jerzewski R, Miller R, Levin M.

Int J Pharm. 2012 Apr 15;426(1-2):116-31. doi: 10.1016/j.ijpharm.2012.01.032.

PMID: 22286023

 

Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I(Kur) inhibitor.

Finlay HJ, Lloyd J, Vaccaro W, Kover A, Yan L, Bhave G, Prol J, Huynh T, Bhandaru R, Caringal Y, DiMarco J, Gan J, Harper T, Huang C, Conder ML, Sun H, Levesque P, Blanar M, Atwal K, Wexler R.

J Med Chem. 2012 Apr 12;55(7):3036-48. doi: 10.1021/jm201386u. Erratum in: J Med Chem. 2013 Sep 12;56(17):7133.

PMID: 22409629

 

Single- and multiple-ascending-dose studies of the NS3 protease inhibitor asunaprevir in subjects with or without chronic hepatitis C.

Pasquinelli C, McPhee F, Eley T, Villegas C, Sandy K, Sheridan P, Persson A, Huang SP, Hernandez D, Sheaffer AK, Scola P, Marbury T, Lawitz E, Goldwater R, Rodriguez-Torres M, Demicco M, Wright D, Charlton M, Kraft WK, Lopez-Talavera JC, Grasela DM.

Antimicrob Agents Chemother. 2012 Apr;56(4):1838-44. doi: 10.1128/AAC.05854-11.

PMID: 22290978

 

Evaluation and optimization of compound solubilization and delivery methods in a two-tiered ion channel lead optimization triage.

Hendricson AW, Gallagher L, Matchett M, Ferrante M, Spence S, Paiva T, Shou W, Tertyshnikova S, Krambis M, Post-Munson D, Zhang L, Knox R.

Assay Drug Dev Technol. 2012 Apr;10(2):202-11. doi: 10.1089/adt.2011.0385.

PMID: 22085018

 

Interpersonal interactions, job demands and work-related outcomes in pharmacy.

Gaither CA, Nadkarni A.

Int J Pharm Pract. 2012 Apr;20(2):80-9. doi: 10.1111/j.2042-7174.2011.00165.x.

PMID: 22416932

 

Design of an automated enhanced-throughput platform for functional characterization of positive allosteric modulator-induced leftward shifts in apparent agonist potency in vitro.

Hendricson A, Matchett M, Ferrante M, Ferrante C, Hunnicutt E, Westphal R, Kostich W, Huang Y, Masias N, Hong D, Bertekap R, Burford N, Watson J, Alt A, Myslik J, Zhang L, Knox R.

J Lab Autom. 2012 Apr;17(2):104-15. doi: 10.1177/2211068211435301.

PMID: 22357567

 

Reversible and pH-dependent weak drug-excipient binding does not affect oral bioavailability of high dose drugs.

Narang AS, Yamniuk AP, Zhang L, Comezoglu SN, Bindra DS, Varia S, Doyle ML, Badawy S.

J Pharm Pharmacol. 2012 Apr;64(4):553-65. doi: 10.1111/j.2042-7158.2011.01435.x.

PMID: 22420661

 

Effect of powder substrate on foaml drainage and collapse: implications to foam granulation.

Koo OM, Ji J, Li J.

J Pharm Sci. 2012 Apr;101(4):1385-90. doi: 10.1002/jps.23053.

PMID: 22234920

 

Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.

Zhang D, Flint O, Wang L, Gupta A, Westhouse RA, Zhao W, Raghavan N, Caceres-Cortes J, Marathe P, Shen G, Zhang Y, Allentoff A, Josephs J, Gan J, Borzilleri R, Humphreys WG.

Chem Res Toxicol. 2012 Mar 19;25(3):556-71. doi: 10.1021/tx200524d.

PMID: 22295996

 

Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.

Ross-Macdonald P, de Silva H, Patel V, Truong A, He A, Neuhaus I, Tilford C, Ji R, Siemers N, Greer A, Carboni J, Gottardis M, Menard K, Lee F, Dodier M, Frennesson D, Sampognaro A, Saulnier M, Trainor G, Vyas D, Zimmermann K, Wittman M.

Bioorg Med Chem. 2012 Mar 15;20(6):1961-72. doi: 10.1016/j.bmc.2011.10.090.

PMID: 22137930

 

Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).

Harikrishnan LS, Srivastava N, Kayser LE, Nirschl DS, Kumaragurubaran K, Roy A, Gupta A, Karmakar S, Karatt T, Mathur A, Burford NT, Chen J, Kong Y, Cvijic M, Cooper CB, Poss MA, Trainor GL, Wong TW.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2287-90. doi: 10.1016/j.bmcl.2012.01.082.

PMID: 22365758

 

Liquid chromatography and tandem mass spectrometry method for the quantitative determination of saxagliptin and its major pharmacologically active 5-monohydroxy metabolite in human plasma: method validation and overcoming specific and non-specific binding at low concentrations.

Xu XS, Demers R, Gu H, Christopher LJ, Su H, Cojocaru L, Boulton DW, Kirby M, Stouffer B, Humphreys WG, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 15;889-890:77-86. doi: 10.1016/j.jchromb.2012.01.033.

PMID: 22349123

 

Solid phase synthesis of 1,5-diarylpyrazole-4-carboxamides: discovery of antagonists of the CB-1 receptor.

Pendri A, Dodd DS, Chen J, Cvijic ME, Kang L, Baska RA, Carlson KE, Burford NT, Sun C, Ewing WR, Gerritz SW.

ACS Comb Sci. 2012 Mar 12;14(3):197-204. doi: 10.1021/co200147y.

PMID: 22340081

 

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043).

Kadow JF, Ueda Y, Meanwell NA, Connolly TP, Wang T, Chen CP, Yeung KS, Zhu J, Bender JA, Yang Z, Parker D, Lin PF, Colonno RJ, Mathew M, Morgan D, Zheng M, Chien C, Grasela D.

J Med Chem. 2012 Mar 8;55(5):2048-56. doi: 10.1021/jm201218m.

PMID: 22356441

 

Blindly using Wald's test can miss rare disease-causal variants in case-control association studies.

Xing G, Lin CY, Wooding SP, Xing C.

Ann Hum Genet. 2012 Mar;76(2):168-77. doi: 10.1111/j.1469-1809.2011.00700.x.

PMID: 22256951

 

Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052.

Wang C, Huang H, Valera L, Sun JH, O'Boyle DR 2nd, Nower PT, Jia L, Qiu D, Huang X, Altaf A, Gao M, Fridell RA.

Antimicrob Agents Chemother. 2012 Mar;56(3):1350-8. doi: 10.1128/AAC.05977-11.

PMID: 22214777

 

In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A.

Wang C, Jia L, Huang H, Qiu D, Valera L, Huang X, Sun JH, Nower PT, O'Boyle DR 2nd, Gao M, Fridell RA.

Antimicrob Agents Chemother. 2012 Mar;56(3):1588-90. doi: 10.1128/AAC.06169-11.

PMID: 22203595

 

Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays.

Zhang J, Maloney J, Drexler DM, Cai X, Stewart J, Mayer C, Herbst J, Weller H, Shou WZ.

Bioanalysis. 2012 Mar;4(5):581-93. doi: 10.4155/bio.12.2.

PMID: 22409555

 

Automated and unbiased analysis of LC-MS metabolomic data.

Hnatyshyn S, Shipkova P.

Bioanalysis. 2012 Mar;4(5):541-54. doi: 10.4155/bio.12.9.

PMID: 22409552

 

Integrated quantitative and qualitative workflow for in vivo bioanalytical support in drug discovery using hybrid Q-TOF-MS.

Ranasinghe A, Ramanathan R, Jemal M, D'Arienzo CJ, Humphreys WG, Olah TV.

Bioanalysis. 2012 Mar;4(5):511-28. doi: 10.4155/bio.12.13.

PMID: 22409550

 

HRMS: current usage, future directions and the promise of integration with unified data streams suited to post-acquisition mining.

Josephs JL.

Bioanalysis. 2012 Mar;4(5):471-6. doi: 10.4155/bio.12.17. No abstract available.

PMID: 22409545

 

The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena.

Ramanathan R, Korfmacher W.

Bioanalysis. 2012 Mar;4(5):467-9. doi: 10.4155/bio.12.16. No abstract available.

PMID: 22409544

 

A mechanistic study on the effect of dexamethasone in moderating cell death in Chinese Hamster Ovary cell cultures.

Jing Y, Qian Y, Ghandi M, He A, Borys MC, Pan SH, Li ZJ.

Biotechnol Prog. 2012 Mar-Apr;28(2):490-6. doi: 10.1002/btpr.747.

PMID: 22140034

 

Cost effectiveness of saxagliptin and metformin versus sulfonylurea and metformin in the treatment of type 2 diabetes mellitus in Germany: a Cardiff diabetes model analysis.

Erhardt W, Bergenheim K, Duprat-Lomon I, McEwan P.

Clin Drug Investig. 2012 Mar 1;32(3):189-202. doi: 10.2165/11597060-000000000-00000.

PMID: 22292415

 

Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers.

Tong G, Wang JS, Sverdlov O, Huang SP, Slemmon R, Croop R, Castaneda L, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Dockens RC.

Clin Ther. 2012 Mar;34(3):654-67. doi: 10.1016/j.clinthera.2012.01.022.

PMID: 22381714

 

A modified serial blood sampling technique and utility of dried-blood spot technique in estimation of blood concentration: application in mouse pharmacokinetics.

Kurawattimath V, Pocha K, Mariappan TT, Trivedi RK, Mandlekar S.

Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):23-30. doi: 10.1007/s13318-011-0066-5. Erratum in: Eur J Drug Metab Pharmacokinet. 2011 Dec;36(4):263.

PMID: 21948266

 

Using hydrogen/deuterium exchange mass spectrometry to study conformational changes in granulocyte colony stimulating factor upon PEGylation.

Wei H, Ahn J, Yu YQ, Tymiak A, Engen JR, Chen G.

J Am Soc Mass Spectrom. 2012 Mar;23(3):498-504. doi: 10.1007/s13361-011-0310-x.

PMID: 22227798

 

An active film-coating approach to enhance chemical stability of a potent drug molecule.

Desai D, Rao V, Guo H, Li D, Stein D, Hu FY, Kiesnowski C.

Pharm Dev Technol. 2012 Mar-Apr;17(2):227-35. doi: 10.3109/10837450.2010.531737.

PMID: 21073265

 

Role of patent analysis in corporate R&D.

Barcelon Yang C.

Pharm Pat Anal. 2012 Mar;1(1):5-7. doi: 10.4155/ppa.12.1. No abstract available.

PMID: 24236705

 

Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine.

Luo G, Chen L, Conway CM, Denton R, Keavy D, Gulianello M, Huang Y, Kostich W, Lentz KA, Mercer SE, Schartman R, Signor L, Browning M, Macor JE, Dubowchik GM.

ACS Med Chem Lett. 2012 Feb 27;3(4):337-41. doi: 10.1021/ml300021s.

PMID: 24900474

 

Correlation between gene expression of IGF-1R pathway markers and cetuximab benefit in metastatic colorectal cancer.

Huang F, Xu LA, Khambata-Ford S.

Clin Cancer Res. 2012 Feb 15;18(4):1156-66. doi: 10.1158/1078-0432.CCR-11-1135.

PMID: 22294722

 

Structures of adnectin/protein complexes reveal an expanded binding footprint.

Ramamurthy V, Krystek SR Jr, Bush A, Wei A, Emanuel SL, Das Gupta R, Janjua A, Cheng L, Murdock M, Abramczyk B, Cohen D, Lin Z, Morin P, Davis JH, Dabritz M, McLaughlin DC, Russo KA, Chao G, Wright MC, Jenny VA, Engle LJ, Furfine E, Sheriff S.

Structure. 2012 Feb 8;20(2):259-69. doi: 10.1016/j.str.2011.11.016.

PMID: 22325775

 

 Regioselective synthesis of 1,4-disubstituted imidazoles.

Schmidt MA, Eastgate MD.

Org Biomol Chem. 2012 Feb 7;10(5):1079-87. doi: 10.1039/c1ob06690k.

PMID: 22169998

 

Quantitative analysis of tris(2-carboxyethyl)phosphine by anion-exchange chromatography and evaporative light-scattering detection.

Tan Z, Ihnat PM, Nayak VS, Russell RJ.

J Pharm Biomed Anal. 2012 Feb 5;59:167-72. doi: 10.1016/j.jpba.2011.09.034.

PMID: 22019701

 

Lack of pharmacokinetic interactions between dapagliflozin and simvastatin, valsartan, warfarin, or digoxin.

Kasichayanula S, Chang M, Liu X, Shyu WC, Griffen SC, LaCreta FP, Boulton DW.

Adv Ther. 2012 Feb;29(2):163-77. doi: 10.1007/s12325-011-0098-x.

PMID: 22271159

 

Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2).

Yang MG, Xiao Z, Shi Q, Cherney RJ, Tebben AJ, De Lucca GV, Santella JB 3rd, Mo R, Cvijic ME, Zhao Q, Barrish JC, Carter PH.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1384-7. doi: 10.1016/j.bmcl.2011.12.057.

PMID: 22225639

 

Aripiprazole in combination with lamotrigine for the long-term treatment of patients with bipolar I disorder (manic or mixed): a randomized, multicenter, double-blind study (CN138-392).

Carlson BX, Ketter TA, Sun W, Timko K, McQuade RD, Sanchez R, Vester-Blokland E, Marcus R.

Bipolar Disord. 2012 Feb;14(1):41-53. doi: 10.1111/j.1399-5618.2011.00974.x.

PMID: 22329471

 

Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs.

Whiterock VJ, Morgan DG, Lentz KA, Orcutt TL, Sinz MW.

Drug Metab Dispos. 2012 Feb;40(2):228-31. doi: 10.1124/dmd.111.041848.

PMID: 22074769

 

Pharmacokinetics and inhibitory quotient of atazanavir/ritonavir versus lopinavir/ritonavir in HIV-infected, treatment-naive patients who participated in the CASTLE Study.

Zhu L, Liao S, Child M, Zhang J, Persson A, Sevinsky H, Eley T, Xu X, Krystal M, Farajallah A, McGrath D, Molina JM, Bertz R.

J Antimicrob Chemother. 2012 Feb;67(2):465-8. doi: 10.1093/jac/dkr490.

PMID: 22121190

 

Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2.

Purandare AV, McDevitt TM, Wan H, You D, Penhallow B, Han X, Vuppugalla R, Zhang Y, Ruepp SU, Trainor GL, Lombardo L, Pedicord D, Gottardis MM, Ross-Macdonald P, de Silva H, Hosbach J, Emanuel SL, Blat Y, Fitzpatrick E, Taylor TL, McIntyre KW, Michaud E, Mulligan C, Lee FY, Woolfson A, Lasho TL, Pardanani A, Tefferi A, Lorenzi MV.

Leukemia. 2012 Feb;26(2):280-8. doi: 10.1038/leu.2011.292.

PMID: 22015772

 

A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma: application to a clinical pharmacokinetic study.

Furlong MT, Agrawal S, Hawthorne D, Lago M, Unger S, Krueger L, Stouffer B.

J Pharm Biomed Anal. 2012 Jan 25;58:130-5. doi: 10.1016/j.jpba.2011.09.008.

PMID: 21982905

 

Preliminary study of two antiviral agents for hepatitis C genotype 1.

Lok AS, Gardiner DF, Lawitz E, Martorell C, Everson GT, Ghalib R, Reindollar R, Rustgi V, McPhee F, Wind-Rotolo M, Persson A, Zhu K, Dimitrova DI, Eley T, Guo T, Grasela DM, Pasquinelli C.

N Engl J Med. 2012 Jan 19;366(3):216-24. doi: 10.1056/NEJMoa1104430.

PMID: 22256805

 

Surface energy analysis as a tool to probe the surface energy characteristics of micronized materials--a comparison with inverse gas chromatography.

Gamble JF, Leane M, Olusanmi D, Tobyn M, Supuk E, Khoo J, Naderi M.

Int J Pharm. 2012 Jan 17;422(1-2):238-44. doi: 10.1016/j.ijpharm.2011.11.002.

PMID: 22100516

 

Q-TWiST analysis of ixabepilone in combination with capecitabine on quality of life in patients with metastatic breast cancer.

Corey-Lisle PK, Peck R, Mukhopadhyay P, Orsini L, Safikhani S, Bell JA, Hortobagyi G, Roche H, Conte P, Revicki DA.

Cancer. 2012 Jan 15;118(2):461-8. doi: 10.1002/cncr.26213.

PMID: 21598243

 

A mechanistic study on the amidation of esters mediated by sodium formamide.

Ramirez A, Mudryk B, Rossano L, Tummala S.

J Org Chem. 2012 Jan 6;77(1):775-9. doi: 10.1021/jo2021828.

PMID: 22087875

 

AlMe(3)-promoted formation of amides from acids and amines.

Li J, Subramaniam K, Smith D, Qiao JX, Li JJ, Qian-Cutrone J, Kadow JF, Vite GD, Chen BC.

Org Lett. 2012 Jan 6;14(1):214-7. doi: 10.1021/ol203007s.

PMID: 22148911

 

Discovery of a Novel Class of Bicyclo[3.1.0]hexanylpiperazines as Noncompetitive Neuropeptide Y Y1 Antagonists.

Hu S, Huang Y, Deshpande M, Luo G, Bruce MA, Chen L, Mattson G, Iben LG, Zhang J, Russell JW, Clarke WJ, Hogan JB, Ortiz A, Flint O, Henwood A, Gao Q, Antal-Zimanyi I, Poindexter GS.

ACS Med Chem Lett. 2012 Jan 4;3(3):222-6. doi: 10.1021/ml200265m.

PMID: 24900458

 

Quantitation of therapeutic proteins following direct trypsin digestion of dried blood spot samples and detection by LC-MS-based bioanalytical methods in drug discovery.

Sleczka BG, D'Arienzo CJ, Tymiak AA, Olah TV.

Bioanalysis. 2012 Jan;4(1):29-40. doi: 10.4155/bio.11.293.

PMID: 22191592

 

Pellet digestion: a simple and efficient sample preparation technique for LC-MS/MS quantification of large therapeutic proteins in plasma.

Ouyang Z, Furlong MT, Wu S, Sleczka B, Tamura J, Wang H, Suchard S, Suri A, Olah T, Tymiak A, Jemal M.

Bioanalysis. 2012 Jan;4(1):17-28. doi: 10.4155/bio.11.286.

PMID: 22191591

 

In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin.

Gan J, Liu-Kreyche P, Humphreys WG.

Cancer Chemother Pharmacol. 2012 Jan;69(1):51-6. doi: 10.1007/s00280-011-1672-2.

PMID: 21594721

 

Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus.

Whaley JM, Tirmenstein M, Reilly TP, Poucher SM, Saye J, Parikh S, List JF.

Diabetes Metab Syndr Obes. 2012;5:135-48. doi: 10.2147/DMSO.S22503.

PMID: 22923998

 

Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib.

Gong J, Gan J, Iyer RA.

Drug Metab Dispos. 2012 Jan;40(1):219-26. doi: 10.1124/dmd.111.042457.

PMID: 21989950

 

Evaporative light scattering detection based HPLC method for the determination of polysorbate 80 in therapeutic protein formulations.

Nayak VS, Tan Z, Ihnat PM, Russell RJ, Grace MJ.

J Chromatogr Sci. 2012 Jan;50(1):21-5. doi: 10.1093/chromsci/bmr015.

PMID: 22291052

 

A pharmacometric approach to quantify the impact of chronic kidney disease and hemodialysis on systemic drug exposure: application to saxagliptin.

Zhang L, Boulton DW, Pfister M.

J Clin Pharmacol. 2012 Jan;52(1 Suppl):126S-33S. doi: 10.1177/0091270011415627.

PMID: 22232748

 

Inferences on Small Area Proportions.

Chen S, Lahiri P.

J Indian Soc Agric Stat. 2012;66(1):121-124.

PMID: 24453380

 

Association between second-generation antipsychotic medication half-life and hospitalization in the community treatment of adult schizophrenia.

Broder MS, Bates JA, Jing Y, Hebden T, Forbes RA, Chang E.

J Med Econ. 2012;15(1):105-11. doi: 10.3111/13696998.2011.632042.

PMID: 21991926

 

Measurement of Aβ1-42 in cerebrospinal fluid is influenced by matrix effects.

Slemmon JR, Meredith J, Guss V, Andreasson U, Andreasen N, Zetterberg H, Blennow K.

J Neurochem. 2012 Jan;120(2):325-33. doi: 10.1111/j.1471-4159.2011.07553.x.

PMID: 22023354

 

Effect of antioxidants and silicates on peroxides in povidone.

Narang AS, Rao VM, Desai DS.

J Pharm Sci. 2012 Jan;101(1):127-39. doi: 10.1002/jps.22729.

PMID: 22109686

 

Size-exclusion chromatography with multi-angle light scattering for elucidating protein aggregation mechanisms.

Sahin E, Roberts CJ.

Methods Mol Biol. 2012;899:403-23. doi: 10.1007/978-1-61779-921-1_25. Review.

PMID: 22735967

 

Zebrafish embryo developmental toxicology assay.

Panzica-Kelly JM, Zhang CX, Augustine-Rauch K.

Methods Mol Biol. 2012;889:25-50. doi: 10.1007/978-1-61779-867-2_4.

PMID: 22669658

 

High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.

Wichroski MJ, Fang J, Eggers BJ, Rose RE, Mazzucco CE, Pokornowski KA, Baldick CJ, Anthony MN, Dowling CJ, Barber LE, Leet JE, Beno BR, Gerritz SW, Agler ML, Cockett MI, Tenney DJ.

PLoS One. 2012;7(8):e42609. doi: 10.1371/journal.pone.0042609.

PMID: 22880053

 

Virologic failures on initial boosted-PI regimen infrequently possess low-level variants with major PI resistance mutations by ultra-deep sequencing.

Lataillade M, Chiarella J, Yang R, DeGrosky M, Uy J, Seekins D, Simen B, St John E, Moreno E, Kozal M.

PLoS One. 2012;7(2):e30118. doi: 10.1371/journal.pone.0030118.

PMID: 22355307

 

Improvement in functional outcomes with adjunctive aripiprazole versus placebo in major depressive disorder: a pooled post hoc analysis of 3 short-term studies.

Fabian TJ, Cain ZJ, Ammerman D, Eudicone JM, Tang Y, Rollin LM, Forbes RA, Berman RM, Baker RA.

Prim Care Companion CNS Disord. 2012;14(6). pii: PCC.12m01394. doi: 10.4088/PCC.12m01394.

PMID: 23585999

 

Beneficial effects of adjunctive aripiprazole in major depressive disorder are not dependent on antidepressant therapy history: a post hoc analysis of 3 randomized, double-blind, placebo-controlled trials.

Dunner DL, Laubmeier KK, Manos G, Forbes RA, Baker RA, Berman RM.

Prim Care Companion CNS Disord. 2012;14(6). pii: PCC.12m01380. doi: 10.4088/PCC.12m01380.

PMID: 23585997

 

Fifty years of "the pill": risk reduction and discovery of benefits beyond contraception, reflections, and forecast.

Chadwick KD, Burkman RT, Tornesi BM, Mahadevan B.

Toxicol Sci. 2012 Jan;125(1):2-9. doi: 10.1093/toxsci/kfr242.

PMID: 21940817

Back to Top

2011 Publications

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.

Munchhof MJ, Li Q, Shavnya A, Borzillo GV, Boyden TL, Jones CS, LaGreca SD, Martinez-Alsina L, Patel N, Pelletier K, Reiter LA, Robbins MD, Tkalcevic GT.

ACS Med Chem Lett. 2011 Dec 21;3(2):106-11. doi: 10.1021/ml2002423.

PMID: 24900436

 

Communication: Quantum polarized fluctuating charge model: a practical method to include ligand polarizability in biomolecular simulations.

Kimura SR, Rajamani R, Langley DR.

J Chem Phys. 2011 Dec 21;135(23):231101. doi: 10.1063/1.3671638.

PMID: 22191857

 

Kinetic and mechanistic insight into the thermodynamic degradation of saxagliptin.

Jones GS, Savage SA, Ivy S, Benitez PL, Ramirez A.

J Org Chem. 2011 Dec 16;76(24):10332-7. doi: 10.1021/jo202052a. Erratum in: J Org Chem. 2013 May 3;78(9):4627.

PMID: 22054301

 

Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.

Shi Y, O'Connor SP, Sitkoff D, Zhang J, Shi M, Bisaha SN, Wang Y, Li C, Ruan Z, Lawrence RM, Klei HE, Kish K, Liu EC, Seiler SM, Schweizer L, Steinbacher TE, Schumacher WA, Robl JA, Macor JE, Atwal KS, Stein PD.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7516-21. doi: 10.1016/j.bmcl.2011.06.098.

PMID: 22041058

 

Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients.

Goldhaber SZ, Leizorovicz A, Kakkar AK, Haas SK, Merli G, Knabb RM, Weitz JI; ADOPT Trial Investigators..

N Engl J Med. 2011 Dec 8;365(23):2167-77. doi: 10.1056/NEJMoa1110899.

PMID: 22077144

 

A high-throughput spectrophotometric approach for evaluation of precipitation resistance.

Chandran S, Gesenberg C, Levons J, Hubert M, Raghavan K.

J Pharm Biomed Anal. 2011 Dec 5;56(4):698-704. doi: 10.1016/j.jpba.2011.07.009.

PMID: 21816556

 

Reactive impurities in excipients: profiling, identification and mitigation of drug-excipient incompatibility.

Wu Y, Levons J, Narang AS, Raghavan K, Rao VM.

AAPS PharmSciTech. 2011 Dec;12(4):1248-63. doi: 10.1208/s12249-011-9677-z. Review.

PMID: 21948318

 

Approach to evaluating dried blood spot sample stability during drying process and discovery of a treated card to maintain analyte stability by rapid on-card pH modification.

Liu G, Ji QC, Jemal M, Tymiak AA, Arnold ME.

Anal Chem. 2011 Dec 1;83(23):9033-8. doi: 10.1021/ac2023876.

PMID: 21995953

 

Strategy and its implications of protein bioanalysis utilizing high-resolution mass spectrometric detection of intact protein.

Ruan Q, Ji QC, Arnold ME, Humphreys WG, Zhu M.

Anal Chem. 2011 Dec 1;83(23):8937-44. doi: 10.1021/ac201540t.

PMID: 21970614

 

Model-based approach for optimization of atazanavir dose recommendations for HIV-infected pediatric patients.

Hong Y, Kowalski KG, Zhang J, Zhu L, Horga M, Bertz R, Pfister M, Roy A.

Antimicrob Agents Chemother. 2011 Dec;55(12):5746-52. doi: 10.1128/AAC.00554-11.

PMID: 21930880

 

Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).

Watterson SH, Langevine CM, Van Kirk K, Kempson J, Guo J, Spergel SH, Das J, Moquin RV, Dyckman AJ, Nirschl D, Gregor K, Pattoli MA, Yang X, McIntyre KW, Yang G, Galella MA, Booth-Lute H, Chen L, Yang Z, Wang-Iverson D, McKinnon M, Dodd JH, Barrish JC, Burke JR, Pitts WJ.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7006-12. doi: 10.1016/j.bmcl.2011.09.111.

PMID: 22018461

 

Studies to further investigate the inhibition of human liver microsomal CYP2C8 by the acyl-β-glucuronide of gemfibrozil.

Jenkins SM, Zvyaga T, Johnson SR, Hurley J, Wagner A, Burrell R, Turley W, Leet JE, Philip T, Rodrigues AD.

Drug Metab Dispos. 2011 Dec;39(12):2421-30. doi: 10.1124/dmd.111.041947.

PMID: 21911547

 

Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1.

Nettles RE, Gao M, Bifano M, Chung E, Persson A, Marbury TC, Goldwater R, DeMicco MP, Rodriguez-Torres M, Vutikullird A, Fuentes E, Lawitz E, Lopez-Talavera JC, Grasela DM.

Hepatology. 2011 Dec;54(6):1956-65. doi: 10.1002/hep.24609.

PMID: 21837752

 

Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.

Fridell RA, Wang C, Sun JH, O'Boyle DR 2nd, Nower P, Valera L, Qiu D, Roberts S, Huang X, Kienzle B, Bifano M, Nettles RE, Gao M.

Hepatology. 2011 Dec;54(6):1924-35. doi: 10.1002/hep.24594.

PMID: 21809362

 

Model-based determination of abatacept exposure in support of the recommended dose for Japanese rheumatoid arthritis patients.

Hasegawa M, Imai Y, Hiraoka M, Ito K, Roy A.

J Pharmacokinet Pharmacodyn. 2011 Dec;38(6):803-32. doi: 10.1007/s10928-011-9221-5.

PMID: 22002809

 

Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications.

Arey BJ, López FJ.

Rev Endocr Metab Disord. 2011 Dec;12(4):275-88. doi: 10.1007/s11154-011-9188-y. Review.

PMID: 21706143

 

Evaluation and validation of multiple cell lines and primary mouse macrophages to predict phospholipidosis potential.

LeCureux L, Cheng CS, Herbst J, Reilly TP, Lehman-McKeeman L, Otieno M.

Toxicol In Vitro. 2011 Dec;25(8):1934-43. doi: 10.1016/j.tiv.2011.06.017.

PMID: 21767630

 

Bioanalytical strategies for developing highly sensitive liquid chromatography/tandem mass spectrometry based methods for the peptide GLP-1 agonists in support of discovery PK/PD studies.

Zhang H, Xin B, Caporuscio C, Olah TV.

Rapid Commun Mass Spectrom. 2011 Nov 30;25(22):3427-35. doi: 10.1002/rcm.5241.

PMID: 22002697

 

7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site.

Wang W, Devasthale P, Wang A, Harrity T, Egan D, Morgan N, Cap M, Fura A, Klei HE, Kish K, Weigelt C, Sun L, Levesque P, Li YX, Zahler R, Kirby MS, Hamann LG.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6646-51. doi: 10.1016/j.bmcl.2011.09.074.

PMID: 21996520

 

Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1).

Wu SC, Yoon D, Chin J, van Kirk K, Seethala R, Golla R, He B, Harrity T, Kunselman LK, Morgan NN, Ponticiello RP, Taylor JR, Zebo R, Harper TW, Li W, Wang M, Zhang L, Sleczka BG, Nayeem A, Sheriff S, Camac DM, Morin PE, Everlof JG, Li YX, Ferraro CA, Kieltyka K, Shou W, Vath MB, Zvyaga TA, Gordon DA, Robl JA.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6693-8. doi: 10.1016/j.bmcl.2011.09.058.

PMID: 21983444

 

Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

Ye XY, Chen SY, Nayeem A, Golla R, Seethala R, Wang M, Harper T, Sleczka BG, Li YX, He B, Kirby M, Gordon DA, Robl JA.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6699-704. doi: 10.1016/j.bmcl.2011.09.055.

PMID: 21983439

 

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

Thompson LA, Shi J, Decicco CP, Tebben AJ, Olson RE, Boy KM, Guernon JM, Good AC, Liauw A, Zheng C, Copeland RA, Combs AP, Trainor GL, Camac DM, Muckelbauer JK, Lentz KA, Grace JE, Burton CR, Toyn JH, Barten DM, Marcinkeviciene J, Meredith JE, Albright CF, Macor JE.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6909-15. doi: 10.1016/j.bmcl.2011.06.116.

PMID: 21974952

 

Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.

Yang Y, Miller KJ, Zhu Y, Hong Y, Tian Y, Murugesan N, Gu Z, O'Tanyi E, Keim WJ, Rohrbach KW, Johnghar S, Behnia K, Pelleymounter MA, Carlson KE, Ewing WR.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6856-60. doi: 10.1016/j.bmcl.2011.09.016.

PMID: 21962575

 

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).

Boy KM, Guernon JM, Shi J, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Marcinkeviciene J, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Lentz KA, Bronson JJ, Olson RE, Macor JE, Thompson LA 3rd.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6916-24. doi: 10.1016/j.bmcl.2011.06.109.

PMID: 21782431

 

Quantitative estimation of circulating metabolites without synthetic standards by ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry in combination with UV correction.

Yang Y, Grubb MF, Luk CE, Humphreys WG, Josephs JL.

Rapid Commun Mass Spectrom. 2011 Nov 15;25(21):3245-51. doi: 10.1002/rcm.5220.

PMID: 22006386

 

Characterization of glycosylation sites for a recombinant IgG1 monoclonal antibody and a CTLA4-Ig fusion protein by liquid chromatography-mass spectrometry peptide mapping.

Bongers J, Devincentis J, Fu J, Huang P, Kirkley DH, Leister K, Liu P, Ludwig R, Rumney K, Tao L, Wu W, Russell RJ.

J Chromatogr A. 2011 Nov 11;1218(45):8140-9. doi: 10.1016/j.chroma.2011.08.089.

PMID: 21978954

 

Treatment of advanced HIV disease in antiretroviral-naïve HIV-1-infected patients receiving once-daily atazanavir/ritonavir or twice-daily lopinavir/ritonavir, each in combination with tenofovir disoproxil fumarate and emtricitabine.

Uy J, Yang R, Wirtz V, Sheppard L, Farajallah A, McGrath D.

AIDS Care. 2011 Nov;23(11):1500-4. doi: 10.1080/09540121.2011.565033.

PMID: 21732894

 

The importance of HT-ADME in drug discovery.

Morgan D.

Bioanalysis. 2011 Nov;3(21):2385-7. doi: 10.4155/bio.11.253.

PMID: 22074279

 

The effects of age and gender on the pharmacokinetics and pharmacodynamics in healthy subjects of the plasminogen activator, lanoteplase.

Vachharajani NN, Raymond RH, Shyu WC, Stouffer BC, Boulton DW.

Br J Clin Pharmacol. 2011 Nov;72(5):775-86. doi: 10.1111/j.1365-2125.2011.04003.x.

PMID: 21545481

 

X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase.

Muckelbauer J, Sack JS, Ahmed N, Burke J, Chang CY, Gao M, Tino J, Xie D, Tebben AJ.

Chem Biol Drug Des. 2011 Nov;78(5):739-48. doi: 10.1111/j.1747-0285.2011.01230.x.

PMID: 21883956

 

Influence of hepatic impairment on the pharmacokinetics and safety profile of dapagliflozin: an open-label, parallel-group, single-dose study.

Kasichayanula S, Liu X, Zhang W, Pfister M, LaCreta FP, Boulton DW.

Clin Ther. 2011 Nov;33(11):1798-808. doi: 10.1016/j.clinthera.2011.09.011.

PMID: 22030444

 

Incidence of serious upper and lower gastrointestinal events in older adults with and without Alzheimer's disease.

Wu JH, Guo Z, Kumar S, Lapuerta P.

J Am Geriatr Soc. 2011 Nov;59(11):2053-61. doi: 10.1111/j.1532-5415.2011.03667.x.

PMID: 22091628

 

Regeneration of tetrabutylammonium ion-pairing reagent distribution in a gradient elution of reversed phase ion-pair chromatography.

Zhang J, Raglione T, Wang Q, Kleintop B, Tomasella F, Liang X.

J Chromatogr Sci. 2011 Nov-Dec;49(10):825-31.

PMID: 22080812

 

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

Qiu D, Lemm JA, O'Boyle DR 2nd, Sun JH, Nower PT, Nguyen V, Hamann LG, Snyder LB, Deon DH, Ruediger E, Meanwell NA, Belema M, Gao M, Fridell RA.

J Gen Virol. 2011 Nov;92(Pt 11):2502-11. doi: 10.1099/vir.0.034801-0.

PMID: 21795470

 

Physical stability and recrystallization kinetics of amorphous ibipinabant drug product by fourier transform raman spectroscopy.

Sinclair W, Leane M, Clarke G, Dennis A, Tobyn M, Timmins P.

J Pharm Sci. 2011 Nov;100(11):4687-99. doi: 10.1002/jps.22658.

PMID: 21681752

 

Phase behavior of TPGS-PEG400/1450 systems and their application to liquid formulation: a formulation platform approach.

Li J, Yang B, Levons J, Pinnamaneni S, Raghavan K.

J Pharm Sci. 2011 Nov;100(11):4907-21. doi: 10.1002/jps.22659.

PMID: 21656767

 

Dissecting the activation of thienopyridines by cytochromes P450 using a pharmacodynamic assay in vitro.

Abell LM, Liu EC.

J Pharmacol Exp Ther. 2011 Nov;339(2):589-96. doi: 10.1124/jpet.111.184895.

PMID: 21828263

 

Selective MMP13 inhibitors.

Li JJ, Johnson AR.

Med Res Rev. 2011 Nov;31(6):863-94. doi: 10.1002/med.20204. Review.

PMID: 20196103

 

Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy.

Roongta UV, Pabalan JG, Wang X, Ryseck RP, Fargnoli J, Henley BJ, Yang WP, Zhu J, Madireddi MT, Lawrence RM, Wong TW, Rupnow BA.

Mol Cancer Res. 2011 Nov;9(11):1551-61. doi: 10.1158/1541-7786.MCR-11-0126.

PMID: 21954435

 

Examining determinants of self management behaviors in patients with diabetes: an application of the Theoretical Model of Effortful Decision Making and Enactment.

Nadkarni A, Kucukarslan SN, Bagozzi RP, Yates JF, Erickson SR.

Patient Educ Couns. 2011 Nov;85(2):148-53. doi: 10.1016/j.pec.2010.09.027.

PMID: 21041057

 

Optimal response-adaptive randomized designs for multi-armed survival trials.

Sverdlov O, Tymofyeyev Y, Wong WK.

Stat Med. 2011 Oct 30;30(24):2890-910. doi: 10.1002/sim.4331.

PMID: 21823146

 

Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791826).

Weinstein DS, Gong H, Doweyko AM, Cunningham M, Habte S, Wang JH, Holloway DA, Burke C, Gao L, Guarino V, Carman J, Somerville JE, Shuster D, Salter-Cid L, Dodd JH, Nadler SG, Barrish JC.

J Med Chem. 2011 Oct 27;54(20):7318-33. doi: 10.1021/jm200879j.

PMID: 21899328

 

SDRS--an algorithm for analyzing large-scale dose-response data.

Ji RR, Siemers NO, Lei M, Schweizer L, Bruccoleri RE.

Bioinformatics. 2011 Oct 15;27(20):2921-3. doi: 10.1093/bioinformatics/btr489.

PMID: 21865301

 

Targeted quantitative bioanalysis in plasma using liquid chromatography/high-resolution accurate mass spectrometry: an evaluation of global selectivity as a function of mass resolving power and extraction window, with comparison of centroid and profile modes.

Xia YQ, Lau J, Olah T, Jemal M.

Rapid Commun Mass Spectrom. 2011 Oct 15;25(19):2863-78. doi: 10.1002/rcm.5178.

PMID: 21913265

 

Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.

Sheriff S, Beno BR, Zhai W, Kostich WA, McDonnell PA, Kish K, Goldfarb V, Gao M, Kiefer SE, Yanchunas J, Huang Y, Shi S, Zhu S, Dzierba C, Bronson J, Macor JE, Appiah KK, Westphal RS, O'Connell J, Gerritz SW.

J Med Chem. 2011 Oct 13;54(19):6548-62. doi: 10.1021/jm2003766.

PMID: 21882820

 

The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase.

Ding M, He F, Poss MA, Rigat KL, Wang YK, Roberts SB, Qiu D, Fridell RA, Gao M, Gentles RG.

Org Biomol Chem. 2011 Oct 7;9(19):6654-62. doi: 10.1039/c1ob05525a.

PMID: 21800000

 

Development of a cyclic adenosine monophosphate assay for Gi-coupled G protein-coupled receptors by utilizing the endogenous calcitonin activity in Chinese hamster ovary cells.

Wang Y, Kong Y, Shei GJ, Kang L, Cvijic ME.

Assay Drug Dev Technol. 2011 Oct;9(5):522-31. doi: 10.1089/adt.2010.0361.

PMID: 21561374

 

Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC-HRMS for the quantitation of prednisone and prednisolone in human plasma.

Fung EN, Xia YQ, Aubry AF, Zeng J, Olah T, Jemal M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Oct 1;879(27):2919-27. doi: 10.1016/j.jchromb.2011.08.025.

PMID: 21907643

 

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: prediction of plasma concentration-time profiles in human from in vivo preclinical data by using the Wajima approach.

Vuppugalla R, Marathe P, He H, Jones RD, Yates JW, Jones HM, Gibson CR, Chien JY, Ring BJ, Adkison KK, Ku MS, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Poulin P.

J Pharm Sci. 2011 Oct;100(10):4111-26. doi: 10.1002/jps.22551.

PMID: 21480234

 

The effect of PEGylation on the stability of small therapeutic proteins.

Palm T, Esfandiary R, Gandhi R.

Pharm Dev Technol. 2011 Oct;16(5):441-8. doi: 10.3109/10837450.2010.535830.

PMID: 21261458

 

Investigation into the impact of sub-populations of agglomerates on the particle size distribution and flow properties of conventional microcrystalline cellulose grades.

Gamble JF, Chiu WS, Tobyn M.

Pharm Dev Technol. 2011 Oct;16(5):542-8. doi: 10.3109/10837450.2010.495395.

PMID: 20565228

 

Pitfalls in meta-analyses on adverse events reported from clinical trials.

Huang HY, Andrews E, Jones J, Skovron ML, Tilson H.

Pharmacoepidemiol Drug Saf. 2011 Oct;20(10):1014-20. doi: 10.1002/pds.2208.

PMID: 21858897

 

Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.

Meanwell NA.

Chem Res Toxicol. 2011 Sep 19;24(9):1420-56. doi: 10.1021/tx200211v. Review.

PMID: 21790149

 

Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis.

Goodenough AK, Onorato JM, Ouyang Z, Chang S, Rodrigues AD, Kasichayanula S, Huang SP, Turley W, Burrell R, Bifano M, Jemal M, LaCreta F, Tymiak A, Wang-Iverson D.

Chem Res Toxicol. 2011 Sep 19;24(9):1575-85. doi: 10.1021/tx2001898.

PMID: 21728364

 

Apixaban versus warfarin in patients with atrial fibrillation.

Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L; ARISTOTLE Committees and Investigators..

N Engl J Med. 2011 Sep 15;365(11):981-92. doi: 10.1056/NEJMoa1107039.

PMID: 21870978

 

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.

Gerritz SW, Cianci C, Kim S, Pearce BC, Deminie C, Discotto L, McAuliffe B, Minassian BF, Shi S, Zhu S, Zhai W, Pendri A, Li G, Poss MA, Edavettal S, McDonnell PA, Lewis HA, Maskos K, Mörtl M, Kiefersauer R, Steinbacher S, Baldwin ET, Metzler W, Bryson J, Healy MD, Philip T, Zoeckler M, Schartman R, Sinz M, Leyva-Grado VH, Hoffmann HH, Langley DR, Meanwell NA, Krystal M.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15366-71. doi: 10.1073/pnas.1107906108.

PMID: 21896751

 

Prevalence and outcome of HIV-associated malignancies among children.

Tukei VJ, Kekitiinwa A, Beasley RP.

AIDS. 2011 Sep 10;25(14):1789-93. doi: 10.1097/QAD.0b013e3283498115.

PMID: 21673560

 

Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.

Ly VT, Brock B.

Chem Biol Interact. 2011 Sep 5;193(2):109-18. doi: 10.1016/j.cbi.2011.05.011.

PMID: 21741958

 

A retrospective study of HIV antiretroviral treatment persistence in a commercially insured population in the United States.

Juday T, Grimm K, Zoe-Powers A, Willig J, Kim E.

AIDS Care. 2011 Sep;23(9):1154-62. doi: 10.1080/09540121.2010.543884.

PMID: 21500025

 

Effects of the H2-receptor antagonist famotidine on the pharmacokinetics of atazanavir-ritonavir with or without tenofovir in HIV-infected patients.

Wang X, Boffito M, Zhang J, Chung E, Zhu L, Wu Y, Patterson K, Kashuba A, Tebas P, Child M, Mahnke L, Bertz R.

AIDS Patient Care STDS. 2011 Sep;25(9):509-15. doi: 10.1089/apc.2011.0113.

PMID: 21770762

 

Preannealing of poly(A) template and oligo(dT) primer is not required for hepatitis C virus RNA-dependent RNA polymerase activity.

Wang YK.

Anal Biochem. 2011 Sep 1;416(1):132-4. doi: 10.1016/j.ab.2011.04.019.

PMID: 21565152

 

Intent-to-treat analysis of health care expenditures of patients treated with atypical antipsychotics as adjunctive therapy in depression.

Jing Y, Kalsekar I, Curkendall SM, Carls GS, Bagalman E, Forbes RA, Hebden T, Thase ME.

Clin Ther. 2011 Sep;33(9):1246-57. doi: 10.1016/j.clinthera.2011.07.015.

PMID: 21840058

 

1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase.

Sun Q, Harper TW, Dierks EA, Zhang L, Chang S, Rodrigues AD, Marathe P.

Drug Metab Dispos. 2011 Sep;39(9):1674-9. doi: 10.1124/dmd.111.039834.

PMID: 21677062

 

In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor.

Hong H, Su H, Ma L, Yao M, Iyer RA, Humphreys WG, Christopher LJ.

Drug Metab Dispos. 2011 Sep;39(9):1658-67. doi: 10.1124/dmd.111.039776.

PMID: 21673131

 

Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor.

He K, Luettgen JM, Zhang D, He B, Grace JE Jr, Xin B, Pinto DJ, Wong PC, Knabb RM, Lam PY, Wexler RR, Grossman SJ.

Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):129-39. doi: 10.1007/s13318-011-0037-x.

PMID: 21461793

 

Determination of rifabutin dosing regimen when administered in combination with ritonavir-boosted atazanavir.

Zhang J, Zhu L, Stonier M, Coumbis J, Xu X, Wu Y, Arikan D, Farajallah A, Bertz R.

J Antimicrob Chemother. 2011 Sep;66(9):2075-82. doi: 10.1093/jac/dkr266.

PMID: 21712242

 

Safety and tolerability of aripiprazole for irritability in pediatric patients with autistic disorder: a 52-week, open-label, multicenter study.

Marcus RN, Owen R, Manos G, Mankoski R, Kamen L, McQuade RD, Carson WH, Findling RL.

J Clin Psychiatry. 2011 Sep;72(9):1270-6. doi: 10.4088/JCP.09m05933.

PMID: 21813076

 

Vacuum decay container closure integrity leak test method development and validation for a lyophilized product-package system.

Patel J, Mulhall B, Wolf H, Klohr S, Guazzo DM.

PDA J Pharm Sci Technol. 2011 Sep-Oct;65(5):486-505. doi: 10.5731/pdajpst.2011.00780.

PMID: 22293838

 

Development of a two-step tier-2 dissolution method for blinded overencapsulated erlotinib tablets using UV fiber optic detection.

Lu X, Xiao B, Lo L, Bolgar MS, Lloyd DK.

J Pharm Biomed Anal. 2011 Aug 25;56(1):23-9. doi: 10.1016/j.jpba.2011.04.026.

PMID: 21620602

 

Apixaban with antiplatelet therapy after acute coronary syndrome.

Alexander JH, Lopes RD, James S, Kilaru R, He Y, Mohan P, Bhatt DL, Goodman S, Verheugt FW, Flather M, Huber K, Liaw D, Husted SE, Lopez-Sendon J, De Caterina R, Jansky P, Darius H, Vinereanu D, Cornel JH, Cools F, Atar D, Leiva-Pons JL, Keltai M, Ogawa H, Pais P, Parkhomenko A, Ruzyllo W, Diaz R, White H, Ruda M, Geraldes M, Lawrence J, Harrington RA, Wallentin L; APPRAISE-2 Investigators..

N Engl J Med. 2011 Aug 25;365(8):699-708. doi: 10.1056/NEJMoa1105819.

PMID: 21780946

 

Opportunities and challenges in the development of experimental drug combinations for cancer.

Humphrey RW, Brockway-Lunardi LM, Bonk DT, Dohoney KM, Doroshow JH, Meech SJ, Ratain MJ, Topalian SL, Pardoll DM.

J Natl Cancer Inst. 2011 Aug 17;103(16):1222-6. doi: 10.1093/jnci/djr246.

PMID: 21765011

 

A convenient strategy for quantitative determination of drug concentrations in tissue homogenates using a liquid chromatography/tandem mass spectrometry assay for plasma samples.

Jiang H, Zeng J, Zheng N, Kandoussi H, Peng Q, Valentine JL, Lange RW, Arnold ME.

Anal Chem. 2011 Aug 15;83(16):6237-44. doi: 10.1021/ac200820q.

PMID: 21692511

 

Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α.

Pedicord DL, Flynn MJ, Fanslau C, Miranda M, Hunihan L, Robertson BJ, Pearce BC, Yu XC, Westphal RS, Blat Y.

Biochem Biophys Res Commun. 2011 Aug 12;411(4):809-14. doi: 10.1016/j.bbrc.2011.07.037.

PMID: 21787747

 

Modifying conventional high-performance liquid chromatography systems to achieve fast separations with Fused-Core columns: a case study.

Alexander AJ, Waeghe TJ, Himes KW, Tomasella FP, Hooker TF.

J Chromatogr A. 2011 Aug 12;1218(32):5456-69. doi: 10.1016/j.chroma.2011.06.026.

PMID: 21742337

 

Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures.

Lemm JA, Leet JE, O'Boyle DR 2nd, Romine JL, Huang XS, Schroeder DR, Alberts J, Cantone JL, Sun JH, Nower PT, Martin SW, Serrano-Wu MH, Meanwell NA, Snyder LB, Gao M.

Antimicrob Agents Chemother. 2011 Aug;55(8):3795-802. doi: 10.1128/AAC.00146-11.

PMID: 21576451

 

LC-MS/MS bioanalytical challenge: ultra-high sensitivity assays.

Aubry AF.

Bioanalysis. 2011 Aug;3(16):1819-25. doi: 10.4155/bio.11.166. Review.

PMID: 21877891

 

Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.

Dyckman AJ, Li T, Pitt S, Zhang R, Shen DR, McIntyre KW, Gillooly KM, Shuster DJ, Doweyko AM, Sack JS, Kish K, Kiefer SE, Newitt JA, Zhang H, Marathe PH, McKinnon M, Barrish JC, Dodd JH, Schieven GL, Leftheris K.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4633-7. doi: 10.1016/j.bmcl.2011.05.091.

PMID: 21705217

 

Effect of a high-fat meal on the pharmacokinetics of dapagliflozin, a selective SGLT2 inhibitor, in healthy subjects.

Kasichayanula S, Liu X, Zhang W, Pfister M, Reele SB, Aubry AF, LaCreta FP, Boulton DW.

Diabetes Obes Metab. 2011 Aug;13(8):770-3. doi: 10.1111/j.1463-1326.2011.01397.x.

PMID: 21435141

 

New first and second generation inhibitors of human immunodeficiency virus-1 integrase.

Pendri A, Meanwell NA, Peese KM, Walker MA.

Expert Opin Ther Pat. 2011 Aug;21(8):1173-89. doi: 10.1517/13543776.2011.586631. Review.

PMID: 21599420

 

Young mania rating scale line item analysis in pediatric subjects with bipolar I disorder treated with aripiprazole in a short-term, double-blind, randomized study.

Mankoski R, Zhao J, Carson WH, Mathew SJ, Forbes RA.

J Child Adolesc Psychopharmacol. 2011 Aug;21(4):359-64. doi: 10.1089/cap.2010.0100

PMID: 21823911

 

Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma.

Luettgen JM, Knabb RM, He K, Pinto DJ, Rendina AR.

J Enzyme Inhib Med Chem. 2011 Aug;26(4):514-26. doi: 10.3109/14756366.2010.535793.

PMID: 21171894

 

A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits.

Wong PC, Crain EJ, Watson CA, Schumacher WA.

J Thromb Thrombolysis. 2011 Aug;32(2):129-37. doi: 10.1007/s11239-011-0599-0.

PMID: 21614454

 

Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.

Gong L, Aranibar N, Han YH, Zhang Y, Lecureux L, Bhaskaran V, Khandelwal P, Klaassen CD, Lehman-McKeeman LD.

Toxicol Sci. 2011 Aug;122(2):587-97. doi: 10.1093/toxsci/kfr114.

PMID: 21561886

 

Drug metabolite profiling and identification by high-resolution mass spectrometry.

Zhu M, Zhang H, Humphreys WG.

J Biol Chem. 2011 Jul 22;286(29):25419-25. doi: 10.1074/jbc.R110.200055. Review.

PMID: 21632546

 

Role of tumor vascular architecture in drug delivery.

Narang AS, Varia S.

Adv Drug Deliv Rev. 2011 Jul 18;63(8):640-58. doi: 10.1016/j.addr.2011.04.002. Review.

PMID: 21514334

 

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

Ngu K, Weinstein DS, Liu W, Langevine C, Combs DW, Zhuang S, Chen X, Madsen CS, Harper TW, Ahmad S, Robl JA.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4141-5. doi: 10.1016/j.bmcl.2011.05.107.

PMID: 21696952

 

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

Wang H, Robl JA, Hamann LG, Simpkins L, Golla R, Li YX, Seethala R, Zvyaga T, Gordon DA, Li JJ.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4146-9. doi: 10.1016/j.bmcl.2011.05.101.

PMID: 21689935

 

A rugged and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of BMS-790052 in plasma.

Jiang H, Zeng J, Deng Y, Xia YQ, Ouyang Z, Jemal M, Salcedo TW, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jul 15;879(22):2064-72. doi: 10.1016/j.jchromb.2011.05.036.

PMID: 21704571

 

Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.

Kish K, McDonnell PA, Goldfarb V, Gao M, Metzler WJ, Langley DR, Bryson JW, Kiefer SE, Carpenter B, Kostich WA, Westphal RS, Sheriff S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):768-74. doi: 10.1107/S1744309111017209.

PMID: 21795790

 

Impact of the implementation of a well-designed electronic laboratory notebook on bioanalytical laboratory function.

Zeng J, Hillman M, Arnold M.

Bioanalysis. 2011 Jul;3(13):1501-11. doi: 10.4155/bio.11.116. Review.

PMID: 21728774

 

Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells.

Qian Y, Khattak SF, Xing Z, He A, Kayne PS, Qian NX, Pan SH, Li ZJ.

Biotechnol Prog. 2011 Jul;27(4):1190-4. doi: 10.1002/btpr.630.

PMID: 21595052

 

Effect of rifampicin on the pharmacokinetics and pharmacodynamics of saxagliptin, a dipeptidyl peptidase-4 inhibitor, in healthy subjects.

Upreti VV, Boulton DW, Li L, Ching A, Su H, Lacreta FP, Patel CG.

Br J Clin Pharmacol. 2011 Jul;72(1):92-102. doi: 10.1111/j.1365-2125.2011.03937.x.

PMID: 21651615

 

Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects.

Patel CG, Kornhauser D, Vachharajani N, Komoroski B, Brenner E, Handschuh del Corral M, Li L, Boulton DW.

Diabetes Obes Metab. 2011 Jul;13(7):604-14. doi: 10.1111/j.1463-1326.2011.01381.x.

PMID: 21332626

 

To measure is to know: an approach to CADD performance metrics.

Loughney D, Claus BL, Johnson SR.

Drug Discov Today. 2011 Jul;16(13-14):548-54. doi: 10.1016/j.drudis.2011.05.003.

PMID: 21605697

 

Theory-guided efficient strategy to maximize speed and resolution in rapid gradient LC-MS/MS bioanalysis.

Wang J, Jia J, Aubry A, Arnold M, Jemal M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jul 1;879(21):1917-26. doi: 10.1016/j.jchromb.2011.05.019.

PMID: 21664884

 

Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds.

Fancher RM, Zhang H, Sleczka B, Derbin G, Rockar R, Marathe P.

J Pharm Sci. 2011 Jul;100(7):2979-88. doi: 10.1002/jps.22486.

PMID: 21254068

 

Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052.

Fridell RA, Qiu D, Valera L, Wang C, Rose RE, Gao M.

J Virol. 2011 Jul;85(14):7312-20. doi: 10.1128/JVI.00253-11.

PMID: 21593143

 

 

Efficacy and safety of saxagliptin combination therapy in US patients with type 2 diabetes.

Karyekar C, Donovan M, Allen E, Fleming D, Ravichandran S, Chen R.

Postgrad Med. 2011 Jul;123(4):63-70. doi: 10.3810/pgm.2011.07.2305.

PMID: 21680990

 

A real-world data analysis of dose effect of second-generation antipsychotic therapy on hemoglobin A1C level.

Guo Z, L'italien GJ, Jing Y, Baker RA, Forbes RA, Hebden T, Kim E.

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jul 1;35(5):1326-32. doi: 10.1016/j.pnpbp.2011.03.020.

PMID: 21515328

 

Case studies with new excipients: development, implementation and regulatory approval.

Koo OM, Varia SA.

Ther Deliv. 2011 Jul;2(7):949-56. Review.

PMID: 22833905

 

How to improve the clinical development paradigm and its division into phases I, II and III.

Bamberger M, Moore N, Lechat P; participants of Round Table N° 3 of Giens XXVI..

Therapie. 2011 Jul-Aug;66(4):331-4, 327-30. English, French.

PMID: 21851796

 

Comment faire évoluer le paradigme du développement clinique et son découpage en phases I, II, III.

Bamberger M, Moore N, Lechat P; participants à la Table Ronde N◦ 3 de Giens XXVI..

Therapie. 2011 Jul-Aug;66(4):327-30. doi: 10.2515/therapie/2011043. French. No abstract available.

PMID: 27392459

 

Transcriptional profiling of liver and effect of glucocorticoids in a rat adjuvant-induced arthritis model.

Song YL, Foster WR, Shuster DJ, Nadler SG, Salter-Cid L, Sasseville VG.

Vet Pathol. 2011 Jul;48(4):885-95. doi: 10.1177/0300985810390018.

PMID: 21149847

 

Overview of strategies for addressing BRIs in drug discovery: Impact on optimization and design.

Humphreys WG.

Chem Biol Interact. 2011 Jun 30;192(1-2):56-9. doi: 10.1016/j.cbi.2011.01.005. Review.

PMID: 21238435

 

Ipilimumab plus dacarbazine for previously untreated metastatic melanoma.

Robert C, Thomas L, Bondarenko I, O'Day S, Weber J, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, Davidson N, Richards J, Maio M, Hauschild A, Miller WH Jr, Gascon P, Lotem M, Harmankaya K, Ibrahim R, Francis S, Chen TT, Humphrey R, Hoos A, Wolchok JD.

N Engl J Med. 2011 Jun 30;364(26):2517-26. doi: 10.1056/NEJMoa1104621.

PMID: 21639810

 

The use of atomic spectroscopy in the pharmaceutical industry for the determination of trace elements in pharmaceuticals.

Lewen N.

J Pharm Biomed Anal. 2011 Jun 25;55(4):653-61. doi: 10.1016/j.jpba.2010.11.030. Review.

PMID: 21159460

 

A stepwise strategy employing automated screening and DryLab modeling for the development of robust methods for challenging high performance liquid chromatography separations: a case study.

Jayaraman K, Alexander AJ, Hu Y, Tomasella FP.

Anal Chim Acta. 2011 Jun 24;696(1-2):116-24. doi: 10.1016/j.aca.2011.04.010.

PMID: 21621040

 

Comparison of near infrared and microwave resonance sensors for at-line moisture determination in powders and tablets.

Corredor CC, Bu D, Both D.

Anal Chim Acta. 2011 Jun 24;696(1-2):84-93. doi: 10.1016/j.aca.2011.03.048.

PMID: 21621036

 

Estimation of the extent of in vivo formation of a mutagenic aromatic amine from a potent thyromimetic compound: correlation of in vitro and in vivo findings.

Behnia K, Cornelius G, Wang J, Shipkova P, Johnghar S, Washburn W, Brigance R, Stetsko P, Henwood A, Wojciechowski JP, Marathe P, Rodrigues AD, Humphreys WG.

Chem Res Toxicol. 2011 Jun 20;24(6):905-12. doi: 10.1021/tx200087q.

PMID: 21574629

 

Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families.

Wong TW, Lee FY, Emanuel S, Fairchild C, Fargnoli J, Fink B, Gavai A, Hammell A, Henley B, Hilt C, Hunt JT, Krishnan B, Kukral D, Lewin A, Malone H, Norris D, Oppenheimer S, Vite G, Yu C.

Clin Cancer Res. 2011 Jun 15;17(12):4031-41. doi: 10.1158/1078-0432.CCR-10-3417.

PMID: 21531814

 

Investigation into stability of poly(vinyl alcohol)-based Opadry® II films.

Koo OM, Fiske JD, Yang H, Nikfar F, Thakur A, Scheer B, Adams ML.

AAPS PharmSciTech. 2011 Jun;12(2):746-54. doi: 10.1208/s12249-011-9630-1.

PMID: 21647800

 

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors.

Sack JS, Thieffine S, Bandiera T, Fasolini M, Duke GJ, Jayaraman L, Kish KF, Klei HE, Purandare AV, Rosettani P, Troiani S, Xie D, Bertrand JA.

Biochem J. 2011 Jun 1;436(2):331-9. doi: 10.1042/BJ20102161.

PMID: 21410432

 

Common infections in the lung transplant recipient.

Sims KD, Blumberg EA.

Clin Chest Med. 2011 Jun;32(2):327-41. doi: 10.1016/j.ccm.2011.02.010. Review.

PMID: 21511093

 

Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks.

Pfützner A, Paz-Pacheco E, Allen E, Frederich R, Chen R; CV181039 Investigators..

Diabetes Obes Metab. 2011 Jun;13(6):567-76. doi: 10.1111/j.1463-1326.2011.01385.x.

PMID: 21342412

 

A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors.

Appiah KK, Kostich WA, Gerritz SW, Huang Y, Hamman BD, Allen J, Zhang W, Lanthorn TH, Albright CF, Westphal R, Banks MN, O'Connell JC.

J Biomol Screen. 2011 Jun;16(5):476-85. doi: 10.1177/1087057111399336.

PMID: 21406618

 

Aripiprazole in the treatment of irritability in pediatric patients (aged 6-17 years) with autistic disorder: results from a 52-week, open-label study.

Marcus RN, Owen R, Manos G, Mankoski R, Kamen L, McQuade RD, Carson WH, Corey-Lisle PK, Aman MG.

J Child Adolesc Psychopharmacol. 2011 Jun;21(3):229-36. doi: 10.1089/cap.2009.0121.

PMID: 21663425

 

Evaluation of a new preparative supercritical fluid chromatography system for compound library purification: the TharSFC SFC-MS Prep-100 system.

Ebinger K, Weller HN, Kiplinger J, Lefebvre P.

J Lab Autom. 2011 Jun;16(3):241-9. doi: 10.1016/j.jala.2010.03.005.

PMID: 21609708

 

It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS.

Ramanathan R, Jemal M, Ramagiri S, Xia YQ, Humpreys WG, Olah T, Korfmacher WA.

J Mass Spectrom. 2011 Jun;46(6):595-601. doi: 10.1002/jms.1921.

PMID: 21630388

 

Health care costs associated with treatment modification in type 2 diabetes mellitus patients taking oral anti-diabetic drugs.

Nrishnarajah G, Bhosle M, Chapman R.

Manag Care. 2011 Jun;20(6):42-8.

PMID: 21739924

 

Bleeding response induced by anti-thrombotic doses of a phosphoinositide 3-kinase (PI3K)-β inhibitor in mice.

Bird JE, Smith PL, Bostwick JS, Shipkova P, Schumacher WA.

Thromb Res. 2011 Jun;127(6):560-4. doi: 10.1016/j.thromres.2011.02.007.

PMID: 21396684

 

Effect of interferon-α2b on the expression of various drug-metabolizing enzymes and transporters in co-cultures of freshly prepared human primary hepatocytes.

Chen C, Han YH, Yang Z, Rodrigues AD.

Xenobiotica. 2011 Jun;41(6):476-85. doi: 10.3109/00498254.2011.560971.

PMID: 21381897

 

Bioactivation of substituted thiophenes including α-chlorothiophene-containing compounds in human liver microsomes.

Chen W, Caceres-Cortes J, Zhang H, Zhang D, Humphreys WG, Gan J.

Chem Res Toxicol. 2011 May 16;24(5):663-9. doi: 10.1021/tx100386z.

PMID: 21417487

 

The synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid hepatitis C virus polymerase NS5B inhibitors.

Martin SW, Glunz P, Beno BR, Bergstrom C, Romine JL, Priestley ES, Newman M, Gao M, Roberts S, Rigat K, Fridell R, Qiu D, Knobloh G, Wang YK.

Bioorg Med Chem Lett. 2011 May 15;21(10):2869-72. doi: 10.1016/j.bmcl.2011.03.086.

PMID: 21507645

 

Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.

Zheng X, Hudyma TW, Martin SW, Bergstrom C, Ding M, He F, Romine J, Poss MA, Kadow JF, Chang CH, Wan J, Witmer MR, Morin P, Camac DM, Sheriff S, Beno BR, Rigat KL, Wang YK, Fridell R, Lemm J, Qiu D, Liu M, Voss S, Pelosi L, Roberts SB, Gao M, Knipe J, Gentles RG.

Bioorg Med Chem Lett. 2011 May 15;21(10):2925-9. doi: 10.1016/j.bmcl.2011.03.067.

PMID: 21486696

 

SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.

Gentles RG, Ding M, Zheng X, Chupak L, Poss MA, Beno BR, Pelosi L, Liu M, Lemm J, Wang YK, Roberts S, Gao M, Kadow J.

Bioorg Med Chem Lett. 2011 May 15;21(10):3142-7. doi: 10.1016/j.bmcl.2011.03.008.

PMID: 21450465

 

Internal standard tracked dilution to overcome challenges in dried blood spots and robotic sample preparation for liquid chromatography/tandem mass spectrometry assays.

Liu G, Snapp HM, Ji QC.

Rapid Commun Mass Spectrom. 2011 May 15;25(9):1250-6. doi: 10.1002/rcm.4990.

PMID: 21488123

 

Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen.

Wagner AD, Kolb JM, Ozbal CC, Herbst JJ, Olah TV, Weller HN, Zvyaga TA, Shou WZ.

Rapid Commun Mass Spectrom. 2011 May 15;25(9):1231-40. doi: 10.1002/rcm.4984.

PMID: 21488121

 

Enzymatic preparation of 5-hydroxy-L-proline, N-Cbz-5-hydroxy-L-proline, and N-Boc-5-hydroxy-L-proline from (α-N-protected)-L-ornithine using a transaminase or an amine oxidase.

Hanson RL, Johnston RM, Goldberg SL, Parker WL, Patel RN.

Enzyme Microb Technol. 2011 May 6;48(6-7):445-53. doi: 10.1016/j.enzmictec.2011.03.007.

PMID: 22113015

 

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe.

Abu-Absi NR, Kenty BM, Cuellar ME, Borys MC, Sakhamuri S, Strachan DJ, Hausladen MC, Li ZJ.

Biotechnol Bioeng. 2011 May;108(5):1215-21. doi: 10.1002/bit.23023.

PMID: 21449033

 

Pooled model-based approach to compare the pharmacokinetics of entecavir between Japanese and non-Japanese chronic hepatitis B patients.

Yoshitsugu H, Sakurai T, Ishikawa H, Roy A, Bifano M, Pfister M, Seriu T, Hiraoka M.

Diagn Microbiol Infect Dis. 2011 May;70(1):91-100. doi: 10.1016/j.diagmicrobio.2010.12.009.

PMID: 21513847

 

Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans.

Gong J, Gan J, Caceres-Cortes J, Christopher LJ, Arora V, Masson E, Williams D, Pursley J, Allentoff A, Lago M, Tran SB, Iyer RA.

Drug Metab Dispos. 2011 May;39(5):891-903. doi: 10.1124/dmd.110.037341.

PMID: 21289073

 

Fatty acid and water-soluble polymer-based controlled release drug delivery system.

Desai D, Kothari S, Chen W, Wang J, Huang M, Sharma L.

J Pharm Sci. 2011 May;100(5):1900-12. doi: 10.1002/jps.22397.

PMID: 21374622

 

Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2).

Shen H, Lee FY, Gan J.

J Pharmacol Exp Ther. 2011 May;337(2):423-32. doi: 10.1124/jpet.110.175604.

PMID: 21262849

 

Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor.

Wong PC, Pinto DJ, Zhang D.

J Thromb Thrombolysis. 2011 May;31(4):478-92. doi: 10.1007/s11239-011-0551-3. Review.

PMID: 21318583

 

Large sample inference for an assay quality measure used in high-throughput screening.

Majumdar A, Stock D.

Pharm Stat. 2011 May-Jun;10(3):227-31. doi: 10.1002/pst.452. No abstract available.

PMID: 20931668

 

Synopsis of some recent tactical application of bioisosteres in drug design.

Meanwell NA.

J Med Chem. 2011 Apr 28;54(8):2529-91. doi: 10.1021/jm1013693. No abstract available.

PMID: 21413808

 

Metabolomic and transcriptomic changes induced by overnight (16 h) fasting in male and female Sprague-Dawley rats.

Robertson DG, Ruepp SU, Stryker SA, Hnatyshyn SY, Shipkova PA, Aranibar N, Mcnaney CA, Fiehn O, Reily MD.

Chem Res Toxicol. 2011 Apr 18;24(4):481-7. doi: 10.1021/tx200074f.

PMID: 21381695

 

Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.

Gentles RG, Sheriff S, Beno BR, Wan C, Kish K, Ding M, Zheng X, Chupak L, Poss MA, Witmer MR, Morin P, Wang YK, Rigat K, Lemm J, Voss S, Liu M, Pelosi L, Roberts SB, Gao M, Kadow JF.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2212-5. doi: 10.1016/j.bmcl.2011.03.011. Erratum in: Bioorg Med Chem Lett. 2011 Sep 15;21(18):5650-1.

PMID: 21441029

 

Potential CRF1R PET imaging agents: N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines.

Zuev D, Mattson RJ, Huang H, Mattson GK, Zueva L, Nielsen JM, Kozlowski ES, Huang XS, Wu D, Gao Q, Lodge NJ, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2484-8. doi: 10.1016/j.bmcl.2011.02.050.

PMID: 21411322

 

Development and evaluation of a multiple-plate fraction collector for sample processing: application to radioprofiling in drug metabolism studies.

Barros A Jr, Ly VT, Chando TJ, Ruan Q, Donenfeld SL, Holub DP, Christopher LJ.

J Pharm Biomed Anal. 2011 Apr 5;54(5):979-86. doi: 10.1016/j.jpba.2010.11.029.

PMID: 21168298

 

Optimization of Exactive Orbitrap™ acquisition parameters for quantitative bioanalysis.

Wong RL, Xin B, Olah T.

Bioanalysis. 2011 Apr;3(8):863-71. doi: 10.4155/bio.11.37.

PMID: 21510760

 

Influence of renal or hepatic impairment on the pharmacokinetics of saxagliptin.

Boulton DW, Li L, Frevert EU, Tang A, Castaneda L, Vachharajani NN, Kornhauser DM, Patel CG.

Clin Pharmacokinet. 2011 Apr;50(4):253-65. doi: 10.2165/11584350-000000000-00000.

PMID: 21348538

 

Inhibition of SGLT2: a novel strategy for treatment of type 2 diabetes mellitus.

Pfister M, Whaley JM, Zhang L, List JF.

Clin Pharmacol Ther. 2011 Apr;89(4):621-5. doi: 10.1038/clpt.2011.16. Review. No abstract available.

PMID: 21346749

 

Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium-glucose co-transporter type 2, in Japanese subjects without and with type 2 diabetes mellitus.

Kasichayanula S, Chang M, Hasegawa M, Liu X, Yamahira N, LaCreta FP, Imai Y, Boulton DW.

Diabetes Obes Metab. 2011 Apr;13(4):357-65. doi: 10.1111/j.1463-1326.2011.01359.x.

PMID: 21226818

 

NMR-based metabolomics of mammalian cell and tissue cultures.

Aranibar N, Borys M, Mackin NA, Ly V, Abu-Absi N, Abu-Absi S, Niemitz M, Schilling B, Li ZJ, Brock B, Russell RJ 2nd, Tymiak A, Reily MD.

J Biomol NMR. 2011 Apr;49(3-4):195-206. doi: 10.1007/s10858-011-9490-8.

PMID: 21373840

 

Scale considerations for selection of saccharide excipients for liquid formulations.

Zhou R, Schlam RF, Yin S, Gandhi RB, Adams ML.

J Pharm Sci. 2011 Apr;100(4):1605-6. doi: 10.1002/jps.22378. No abstract available.

PMID: 24081479

 

Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid and xenobiotic X receptor humanized mice.

Raybon JJ, Pray D, Morgan DG, Zoeckler M, Zheng M, Sinz M, Kim S.

J Pharmacol Exp Ther. 2011 Apr;337(1):75-82. doi: 10.1124/jpet.110.176677.

PMID: 21205914

 

Transformation of anionically activated trifluoromethyl groups to heterocycles under mild aqueous conditions.

Qiao JX, Wang TC, Hu C, Li J, Wexler RR, Lam PY.

Org Lett. 2011 Apr 1;13(7):1804-7. doi: 10.1021/ol200326u.

PMID: 21381681

 

Good documentation practice in clinical research.

Bargaje C.

Perspect Clin Res. 2011 Apr;2(2):59-63. doi: 10.4103/2229-3485.80368.

PMID: 21731856

 

Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.

Foster WR, Car BD, Shi H, Levesque PC, Obermeier MT, Gan J, Arezzo JC, Powlin SS, Dinchuk JE, Balog A, Salvati ME, Attar RM, Gottardis MM.

Prostate. 2011 Apr;71(5):480-8. doi: 10.1002/pros.21263.

PMID: 20878947

 

JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.

Galici R, Rezvani AH, Aluisio L, Lord B, Levin ED, Fraser I, Boggs J, Welty N, Shoblock JR, Motley ST, Letavic MA, Carruthers NI, Dugovic C, Lovenberg TW, Bonaventure P.

Psychopharmacology (Berl). 2011 Apr;214(4):829-41. doi: 10.1007/s00213-010-2092-4.

PMID: 21086115

 

Metabolism of [2-14C]p-hydroxyphenyl acetic acid in rat, monkey and human hepatocytes and in bile-duct cannulated rats.

Zhou L, Liu-Kreyche P, Iyer RA.

Xenobiotica. 2011 Apr;41(4):312-9. doi: 10.3109/00498254.2010.540681.

PMID: 21143006

 

Strategies for the identification of allosteric modulators of G-protein-coupled receptors.

Burford NT, Watson J, Bertekap R, Alt A.

Biochem Pharmacol. 2011 Mar 15;81(6):691-702. doi: 10.1016/j.bcp.2010.12.012. Review.

PMID: 21184747

 

Apixaban in patients with atrial fibrillation.

Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S, Flaker G, Avezum A, Hohnloser SH, Diaz R, Talajic M, Zhu J, Pais P, Budaj A, Parkhomenko A, Jansky P, Commerford P, Tan RS, Sim KH, Lewis BS, Van Mieghem W, Lip GY, Kim JH, Lanas-Zanetti F, Gonzalez-Hermosillo A, Dans AL, Munawar M, O'Donnell M, Lawrence J, Lewis G, Afzal R, Yusuf S; AVERROES Steering Committee and Investigators..

N Engl J Med. 2011 Mar 3;364(9):806-17. doi: 10.1056/NEJMoa1007432.

PMID: 21309657

 

Advances in mass spectrometry applied to pharmaceutical metabolomics.

Drexler DM, Reily MD, Shipkova PA.

Anal Bioanal Chem. 2011 Mar;399(8):2645-53. doi: 10.1007/s00216-010-4370-8. Review.

PMID: 21107980

 

Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling.

Aranibar N, Vassallo JD, Rathmacher J, Stryker S, Zhang Y, Dai J, Janovitz EB, Robertson D, Reily M, Lowe-Krentz L, Lehman-McKeeman L.

Anal Biochem. 2011 Mar 1;410(1):84-91. doi: 10.1016/j.ab.2010.11.023.

PMID: 21094120

 

Biotherapeutic bioanalysis: a multi-indication case study review.

Myler HA, Given A, Kolz K, Mora JR, Hristopoulos G.

Bioanalysis. 2011 Mar;3(6):623-43. doi: 10.4155/bio.11.33. Review.

PMID: 21417732

 

Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3.

Harikrishnan LS, Kamau MG, Wan H, Inghrim JA, Zimmermann K, Sang X, Mastalerz HA, Johnson WL, Zhang G, Lombardo LJ, Poss MA, Trainor GL, Tokarski JS, Lorenzi MV, You D, Gottardis MM, Baldwin KF, Lippy J, Nirschl DS, Qiu R, Miller AV, Khan J, Sack JS, Purandare AV.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1425-8. doi: 10.1016/j.bmcl.2011.01.022.

PMID: 21282055

 

Demonstrating β-glucan and yeast peptide clearance in biopharmaceutical downstream processes.

Jiang C, Scherfner S, Dick LW Jr, Mahon D, Qiu D, Cheng KC, Shukla AA.

Biotechnol Prog. 2011 Mar-Apr;27(2):442-50. doi: 10.1002/btpr.568. Erratum in: Biotechnol Prog. 2011 Jul-Aug;27(4):1195. Dick, Lawrence W Jr [added]; Mahon, David [added]; Qiu, Difei [added]; Cheng, Kuang-Chuan [added].

PMID: 21365784

 

Efficacy of aripiprazole adjunctive to lithium or valproate in the long-term treatment of patients with bipolar I disorder with an inadequate response to lithium or valproate monotherapy: a multicenter, double-blind, randomized study.

Marcus R, Khan A, Rollin L, Morris B, Timko K, Carson W, Sanchez R.

Bipolar Disord. 2011 Mar;13(2):133-44. doi: 10.1111/j.1399-5618.2011.00898.x.

PMID: 21443567

 

Factors associated with complete adherence to HIV combination antiretroviral therapy.

Juday T, Gupta S, Grimm K, Wagner S, Kim E.

HIV Clin Trials. 2011 Mar-Apr;12(2):71-8. doi: 10.1310/hct1202-71.

PMID: 21498150

 

Effect of low-dose omeprazole (20 mg daily) on the pharmacokinetics of multiple-dose atazanavir with ritonavir in healthy subjects.

Zhu L, Persson A, Mahnke L, Eley T, Li T, Xu X, Agarwala S, Dragone J, Bertz R.

J Clin Pharmacol. 2011 Mar;51(3):368-77. doi: 10.1177/0091270010367651.

PMID: 20457590

 

Adherence to chronic hepatitis B treatment guideline recommendations for laboratory monitoring of patients who are not receiving antiviral treatment.

Juday T, Tang H, Harris M, Powers AZ, Kim E, Hanna GJ.

J Gen Intern Med. 2011 Mar;26(3):239-44. doi: 10.1007/s11606-010-1549-9.

PMID: 20978862

 

Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs.

Drexler DM, Tannehill-Gregg SH, Wang L, Brock BJ.

J Pharmacol Toxicol Methods. 2011 Mar-Apr;63(2):205-8. doi: 10.1016/j.vascn.2010.10.003.

PMID: 21040797

 

Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans.

List JF, Whaley JM.

Kidney Int Suppl. 2011 Mar;(120):S20-7. doi: 10.1038/ki.2010.512. Review.

PMID: 21358698

 

Mapping progress in toxicology research by the content of the best papers published in Society of Toxicology Journals: a synopsis of the best paper awardees (1974-2011).

Lehman-McKeeman LD.

Toxicol Sci. 2011 Mar;120 Suppl 1:S1-7. doi: 10.1093/toxsci/kfq369. No abstract available.

PMID: 21342918

 

Metabolomics in toxicology: preclinical and clinical applications.

Robertson DG, Watkins PB, Reily MD.

Toxicol Sci. 2011 Mar;120 Suppl 1:S146-70. doi: 10.1093/toxsci/kfq358. Review. No abstract available.

PMID: 21127352

 

Improvements in participation in usual daily activities in patients with rheumatoid arthritis treated with abatacept.

Li T, Wells G, Westhovens R, Emery P, Becker JC, Tugwell P.

Value Health. 2011 Mar-Apr;14(2):361-70. doi: 10.1016/j.jval.2010.10.008.

PMID: 21296603

 

Chiral separation of potent corticotropin-releasing factor-1 receptor antagonists by supercritical fluid chromatography.

Qian-Cutrone J, Hartz R, Ahuja VT, Vrudhula VM, Wu DR, Dalterio RA, Wang-Iverson D, Bronson JJ.

J Pharm Biomed Anal. 2011 Feb 20;54(3):602-6. doi: 10.1016/j.jpba.2010.09.031.

PMID: 21036503

 

Antiviral activity, pharmacokinetics, and safety of BMS-488043, a novel oral small-molecule HIV-1 attachment inhibitor, in HIV-1-infected subjects.

Hanna GJ, Lalezari J, Hellinger JA, Wohl DA, Nettles R, Persson A, Krystal M, Lin P, Colonno R, Grasela DM.

Antimicrob Agents Chemother. 2011 Feb;55(2):722-8. doi: 10.1128/AAC.00759-10.

PMID: 21078951

 

In vivo patterns of resistance to the HIV attachment inhibitor BMS-488043.

Zhou N, Nowicka-Sans B, Zhang S, Fan L, Fang J, Fang H, Gong YF, Eggers B, Langley DR, Wang T, Kadow J, Grasela D, Hanna GJ, Alexander L, Colonno R, Krystal M, Lin PF.

Antimicrob Agents Chemother. 2011 Feb;55(2):729-37. doi: 10.1128/AAC.01173-10.

PMID: 21078948

 

Implications of differences in bioanalytical regulations between Canada, USA and South America.

Arnold ME.

Bioanalysis. 2011 Feb;3(3):253-8. doi: 10.4155/bio.10.187.

PMID: 21320043

 

Tissue distribution and elimination of [14C]apixaban in rats.

Wang L, He K, Maxwell B, Grossman SJ, Tremaine LM, Humphreys WG, Zhang D.

Drug Metab Dispos. 2011 Feb;39(2):256-64. doi: 10.1124/dmd.110.036442.

PMID: 21071521

 

Metabolism and disposition of 14C-labeled peliglitazar in humans.

Wang L, Munsick C, Chen S, Bonacorsi S, Cheng PT, Humphreys WG, Zhang D.

Drug Metab Dispos. 2011 Feb;39(2):228-38. doi: 10.1124/dmd.110.035089.

PMID: 20978103

 

A review of electronic laboratory notebooks available in the market today.

Rubacha M, Rattan AK, Hosselet SC.

J Lab Autom. 2011 Feb;16(1):90-8. doi: 10.1016/j.jala.2009.01.002.

PMID: 21609689

 

Hazard identification of strong dermal sensitizers.

Gould JC, Taylor S.

Toxicol Mech Methods. 2011 Feb;21(2):86-92. doi: 10.3109/15376516.2010.484622.

PMID: 20500014

 

Urinary metabolites of 2-bromoethanamine identified by stable isotope labelling: evidence for carbamoylation and glutathione conjugation.

Shipkova P, Vassallo JD, Aranibar N, Hnatyshyn S, Zhang H, Clayton TA, Cantor GH, Sanders M, Coen M, Lindon JC, Holmes E, Nicholson JK, Lehman-McKeeman L.

Xenobiotica. 2011 Feb;41(2):144-54. doi: 10.3109/00498254.2010.529179.

PMID: 21043805

 

A strategy for liquid chromatography/tandem mass spectrometry based quantitation of pegylated protein drugs in plasma using plasma protein precipitation with water-miscible organic solvents and subsequent trypsin digestion to generate surrogate peptides for detection.

Wu ST, Ouyang Z, Olah TV, Jemal M.

Rapid Commun Mass Spectrom. 2011 Jan 30;25(2):281-90. doi: 10.1002/rcm.4856.

PMID: 21192023

 

Cannabinoid CB(1) receptor ligand binding and function examined through mutagenesis studies of F200 and S383.

Sitkoff DF, Lee N, Ellsworth BA, Huang Q, Kang L, Baska R, Huang Y, Sun C, Pendri A, Malley MF, Scaringe RP, Gougoutas JZ, Reggio PH, Ewing WR, Pelleymounter MA, Carlson KE.

Eur J Pharmacol. 2011 Jan 25;651(1-3):9-17. doi: 10.1016/j.ejphar.2010.10.056.

PMID: 21044623

 

Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Fink BE, Norris D, Mastalerz H, Chen P, Goyal B, Zhao Y, Kim SH, Vite GD, Lee FY, Zhang H, Oppenheimer S, Tokarski JS, Wong TW, Gavai AV.

Bioorg Med Chem Lett. 2011 Jan 15;21(2):781-5. doi: 10.1016/j.bmcl.2010.11.100.

PMID: 21177105

 

Mechanistic studies on a P450-mediated rearrangement of BMS-690514: conversion of a pyrrolotriazine to a hydroxypyridotriazine.

Hong H, Caceres-Cortes J, Su H, Huang X, Roongta V, Bonacorsi S Jr, Hong Y, Tian Y, Iyer RA, Humphreys WG, Christopher LJ.

Chem Res Toxicol. 2011 Jan 14;24(1):125-34. doi: 10.1021/tx100337s.

PMID: 21080678

 

Trends in kinase selectivity: insights for target class-focused library screening.

Posy SL, Hermsmeier MA, Vaccaro W, Ott KH, Todderud G, Lippy JS, Trainor GL, Loughney DA, Johnson SR.

J Med Chem. 2011 Jan 13;54(1):54-66. doi: 10.1021/jm101195a.

PMID: 21128601

 

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes.

Romine JL, St Laurent DR, Leet JE, Martin SW, Serrano-Wu MH, Yang F, Gao M, O'Boyle DR 2nd, Lemm JA, Sun JH, Nower PT, Huang XS, Deshpande MS, Meanwell NA, Snyder LB.

ACS Med Chem Lett. 2011 Jan 11;2(3):224-9. doi: 10.1021/ml1002647.

PMID: 24900306

 

One-year risk of psychiatric hospitalization and associated treatment costs in bipolar disorder treated with atypical antipsychotics: a retrospective claims database analysis.

Kim E, You M, Pikalov A, Van-Tran Q, Jing Y.

BMC Psychiatry. 2011 Jan 7;11:6. doi: 10.1186/1471-244X-11-6.

PMID: 21214937

 

FDR-FET: an optimizing gene set enrichment analysis method.

Ji RR, Ott KH, Yordanova R, Bruccoleri RE.

Adv Appl Bioinform Chem. 2011;4:37-42. doi: 10.2147/AABC.S15840.

PMID: 21918636

 

Development of a chimeric replicon system for phenotypic analysis of NS3 protease sequences from HCV clinical isolates.

Sheaffer AK, Lee MS, Hernandez D, Chaniewski S, Yu F, Falk P, Friborg J, Zhai G, McPhee F.

Antivir Ther. 2011;16(5):705-18. doi: 10.3851/IMP1825.

PMID: 21817192

 

The effect of atazanavir/ritonavir on the pharmacokinetics of an oral contraceptive containing ethinyl estradiol and norgestimate in healthy women.

Zhang J, Chung E, Yones C, Persson A, Mahnke L, Eley T, Xu X, Bertz R.

Antivir Ther. 2011;16(2):157-64. doi: 10.3851/IMP1724.

PMID: 21447864

 

The effect of efavirenz on the pharmacokinetics of an oral contraceptive containing ethinyl estradiol and norgestimate in healthy HIV-negative women.

Sevinsky H, Eley T, Persson A, Garner D, Yones C, Nettles R, Krantz K, Bertz R, Zhang J.

Antivir Ther. 2011;16(2):149-56. doi: 10.3851/IMP1725.

PMID: 21447863

 

Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.

Dyckman AJ, Langevine CM, Quesnelle C, Kempson J, Guo J, Gill P, Spergel SH, Watterson SH, Li T, Nirschl DS, Gillooly KM, Pattoli MA, McIntyre KW, Chen L, McKinnon M, Dodd JH, Barrish JC, Burke JR, Pitts WJ.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6. doi: 10.1016/j.bmcl.2010.10.133.

PMID: 21087862

 

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.

Marcin LR, Higgins MA, Zusi FC, Zhang Y, Dee MF, Parker MF, Muckelbauer JK, Camac DM, Morin PE, Ramamurthy V, Tebben AJ, Lentz KA, Grace JE, Marcinkeviciene JA, Kopcho LM, Burton CR, Barten DM, Toyn JH, Meredith JE, Albright CF, Bronson JJ, Macor JE, Thompson LA.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):537-41. doi: 10.1016/j.bmcl.2010.10.079.

PMID: 21078556

 

Bioequivalence of saxagliptin/metformin extended-release (XR) fixed-dose combination tablets and single-component saxagliptin and metformin XR tablets in healthy adult subjects.

Boulton DW, Smith CH, Li L, Huang J, Tang A, LaCreta FP.

Clin Drug Investig. 2011;31(9):619-30. doi: 10.2165/11590290-000000000-00000.

PMID: 21819160

 

Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole.

Patel CG, Li L, Girgis S, Kornhauser DM, Frevert EU, Boulton DW.

Clin Pharmacol. 2011;3:13-25. doi: 10.2147/CPAA.S15227.

PMID: 22287853

 

Impact of early intervention and disease modification in patients with predementia Alzheimer's disease: a Markov model simulation.

Budd D, Burns LC, Guo Z, L'italien G, Lapuerta P.

Clinicoecon Outcomes Res. 2011;3:189-95. doi: 10.2147/CEOR.S22265.

PMID: 22046104

 

Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjects.

Kasichayanula S, Liu X, Shyu WC, Zhang W, Pfister M, Griffen SC, Li T, LaCreta FP, Boulton DW.

Diabetes Obes Metab. 2011 Jan;13(1):47-54. doi: 10.1111/j.1463-1326.2010.01314.x.

PMID: 21114603

 

Characterization of protein therapeutics by mass spectrometry: recent developments and future directions.

Chen G, Warrack BM, Goodenough AK, Wei H, Wang-Iverson DB, Tymiak AA.

Drug Discov Today. 2011 Jan;16(1-2):58-64. doi: 10.1016/j.drudis.2010.11.003. Review.

PMID: 21093608

 

Plasma stability-dependent circulation of acyl glucuronide metabolites in humans: how circulating metabolite profiles of muraglitazar and peliglitazar can lead to misleading risk assessment.

Zhang D, Raghavan N, Wang L, Xue Y, Obermeier M, Chen S, Tao S, Zhang H, Cheng PT, Li W, Ramanathan R, Yang Z, Humphreys WG.

Drug Metab Dispos. 2011 Jan;39(1):123-31. doi: 10.1124/dmd.110.035048.

PMID: 20876787

 

A comparison of approaches to control for confounding factors by regression models.

Xing G, Lin CY, Xing C.

Hum Hered. 2011;72(3):194-205. doi: 10.1159/000332743.

PMID: 22086357

 

Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.

Barten DM, Cadelina GW, Hoque N, DeCarr LB, Guss VL, Yang L, Sankaranarayanan S, Wes PD, Flynn ME, Meredith JE, Ahlijanian MK, Albright CF.

J Alzheimers Dis. 2011;24 Suppl 2:127-41. doi: 10.3233/JAD-2011-110161.

PMID: 21422517

 

A combined desorption ionization by charge exchange (DICE) and desorption electrospray ionization (DESI) source for mass spectrometry.

Chan CC, Bolgar MS, Miller SA, Attygalle AB.

J Am Soc Mass Spectrom. 2011 Jan;22(1):173-8. doi: 10.1007/s13361-010-0001-z.

PMID: 21472555

 

Comparison of second-generation antipsychotic treatment on psychiatric hospitalization in Medicaid beneficiaries with bipolar disorder.

Jing Y, Johnston SS, Fowler R, Bates JA, Forbes RA, Hebden T.

J Med Econ. 2011;14(6):777-86. doi: 10.3111/13696998.2011.625066.

PMID: 21954966

 

The effect of the physical states of binders on high-shear wet granulation and granule properties: a mechanistic approach towards understanding high-shear wet granulation process. Part I. Physical characterization of binders.

Li J, Tao L, Dali M, Buckley D, Gao J, Hubert M.

J Pharm Sci. 2011 Jan;100(1):164-73. doi: 10.1002/jps.22260.

PMID: 20575065

 

The effect of the physical states of binders on high-shear wet granulation and granule properties: a mechanistic approach toward understanding high-shear wet granulation process. Part II. Granulation and granule properties.

Li J, Tao L, Dali M, Buckley D, Gao J, Hubert M.

J Pharm Sci. 2011 Jan;100(1):294-310. doi: 10.1002/jps.22261.

PMID: 20575062

 

A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor.

Emanuel SL, Engle LJ, Chao G, Zhu RR, Cao C, Lin Z, Yamniuk AP, Hosbach J, Brown J, Fitzpatrick E, Gokemeijer J, Morin P, Morse BA, Carvajal IM, Fabrizio D, Wright MC, Das Gupta R, Gosselin M, Cataldo D, Ryseck RP, Doyle ML, Wong TW, Camphausen RT, Cload ST, Marsh HN, Gottardis MM, Furfine ES.

MAbs. 2011 Jan-Feb;3(1):38-48.

PMID: 21099371

 

Methods for combinatorial and parallel library design.

Schnur DM, Beno BR, Tebben AJ, Cavallaro C.

Methods Mol Biol. 2011;672:387-434. doi: 10.1007/978-1-60761-839-3_16.

PMID: 20838978

 

Beyond rhodopsin: G protein-coupled receptor structure and modeling incorporating the beta2-adrenergic and adenosine A(2A) crystal structures.

Tebben AJ, Schnur DM.

Methods Mol Biol. 2011;672:359-86. doi: 10.1007/978-1-60761-839-3_15. Review.

PMID: 20838977

 

Long-term safety and tolerability of open-label aripiprazole augmentation of antidepressant therapy in major depressive disorder.

Berman RM, Thase ME, Trivedi MH, Hazel JA, Marler SV, McQuade RD, Carson W, Baker RA, Marcus RN.

Neuropsychiatr Dis Treat. 2011;7:303-12. doi: 10.2147/NDT.S18333.

PMID: 21655344

 

 Performance of Cpred/Cobs concentration ratios as a metric reflecting adherence to antidepressant drug therapy.

Feng Y, Gastonguay MR, Pollock BG, Frank E, Kepple GH, Bies RR.

Neuropsychiatr Dis Treat. 2011;7:117-25. doi: 10.2147/NDT.S15921.

PMID: 21552314

 

Exome sequencing reveals comprehensive genomic alterations across eight cancer cell lines.

Chang H, Jackson DG, Kayne PS, Ross-Macdonald PB, Ryseck RP, Siemers NO.

PLoS One. 2011;6(6):e21097. doi: 10.1371/journal.pone.0021097.

PMID: 21701589

 

A 52-week, double-blind evaluation of the metabolic effects of aripiprazole and lithium in bipolar I disorder.

McIntyre RS, McElroy SL, Eudicone JM, Forbes RA, Carlson BX, Baker RA.

Prim Care Companion CNS Disord. 2011;13(6). pii: PCC.11m01182. doi: 10.4088/PCC.11m01182.

PMID: 22454801

 

 Adnectins: engineered target-binding protein therapeutics.

Lipovsek D.

Protein Eng Des Sel. 2011 Jan;24(1-2):3-9. doi: 10.1093/protein/gzq097. Review.

PMID: 21068165

 

 Synergistic activity of ixabepilone plus other anticancer agents: preclinical and clinical evidence.

Lee F, Jure-Kunkel MN, Salvati ME.

Ther Adv Med Oncol. 2011 Jan;3(1):11-25. doi: 10.1177/1758834010386402.

PMID: 21789152

 

 Quantifying the impact of nonadherence patterns on exposure to oral immunosuppressants.

Maclean JR, Pfister M, Zhou Z, Roy A, Tuomari VA, Heifets M.

Ther Clin Risk Manag. 2011;7:149-56. doi: 10.2147/TCRM.S16870.

PMID: 21691585

 

 Apixaban decreases coagulation activity in patients with acute deep-vein thrombosis.

Barrett YC, Wang J, Knabb R, Mohan P.

Thromb Haemost. 2011 Jan;105(1):181-9. doi: 10.1160/TH10-06-0393.

PMID: 20941459

Back to Top

2010 Publications

An integrated bioanalytical platform for supporting high-throughput serum protein binding screening.

Zhang J, Shou WZ, Vath M, Kieltyka K, Maloney J, Elvebak L, Stewart J, Herbst J, Weller HN.

Rapid Commun Mass Spectrom. 2010 Dec 30;24(24):3593-601. doi: 10.1002/rcm.4817.

PMID: 21080511

 

Apixaban versus enoxaparin for thromboprophylaxis after hip replacement.

Lassen MR, Gallus A, Raskob GE, Pineo G, Chen D, Ramirez LM; ADVANCE-3 Investigators..

N Engl J Med. 2010 Dec 23;363(26):2487-98. doi: 10.1056/NEJMoa1006885.

PMID: 21175312

 

 Defining process design space for a hydrophobic interaction chromatography (HIC) purification step: application of quality by design (QbD) principles.

Jiang C, Flansburg L, Ghose S, Jorjorian P, Shukla AA.

Biotechnol Bioeng. 2010 Dec 15;107(6):985-97. doi: 10.1002/bit.22894.

PMID: 20683852

 

Dimethyl-diphenyl-propanamide derivatives as nonsteroidal dissociated glucocorticoid receptor agonists.

Yang BV, Weinstein DS, Doweyko LM, Gong H, Vaccaro W, Huynh T, Xiao HY, Doweyko AM, McKay L, Holloway DA, Somerville JE, Habte S, Cunningham M, McMahon M, Townsend R, Shuster D, Dodd JH, Nadler SG, Barrish JC.

J Med Chem. 2010 Dec 9;53(23):8241-51. doi: 10.1021/jm100957a.

PMID: 21073190

 

Investigation into the degree of variability in the solid-state properties of common pharmaceutical excipients-anhydrous lactose.

Gamble JF, Chiu WS, Gray V, Toale H, Tobyn M, Wu Y.

AAPS PharmSciTech. 2010 Dec;11(4):1552-7. doi: 10.1208/s12249-010-9527-4.

PMID: 21049309

 

Identifying, evaluating, and controlling bioanalytical risks resulting from nonuniform matrix ion suppression/enhancement and nonlinear liquid chromatography-mass spectrometry assay response.

Liu G, Ji QC, Arnold ME.

Anal Chem. 2010 Dec 1;82(23):9671-7. doi: 10.1021/ac1013018.

PMID: 21038862

 

Validated LC-MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma.

Aubry AF, Gu H, Magnier R, Morgan L, Xu X, Tirmenstein M, Wang B, Deng Y, Cai J, Couerbe P, Arnold M.

Bioanalysis. 2010 Dec;2(12):2001-9. doi: 10.4155/bio.10.139.

PMID: 21110743

 

5-amino-pyrazoles as potent and selective p38α inhibitors.

Das J, Moquin RV, Dyckman AJ, Li T, Pitt S, Zhang R, Shen DR, McIntyre KW, Gillooly K, Doweyko AM, Newitt JA, Sack JS, Zhang H, Kiefer SE, Kish K, McKinnon M, Barrish JC, Dodd JH, Schieven GL, Leftheris K.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):6886-9. doi: 10.1016/j.bmcl.2010.10.034.

PMID: 21035336

 

A dysmorphology score system for assessing embryo abnormalities in rat whole embryo culture.

Zhang CX, Danberry T, Jacobs MA, Augustine-Rauch K.

Birth Defects Res B Dev Reprod Toxicol. 2010 Dec;89(6):485-92. doi: 10.1002/bdrb.20262.

PMID: 21058394

 

Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members.

Chen J, Williams S, Ho S, Loraine H, Hagan D, Whaley JM, Feder JN.

Diabetes Ther. 2010 Dec;1(2):57-92. doi: 10.1007/s13300-010-0006-4.

PMID: 22127746

 

Discovery and development of 5-HT(₂C) receptor agonists for obesity: is there light at the end of the tunnel?

Miller KJ, Wacker DA.

Future Med Chem. 2010 Dec;2(12):1761-75. doi: 10.4155/fmc.10.261.

PMID: 21428799

 

Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay.

Barrett YC, Wang Z, Frost C, Shenker A.

Thromb Haemost. 2010 Dec;104(6):1263-71. doi: 10.1160/TH10-05-0328.

PMID: 20978714

 

Metabolomics and mechanisms: sometimes the fisher catches a big fish.

Cantor GH.

Toxicol Sci. 2010 Dec;118(2):321-3. doi: 10.1093/toxsci/kfq297. No abstract available.

PMID: 20864629

 

Interview with Dr. Mark Cockett: current trends in screening for antiviral therapeutics. Interviewed by Nina N. Brahme and Devin J. Noblin.

Cockett M.

Yale J Biol Med. 2010 Dec;83(4):235-40.

PMID: 21165343

 

Effect of force feeder on tablet strength during compression.

Narang AS, Rao VM, Guo H, Lu J, Desai DS.

Int J Pharm. 2010 Nov 30;401(1-2):7-15. doi: 10.1016/j.ijpharm.2010.08.027.

PMID: 20816733

 

Effect of mobile phase pH, aqueous-organic ratio, and buffer concentration on electrospray ionization tandem mass spectrometric fragmentation patterns: implications in liquid chromatography/tandem mass spectrometric bioanalysis.

Wang J, Aubry A, Bolgar MS, Gu H, Olah TV, Arnold M, Jemal M.

Rapid Commun Mass Spectrom. 2010 Nov 30;24(22):3221-9. doi: 10.1002/rcm.4748.

PMID: 20972995

 

Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma.

Berman D, Parker SM, Siegel J, Chasalow SD, Weber J, Galbraith S, Targan SR, Wang HL.

Cancer Immun. 2010 Nov 24;10:11.

PMID: 21090563

 

Identifying and overcoming bioanalytical challenges associated with chlorine-containing dehydrogenation metabolites.

Furlong MT, Wujcik CE, Ji C, Su Y.

Rapid Commun Mass Spectrom. 2010 Nov 15;24(21):3092-102. doi: 10.1002/rcm.4741.

PMID: 20941755

 

Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors.

King HD, Meng Z, Deskus JA, Sloan CP, Gao Q, Beno BR, Kozlowski ES, Lapaglia MA, Mattson GK, Molski TF, Taber MT, Lodge NJ, Mattson RJ, Macor JE.

J Med Chem. 2010 Nov 11;53(21):7564-72. doi: 10.1021/jm100515z.

PMID: 20949929

 

Orthogonality of SFC versus HPLC for small molecule library separation.

Weller HN, Ebinger K, Bullock W, Edinger KJ, Hermsmeier MA, Hoffman SL, Nirschl DS, Swann T, Zhao J, Kiplinger J, Lefebvre P.

J Comb Chem. 2010 Nov 8;12(6):877-82. doi: 10.1021/cc100118y.

PMID: 20923153

 

Viable mouse gene ablations that robustly alter brain Aβ levels are rare.

Toyn JH, Lin XA, Thompson MW, Guss V, Meredith JE Jr, Sankaranarayanan S, Barrezueta N, Corradi J, Majumdar A, Small DL, Hansard M, Lanthorn T, Westphal RS, Albright CF.

BMC Neurosci. 2010 Nov 5;11:143. doi: 10.1186/1471-2202-11-143.

PMID: 21054826

 

Development and validation of a specific and sensitive GC-FID method for the determination of impurities in 5-chlorovaleroyl chloride.

Tang L, Kim A, Miller SA, Lloyd DK.

J Pharm Biomed Anal. 2010 Nov 2;53(3):309-14. doi: 10.1016/j.jpba.2010.03.042.

PMID: 20439146

 

Ligand-induced changes in hepatitis C virus NS5B polymerase structure.

Rigat K, Wang Y, Hudyma TW, Ding M, Zheng X, Gentles RG, Beno BR, Gao M, Roberts SB.

Antiviral Res. 2010 Nov;88(2):197-206. doi: 10.1016/j.antiviral.2010.08.014.

PMID: 20813137

 

Targeting lymphocyte co-stimulation: from bench to bedside.

Felix NJ, Suri A, Salter-Cid L, Nadler SG, Gujrathi S, Corbo M, Aranda R.

Autoimmunity. 2010 Nov;43(7):514-25. doi: 10.3109/08916931003674741. Review.

PMID: 20429850

 

Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors.

O'Connor SP, Wang Y, Simpkins LM, Brigance RP, Meng W, Wang A, Kirby MS, Weigelt CA, Hamann LG.

Bioorg Med Chem Lett. 2010 Nov 1;20(21):6273-6. doi: 10.1016/j.bmcl.2010.08.090.

PMID: 20833042

 

Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans.

Christopher LJ, Hong H, Vakkalagadda BJ, Clemens PL, Su H, Roongta V, Allentoff A, Sun H, Heller K, Harbison CT, Iyer RA, Humphreys WG, Wong T, Zhang S.

Drug Metab Dispos. 2010 Nov;38(11):2049-59. doi: 10.1124/dmd.110.034850.

PMID: 20668249

 

N-aryl pyrazoles, indazoles and azaindazoles as antagonists of CC chemokine receptor 1: patent cooperation treaty applications WO2010/036632, WO2009/134666 and WO2009/137338.

Carter PH, Hynes J.

Expert Opin Ther Pat. 2010 Nov;20(11):1609-18. doi: 10.1517/13543776.2010.518144.

PMID: 20858032

 

Does the long plasma half-life of 4beta-hydroxycholesterol impact its utility as a cytochrome P450 3A (CYP3A) metric?

Yang Z, Rodrigues AD.

J Clin Pharmacol. 2010 Nov;50(11):1330-8. doi: 10.1177/0091270009360041.

PMID: 20197489

 

Comparative physical, mechanical and crystallographic properties of a series of gemfibrozil salts.

David SE, Ramirez M, Timmins P, Conway BR.

J Pharm Pharmacol. 2010 Nov;62(11):1519-25. doi: 10.1111/j.2042-7158.2010.01025.x.

PMID: 21039537

 

Drug discovery approaches to target Wnt signaling in cancer stem cells.

Curtin JC, Lorenzi MV.

Oncotarget. 2010 Nov;1(7):552-66. Review.

PMID: 21317452

 

Effect of the design of the stopper including dimension, type, and vent area on lyophilization process.

Mungikar A, Ludzinski M, Kamat M.

PDA J Pharm Sci Technol. 2010 Nov-Dec;64(6):507-16.

PMID: 21502061

 

Challenges and promises of developing thrombin receptor antagonists.

Yang J, Xu K, Seiffert D.

Recent Pat Cardiovasc Drug Discov. 2010 Nov;5(3):162-70. Review.

PMID: 20874673

 

Recent strategies for the synthesis of pyridine derivatives.

Hill MD.

Chemistry. 2010 Oct 25;16(40):12052-62. doi: 10.1002/chem.201001100.

PMID: 20827696

 

Sialylation enhancement of CTLA4-Ig fusion protein in Chinese hamster ovary cells by dexamethasone.

Jing Y, Qian Y, Li ZJ.

Biotechnol Bioeng. 2010 Oct 15;107(3):488-96. doi: 10.1002/bit.22827.

PMID: 20521303

 

Application of the Gyrolab™ platform to ligand-binding assays: a user's perspective.

Mora JR, Obenauer-Kutner L, Vimal Patel V.

Bioanalysis. 2010 Oct;2(10):1711-5. doi: 10.4155/bio.10.122.

PMID: 21083323

 

Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.

Lin S, Wrobleski ST, Hynes J Jr, Pitt S, Zhang R, Fan Y, Doweyko AM, Kish KF, Sack JS, Malley MF, Kiefer SE, Newitt JA, McKinnon M, Trzaskos J, Barrish JC, Dodd JH, Schieven GL, Leftheris K.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5864-8. doi: 10.1016/j.bmcl.2010.07.102.

PMID: 20732813

 

Morphological score assignment guidelines for the dechorionated zebrafish teratogenicity assay.

Panzica-Kelly JM, Zhang CX, Danberry TL, Flood A, DeLan JW, Brannen KC, Augustine-Rauch KA.

Birth Defects Res B Dev Reprod Toxicol. 2010 Oct;89(5):382-95. doi: 10.1002/bdrb.20260.

PMID: 20836125

 

Effect of a high-fat meal on the pharmacokinetics of saxagliptin in healthy subjects.

Patel CG, Zhang J, Li L, Gooding L, Croop R, Li T, Boulton DW.

J Clin Pharmacol. 2010 Oct;50(10):1211-6. doi: 10.1177/0091270009360532. No abstract available.

PMID: 20150522

 

Good clinical practice regulatory inspections: Lessons for Indian investigator sites.

Marwah R, Van de Voorde K, Parchman J.

Perspect Clin Res. 2010 Oct;1(4):151-5. doi: 10.4103/2229-3485.71776.

PMID: 21350732

 

The impact of dichotomization in longitudinal data analysis: a simulation study.

Yoo B.

Pharm Stat. 2010 Oct-Dec;9(4):298-312. doi: 10.1002/pst.396.

PMID: 19904810

 

Development of ipilimumab: contribution to a new paradigm for cancer immunotherapy.

Hoos A, Ibrahim R, Korman A, Abdallah K, Berman D, Shahabi V, Chin K, Canetta R, Humphrey R.

Semin Oncol. 2010 Oct;37(5):533-46. doi: 10.1053/j.seminoncol.2010.09.015. Review.

PMID: 21074069

 

Roadmap to risk evaluation and mitigation strategies (REMS) success.

Balian JD, Wherry JC, Malhotra R, Perentesis V.

Ther Adv Drug Saf. 2010 Oct;1(1):21-38. doi: 10.1177/2042098610381419. Review.

PMID: 25083193

 

Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.

Liu C, Lin J, Wrobleski ST, Lin S, Hynes J, Wu H, Dyckman AJ, Li T, Wityak J, Gillooly KM, Pitt S, Shen DR, Zhang RF, McIntyre KW, Salter-Cid L, Shuster DJ, Zhang H, Marathe PH, Doweyko AM, Sack JS, Kiefer SE, Kish KF, Newitt JA, McKinnon M, Dodd JH, Barrish JC, Schieven GL, Leftheris K.

J Med Chem. 2010 Sep 23;53(18):6629-39. doi: 10.1021/jm100540x.

PMID: 20804198

 

Differential mechanisms of acquired resistance to insulin-like growth factor-i receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model.

Huang F, Hurlburt W, Greer A, Reeves KA, Hillerman S, Chang H, Fargnoli J, Graf Finckenstein F, Gottardis MM, Carboni JM.

Cancer Res. 2010 Sep 15;70(18):7221-31. doi: 10.1158/0008-5472.CAN-10-0391.

PMID: 20807811

 

Factor Xa inhibitors: next-generation antithrombotic agents.

Pinto DJ, Smallheer JM, Cheney DL, Knabb RM, Wexler RR.

J Med Chem. 2010 Sep 9;53(17):6243-74. doi: 10.1021/jm100146h. Review. No abstract available.

PMID: 20503967

 

The use of inductively coupled plasma-atomic emission spectroscopy (ICP-AES) in the determination of lithium in cleaning validation swabs.

Lewen N, Nugent D.

J Pharm Biomed Anal. 2010 Sep 5;52(5):652-5. doi: 10.1016/j.jpba.2010.02.015.

PMID: 20227219

 

A novel small molecule inhibitor of hepatitis C virus entry.

Baldick CJ, Wichroski MJ, Pendri A, Walsh AW, Fang J, Mazzucco CE, Pokornowski KA, Rose RE, Eggers BJ, Hsu M, Zhai W, Zhai G, Gerritz SW, Poss MA, Meanwell NA, Cockett MI, Tenney DJ.

PLoS Pathog. 2010 Sep 2;6(9):e1001086. doi: 10.1371/journal.ppat.1001086.

PMID: 20838466

 

Structural mass spectrometry in protein therapeutics discovery.

Kim YJ, Doyle ML.

Anal Chem. 2010 Sep 1;82(17):7083-9. doi: 10.1021/ac101575d.

PMID: 20698501

 

Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system.

Fridell RA, Qiu D, Wang C, Valera L, Gao M.

Antimicrob Agents Chemother. 2010 Sep;54(9):3641-50. doi: 10.1128/AAC.00556-10.

PMID: 20585111

 

Development and validation of flow cytometry methods for pharmacodynamic clinical biomarkers.

Wu DY, Patti-Diaz L, Hill CG.

Bioanalysis. 2010 Sep;2(9):1617-26. doi: 10.4155/bio.10.33. Review.

PMID: 21083290

 

Characterization and development of a Luminex(®)-based assay for the detection of human IL-23.

Rizzi G, Zhang YJ, Latek R, Weiner R, Rhyne PW.

Bioanalysis. 2010 Sep;2(9):1561-72. doi: 10.4155/bio.10.68.

PMID: 21083285

 

Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.

Sampognaro AJ, Wittman MD, Carboni JM, Chang C, Greer AF, Hurlburt WW, Sack JS, Vyas DM.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5027-30. doi: 10.1016/j.bmcl.2010.07.045.

PMID: 20675137

 

Glucocorticoid receptor-mediated reduction of IgG-fusion protein aggregation in Chinese hamster ovary cells.

Qian Y, Jing Y, Li ZJ.

Biotechnol Prog. 2010 Sep-Oct;26(5):1417-23. doi: 10.1002/btpr.456.

PMID: 20549677

 

Quantification of apixaban's therapeutic utility in prevention of venous thromboembolism: selection of phase III trial dose.

Leil TA, Feng Y, Zhang L, Paccaly A, Mohan P, Pfister M.

Clin Pharmacol Ther. 2010 Sep;88(3):375-82. doi: 10.1038/clpt.2010.106.

PMID: 20686477

 

Insulin receptor (IR) pathway hyperactivity in IGF-IR null cells and suppression of downstream growth signaling using the dual IGF-IR/IR inhibitor, BMS-754807.

Dinchuk JE, Cao C, Huang F, Reeves KA, Wang J, Myers F, Cantor GH, Zhou X, Attar RM, Gottardis M, Carboni JM.

Endocrinology. 2010 Sep;151(9):4123-32. doi: 10.1210/en.2010-0032.

PMID: 20610571

 

Development and validation of sensitive and selective LC-MS/MS methods for the determination of BMS-708163, a gamma-secretase inhibitor, in plasma and cerebrospinal fluid using deprotonated or formate adduct ions as precursor ions.

Gu H, Deng Y, Wang J, Aubry AF, Arnold ME.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2319-26. doi: 10.1016/j.jchromb.2010.06.041.

PMID: 20674522

 

Fostering culture and optimizing organizational structure for implementing model-based drug development.

Zhang L, Allerheiligen SR, Lalonde RL, Stanski DR, Pfister M.

J Clin Pharmacol. 2010 Sep;50(9 Suppl):146S-150S. doi: 10.1177/0091270010376976.

PMID: 20881228

 

Synergy between scientific advancement and technological innovation, illustrated by a mechanism-based model characterizing sodium-glucose cotransporter-2 inhibition.

Zhang L, Ng CM, List JF, Pfister M.

J Clin Pharmacol. 2010 Sep;50(9 Suppl):113S-120S. doi: 10.1177/0091270010376974.

PMID: 20881224

 

Use of enthalpy and Gibbs free energy to evaluate the risk of amorphous formation.

Hsieh DS, Sarsfield BA, Davidovich M, DiMemmo LM, Chang SY, Kiang S.

J Pharm Sci. 2010 Sep;99(9):4096-105. doi: 10.1002/jps.22239.

PMID: 20564337

 

Solid-state interactions of a drug substance and excipients and their impact on tablet dissolution: a thermal-mechanical facilitated process-induced transformation or PIT.

Wang J, Davidovich M, Desai D, Bu D, Hussain M, Morris K.

J Pharm Sci. 2010 Sep;99(9):3849-62. doi: 10.1002/jps.22222.

PMID: 20533436

 

Chronic hepatitis B: perceptions in Asian American communities and diagnosis and management practices among primary care physicians.

Upadhyaya N, Chang R, Davis C, Conti MC, Salinas-Garcia D, Tang H.

Postgrad Med. 2010 Sep;122(5):165-75. doi: 10.3810/pgm.2010.09.2213.

PMID: 20861600

 

Improved survival with ipilimumab in patients with metastatic melanoma.

Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, van den Eertwegh AJ, Lutzky J, Lorigan P, Vaubel JM, Linette GP, Hogg D, Ottensmeier CH, Lebbé C, Peschel C, Quirt I, Clark JI, Wolchok JD, Weber JS, Tian J, Yellin MJ, Nichol GM, Hoos A, Urba WJ.

N Engl J Med. 2010 Aug 19;363(8):711-23. doi: 10.1056/NEJMoa1003466. Erratum in: N Engl J Med. 2010 Sep 23;363(13):1290.

PMID:

 

Is a distinctive single Tg a reliable indicator for the homogeneity of amorphous solid dispersion?

Qian F, Huang J, Zhu Q, Haddadin R, Gawel J, Garmise R, Hussain M.

Int J Pharm. 2010 Aug 16;395(1-2):232-5. doi: 10.1016/j.ijpharm.2010.05.033.

PMID: 20562003

  

Defining process design space for monoclonal antibody cell culture.

Abu-Absi SF, Yang L, Thompson P, Jiang C, Kandula S, Schilling B, Shukla AA.

Biotechnol Bioeng. 2010 Aug 15;106(6):894-905. doi: 10.1002/bit.22764.

PMID: 20589669

 

Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.

Meng W, Brigance RP, Chao HJ, Fura A, Harrity T, Marcinkeviciene J, O'Connor SP, Tamura JK, Xie D, Zhang Y, Klei HE, Kish K, Weigelt CA, Turdi H, Wang A, Zahler R, Kirby MS, Hamann LG.

J Med Chem. 2010 Aug 12;53(15):5620-8. doi: 10.1021/jm100634a.

PMID: 20684603

 

One-pot synthesis of azaindoles via palladium-catalyzed alpha-heteroarylation of ketone enolates.

Spergel SH, Okoro DR, Pitts W.

J Org Chem. 2010 Aug 6;75(15):5316-9. doi: 10.1021/jo100623d.

PMID: 20593785

 

Effect of inadequate response to treatment in patients with depression.

Knoth RL, Bolge SC, Kim E, Tran QV.

Am J Manag Care. 2010 Aug;16(8):e188-96.

PMID: 20690785

 

Liquid-liquid extraction coupled with LC/MS/MS for monitoring of malonyl-CoA in rat brain tissue.

Onorato JM, Chen L, Shipkova P, Ma Z, Azzara AV, Devenny JJ, Liang N, Haque TS, Cheng D.

Anal Bioanal Chem. 2010 Aug;397(7):3137-42. doi: 10.1007/s00216-010-3879-1.

PMID: 20549491

 

DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors.

D'Arienzo CJ, Ji QC, Discenza L, Cornelius G, Hynes J, Cornelius L, Santella JB, Olah T.

Bioanalysis. 2010 Aug;2(8):1415-22. doi: 10.4155/bio.10.94.

PMID: 21083342

 

Evaluating and defining sample preparation procedures for DBS LC-MS/MS assays.

Liu G, Patrone L, Snapp HM, Batog A, Valentine J, Cosma G, Tymiak A, Ji QC, Arnold ME.

Bioanalysis. 2010 Aug;2(8):1405-14. doi: 10.4155/bio.10.106.

PMID: 21083341

 

Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes.

Brigance RP, Meng W, Fura A, Harrity T, Wang A, Zahler R, Kirby MS, Hamann LG.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4395-8. doi: 10.1016/j.bmcl.2010.06.063.

PMID: 20598534

 

Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists.

Xiao HY, Balog A, Attar RM, Fairfax D, Fleming LB, Holst CL, Martin GS, Rossiter LM, Chen J, Cvjic ME, Dell-John J, Geng J, Gottardis MM, Han WC, Nation A, Obermeier M, Rizzo CA, Schweizer L, Spires T Jr, Shan W, Gavai A, Salvati ME, Vite G.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4491-5. doi: 10.1016/j.bmcl.2010.06.034.

PMID: 20584610

 

The impact of hepatitis C virus infection on work absence, productivity, and healthcare benefit costs.

Su J, Brook RA, Kleinman NL, Corey-Lisle P.

Hepatology. 2010 Aug;52(2):436-42. doi: 10.1002/hep.23726.

PMID: 20683943

 

HCS road: an enterprise system for integrated HCS data management and analysis.

Jackson D, Lenard M, Zelensky A, Shaikh M, Scharpf JV, Shaginaw R, Nawade M, Agler M, Cloutier NJ, Fennell M, Guo Q, Wardwell-Swanson J, Zhao D, Zhu Y, Miller C, Gill J.

J Biomol Screen. 2010 Aug;15(7):882-91. doi: 10.1177/1087057110374233.

PMID: 20639503

 

Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2.

Marathe P, Tang Y, Sleczka B, Rodrigues D, Gavai A, Wong T, Christopher L, Zhang H.

J Pharm Sci. 2010 Aug;99(8):3579-93. doi: 10.1002/jps.22099.

PMID: 20166197

 

Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin.

Wong PC, Jiang X.

Thromb Haemost. 2010 Aug;104(2):302-10. doi: 10.1160/TH10-02-0097.

PMID: 20589316

 

BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies.

Wong PC, Luettgen JM, Rendina AR, Kettner CA, Xin B, Knabb RM, Wexler R, Priestley ES.

Thromb Haemost. 2010 Aug;104(2):261-9. doi: 10.1160/TH10-01-0025.

PMID: 20589312

 

Paracelsus and formaldehyde 2010: the dose to the target organ makes the poison.

Lehman-McKeeman L.

Toxicol Sci. 2010 Aug;116(2):361-3. doi: 10.1093/toxsci/kfq164. No abstract available.

PMID: 20587505

 

Use of high-resolution mass spectrometry to investigate a metabolite interference during liquid chromatography/tandem mass spectrometric quantification of a small molecule in toxicokinetic study samples.

Furlong M, Bessire A, Song W, Huntington C, Groeber E.

Rapid Commun Mass Spectrom. 2010 Jul 15;24(13):1902-10. doi: 10.1002/rcm.4587.

PMID: 20533320

 

An electrophoretic mobility shift assay for the identification and kinetic analysis of acetyl transferase inhibitors.

Fanslau C, Pedicord D, Nagulapalli S, Gray H, Pang S, Jayaraman L, Lippy J, Blat Y.

Anal Biochem. 2010 Jul 1;402(1):65-8. doi: 10.1016/j.ab.2010.03.025.

PMID: 20338149

 

Novel MS solutions inspired by MIST.

Ramanathan R, Josephs JL, Jemal M, Arnold M, Humphreys WG.

Bioanalysis. 2010 Jul;2(7):1291-313. doi: 10.4155/bio.10.83. Review.

PMID: 21083241

 

NMR spectroscopy as a tool to close the gap on metabolite characterization under MIST.

Caceres-Cortes J, Reily MD.

Bioanalysis. 2010 Jul;2(7):1263-76. doi: 10.4155/bio.10.77. Review.

PMID: 21083239

 

Conference report: Inaugural Applied Pharmaceutical Analysis: India 2010 conference.

Ramanathan R, Chaudhary A.

Bioanalysis. 2010 Jul;2(7):1181-4. doi: 10.4155/bio.10.78.

PMID: 21083232

 

The use of mechanistic biomarkers for evaluating investigational CNS compounds in early drug development.

Soares HD.

Curr Opin Investig Drugs. 2010 Jul;11(7):795-801. Review.

PMID: 20571975

 

A simple and promising tool to improve self-monitoring of blood glucose in patients with diabetes.

Nadkarni A, Kucukarslan SN, Bagozzi RP, Yates JF, Erickson SR.

Diabetes Res Clin Pract. 2010 Jul;89(1):30-7. doi: 10.1016/j.diabres.2010.03.011.

PMID: 20381890

 

Metabolism and disposition of [14C]BMS-690514 after oral administration to rats, rabbits, and dogs.

Hong H, Su H, Sun H, Allentoff A, Ekhato IV, Chando T, Caceres-Cortes J, Roongta V, Iyer RA, Humphreys WG, Christopher LJ.

Drug Metab Dispos. 2010 Jul;38(7):1189-201. doi: 10.1124/dmd.110.032755.

PMID: 20363952

 

Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human kidney drug transporters.

Han YH, Busler D, Hong Y, Tian Y, Chen C, Rodrigues AD.

Drug Metab Dispos. 2010 Jul;38(7):1064-71. doi: 10.1124/dmd.109.031526.

PMID: 20360303

 

Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human liver drug transporters.

Han YH, Busler D, Hong Y, Tian Y, Chen C, Rodrigues AD.

Drug Metab Dispos. 2010 Jul;38(7):1072-82. doi: 10.1124/dmd.109.031518.

PMID: 20360302

 

A simple reversed phase high-performance liquid chromatography method for polysorbate 80 quantitation in monoclonal antibody drug products.

Adamo M, Dick LW Jr, Qiu D, Lee AH, Devincentis J, Cheng KC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1865-70. doi: 10.1016/j.jchromb.2010.04.039.

PMID: 20537600

 

Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases.

Zhao Q.

J Leukoc Biol. 2010 Jul;88(1):41-55. doi: 10.1189/jlb.1009671. Review.

PMID: 20360402

 

Drug-polymer solubility and miscibility: Stability consideration and practical challenges in amorphous solid dispersion development.

Qian F, Huang J, Hussain MA.

J Pharm Sci. 2010 Jul;99(7):2941-7. doi: 10.1002/jps.22074.

PMID: 20127825

 

Modeling of pan coating processes: Prediction of tablet content uniformity and determination of critical process parameters.

Chen W, Chang SY, Kiang S, Marchut A, Lyngberg O, Wang J, Rao V, Desai D, Stamato H, Early W.

J Pharm Sci. 2010 Jul;99(7):3213-25. doi: 10.1002/jps.22044.

PMID: 20091834

 

Exploration of structure-activity relationships at the two C-terminal residues of potent 11mer Glucagon-Like Peptide-1 receptor agonist peptides via parallel synthesis.

Haque TS, Martinez RL, Lee VG, Riexinger DG, Lei M, Feng M, Koplowitz B, Mapelli C, Cooper CB, Zhang G, Huang C, Ewing WR, Krupinski J.

Peptides. 2010 Jul;31(7):1353-60. doi: 10.1016/j.peptides.2010.04.013.

PMID: 20420872

 

Effect of spray-dried mannitol on the performance of microcrystalline cellulose-based wet granulated tablet formulation.

Badawy SI, Shah KR, Surapaneni MS, Szemraj MM, Hussain M.

Pharm Dev Technol. 2010 Jul-Aug;15(4):339-45. doi: 10.3109/10837450903229065.

PMID: 20088677

 

MORPH: a new tool for ligand design.

Beno BR, Langley DR.

J Chem Inf Model. 2010 Jun 28;50(6):1159-64. doi: 10.1021/ci9004964.

PMID: 20481489

 

Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial.

Bailey CJ, Gross JL, Pieters A, Bastien A, List JF.

Lancet. 2010 Jun 26;375(9733):2223-33. doi: 10.1016/S0140-6736(10)60407-2.

PMID: 20609968

 

5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists.

Schmitz WD, Brenner AB, Bronson JJ, Ditta JL, Griffin CR, Li YW, Lodge NJ, Molski TF, Olson RE, Zhuo X, Macor JE.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3579-83. doi: 10.1016/j.bmcl.2010.04.121.

PMID: 20483614

 

Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists.

Zuev D, Vrudhula VM, Michne JA, Dasgupta B, Pin SS, Huang XS, Wu D, Gao Q, Zhang J, Taber MT, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3669-74. doi: 10.1016/j.bmcl.2010.04.094.

PMID: 20471832

 

Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naïve subjects in the CASTLE study.

Lataillade M, Chiarella J, Yang R, Schnittman S, Wirtz V, Uy J, Seekins D, Krystal M, Mancini M, McGrath D, Simen B, Egholm M, Kozal M.

PLoS One. 2010 Jun 3;5(6):e10952. doi: 10.1371/journal.pone.0010952.

PMID: 20532178

 

In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays.

Augustine-Rauch K, Zhang CX, Panzica-Kelly JM.

Birth Defects Res C Embryo Today. 2010 Jun;90(2):87-98. doi: 10.1002/bdrc.20175. Review.

PMID: 20544698

 

Non-competitive inhibition by active site binders.

Blat Y.

Chem Biol Drug Des. 2010 Jun;75(6):535-40. doi: 10.1111/j.1747-0285.2010.00972.x. Review.

PMID: 20374252

 

Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight.

Zhang L, Feng Y, List J, Kasichayanula S, Pfister M.

Diabetes Obes Metab. 2010 Jun;12(6):510-6. doi: 10.1111/j.1463-1326.2010.01216.x.

PMID: 20518806

 

Effect of the direct factor Xa inhibitor apixaban in rat models of thrombosis and hemostasis.

Schumacher WA, Bostwick JS, Stewart AB, Steinbacher TE, Xin B, Wong PC.

J Cardiovasc Pharmacol. 2010 Jun;55(6):609-16. doi: 10.1097/FJC.0b013e3181daded3.

PMID: 20224421

 

LC-MS/MS method using unbonded silica column and aqueous/methanol mobile phase for the simultaneous quantification of a drug candidate and co-administered metformin in rat plasma.

Discenza L, D'Arienzo C, Olah T, Jemal M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jun 1;878(19):1583-9. doi: 10.1016/j.jchromb.2010.04.018.

PMID: 20451474

 

Colloidal phase behavior of pH-responsive, amphiphilic PEGylated poly(carboxylic acid)s and effect on kinetic solubility under acidic conditions.

Adams ML, Rao VM, Thakur A, Hussain MA.

Pharm Dev Technol. 2010 Jun;15(3):266-75. doi: 10.3109/10837450903170772.

PMID: 22716467

 

Roller compaction: application of an in-gap ribbon porosity calculation for the optimization of downstream granule flow and compactability characteristics.

Gamble JF, Tobyn M, Dennis AB, Shah T.

Pharm Dev Technol. 2010 Jun;15(3):223-9. doi: 10.3109/10837450903095342.

PMID: 22716462

 

Muscling mussels: metabolomic evaluation of toxicity.

Robertson DG.

Toxicol Sci. 2010 Jun;115(2):305-6. doi: 10.1093/toxsci/kfq088. No abstract available.

PMID: 20478983

 

Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.

Ruan Q, Zhu M.

Chem Res Toxicol. 2010 May 17;23(5):909-17. doi: 10.1021/tx1000046.

PMID: 20297803

 

Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.

Velaparthi U, Saulnier MG, Wittman MD, Liu P, Frennesson DB, Zimmermann K, Carboni JM, Gottardis M, Li A, Greer A, Clarke W, Yang Z, Menard K, Lee FY, Trainor G, Vyas D.

Bioorg Med Chem Lett. 2010 May 15;20(10):3182-5. doi: 10.1016/j.bmcl.2010.03.057.

PMID: 20399649

 

Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).

Watterson SH, Xiao Z, Dodd DS, Tortolani DR, Vaccaro W, Potin D, Launay M, Stetsko DK, Skala S, Davis PM, Lee D, Yang X, McIntyre KW, Balimane P, Patel K, Yang Z, Marathe P, Kadiyala P, Tebben AJ, Sheriff S, Chang CY, Ziemba T, Zhang H, Chen BC, DelMonte AJ, Aranibar N, McKinnon M, Barrish JC, Suchard SJ, Murali Dhar TG.

J Med Chem. 2010 May 13;53(9):3814-30. doi: 10.1021/jm100348u.

PMID: 20405922

 

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.

Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O'Boyle DR 2nd, Lemm JA, Wang C, Knipe JO, Chien C, Colonno RJ, Grasela DM, Meanwell NA, Hamann LG.

Nature. 2010 May 6;465(7294):96-100. doi: 10.1038/nature08960.

PMID: 20410884

 

Pooled sample strategy in conjunction with high-resolution liquid chromatography-mass spectrometry-based background subtraction to identify toxicological markers in dogs treated with ibipinabant.

Zhang H, Patrone L, Kozlosky J, Tomlinson L, Cosma G, Horvath J.

Anal Chem. 2010 May 1;82(9):3834-9. doi: 10.1021/ac100287a.

PMID: 20387806

 

Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors.

Zhang S, Alexander L, Wang T, Agler M, Zhou N, Fang H, Kadow J, Clapham P, Lin PF.

Arch Virol. 2010 May;155(5):777-81. doi: 10.1007/s00705-010-0644-x.

PMID: 20300783

 

Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.

Williams DK, Chen XT, Tarby C, Kaltenbach R, Cai ZW, Tokarski JS, An Y, Sack JS, Wautlet B, Gullo-Brown J, Henley BJ, Jeyaseelan R, Kellar K, Manne V, Trainor GL, Lombardo LJ, Fargnoli J, Borzilleri RM.

Bioorg Med Chem Lett. 2010 May 1;20(9):2998-3002. doi: 10.1016/j.bmcl.2010.01.042.

PMID: 20382527

 

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Ye XY, Chen S, Zhang H, Locke KT, O'Malley K, Zhang L, Srivastava R, Miao B, Meyers D, Monshizadegan H, Search D, Grimm D, Zhang R, Lippy J, Twamley C, Muckelbauer JK, Chang C, An Y, Hosagrahara V, Zhang L, Yang TJ, Mukherjee R, Cheng PT, Tino JA.

Bioorg Med Chem Lett. 2010 May 1;20(9):2933-7. doi: 10.1016/j.bmcl.2010.03.019.

PMID: 20356736

 

Disaggregation of high-molecular weight species during downstream processing to recover functional monomer.

Xu X, Didio DM, Leister KJ, Ghose S.

Biotechnol Prog. 2010 May-Jun;26(3):717-26. doi: 10.1002/btpr.373.

PMID: 20039266

 

Feed development for fed-batch CHO production process by semisteady state analysis.

Khattak SF, Xing Z, Kenty B, Koyrakh I, Li ZJ.

Biotechnol Prog. 2010 May-Jun;26(3):797-804. doi: 10.1002/btpr.362.

PMID: 20014108

 

Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder.

Coric V, Feldman HH, Oren DA, Shekhar A, Pultz J, Dockens RC, Wu X, Gentile KA, Huang SP, Emison E, Delmonte T, D'Souza BB, Zimbroff DL, Grebb JA, Goddard AW, Stock EG.

Depress Anxiety. 2010 May;27(5):417-25. doi: 10.1002/da.20695.

PMID: 20455246

 

Lubrication in tablet formulations.

Wang J, Wen H, Desai D.

Eur J Pharm Biopharm. 2010 May;75(1):1-15. doi: 10.1016/j.ejpb.2010.01.007. Review.

PMID: 20096779

 

Effect of body position on limb lead electrocardiographic findings in sedated cynomolgus macaques (Macaca fascicularis).

Taylor K, Gleason C.

J Am Assoc Lab Anim Sci. 2010 May;49(3):352-6.

PMID: 20587168

 

A tris (2-carboxyethyl) phosphine (TCEP) related cleavage on cysteine-containing proteins.

Liu P, O'Mara BW, Warrack BM, Wu W, Huang Y, Zhang Y, Zhao R, Lin M, Ackerman MS, Hocknell PK, Chen G, Tao L, Rieble S, Wang J, Wang-Iverson DB, Tymiak AA, Grace MJ, Russell RJ.

J Am Soc Mass Spectrom. 2010 May;21(5):837-44. doi: 10.1016/j.jasms.2010.01.016.

PMID: 20189823

 

Identification of potent 11mer glucagon-like peptide-1 receptor agonist peptides with novel C-terminal amino acids: Homohomophenylalanine analogs.

Haque TS, Lee VG, Riexinger D, Lei M, Malmstrom S, Xin L, Han S, Mapelli C, Cooper CB, Zhang G, Ewing WR, Krupinski J.

Peptides. 2010 May;31(5):950-5. doi: 10.1016/j.peptides.2010.01.008.

PMID: 20138099

 

A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes.

Frederich R, Alexander JH, Fiedorek FT, Donovan M, Berglind N, Harris S, Chen R, Wolf R, Mahaffey KW.

Postgrad Med. 2010 May;122(3):16-27. doi: 10.3810/pgm.2010.05.2138.

PMID: 20463410

 

Recent advances in large-scale production of monoclonal antibodies and related proteins.

Shukla AA, Thömmes J.

Trends Biotechnol. 2010 May;28(5):253-61. doi: 10.1016/j.tibtech.2010.02.001. Review.

PMID: 20304511

 

Phospholipidosis as a function of basicity, lipophilicity, and volume of distribution of compounds.

Hanumegowda UM, Wenke G, Regueiro-Ren A, Yordanova R, Corradi JP, Adams SP.

Chem Res Toxicol. 2010 Apr 19;23(4):749-55. doi: 10.1021/tx9003825.

PMID: 20356072

 

gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Mo R, Meyer DT, Voss ME, Yang MG, Santella JB 3rd, Duncia JV, Lo YC, Yang G, Miller PB, Scherle PA, Zhao Q, Mandlekar S, Cvijic ME, Barrish JC, Decicco CP, Carter PH.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2425-30. doi: 10.1016/j.bmcl.2010.03.035.

PMID: 20346664

 

Effects of culture conditions on N-glycolylneuraminic acid (Neu5Gc) content of a recombinant fusion protein produced in CHO cells.

Borys MC, Dalal NG, Abu-Absi NR, Khattak SF, Jing Y, Xing Z, Li ZJ.

Biotechnol Bioeng. 2010 Apr 15;105(6):1048-57. doi: 10.1002/bit.22644.

PMID: 20039310

 

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

Li J, Kennedy LJ, Shi Y, Tao S, Ye XY, Chen SY, Wang Y, Hernández AS, Wang W, Devasthale PV, Chen S, Lai Z, Zhang H, Wu S, Smirk RA, Bolton SA, Ryono DE, Zhang H, Lim NK, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M, Kadiyala P, Hosagrahara V, Zhang L, Xu C, Li YX, Muckelbauer JK, Chang C, An Y, Krystek SR, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA.

J Med Chem. 2010 Apr 8;53(7):2854-64. doi: 10.1021/jm9016812.

PMID: 20218621

 

Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method.

Browning MR, Drexler DM, Olah TV, Morgan DG.

Bioanalysis. 2010 Apr;2(4):745-53. doi: 10.4155/bio.10.25.

PMID: 21083272

 

Effective screening approach to select esterase inhibitors used for stabilizing ester-containing prodrugs analyzed by LC-MS/MS.

Fung EN, Zheng N, Arnold ME, Zeng J.

Bioanalysis. 2010 Apr;2(4):733-43. doi: 10.4155/bio.10.30.

PMID: 21083271

 

Semiparametric Bayesian inference for repeated fractional measurement data.

Yang Y, Müller P, Rosner GL.

Chil J Stat. 2010 Apr 1;1(1):59-74.

PMID: 21822354

 

Disposition of [1'-(14)C]stavudine after oral administration to humans.

Zhou L, Kaul S, Liu-Kreyche P, Tran SB, Espina RR, Warrack BM, Roongta VA, Iyer RA.

Drug Metab Dispos. 2010 Apr;38(4):655-66. doi: 10.1124/dmd.109.030239.

PMID: 20053818

 

An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.

Suchard SJ, Stetsko DK, Davis PM, Skala S, Potin D, Launay M, Dhar TG, Barrish JC, Susulic V, Shuster DJ, McIntyre KW, McKinnon M, Salter-Cid L.

J Immunol. 2010 Apr 1;184(7):3917-26. doi: 10.4049/jimmunol.0901095.

PMID: 20190141

 

Bacterial infections in cynomolgus monkeys given small molecule immunomodulatory antagonists.

Price KD.

J Immunotoxicol. 2010 Apr-Jun;7(2):128-37. doi: 10.3109/15476910903493276. Review.

PMID: 20136396

 

Overview of known non-human primate pathogens with potential to affect colonies used for toxicity testing.

Sasseville VG, Mansfield KG.

J Immunotoxicol. 2010 Apr-Jun;7(2):79-92. doi: 10.3109/15476910903213521. Review.

PMID: 19909217

 

Clinical veterinarian's perspective of non-human primate (NHP) use in drug safety studies.

Taylor K.

J Immunotoxicol. 2010 Apr-Jun;7(2):114-9. doi: 10.1080/15476910903213539. Review.

PMID: 19775234

 

Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.

Yang Z, Zadjura LM, Marino AM, D'Arienzo CJ, Malinowski J, Gesenberg C, Lin PF, Colonno RJ, Wang T, Kadow JF, Meanwell NA, Hansel SB.

J Pharm Sci. 2010 Apr;99(4):2135-52. doi: 10.1002/jps.21948.

PMID: 19780144

 

The pharmacokinetics of standard antidepressants with aripiprazole as adjunctive therapy: studies in healthy subjects and in patients with major depressive disorder.

Boulton DW, Balch AH, Royzman K, Patel CG, Berman RM, Mallikaarjun S, Reeves RA.

J Psychopharmacol. 2010 Apr;24(4):537-46. doi: 10.1177/0269881108096522.

PMID: 18832427

 

Impact of missing data on type 1 error rates in non-inferiority trials.

Yoo B.

Pharm Stat. 2010 Apr-Jun;9(2):87-99. doi: 10.1002/pst.378.

PMID: 19408241

 

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.

Gillman KW, Starrett JE Jr, Parker MF, Xie K, Bronson JJ, Marcin LR, McElhone KE, Bergstrom CP, Mate RA, Williams R, Meredith JE Jr, Burton CR, Barten DM, Toyn JH, Roberts SB, Lentz KA, Houston JG, Zaczek R, Albright CF, Decicco CP, Macor JE, Olson RE.

ACS Med Chem Lett. 2010 Mar 22;1(3):120-4. doi: 10.1021/ml1000239.

PMID: 24900185

 

Copper-catalyzed chlorination of functionalized arylboronic acids.

Wu H, Hynes J Jr.

Org Lett. 2010 Mar 19;12(6):1192-5. doi: 10.1021/ol9029337.

PMID: 20184339

 

Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF1R).

Vrudhula VM, Dasgupta B, Pin SS, Burris KD, Balanda LA, Fung LK, Fiedler T, Browman KE, Taber MT, Zhang J, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1905-9. doi: 10.1016/j.bmcl.2010.01.127.

PMID: 20185312

 

Synthesis and structure-activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.

Hartz RA, Ahuja VT, Schmitz WD, Molski TF, Mattson GK, Lodge NJ, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1890-4. doi: 10.1016/j.bmcl.2010.01.129.

PMID: 20176478

 

Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial.

Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Hornick P; ADVANCE-2 investigators..

Lancet. 2010 Mar 6;375(9717):807-15. doi: 10.1016/S0140-6736(09)62125-5.

PMID: 20206776

 

Mild and general method for the alpha-arylation of heteroaromatic ketones.

Desai LV, Ren DT, Rosner T.

Org Lett. 2010 Mar 5;12(5):1032-5. doi: 10.1021/ol1000318.

PMID: 20146430

 

Inhibition of factor XIa as a new approach to anticoagulation.

Schumacher WA, Luettgen JM, Quan ML, Seiffert DA.

Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):388-92. doi: 10.1161/ATVBAHA.109.197178. Review.

PMID: 20139363

 

SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.

Zimmermann K, Wittman MD, Saulnier MG, Velaparthi U, Sang X, Frennesson DB, Struzynski C, Seitz SP, He L, Carboni JM, Li A, Greer AF, Gottardis M, Attar RM, Yang Z, Balimane P, Discenza LN, Lee FY, Sinz M, Kim S, Vyas D.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1744-8. doi: 10.1016/j.bmcl.2010.01.087.

PMID: 20153189

 

Treatment patterns in patients with advanced breast cancer who were exposed to an anthracycline, a taxane, and capecitabine: a descriptive report.

Donato BM, Burns L, Willey V, Cohenuram M, Oliveria S, Yood MU.

Clin Ther. 2010 Mar;32(3):546-54. doi: 10.1016/j.clinthera.2010.03.007.

PMID: 20399992

 

In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans.

Obermeier M, Yao M, Khanna A, Koplowitz B, Zhu M, Li W, Komoroski B, Kasichayanula S, Discenza L, Washburn W, Meng W, Ellsworth BA, Whaley JM, Humphreys WG.

Drug Metab Dispos. 2010 Mar;38(3):405-14. doi: 10.1124/dmd.109.029165.

PMID: 19996149

 

In silico prediction of biliary excretion of drugs in rats based on physicochemical properties.

Luo G, Johnson S, Hsueh MM, Zheng J, Cai H, Xin B, Chong S, He K, Harper TW.

Drug Metab Dispos. 2010 Mar;38(3):422-30. doi: 10.1124/dmd.108.026260.

PMID: 19995888

 

 In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.

Wang L, Zhang D, Raghavan N, Yao M, Ma L, Frost CE, Maxwell BD, Chen SY, He K, Goosen TC, Humphreys WG, Grossman SJ.

Drug Metab Dispos. 2010 Mar;38(3):448-58. doi: 10.1124/dmd.109.029694. Erratum in: Drug Metab Dispos. 2010 May;38(5):887. Frost, Charles A [corrected to Frost, Charles E].

PMID: 19940026

 

Recent development in high-throughput bioanalytical support for in vitro ADMET profiling.

Shou WZ, Zhang J.

Expert Opin Drug Metab Toxicol. 2010 Mar;6(3):321-36. doi: 10.1517/17425250903547829. Review.

PMID: 20163321

 

Indirect cost-effectiveness analyses of abatacept and rituximab in patients with moderate-to-severe rheumatoid arthritis in the United States.

Yuan Y, Trivedi D, Maclean R, Rosenblatt L.

J Med Econ. 2010 Mar;13(1):33-41. doi: 10.3111/13696990903508021.

PMID: 20001596

 

Applications of HILIC for targeted and non-targeted LC/MS analyses in drug discovery.

Onorato JM, Langish R, Bellamine A, Shipkova P.

J Sep Sci. 2010 Mar;33(6-7):923-9. doi: 10.1002/jssc.200900659.

PMID: 20127913

 

Risk of pancreatic cancer in chronic hepatitis B virus infection: data from the REVEAL-HBV cohort study.

Iloeje UH, Yang HI, Jen CL, Su J, Wang LY, You SL, Lu SN, Chen CJ.

Liver Int. 2010 Mar;30(3):423-9. doi: 10.1111/j.1478-3231.2009.02147.x.

PMID: 19840258

 

Anti-tumor effect of CT-322 as an adnectin inhibitor of vascular endothelial growth factor receptor-2.

Mamluk R, Carvajal IM, Morse BA, Wong H, Abramowitz J, Aslanian S, Lim AC, Gokemeijer J, Storek MJ, Lee J, Gosselin M, Wright MC, Camphausen RT, Wang J, Chen Y, Miller K, Sanders K, Short S, Sperinde J, Prasad G, Williams S, Kerbel R, Ebos J, Mutsaers A, Mendlein JD, Harris AS, Furfine ES.

MAbs. 2010 Mar-Apr;2(2):199-208.

PMID: 20190562

 

Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer.

Khambata-Ford S, Harbison CT, Hart LL, Awad M, Xu LA, Horak CE, Dakhil S, Hermann RC, Lynch TJ, Weber MR.

J Clin Oncol. 2010 Feb 20;28(6):918-27. doi: 10.1200/JCO.2009.25.2890.

PMID: 20100958

 

Phenyltriazolinones as potent factor Xa inhibitors.

Quan ML, Pinto DJ, Rossi KA, Sheriff S, Alexander RS, Amparo E, Kish K, Knabb RM, Luettgen JM, Morin P, Smallwood A, Woerner FJ, Wexler RR.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1373-7. doi: 10.1016/j.bmcl.2010.01.011.

PMID: 20100660

 

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers.

Lloyd J, Finlay HJ, Vacarro W, Hyunh T, Kover A, Bhandaru R, Yan L, Atwal K, Conder ML, Jenkins-West T, Shi H, Huang C, Li D, Sun H, Levesque P.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1436-9. doi: 10.1016/j.bmcl.2009.12.085.

PMID: 20097068

 

Liquid chromatography and tandem mass spectrometry for the quantitative determination of ixabepilone (BMS-247550, Ixempra) in human plasma: method validation, overcoming curve splitting issues and eliminating chromatographic interferences from degradants.

Xu XS, Zeng J, Mylott W, Arnold M, Waltrip J, Iacono L, Mariannino T, Stouffer B.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 15;878(5-6):525-37. doi: 10.1016/j.jchromb.2009.12.014.

PMID: 20083444

 

Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.

Walsh AW, Langley DR, Colonno RJ, Tenney DJ.

PLoS One. 2010 Feb 12;5(2):e9195. doi: 10.1371/journal.pone.0009195.

PMID: 20169198

 

Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators.

Xiao HY, Wu DR, Malley MF, Gougoutas JZ, Habte SF, Cunningham MD, Somerville JE, Dodd JH, Barrish JC, Nadler SG, Dhar TG.

J Med Chem. 2010 Feb 11;53(3):1270-80. doi: 10.1021/jm901551w.

PMID: 20047280

 

Bioavailability in healthy adults of efavirenz capsule contents mixed with a small amount of food.

Kaul S, Ji P, Lu M, Nguyen KL, Shangguan T, Grasela D.

Am J Health Syst Pharm. 2010 Feb 1;67(3):217-22. doi: 10.2146/ajhp090327.

PMID: 20101064

 

Discovery of matrix metalloproteases selective and activated peptide-doxorubicin prodrugs as anti-tumor agents.

Hu Z, Jiang X, Albright CF, Graciani N, Yue E, Zhang M, Zhang SY, Bruckner R, Diamond M, Dowling R, Rafalski M, Yeleswaram S, Trainor GL, Seitz SP, Han W.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):853-6. doi: 10.1016/j.bmcl.2009.12.084.

PMID: 20060717

 

Oxime carbamate--discovery of a series of novel FAAH inhibitors.

Sit SY, Conway CM, Xie K, Bertekap R, Bourin C, Burris KD.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. doi: 10.1016/j.bmcl.2009.11.080.

PMID: 20036536

 

Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.

Marcin LR, Mattson RJ, Gao Q, Wu D, Molski TF, Mattson GK, Lodge NJ.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1027-30. doi: 10.1016/j.bmcl.2009.12.043.

PMID: 20034793

 

Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.

Ahmad S, Ngu K, Miller KJ, Wu G, Hung CP, Malmstrom S, Zhang G, O'Tanyi E, Keim WJ, Cullen MJ, Rohrbach KW, Thomas M, Ung T, Qu Q, Gan J, Narayanan R, Pelleymounter MA, Robl JA.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1128-33. doi: 10.1016/j.bmcl.2009.12.014.

PMID: 20022752

 

Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development.

Jin M, Szapiel N, Zhang J, Hickey J, Ghose S.

Biotechnol Bioeng. 2010 Feb 1;105(2):306-16. doi: 10.1002/bit.22532.

PMID: 19739084

 

Development of a zebrafish embryo teratogenicity assay and quantitative prediction model.

Brannen KC, Panzica-Kelly JM, Danberry TL, Augustine-Rauch KA.

Birth Defects Res B Dev Reprod Toxicol. 2010 Feb;89(1):66-77. doi: 10.1002/bdrb.20223.

PMID: 20166227

 

Preformulation designed to enable discovery and assess developability.

Hageman MJ.

Comb Chem High Throughput Screen. 2010 Feb;13(2):90-100. Review.

PMID: 20053164

 

Clinically validated approaches to the treatment of autoimmune diseases.

Carter PH, Zhao Q.

Expert Opin Investig Drugs. 2010 Feb;19(2):195-213. doi: 10.1517/13543780903418452. Review.

PMID: 20050823

 

Spiroindenes and spiroindanes as antagonists of CC chemokine receptor 2: WO 2009023754.

Carter PH.

Expert Opin Ther Pat. 2010 Feb;20(2):283-9. doi: 10.1517/13543770903490437.

PMID: 20100008

 

Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study.

Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, Waterfield W, Schadendorf D, Smylie M, Guthrie T Jr, Grob JJ, Chesney J, Chin K, Chen K, Hoos A, O'Day SJ, Lebbé C.

Lancet Oncol. 2010 Feb;11(2):155-64. doi: 10.1016/S1470-2045(09)70334-1.

PMID: 20004617

 

The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases.

Bhide RS, Lombardo LJ, Hunt JT, Cai ZW, Barrish JC, Galbraith S, Jeyaseelan R Sr, Mortillo S, Wautlet BS, Krishnan B, Kukral D, Malone H, Lewin AC, Henley BJ, Fargnoli J.

Mol Cancer Ther. 2010 Feb;9(2):369-78. doi: 10.1158/1535-7163.MCT-09-0472.

PMID: 20103604

 

Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition.

Fletcher AM, Bregman CL, Woicke J, Salcedo TW, Zidell RH, Janke HE, Fang H, Janusz WJ, Schulze GE, Mense MG.

Toxicol Pathol. 2010 Feb;38(2):267-79. doi: 10.1177/0192623309357950.

PMID: 20100840

 

Mechanism-based inhibition of human cytochrome P4503A4 by domperidone.

Chang SY, Fancher RM, Zhang H, Gan J.

Xenobiotica. 2010 Feb;40(2):138-45. doi: 10.3109/00498250903406762.

PMID: 20082577

 

Pharmacokinetics and safety of twice-daily atazanavir 300 mg and raltegravir 400 mg in healthy individuals.

Zhu L, Butterton J, Persson A, Stonier M, Comisar W, Panebianco D, Breidinger S, Zhang J, Bertz R.

Antivir Ther. 2010;15(8):1107-14. doi: 10.3851/IMP1673.

PMID: 21149917

 

Genotypic determinants and phenotypic properties of antiviral-resistant HBV variants: insight from entecavir resistance studies.

Tenney DJ.

Antivir Ther. 2010;15(3 Pt B):529-35. doi: 10.3851/IMP1504.

PMID: 20516575

 

Infections requiring hospitalization in the abatacept clinical development program: an epidemiological assessment.

Simon TA, Askling J, Lacaille D, Franklin J, Wolfe F, Covucci A, Suissa S, Hochberg MC; Abatacept Epidemiology Study Group..

Arthritis Res Ther. 2010;12(2):R67. doi: 10.1186/ar2984.

PMID: 20398273

 

Systematic LC-MS/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought-out chromatography.

Jemal M, Ouyang Z, Xia YQ.

Biomed Chromatogr. 2010 Jan;24(1):2-19. doi: 10.1002/bmc.1373. Review.

PMID: 20017121

 

Modeling kinetics of a large-scale fed-batch CHO cell culture by Markov chain Monte Carlo method.

Xing Z, Bishop N, Leister K, Li ZJ.

Biotechnol Prog. 2010 Jan-Feb;26(1):208-19. doi: 10.1002/btpr.284.

PMID: 19834967

 

Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.

Kim S, Dinchuk JE, Anthony MN, Orcutt T, Zoeckler ME, Sauer MB, Mosure KW, Vuppugalla R, Grace JE Jr, Simmermacher J, Dulac HA, Pizzano J, Sinz M.

Drug Metab Dispos. 2010 Jan;38(1):16-24. doi: 10.1124/dmd.109.029637.

PMID: 19833845

 

Comparative biotransformation of pyrazinone-containing corticotropin-releasing factor receptor-1 antagonists: minimizing the reactive metabolite formation.

Zhuo X, Hartz RA, Bronson JJ, Wong H, Ahuja VT, Vrudhula VM, Leet JE, Huang S, Macor JE, Shu YZ.

Drug Metab Dispos. 2010 Jan;38(1):5-15. doi: 10.1124/dmd.109.028910.

PMID: 19833844

 

A latent class model for testing for linkage and classifying families when the sample may contain segregating and non-segregating families.

Bastone LA, Spielman RS, Wang X, Ten Have TR, Putt ME.

Hum Hered. 2010;70(2):75-91. doi: 10.1159/000312819.

PMID: 20558995

 

Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.

Pendri A, Troyer TL, Sofia MJ, Walker MA, Naidu BN, Banville J, Meanwell NA, Dicker I, Lin Z, Krystal M, Gerritz SW.

J Comb Chem. 2010 Jan-Feb;12(1):84-90. doi: 10.1021/cc9001026.

PMID: 19902958

 

Adherence and outcomes associated with copayment burden in schizophrenia: a cross-sectional survey.

Kim E, Gupta S, Bolge S, Chen CC, Whitehead R, Bates JA.

J Med Econ. 2010;13(2):185-92. doi: 10.3111/13696991003723023.

PMID: 20235753

 

Non-invasive systemic drug delivery: developability considerations for alternate routes of administration.

Mathias NR, Hussain MA.

J Pharm Sci. 2010 Jan;99(1):1-20. doi: 10.1002/jps.21793. Review.

PMID: 19499570

 

Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits.

Zhang D, He K, Raghavan N, Wang L, Crain EJ, He B, Xin B, Luettgen JM, Wong PC.

J Thromb Thrombolysis. 2010 Jan;29(1):70-80. doi: 10.1007/s11239-009-0401-8.

PMID: 19851712

 

Identification of hepatitis C virus NS5A inhibitors.

Lemm JA, O'Boyle D 2nd, Liu M, Nower PT, Colonno R, Deshpande MS, Snyder LB, Martin SW, St Laurent DR, Serrano-Wu MH, Romine JL, Meanwell NA, Gao M.

J Virol. 2010 Jan;84(1):482-91. doi: 10.1128/JVI.01360-09.

PMID: 19812153

 

Examination of CYP3A and P-glycoprotein-mediated drug-drug interactions using animal models.

Marathe PH, Rodrigues AD.

Methods Mol Biol. 2010;596:385-403. doi: 10.1007/978-1-60761-416-6_17.

PMID: 19949933

 

Synthesis of natural products containing the pyrrolic ring.

Young IS, Thornton PD, Thompson A.

Nat Prod Rep. 2010 Jan;27(12):1801-39. doi: 10.1039/c0np00014k. Review. No abstract available.

PMID: 20936222

 

Correlates of medication adherence among patients with bipolar disorder: results of the bipolar evaluation of satisfaction and tolerability (BEST) study: a nationwide cross-sectional survey.

Bates JA, Whitehead R, Bolge SC, Kim E.

Prim Care Companion J Clin Psychiatry. 2010;12(5). pii: PCC.09m00883. doi: 10.4088/PCC.09m00883yel.

PMID: 21274363

 

Safety assessment considerations and strategies for targeted small molecule cancer therapeutics in drug discovery.

Westhouse RA.

Toxicol Pathol. 2010 Jan;38(1):165-8. doi: 10.1177/0192623309354341. Review.

PMID: 19907054

Back to Top

2009 Publications

Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577.

Shi Y, Li C, O'Connor SP, Zhang J, Shi M, Bisaha SN, Wang Y, Sitkoff D, Pudzianowski AT, Huang C, Klei HE, Kish K, Yanchunas J Jr, Liu EC, Hartl KS, Seiler SM, Steinbacher TE, Schumacher WA, Atwal KS, Stein PD.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9. doi: 10.1016/j.bmcl.2009.10.084.

PMID: 19896847

 

A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist.

Hartz RA, Ahuja VT, Zhuo X, Mattson RJ, Denhart DJ, Deskus JA, Vrudhula VM, Pan S, Ditta JL, Shu YZ, Grace JE, Lentz KA, Lelas S, Li YW, Molski TF, Krishnananthan S, Wong H, Qian-Cutrone J, Schartman R, Denton R, Lodge NJ, Zaczek R, Macor JE, Bronson JJ.

J Med Chem. 2009 Dec 10;52(23):7653-68. doi: 10.1021/jm900716v.

PMID: 19954247

 

Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

Wittman MD, Carboni JM, Yang Z, Lee FY, Antman M, Attar R, Balimane P, Chang C, Chen C, Discenza L, Frennesson D, Gottardis MM, Greer A, Hurlburt W, Johnson W, Langley DR, Li A, Li J, Liu P, Mastalerz H, Mathur A, Menard K, Patel K, Sack J, Sang X, Saulnier M, Smith D, Stefanski K, Trainor G, Velaparthi U, Zhang G, Zimmermann K, Vyas DM.

J Med Chem. 2009 Dec 10;52(23):7360-3. doi: 10.1021/jm900786r.

PMID: 19778024

 

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects.

Wang T, Yin Z, Zhang Z, Bender JA, Yang Z, Johnson G, Yang Z, Zadjura LM, D'Arienzo CJ, DiGiugno Parker D, Gesenberg C, Yamanaka GA, Gong YF, Ho HT, Fang H, Zhou N, McAuliffe BV, Eggers BJ, Fan L, Nowicka-Sans B, Dicker IB, Gao Q, Colonno RJ, Lin PF, Meanwell NA, Kadow JF.

J Med Chem. 2009 Dec 10;52(23):7778-87. doi: 10.1021/jm900843g.

PMID: 19769332

 

Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity.

Mapelli C, Natarajan SI, Meyer JP, Bastos MM, Bernatowicz MS, Lee VG, Pluscec J, Riexinger DJ, Sieber-McMaster ES, Constantine KL, Smith-Monroy CA, Golla R, Ma Z, Longhi DA, Shi D, Xin L, Taylor JR, Koplowitz B, Chi CL, Khanna A, Robinson GW, Seethala R, Antal-Zimanyi IA, Stoffel RH, Han S, Whaley JM, Huang CS, Krupinski J, Ewing WR.

J Med Chem. 2009 Dec 10;52(23):7788-99. doi: 10.1021/jm900752a.

PMID: 19702274

 

Immunoassay-based measurement of clinical biomarkers for monitoring changes in nasal cavity.

Zhang YJ, Luroe S, Schieber F, Kelsey J, Nabbie F, Rizzi G, Richards P, Weiner R, Rhyne PW.

J Pharm Biomed Anal. 2009 Dec 5;50(5):823-30. doi: 10.1016/j.jpba.2009.06.043.

PMID: 19625155

 

Determination of inorganic pharmaceutical counterions using hydrophilic interaction chromatography coupled with a Corona CAD detector.

Huang Z, Richards MA, Zha Y, Francis R, Lozano R, Ruan J.

J Pharm Biomed Anal. 2009 Dec 5;50(5):809-14. doi: 10.1016/j.jpba.2009.06.039.

PMID: 19616396

 

Malignancies in the rheumatoid arthritis abatacept clinical development programme: an epidemiological assessment.

Simon TA, Smitten AL, Franklin J, Askling J, Lacaille D, Wolfe F, Hochberg MC, Qi K, Suissa S.

Ann Rheum Dis. 2009 Dec;68(12):1819-26. doi: 10.1136/ard.2008.097527.

PMID: 19054822

 

Preclinical pharmacokinetics and in vitro metabolism of brivanib (BMS-540215), a potent VEGFR2 inhibitor and its alanine ester prodrug brivanib alaninate.

Marathe PH, Kamath AV, Zhang Y, D'Arienzo C, Bhide R, Fargnoli J.

Cancer Chemother Pharmacol. 2009 Dec;65(1):55-66. doi: 10.1007/s00280-009-1002-0.

PMID: 19396600

 

Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling.

Aranibar N, Bhaskaran V, Ott KH, Vassallo J, Nelson D, Lecureux L, Gong L, Stryker S, Lehman-McKeeman L.

Magn Reson Chem. 2009 Dec;47 Suppl 1:S12-9. doi: 10.1002/mrc.2503.

PMID: 19768707

 

BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.

Carboni JM, Wittman M, Yang Z, Lee F, Greer A, Hurlburt W, Hillerman S, Cao C, Cantor GH, Dell-John J, Chen C, Discenza L, Menard K, Li A, Trainor G, Vyas D, Kramer R, Attar RM, Gottardis MM.

Mol Cancer Ther. 2009 Dec;8(12):3341-9. doi: 10.1158/1535-7163.MCT-09-0499.

PMID: 19996272

 

Position 5.46 of the serotonin 5-HT2A receptor contributes to a species-dependent variation for the 5-HT2C agonist (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: impact on selectivity and toxicological evaluation.

Miller KJ, Wu GY, Varnes JG, Levesque P, Li J, Li D, Robl JA, Rossi KA, Wacker DA.

Mol Pharmacol. 2009 Dec;76(6):1211-9. doi: 10.1124/mol.109.059204.

PMID: 19767451

 

Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder.

Owen R, Sikich L, Marcus RN, Corey-Lisle P, Manos G, McQuade RD, Carson WH, Findling RL.

Pediatrics. 2009 Dec;124(6):1533-40. doi: 10.1542/peds.2008-3782.

PMID: 19948625

 

Nucleophilic capture of the imino-quinone methide type intermediates generated from 2-aminothiazol-5-yl carbinols.

Saulnier MG, Dodier M, Frennesson DB, Langley DR, Vyas DM.

Org Lett. 2009 Nov 19;11(22):5154-7. doi: 10.1021/ol902023g.

PMID: 19827772

 

Strategy of accelerated method development for high-throughput bioanalytical assays using ultra high-performance liquid chromatography coupled with mass spectrometry.

Liu G, Snapp HM, Ji QC, Arnold ME.

Anal Chem. 2009 Nov 15;81(22):9225-32. doi: 10.1021/ac901316w.

PMID: 19856950

 

Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors.

Shi S, Zhu S, Gerritz SW, Rachwal B, Ruan Z, Hutchins R, Kakarla R, Sofia MJ, Sutton J, Cheney D.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6477-80. doi: 10.1016/j.bmcl.2009.08.100.

PMID: 19804972

 

Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

Gavai AV, Fink BE, Fairfax DJ, Martin GS, Rossiter LM, Holst CL, Kim SH, Leavitt KJ, Mastalerz H, Han WC, Norris D, Goyal B, Swaminathan S, Patel B, Mathur A, Vyas DM, Tokarski JS, Yu C, Oppenheimer S, Zhang H, Marathe P, Fargnoli J, Lee FY, Wong TW, Vite GD.

J Med Chem. 2009 Nov 12;52(21):6527-30. doi: 10.1021/jm9010065.

PMID: 19821562

 

Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry.

Tao Y, Li W, Liang W, Van Breemen RB.

J Agric Food Chem. 2009 Nov 11;57(21):10014-21. doi: 10.1021/jf9020224.

PMID: 19817455

 

Inhibition of envelope-mediated CD4+-T-cell depletion by human immunodeficiency virus attachment inhibitors.

Alexander L, Zhang S, McAuliffe B, Connors D, Zhou N, Wang T, Agler M, Kadow J, Lin PF.

Antimicrob Agents Chemother. 2009 Nov;53(11):4726-32. doi: 10.1128/AAC.00494-09.

PMID: 19721067

 

Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents.

Washburn WN.

Expert Opin Ther Pat. 2009 Nov;19(11):1485-99. doi: 10.1517/13543770903337828. Review.

PMID: 19852718

  

A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder.

Marcus RN, Owen R, Kamen L, Manos G, McQuade RD, Carson WH, Aman MG.

J Am Acad Child Adolesc Psychiatry. 2009 Nov;48(11):1110-9. doi: 10.1097/CHI.0b013e3181b76658.

PMID: 19797985

 

Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.

Gillooly KM, Pattoli MA, Taylor TL, Chen L, Cheng L, Gregor KR, Whitney GS, Susulic V, Watterson SH, Kempson J, Pitts WJ, Booth-Lute H, Yang G, Davies P, Kukral DW, Strnad J, McIntyre KW, Darienzo CJ, Salter-Cid L, Yang Z, Wang-Iverson DB, Burke JR.

J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. doi: 10.1124/jpet.109.156018.

PMID: 19652024

 

Comprehensive determination of extractables from five different brands of stoppers used for injectable products.

Corredor CC, Haby TA, Young JD, Shah PA, Varia SA.

PDA J Pharm Sci Technol. 2009 Nov-Dec;63(6):527-36.

PMID: 20169859

 

Increasing high-throughput discovery bioanalysis using automated selected reaction monitoring compound optimization, ultra-high-pressure liquid chromatography, and single-step sample preparation workflows.

Smalley J, Xin B, Olah TV.

Rapid Commun Mass Spectrom. 2009 Nov;23(21):3457-64. doi: 10.1002/rcm.4264.

PMID: 19813283

 

Characterization of S-thiolation on secreted proteins from E. coli by mass spectrometry.

Liu P, Tarnowski MA, O'Mara BW, Wu W, Zhang H, Tamura JK, Ackerman MS, Tao L, Grace MJ, Russell RJ.

Rapid Commun Mass Spectrom. 2009 Oct 30;23(20):3343-9. doi: 10.1002/rcm.4247.

PMID: 19760645

 

Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.

Haque TS, Liang N, Golla R, Seethala R, Ma Z, Ewing WR, Cooper CB, Pelleymounter MA, Poss MA, Cheng D.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5872-6. doi: 10.1016/j.bmcl.2009.08.077.

PMID: 19740659

 

Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.

Zhuo X, Zhao W, Zheng J, Humphreys WG, Shu YZ, Zhu M.

Chem Biol Interact. 2009 Oct 7;181(2):227-35. doi: 10.1016/j.cbi.2009.06.017.

PMID: 19576871

 

Patterns of viral load in chronic hepatitis B patients in Brazil and their association with ALT levels and HBeAg status.

Nita ME, Gaburo N Jr, Cheinquer H, L'Italien G, Affonso de Araujo ES, Mantilla P, Cure-Bolt N, Lotufo PA.

Ann Hepatol. 2009 Oct-Dec;8(4):339-45.

PMID: 20009133

 

Design of a filter train for precipitate removal in monoclonal antibody downstream processing.

Kandula S, Babu S, Jin M, Shukla AA.

Biotechnol Appl Biochem. 2009 Oct 1;54(3):149-55. doi: 10.1042/BA20090181.

PMID: 19656082

 

Population Pharmacokinetic/Pharmacodyanamic Mixture Models via Maximum a Posteriori Estimation.

Wang X, Schumitzky A, D'Argenio DZ.

Comput Stat Data Anal. 2009 Oct 1;53(12):3907-3915.

PMID: 20161085

 

A novel direct homogeneous assay for ATP citrate lyase.

Ma Z, Chu CH, Cheng D.

J Lipid Res. 2009 Oct;50(10):2131-5. doi: 10.1194/jlr.D900008-JLR200.

PMID: 19286649

 

Repeatability of 18F-FDG PET in a multicenter phase I study of patients with advanced gastrointestinal malignancies.

Velasquez LM, Boellaard R, Kollia G, Hayes W, Hoekstra OS, Lammertsma AA, Galbraith SM.

J Nucl Med. 2009 Oct;50(10):1646-54. doi: 10.2967/jnumed.109.063347.

PMID: 19759105

 

Beyond debacle and debate: developing solutions in drug safety.

Ray A.

Nat Rev Drug Discov. 2009 Oct;8(10):775-9. doi: 10.1038/nrd2988.

PMID: 19763107

 

Distinguishing a phosphate ester prodrug from its isobaric sulfate metabolite by mass spectrometry without the metabolite standard.

Wu ST, Cao K, Bonacorsi SJ Jr, Zhang H, Jemal M.

Rapid Commun Mass Spectrom. 2009 Oct;23(19):3107-13. doi: 10.1002/rcm.4228.

PMID: 19714709

 

Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin.

Vassallo JD, Janovitz EB, Wescott DM, Chadwick C, Lowe-Krentz LJ, Lehman-McKeeman LD.

Toxicol Sci. 2009 Oct;111(2):402-12. doi: 10.1093/toxsci/kfp166.

PMID: 19628585

 

Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition.

Kirby M, Yu DM, O'Connor S, Gorrell MD.

Clin Sci (Lond). 2009 Sep 28;118(1):31-41. doi: 10.1042/CS20090047. Review.

PMID: 19780719

 

High-field asymmetric waveform ion mobility spectrometry for determining the location of in-source collision-induced dissociation in electrospray ionization mass spectrometry.

Xia YQ, Jemal M.

Anal Chem. 2009 Sep 15;81(18):7839-43. doi: 10.1021/ac9012336.

PMID: 19691295

 

Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists.

Lloyd J, Finlay HJ, Atwal K, Kover A, Prol J, Yan L, Bhandaru R, Vaccaro W, Huynh T, Huang CS, Conder M, Jenkins-West T, Sun H, Li D, Levesque P.

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5469-73. doi: 10.1016/j.bmcl.2009.07.083.

PMID: 19665893

 

Enrichment and analysis of Alzheimer's Abeta1-42 peptide in human plasma and whole blood.

Ditto NT, Kline TR, Alfinito PD, Slemmon JR.

J Neurosci Methods. 2009 Sep 15;182(2):260-5. doi: 10.1016/j.jneumeth.2009.05.025.

PMID: 19520113

 

Assessing compound binding to the Eg5 motor domain using a thermal shift assay.

McDonnell PA, Yanchunas J, Newitt JA, Tao L, Kiefer SE, Ortega M, Kut S, Burford N, Goldfarb V, Duke GJ, Shen H, Metzler W, Doyle M, Chen Z, Tarby C, Borzilleri R, Vaccaro W, Gottardis M, Lu S, Crews D, Kim K, Lombardo L, Roussell DL.

Anal Biochem. 2009 Sep 1;392(1):59-69. doi: 10.1016/j.ab.2009.05.044.

PMID: 19497292

 

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives.

Wang T, Kadow JF, Zhang Z, Yin Z, Gao Q, Wu D, Parker DD, Yang Z, Zadjura L, Robinson BA, Gong YF, Spicer TP, Blair WS, Shi PY, Yamanaka G, Lin PF, Meanwell NA.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5140-5. doi: 10.1016/j.bmcl.2009.07.076. Erratum in: Bioorg Med Chem Lett. 2010 Feb 15;20(4):1462. Spicer, Timothy P [added].

PMID: 19664921

 

Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies.

Wan H, Huynh T, Pang S, Geng J, Vaccaro W, Poss MA, Trainor GL, Lorenzi MV, Gottardis M, Jayaraman L, Purandare AV.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5063-6. doi: 10.1016/j.bmcl.2009.07.040.

PMID: 19632837

 

Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity.

Meanwell NA, Wallace OB, Wang H, Deshpande M, Pearce BC, Trehan A, Yeung KS, Qiu Z, Wright JJ, Robinson BA, Gong YF, Wang HG, Spicer TP, Blair WS, Shi PY, Lin PF.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5136-9. doi: 10.1016/j.bmcl.2009.07.027. Erratum in: Bioorg Med Chem Lett. 2010 Feb 15;20(4):1461. Spicer, Timothy P [added].

PMID: 19632112

 

What is next for small-molecule drug discovery?

Doweyko AM, Doweyko LM.

Future Med Chem. 2009 Sep;1(6):1029-36. doi: 10.4155/fmc.09.72.

PMID: 21425992

 

Optimal and consistent protein glycosylation in mammalian cell culture.

Hossler P, Khattak SF, Li ZJ.

Glycobiology. 2009 Sep;19(9):936-49. doi: 10.1093/glycob/cwp079. Review.

PMID: 19494347

 

Amorphous drug-PVP dispersions: application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state.

Tobyn M, Brown J, Dennis AB, Fakes M, Gao Q, Gamble J, Khimyak YZ, McGeorge G, Patel C, Sinclair W, Timmins P, Yin S.

J Pharm Sci. 2009 Sep;98(9):3456-68. doi: 10.1002/jps.21738.

PMID: 19603506

 

Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities.

Ji RR, de Silva H, Jin Y, Bruccoleri RE, Cao J, He A, Huang W, Kayne PS, Neuhaus IM, Ott KH, Penhallow B, Cockett MI, Neubauer MG, Siemers NO, Ross-Macdonald P.

PLoS Comput Biol. 2009 Sep;5(9):e1000512. doi: 10.1371/journal.pcbi.1000512.

PMID: 19763178

 

Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds.

Wu Y, Connors D, Barber L, Jayachandra S, Hanumegowda UM, Adams SP.

Toxicol In Vitro. 2009 Sep;23(6):1170-8. doi: 10.1016/j.tiv.2009.06.003.

PMID: 19523510

 

Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.

Sin N, Venables BL, Combrink KD, Gulgeze HB, Yu KL, Civiello RL, Thuring J, Wang XA, Yang Z, Zadjura L, Marino A, Kadow KF, Cianci CW, Clarke J, Genovesi EV, Medina I, Lamb L, Krystal M, Meanwell NA.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4857-62. doi: 10.1016/j.bmcl.2009.06.030.

PMID: 19596574

 

Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer.

Attar RM, Jure-Kunkel M, Balog A, Cvijic ME, Dell-John J, Rizzo CA, Schweizer L, Spires TE, Platero JS, Obermeier M, Shan W, Salvati ME, Foster WR, Dinchuk J, Chen SJ, Vite G, Kramer R, Gottardis MM.

Cancer Res. 2009 Aug 15;69(16):6522-30. doi: 10.1158/0008-5472.CAN-09-1111.

PMID: 19654297

 

Electrochemiluminescence in bioanalysis.

Rhyne PW, Wong OT, Zhang YJ, Weiner RS.

Bioanalysis. 2009 Aug;1(5):919-35. doi: 10.4155/bio.09.80. Review.

PMID: 21083063

 

Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors.

Denhart DJ, Deskus JA, Ditta JL, Gao Q, Dalton King H, Kozlowski ES, Meng Z, LaPaglia MA, Mattson GK, Molski TF, Taber MT, Lodge NJ, Mattson RJ, Macor JE.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4031-3. doi: 10.1016/j.bmcl.2009.06.026.

PMID: 19560923

 

Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors.

Shi Y, Zhang J, Shi M, O'Connor SP, Bisaha SN, Li C, Sitkoff D, Pudzianowski AT, Chong S, Klei HE, Kish K, Yanchunas J Jr, Liu EC, Hartl KS, Seiler SM, Steinbacher TE, Schumacher WA, Atwal KS, Stein PD.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4034-41. doi: 10.1016/j.bmcl.2009.06.014.

PMID: 19541481

 

Further assessment of 17alpha-ethinyl estradiol as an inhibitor of different human cytochrome P450 forms in vitro.

Chang SY, Chen C, Yang Z, Rodrigues AD.

Drug Metab Dispos. 2009 Aug;37(8):1667-75. doi: 10.1124/dmd.109.026997.

PMID: 19454483

 

Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.

Zhang D, He K, Raghavan N, Wang L, Mitroka J, Maxwell BD, Knabb RM, Frost C, Schuster A, Hao F, Gu Z, Humphreys WG, Grossman SJ.

Drug Metab Dispos. 2009 Aug;37(8):1738-48. doi: 10.1124/dmd.108.025981.

PMID: 19420130

  

Degradation pathways of a corticotropin-releasing factor antagonist in solution and solid states.

Badawy S, Hussain M, Zhao F, Ye Q, Huang Y, Palaniswamy V.

J Pharm Sci. 2009 Aug;98(8):2636-47. doi: 10.1002/jps.21637.

PMID: 19072860

 

Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits.

Wong PC, Crain EJ, Watson CA, Xin B.

J Thromb Haemost. 2009 Aug;7(8):1313-20. doi: 10.1111/j.1538-7836.2009.03503.x.

PMID: 19500242

 

A mechanistic study of Protein A chromatography resin lifetime.

Jiang C, Liu J, Rubacha M, Shukla AA.

J Chromatogr A. 2009 Jul 31;1216(31):5849-55. doi: 10.1016/j.chroma.2009.06.013.

PMID: 19539295

 

Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists.

Hartz RA, Ahuja VT, Arvanitis AG, Rafalski M, Yue EW, Denhart DJ, Schmitz WD, Ditta JL, Deskus JA, Brenner AB, Hobbs FW, Payne J, Lelas S, Li YW, Molski TF, Mattson GK, Peng Y, Wong H, Grace JE, Lentz KA, Qian-Cutrone J, Zhuo X, Shu YZ, Lodge NJ, Zaczek R, Combs AP, Olson RE, Bronson JJ, Mattson RJ, Macor JE.

J Med Chem. 2009 Jul 23;52(14):4173-91. doi: 10.1021/jm900301y.

PMID: 19552437

 

In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.

Hartz RA, Ahuja VT, Rafalski M, Schmitz WD, Brenner AB, Denhart DJ, Ditta JL, Deskus JA, Yue EW, Arvanitis AG, Lelas S, Li YW, Molski TF, Wong H, Grace JE, Lentz KA, Li J, Lodge NJ, Zaczek R, Combs AP, Olson RE, Mattson RJ, Bronson JJ, Macor JE.

J Med Chem. 2009 Jul 23;52(14):4161-72. doi: 10.1021/jm900302q. Erratum in: J Med Chem. 2009 Sep 24;52(18):5770.

PMID: 19552436

 

Roller compaction: Application of an in-gap ribbon porosity calculation for the optimization of downstream granule flow and compactability characteristics.

Gamble JF, Tobyn M, Dennis AB, Shah T.

Pharm Dev Technol. 2009 Jul 22. [Epub ahead of print]

PMID: 19624251

 

Current concepts in vascular cognitive impairment and pharmacotherapeutic implications.

Rojas-Fernandez CH, Moorhouse P.

Ann Pharmacother. 2009 Jul;43(7):1310-23. doi: 10.1345/aph.1L703. Review.

PMID: 19584390

 

Ultrasensitive genotypic detection of antiviral resistance in hepatitis B virus clinical isolates.

Fang J, Wichroski MJ, Levine SM, Baldick CJ, Mazzucco CE, Walsh AW, Kienzle BK, Rose RE, Pokornowski KA, Colonno RJ, Tenney DJ.

Antimicrob Agents Chemother. 2009 Jul;53(7):2762-72. doi: 10.1128/AAC.00130-09.

PMID: 19433559

 

 Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Mo R, Meyer DT, Voss ME, Lo YC, Yang G, Miller PB, Scherle PA, Tebben AJ, Carter PH, Decicco CP.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3418-22. doi: 10.1016/j.bmcl.2009.05.041.

PMID: 19481449

 

Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability.

Degnan AP, Conway CM, Dalterio RA, Macci R, Mercer SE, Schartman R, Xu C, Dubowchik GM, Macor JE.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3555-8. doi: 10.1016/j.bmcl.2009.04.150.

PMID: 19467597

 

Scale-up analysis for a CHO cell culture process in large-scale bioreactors.

Xing Z, Kenty BM, Li ZJ, Lee SS.

Biotechnol Bioeng. 2009 Jul 1;103(4):733-46. doi: 10.1002/bit.22287.

PMID: 19280669

 

Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching.

Jian W, Yao M, Zhang D, Zhu M.

Chem Res Toxicol. 2009 Jul;22(7):1246-55. doi: 10.1021/tx900035j.

PMID: 19527004

 

Role of phase II drug metabolizing enzymes in cancer chemoprevention.

Jana S, Mandlekar S.

Curr Drug Metab. 2009 Jul;10(6):595-616. Review.

PMID: 19702535

 

Efficacy and safety of muraglitazar: a double-blind, 24-week, dose-ranging study in patients with type 2 diabetes.

Rubin CJ, Viraswami-Appanna K, Fiedorek FT.

Diab Vasc Dis Res. 2009 Jul;6(3):205-15. doi: 10.1177/1479164109336048.

PMID: 20368213

 

Drug titration patterns and HbA 1c levels in type 2 diabetes.

Maclean JR, Chapman RH, Ferrufino CP, Krishnarajah G.

Int J Clin Pract. 2009 Jul;63(7):1008-16. doi: 10.1111/j.1742-1241.2009.02094.x.

PMID: 19570118

 

Optimal two-stage designs allowing flexibility in number of subjects for phase II clinical trials.

Masaki N, Koyama T, Yoshimura I, Hamada C.

J Biopharm Stat. 2009 Jul;19(4):721-31. doi: 10.1080/10543400902964167.

PMID: 20183436

 

E-novo: an automated workflow for efficient structure-based lead optimization.

Pearce BC, Langley DR, Kang J, Huang H, Kulkarni A.

J Chem Inf Model. 2009 Jul;49(7):1797-809. doi: 10.1021/ci900073k.

PMID: 19552372

 

Abatacept does not induce direct gene expression changes in antigen-presenting cells.

Carman JA, Davis PM, Yang WP, Zhu J, Chang H, He A, Truong A, Suchard SJ, Nadler SG.

J Clin Immunol. 2009 Jul;29(4):479-89. doi: 10.1007/s10875-009-9282-z.

PMID: 19259798

 

Closing the side-chain gap in protein loop modeling.

Rossi KA, Nayeem A, Weigelt CA, Krystek SR Jr.

J Comput Aided Mol Des. 2009 Jul;23(7):411-8. doi: 10.1007/s10822-009-9274-3.

PMID: 19459054

 

Budget impact analysis of ixabepilone used according to FDA approved labeling in treatment-resistant metastatic breast cancer.

Ho J, Zhang L, Todorova L, Whillans F, Corey-Lisle P, Yuan Y.

J Manag Care Pharm. 2009 Jul-Aug;15(6):467-75.

PMID: 19610679

 

Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry.

Zhang H, Zhang D, Ray K, Zhu M.

J Mass Spectrom. 2009 Jul;44(7):999-1016. doi: 10.1002/jms.1610. Review.

PMID: 19598168

 

Phospholipids in liquid chromatography/mass spectrometry bioanalysis: comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects.

Xia YQ, Jemal M.

Rapid Commun Mass Spectrom. 2009 Jul;23(14):2125-38. doi: 10.1002/rcm.4121.

PMID: 19517478

 

Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction.

Zheng M, Wang J, Lubinski J, Flint OP, Krishna R, Yao M, Pursley JM, Thakur A, Boulton DW, Santone KS, Barten DM, Anderson JJ, Felsenstein KM, Hansel SB.

Xenobiotica. 2009 Jul;39(7):544-55. doi: 10.1080/00498250902928555.

PMID: 19480557

 

Quantitative determination of trace levels of hydrogen peroxide in crospovidone and a pharmaceutical product using high performance liquid chromatography with coulometric detection.

Yue H, Bu X, Huang MH, Young J, Raglione T.

Int J Pharm. 2009 Jun 22;375(1-2):33-40. doi: 10.1016/j.ijpharm.2009.03.027.

PMID: 19481688

 

Long-term medical costs and resource utilization in systemic lupus erythematosus and lupus nephritis: a five-year analysis of a large medicaid population.

Li T, Carls GS, Panopalis P, Wang S, Gibson TB, Goetzel RZ.

Arthritis Rheum. 2009 Jun 15;61(6):755-63. doi: 10.1002/art.24545.

PMID: 19479688

 

Application of quantitative LC-MS surrogate peptide methodology in the analysis of the amyloid beta peptide (Abeta) biosynthetic intermediate protein APP-betaCTF.

Cantone JL, Xu-Lin A, Toyn JH, Drexler DM.

J Neurosci Methods. 2009 Jun 15;180(2):255-60. doi: 10.1016/j.jneumeth.2009.03.018.

PMID: 19464516

 

Role of drug substance material properties in the processibility and performance of a wet granulated product.

Vemavarapu C, Surapaneni M, Hussain M, Badawy S.

Int J Pharm. 2009 Jun 5;374(1-2):96-105. doi: 10.1016/j.ijpharm.2009.03.014.

PMID: 19446765

 

Sustained release subcutaneous delivery of BMS-686117, a GLP-1 receptor peptide agonist, via a zinc adduct.

Qian F, Ni N, Burton LS, Wang YF, Desikan S, Hussain M, Smith RL.

Int J Pharm. 2009 Jun 5;374(1-2):46-52. doi: 10.1016/j.ijpharm.2009.03.007.

PMID: 19446758

 

Process research and development for a tetrazole-based growth hormone secretagogue (GHS) pharmaceutical development candidate.

Davulcu AH, McLeod DD, Li J, Katipally K, Littke A, Doubleday W, Xu Z, McConlogue CW, Lai CJ, Gleeson M, Schwinden M, Parsons RL Jr.

J Org Chem. 2009 Jun 5;74(11):4068-79. doi: 10.1021/jo9003508.

PMID: 19391593

 

Use pattern and off-label use of atypical antipsychotics in bipolar disorder, 1998-2002.

Demland JA, Jing Y, Kelton CM, Guo JJ, Li H, Wigle PR.

Am Health Drug Benefits. 2009 Jun;2(4):184-91.

PMID: 25126291

 

Model-based approach to characterize efavirenz autoinduction and concurrent enzyme induction with carbamazepine.

Zhu M, Kaul S, Nandy P, Grasela DM, Pfister M.

Antimicrob Agents Chemother. 2009 Jun;53(6):2346-53. doi: 10.1128/AAC.01120-08.

PMID: 19223624

 

Multiplexing a high-throughput liability assay to leverage efficiencies.

Herbst J, Anthony M, Stewart J, Connors D, Chen T, Banks M, Petrillo EW, Agler M.

Assay Drug Dev Technol. 2009 Jun;7(3):294-303. doi: 10.1089/adt.2008.184.

PMID: 19530896

 

Ion suppression and cannulation locking solutions.

Morgan DG, Olah TV.

Bioanalysis. 2009 Jun;1(3):523-8. doi: 10.4155/bio.09.62.

PMID: 21083149

 

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).

Huynh T, Chen Z, Pang S, Geng J, Bandiera T, Bindi S, Vianello P, Roletto F, Thieffine S, Galvani A, Vaccaro W, Poss MA, Trainor GL, Lorenzi MV, Gottardis M, Jayaraman L, Purandare AV.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2924-7. doi: 10.1016/j.bmcl.2009.04.075.

PMID: 19419866

 

Microbial N-demethylation: biotransformation and recovery of a drug metabolite.

Davis BL, Liu MS, Hanson RL, Parker WL, Patel RN.

Biotechnol Appl Biochem. 2009 Jun;53(Pt 2):133-7. doi: 10.1042/BA20080079.

PMID: 18699775

 

Inflammation, autoimmunity, and atherosclerosis.

Zhao Q.

Discov Med. 2009 Jun;8(40):7-12. Review.

PMID: 19772835

 

Pharmacokinetics of the dipeptidyl peptidase 4 inhibitor saxagliptin in rats, dogs, and monkeys and clinical projections.

Fura A, Khanna A, Vyas V, Koplowitz B, Chang SY, Caporuscio C, Boulton DW, Christopher LJ, Chadwick KD, Hamann LG, Humphreys WG, Kirby M.

Drug Metab Dispos. 2009 Jun;37(6):1164-71. doi: 10.1124/dmd.108.026088.

PMID: 19251818

 

Efficient and effective compound management to support lead optimization.

Johnson CW, Chatterjee M, Kubala S, Helm D, Houston J, Banks M.

J Biomol Screen. 2009 Jun;14(5):523-30. doi: 10.1177/1087057109335747.

PMID: 19483145

 

Best practices in compound management for preserving compound integrity and accurately providing samples for assays.

Matson SL, Chatterjee M, Stock DA, Leet JE, Dumas EA, Ferrante CD, Monahan WE, Cook LS, Watson J, Cloutier NJ, Ferrante MA, Houston JG, Banks MN.

J Biomol Screen. 2009 Jun;14(5):476-84. doi: 10.1177/1087057109336593.

PMID: 19483144

 

Extraction, identification, and functional characterization of a bioactive substance from automated compound-handling plastic tips.

Watson J, Greenough EB, Leet JE, Ford MJ, Drexler DM, Belcastro JV, Herbst JJ, Chatterjee M, Banks M.

J Biomol Screen. 2009 Jun;14(5):566-72. doi: 10.1177/1087057109336594.

PMID: 19470712

 

Phase I study of the effect of gastric acid pH modulators on the bioavailability of oral dasatinib in healthy subjects.

Eley T, Luo FR, Agrawal S, Sanil A, Manning J, Li T, Blackwood-Chirchir A, Bertz R.

J Clin Pharmacol. 2009 Jun;49(6):700-9. doi: 10.1177/0091270009333854.

PMID: 19395585

 

Healthcare costs associated with treatment of bipolar disorder using a mood stabilizer plus adjunctive aripiprazole, quetiapine, risperidone, olanzapine or ziprasidone.

Jing Y, Kim E, You M, Pikalov A, Tran QV.

J Med Econ. 2009 Jun;12(2):104-13. doi: 10.3111/13696990903044092.

PMID: 19527195

 

Rapid screening and characterization of drug metabolites using multiple ion monitoring dependent product ion scan and postacquisition data mining on a hybrid triple quadrupole-linear ion trap mass spectrometer.

Yao M, Ma L, Duchoslav E, Zhu M.

Rapid Commun Mass Spectrom. 2009 Jun;23(11):1683-93. doi: 10.1002/rcm.4045.

PMID: 19418486

 

A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen.

Kieltyka K, Zhang J, Li S, Vath M, Baglieri C, Ferraro C, Zvyaga TA, Drexler DM, Weller HN, Shou WZ.

Rapid Commun Mass Spectrom. 2009 Jun;23(11):1579-91. doi: 10.1002/rcm.4037.

PMID: 19399765

 

Health technology assessment: lessons learned from around the world--an overview.

O'Donnell JC, Pham SV, Pashos CL, Miller DW, Smith MD.

Value Health. 2009 Jun;12 Suppl 2:S1-5. doi: 10.1111/j.1524-4733.2009.00550.x. No abstract available.

PMID: 19523179

 

Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.

Kempson J, Guo J, Das J, Moquin RV, Spergel SH, Watterson SH, Langevine CM, Dyckman AJ, Pattoli M, Burke JR, Yang X, Gillooly KM, McIntyre KW, Chen L, Dodd JH, McKinnon M, Barrish JC, Pitts WJ.

Bioorg Med Chem Lett. 2009 May 15;19(10):2646-9. doi: 10.1016/j.bmcl.2009.03.159.

PMID: 19376699

 

Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE.

Wu YJ, Zhang Y, Good AC, Burton CR, Toyn JH, Albright CF, Macor JE, Thompson LA.

Bioorg Med Chem Lett. 2009 May 15;19(10):2654-60. doi: 10.1016/j.bmcl.2009.03.144.

PMID: 19375914

 

Catalytic asymmetric syntheses of alpha-amino and alpha-hydroxyl acid derivatives.

Han X, Jiang XJ, Civiello RL, Degnan AP, Chaturvedula PV, Macor JE, Dubowchik GM.

J Org Chem. 2009 May 15;74(10):3993-6. doi: 10.1021/jo900368k.

PMID: 19378930

 

A Bayesian approach to joint analysis of longitudinal measurements and competing risks failure time data.

Hu W, Li G, Li N.

Stat Med. 2009 May 15;28(11):1601-19. doi: 10.1002/sim.3562.

PMID: 19308919

 

8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.

Gilligan PJ, He L, Clarke T, Tivitmahaisoon P, Lelas S, Li YW, Heman K, Fitzgerald L, Miller K, Zhang G, Marshall A, Krause C, McElroy J, Ward K, Shen H, Wong H, Grossman S, Nemeth G, Zaczek R, Arneric SP, Hartig P, Robertson DW, Trainor G.

J Med Chem. 2009 May 14;52(9):3073-83. doi: 10.1021/jm9000242.

PMID: 19361210

 

Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists.

Gilligan PJ, Clarke T, He L, Lelas S, Li YW, Heman K, Fitzgerald L, Miller K, Zhang G, Marshall A, Krause C, McElroy JF, Ward K, Zeller K, Wong H, Bai S, Saye J, Grossman S, Zaczek R, Arneric SP, Hartig P, Robertson D, Trainor G.

J Med Chem. 2009 May 14;52(9):3084-92. doi: 10.1021/jm900025h.

PMID: 19361209

 

N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.

Nirschl AA, Zou Y, Krystek SR Jr, Sutton JC, Simpkins LM, Lupisella JA, Kuhns JE, Seethala R, Golla R, Sleph PG, Beehler BC, Grover GJ, Egan D, Fura A, Vyas VP, Li YX, Sack JS, Kish KF, An Y, Bryson JA, Gougoutas JZ, DiMarco J, Zahler R, Ostrowski J, Hamann LG.

J Med Chem. 2009 May 14;52(9):2794-8. doi: 10.1021/jm801583j.

PMID: 19351168

 

Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations.

Zhu M, Zhang D, Zhang H, Shyu WC.

Biopharm Drug Dispos. 2009 May;30(4):163-84. doi: 10.1002/bdd.659.

PMID: 19544287

 

Atherogenesis on the chopping block.

Gargalovic PS.

Cell Metab. 2009 May;9(5):399-401. doi: 10.1016/j.cmet.2009.04.003.

PMID: 19416707

 

Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus.

Komoroski B, Vachharajani N, Feng Y, Li L, Kornhauser D, Pfister M.

Clin Pharmacol Ther. 2009 May;85(5):513-9. doi: 10.1038/clpt.2008.250. Erratum in: Clin Pharmacol Ther. 2009 May;85(5):558.

PMID: 19129749

 

Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects.

Komoroski B, Vachharajani N, Boulton D, Kornhauser D, Geraldes M, Li L, Pfister M.

Clin Pharmacol Ther. 2009 May;85(5):520-6. doi: 10.1038/clpt.2008.251.

PMID: 19129748

 

 Metabolism and excretion of an oral taxane analog, [14C]3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in rats and dogs.

Ly VT, Caceres-Cortes J, Zhang D, Humphreys WG, Ekhato IV, Everett D, Cömezoğlu SN.

Drug Metab Dispos. 2009 May;37(5):1115-28. doi: 10.1124/dmd.108.025809.

PMID: 19196843

 

Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy.

Tenney DJ, Rose RE, Baldick CJ, Pokornowski KA, Eggers BJ, Fang J, Wichroski MJ, Xu D, Yang J, Wilber RB, Colonno RJ.

Hepatology. 2009 May;49(5):1503-14. doi: 10.1002/hep.22841.

PMID: 19280622

 

A sensitive method for the determination of entecavir at picogram per milliliter level in human plasma by solid phase extraction and high-pH LC-MS/MS.

Zhang D, Fu Y, Gale JP, Aubry AF, Arnold ME.

J Pharm Biomed Anal. 2009 May 1;49(4):1027-33. doi: 10.1016/j.jpba.2009.02.003.

PMID: 19285822

 

Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators.

Yang BV, Vaccaro W, Doweyko AM, Doweyko LM, Huynh T, Tortolani D, Nadler SG, McKay L, Somerville J, Holloway DA, Habte S, Weinstein DS, Barrish JC.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2139-43. doi: 10.1016/j.bmcl.2009.03.006.

PMID: 19321341

 

Novel tricyclic inhibitors of IkappaB kinase.

Kempson J, Spergel SH, Guo J, Quesnelle C, Gill P, Belanger D, Dyckman AJ, Li T, Watterson SH, Langevine CM, Das J, Moquin RV, Furch JA, Marinier A, Dodier M, Martel A, Nirschl D, Van Kirk K, Burke JR, Pattoli MA, Gillooly K, McIntyre KW, Chen L, Yang Z, Marathe PH, Wang-Iverson D, Dodd JH, McKinnon M, Barrish JC, Pitts WJ.

J Med Chem. 2009 Apr 9;52(7):1994-2005. doi: 10.1021/jm8015816.

PMID: 19267461

 

Development of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus type 2.

Washburn WN.

J Med Chem. 2009 Apr 9;52(7):1785-94. doi: 10.1021/jm8013019. Review. No abstract available.

PMID: 19243175

 

Algorithm for thorough background subtraction of high-resolution LC/MS data: application to obtain clean product ion spectra from nonselective collision-induced dissociation experiments.

Zhang H, Grubb M, Wu W, Josephs J, Humphreys WG.

Anal Chem. 2009 Apr 1;81(7):2695-700. doi: 10.1021/ac8027189.

PMID: 19254033

 

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.

Guo J, Watson A, Kempson J, Carlsen M, Barbosa J, Stebbins K, Lee D, Dodd J, Nadler SG, McKinnon M, Barrish J, Pitts WJ.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1935-8. doi: 10.1016/j.bmcl.2009.02.060.

PMID: 19272774

 

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns.

Meanwell NA, Wallace OB, Fang H, Wang H, Deshpande M, Wang T, Yin Z, Zhang Z, Pearce BC, James J, Yeung KS, Qiu Z, Kim Wright JJ, Yang Z, Zadjura L, Tweedie DL, Yeola S, Zhao F, Ranadive S, Robinson BA, Gong YF, Wang HG, Spicer TP, Blair WS, Shi PY, Colonno RJ, Lin PF.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1977-81. doi: 10.1016/j.bmcl.2009.02.040. Erratum in: Bioorg Med Chem Lett. 2010 Feb 15;20(4):1460. Spicer, Timothy P [added].

PMID: 19251416

 

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

Gan J, Ruan Q, He B, Zhu M, Shyu WC, Humphreys WG.

Chem Res Toxicol. 2009 Apr;22(4):690-8. doi: 10.1021/tx800368n.

PMID: 19253935

 

Time to psychiatric hospitalization in patients with bipolar disorder treated with a mood stabilizer and adjunctive atypical antipsychotics: a retrospective claims database analysis.

Kim E, Maclean R, Ammerman D, Jing Y, Pikalov A, You M, Van-Tran Q, L'Italien G.

Clin Ther. 2009 Apr;31(4):836-48. doi: 10.1016/j.clinthera.2009.04.022.

PMID: 19446157

 

Aripiprazole augmentation in major depressive disorder: a double-blind, placebo-controlled study in patients with inadequate response to antidepressants.

Berman RM, Fava M, Thase ME, Trivedi MH, Swanink R, McQuade RD, Carson WH, Adson D, Taylor L, Hazel J, Marcus RN.

CNS Spectr. 2009 Apr;14(4):197-206.

PMID: 19407731

 

Coadministration of muraglitazar plus glyburide: improvement of glycaemic and lipid profiles in patients with type 2 diabetes.

Rubin CJ, De Pril V, Fiedorek FT.

Diab Vasc Dis Res. 2009 Apr;6(2):120-32. doi: 10.1177/1479164109336049.

PMID: 20368202

 

Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes.

List JF, Woo V, Morales E, Tang W, Fiedorek FT.

Diabetes Care. 2009 Apr;32(4):650-7. doi: 10.2337/dc08-1863.

PMID: 19114612

 

 CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183).

Zhang D, Ly VT, Lago M, Tian Y, Gan J, Humphreys WG, Cömezoglu SN.

Drug Metab Dispos. 2009 Apr;37(4):710-8. doi: 10.1124/dmd.108.024398.

PMID: 19158314

 

Sulfation of o-demethyl apixaban: enzyme identification and species comparison.

Wang L, Raghavan N, He K, Luettgen JM, Humphreys WG, Knabb RM, Pinto DJ, Zhang D.

Drug Metab Dispos. 2009 Apr;37(4):802-8. doi: 10.1124/dmd.108.025593.

PMID: 19131519

 

Engineering enzymes for improved catalytic efficiency: a computational study of site mutagenesis in epothilone-B hydroxylase.

Nayeem A, Chiang SJ, Liu SW, Sun Y, You L, Basch J.

Protein Eng Des Sel. 2009 Apr;22(4):257-66. doi: 10.1093/protein/gzn081.

PMID: 19179341

 

Strain-related differences in urine composition of male rats of potential relevance to urolithiasis.

Tannehill-Gregg SH, Dominick MA, Reisinger AJ, Moehlenkamp JD, Waites CR, Stock DA, Sanderson TP, Cohen SM, Arnold LL, Schilling BE.

Toxicol Pathol. 2009 Apr;37(3):293-305. doi: 10.1177/0192623309332990.

PMID: 19380840

 

Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism.

Lecureux L, Dieter MZ, Nelson DM, Watson L, Wong H, Gemzik B, Klaassen CD, Lehman-McKeeman LD.

Toxicol Sci. 2009 Apr;108(2):482-91. doi: 10.1093/toxsci/kfp026.

PMID: 19211616

 

Enhancement of oral bioavailability of an HIV-attachment inhibitor by nanosizing and amorphous formulation approaches.

Fakes MG, Vakkalagadda BJ, Qian F, Desikan S, Gandhi RB, Lai C, Hsieh A, Franchini MK, Toale H, Brown J.

Int J Pharm. 2009 Mar 31;370(1-2):167-74. doi: 10.1016/j.ijpharm.2008.11.018.

PMID: 19100319

 

Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation.

Latek R, Fleener C, Lamian V, Kulbokas E 3rd, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R.

Transplantation. 2009 Mar 27;87(6):926-33. doi: 10.1097/TP.0b013e31819b5a58.

PMID: 19300198

 

A new approach to the determination of column overload characteristics in reversed-phase liquid chromatography.

Dai J, Carr PW, McCalley DV.

J Chromatogr A. 2009 Mar 20;1216(12):2474-82. doi: 10.1016/j.chroma.2009.01.036.

PMID: 19187938

 

Synthesis of 3-substituted-4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with amines.

Xiao Z, Yang MG, Li P, Carter PH.

Org Lett. 2009 Mar 19;11(6):1421-4. doi: 10.1021/ol802946p.

PMID: 19243133

 

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

Schroeder GM, An Y, Cai ZW, Chen XT, Clark C, Cornelius LA, Dai J, Gullo-Brown J, Gupta A, Henley B, Hunt JT, Jeyaseelan R, Kamath A, Kim K, Lippy J, Lombardo LJ, Manne V, Oppenheimer S, Sack JS, Schmidt RJ, Shen G, Stefanski K, Tokarski JS, Trainor GL, Wautlet BS, Wei D, Williams DK, Zhang Y, Zhang Y, Fargnoli J, Borzilleri RM.

J Med Chem. 2009 Mar 12;52(5):1251-4. doi: 10.1021/jm801586s.

PMID: 19260711

 

Enhancing the reagent selection workflow via real-time vendor inventory.

Nirschl DS, Hermsmeier MA, Silber G, Logan JV, Hammar R, Young DL.

J Comb Chem. 2009 Mar 9;11(2):206-9. doi: 10.1021/cc8001603. No abstract available.

PMID: 19053504

 

Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

Zhang H, Ryono DE, Devasthale P, Wang W, O'Malley K, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Locke K, Zhang L, Lippy J, Kunselman L, Morgan N, Flynn N, Moore L, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Doweyko AM, Bell A, Chang C, Muckelbauer J, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1451-6. doi: 10.1016/j.bmcl.2009.01.030.

PMID: 19201606

 

A non-randomized study to investigate the effects of the atypical antipsychotic aripiprazole on the steady-state pharmacokinetics of lamotrigine in patients with bipolar I disorder.

Schieber FC, Boulton DW, Balch AH, Croop R, Mallikaarjun S, Benson J, Carlson BX.

Hum Psychopharmacol. 2009 Mar;24(2):145-52. doi: 10.1002/hup.999.

PMID: 19132712

 

Basic science for the clinician 49: expanding the description of the RNA universe.

Sigal LH.

J Clin Rheumatol. 2009 Mar;15(2):90-4. doi: 10.1097/RHU.0b013e31819c3a49.

PMID: 19265356

 

Comprehensive two-dimensional liquid chromatography separations of pharmaceutical samples using dual Fused-Core columns in the 2nd dimension.

Alexander AJ, Ma L.

J Chromatogr A. 2009 Feb 27;1216(9):1338-45. doi: 10.1016/j.chroma.2008.12.063.

PMID: 19150719

 

Discovery and structure-activity relationships of trisubstituted pyrimidines/pyridines as novel calcium-sensing receptor antagonists.

Yang W, Ruan Z, Wang Y, Van Kirk K, Ma Z, Arey BJ, Cooper CB, Seethala R, Feyen JH, Dickson JK Jr.

J Med Chem. 2009 Feb 26;52(4):1204-8. doi: 10.1021/jm801178c.

PMID: 19143533

 

Normalization strategies for metabonomic analysis of urine samples.

Warrack BM, Hnatyshyn S, Ott KH, Reily MD, Sanders M, Zhang H, Drexler DM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):547-52. doi: 10.1016/j.jchromb.2009.01.007.

PMID: 19185549

 

A preparatively convenient ligand-free catalytic PEG 2000 Suzuki-Miyaura coupling.

Razler TM, Hsiao Y, Qian F, Fu R, Khan RK, Doubleday W.

J Org Chem. 2009 Feb 6;74(3):1381-4. doi: 10.1021/jo802277z.

PMID: 19178357

 

Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Brogan JB, Mo R, Lo YC, Yang G, Miller PB, Scherle PA, Molino BF, Carter PH, Decicco CP.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):597-601. doi: 10.1016/j.bmcl.2008.12.062.

PMID: 19131247

 

New approaches for inhibiting HIV integrase: a journey beyond the active site.

Walker MA.

Curr Opin Investig Drugs. 2009 Feb;10(2):129-36. Review.

PMID: 19197790

 

Factors associated with the discontinuation of evidence-based cardiovascular therapies in patients with stable coronary artery disease: a primary care perspective.

Mostaza JM, Lahoz C, Martín-Jadraque R, Sanmartín MA, Vicente I, Tranche S, Taboada M, Mantilla T, Monteiro B, Sanchez-Zamorano MA; PRESENAP study..

Eur J Cardiovasc Prev Rehabil. 2009 Feb;16(1):34-8. doi: 10.1097/HJR.0b013e32831a47f3.

PMID: 19237995

 

Rat nasal lavage biomarkers to assess preclinical irritation potential of nasal drug formulations and excipients.

Mathias NR, Moench P, Heran C, Hussain MA, Smith RL.

J Pharm Sci. 2009 Feb;98(2):495-502. doi: 10.1002/jps.21449.

PMID: 18506818

 

Discovery of ixabepilone.

Hunt JT.

Mol Cancer Ther. 2009 Feb;8(2):275-81. doi: 10.1158/1535-7163.MCT-08-0999. Review.

PMID: 19174552

 

Drug essentials. The cytochrome P450 microenzyme system and targeted therapies: Minimizing drug interactions.

Wilkes GM.

Oncology (Williston Park). 2009 Feb;23(2 Suppl Nurse Ed):33, 52-6. No abstract available.

PMID: 19856586

 

Validation of a simple activity participation measure for rheumatoid arthritis clinical trials.

Li T, Wells G, Westhovens R, Tugwell P.

Rheumatology (Oxford). 2009 Feb;48(2):170-5. doi: 10.1093/rheumatology/ken448.

PMID: 19141573

 

Pulmonary delivery of a GLP-1 receptor agonist, BMS-686117.

Qian F, Mathias N, Moench P, Chi C, Desikan S, Hussain M, Smith RL.

Int J Pharm. 2009 Jan 21;366(1-2):218-20. doi: 10.1016/j.ijpharm.2008.10.020.

PMID: 19027057

 

Highly efficacious factor Xa inhibitors containing alpha-substituted phenylcycloalkyl P4 moieties.

Qiao JX, King SR, He K, Wong PC, Rendina AR, Luettgen JM, Xin B, Knabb RM, Wexler RR, Lam PY.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):462-8. doi: 10.1016/j.bmcl.2008.11.049.

PMID: 19046881

 

 On the thermodynamics of cocrystal formation.

Schartman RR.

Int J Pharm. 2009 Jan 5;365(1-2):77-80. doi: 10.1016/j.ijpharm.2008.08.029.

PMID: 18804155

 

Drug interactions with potential rubber closure extractables. Identification of thiol-disulfide exchange reaction products of captopril and thiurams.

Corredor C, Tomasella FP, Young J.

J Chromatogr A. 2009 Jan 2;1216(1):43-8. doi: 10.1016/j.chroma.2008.11.021.

PMID: 19041978

 

Mechanistic insight into the palladium-catalyzed 1,4-oxidation of 1,3-dienes to 1,4-dicarboxy-alk-2-enes.

Eastgate MD, Buono FG.

Angew Chem Int Ed Engl. 2009;48(32):5958-61. doi: 10.1002/anie.200901614. No abstract available.

PMID: 19569150

 

Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer.

Dhar TG, Yang G, Davies P, Malley MF, Gougoutas JZ, Wu DR, Barrish JC, Carter PH.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):96-9. doi: 10.1016/j.bmcl.2008.11.002.

PMID: 19010676

 

Preclinical efficacy spectrum and pharmacokinetics of ixabepilone.

Lee FY, Smykla R, Johnston K, Menard K, McGlinchey K, Peterson RW, Wiebesiek A, Vite G, Fairchild CR, Kramer R.

Cancer Chemother Pharmacol. 2009 Jan;63(2):201-12. doi: 10.1007/s00280-008-0727-5.

PMID: 18350296

 

The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors.

Huang F, Greer A, Hurlburt W, Han X, Hafezi R, Wittenberg GM, Reeves K, Chen J, Robinson D, Li A, Lee FY, Gottardis MM, Clark E, Helman L, Attar RM, Dongre A, Carboni JM.

Cancer Res. 2009 Jan 1;69(1):161-70. doi: 10.1158/0008-5472.CAN-08-0835.

PMID: 19117999

 

Antiarrhythmic drug therapy for atrial fibrillation: focus on atrial selectivity and safety.

Li D, Sun H, Levesque P.

Cardiovasc Hematol Agents Med Chem. 2009 Jan;7(1):64-75. Review.

PMID: 19149545

 

The p38alpha kinase plays a central role in inflammation.

Schieven GL.

Curr Top Med Chem. 2009;9(11):1038-48. Review.

PMID: 19747121

 

Apixaban metabolism and pharmacokinetics after oral administration to humans.

Raghavan N, Frost CE, Yu Z, He K, Zhang H, Humphreys WG, Pinto D, Chen S, Bonacorsi S, Wong PC, Zhang D.

Drug Metab Dispos. 2009 Jan;37(1):74-81. doi: 10.1124/dmd.108.023143.

PMID: 18832478

 

Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS).

Cömezoğlu SN, Ly VT, Zhang D, Humphreys WG, Bonacorsi SJ, Everett DW, Cohen MB, Gan J, Beumer JH, Beijnen JH, Schellens HM, Lappin G.

Drug Metab Pharmacokinet. 2009;24(6):511-22.

PMID: 20045986

 

Assessment of 18F-labeled mitochondrial complex I inhibitors as PET myocardial perfusion imaging agents in rats, rabbits, and primates.

Yu M, Guaraldi M, Kagan M, Mistry M, McDonald J, Bozek J, Yalamanchili P, Hayes M, Azure M, Purohit A, Radeke H, Casebier DS, Robinson SP.

Eur J Nucl Med Mol Imaging. 2009 Jan;36(1):63-72. doi: 10.1007/s00259-008-0909-8.

PMID: 18716773

 

Efficacy and tolerability of ready-to-use intravenous paracetamol solution as monotherapy or as an adjunct analgesic therapy for postoperative pain in patients undergoing elective ambulatory surgery: open, prospective study.

Göröcs TS, Lambert M, Rinne T, Krekler M, Modell S.

Int J Clin Pract. 2009 Jan;63(1):112-20. doi: 10.1111/j.1742-1241.2008.01914.x.

PMID: 19125998

 

Multivariate dose response test.

Tsai KT, Peace KE.

J Biopharm Stat. 2009;19(2):273-9. doi: 10.1080/10543400802622428.

PMID: 19212879

 

Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.

Roberge JY, Harikrishnan LS, Kamau MG, Ruan Z, Van Kirk K, Liu Y, Cooper CB, Poss MA, Dickson JK Jr, Gavai AV, Chao ST, Leith LW, Bednarz MS, Mathur A, Kakarla R, Schnur DM, Vaz R, Lawrence RM.

J Comb Chem. 2009 Jan-Feb;11(1):72-82. doi: 10.1021/cc800051u.

PMID: 19086798

 

Chapter 12. The use of receptor homology modeling to facilitate the design of selective chemokine receptor antagonists.

Carter PH, Tebben AJ.

Methods Enzymol. 2009;461:249-79. doi: 10.1016/S0076-6879(09)05412-3.

PMID: 19480923

 

Gene set enrichment analysis.

Tilford CA, Siemers NO.

Methods Mol Biol. 2009;563:99-121. doi: 10.1007/978-1-60761-175-2_6.

PMID: 19597782

 

Ethyl methanesulphonate in a parenteral formulation of BMS-214662 mesylate, a selective farnesyltransferase inhibitor: formation and rate of hydrolysis.

Nassar MN, Cucolo M, Miller SA.

Pharm Dev Technol. 2009;14(6):672-7. doi: 10.3109/10837450902980262.

PMID: 19883257

 

Understanding drug-excipient compatibility: oxidation of compound A in a solid dosage form.

Wu Y, Dali M, Gupta A, Raghavan K.

Pharm Dev Technol. 2009;14(5):556-64. doi: 10.1080/10837450903182140.

PMID: 19743950

 

Experimental and model-based approaches to studying mixing in coating pans.

Fichana D, Marchut AJ, Ohlsson PH, Chang SY, Lyngberg O, Dougherty J, Kiang S, Stamato H, Chaudhuri B, Muzzio F.

Pharm Dev Technol. 2009;14(2):173-84. doi: 10.1080/10837450802498886.

PMID: 19519189

 

Monitoring and end-point prediction of a small scale wet granulation process using acoustic emission.

Gamble JF, Dennis AB, Tobyn M.

Pharm Dev Technol. 2009;14(3):299-304. doi: 10.1080/10837450802603618.

PMID: 19519182

 

Estimation of drug solubility in polymers via differential scanning calorimetry and utilization of the fox equation.

Haddadin R, Qian F, Desikan S, Hussain M, Smith RL.

Pharm Dev Technol. 2009;14(1):18-26. doi: 10.1080/10837450802409370.

PMID: 18825543

 

Effect of unpurified Cremophor EL on the solution stability of paclitaxel.

Gogate US, Schwartz PA, Agharkar SN.

Pharm Dev Technol. 2009;14(1):1-8. doi: 10.1080/10837450802409354.

PMID: 18791935

 

Sheehan Suicidality Tracking Scale (Sheehan-STS): Preliminary Results from a Multicenter Clinical Trial in Generalized Anxiety Disorder.

Coric V, Stock EG, Pultz J, Marcus R, Sheehan DV.

Psychiatry (Edgmont). 2009 Jan;6(1):26-31.

PMID: 19724740

 

Atypical antipsychotic drugs and diabetes mellitus in the US Food and Drug Administration Adverse Event database: a systematic Bayesian signal detection analysis.

Baker RA, Pikalov A, Tran QV, Kremenets T, Arani RB, Doraiswamy PM.

Psychopharmacol Bull. 2009;42(1):11-31.

PMID: 19204649

 

Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability.

Wong PC, Crain EJ, Watson CA, Hua J, Schumacher WA, Rehfuss R.

Thromb Haemost. 2009 Jan;101(1):108-15.

PMID: 19132196

 

The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: cellular mechanisms and clinical implications.

Flint OP, Noor MA, Hruz PW, Hylemon PB, Yarasheski K, Kotler DP, Parker RA, Bellamine A.

Toxicol Pathol. 2009 Jan;37(1):65-77. doi: 10.1177/0192623308327119. Review.

PMID: 19171928

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