The tumor microenvironment contains multiple immune pathways which can be manipulated by a tumor to evade immune response. In most cases, tumors use more than one immune suppression mechanism, or develop new mechanisms over the course of the disease, which means we will need a variety of different approaches to address a patient’s specific tumor biology.

At Bristol Myers Squibb, we are investigating how potentially complementary signaling pathways interact and, through our research, are exploring ways to leverage the complex tumor microenvironment to reset and optimize anti-tumor immunity.

Explore the articles below to learn more about the science behind the tumor microenvironment and the immune system. Also read about the potential of combinations in cancer therapy and the need for partnering with collaborators in order to advance the science as quickly as possible.